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Aliases for RSPO3 Gene

Aliases for RSPO3 Gene

  • R-Spondin 3 2 3
  • PWTSR 3 4 6
  • Thrombospondin Type-1 Domain-Containing Protein 2 3 4
  • Thrombospondin, Type I, Domain Containing 2 2 3
  • Protein With TSP Type-1 Repeat 3 4
  • Roof Plate-Specific Spondin-3 3 4
  • CRISTIN1 3 6
  • THSD2 3 4
  • R-Spondin 3 Homolog (Xenopus Laevis) 2
  • R-Spondin 3 Homolog 3
  • R-Spondin-3 3
  • HPWTSR 4
  • HRspo3 4

External Ids for RSPO3 Gene

Previous HGNC Symbols for RSPO3 Gene

  • THSD2

Previous GeneCards Identifiers for RSPO3 Gene

  • GC06P127482
  • GC06P125016

Summaries for RSPO3 Gene

Entrez Gene Summary for RSPO3 Gene

  • This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013]

GeneCards Summary for RSPO3 Gene

RSPO3 (R-Spondin 3) is a Protein Coding gene. Among its related pathways are Wnt signaling pathway (KEGG) and Non-Canonical Wnt Pathway. GO annotations related to this gene include receptor binding and frizzled binding. An important paralog of this gene is RSPO2.

UniProtKB/Swiss-Prot for RSPO3 Gene

  • Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway.

Gene Wiki entry for RSPO3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSPO3 Gene

Genomics for RSPO3 Gene

Regulatory Elements for RSPO3 Gene

Genomic Location for RSPO3 Gene

Start:
127,118,604 bp from pter
End:
127,199,481 bp from pter
Size:
80,878 bases
Orientation:
Plus strand

Genomic View for RSPO3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RSPO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSPO3 Gene

Proteins for RSPO3 Gene

  • Protein details for RSPO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXY4-RSPO3_HUMAN
    Recommended name:
    R-spondin-3
    Protein Accession:
    Q9BXY4
    Secondary Accessions:
    • B2RC27
    • Q5VTV4
    • Q96K87

    Protein attributes for RSPO3 Gene

    Size:
    272 amino acids
    Molecular mass:
    30929 Da
    Quaternary structure:
    • Interacts with the extracellular domain of FZD8 and LRP6. It however does not form a ternary complex with FZD8 and LRP6. Interacts with WNT1. Binds heparin (By similarity). Interacts with LGR4, LGR5 and LGR6.
    Miscellaneous:
    • Upon injection into mice, it induces rapid onset of crypt cell proliferation involving beta-catenin stabilization. It also displays efficacy in a model of chemotherapy-induced intestinal mucositis (PubMed:16357527).

    Alternative splice isoforms for RSPO3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RSPO3 Gene

Proteomics data for RSPO3 Gene at MOPED

Post-translational modifications for RSPO3 Gene

  • Glycosylation at Asn36
  • Modification sites at PhosphoSitePlus

Other Protein References for RSPO3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RSPO3 Gene

Domains for RSPO3 Gene

Gene Families for RSPO3 Gene

HGNC:

Protein Domains for RSPO3 Gene

Suggested Antigen Peptide Sequences for RSPO3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXY4

UniProtKB/Swiss-Prot:

RSPO3_HUMAN :
  • Q9BXY4
Domain:
  • The FU repeats are required for activation and stabilization of beta-catenin.
  • Contains 1 TSP type-1 domain.
Family:
  • Belongs to the R-spondin family.
Similarity:
  • Contains 2 FU (furin-like) repeats.
genes like me logo Genes that share domains with RSPO3: view

Function for RSPO3 Gene

Molecular function for RSPO3 Gene

UniProtKB/Swiss-Prot Function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway.

Gene Ontology (GO) - Molecular Function for RSPO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
GO:0005102 receptor binding IPI 22615920
GO:0005109 frizzled binding IEA --
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with RSPO3: view
genes like me logo Genes that share phenotypes with RSPO3: view

Animal Models for RSPO3 Gene

MGI Knock Outs for RSPO3:

miRNA for RSPO3 Gene

miRTarBase miRNAs that target RSPO3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RSPO3 Gene

Localization for RSPO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RSPO3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RSPO3 Gene COMPARTMENTS Subcellular localization image for RSPO3 gene
Compartment Confidence
extracellular 2

Gene Ontology (GO) - Cellular Components for RSPO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with RSPO3: view

Pathways for RSPO3 Gene

genes like me logo Genes that share pathways with RSPO3: view

Pathways by source for RSPO3 Gene

2 Sino Biological pathways for RSPO3 Gene
1 R&D Systems pathway for RSPO3 Gene

Gene Ontology (GO) - Biological Process for RSPO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060070 canonical Wnt signaling pathway IEA --
GO:0060670 branching involved in labyrinthine layer morphogenesis IEA --
GO:0090263 positive regulation of canonical Wnt signaling pathway IBA --
genes like me logo Genes that share ontologies with RSPO3: view

Transcripts for RSPO3 Gene

mRNA/cDNA for RSPO3 Gene

Unigene Clusters for RSPO3 Gene

R-spondin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RSPO3 Gene

No ASD Table

Relevant External Links for RSPO3 Gene

GeneLoc Exon Structure for
RSPO3
ECgene alternative splicing isoforms for
RSPO3

Expression for RSPO3 Gene

mRNA expression in normal human tissues for RSPO3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RSPO3 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (7.9), Esophagus - Muscularis (6.4), and Uterus (5.3).

SOURCE GeneReport for Unigene cluster for RSPO3 Gene Hs.135254

mRNA Expression by UniProt/SwissProt for RSPO3 Gene

Q9BXY4-RSPO3_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and lymph node.
genes like me logo Genes that share expressions with RSPO3: view

No data available for Protein expression for RSPO3 Gene

Orthologs for RSPO3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RSPO3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RSPO3 35
  • 99.51 (n)
  • 99.63 (a)
RSPO3 36
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RSPO3 35
  • 92.03 (n)
  • 90.81 (a)
RSPO3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RSPO3 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rspo3 35
  • 88.85 (n)
  • 87.13 (a)
Rspo3 16
Rspo3 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RSPO3 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RSPO3 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rspo3 35
  • 88.36 (n)
  • 86.76 (a)
chicken
(Gallus gallus)
Aves RSPO3 35
  • 80.53 (n)
  • 80.8 (a)
RSPO3 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RSPO3 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rspo3 35
  • 77.51 (n)
  • 76.7 (a)
Str.18417 35
zebrafish
(Danio rerio)
Actinopterygii rspo3 35
  • 61.81 (n)
  • 58.25 (a)
rspo3 36
  • 42 (a)
OneToOne
Species with no ortholog for RSPO3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RSPO3 Gene

ENSEMBL:
Gene Tree for RSPO3 (if available)
TreeFam:
Gene Tree for RSPO3 (if available)

Paralogs for RSPO3 Gene

Paralogs for RSPO3 Gene

Selected SIMAP similar genes for RSPO3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RSPO3: view

Variants for RSPO3 Gene

Sequence variations from dbSNP and Humsavar for RSPO3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs994495 -- 127,129,109(-) AAACT(A/G)TAAAA intron-variant
rs1134070 -- 127,199,384(+) AGTAT(C/T)CATAA utr-variant-3-prime
rs1474696 -- 127,128,101(-) TTTTC(C/T)AACAT intron-variant
rs1892170 -- 127,139,446(-) ACTAC(G/T)AACTT intron-variant
rs1892171 -- 127,139,204(-) ACATA(C/T)AAAAT intron-variant

Relevant External Links for RSPO3 Gene

HapMap Linkage Disequilibrium report
RSPO3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RSPO3 Gene

Disorders for RSPO3 Gene

Relevant External Links for RSPO3

Genetic Association Database (GAD)
RSPO3
Human Genome Epidemiology (HuGE) Navigator
RSPO3
genes like me logo Genes that share disorders with RSPO3: view

No data available for UniProtKB/Swiss-Prot for RSPO3 Gene

Publications for RSPO3 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. R-spondin proteins: a novel link to beta-catenin activation. (PMID: 16357527) Kim K.-A. … Funk W.D. (Cell Cycle 2006) 3 4
  5. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira A.R. … Marazita M.L. (Genet. Med. 2008) 3 48

Products for RSPO3 Gene

Sources for RSPO3 Gene

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