RSRC1 Gene
protein-coding GIFtS: 46
GCID: GC03P157823
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arginine/serine-rich coiled-coil 1
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Aliases
for RSRC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Arginine/Serine-Rich Coiled-Coil 11 2 | | BM-0111 | | SRrp531 2 3 | | MGC121971 | | SFRS211 2 | | Serine/Arginine-Related Protein 532 | | Arginine/Serine-Rich Coiled-Coil Protein 12 3 | | Splicing Factor, Arginine/Serine-Rich 212 | | SRRP533 5 | | |
Export aliases for RSRC1 gene to outside databasesPrevious GC identifers: GC03P159311 GC03P155224 |
Summaries
for RSRC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RSRC1:
This gene encodes a member of the serine and arginine rich-related protein family. The encoded protein is involved inboth constitutive and alternative mRNA splicing. This gene may be associated with schizophrenia. A pseudogene of thisgene is located on chromosome 9. Alternative splicing results in multiple transcript variants encoding differentisoforms. (provided by RefSeq, Nov 2012)
UniProtKB/Swiss-Prot: RSRC1_HUMAN, Q96IZ7Function: Plays a role in pre-mRNA splicing. Involved in both constitutive and alternative pre-mRNA splicing. May havea role in the recognition of the 3' splice site during the second step of splicing
|
Genomic Views
for RSRC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RSRC1 gene promoter:
Nkx2-5 CUTL1 POU3F2 PPAR-alpha AREB6 MEF-2A CP2 COMP1 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RSRC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RSRC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q25.32 Ensembl cytogenetic band: 3q25.32 HGNC cytogenetic band: 3q25.32RSRC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P157823: view genomic region
(about GC identifiers)
Start:
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157,823,644 bp from pter |
End:
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158,263,519 bp from pter |
Size:
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439,876 bases |
Orientation:
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plus strand |
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Proteins
for RSRC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RSRC1_HUMAN, Q96IZ7 (See
protein sequence)Recommended Name: Serine/Arginine-related protein 53 Size: 334 amino acids; 38677 Da
Subunit: Interacts (via Arg/Ser-rich domain) with LUC7L3, RBM39 and RSF1
Subcellular location: Nucleus (By similarity). Nucleus speckle (By similarity). Cytoplasm (By similarity).Note=Shuttles between the nucleus and cytoplasm (By similarity)
Sequence caution: Sequence=AAF64267.1; Type=Frameshift; Positions=159, 166, 174, 178;
Secondary accessions: A8K2R9 Q96QK2 Q9NZE5Alternative splicing: 2 isoforms: Q96IZ7-1 Q96IZ7-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RSRC1: NX_Q96IZ7
Post-translational modifications:
Phosphorylated (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96IZ7
RSRC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001258763.1 NP_001258767.1 NP_057709.2
ENSEMBL proteins: ENSP00000420150 ENSP00000417690 ENSP00000295930 ENSP00000417302 ENSP00000419794 ENSP00000308671 ENSP00000417816 ENSP00000420018 ENSP00000419394 ENSP00000419054 ENSP00000420464
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RSRC1 for ontologies About GeneDecksing
RSRC1 Antibody Products:
Assay Products for RSRC1: |
Protein
Domains /
Families
for RSRC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96IZ7 |
Function
for RSRC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RSRC1_HUMAN, Q96IZ7Function: Plays a role in pre-mRNA splicing. Involved in both constitutive and alternative pre-mRNA splicing. May havea role in the recognition of the 3' splice site during the second step of splicing
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RSRC1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RSRC1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for RSRC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSRC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSRC1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
RSRC1 for ontologies About GeneDecksing
|
Pathways & Interactions
for RSRC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RSRC1
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/12 Interacting proteins for RSRC1 (Q96IZ72, 3 ENSP000002959304) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
RSRC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for RSRC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RSRC1
Search CenterWatch for drugs/clinical trials and news about RSRC1
|
Transcripts
for RSRC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RSRC1 gene (3 alternative transcripts): NM_001271834.1 NM_001271838.1 NM_016625.3 Unigene Cluster for RSRC1: Arginine/serine-rich coiled-coil 1 Hs.591283 [show with all ESTs]Unigene Representative Sequence: NM_00127183814 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000480820 ENST00000494002 ENST00000295930(uc003fbt.3 uc003fbu.1)
ENST00000471994 ENST00000464171 ENST00000312179(uc003fbv.3) ENST00000475278
ENST00000480119 ENST00000468344 ENST00000471911(uc011bou.1) ENST00000476899
ENST00000477788 ENST00000482822 ENST00000496268
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RSRC1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RSRC1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RSRC1 (NM_016625) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RSRC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSRC1 |
Additional cDNA sequence: AF208853.1 AK290334.1 AK300388.1 BC006982.1 BC010357.1 11 DOTS entries: DT.306667 DT.120848465 DT.91789214 DT.99934270 DT.102840890 DT.120848468 DT.95168103 DT.120848454 DT.40245897 DT.91915183 DT.92410035 24/90 AceView cDNA sequences (see all 90): BX101668 BU193270 BC010357 AA620642 CA771035 BM799955 CB129497 BG184516 BC006982 NM_016625 AA620664 AA548531 BM754311 AW960143 CA448335 BP349541 AL601595 BG207268 BQ435722 BG200023 BU945436 AW084175 BG674990 BG212521
GeneLoc Exon Structure
|
Expression
for RSRC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RSRC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAAAGAACA
About this image
See RSRC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RSRC1
SOURCE GeneReport for Unigene cluster: Hs.591283
SABiosciences Custom PCR Arrays for RSRC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RSRC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RSRC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RSRC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RSRC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSRC1 |
Orthologs
for RSRC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RSRC1 gene from 6/22 species (see all 22) About this table
ENSEMBL Gene Tree for RSRC1 (if available)
TreeFam Gene Tree for RSRC1 (if available) |
Paralogs
for RSRC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RSRC1 gene
- CLASRP2 SON2 C1orf632
RSRC1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for RSRC1
PGOHUM00000236246
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Genomic Variants
for RSRC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RSRC1 (157823644 - 158073644 bp, first 250kb of RSRC1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for RSRC1
2 CNVs: 63627 98501
4 Indels: 50975 46315 62117 60442
Human Gene Mutation Database (HGMD): RSRC1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RSRC1 |
|
Disorders
/ Diseases
for RSRC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RSRC1 for disorders About GeneDecksing
OMIM gene information: 613352
OMIM disorders: --
1  disease for RSRC1: About MalaCardsschizophrenia
Human Genome Epidemiology (HuGE) Navigator: RSRC1 (6 documents)
Export disorders for RSRC1 gene to outside databases
|
Publications
for RSRC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RSRC1 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with RSRC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel SR-related protein is required for the second step of Pre-mRNA splicing. (PubMed id 15798186)1, 2, 3 Cazalla D....Caceres J.F. (2005)
- Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia. (PubMed id 19065146)1, 3 Potkin S.G....Macciardi F. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- The Brd4 extraterminal domain confers transcription a ctivation independent of pTEFb by recruiting multiple proteins, including NSD3. (PubMed id 21555454)1 Rahman S....Howley P.M. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Identifying gene regulatory networks in schizophrenia . (PubMed id 20600988)1 Potkin S.G....Xie X. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
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External Searches for RSRC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RSRC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RSRC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RSRC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RSRC1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RSRC1 gene:
Search GeneIP for patents involving RSRC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RSRC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for RSRC1 | | OriGene shRNA RFP for RSRC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RSRC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RSRC1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RSRC1 | | OriGene 3'-UTR Clone for RSRC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RSRC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RSRC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RSRC1 | | OriGene Custom Protein Services for RSRC1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RSRC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RSRC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RSRC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RSRC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RSRC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RSRC1 |
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| | | | Search Tocris compounds for RSRC1 |
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 | | | RSRC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSRC1 |
|  |  |  | | | | ThermoFisher Antibodies for RSRC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSRC1 |
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