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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RSPO2 Gene

protein-coding   GIFtS: 53
GCID: GC08M108981

R-Spondin 2

(Previous name: R-spondin 2 homolog (Xenopus laevis))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
R-Spondin 21 2     R-spondin-22
Roof Plate-Specific Spondin-22 3     R-Spondin 2 Homolog2
CRISTIN22 5     hRspo23
R-Spondin 2 Homolog (Xenopus Laevis)1     

External Ids:    HGNC: 285831   Entrez Gene: 3404192   Ensembl: ENSG000001476557   OMIM: 6105755   UniProtKB: Q6UXX93   

Export aliases for RSPO2 gene to outside databases

Previous GC identifer: GC08M104233


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RSPO2 Gene:
R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1; MIM 116806) signaling
(Kim et al., 2006 (PubMed 16357527)).(supplied by OMIM, Mar 2008)

GeneCards Summary for RSPO2 Gene: 
RSPO2 (R-spondin 2) is a protein-coding gene. Diseases associated with RSPO2 include keloids, and osteoarthritis, and among its related super-pathways are Non-Canonical Wnt Pathway and Wnt signaling pathway. GO annotations related to this gene include heparin binding. An important paralog of this gene is RSPO3.

UniProtKB/Swiss-Prot: RSPO2_HUMAN, Q6UXX9
Function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon
binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are
activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression
of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling
by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a
ligand for frizzled and LRP receptors




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RSPO2 gene promoter:
         HFH-3   Pbx1a   NF-YA   FOXI1   NF-YB   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRSPO2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RSPO2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RSPO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q23.1   Ensembl cytogenetic band:  8q23.1   HGNC cytogenetic band: 8q23.1

RSPO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RSPO2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M108981:  view genomic region     (about GC identifiers)

Start:
108,911,544 bp from pter      End:
109,095,913 bp from pter
Size:
184,370 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RSPO2_HUMAN, Q6UXX9 (See protein sequence)
Recommended Name: R-spondin-2 precursor  
Size: 243 amino acids; 28315 Da
Subunit: Interacts with WNT1. Binds heparin (By similarity). Interacts with LGR4, LGR5 and LGR6
Subcellular location: Secreted (By similarity)
Miscellaneous: Upon injection into mice, it induces rapid onset of crypt cell proliferation involving beta-catenin
stabilization. It also displays efficacy in a model of chemotherapy-induced intestinal mucositis
(PubMed:16357527)
Secondary accessions: B3KVP0 Q4G0U4 Q8N6X6
Alternative splicing: 3 isoforms:  Q6UXX9-1   Q6UXX9-2   Q6UXX9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RSPO2: NX_Q6UXX9

Explore proteomics data for RSPO2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6UXX9

  • RSPO2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RSPO2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001269792.1  NP_848660.3  

    ENSEMBL proteins: 
     ENSP00000428940   ENSP00000427937   ENSP00000276659   ENSP00000428614   ENSP00000430485  
     ENSP00000430010   ENSP00000429159   ENSP00000430973   ENSP00000367698  

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    Sino Biological Recombinant Protein for RSPO2
    Sino Biological Cell Lysate for RSPO2 
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    Cloud-Clone Corp. Proteins for RSPO2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0009986cell surface IEA--

    RSPO2 for ontologies           About GeneDecksing



    RSPO2 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR000884 Thrombospondin_1_rpt
     IPR006212 Furin_repeat
     IPR009030 Growth_fac_rcpt_N_dom

    Graphical View of Domain Structure for InterPro Entry Q6UXX9

    ProtoNet protein and cluster: Q6UXX9

    1 Blocks protein domain: IPB006212 Furin-like repeat

    UniProtKB/Swiss-Prot: RSPO2_HUMAN, Q6UXX9
    Domain: The FU repeat is required for activation and stabilization of beta-catenin (By similarity)
    Similarity: Belongs to the R-spondin family
    Similarity: Contains 1 FU (furin-like) repeat
    Similarity: Contains 1 TSP type-1 domain


    RSPO2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RSPO2_HUMAN, Q6UXX9
    Function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon
    binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are
    activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression
    of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling
    by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a
    ligand for frizzled and LRP receptors

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI--
    GO:0008201heparin binding IEA--
         
    RSPO2 for ontologies           About GeneDecksing


    Phenotypes:
         15/16 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Rspo2) (see all 16):
     behavior/neurological  cardiovascular system  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  hearing/vestibular/ear  homeostasis/metabolism  integument  limbs/digits/tail 
     mortality/aging  no phenotypic analysis  renal/urinary system  reproductive system  respiratory system 

    RSPO2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rspo2tm1Suda for RSPO2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RSPO2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RSPO2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RSPO2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RSPO2 

    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate RSPO2 (see all 28):
    hsa-miR-181c hsa-let-7d hsa-let-7c hsa-let-7g hsa-miR-3200-3p hsa-miR-144 hsa-let-7a hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmidRSPO2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSPO2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RSPO2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53
    2Wnt signaling pathway
    Wnt Signaling Pathway0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for RSPO2
        Wnt Signaling Pathway


    2 Sino Biological Pathways for RSPO2 
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RSPO2

    1 Interacting protein for RSPO2 (Q6UXX93) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WNT11O960143I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001649osteoblast differentiation IEA--
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0030282bone mineralization IEA--
    GO:0035115embryonic forelimb morphogenesis IEA--
    GO:0035116embryonic hindlimb morphogenesis IEA--

    RSPO2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RSPO2

    Search CenterWatch for drugs/clinical trials and news about RSPO2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RSPO2 gene (2 alternative transcripts): 
    NM_001282863.1  NM_178565.4  

    Unigene Cluster for RSPO2:

    R-spondin 2
    Hs.444834  [show with all ESTs]
    Unigene Representative Sequence: NM_178565
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000517939(uc003ymq.3) ENST00000517781(uc003ymr.3) ENST00000276659(uc003yms.3)
    ENST00000521502 ENST00000521757 ENST00000521956 ENST00000520026 ENST00000522333
    ENST00000378439
    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate RSPO2 (see all 28):
    hsa-miR-181c hsa-let-7d hsa-let-7c hsa-let-7g hsa-miR-3200-3p hsa-miR-144 hsa-let-7a hsa-miR-155
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RSPO2
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    Additional mRNA sequence: 

    AK123023.1 AK123027.1 AY358166.1 BC027938.1 BC036554.1 

    4 DOTS entries:

    DT.40207933  DT.103816  DT.100674754  DT.120639542 

    24/31 AceView cDNA sequences (see all 31):

    AW160873 D38717 AI656718 BU101597 AI417538 AI379477 BQ185494 R52393 
    BC027938 AA723927 AK123023 AY358166 AK123027 NM_178565 R52392 BX478040 
    BI912396 AA974429 BQ187856 AI016251 AW161744 BI524005 AA328082 CB854676 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RSPO2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
    SP1:              -           -     -                                 
    SP2:                          -     -     -                           
    SP3:                                -                                 
    SP4:                                                                  


    ECgene alternative splicing isoforms for RSPO2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RSPO2 expression in normal human tissues (normalized intensities)      RSPO2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTATTTACA
    RSPO2 Expression
    About this image


    RSPO2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Late Floor Plate Cells Mesencephalic Floor Plate
             Mesencephalic Roof Plate
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Progress Zone Cells Limb Bud
             HyStem+BMP4-induced SM30 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Progress Zone Cells Limb Bud
             HyStem+BMP4-induced SM30 cells
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Progress Zone Cells Limb Bud
             Limb Bud
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
             Extraocular Muscles

    See RSPO2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RSPO2

    SOURCE GeneReport for Unigene cluster: Hs.444834
        SABiosciences Custom PCR Arrays for RSPO2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RSPO2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSPO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RSPO2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rspo21 , 5 R-spondin 2 homolog (Xenopus laevis)1, 5 92.32(n)1
    95.88(a)1
      15 (16.73 cM)5
    2394051  NM_172815.31  NP_766403.11 
     430208115 
    chicken
    (Gallus gallus)
    Aves RSPO21 R-spondin 2 81.11(n)
    84.76(a)
      420271  XM_418383.2  XP_418383.2 
    lizard
    (Anolis carolinensis)
    Reptilia RSPO26
    R-spondin 2
    86(a)
    1 ↔ 1
    4(11355689-11474047)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5660541 R-spondin 3-like 70.4(n)
    73.03(a)
      566054  XM_001919423.3  XP_001919458.3 


    ENSEMBL Gene Tree for RSPO2 (if available)
    TreeFam Gene Tree for RSPO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RSPO2 gene
    RSPO32  RSPO12  RSPO42  
    3 SIMAP similar genes for RSPO2 using alignment to 6 protein entries:     RSPO2_HUMAN (see all proteins):
    RSPO4    RSPO3    RSPO1

    RSPO2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RSPO2
    PGOHUM00000239732


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3698 SNPs in RSPO2 are shown (see all 3698)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1841214661,2
    --108911062(+) AATCAA/GTATTT 1 -- ds50010--------
    rs1146460691,2
    F--108911108(+) TAGGTG/AACCAA 1 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1874844531,2
    --108911143(+) ATGCCA/GTGGTG 1 -- ds50010--------
    rs1434300341,2
    C--108911506(+) TCTAAA/GTGTAT 1 -- ds50010--------
    rs343080061,2
    C--108911630(+) GGAGA-/CCCCCC 1 -- ut310--------
    rs341292281,2
    C--108911665(+) TGTAA-/ATAGAC 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs1160019151,2
    C,F--108911708(+) GTAAAC/ACCTAA 1 -- ut311Minor allele frequency- A:0.04WA 118
    rs1913166071,2
    --108911744(+) CTTATC/TATCTC 1 -- ut310--------
    rs1823714441,2
    --108911746(+) TATTAG/TCTCAT 1 -- ut310--------
    rs1132456171,2
    F--108911793(+) CTTATC/TGGTAA 1 -- ut311Minor allele frequency- T:0.00CSA 1

    HapMap Linkage Disequilibrium report for RSPO2 (108911544 - 109095913 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RSPO2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2737420CNV Deletion23290073
    esv2737421CNV Deletion23290073
    nsv528821CNV Loss19592680


    Human Gene Mutation Database (HGMD): RSPO2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RSPO2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610575    OMIM disorders: --

    3 diseases for RSPO2:    About MalaCards
    keloids    osteoarthritis    colon cancer


    RSPO2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RSPO2

    Export disorders for RSPO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RSPO2 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with RSPO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. R-spondin proteins: a novel link to beta-catenin activation. (PubMed id 16357527)1, 2 Kim K.-A.... Funk W.D. (2006)
    2. R-Spondin2 is a secreted activator of Wnt/beta-cateni n signaling and is required for Xenopus myogenesis. (PubMed id 15469841)1, 3 Kazanskaya O....Wu W. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    6. Oocyte-derived R-spondin2 promotes ovarian follicle de velopment. (PubMed id 23407710)1 Cheng Y....Hsueh A.J. (2013)
    7. Recurrent R-spondin fusions in colon cancer. (PubMed id 22895193)1 Seshagiri S....de Sauvage F.J. (2012)
    8. LGR6 is a high affinity receptor of R-spondins and pot entially functions as a tumor suppressor. (PubMed id 22615920)2 Gong X....Liu Q. (2012)
    9. The role of R-spondin2 in keratinocyte proliferation and epidermal thickening in keloid scarring. (PubMed id 21160497)1 Chua A.W....Phan T.T. (2011)
    10. LGR4 and LGR5 are R-spondin receptors mediating Wnt/beta-catenin and Wnt/PCP signalling. (PubMed id 21909076)2 Glinka A.... Niehrs C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 340419 HGNC: 28583 AceView: MGC35555 Ensembl:ENSG00000147655 euGenes: HUgn340419
    ECgene: RSPO2 H-InvDB: RSPO2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RSPO2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RSPO2 gene:
    Search GeneIP for patents involving RSPO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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