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RSPO3 Gene

protein-coding   GIFtS: 53
GCID: GC06P127482

R-Spondin 3

(Previous names: thrombospondin, type I, domain containing 2, R-spondin 3...)
(Previous symbol: THSD2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
R-Spondin 31 2     CRISTIN12 5
THSD21 2 3     R-Spondin 3 Homolog (Xenopus Laevis)1
PWTSR2 3 5     R-spondin-32
Thrombospondin, Type I, Domain Containing 21 2     R-Spondin 3 Homolog2
Protein With TSP Type-1 Repeat2 3     hPWTSR3
Roof Plate-Specific Spondin-32 3     hRspo33
Thrombospondin Type-1 Domain-Containing Protein 22 3     

External Ids:    HGNC: 208661   Entrez Gene: 848702   Ensembl: ENSG000001463747   OMIM: 6105745   UniProtKB: Q9BXY43   

Export aliases for RSPO3 gene to outside databases

Previous GC identifer: GC06P125016


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RSPO3 Gene:
This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt
(wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways,
which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest
a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor
development. (provided by RefSeq, Jul 2013)

GeneCards Summary for RSPO3 Gene:
RSPO3 (R-spondin 3) is a protein-coding gene. Diseases associated with RSPO3 include childhood leukemia, and cleft lip. GO annotations related to this gene include frizzled binding and receptor binding. An important paralog of this gene is RSPO1.

UniProtKB/Swiss-Prot: RSPO3_HUMAN, Q9BXY4
Function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon
binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are
activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression
of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling
by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for
frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway

Gene Wiki entry for RSPO3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RSPO3 gene promoter:
         Oct-B1   E2F-4   E2F-3a   E2F-5   oct-B3   oct-B2   E2F-2   Egr-2   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RSPO3 promoter sequence
   Search Chromatin IP Primers for RSPO3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RSPO3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.33   Ensembl cytogenetic band:  6q22.33   HGNC cytogenetic band: 6q22.33

RSPO3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RSPO3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P127482:  view genomic region     (about GC identifiers)

Start:
127,439,749 bp from pter      End:
127,518,910 bp from pter
Size:
79,162 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RSPO3_HUMAN, Q9BXY4 (See protein sequence)
Recommended Name: R-spondin-3 precursor  
Size: 272 amino acids; 30929 Da
Subunit: Interacts with the extracellular domain of FZD8 and LRP6. It however does not form a ternary complex with
FZD8 and LRP6. Interacts with WNT1. Binds heparin (By similarity). Interacts with LGR4, LGR5 and LGR6
Miscellaneous: Upon injection into mice, it induces rapid onset of crypt cell proliferation involving beta-catenin
stabilization. It also displays efficacy in a model of chemotherapy-induced intestinal mucositis
(PubMed:16357527)
Secondary accessions: B2RC27 Q5VTV4 Q96K87
Alternative splicing: 2 isoforms:  Q9BXY4-1   Q9BXY4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RSPO3: NX_Q9BXY4

Explore proteomics data for RSPO3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn36
  • Modification sites at PhosphoSitePlus

  • See RSPO3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116173.2  
    ENSEMBL proteins: 
     ENSP00000349131   ENSP00000357300  
    Reactome Protein details: Q9BXY4

    RSPO3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for RSPO3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    4 InterPro protein domains:
     IPR000884 Thrombospondin_1_rpt
     IPR006212 Furin_repeat
     IPR000742 EG-like_dom
     IPR009030 Growth_fac_rcpt_N_dom

    Graphical View of Domain Structure for InterPro Entry Q9BXY4

    ProtoNet protein and cluster: Q9BXY4

    2 Blocks protein domains:
    IPB006210 Type I EGF
    IPB006212 Furin-like repeat


    UniProtKB/Swiss-Prot: RSPO3_HUMAN, Q9BXY4
    Domain: The FU repeats are required for activation and stabilization of beta-catenin (By similarity)
    Similarity: Belongs to the R-spondin family
    Similarity: Contains 2 FU (furin-like) repeats
    Similarity: Contains 1 TSP type-1 domain


    RSPO3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RSPO3_HUMAN, Q9BXY4
    Function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon
    binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are
    activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression
    of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling
    by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for
    frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI--
    GO:0005109frizzled binding IEA--
    GO:0008201heparin binding IEA--
         
    RSPO3 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rspo3):
     behavior/neurological  cardiovascular system  embryogenesis  growth/size/body  limbs/digits/tail 
     mortality/aging  normal  respiratory system  skeleton 

    RSPO3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rspo3tm1.2Jcob for RSPO3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RSPO3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RSPO3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RSPO3

    miRNA
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    miRTarBase miRNAs that target RSPO3:
    hsa-mir-335-5p (MIRT017040)

    Block miRNA regulation of human, mouse, rat RSPO3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RSPO3 (see all 14):
    hsa-miR-206 hsa-miR-188-5p hsa-miR-409-3p hsa-miR-15a hsa-miR-1 hsa-miR-497 hsa-miR-103a hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidRSPO3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RSPO3

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    GenScript: all cDNA clones in your preferred vector: RSPO3 (NM_032784)
    Sino Biological Human cDNA Clone for RSPO3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RSPO3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSPO3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSPO3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RSPO3_HUMAN, Q9BXY4: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    RSPO3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RSPO3 About    
    See pathways by source

    SuperPathContained pathways About
    1Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53
    2Wnt signaling pathway (KEGG)
    Wnt Signaling Pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for RSPO3
        Wnt Signaling Pathways


    2 Sino Biological Pathways for RSPO3
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    1 Reactome Pathway for RSPO3
        regulation of FZD by ubiquitination



    RSPO3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RSPO3
    Interactions:

        Search GeneGlobe Interaction Network for RSPO3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for RSPO3 (Q9BXY42 ENSP000003491314) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEA1Q150752MINT-8297588
    WNT11ENSP000003255264STRING: ENSP00000325526
    DMXL1ENSP000003096904STRING: ENSP00000309690
    DMXL2ENSP000002510764STRING: ENSP00000251076
    HSPBP1ENSP000002556314STRING: ENSP00000255631
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0060070canonical Wnt signaling pathway IEA--
    GO:0060670branching involved in labyrinthine layer morphogenesis IEA--

    RSPO3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RSPO3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RSPO3 gene: 
    NM_032784.4  

    Unigene Cluster for RSPO3:

    R-spondin 3
    Hs.135254  [show with all ESTs]
    Unigene Representative Sequence: AF251057
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356698(uc003qar.3) ENST00000368317(uc003qas.1) ENST00000485757

    miRNA
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    Block miRNA regulation of human, mouse, rat RSPO3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RSPO3 (see all 14):
    hsa-miR-206 hsa-miR-188-5p hsa-miR-409-3p hsa-miR-15a hsa-miR-1 hsa-miR-497 hsa-miR-103a hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidRSPO3 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RSPO3
      QuantiTect SYBR Green Assays in human, mouse, rat RSPO3
      QuantiFast Probe-based Assays in human, mouse, rat RSPO3

    Additional mRNA sequence: 

    AF086298.1 AF251057.1 AK314912.1 BC022367.1 

    6 DOTS entries:

    DT.111264  DT.95265955  DT.91677614  DT.75135401  DT.100020221  DT.97834792 

    Selected AceView cDNA sequences (see all 60):

    BE787360 CD634316 NM_032784 CD634311 BX112438 CR621431 BX423114 W73741 
    BX499768 AW316562 CB157068 BC022367 AI744816 AF251057 N73406 AF086298 
    AA582362 AI685566 AW073421 CB051656 BF589322 AA709141 AA568446 AA478875 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RSPO3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTTCTTT
    RSPO3 Expression
    About this image


    RSPO3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Epithalamus
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Cells Ureteric Bud
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Prosencephalon
    RSPO3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RSPO3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.135254

    UniProtKB/Swiss-Prot: RSPO3_HUMAN, Q9BXY4
    Tissue specificity: Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus
    and lymph node

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RSPO3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rspo31 , 5 R-spondin 3 homolog (Xenopus laevis)1, 5 88.85(n)1
    87.13(a)1
      10 (16.64 cM)5
    727801  NM_028351.31  NP_082627.31 
     294531095 
    chicken
    (Gallus gallus)
    Aves RSPO31 R-spondin 3 80.53(n)
    80.8(a)
      421715  XM_419752.4  XP_419752.1 
    lizard
    (Anolis carolinensis)
    Reptilia RSPO36
    R-spondin 3
    63(a)
    1 ↔ 1
    GL343681.1(88514-164820)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.184172 Transcribed sequence with weak similarity to protein more 77.17(n)    AL972847.2 
    zebrafish
    (Danio rerio)
    Actinopterygii rspo31 R-spondin 3 homolog (Xenopus laevis) 61.81(n)
    58.25(a)
      100007702  NM_001017358.1  NP_001017358.1 


    ENSEMBL Gene Tree for RSPO3 (if available)
    TreeFam Gene Tree for RSPO3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RSPO3 gene
    RSPO12  RSPO42  RSPO22  
    3 SIMAP similar genes for RSPO3 using alignment to 1 protein entry:     RSPO3_HUMAN:
    RSPO2    RSPO1    RSPO4

    RSPO3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RSPO3 (see all 1271)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1384279481,2
    --127438132(+) GGAGAG/TAGAAG 1 -- us2k10--------
    rs737731921,2
    C,F--127438402(+) TTCATC/TGGCTG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1910780131,2
    --127438437(+) AAGCTA/CACCAT 1 -- us2k10--------
    rs1416121491,2
    C--127438564(+) AAGAT-/AAGAAAGT 1 -- us2k10--------
    rs108723111,2
    C,F,A,H--127438642(+) AGATGC/AGAGAT 1 -- us2k122Minor allele frequency- A:0.37NS EA NA WA CSA 2354
    rs1821767751,2
    --127438831(+) GTCCTA/GAGCGC 1 -- us2k10--------
    rs1432621001,2
    --127438835(+) TGAGCG/TCACAC 1 -- us2k10--------
    rs784137771,2
    C,F--127438857(+) CTCCCC/AGCTCG 1 -- us2k11Minor allele frequency- A:0.13WA 118
    rs1389838401,2
    C--127438963(+) GAAAG-/GAAA  
            
    GAAAG
    1 -- us2k10--------
    rs283725991,2
    --127439025(+) AGGAAG/AGAAAG 1 -- us2k1 trp31Minor allele frequency- A:0.00NA 2

    HapMap Linkage Disequilibrium report for RSPO3 (127439749 - 127518910 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RSPO3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RSPO3
    DNA2.0 Custom Variant and Variant Library Synthesis for RSPO3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610574    OMIM disorders: --

    7 diseases for RSPO3:    
    About MalaCards
    childhood leukemia    cleft lip    coronary heart disease    inflammatory bowel disease
    leukemia    cerebritis    neuronitis


    RSPO3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RSPO3
    Human Genome Epidemiology (HuGE) Navigator: RSPO3 (4 documents)

    Export disorders for RSPO3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RSPO3 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with RSPO3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. (PubMed id 21909109)1, 4 Kim Y.J....Cho Y.S. (Nat. Genet. 2011)
    2. LGR4 and LGR5 are R-spondin receptors mediating Wnt/beta-catenin and Wnt/PCP signalling. (PubMed id 21909076)1, 2 Glinka A.... Niehrs C. (EMBO Rep. 2011)
    3. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. (PubMed id 20935629)1, 4 Heid I.M....Lindgren C.M. (Nat. Genet. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. (PubMed id 19084217)1, 4 Benyamin B....Visscher P.M. (Am. J. Hum. Genet. 2009)
    6. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (Genet. Med. 2008)
    7. R-spondin proteins: a novel link to beta-catenin activation. (PubMed id 16357527)1, 2 Kim K.-A.... Funk W.D. (Cell Cycle 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84870 HGNC: 20866 AceView: THSD2 Ensembl:ENSG00000146374 euGenes: HUgn84870
    ECgene: RSPO3 H-InvDB: RSPO3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RSPO3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RSPO3 gene:
    Search GeneIP for patents involving RSPO3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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