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Aliases for RSU1 Gene

Aliases for RSU1 Gene

  • Ras Suppressor Protein 1 2 3 5
  • Rsu-1 3 4
  • RSP-1 3 4
  • Ras Suppressor Protein 1 Variant 1 3
  • Ras Suppressor Protein 1 Variant 2 3
  • Ras Suppressor Protein 1 Variant 3 3
  • Ras Suppressor Protein 1 Variant 5 3
  • RSP1 4

External Ids for RSU1 Gene

Previous GeneCards Identifiers for RSU1 Gene

  • GC10M016617
  • GC10M016785
  • GC10M016638
  • GC10M016637

Summaries for RSU1 Gene

Entrez Gene Summary for RSU1 Gene

  • This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008]

GeneCards Summary for RSU1 Gene

RSU1 (Ras Suppressor Protein 1) is a Protein Coding gene. Among its related pathways are Cell junction organization and ERK Signaling. An important paralog of this gene is LRRD1.

UniProtKB/Swiss-Prot for RSU1 Gene

  • Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.

Gene Wiki entry for RSU1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSU1 Gene

Genomics for RSU1 Gene

Regulatory Elements for RSU1 Gene

Enhancers for RSU1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G016816 1.1 ENCODE 39.7 +0.1 69 2.7 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZBTB7B YY1 SP3 ZHX2 RSU1 MINDY3 ENSG00000275001
GH10G016827 1 Ensembl ENCODE 31.5 -11.2 -11169 2.2 TBP CTCF ATF1 ZSCAN4 FEZF1 ZNF2 RAD21 ZNF121 EGR1 SCRT2 RSU1 GC10M016823 GC10P016843
GH10G016831 0.8 Ensembl ENCODE 35.9 -15.4 -15370 1.8 POLR2A JUN ZMYM3 MNT FOS RSU1 GC10M016823 GC10P016843
GH10G016809 0.6 ENCODE 27.5 +8.0 8042 0.1 CTCF ZNF654 TRIM22 REST RAD21 ZNF579 ZNF512 SMC3 ZNF143 NBN RSU1 ENSG00000275001
GH10G016786 1 FANTOM5 ENCODE 12.6 +29.7 29656 2.0 MTA2 BHLHE40 NR2F1 TBX21 MEF2D EGR1 POLR2A RELB NFE2 FOS RSU1 TRDMT1 ENSG00000275001
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RSU1 on UCSC Golden Path with GeneCards custom track

Promoters for RSU1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000025022 128 2001 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZBTB7B YY1 SP3 ZHX2 NFYC

Genomic Location for RSU1 Gene

Chromosome:
10
Start:
16,590,611 bp from pter
End:
16,817,528 bp from pter
Size:
226,918 bases
Orientation:
Minus strand

Genomic View for RSU1 Gene

Genes around RSU1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RSU1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RSU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSU1 Gene

Proteins for RSU1 Gene

  • Protein details for RSU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15404-RSU1_HUMAN
    Recommended name:
    Ras suppressor protein 1
    Protein Accession:
    Q15404
    Secondary Accessions:
    • A8KA46
    • D3DRU3
    • Q6FI17

    Protein attributes for RSU1 Gene

    Size:
    277 amino acids
    Molecular mass:
    31540 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RSU1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RSU1 Gene

Post-translational modifications for RSU1 Gene

  • Ubiquitination at Lys158
  • Modification sites at PhosphoSitePlus

Other Protein References for RSU1 Gene

No data available for DME Specific Peptides for RSU1 Gene

Domains & Families for RSU1 Gene

Protein Domains for RSU1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RSU1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for RSU1 Gene

Function for RSU1 Gene

Molecular function for RSU1 Gene

GENATLAS Biochemistry:
suppressor of transformation by activated RAS,ubiquitous (see TSG10C)
UniProtKB/Swiss-Prot Function:
Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.

Gene Ontology (GO) - Molecular Function for RSU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20926685
genes like me logo Genes that share ontologies with RSU1: view
genes like me logo Genes that share phenotypes with RSU1: view

Animal Model Products

CRISPR Products

miRNA for RSU1 Gene

miRTarBase miRNAs that target RSU1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RSU1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RSU1 Gene

Localization for RSU1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RSU1 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RSU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA 20926685
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with RSU1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RSU1 Gene

Pathways & Interactions for RSU1 Gene

genes like me logo Genes that share pathways with RSU1: view

Gene Ontology (GO) - Biological Process for RSU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 1508180
GO:0010810 NOT regulation of cell-substrate adhesion IMP 20926685
GO:0010811 positive regulation of cell-substrate adhesion IMP 20926685
GO:0043547 positive regulation of GTPase activity IMP 20926685
genes like me logo Genes that share ontologies with RSU1: view

No data available for SIGNOR curated interactions for RSU1 Gene

Drugs & Compounds for RSU1 Gene

No Compound Related Data Available

Transcripts for RSU1 Gene

mRNA/cDNA for RSU1 Gene

(3) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RSU1 Gene

Ras suppressor protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RSU1

Alternative Splicing Database (ASD) splice patterns (SP) for RSU1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: - - - -
SP3: - - -
SP4:
SP5:

Relevant External Links for RSU1 Gene

GeneLoc Exon Structure for
RSU1
ECgene alternative splicing isoforms for
RSU1

Expression for RSU1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RSU1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RSU1 Gene

This gene is overexpressed in Platelet (11.5) and Seminal vesicle (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RSU1 Gene



Protein tissue co-expression partners for RSU1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RSU1 Gene:

RSU1

SOURCE GeneReport for Unigene cluster for RSU1 Gene:

Hs.524161

Evidence on tissue expression from TISSUES for RSU1 Gene

  • Nervous system(4.8)
  • Blood(4.3)
  • Skin(4.3)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with RSU1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RSU1 Gene

Orthologs for RSU1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RSU1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RSU1 34 35
  • 99.4 (n)
oppossum
(Monodelphis domestica)
Mammalia RSU1 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RSU1 34 35
  • 92.42 (n)
cow
(Bos Taurus)
Mammalia RSU1 34 35
  • 91.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RSU1 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rsu1 34
  • 89.41 (n)
mouse
(Mus musculus)
Mammalia Rsu1 34 16 35
  • 88.57 (n)
chicken
(Gallus gallus)
Aves RSU1 34 35
  • 85.68 (n)
lizard
(Anolis carolinensis)
Reptilia RSU1 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rsu1 34
  • 81.35 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8712 34
zebrafish
(Danio rerio)
Actinopterygii rsu1 34 35
  • 77.14 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008785 34
  • 60.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta ics 34 35
  • 58.27 (n)
BG:BACR48E02.4 36
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea C34C12.5 36
  • 60 (a)
rsu-1 34 35
  • 59.47 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 69 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4919 34
Species where no ortholog for RSU1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RSU1 Gene

ENSEMBL:
Gene Tree for RSU1 (if available)
TreeFam:
Gene Tree for RSU1 (if available)

Paralogs for RSU1 Gene

(9) SIMAP similar genes for RSU1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for RSU1 Gene

genes like me logo Genes that share paralogs with RSU1: view

Variants for RSU1 Gene

Sequence variations from dbSNP and Humsavar for RSU1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000028311 -- 16,661,236(+) TGTTT(G/T)GTAAT intron-variant
rs1000033446 -- 16,788,174(+) TCAGC(C/T)TCATG intron-variant
rs1000039935 -- 16,662,988(+) AAAAA(A/C)ACCCT intron-variant
rs1000053800 -- 16,784,866(+) CAAGA(C/T)GAGAT intron-variant
rs1000060898 -- 16,783,304(+) CTCGA(C/T)GTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RSU1 Gene

Variant ID Type Subtype PubMed ID
esv2171921 CNV deletion 18987734
esv2446889 CNV deletion 19546169
esv2661909 CNV deletion 23128226
esv2671383 CNV deletion 23128226
esv2733595 CNV deletion 23290073
esv275522 CNV loss 21479260
esv2759735 CNV loss 17122850
esv3578656 CNV loss 25503493
esv3578657 CNV loss 25503493
esv3578658 CNV loss 25503493
esv3622474 CNV loss 21293372
esv3622477 CNV gain 21293372
esv3891765 CNV gain 25118596
nsv1046088 CNV gain 25217958
nsv1069457 CNV deletion 25765185
nsv24610 CNV deletion 16902084
nsv466758 CNV gain 19166990
nsv470923 CNV gain 18288195
nsv550020 CNV gain 21841781
nsv831797 CNV loss 17160897
nsv831798 CNV gain+loss 17160897
nsv831799 CNV loss 17160897
nsv831800 CNV gain 17160897
nsv947750 CNV duplication 23825009
nsv947751 CNV duplication 23825009

Variation tolerance for RSU1 Gene

Residual Variation Intolerance Score: 44.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RSU1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RSU1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSU1 Gene

Disorders for RSU1 Gene

Relevant External Links for RSU1

Genetic Association Database (GAD)
RSU1
Human Genome Epidemiology (HuGE) Navigator
RSU1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RSU1

No disorders were found for RSU1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RSU1 Gene

Publications for RSU1 Gene

  1. Human RSU1 is highly homologous to mouse Rsu-1 and localizes to human chromosome 10. (PMID: 8288261) Tsuda T. … Cutler M.L. (Genomics 1993) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. (PMID: 15242332) Aboulaich N. … Vener A.V. (Biochem. J. 2004) 3 4 64

Products for RSU1 Gene

Sources for RSU1 Gene

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