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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RSU1 Gene

protein-coding   GIFtS: 61
GCID: GC10M016672

Ras Suppressor Protein 1

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ras Suppressor Protein 11 2     Ras Suppressor Protein 1 Variant 32
RSP-12 3     rsu-12
Ras Suppressor Protein 1 Variant 12     RSP13
Ras Suppressor Protein 1 Variant 22     Rsu-13

External Ids:    HGNC: 104641   Entrez Gene: 62512   Ensembl: ENSG000001484847   OMIM: 1795555   UniProtKB: Q154043   

Export aliases for RSU1 gene to outside databases

Previous GC identifers: GC10M016617 GC10M016785 GC10M016638 GC10M016637


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RSU1 Gene:
This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and
nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In
mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple
alternatively spliced transcript variants for this gene have been reported; one of these variants was found only
in glioma tumors. (provided by RefSeq, Jul 2008)

GeneCards Summary for RSU1 Gene: 
RSU1 (Ras suppressor protein 1) is a protein-coding gene. Diseases associated with RSU1 include glioblastoma, and alzheimer's disease, and among its related super-pathways are Cell-cell junction organization and Cell-extracellular matrix interactions. An important paralog of this gene is LRRC8E.

UniProtKB/Swiss-Prot: RSU1_HUMAN, Q15404
Function: Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras
transformation in vitro

Gene Wiki entry for RSU1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008705.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RSU1 gene promoter:
         AP-1   ATF-2   NRSF form 1   c-Jun   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRSU1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RSU1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RSU1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p13   Ensembl cytogenetic band:  10p13   HGNC cytogenetic band: 10p13

RSU1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RSU1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M016672:  view genomic region     (about GC identifiers)

Start:
16,632,610 bp from pter      End:
16,859,527 bp from pter
Size:
226,918 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RSU1_HUMAN, Q15404 (See protein sequence)
Recommended Name: Ras suppressor protein 1  
Size: 277 amino acids; 31540 Da
Secondary accessions: A8KA46 D3DRU3 Q6FI17
Alternative splicing: 2 isoforms:  Q15404-1   Q15404-2   

Explore the universe of human proteins at neXtProt for RSU1: NX_Q15404

Explore proteomics data for RSU1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15404

  • RSU1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RSU1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_036557.1  NP_689937.2  

    ENSEMBL proteins: 
     ENSP00000367154   ENSP00000339521   ENSP00000473588  
    Reactome Protein details: Q15404
    Human Recombinant Protein Products for RSU1: 
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    Novus Biologicals RSU1 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RSU1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    RSU1 for ontologies           About GeneDecksing



    RSU1 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for RSU1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR025875 Leu-rich_rpt_4
     IPR003591 Leu-rich_rpt_typical-subtyp

    Graphical View of Domain Structure for InterPro Entry Q15404

    ProtoNet protein and cluster: Q15404

    1 Blocks protein domain: IPB001611 Leucine-rich repeat signature

    UniProtKB/Swiss-Prot: RSU1_HUMAN, Q15404
    Similarity: Contains 7 LRR (leucine-rich) repeats


    RSU1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RSU1_HUMAN, Q15404
    Function: Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras
    transformation in vitro

         Genatlas biochemistry entry for RSU1:
    suppressor of transformation by activated RAS,ubiquitous (see TSG10C)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    RSU1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RSU1:
     Decreased focal adhesion (FA)   Synthetic lethal with c-Myc af  Weaker migration 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RSU1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RSU1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RSU1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RSU1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RSU1
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate RSU1 (see all 34):
    hsa-miR-579 hsa-miR-513a-5p hsa-miR-4272 hsa-miR-500a hsa-miR-409-5p hsa-miR-3688-3p hsa-miR-27a hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidRSU1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSU1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RSU1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell-cell junction organization
    Cell junction organization0.69
    Cell-Cell communication0.64
    2Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
    Regulation of cytoskeletal remodeling and cell spreading by IPP complex components0.44
    Cell-extracellular matrix interactions0.44
    3Rho Family GTPases
    ILK Signaling0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RSU1
        ILK Signaling

    4        Reactome Pathways for RSU1
        Cell-extracellular matrix interactions
    Cell junction organization
    Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
    Cell-Cell communication



    RSU1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RSU1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for RSU1 (Q154042, 3 ENSP000003395214) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSK3BP498412, 3MINT-8257669 I2D: score=2 
    LIMS1P480593, ENSP000003317754I2D: score=2 STRING: ENSP00000331775
    ACP6Q9NPH03, ENSP000003582414I2D: score=1 STRING: ENSP00000358241
    ILKQ134183, ENSP000002994214I2D: score=2 STRING: ENSP00000299421
    RAF1P040493, ENSP000002518494I2D: score=2 STRING: ENSP00000251849
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS1508180
    GO:0007265Ras protein signal transduction IEA--
    GO:0034329cell junction assembly TAS--

    RSU1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RSU1

    Search CenterWatch for drugs/clinical trials and news about RSU1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RSU1 gene (2 alternative transcripts): 
    NM_012425.3  NM_152724.2  

    Unigene Cluster for RSU1:

    Ras suppressor protein 1
    Hs.524161  [show with all ESTs]
    Unigene Representative Sequence: NM_012425
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377921(uc001iok.3) ENST00000345264(uc001iol.3 uc001iom.3 uc001ion.3)
    ENST00000464074 ENST00000377911 ENST00000602389

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RSU1
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate RSU1 (see all 34):
    hsa-miR-579 hsa-miR-513a-5p hsa-miR-4272 hsa-miR-500a hsa-miR-409-5p hsa-miR-3688-3p hsa-miR-27a hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidRSU1 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RSU1
    Clone
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    OriGene clones in human, mouse for RSU1 (see all 12)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RSU1 (NM_152724)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RSU1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSU1
    Sirion Biotech Customized lentivirus for stable overexpression of RSU1 
                         Customized lentivirus expression plasmids for stable overexpression of RSU1 
    Primer
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    OriGene qPCR primer pairs and template standards for RSU1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RSU1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RSU1

    Additional mRNA sequence: 

    AK055596.1 AK225681.1 AK292911.1 AK312520.1 BC005993.1 BC008691.1 BC015644.2 BC016337.1 
    BC065296.1 BC107898.1 BX647733.1 CR536521.1 CR541840.1 

    17 DOTS entries:

    DT.418428  DT.100838611  DT.100838606  DT.100838605  DT.100838600  DT.100814528  DT.100838608  DT.100838610 
    DT.121230634  DT.92451439  DT.101986287  DT.91691663  DT.95079775  DT.100838602  DT.121230610  DT.92451451 
    DT.40132951 

    24/347 AceView cDNA sequences (see all 347):

    CA306161 AI336042 BP340589 AI138627 CA443004 AI269779 BM663144 AA234672 
    BQ722642 AW769201 AI678491 R73814 AI671683 CA441440 T28285 BQ427581 
    AI141366 N27245 AA332805 H81790 BC005993 CD366555 BX444538 BE780540 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RSU1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                    -                                   -     -               
    SP2:              -     -                                   -     -               
    SP3:                    -                                   -     -               
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for RSU1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RSU1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTTTCAA
    RSU1 Expression
    About this image


    See RSU1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RSU1

    SOURCE GeneReport for Unigene cluster: Hs.524161
        SABiosciences Custom PCR Arrays for RSU1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSU1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RSU1 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rsu11 , 5 Ras suppressor protein 11, 5 88.57(n)1
    97.11(a)1
      2 (9.73 cM)5
    201631  NM_009105.31  NP_033131.21 
     130769675 
    chicken
    (Gallus gallus)
    Aves RSU11 Ras suppressor protein 1 85.68(n)
    96.03(a)
      420524  NM_001199591.1  NP_001186520.1 
    lizard
    (Anolis carolinensis)
    Reptilia RSU16
    Uncharacterized protein
    95(a)
    1 ↔ 1
    6(18523587-18614183)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.87122 Xenopus laevis transcribed sequence with strong similarity more 80.88(n)    CF271017.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rsu11 Ras suppressor protein 1 77.14(n)
    90.97(a)
      553276  XM_002666676.1  XP_002666722.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BG:BACR48E02.43
    ics1
    small GTPase regulatory/interacting
    protein3
    icarus1
    58(a)3
    58.27(n)1
    59.77(a)1
      34C63
    347741  NM_135821.41  NP_609665.21 
    worm
    (Caenorhabditis elegans)
    Secernentea C34C12.53
    rsu-11
    RSP1 protein3
    Protein RSU-11
    60(a)3
    58.69(n)1
    59.07(a)1
      III(3543823-3545382)3
    1754511  NM_065315.51  NP_497716.11 


    ENSEMBL Gene Tree for RSU1 (if available)
    TreeFam Gene Tree for RSU1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RSU1 gene
    LRRC8E2  LRCH22  LRRC182  LRSAM12  LRRC8A2  ENSG000002719492  PIDD2  LRCH32  
    LRRC8D2  LRRC282  LRRC572  LRRC8B2  LRRC8C2  LRCH42  LRCH12  
    9 SIMAP similar genes for RSU1 using alignment to 3 protein entries:     RSU1_HUMAN (see all proteins):
    LRRC8C    LRRC8B    LRRC1    LRRC40    LRCH2    ERBB2IP
    FLII    SCRIB    LRRD1

    RSU1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for RSU1
    PGOHUM00000238444 PGOHUM00000261964 PGOHUM00000238799


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5826 SNPs in RSU1 are shown (see all 5826)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1385919151,2
    --16632120(+) AAAGGC/TCACCT 2 -- ds50010--------
    rs1163799031,2
    C,F--16632182(+) GAGGCG/AGGCAG 2 -- ds50012Minor allele frequency- A:0.07WA EA 238
    rs1440557701,2
    C--16632212(+) GAGTTA/CGAGAC 2 -- ds50010--------
    rs1473005751,2
    --16632291(+) GTGCCA/GGAATC 2 -- ds50010--------
    rs79166921,2
    C,F,A--16632329(+) GAATCG/ACTTGA 2 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs101284881,2
    C--16632358(+) GCAGTA/GGGCTG 2 -- ds50014Minor allele frequency- G:0.15WA NA EA 360
    rs1498021881,2
    C--16632370(+) GATCAC/TGCTAT 2 -- ds50010--------
    rs1872359351,2
    --16632443(+) AACTTC/TGGATA 2 -- ds50010--------
    rs79166131,2
    C,F,H--16632520(+) TAACAA/CAAAGA 2 -- ds50018Minor allele frequency- C:0.09NS NA CSA WA 914
    rs1920249311,2
    --16632533(+) AAAAAC/GCCTCC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for RSU1 (16632610 - 16859527 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for RSU1 (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2733595CNV Deletion23290073
    esv2671383CNV Deletion23128226
    esv2171921CNV Deletion18987734
    esv2661909CNV Deletion23128226
    esv2446889CNV Deletion19546169
    esv275522CNV Loss21479260
    nsv24610CNV Loss16902084
    nsv831799CNV Loss17160897
    nsv831797CNV Loss17160897
    nsv466758CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 179555    OMIM disorders: --

    2 diseases for RSU1:    About MalaCards
    glioblastoma    alzheimer's disease


    RSU1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for RSU1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma 53.7 5 7624154 (2), 12510772 (2)
    tumors 0 4 12510772 (2), 7624154 (1)

    Genetic Association Database (GAD): RSU1
    Human Genome Epidemiology (HuGE) Navigator: RSU1 (2 documents)

    Export disorders for RSU1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RSU1 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with RSU1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human RSU1 is highly homologous to mouse Rsu-1 and localizes to human chromosome 10. (PubMed id 8288261)1, 2, 3 Tsuda T. and Cutler M.L. (1993)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    4. Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. (PubMed id 15242332)1, 2 Aboulaich N.... Vener A.V. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    8. Identification of an alternatively spliced RNA for the Ras suppressor RSU-1 in human gliomas. (PubMed id 12510772)1, 9 Chunduru S....Cutler M.L. (2002)
    9. The Ras suppressor RSU-1 localizes to 10p13 and its expression in the U251 glioblastoma cell line correlates with a decrease in growth rate and tumorigenic potential. (PubMed id 7624154)1, 9 Tsuda T....Cutler M.L. (1995)
    10. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6251 HGNC: 10464 AceView: RSU1 Ensembl:ENSG00000148484 euGenes: HUgn6251
    ECgene: RSU1 H-InvDB: RSU1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RSU1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RSU1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RSU1 gene:
    Search GeneIP for patents involving RSU1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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