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Aliases for RSRP1 Gene

Aliases for RSRP1 Gene

  • Arginine And Serine Rich Protein 1 2 3 5
  • Arginine/Serine-Rich Protein 1 2 3
  • C1orf63 3 4
  • Chromosome 1 Open Reading Frame 63 2
  • UPF0471 Protein C1orf63 3
  • NPD014 3

External Ids for RSRP1 Gene

Previous HGNC Symbols for RSRP1 Gene

  • C1orf63

Previous GeneCards Identifiers for RSRP1 Gene

  • GC01M025569

Summaries for RSRP1 Gene

GeneCards Summary for RSRP1 Gene

RSRP1 (Arginine And Serine Rich Protein 1) is a Protein Coding gene.

Additional gene information for RSRP1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSRP1 Gene

Genomics for RSRP1 Gene

Regulatory Elements for RSRP1 Gene

Enhancers for RSRP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H025231 1.7 FANTOM5 ENCODE dbSUPER 13.6 +105.5 105493 2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 FOS RSRP1 SYF2 RUNX3 ENSG00000284602 ENSG00000284657
GH01H025903 1.4 ENCODE dbSUPER 10.5 -567.4 -567404 4 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS GPN2 MTFR1L ENSG00000261349 ENSG00000207302 ENSG00000261025 ENSG00000231953 RPL39P7 PIGV LOC101928324 ENSG00000236528
GH01H026069 1.3 ENCODE dbSUPER 10.5 -732.2 -732241 1 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 CBX5 GATA2 ELK1 FOS TRIM63 GPN2 ARID1A LOC101928324 HMGN2 LOC101928728 GPATCH3 ENSG00000261349 RSRP1 GC01P026102
GH01H026077 1.2 ENCODE dbSUPER 10.5 -741.1 -741061 2 HDGF PKNOX1 ATF1 TCF12 ZNF766 GATA2 ATF7 CAVIN1 NCOA1 REST TRIM63 SLC30A2 PDIK1L ENSG00000252190 ENSG00000252691 GPN2 ZNF593 ENSG00000236782 FAM110D RSRP1
GH01H025020 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6.5 +315.5 315521 4 HDGF PKNOX1 ZFP64 SIN3A YBX1 GLIS2 ZNF143 ZNF207 ATF7 FOS RUNX3 LOC105376878 RSRP1 SYF2 SRRM1 MIR4425 GC01M024955
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RSRP1 on UCSC Golden Path with GeneCards custom track

Promoters for RSRP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003349 113 3801 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 SP3 REST

Genomic Location for RSRP1 Gene

Chromosome:
1
Start:
25,242,237 bp from pter
End:
25,338,213 bp from pter
Size:
95,977 bases
Orientation:
Minus strand

Genomic View for RSRP1 Gene

Genes around RSRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RSRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RSRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSRP1 Gene

Proteins for RSRP1 Gene

  • Protein details for RSRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUV0-RSRP1_HUMAN
    Recommended name:
    Arginine/serine-rich protein 1
    Protein Accession:
    Q9BUV0
    Secondary Accessions:
    • A8K917
    • Q49AA4
    • Q5TH71
    • Q9GZP6

    Protein attributes for RSRP1 Gene

    Size:
    290 amino acids
    Molecular mass:
    33613 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RSRP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RSRP1 Gene

Post-translational modifications for RSRP1 Gene

  • Ubiquitination at isoforms=2, 3188
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RSRP1 Gene

Domains & Families for RSRP1 Gene

Gene Families for RSRP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RSRP1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for RSRP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BUV0

UniProtKB/Swiss-Prot:

RSRP1_HUMAN :
  • Belongs to the RSRP family.
Family:
  • Belongs to the RSRP family.
genes like me logo Genes that share domains with RSRP1: view

Function for RSRP1 Gene

Phenotypes From GWAS Catalog for RSRP1 Gene

Gene Ontology (GO) - Molecular Function for RSRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with RSRP1: view
genes like me logo Genes that share phenotypes with RSRP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RSRP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RSRP1 Gene

Localization for RSRP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RSRP1 gene
Compartment Confidence
nucleus 3
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RSRP1 Gene

Pathways & Interactions for RSRP1 Gene

SuperPathways for RSRP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RSRP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RSRP1 Gene

Drugs & Compounds for RSRP1 Gene

No Compound Related Data Available

Transcripts for RSRP1 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RSRP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RSRP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - - - - - - - -
SP2: - - -
SP3:
SP4: - - -
SP5:
SP6: - - - - - - - - - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - -
SP10: -
SP11:

Relevant External Links for RSRP1 Gene

GeneLoc Exon Structure for
RSRP1
ECgene alternative splicing isoforms for
RSRP1

Expression for RSRP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RSRP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RSRP1 Gene:

RSRP1

Evidence on tissue expression from TISSUES for RSRP1 Gene

  • Nervous system(4.7)
  • Lung(3.7)
  • Intestine(2.4)
genes like me logo Genes that share expression patterns with RSRP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RSRP1 Gene

Orthologs for RSRP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RSRP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1ORF63 34
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia D4Wsu53e 34
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C1orf63 34
  • 74 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1orf63 34
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C1orf63 34
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 52 (a)
OneToMany
-- 34
  • 38 (a)
OneToMany
Species where no ortholog for RSRP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RSRP1 Gene

ENSEMBL:
Gene Tree for RSRP1 (if available)
TreeFam:
Gene Tree for RSRP1 (if available)

Paralogs for RSRP1 Gene

No data available for Paralogs for RSRP1 Gene

Variants for RSRP1 Gene

Sequence variations from dbSNP and Humsavar for RSRP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs121912762 Pathogenic 25,284,753(+) CACAC(C/T)GTTCA intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs121912763 Pathogenic 25,303,329(+) TTATG(G/T)GCACA intron-variant, nc-transcript-variant, reference, missense
rs879255550 other 25,290,757(+) TTTAG(A/G)CAACC intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1053355 untested 25,301,061(+) TCAGA(C/G)AGCAA intron-variant, nc-transcript-variant, reference, missense
rs1053356 untested 25,301,552(+) CAAGT(G/T)TCAAC intron-variant, nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RSRP1 Gene

Variant ID Type Subtype PubMed ID
dgv132n100 CNV gain 25217958
dgv133n100 CNV gain 25217958
dgv134n100 CNV gain 25217958
dgv135n100 CNV gain 25217958
esv3576582 CNV gain 25503493
nsv1160388 CNV duplication 26073780
nsv232 CNV deletion 15895083
nsv545825 CNV loss 21841781
nsv7298 CNV deletion 18451855

Variation tolerance for RSRP1 Gene

Residual Variation Intolerance Score: 65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.06; 68.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RSRP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RSRP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSRP1 Gene

Disorders for RSRP1 Gene

Relevant External Links for RSRP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RSRP1

No disorders were found for RSRP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RSRP1 Gene

Publications for RSRP1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. Elevated C1orf63 expression is correlated with CDK10 and predicts better outcome for advanced breast cancers: a retrospective study. (PMID: 26209438) Hong CQ … Cui YK (BMC cancer 2015) 3 60

Products for RSRP1 Gene

Sources for RSRP1 Gene

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