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Aliases for RSRC2 Gene

Aliases for RSRC2 Gene

  • Arginine And Serine Rich Coiled-Coil 2 2 3 5
  • Arginine/Serine-Rich Coiled-Coil 2 2

External Ids for RSRC2 Gene

Previous GeneCards Identifiers for RSRC2 Gene

  • GC12M121555
  • GC12M122989
  • GC12M119950

Summaries for RSRC2 Gene

GeneCards Summary for RSRC2 Gene

RSRC2 (Arginine And Serine Rich Coiled-Coil 2) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

Additional gene information for RSRC2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSRC2 Gene

Genomics for RSRC2 Gene

Regulatory Elements for RSRC2 Gene

Enhancers for RSRC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H122919 1.2 ENCODE dbSUPER 139 -393.0 -392994 1.5 ZNF493 ZFP64 ZEB1 ZNF155 ZNF121 ZNF138 ZNF354C FOS KLF7 ZNF202 EIF2B1 RSRC2 DDX55 ZCCHC8 ENSG00000235423 ATP6V0A2 LOC101927415 C12orf65 TCTN2 OGFOD2
GH12H121783 1.9 FANTOM5 ENCODE dbSUPER 69.3 +731.0 731021 24.5 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NFYC MEF2D ZCCHC8 RSRC2 ENSG00000272849 PSMD9 SETD1B ANAPC5 KNTC1 LINC01089 HPD KDM2B
GH12H122427 0.8 dbSUPER 106.3 +99.3 99348 0.7 ZBTB21 ZNF493 ZNF140 ZNF266 CEBPG ZNF697 ZNF664 ZNF791 ZNF354C ZNF19 RSRC2 ZCCHC8 ENSG00000235423 ENSG00000272849 SETD1B C12orf65 KNTC1 OGFOD2 LINC01089 PSMD9
GH12H121887 1.2 ENCODE 69.5 +637.9 637922 2.3 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 MEF2D ZNF610 GLIS1 RCOR2 RSRC2 KNTC1 ZCCHC8 SETD1B ENSG00000272849 ANAPC5 PSMD9 LINC01089 SPPL3 IL31
GH12H123231 1.4 ENCODE dbSUPER 56.9 -706.5 -706504 3.7 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 RSRC2 ZCCHC8 DDX55 EIF2B1 KNTC1 CDK2AP1 LOC101927415 MPHOSPH9 OGFOD2 C12orf65
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RSRC2 on UCSC Golden Path with GeneCards custom track

Promoters for RSRC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for RSRC2 Gene

Genomic Locations for RSRC2 Gene
23,556 bases
Minus strand

Genomic View for RSRC2 Gene

Genes around RSRC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RSRC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RSRC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSRC2 Gene

Proteins for RSRC2 Gene

  • Protein details for RSRC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arginine/serine-rich coiled-coil protein 2
    Protein Accession:
    Secondary Accessions:
    • Q6N040
    • Q6NW16
    • Q9H864

    Protein attributes for RSRC2 Gene

    434 amino acids
    Molecular mass:
    50560 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14755.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW98327.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for RSRC2 Gene


neXtProt entry for RSRC2 Gene

Post-translational modifications for RSRC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for RSRC2
  • Santa Cruz Biotechnology (SCBT) Antibodies for RSRC2

No data available for DME Specific Peptides for RSRC2 Gene

Domains & Families for RSRC2 Gene

Gene Families for RSRC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RSRC2 Gene


Suggested Antigen Peptide Sequences for RSRC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RSRC2 family.
  • Belongs to the RSRC2 family.
genes like me logo Genes that share domains with RSRC2: view

Function for RSRC2 Gene

Phenotypes From GWAS Catalog for RSRC2 Gene

Gene Ontology (GO) - Molecular Function for RSRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
genes like me logo Genes that share ontologies with RSRC2: view
genes like me logo Genes that share phenotypes with RSRC2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RSRC2 Gene

Localization for RSRC2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RSRC2 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (4)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RSRC2 Gene

Pathways & Interactions for RSRC2 Gene

SuperPathways for RSRC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RSRC2 Gene


No data available for Pathways by source and SIGNOR curated interactions for RSRC2 Gene

Drugs & Compounds for RSRC2 Gene

No Compound Related Data Available

Transcripts for RSRC2 Gene

Unigene Clusters for RSRC2 Gene

Arginine/serine-rich coiled-coil 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RSRC2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a ·
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - - - - - - -
SP12: - - - - - - - - - -
SP13: - - - -
SP14: - - - - - -

ExUns: 11b ^ 12 ^ 13 ^ 14a · 14b · 14c

Relevant External Links for RSRC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RSRC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RSRC2 Gene

Protein differential expression in normal tissues from HIPED for RSRC2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.2), Testis (8.8), and Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RSRC2 Gene

Protein tissue co-expression partners for RSRC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RSRC2 Gene:


SOURCE GeneReport for Unigene cluster for RSRC2 Gene:


Evidence on tissue expression from TISSUES for RSRC2 Gene

  • Nervous system(4.8)
  • Intestine(4.3)
  • Lung(2.8)
  • Bone marrow(2.3)
  • Spleen(2.1)
  • Heart(2)
  • Kidney(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with RSRC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RSRC2 Gene

Orthologs for RSRC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RSRC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RSRC2 34
  • 100 (a)
(Canis familiaris)
Mammalia RSRC2 34
  • 99 (a)
(Bos Taurus)
Mammalia RSRC2 34
  • 98 (a)
(Monodelphis domestica)
Mammalia RSRC2 34
  • 98 (a)
(Mus musculus)
Mammalia Rsrc2 34
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia RSRC2 34
  • 96 (a)
(Gallus gallus)
Aves RSRC2 34
  • 89 (a)
(Anolis carolinensis)
Reptilia RSRC2 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10041 33
African clawed frog
(Xenopus laevis)
Amphibia flj11021-prov 33
(Danio rerio)
Actinopterygii rsrc2 34
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6340 34
  • 23 (a)
Species where no ortholog for RSRC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RSRC2 Gene

Gene Tree for RSRC2 (if available)
Gene Tree for RSRC2 (if available)

Paralogs for RSRC2 Gene

(1) SIMAP similar genes for RSRC2 Gene using alignment to 6 proteins: Pseudogenes for RSRC2 Gene

genes like me logo Genes that share paralogs with RSRC2: view

No data available for Paralogs for RSRC2 Gene

Variants for RSRC2 Gene

Sequence variations from dbSNP and Humsavar for RSRC2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000079184 -- 122,523,376(+) CCAAG(A/G)GTGGT intron-variant
rs1000098248 -- 122,514,656(+) ATAAT(A/G)TATTA intron-variant
rs1000234036 -- 122,504,318(+) TTTAT(A/G)TTCAA downstream-variant-500B
rs1000260379 -- 122,504,177(+) TCTTC(C/G)CTGAT downstream-variant-500B
rs1000267637 -- 122,528,041(+) AAAAC(-/AT)AAACT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RSRC2 Gene

Variant ID Type Subtype PubMed ID
nsv958634 CNV deletion 24416366
nsv53703 CNV deletion 16902084
nsv1150175 CNV deletion 26484159
nsv1113531 CNV deletion 24896259
nsv1070136 CNV deletion 25765185
nsv1041677 CNV gain 25217958
esv993685 CNV deletion 20482838
esv9727 CNV loss 19470904
esv5088 CNV loss 18987735
esv3549910 CNV deletion 23714750
esv3250940 CNV deletion 24192839
esv2746498 CNV deletion 23290073
esv2574323 CNV deletion 19546169
esv2501949 CNV deletion 19546169
esv2279643 CNV deletion 18987734
esv1035767 CNV deletion 17803354
esv1004502 CNV deletion 20482838

Variation tolerance for RSRC2 Gene

Residual Variation Intolerance Score: 10.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RSRC2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSRC2 Gene

Disorders for RSRC2 Gene

Relevant External Links for RSRC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RSRC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RSRC2 Gene

Publications for RSRC2 Gene

  1. A novel gene, RSRC2, inhibits cell proliferation and affects survival in esophageal cancer patients. (PMID: 17203224) Kurehara H … Kuwabara Y (International journal of oncology 2007) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60

Products for RSRC2 Gene

Sources for RSRC2 Gene

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