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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RSPO4 Gene

protein-coding GIFtS: 49
GCID: GC20M000890

R-spondin 4

(Previous names: chromosome 20 open reading frame 182, R-spondin family,...)
(Previous symbol: C20orf182)

Explore 7 diseases affiliated with
RSPO4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
R-Spondin 4¹ ²		CRISTIN4² ⁵
C20orf182¹ ² ³		Chromosome 20 Open Reading Frame 182¹
R-Spondin Family, Member 4¹ ²		DJ824F16.3¹
Roof Plate-Specific Spondin-4² ³		R-Spondin-4¹
HRspo4¹

External Ids:	HGNC: 16175¹	Entrez Gene: 343637²	Ensembl: ENSG00000101282⁷	OMIM: 610573⁵	UniProtKB: Q2I0M5³

Export aliases for RSPO4 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RSPO4:

This gene encodes a member of the R-spondin family of proteins that share a common domain organization consisting of a

signal peptide, cysteine-rich/furin-like domain, thrombospondin domain and a C-terminal basic region. The encoded

protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated

with anonychia congenital. Alternate splicing results in multiple transcript variants.(provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: RSPO4_HUMAN, Q2I0M5

Function: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the

canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an

inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011387.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RSPO4 gene promoter:
SRF RP58 SRF (504 AA) FOXD1 HEN1 SRY FOXC1 IRF-7A En-1 Ik-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RSPO4 promoter sequence

Search SABiosciences Chromatin IP Primers for RSPO4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RSPO4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13

RSPO4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RSPO4 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M000890: view genomic region (about GC identifiers)

Start:	939,095 bp from pter	End:	982,907 bp from pter
Size:	43,813 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RSPO4_HUMAN, Q2I0M5 (See protein sequence)

Recommended Name: R-spondin-4 precursor

Size: 234 amino acids; 26171 Da

Subunit: Binds heparin (By similarity)

Subcellular location: Secreted (By similarity)

Miscellaneous: Upon injection into mice, it induces rapid onset of crypt cell proliferation involving beta-catenin

stabilization. It also displays efficacy in a model of chemotherapy-induced intestinal mucositis

Secondary accessions: A2A2I6 Q9UGB2

Alternative splicing: 2 isoforms: Q2I0M5-1 Q2I0M5-2

Explore the universe of human proteins at neXtProt for RSPO4: NX_Q2I0M5

Post-translational modifications:

Tyr-112 may be phosphorylated; however as this position is probably extracellular, the vivo relevance is not proven¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q2I0M5

RSPO4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001025042.2 NP_001035096.1

ENSEMBL proteins:

ENSP00000217260 ENSP00000383475

Human Recombinant Protein Products for RSPO4:

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	Uscn Proteins for RSPO4

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

RSPO4 for ontologies About GeneDecksing

RSPO4 Antibody Products:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RSPO4 for domains About GeneDecksing

3 InterPro domains/families:

IPR000884 Thrombospondin_1_rpt

IPR006212 Furin_repeat

IPR009030 Growth_fac_rcpt

Graphical View of Domain Structure for InterPro Entry Q2I0M5

ProtoNet protein and cluster: Q2I0M5

1 Blocks protein family: IPB006212 Furin-like repeat

UniProtKB/Swiss-Prot: RSPO4_HUMAN, Q2I0M5

Domain: The FU repeat is required for activation and stabilization of beta-catenin (By similarity)

Similarity: Belongs to the R-spondin family

Similarity: Contains 1 FU (furin-like) repeat

Similarity: Contains 1 TSP type-1 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RSPO4_HUMAN, Q2I0M5

Function: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the

canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an

inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (By similarity)

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008201	heparin binding	IEA	--

RSPO4 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RSPO4

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		hsa-miR-34c-5p hsa-miR-449b hsa-miR-449a hsa-miR-211 hsa-miR-877* hsa-miR-34a hsa-miR-2355-5p hsa-miR-204

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSPO4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Wnt Signaling Pathway

Wnt Signaling Pathway

0.33

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for RSPO4

Wnt Signaling Pathway

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RSPO4

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016055	Wnt receptor signaling pathway	IEA	--

RSPO4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RSPO4
Search CenterWatch for drugs/clinical trials and news about RSPO4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RSPO4 gene (2 alternative transcripts):

NM_001029871.3 NM_001040007.2

Unigene Cluster for RSPO4:

R-spondin 4

Hs.444980 [show with all ESTs]

Unigene Representative Sequence: NM_001029871

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000217260(uc002wej.3 uc002wek.3) ENST00000400634

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RSPO4
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate RSPO4 (see all 15):
		hsa-miR-34c-5p hsa-miR-449b hsa-miR-449a hsa-miR-211 hsa-miR-877* hsa-miR-34a hsa-miR-2355-5p hsa-miR-204

		SwitchGear 3'UTR luciferase reporter plasmid: RSPO4 3' UTR sequence

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Additional cDNA sequence:

AK122609.1 DQ355152.1

3 DOTS entries:

DT.97839035 DT.120838686 DT.120838681

21 AceView cDNA sequences:

BM673289 BQ017185 BQ185331 BM717748 AA416863 AI811035 BU508182 BQ636829

AA873081 AA417143 BM681374 BM674941 AK122609 BM682068 BM996047 BM729141

BQ188163 AA992432 AA813185 BM706460 BM728200

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RSPO4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGGGAAACA

About this image

RSPO4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RSPO4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RSPO4

SOURCE GeneReport for Unigene cluster: Hs.444980

SABiosciences Custom PCR Arrays for RSPO4

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for RSPO4 gene from 3/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RSPO4¹	R-spondin 4	69.37(n) 62.44(a)		428155 XM_425713.3 XP_425713.3
lizard (Anolis carolinensis)	Reptilia	RSPO4⁶	--	57(a)	1 ↔ 1	GL343346.1(493482-497493)
zebrafish (Danio rerio)	Actinopterygii	LOC570865¹	r-spondin-2-like	59.83(n) 54.04(a)		570865 XM_694390.2 XP_699482.2

ENSEMBL Gene Tree for RSPO4 (if available)
TreeFam Gene Tree for RSPO4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RSPO4 gene

RSPO3² RSPO1² RSPO2²

3 SIMAP similar genes for RSPO4 using alignment to 1 protein entry: RSPO4_HUMAN:

RSPO2 RSPO3 RSPO1

RSPO4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74315421^1,2	C	pathogenic	900167(-)	`TCCGGC/TGCAAG`	4	R C	mis¹		0	--	--	--	--
rs74315423^1,2	C	pathogenic	900903(-)	`CGACTA/GTCCCC`	4	Y C	mis¹		0	--	--	--	--
rs74315420^1,2	C	pathogenic	900927(-)	`CCGCCA/GGTACG`	4	Q R	mis¹		0	--	--	--	--
rs477982^1,2	C,F,A,H	--	891167(+)	`GGTGTC/TACCCT`	2	--	ds500¹		10		NS EA WA NA	1062
rs111813260^1,2		--	891227(+)	`AGGGCG/CCCTCC`	2	--	ds500¹		1		CSA	2
rs484390^1,2	F,H	--	891250(+)	`TCCCCC/GCAAGC`	2	--	ds500¹		5		NS EA NA	530
rs486347^1,2	C,F,A,H	--	891473(+)	`AACGGA/GGCATT`	2	--	ut3¹		16		MN NS EA NA CSA WA	2065
rs80086411^1,2	F	--	891568(+)	`AGCAGG/AGAAGT`	2	--	ut3¹		1		WA	118
rs944116^1,2	C,F,H	--	891828(+)	`AGTCAC/TGGCAA`	2	--	ut3¹		14		MN NS EA NA WA	2070
rs944117^1,2	C,F,H	--	891905(+)	`ATAGGC/TAGTGA`	2	--	ut3¹ ese³		5		NS EA NA	536

HapMap Linkage Disequilibrium report for RSPO4 (939095 - 982907 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RSPO4: --
Human Gene Mutation Database (HGMD): RSPO4

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RSPO4

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RSPO4 for disorders           About GeneDecksing

OMIM gene information: 610573
OMIM disorders: 206800
UniProtKB/Swiss-Prot: RSPO4_HUMAN, Q2I0M5

Defects in RSPO4 are the cause of nail disorder non-syndromic congenital type 4 (NDNC4) [MIM:206800]. A nail

disorder characterized by congenital anonychia or its milder phenotypic variant hyponychia. Anonychia/hyponychia is

the absence or severe hypoplasia of all fingernails and toenails without significant bone anomalies

7 diseases for RSPO4: About MalaCards

nail-patella syndrome anonychia congenita palmoplantar keratosis nail disease

keratosis esophageal cancer esophagitis

2 diseases from the University of Copenhagen DISEASES database for RSPO4:

Nail disease nail-patella syndrome

Export disorders for RSPO4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RSPO4 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with RSPO4)

Utopia: connect your pdf to the dynamic
world of online information

R-spondin proteins: a novel link to beta-catenin activation. (PubMed id 16357527)^{1, 2} Kim K.-A.... Funk W.D. (2006)
The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia. (PubMed id 17041604)^{1, 2} Blaydon D.C.... Kelsell D.P. (2006)
Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)^{1, 2} Brill L.M....Peters E.C. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
RSPO4 is the major gene in autosomal-recessive anonychia and mutations cluster in the furin-like cysteine-rich domains of the Wnt signaling ligand R-spondin 4. (PubMed id 17914448)^{1, 9} Bruchle N.O....Bergmann C. (2008)
Mutations in the gene encoding the Wnt-signaling component R-spondin 4 (RSPO4) cause autosomal recessive anonychia. (PubMed id 17186469)^{1, 9} Bergmann C....Zerres K. (2006)
A novel missense mutation in RSPO4 gene underlies autosomal recessive congenital anonychia in a consanguineous Pakistani family. (PubMed id 18070203)¹ Chishti M.S....Ahmad W. (2008)
Mutations in R-spondin 4 (RSPO4) underlie inherited anonychia. (PubMed id 17805348)¹ Ishii Y....Christiano A.M. (2008)
Congenital hyponychia without RSPO4 mutation. (PubMed id 18779895)¹ Nakamura M. and Miyachi Y. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 343637	HGNC: 16175	AceView: LOC343637	Ensembl:ENSG00000101282	euGenes: HUgn343637
ECgene: RSPO4	H-InvDB: RSPO4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RSPO4	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/RSPO4

Intellectual Property for RSPO4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RSPO4 gene:
Search GeneIP for patents involving RSPO4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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RSPO4 Gene

R-spondin 4

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RSPO4 Gene

R-spondin 4

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Genomic Viewsfor RSPO4 gene

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Protein Domains /Familiesfor RSPO4 gene

Functionfor RSPO4 gene

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External Searches for RSPO4 gene

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Specialized Databases showing RSPO4 gene

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for RSPO4 gene

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Families
for RSPO4 gene

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for RSPO4 gene

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for RSPO4 gene

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for RSPO4 gene

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for RSPO4 gene

Expression
for RSPO4 gene

Orthologs
for RSPO4 gene

Paralogs
for RSPO4 gene

Genomic Variants
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Disorders / Diseases
for RSPO4 gene

Publications
for RSPO4 gene

Intellectual Property
for RSPO4 gene

Products
for RSPO4 gene