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Aliases for RSRC2 Gene

Aliases for RSRC2 Gene

  • Arginine/Serine-Rich Coiled-Coil 2 2 3

External Ids for RSRC2 Gene

Previous GeneCards Identifiers for RSRC2 Gene

  • GC12M121555
  • GC12M122989
  • GC12M119950

Summaries for RSRC2 Gene

GeneCards Summary for RSRC2 Gene

RSRC2 (Arginine/Serine-Rich Coiled-Coil 2) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSRC2 Gene

Genomics for RSRC2 Gene

Regulatory Elements for RSRC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RSRC2 Gene

122,503,458 bp from pter
122,527,013 bp from pter
23,556 bases
Minus strand

Genomic View for RSRC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RSRC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSRC2 Gene

Proteins for RSRC2 Gene

  • Protein details for RSRC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arginine/serine-rich coiled-coil protein 2
    Protein Accession:
    Secondary Accessions:
    • Q6N040
    • Q6NW16
    • Q9H864

    Protein attributes for RSRC2 Gene

    434 amino acids
    Molecular mass:
    50560 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14755.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW98327.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for RSRC2 Gene


neXtProt entry for RSRC2 Gene

Proteomics data for RSRC2 Gene at MOPED

Post-translational modifications for RSRC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RSRC2 Gene

Domains & Families for RSRC2 Gene

Protein Domains for RSRC2 Gene


Suggested Antigen Peptide Sequences for RSRC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RSRC2 family.
  • Belongs to the RSRC2 family.
genes like me logo Genes that share domains with RSRC2: view

No data available for Gene Families for RSRC2 Gene

Function for RSRC2 Gene

Gene Ontology (GO) - Molecular Function for RSRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with RSRC2: view

Phenotypes for RSRC2 Gene

genes like me logo Genes that share phenotypes with RSRC2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RSRC2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RSRC2 Gene

Localization for RSRC2 Gene

Subcellular locations from

Jensen Localization Image for RSRC2 Gene COMPARTMENTS Subcellular localization image for RSRC2 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RSRC2 Gene

Pathways & Interactions for RSRC2 Gene

SuperPathways for RSRC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RSRC2 Gene


No data available for Pathways by source and SIGNOR curated interactions for RSRC2 Gene

Drugs & Compounds for RSRC2 Gene

No Compound Related Data Available

Transcripts for RSRC2 Gene

Unigene Clusters for RSRC2 Gene

Arginine/serine-rich coiled-coil 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RSRC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RSRC2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a ·
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - - - - - - -
SP12: - - - - - - - - - -
SP13: - - - -
SP14: - - - - - -

ExUns: 11b ^ 12 ^ 13 ^ 14a · 14b · 14c

Relevant External Links for RSRC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RSRC2 Gene

mRNA expression in normal human tissues for RSRC2 Gene

Protein differential expression in normal tissues from HIPED for RSRC2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.2), Testis (8.8), and Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RSRC2 Gene

SOURCE GeneReport for Unigene cluster for RSRC2 Gene Hs.432996

genes like me logo Genes that share expression patterns with RSRC2: view

Protein tissue co-expression partners for RSRC2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RSRC2 Gene

Orthologs for RSRC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RSRC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Rsrc2 16
Rsrc2 36
  • 96 (a)
(Bos Taurus)
Mammalia RSRC2 36
  • 98 (a)
(Canis familiaris)
Mammalia RSRC2 36
  • 99 (a)
(Monodelphis domestica)
Mammalia RSRC2 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia RSRC2 36
  • 96 (a)
(Pan troglodytes)
Mammalia RSRC2 36
  • 100 (a)
(Gallus gallus)
Aves RSRC2 36
  • 89 (a)
(Anolis carolinensis)
Reptilia RSRC2 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10041 35
African clawed frog
(Xenopus laevis)
Amphibia flj11021-prov 35
(Danio rerio)
Actinopterygii rsrc2 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6340 36
  • 23 (a)
Species with no ortholog for RSRC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RSRC2 Gene

Gene Tree for RSRC2 (if available)
Gene Tree for RSRC2 (if available)

Paralogs for RSRC2 Gene

(1) SIMAP similar genes for RSRC2 Gene using alignment to 6 proteins: Pseudogenes for RSRC2 Gene

genes like me logo Genes that share paralogs with RSRC2: view

No data available for Paralogs for RSRC2 Gene

Variants for RSRC2 Gene

Sequence variations from dbSNP and Humsavar for RSRC2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs10998 -- 122,504,865(-) ACTTA(C/T)TAAAA utr-variant-3-prime, nc-transcript-variant
rs14519 -- 122,505,264(+) CAGCT(C/T)TTATA utr-variant-3-prime, nc-transcript-variant
rs1115154 -- 122,505,495(+) AGTCT(A/G)TAAGT utr-variant-3-prime, nc-transcript-variant
rs1499681 -- 122,504,232(-) TGGCT(C/T)TCCTT downstream-variant-500B
rs1532578 -- 122,511,674(-) GGTTT(C/G)CTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RSRC2 Gene

Variant ID Type Subtype PubMed ID
nsv899570 CNV Gain 21882294
esv2574323 CNV Deletion 19546169
esv2279643 CNV Deletion 18987734
esv1004502 CNV Deletion 20482838
esv5088 CNV Deletion 18987735
esv2746498 CNV Deletion 23290073
esv993685 CNV Deletion 20482838
esv2501949 CNV Deletion 19546169
esv9727 CNV Loss 19470904
esv1035767 CNV Deletion 17803354
nsv53703 CNV Loss 16902084

Variation tolerance for RSRC2 Gene

Residual Variation Intolerance Score: 10.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RSRC2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSRC2 Gene

Disorders for RSRC2 Gene

Relevant External Links for RSRC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RSRC2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RSRC2 Gene

Publications for RSRC2 Gene

  1. A novel gene, RSRC2, inhibits cell proliferation and affects survival in esophageal cancer patients. (PMID: 17203224) Kurehara H. … Kuwabara Y. (Int. J. Oncol. 2007) 2 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 67
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 67

Products for RSRC2 Gene

Sources for RSRC2 Gene

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