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Aliases for RSU1 Gene

Aliases for RSU1 Gene

  • Ras Suppressor Protein 1 2 3
  • Rsu-1 3 4
  • RSP-1 3 4
  • Ras Suppressor Protein 1 Variant 1 3
  • Ras Suppressor Protein 1 Variant 2 3
  • Ras Suppressor Protein 1 Variant 3 3
  • RSP1 4

External Ids for RSU1 Gene

Previous GeneCards Identifiers for RSU1 Gene

  • GC10M016617
  • GC10M016785
  • GC10M016638
  • GC10M016637

Summaries for RSU1 Gene

Entrez Gene Summary for RSU1 Gene

  • This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008]

GeneCards Summary for RSU1 Gene

RSU1 (Ras Suppressor Protein 1) is a Protein Coding gene. Among its related pathways are ERK Signaling and Cell junction organization. An important paralog of this gene is MFHAS1.

UniProtKB/Swiss-Prot for RSU1 Gene

  • Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro

Gene Wiki entry for RSU1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSU1 Gene

Genomics for RSU1 Gene

Regulatory Elements for RSU1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RSU1 Gene

Start:
16,590,611 bp from pter
End:
16,817,528 bp from pter
Size:
226,918 bases
Orientation:
Minus strand

Genomic View for RSU1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RSU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSU1 Gene

Proteins for RSU1 Gene

  • Protein details for RSU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15404-RSU1_HUMAN
    Recommended name:
    Ras suppressor protein 1
    Protein Accession:
    Q15404
    Secondary Accessions:
    • A8KA46
    • D3DRU3
    • Q6FI17

    Protein attributes for RSU1 Gene

    Size:
    277 amino acids
    Molecular mass:
    31540 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RSU1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RSU1 Gene

Proteomics data for RSU1 Gene at MOPED

Post-translational modifications for RSU1 Gene

  • Ubiquitination at Lys158
  • Modification sites at PhosphoSitePlus

Other Protein References for RSU1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RSU1 Gene

Domains for RSU1 Gene

Protein Domains for RSU1 Gene

Graphical View of Domain Structure for InterPro Entry

Q15404

UniProtKB/Swiss-Prot:

RSU1_HUMAN :
  • Q15404
Similarity:
  • Contains 7 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with RSU1: view

No data available for Gene Families for RSU1 Gene

Function for RSU1 Gene

Molecular function for RSU1 Gene

GENATLAS Biochemistry: suppressor of transformation by activated RAS,ubiquitous (see TSG10C)
UniProtKB/Swiss-Prot Function: Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro

Gene Ontology (GO) - Molecular Function for RSU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20926685
genes like me logo Genes that share ontologies with RSU1: view

Phenotypes for RSU1 Gene

genes like me logo Genes that share phenotypes with RSU1: view

Animal Model Products

CRISPR Products

miRNA for RSU1 Gene

miRTarBase miRNAs that target RSU1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RSU1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RSU1 Gene

Localization for RSU1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RSU1 Gene COMPARTMENTS Subcellular localization image for RSU1 gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for RSU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA 20926685
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with RSU1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RSU1 Gene

Pathways for RSU1 Gene

genes like me logo Genes that share pathways with RSU1: view

Gene Ontology (GO) - Biological Process for RSU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 1508180
GO:0007265 Ras protein signal transduction IEA --
GO:0010810 NOT regulation of cell-substrate adhesion IMP 20926685
GO:0010811 positive regulation of cell-substrate adhesion IMP 20926685
GO:0034329 cell junction assembly TAS --
genes like me logo Genes that share ontologies with RSU1: view

Transcripts for RSU1 Gene

Unigene Clusters for RSU1 Gene

Ras suppressor protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RSU1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RSU1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: - - - -
SP3: - - -
SP4:
SP5:

Relevant External Links for RSU1 Gene

GeneLoc Exon Structure for
RSU1
ECgene alternative splicing isoforms for
RSU1

Expression for RSU1 Gene

mRNA expression in normal human tissues for RSU1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RSU1 Gene

SOURCE GeneReport for Unigene cluster for RSU1 Gene Hs.524161

genes like me logo Genes that share expressions with RSU1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RSU1 Gene

Orthologs for RSU1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RSU1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RSU1 35
  • 99.4 (n)
  • 99.28 (a)
RSU1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RSU1 35
  • 91.22 (n)
  • 98.19 (a)
RSU1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RSU1 35
  • 92.42 (n)
  • 98.19 (a)
RSU1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rsu1 35
  • 88.57 (n)
  • 97.11 (a)
Rsu1 16
Rsu1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RSU1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RSU1 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rsu1 35
  • 89.41 (n)
  • 97.11 (a)
chicken
(Gallus gallus)
Aves RSU1 35
  • 85.68 (n)
  • 96.03 (a)
RSU1 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RSU1 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8712 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rsu1 35
  • 81.35 (n)
  • 93.86 (a)
zebrafish
(Danio rerio)
Actinopterygii rsu1 35
  • 77.14 (n)
  • 90.97 (a)
rsu1 36
  • 91 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008785 35
  • 60.28 (n)
  • 60.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta ics 35
  • 58.27 (n)
  • 59.77 (a)
ics 36
  • 57 (a)
OneToOne
BG:BACR48E02.4 37
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea rsu-1 35
  • 59.47 (n)
  • 61.2 (a)
rsu-1 36
  • 57 (a)
OneToOne
C34C12.5 37
  • 60 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4919 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToOne
Species with no ortholog for RSU1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RSU1 Gene

ENSEMBL:
Gene Tree for RSU1 (if available)
TreeFam:
Gene Tree for RSU1 (if available)

Paralogs for RSU1 Gene

Selected SIMAP similar genes for RSU1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for RSU1 Gene

genes like me logo Genes that share paralogs with RSU1: view

Variants for RSU1 Gene

Sequence variations from dbSNP and Humsavar for RSU1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs6977 -- 16,593,101(-) ATAGA(C/T)ATCAC utr-variant-3-prime
rs10445 -- 16,752,624(-) ATCTC(A/G)CTGCC synonymous-codon, reference
rs780616 -- 16,772,400(+) GAAAT(C/T)TTGCA intron-variant
rs780617 -- 16,772,664(-) ttttc(C/T)tgttt intron-variant
rs780622 -- 16,760,248(+) ctcat(G/T)cctgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RSU1 Gene

Variant ID Type Subtype PubMed ID
nsv894907 CNV Gain 21882294
nsv831797 CNV Loss 17160897
nsv831798 CNV Gain+Loss 17160897
nsv831799 CNV Loss 17160897
nsv894908 CNV Gain 21882294
esv2446889 CNV Deletion 19546169
esv2171921 CNV Deletion 18987734
esv2661909 CNV Deletion 23128226
nsv24610 CNV Loss 16902084
esv2671383 CNV Deletion 23128226
dgv225e1 CNV Complex 17122850
nsv466758 CNV Gain 19166990
nsv470923 CNV Gain 18288195
esv2733595 CNV Deletion 23290073
nsv831800 CNV Gain 17160897
nsv894909 CNV Gain 21882294
esv275522 CNV Loss 21479260

Relevant External Links for RSU1 Gene

HapMap Linkage Disequilibrium report
RSU1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSU1 Gene

Disorders for RSU1 Gene

(2) Novoseek inferred disease relationships for RSU1 Gene

Disease -log(P) Hits PubMed IDs
glioblastoma 53.7 4
tumors 0 3

Relevant External Links for RSU1

Genetic Association Database (GAD)
RSU1
Human Genome Epidemiology (HuGE) Navigator
RSU1
genes like me logo Genes that share disorders with RSU1: view

No data available for UniProtKB/Swiss-Prot for RSU1 Gene

Publications for RSU1 Gene

  1. Human RSU1 is highly homologous to mouse Rsu-1 and localizes to human chromosome 10. (PMID: 8288261) Tsuda T. … Cutler M.L. (Genomics 1993) 2 3 4
  2. The Ras suppressor RSU-1 localizes to 10p13 and its expression in the U251 glioblastoma cell line correlates with a decrease in growth rate and tumorigenic potential. (PMID: 7624154) Tsuda T. … Cutler M.L. (Oncogene 1995) 3 23
  3. Identification of an alternatively spliced RNA for the Ras suppressor RSU-1 in human gliomas. (PMID: 12510772) Chunduru S. … Cutler M.L. (J. Neurooncol. 2002) 3 23
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for RSU1 Gene

Sources for RSU1 Gene

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