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Aliases for RSPRY1 Gene

Aliases for RSPRY1 Gene

  • Ring Finger And SPRY Domain Containing 1 2 3
  • KIAA1972 4

External Ids for RSPRY1 Gene

Summaries for RSPRY1 Gene

Entrez Gene Summary for RSPRY1 Gene

  • This gene encodes a glycoprotein that contains a RING-type zinc finger domain and an SPRY domain of unknown function. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for RSPRY1 Gene

RSPRY1 (Ring Finger And SPRY Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is RNF123.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSPRY1 Gene

Genomics for RSPRY1 Gene

Genomic Location for RSPRY1 Gene

Start:
57,186,137 bp from pter
End:
57,240,475 bp from pter
Size:
54,339 bases
Orientation:
Plus strand

Genomic View for RSPRY1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RSPRY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSPRY1 Gene

Regulatory Elements for RSPRY1 Gene

Proteins for RSPRY1 Gene

  • Protein details for RSPRY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DX4-RSPRY_HUMAN
    Recommended name:
    RING finger and SPRY domain-containing protein 1
    Protein Accession:
    Q96DX4
    Secondary Accessions:
    • Q6UX21
    • Q8ND53

    Protein attributes for RSPRY1 Gene

    Size:
    576 amino acids
    Molecular mass:
    64180 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RSPRY1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RSPRY1 Gene

Proteomics data for RSPRY1 Gene at MOPED

Post-translational modifications for RSPRY1 Gene

No data available for DME Specific Peptides for RSPRY1 Gene

Domains for RSPRY1 Gene

Gene Families for RSPRY1 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RSPRY1 Gene

UniProtKB/Swiss-Prot:

RSPRY_HUMAN
Domain:
  • Contains 1 B30.2/SPRY domain.:
    • Q96DX4
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q96DX4
genes like me logo Genes that share domains with RSPRY1: view

Function for RSPRY1 Gene

Gene Ontology (GO) - Molecular Function for RSPRY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with RSPRY1: view

miRNA for RSPRY1 Gene

miRTarBase miRNAs that target RSPRY1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RSPRY1 Gene

Localization for RSPRY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RSPRY1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RSPRY1 Gene COMPARTMENTS Subcellular localization image for RSPRY1 gene
Compartment Confidence
extracellular 3
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RSPRY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with RSPRY1: view

Pathways for RSPRY1 Gene

SuperPathways for RSPRY1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RSPRY1 Gene

None

No data available for Pathways by source for RSPRY1 Gene

Transcripts for RSPRY1 Gene

Unigene Clusters for RSPRY1 Gene

Ring finger and SPRY domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RSPRY1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a ·
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: -
SP5: - - - - - - - - - -
SP6:
SP7: - - -
SP8:
SP9: - - -
SP10: -
SP11:

ExUns: 15b ^ 16 ^ 17 ^ 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for RSPRY1 Gene

GeneLoc Exon Structure for
RSPRY1
ECgene alternative splicing isoforms for
RSPRY1

Expression for RSPRY1 Gene

mRNA expression in normal human tissues for RSPRY1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RSPRY1 Gene

SOURCE GeneReport for Unigene cluster for RSPRY1 Gene Hs.460885

genes like me logo Genes that share expressions with RSPRY1: view

Orthologs for RSPRY1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RSPRY1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RSPRY1 36
  • 99.77 (n)
  • 100 (a)
RSPRY1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RSPRY1 36
  • 93.81 (n)
  • 96.87 (a)
RSPRY1 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RSPRY1 36
  • 94.5 (n)
  • 97.22 (a)
RSPRY1 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rspry1 36
  • 92.36 (n)
  • 96.7 (a)
Rspry1 16
Rspry1 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RSPRY1 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RSPRY1 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rspry1 36
  • 92.42 (n)
  • 96.7 (a)
chicken
(Gallus gallus)
Aves RSPRY1 36
  • 80.29 (n)
  • 86.78 (a)
RSPRY1 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RSPRY1 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22817 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rspry1 36
  • 75.12 (n)
  • 81.47 (a)
Str.19431 36
zebrafish
(Danio rerio)
Actinopterygii Dr.13269 36
rspry1 36
  • 70.95 (n)
  • 78.65 (a)
rspry1 37
  • 78 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F16A11.1 36
  • 56.37 (n)
  • 52.73 (a)
F16A11.1 37
  • 38 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3775 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2646 37
  • 54 (a)
OneToOne
Species with no ortholog for RSPRY1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RSPRY1 Gene

ENSEMBL:
Gene Tree for RSPRY1 (if available)
TreeFam:
Gene Tree for RSPRY1 (if available)

Paralogs for RSPRY1 Gene

Paralogs for RSPRY1 Gene

genes like me logo Genes that share paralogs with RSPRY1: view

Variants for RSPRY1 Gene

Sequence variations from dbSNP and Humsavar for RSPRY1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs715040 -- 57,214,567(+) GATAC(G/T)TGCTT intron-variant
rs918711 -- 57,213,664(-) AGAGT(C/G)CAAAC intron-variant
rs950003 -- 57,220,475(+) TGCTA(C/T)TGATT intron-variant
rs958148 -- 57,223,049(-) GAAGA(A/G)TGTTT intron-variant
rs2288006 -- 57,230,957(-) TAGGT(A/C)TGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RSPRY1 Gene

Variant ID Type Subtype PubMed ID
esv2714524 CNV Deletion 23290073
esv2714525 CNV Deletion 23290073

Relevant External Links for RSPRY1 Gene

HapMap Linkage Disequilibrium report
RSPRY1

Disorders for RSPRY1 Gene

No disorders were found for RSPRY1 Gene.

No data available for UniProtKB/Swiss-Prot for RSPRY1 Gene

Publications for RSPRY1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for RSPRY1 Gene

Sources for RSPRY1 Gene

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