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Aliases for RSPO3 Gene

Aliases for RSPO3 Gene

  • R-Spondin 3 2 3 5
  • Thrombospondin Type-1 Domain-Containing Protein 2 3 4
  • Thrombospondin, Type I, Domain Containing 2 2 3
  • Protein With TSP Type-1 Repeat 3 4
  • Roof Plate-Specific Spondin-3 3 4
  • THSD2 3 4
  • PWTSR 3 4
  • R-Spondin 3 Homolog (Xenopus Laevis) 2
  • R-Spondin 3 Homolog 3
  • R-Spondin-3 3
  • CRISTIN1 3
  • HPWTSR 4
  • HRspo3 4

External Ids for RSPO3 Gene

Previous HGNC Symbols for RSPO3 Gene

  • THSD2

Previous GeneCards Identifiers for RSPO3 Gene

  • GC06P127482
  • GC06P125016

Summaries for RSPO3 Gene

Entrez Gene Summary for RSPO3 Gene

  • This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013]

GeneCards Summary for RSPO3 Gene

RSPO3 (R-Spondin 3) is a Protein Coding gene. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling and mTOR signaling pathway (KEGG). GO annotations related to this gene include receptor binding and G-protein coupled receptor binding. An important paralog of this gene is RSPO2.

UniProtKB/Swiss-Prot for RSPO3 Gene

  • Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity).

Gene Wiki entry for RSPO3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSPO3 Gene

Genomics for RSPO3 Gene

Regulatory Elements for RSPO3 Gene

Enhancers for RSPO3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F127160 0.3 FANTOM5 13.8 +42.1 42132 0.4 PKNOX1 ZNF7 ZEB1 ZNF366 PRDM10 ZNF600 FOS RFX1 ZFP37 ZEB2 RSPO3 SOGA3 RNF146 LOC105377989
GH06F127146 1.1 Ensembl ENCODE 11 +28.6 28564 0.7 PKNOX1 CTBP1 JUN MYC ZBTB20 ETS1 TRIM28 RSPO3 LOC105377989 RNF146
GH06F127052 0.4 ENCODE 10.6 -64.8 -64815 2.1 JUND ZNF133 JUN EP300 RSPO3 LOC105377991
GH06F127051 0.2 ENCODE 10.6 -66.6 -66568 1.3 JUND RSPO3 LOC105377991
GH06F126812 0.2 Ensembl 9.9 -306.3 -306304 0.2 RSPO3 PIR31351 LOC105377992
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RSPO3 on UCSC Golden Path with GeneCards custom track

Promoters for RSPO3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001226472 197 2400 CTCF SUZ12 SIN3A ZBTB48 ZNF366 POLR2A SCRT2 ZNF600 MAFK ZBTB20

Genomic Location for RSPO3 Gene

Chromosome:
6
Start:
127,118,604 bp from pter
End:
127,199,481 bp from pter
Size:
80,878 bases
Orientation:
Plus strand

Genomic View for RSPO3 Gene

Genes around RSPO3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RSPO3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RSPO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSPO3 Gene

Proteins for RSPO3 Gene

  • Protein details for RSPO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXY4-RSPO3_HUMAN
    Recommended name:
    R-spondin-3
    Protein Accession:
    Q9BXY4
    Secondary Accessions:
    • B2RC27
    • Q5VTV4
    • Q96K87

    Protein attributes for RSPO3 Gene

    Size:
    272 amino acids
    Molecular mass:
    30929 Da
    Quaternary structure:
    • Interacts with the extracellular domain of FZD8 and LRP6 (By similarity). It however does not form a ternary complex with FZD8 and LRP6 (By similarity). Interacts with WNT1 (By similarity). Binds heparin. Interacts with LGR4, LGR5 and LGR6 (PubMed:21727895, PubMed:21909076, PubMed:22615920).
    Miscellaneous:
    • Upon injection into mice, it induces rapid onset of crypt cell proliferation involving beta-catenin stabilization. It also displays efficacy in a model of chemotherapy-induced intestinal mucositis (PubMed:16357527).

    Alternative splice isoforms for RSPO3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RSPO3 Gene

Post-translational modifications for RSPO3 Gene

  • Glycosylation at Asn 36
  • Modification sites at PhosphoSitePlus

Other Protein References for RSPO3 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for RSPO3

No data available for DME Specific Peptides for RSPO3 Gene

Domains & Families for RSPO3 Gene

Gene Families for RSPO3 Gene

Protein Domains for RSPO3 Gene

Suggested Antigen Peptide Sequences for RSPO3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXY4

UniProtKB/Swiss-Prot:

RSPO3_HUMAN :
  • The FU repeats are required for activation and stabilization of beta-catenin.
  • Belongs to the R-spondin family.
  • Contains 2 FU (furin-like) repeats.
Domain:
  • The FU repeats are required for activation and stabilization of beta-catenin.
  • Contains 1 TSP type-1 domain.
Family:
  • Belongs to the R-spondin family.
Similarity:
  • Contains 2 FU (furin-like) repeats.
genes like me logo Genes that share domains with RSPO3: view

Function for RSPO3 Gene

Molecular function for RSPO3 Gene

UniProtKB/Swiss-Prot Function:
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity).

Gene Ontology (GO) - Molecular Function for RSPO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 22615920
GO:0005109 frizzled binding IEA --
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with RSPO3: view
genes like me logo Genes that share phenotypes with RSPO3: view

Animal Models for RSPO3 Gene

MGI Knock Outs for RSPO3:

Animal Model Products

  • Taconic Biosciences Mouse Models for RSPO3

miRNA for RSPO3 Gene

miRTarBase miRNAs that target RSPO3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RSPO3 Gene

Localization for RSPO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RSPO3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RSPO3 Gene COMPARTMENTS Subcellular localization image for RSPO3 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for RSPO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with RSPO3: view

Pathways & Interactions for RSPO3 Gene

genes like me logo Genes that share pathways with RSPO3: view

SIGNOR curated interactions for RSPO3 Gene

Activates:

Gene Ontology (GO) - Biological Process for RSPO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001974 blood vessel remodeling ISS --
GO:0002040 sprouting angiogenesis ISS --
GO:0016055 Wnt signaling pathway IEA --
GO:0030177 positive regulation of Wnt signaling pathway NAS 24431302
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with RSPO3: view

Transcripts for RSPO3 Gene

Unigene Clusters for RSPO3 Gene

R-spondin 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RSPO3 Gene

No ASD Table

Relevant External Links for RSPO3 Gene

GeneLoc Exon Structure for
RSPO3
ECgene alternative splicing isoforms for
RSPO3

Expression for RSPO3 Gene

mRNA expression in normal human tissues for RSPO3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RSPO3 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x7.9), Esophagus - Muscularis (x6.4), and Uterus (x5.3).

NURSA nuclear receptor signaling pathways regulating expression of RSPO3 Gene:

RSPO3

SOURCE GeneReport for Unigene cluster for RSPO3 Gene:

Hs.135254

mRNA Expression by UniProt/SwissProt for RSPO3 Gene:

Q9BXY4-RSPO3_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and lymph node (PubMed:12463421). Highly expressed in endothelial cells (PubMed:26766444).
genes like me logo Genes that share expression patterns with RSPO3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for RSPO3 Gene

Orthologs for RSPO3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RSPO3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RSPO3 34 35
  • 99.51 (n)
cow
(Bos Taurus)
Mammalia RSPO3 34 35
  • 92.03 (n)
mouse
(Mus musculus)
Mammalia Rspo3 34 16 35
  • 88.85 (n)
rat
(Rattus norvegicus)
Mammalia Rspo3 34
  • 88.36 (n)
oppossum
(Monodelphis domestica)
Mammalia RSPO3 35
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RSPO3 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RSPO3 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves RSPO3 34 35
  • 80.53 (n)
lizard
(Anolis carolinensis)
Reptilia RSPO3 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rspo3 34
  • 77.51 (n)
Str.18417 34
zebrafish
(Danio rerio)
Actinopterygii rspo3 34 35
  • 61.81 (n)
Species where no ortholog for RSPO3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RSPO3 Gene

ENSEMBL:
Gene Tree for RSPO3 (if available)
TreeFam:
Gene Tree for RSPO3 (if available)

Paralogs for RSPO3 Gene

Paralogs for RSPO3 Gene

(3) SIMAP similar genes for RSPO3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RSPO3: view

Variants for RSPO3 Gene

Sequence variations from dbSNP and Humsavar for RSPO3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10457487 -- 127,198,089(+) CTACA(A/C)CTGCA intron-variant, utr-variant-3-prime
rs10872311 -- 127,117,497(+) AGATG(A/C)GAGAT intron-variant, upstream-variant-2KB
rs111330497 -- 127,129,777(+) CATAG(A/G)GAACT intron-variant
rs111421394 -- 127,191,423(+) ATCTC(C/T)AAGGG intron-variant
rs111444332 -- 127,195,816(+) CTTTC(A/C/G/T)TTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RSPO3 Gene

Variant ID Type Subtype PubMed ID
nsv472486 CNV novel sequence insertion 20440878

Variation tolerance for RSPO3 Gene

Residual Variation Intolerance Score: 40.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RSPO3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RSPO3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSPO3 Gene

Disorders for RSPO3 Gene

Relevant External Links for RSPO3

Genetic Association Database (GAD)
RSPO3
Human Genome Epidemiology (HuGE) Navigator
RSPO3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RSPO3

No disorders were found for RSPO3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RSPO3 Gene

Publications for RSPO3 Gene

  1. LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor. (PMID: 22615920) Gong X. … Liu Q. (PLoS ONE 2012) 3 4 64
  2. LGR4 and LGR5 are R-spondin receptors mediating Wnt/beta-catenin and Wnt/PCP signalling. (PMID: 21909076) Glinka A. … Niehrs C. (EMBO Rep. 2011) 3 4 64
  3. Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. (PMID: 21909109) Kim Y.J. … Cho Y.S. (Nat. Genet. 2011) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. (PMID: 20935629) Heid I.M. … Lindgren C.M. (Nat. Genet. 2010) 3 46 64

Products for RSPO3 Gene

Sources for RSPO3 Gene

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