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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RSRC2 Gene

protein-coding   GIFtS: 47
GCID: GC12M122989

Arginine/Serine-Rich Coiled-Coil 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Arginine/Serine-Rich Coiled-Coil 21 2
Arginine/Serine-Rich Coiled-Coil Protein 22

External Ids:    HGNC: 305591   Entrez Gene: 651172   Ensembl: ENSG000001110117   UniProtKB: Q7L4I23   
ORGUL members:         
NONCODE14:n410007      

Export aliases for RSRC2 gene to outside databases

Previous GC identifers: GC12M121555 GC12M119950


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RSRC2 Gene: 
RSRC2 (arginine/serine-rich coiled-coil 2) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with RSRC2 include esophageal cancer, and esophagitis.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009755.19  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RSRC2 gene promoter:
         Max1   Elk-1   Lmo2   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRSRC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RSRC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RSRC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

RSRC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RSRC2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M122989:  view genomic region     (about GC identifiers)

Start:
122,989,190 bp from pter      End:
123,011,560 bp from pter
Size:
22,371 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RSRC2_HUMAN, Q7L4I2 (See protein sequence)
Recommended Name: Arginine/serine-rich coiled-coil protein 2  
Size: 434 amino acids; 50560 Da
Sequence caution: Sequence=BAB14755.1; Type=Erroneous initiation; Sequence=EAW98327.1; Type=Erroneous gene model
prediction;
Secondary accessions: Q6N040 Q6NW16 Q9H864
Alternative splicing: 2 isoforms:  Q7L4I2-1   Q7L4I2-2   

Explore the universe of human proteins at neXtProt for RSRC2: NX_Q7L4I2

Explore proteomics data for RSRC2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7L4I2

  • RSRC2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RSRC2 Protein Expression
    REFSEQ proteins: NP_075388.2  
    ENSEMBL proteins: 
     ENSP00000330188   ENSP00000412148   ENSP00000436515   ENSP00000343315   ENSP00000444159  
     ENSP00000432725   ENSP00000446470   ENSP00000445664   ENSP00000346678  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026760 RSRC2

    Graphical View of Domain Structure for InterPro Entry Q7L4I2

    ProtoNet protein and cluster: Q7L4I2

    UniProtKB/Swiss-Prot: RSRC2_HUMAN, Q7L4I2
    Similarity: Belongs to the RSRC2 family


    RSRC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         2 GenomeRNAi human phenotypes for RSRC2:
     Decreased Wnt reporter activit  Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RSRC2 
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    SwitchGear 3'UTR luciferase reporter plasmidRSRC2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RSRC2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for RSRC2 (Q7L4I22, 3 ENSP000003301884) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2876124 I2D: score=3 STRING: ENSP00000357292
    DEDDO756183I2D: score=1 
    JMJD6ENSP000003940854STRING: ENSP00000394085
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RSRC2

    Search CenterWatch for drugs/clinical trials and news about RSRC2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RSRC2 gene (3 alternative transcripts): 
    NM_198261.2  NM_198262.2  NM_023012.5  

    Unigene Cluster for RSRC2:

    Arginine/serine-rich coiled-coil 2
    Hs.432996  [show with all ESTs]
    Unigene Representative Sequence: NR_036435
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000331738(uc001uco.3 uc001ucp.3 uc001ucs.3 uc001uct.3 uc001ucr.3)
    ENST00000433877 ENST00000532695(uc021rfm.1) ENST00000527173 ENST00000392442
    ENST00000525332 ENST00000531389 ENST00000525335 ENST00000344591 ENST00000528263
    ENST00000527399 ENST00000524399 ENST00000527796 ENST00000526560 ENST00000527461
    ENST00000531639 ENST00000532186 ENST00000525387
    miRNA
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    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate RSRC2 (see all 36):
    hsa-miR-21* hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-548k hsa-miR-624 hsa-miR-124 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidRSRC2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RSRC2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RSRC2
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSRC2
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                         Customized lentivirus expression plasmids for stable overexpression of RSRC2 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RSRC2

    Additional mRNA sequence: 

    AB212664.1 AF161432.1 AK001883.1 AK023985.1 AK056114.1 AK056256.1 AK094465.1 BC008684.1 
    BC067773.1 BX640711.1 BX647884.1 HM245396.1 NR_036434.1 NR_036435.1 NR_036436.1 

    24/29 DOTS entries (see all 29):

    DT.447156  DT.91773391  DT.91773395  DT.100029725  DT.101984861  DT.317106  DT.91773386  DT.95097048 
    DT.100029724  DT.91773393  DT.100642253  DT.447155  DT.100644903  DT.121181836  DT.87014958  DT.100029726 
    DT.100871212  DT.121181812  DT.121181842  DT.75197282  DT.91773385  DT.95097013  DT.95097017  DT.95097020 

    24/387 AceView cDNA sequences (see all 387):

    BE218534 AI634388 AA598619 CR615900 CB111791 AI806020 AA283875 AA455805 
    AI761126 BX420060 AA919147 AA400847 AU142579 BX112031 BG006240 AA706077 
    AI126835 AA281547 AA594328 AI879179 AI806026 AW368199 BG178024 CA446259 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for RSRC2 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a ·
    SP1:                                      -     -     -     -                       -     -     -                 -     -                                       
    SP2:                                      -     -     -     -                       -     -     -                 -                                             
    SP3:                                      -     -     -     -                       -     -     -     -     -     -     -                                       
    SP4:                                      -     -     -     -                       -     -     -     -     -     -                                             
    SP5:                                                        -                             -     -     -     -     -     -                                       

    ExUns: 11b ^ 12 ^ 13 ^ 14a · 14b · 14c
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for RSRC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RSRC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTATTCAG
    RSRC2 Expression
    About this image


    See RSRC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RSRC2

    SOURCE GeneReport for Unigene cluster: Hs.432996
        SABiosciences Custom PCR Arrays for RSRC2
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RSRC2 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rsrc21 , 5 arginine/serine-rich coiled-coil 21, 5 90.15(n)1
    96.54(a)1
      5 (63.15 cM)5
    2086061  NM_001005525.11  NP_001005525.11 
     1237284265 
    chicken
    (Gallus gallus)
    Aves RSRC21 arginine/serine-rich coiled-coil 2 84.06(n)
    94.2(a)
      416864  XM_003642180.1  XP_003642228.1 
    lizard
    (Anolis carolinensis)
    Reptilia RSRC26
    arginine/serine-rich coiled-coil 2
    91(a)
    1 ↔ 1
    GL343423.1(210271-226628)
    African clawed frog
    (Xenopus laevis)
    Amphibia flj11021-prov2 putative nuclear protein 81.31(n)    BC041722.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rsrc21 arginine/serine-rich coiled-coil 2 66.08(n)
    72.66(a)
      406566  NM_213280.1  NP_998445.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG63401 CG6340 40.43(n)
    37.44(a)
      32482  NM_132806.2  NP_573034.1 


    ENSEMBL Gene Tree for RSRC2 (if available)
    TreeFam Gene Tree for RSRC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RSRC2 gene
    1 SIMAP similar gene for RSRC2 using alignment to 6 protein entries:     RSRC2_HUMAN (see all proteins):
    FLJ11021

    RSRC2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RSRC2
    PGOHUM00000258999


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/462 SNPs in RSRC2 are shown (see all 462)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs123029081,2
    C,F--122988710(+) TCTTAT/CTCCTG 4 -- ds50014Minor allele frequency- C:0.33NA WA 124
    rs1149821491,2
    F--122988763(+) TCCAAA/GGGATT 4 -- ds50011Minor allele frequency- G:0.03WA 118
    rs14996811,2
    C,F,H--122988779(-) TGGCTT/CTCCTT 4 -- ds500117Minor allele frequency- C:0.10MN NS EA NA CSA WA 2146
    rs42377891,2
    C,F,A,H--122988800(+) CTTTGC/TTGTAA 4 -- ds500121Minor allele frequency- T:0.47NS EA NA WA CSA 2338
    rs1480093041,2
    C--122988835(+) TGCAGA/GCCCCC 4 -- ds50010--------
    rs2000517041,2
    --122988836(+) GCAGG-/CCCCCC 4 -- ds50010--------
    rs128185521,2
    C,F--122988843(+) CCCCCC/AACCCC 4 -- ds50016Minor allele frequency- A:0.34NA CSA EA 248
    rs1153780361,2
    F--122988874(+) AATCTA/GGTAAC 4 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1129374011,2
    C,F--122988928(+) CCGGCC/ACTTTG 4 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1459978291,2
    --122989161(+) CAGAGA/CAAGAT 4 -- ds50010--------

    HapMap Linkage Disequilibrium report for RSRC2 (122989190 - 123011560 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for RSRC2 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1035767CNV Deletion17803354
    esv2279643CNV Deletion18987734
    esv2574323CNV Deletion19546169
    esv1004502CNV Deletion20482838
    esv993685CNV Deletion20482838
    esv5088CNV Deletion18987735
    esv2746498CNV Deletion23290073
    esv2501949CNV Deletion19546169
    nsv53703CNV Loss16902084
    esv9727CNV Loss19470904

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for RSRC2:    About MalaCards
    esophageal cancer    esophagitis


    RSRC2 for disorders           About GeneDecksing


    Export disorders for RSRC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RSRC2 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with RSRC2)
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    1. A novel gene, RSRC2, inhibits cell proliferation and affects survival in esophageal cancer patients. (PubMed id 17203224)1, 3 Kurehara H....Kuwabara Y. (2007)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The Brd4 extraterminal domain confers transcription a ctivation independent of pTEFb by recruiting multiple proteins, including NSD3. (PubMed id 21555454)1 Rahman S....Howley P.M. (2011)
    4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    5. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    6. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    7. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)2 Beausoleil S.A.... Gygi S.P. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 65117 HGNC: 30559 AceView: FLJ11021 Ensembl:ENSG00000111011 euGenes: HUgn65117
    ECgene: RSRC2 H-InvDB: RSRC2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RSRC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RSRC2 gene:
    Search GeneIP for patents involving RSRC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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