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Aliases for RSU1 Gene

Aliases for RSU1 Gene

  • Ras Suppressor Protein 1 2 3 5
  • Rsu-1 3 4
  • RSP-1 3 4
  • Ras Suppressor Protein 1 Variant 1 3
  • Ras Suppressor Protein 1 Variant 2 3
  • Ras Suppressor Protein 1 Variant 3 3
  • Ras Suppressor Protein 1 Variant 5 3
  • RSP1 4

External Ids for RSU1 Gene

Previous GeneCards Identifiers for RSU1 Gene

  • GC10M016617
  • GC10M016785
  • GC10M016638
  • GC10M016637

Summaries for RSU1 Gene

Entrez Gene Summary for RSU1 Gene

  • This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008]

GeneCards Summary for RSU1 Gene

RSU1 (Ras Suppressor Protein 1) is a Protein Coding gene. Among its related pathways are ERK Signaling and Cell junction organization. An important paralog of this gene is LRRC30.

UniProtKB/Swiss-Prot for RSU1 Gene

  • Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.

Gene Wiki entry for RSU1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSU1 Gene

Genomics for RSU1 Gene

Regulatory Elements for RSU1 Gene

Promoters for RSU1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RSU1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RSU1 Gene

Chromosome:
10
Start:
16,590,611 bp from pter
End:
16,817,528 bp from pter
Size:
226,918 bases
Orientation:
Minus strand

Genomic View for RSU1 Gene

Genes around RSU1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RSU1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RSU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSU1 Gene

Proteins for RSU1 Gene

  • Protein details for RSU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15404-RSU1_HUMAN
    Recommended name:
    Ras suppressor protein 1
    Protein Accession:
    Q15404
    Secondary Accessions:
    • A8KA46
    • D3DRU3
    • Q6FI17

    Protein attributes for RSU1 Gene

    Size:
    277 amino acids
    Molecular mass:
    31540 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RSU1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RSU1 Gene

Proteomics data for RSU1 Gene at MOPED

Post-translational modifications for RSU1 Gene

  • Ubiquitination at Lys 158
  • Modification sites at PhosphoSitePlus

Other Protein References for RSU1 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for RSU1

No data available for DME Specific Peptides for RSU1 Gene

Domains & Families for RSU1 Gene

Protein Domains for RSU1 Gene

Graphical View of Domain Structure for InterPro Entry

Q15404

UniProtKB/Swiss-Prot:

RSU1_HUMAN :
  • Contains 7 LRR (leucine-rich) repeats.
Similarity:
  • Contains 7 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with RSU1: view

No data available for Gene Families for RSU1 Gene

Function for RSU1 Gene

Molecular function for RSU1 Gene

GENATLAS Biochemistry:
suppressor of transformation by activated RAS,ubiquitous (see TSG10C)
UniProtKB/Swiss-Prot Function:
Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.
genes like me logo Genes that share phenotypes with RSU1: view

Animal Model Products

miRNA for RSU1 Gene

miRTarBase miRNAs that target RSU1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RSU1 Gene

Localization for RSU1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RSU1 Gene COMPARTMENTS Subcellular localization image for RSU1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 2
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RSU1 Gene

Pathways & Interactions for RSU1 Gene

genes like me logo Genes that share pathways with RSU1: view

Gene Ontology (GO) - Biological Process for RSU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010810 NOT regulation of cell-substrate adhesion IMP 20926685
GO:0010811 positive regulation of cell-substrate adhesion IMP 20926685
genes like me logo Genes that share ontologies with RSU1: view

No data available for SIGNOR curated interactions for RSU1 Gene

Drugs & Compounds for RSU1 Gene

No Compound Related Data Available

Transcripts for RSU1 Gene

Unigene Clusters for RSU1 Gene

Ras suppressor protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RSU1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: - - - -
SP3: - - -
SP4:
SP5:

Relevant External Links for RSU1 Gene

GeneLoc Exon Structure for
RSU1
ECgene alternative splicing isoforms for
RSU1

Expression for RSU1 Gene

mRNA expression in normal human tissues for RSU1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RSU1 Gene

This gene is overexpressed in Platelet (11.5) and Seminal vesicle (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RSU1 Gene



SOURCE GeneReport for Unigene cluster for RSU1 Gene Hs.524161

genes like me logo Genes that share expression patterns with RSU1: view

Protein tissue co-expression partners for RSU1 Gene

- Elite partner

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RSU1 Gene

Orthologs for RSU1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RSU1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RSU1 35
  • 91.22 (n)
  • 98.19 (a)
RSU1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RSU1 35
  • 92.42 (n)
  • 98.19 (a)
RSU1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rsu1 35
  • 88.57 (n)
  • 97.11 (a)
Rsu1 16
Rsu1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RSU1 35
  • 99.4 (n)
  • 99.28 (a)
RSU1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rsu1 35
  • 89.41 (n)
  • 97.11 (a)
oppossum
(Monodelphis domestica)
Mammalia RSU1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RSU1 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves RSU1 35
  • 85.68 (n)
  • 96.03 (a)
RSU1 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RSU1 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rsu1 35
  • 81.35 (n)
  • 93.86 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8712 35
zebrafish
(Danio rerio)
Actinopterygii rsu1 35
  • 77.14 (n)
  • 90.97 (a)
rsu1 36
  • 91 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BG:BACR48E02.4 37
  • 58 (a)
ics 35
  • 58.27 (n)
  • 59.77 (a)
ics 36
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008785 35
  • 60.28 (n)
  • 60.53 (a)
worm
(Caenorhabditis elegans)
Secernentea C34C12.5 37
  • 60 (a)
rsu-1 35
  • 59.47 (n)
  • 61.2 (a)
rsu-1 36
  • 57 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4919 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToOne
Species with no ortholog for RSU1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RSU1 Gene

ENSEMBL:
Gene Tree for RSU1 (if available)
TreeFam:
Gene Tree for RSU1 (if available)

Paralogs for RSU1 Gene

(9) SIMAP similar genes for RSU1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for RSU1 Gene

genes like me logo Genes that share paralogs with RSU1: view

Variants for RSU1 Gene

Sequence variations from dbSNP and Humsavar for RSU1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs6977 -- 16,593,101(-) ATAGA(C/T)ATCAC utr-variant-3-prime
rs10445 -- 16,752,624(-) ATCTC(A/G)CTGCC reference, synonymous-codon
rs812426 -- 16,815,134(+) GCAGG(C/G)GCAGC intron-variant
rs813601 -- 16,806,709(+) TTACA(C/T)AGGCA intron-variant
rs780616 -- 16,772,400(+) GAAAT(C/T)TTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RSU1 Gene

Variant ID Type Subtype PubMed ID
nsv894907 CNV Gain 21882294
nsv831797 CNV Loss 17160897
nsv831798 CNV Gain+Loss 17160897
nsv831799 CNV Loss 17160897
nsv894908 CNV Gain 21882294
esv2446889 CNV Deletion 19546169
esv2171921 CNV Deletion 18987734
esv2661909 CNV Deletion 23128226
nsv24610 CNV Loss 16902084
esv2671383 CNV Deletion 23128226
dgv225e1 CNV Complex 17122850
nsv466758 CNV Gain 19166990
nsv470923 CNV Gain 18288195
esv2733595 CNV Deletion 23290073
nsv831800 CNV Gain 17160897
nsv894909 CNV Gain 21882294
esv275522 CNV Loss 21479260

Variation tolerance for RSU1 Gene

Residual Variation Intolerance Score: 44.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RSU1 Gene

HapMap Linkage Disequilibrium report
RSU1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSU1 Gene

Disorders for RSU1 Gene

Relevant External Links for RSU1

Genetic Association Database (GAD)
RSU1
Human Genome Epidemiology (HuGE) Navigator
RSU1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RSU1

No disorders were found for RSU1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RSU1 Gene

Publications for RSU1 Gene

  1. Human RSU1 is highly homologous to mouse Rsu-1 and localizes to human chromosome 10. (PMID: 8288261) Tsuda T. … Cutler M.L. (Genomics 1993) 2 3 4 67
  2. Identification of an alternatively spliced RNA for the Ras suppressor RSU-1 in human gliomas. (PMID: 12510772) Chunduru S. … Cutler M.L. (J. Neurooncol. 2002) 3 23
  3. The Ras suppressor RSU-1 localizes to 10p13 and its expression in the U251 glioblastoma cell line correlates with a decrease in growth rate and tumorigenic potential. (PMID: 7624154) Tsuda T. … Cutler M.L. (Oncogene 1995) 3 23
  4. Ras suppressor-1 promotes apoptosis in breast cancer cells by inhibiting PINCH-1 and activating p53-upregulated-modulator of apoptosis (PUMA); verification from metastatic breast cancer human samples. (PMID: 25647720) Giotopoulou N. … Gkretsi V. (Clin. Exp. Metastasis 2015) 3
  5. Elimination of Ras Suppressor-1 from hepatocellular carcinoma cells hinders their in vitro metastatic properties. (PMID: 25750304) Gkretsi V. … Bogdanos D.P. (Anticancer Res. 2015) 3

Products for RSU1 Gene

Sources for RSU1 Gene

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