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Aliases for RSRC1 Gene

Aliases for RSRC1 Gene

  • Arginine/Serine-Rich Coiled-Coil 1 2 3
  • SRrp53 3 4 6
  • Arginine/Serine-Rich Coiled-Coil Protein 1 3 4
  • Splicing Factor, Arginine/Serine-Rich 21 3
  • Serine/Arginine-Related Protein 53 3
  • Arginine/Serine-Rich 21 2
  • Splicing Factor 2
  • BM-011 3
  • SFRS21 3

External Ids for RSRC1 Gene

Summaries for RSRC1 Gene

Entrez Gene Summary for RSRC1 Gene

  • This gene encodes a member of the serine and arginine rich-related protein family. The encoded protein is involved in both constitutive and alternative mRNA splicing. This gene may be associated with schizophrenia. A pseudogene of this gene is located on chromosome 9. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

GeneCards Summary for RSRC1 Gene

RSRC1 (Arginine/Serine-Rich Coiled-Coil 1) is a Protein Coding gene. Diseases associated with RSRC1 include schizophrenia.

UniProtKB/Swiss-Prot for RSRC1 Gene

  • Plays a role in pre-mRNA splicing. Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3 splice site during the second step of splicing.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSRC1 Gene

Genomics for RSRC1 Gene

Genomic Location for RSRC1 Gene

Start:
158,105,855 bp from pter
End:
158,545,730 bp from pter
Size:
439,876 bases
Orientation:
Plus strand

Genomic View for RSRC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RSRC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSRC1 Gene

Regulatory Elements for RSRC1 Gene

Proteins for RSRC1 Gene

  • Protein details for RSRC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IZ7-RSRC1_HUMAN
    Recommended name:
    Serine/Arginine-related protein 53
    Protein Accession:
    Q96IZ7
    Secondary Accessions:
    • A8K2R9
    • Q96QK2
    • Q9NZE5

    Protein attributes for RSRC1 Gene

    Size:
    334 amino acids
    Molecular mass:
    38677 Da
    Quaternary structure:
    • Interacts (via Arg/Ser-rich domain) with LUC7L3, RBM39 and RSF1.
    SequenceCaution:
    • Sequence=AAF64267.1; Type=Frameshift; Positions=159, 166, 174, 178; Evidence={ECO:0000305};

    Alternative splice isoforms for RSRC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RSRC1 Gene

Proteomics data for RSRC1 Gene at MOPED

Post-translational modifications for RSRC1 Gene

No data available for DME Specific Peptides for RSRC1 Gene

Domains for RSRC1 Gene

Protein Domains for RSRC1 Gene

ProtoNet:
genes like me logo Genes that share domains with RSRC1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for RSRC1 Gene

Function for RSRC1 Gene

Molecular function for RSRC1 Gene

UniProtKB/Swiss-Prot Function: Plays a role in pre-mRNA splicing. Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3 splice site during the second step of splicing.

Gene Ontology (GO) - Molecular Function for RSRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15798186
genes like me logo Genes that share ontologies with RSRC1: view

miRNA for RSRC1 Gene

miRTarBase miRNAs that target RSRC1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RSRC1 Gene

Localization for RSRC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RSRC1 Gene

Nucleus. Nucleus speckle. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RSRC1 Gene COMPARTMENTS Subcellular localization image for RSRC1 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for RSRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0016607 nuclear speck ISS --
genes like me logo Genes that share ontologies with RSRC1: view

Pathways for RSRC1 Gene

SuperPathways for RSRC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RSRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000380 alternative mRNA splicing, via spliceosome IEA --
GO:0000398 mRNA splicing, via spliceosome IDA 15798186
GO:0006468 protein phosphorylation IEA --
GO:0006913 nucleocytoplasmic transport ISS --
GO:0008380 RNA splicing IDA 15798186
genes like me logo Genes that share ontologies with RSRC1: view

No data available for Pathways by source for RSRC1 Gene

Transcripts for RSRC1 Gene

Unigene Clusters for RSRC1 Gene

Arginine/serine-rich coiled-coil 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RSRC1 Gene

No ASD Table

Relevant External Links for RSRC1 Gene

GeneLoc Exon Structure for
RSRC1
ECgene alternative splicing isoforms for
RSRC1

Expression for RSRC1 Gene

mRNA expression in normal human tissues for RSRC1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RSRC1 Gene

SOURCE GeneReport for Unigene cluster for RSRC1 Gene Hs.591283

genes like me logo Genes that share expressions with RSRC1: view

Orthologs for RSRC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RSRC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RSRC1 36
  • 99.8 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia RSRC1 36
  • 93.11 (n)
  • 95.81 (a)
RSRC1 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RSRC1 36
  • 91.92 (n)
  • 94.61 (a)
RSRC1 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rsrc1 36
  • 88.83 (n)
  • 90.91 (a)
Rsrc1 16
Rsrc1 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RSRC1 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RSRC1 37
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rsrc1 36
  • 87.52 (n)
  • 92.81 (a)
chicken
(Gallus gallus)
Aves RSRC1 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RSRC1 37
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23860 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2949 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1259 36
zebrafish
(Danio rerio)
Actinopterygii rsrc1 37
  • 56 (a)
OneToOne
Species with no ortholog for RSRC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RSRC1 Gene

ENSEMBL:
Gene Tree for RSRC1 (if available)
TreeFam:
Gene Tree for RSRC1 (if available)

Paralogs for RSRC1 Gene

Pseudogenes.org Pseudogenes for RSRC1 Gene

genes like me logo Genes that share paralogs with RSRC1: view

No data available for Paralogs for RSRC1 Gene

Variants for RSRC1 Gene

Sequence variations from dbSNP and Humsavar for RSRC1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs325837 -- 158,424,658(+) ggtac(C/T)ggctt intron-variant
rs696715 -- 158,223,444(-) tgaca(C/T)gtatg intron-variant
rs698975 -- 158,221,590(-) GATTA(C/T)TAATG intron-variant
rs698976 -- 158,221,420(-) GCATA(A/C)CATGT intron-variant
rs698977 -- 158,221,409(-) TTCTC(A/C)TCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RSRC1 Gene

Variant ID Type Subtype PubMed ID
nsv829768 CNV Gain 17160897
esv8211 CNV Gain 19470904
esv274065 CNV Insertion 20981092
esv267789 CNV Insertion 20981092
nsv877689 CNV Loss 21882294
esv1640604 CNV Insertion 17803354
esv271638 CNV Insertion 20981092
esv274575 CNV Insertion 20981092
esv28868 CNV Loss 19812545
esv270915 CNV Insertion 20981092
esv2502281 CNV Deletion 19546169
esv2357327 CNV Deletion 18987734
esv2726099 CNV Deletion 23290073
esv6140 CNV Loss 19470904
dgv892e199 CNV Deletion 23128226
nsv520244 CNV Loss 19592680
nsv877690 CNV Gain 21882294
esv271278 CNV Insertion 20981092
nsv877691 CNV Gain 21882294

Relevant External Links for RSRC1 Gene

HapMap Linkage Disequilibrium report
RSRC1

Disorders for RSRC1 Gene

(1) MalaCards Diseases for RSRC1 Gene

Search for RSRC1 Gene in MalaCards »

Relevant External Links for RSRC1

Genetic Association Database (GAD)
RSRC1
Human Genome Epidemiology (HuGE) Navigator
RSRC1
genes like me logo Genes that share disorders with RSRC1: view

No data available for UniProtKB/Swiss-Prot for RSRC1 Gene

Publications for RSRC1 Gene

  1. A novel SR-related protein is required for the second step of pre- mRNA splicing. (PMID: 15798186) Cazalla D. … Caceres J.F. (Mol. Cell. Biol. 2005) 2 3 4
  2. Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia. (PMID: 19065146) Potkin S.G. … Macciardi F. (Mol. Psychiatry 2009) 2 3 49
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RSRC1 Gene

Sources for RSRC1 Gene

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