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RSRC1 Gene

protein-coding   GIFtS: 50
GCID: GC03P157823

Arginine/Serine-Rich Coiled-Coil 1

  See RSRC1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Arginine/Serine-Rich Coiled-Coil 11 2     Splicing Factor1
Arginine/Serine-Rich Coiled-Coil Protein 12 3     SFRS212
SRrp532 3     Serine/Arginine-Related Protein 532
SRRP533 5     Splicing Factor, Arginine/Serine-Rich 212
Arginine/Serine-Rich 211     

External Ids:    HGNC: 241521   Entrez Gene: 513192   Ensembl: ENSG000001748917   OMIM: 6133525   UniProtKB: Q96IZ73   

Export aliases for RSRC1 gene to outside databases

Previous GC identifers: GC03P159311 GC03P155224


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RSRC1 Gene:
This gene encodes a member of the serine and arginine rich-related protein family. The encoded protein is involved
in both constitutive and alternative mRNA splicing. This gene may be associated with schizophrenia. A pseudogene
of this gene is located on chromosome 9. Alternative splicing results in multiple transcript variants encoding
different isoforms. (provided by RefSeq, Nov 2012)

GeneCards Summary for RSRC1 Gene:
RSRC1 (arginine/serine-rich coiled-coil 1) is a protein-coding gene. Diseases associated with RSRC1 include schizophrenia.

UniProtKB/Swiss-Prot: RSRC1_HUMAN, Q96IZ7
Function: Plays a role in pre-mRNA splicing. Involved in both constitutive and alternative pre-mRNA splicing. May
have a role in the recognition of the 3' splice site during the second step of splicing




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RSRC1 gene promoter:
         Nkx2-5   CUTL1   POU3F2   PPAR-alpha   AREB6   MEF-2A   CP2   COMP1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRSRC1 promoter sequence
   Search Chromatin IP Primers for RSRC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RSRC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.32   Ensembl cytogenetic band:  3q25.32   HGNC cytogenetic band: 3q25.32

RSRC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RSRC1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P157823:  view genomic region     (about GC identifiers)

Start:
157,823,644 bp from pter      End:
158,263,519 bp from pter
Size:
439,876 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RSRC1_HUMAN, Q96IZ7 (See protein sequence)
Recommended Name: Serine/Arginine-related protein 53  
Size: 334 amino acids; 38677 Da
Subunit: Interacts (via Arg/Ser-rich domain) with LUC7L3, RBM39 and RSF1
Sequence caution: Sequence=AAF64267.1; Type=Frameshift; Positions=159, 166, 174, 178;
Secondary accessions: A8K2R9 Q96QK2 Q9NZE5
Alternative splicing: 2 isoforms:  Q96IZ7-1   Q96IZ7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RSRC1: NX_Q96IZ7

Explore proteomics data for RSRC1 at MOPED

Post-translational modifications: 

  • Phosphorylated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RSRC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001258763.1  NP_001258767.1  NP_057709.2  

    ENSEMBL proteins: 
     ENSP00000420150   ENSP00000417690   ENSP00000295930   ENSP00000417302   ENSP00000419794  
     ENSP00000308671   ENSP00000417816   ENSP00000420018   ENSP00000419394   ENSP00000419054  
     ENSP00000420464  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q96IZ7


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RSRC1_HUMAN, Q96IZ7
    Function: Plays a role in pre-mRNA splicing. Involved in both constitutive and alternative pre-mRNA splicing. May
    have a role in the recognition of the 3' splice site during the second step of splicing

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15798186
         
    Find genes that share ontologies with RSRC1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RSRC1
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    hsa-mir-30a-3p (MIRT049910), hsa-mir-192-5p (MIRT026535), hsa-mir-215-5p (MIRT024693)

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    2 qRT-PCR Assays for microRNAs that regulate RSRC1:
    hsa-miR-33a* hsa-miR-548d-3p
    SwitchGear 3'UTR luciferase reporter plasmidRSRC1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RSRC1_HUMAN, Q96IZ7: Nucleus (By similarity). Nucleus speckle (By similarity). Cytoplasm (By similarity).
    Note=Shuttles between the nucleus and cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0016607nuclear speck ISS--

    Find genes that share ontologies with RSRC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RSRC1
    Interactions:

        Search GeneGlobe Interaction Network for RSRC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RSRC1 (Q96IZ72, 3 ENSP000002959304) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000224979Q9Y3332, 3, ENSP000004140064MINT-65198 I2D: score=5 STRING: ENSP00000414006
    LSM2Q9Y3332, 3, ENSP000003648134MINT-65198 I2D: score=5 STRING: ENSP00000364813
    ENSG00000172850Q9Y3332, 3MINT-65198 I2D: score=5 
    ENSG00000225998Q9Y3332, 3MINT-65198 I2D: score=5 
    ENSG00000231502Q9Y3332, 3MINT-65198 I2D: score=5 
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    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000380alternative mRNA splicing, via spliceosome IEA--
    GO:0000398mRNA splicing, via spliceosome IDA15798186
    GO:0006468protein phosphorylation IEA--
    GO:0006913nucleocytoplasmic transport ISS--
    GO:0008380RNA splicing IDA15798186

    Find genes that share ontologies with RSRC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for RSRC1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RSRC1 gene (3 alternative transcripts): 
    NM_001271834.1  NM_001271838.1  NM_016625.3  

    Unigene Cluster for RSRC1:

    Arginine/serine-rich coiled-coil 1
    Hs.591283  [show with all ESTs]
    Unigene Representative Sequence: NM_001271838
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000480820 ENST00000494002 ENST00000295930(uc003fbt.3 uc003fbu.1)
    ENST00000471994 ENST00000464171 ENST00000312179(uc003fbv.3) ENST00000475278
    ENST00000480119 ENST00000468344 ENST00000471911(uc011bou.1) ENST00000476899
    ENST00000477788 ENST00000482822 ENST00000496268
    miRNA
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    hsa-miR-33a* hsa-miR-548d-3p
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    Additional mRNA sequence: 

    AF208853.1 AK290334.1 AK300388.1 BC006982.1 BC010357.1 

    11 DOTS entries:

    DT.306667  DT.120848465  DT.91789214  DT.99934270  DT.102840890  DT.120848468  DT.95168103  DT.120848454 
    DT.40245897  DT.91915183  DT.92410035 

    Selected AceView cDNA sequences (see all 90):

    BX101668 BP349541 CA448335 AW960143 BM754311 AA620664 AA548531 NM_016625 
    BC006982 BG184516 CB129497 BM799955 CA771035 AA620642 BC010357 BU193270 
    BP358994 AW875886 AA969502 BG214634 BG212522 CA771336 BF110025 BG494867 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RSRC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAAGAACA
    RSRC1 Expression
    About this image

    RSRC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RSRC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591283
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RSRC1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rsrc11 , 5 arginine/serine-rich coiled-coil 11, 5 88.83(n)1
    90.91(a)1
      3 (30.77 cM)5
    668801  NM_025822.31  NP_080098.11 
     669813905 
    chicken
    (Gallus gallus)
    Aves RSRC16
    arginine/serine-rich coiled-coil 1
    80(a)
    1 ↔ 1
    9(21958768-22066377)
    lizard
    (Anolis carolinensis)
    Reptilia RSRC16
    arginine/serine-rich coiled-coil 1
    77(a)
    1 ↔ 1
    3(14184330-14419369)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.238602 Xenopus laevis transcribed sequence with weak similarity more 78.63(n)    BX850107.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rsrc16
    arginine/serine-rich coiled-coil 1
    56(a)
    1 ↔ 1
    15(2179535-2404741) ENSDARG00000033987


    ENSEMBL Gene Tree for RSRC1 (if available)
    TreeFam Gene Tree for RSRC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RSRC1 gene

    Find genes that share paralogs with RSRC1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RSRC1
    PGOHUM00000236246


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RSRC1 (see all 8151)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs604799281,2
    C--155298839(+) AAAAA-/A/AA  
            
    CAAAA
    3 -- int11NA 2
    rs350797761,2
    C--155436142(+) TCCTC-/CTCTTCTT 3 -- int11Minor allele frequency- CTC:0.00NA 2
    rs605893901,2
    C--155489952(+) TATTA-/TTAACTTA 3 -- int11Minor allele frequency- TTA:0.00NA 2
    rs1920317401,2
    --157806623(+) CTTCCA/GTATAT 3 -- us2k10--------
    rs1140384751,2
    F--157826068(+) AGAAAC/TGTTGT 3 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1489867101,2
    --157826165(+) AATACA/GTTGTT 3 -- us2k10--------
    rs1454080691,2
    --157826175(+) TATCAA/GTACTT 3 -- us2k10--------
    rs1827715941,2
    --157826438(+) CAAATA/GACTCA 3 -- us2k10--------
    rs1870962691,2
    --157826590(+) TCAGGA/GAAGTC 3 -- us2k10--------
    rs76424891,2
    C,F,H--157826629(+) CAATAG/AATTTT 3 -- us2k119Minor allele frequency- A:0.02NS NA WA CSA EA 1139

    HapMap Linkage Disequilibrium report for RSRC1 (157823644 - 158073644 bp, first 250kb of RSRC1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RSRC1 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2357327CNV Deletion18987734
    dgv892e199CNV Deletion23128226
    esv2502281CNV Deletion19546169
    esv2726099CNV Deletion23290073
    esv274065CNV Insertion20981092
    esv267789CNV Insertion20981092
    esv1640604CNV Insertion17803354
    esv270915CNV Insertion20981092
    esv274575CNV Insertion20981092
    esv271638CNV Insertion20981092

    Human Gene Mutation Database (HGMD): RSRC1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RSRC1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613352    OMIM disorders: --

    1 disease for RSRC1:    
    About MalaCards
    schizophrenia


    Find genes that share disorders with RSRC1           About GenesLikeMe

    Genetic Association Database (GAD): RSRC1
    Human Genome Epidemiology (HuGE) Navigator: RSRC1 (6 documents)

    Export disorders for RSRC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RSRC1 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with RSRC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia. (PubMed id 19065146)1, 3, 4 Potkin S.G....Macciardi F. (Mol. Psychiatry 2009)
    2. A novel SR-related protein is required for the second step of pre- mRNA splicing. (PubMed id 15798186)1, 2, 3 Cazalla D.... Caceres J.F. (Mol. Cell. Biol. 2005)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PubMed id 23563607)1 Berndt S.I....Ingelsson E. (Nat. Genet. 2013)
    7. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    8. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Identifying gene regulatory networks in schizophrenia. (PubMed id 20600988)1 Potkin S.G....Xie X. (Neuroimage 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51319 HGNC: 24152 AceView: MGC12197 Ensembl:ENSG00000174891 euGenes: HUgn51319
    ECgene: RSRC1 H-InvDB: RSRC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RSRC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RSRC1 gene:
    Search GeneIP for patents involving RSRC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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