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RSPO2 Gene

protein-coding   GIFtS: 55
GCID: GC08M108981

R-Spondin 2

(Previous name: R-spondin 2 homolog (Xenopus laevis))
  Search for RSPO2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
R-Spondin 21 2     R-spondin-22
Roof Plate-Specific Spondin-22 3     R-Spondin 2 Homolog2
CRISTIN22 5     hRspo23
R-Spondin 2 Homolog (Xenopus Laevis)1     

External Ids:    HGNC: 285831   Entrez Gene: 3404192   Ensembl: ENSG000001476557   OMIM: 6105755   UniProtKB: Q6UXX93   

Export aliases for RSPO2 gene to outside databases

Previous GC identifer: GC08M104233


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RSPO2 Gene:
R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1; MIM 116806) signaling
(Kim et al., 2006 (PubMed 16357527)).(supplied by OMIM, Mar 2008)

GeneCards Summary for RSPO2 Gene:
RSPO2 (R-spondin 2) is a protein-coding gene. GO annotations related to this gene include heparin binding and receptor binding. An important paralog of this gene is RSPO3.

UniProtKB/Swiss-Prot: RSPO2_HUMAN, Q6UXX9
Function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon
binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are
activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression
of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling
by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a
ligand for frizzled and LRP receptors




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RSPO2 gene promoter:
         HFH-3   Pbx1a   NF-YA   FOXI1   NF-YB   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRSPO2 promoter sequence
   Search Chromatin IP Primers for RSPO2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RSPO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q23.1   Ensembl cytogenetic band:  8q23.1   HGNC cytogenetic band: 8q23.1

RSPO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RSPO2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M108981:  view genomic region     (about GC identifiers)

Start:
108,911,544 bp from pter      End:
109,095,913 bp from pter
Size:
184,370 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RSPO2_HUMAN, Q6UXX9 (See protein sequence)
Recommended Name: R-spondin-2 precursor  
Size: 243 amino acids; 28315 Da
Subunit: Interacts with WNT1. Binds heparin (By similarity). Interacts with LGR4, LGR5 and LGR6
Miscellaneous: Upon injection into mice, it induces rapid onset of crypt cell proliferation involving beta-catenin
stabilization. It also displays efficacy in a model of chemotherapy-induced intestinal mucositis
(PubMed:16357527)
Secondary accessions: B3KVP0 Q4G0U4 Q8N6X6
Alternative splicing: 3 isoforms:  Q6UXX9-1   Q6UXX9-2   Q6UXX9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RSPO2: NX_Q6UXX9

Explore proteomics data for RSPO2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn160

  • See RSPO2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001269792.1  NP_848660.3  

    ENSEMBL proteins: 
     ENSP00000428940   ENSP00000427937   ENSP00000276659   ENSP00000428614   ENSP00000430485  
     ENSP00000430010   ENSP00000429159   ENSP00000430973   ENSP00000367698  
    Reactome Protein details: Q6UXX9

    RSPO2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    3 InterPro protein domains:
     IPR000884 Thrombospondin_1_rpt
     IPR006212 Furin_repeat
     IPR009030 Growth_fac_rcpt_N_dom

    Graphical View of Domain Structure for InterPro Entry Q6UXX9

    ProtoNet protein and cluster: Q6UXX9

    1 Blocks protein domain: IPB006212 Furin-like repeat

    UniProtKB/Swiss-Prot: RSPO2_HUMAN, Q6UXX9
    Domain: The FU repeat is required for activation and stabilization of beta-catenin (By similarity)
    Similarity: Belongs to the R-spondin family
    Similarity: Contains 1 FU (furin-like) repeat
    Similarity: Contains 1 TSP type-1 domain


    Find genes that share domains with RSPO2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RSPO2_HUMAN, Q6UXX9
    Function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon
    binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are
    activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression
    of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling
    by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a
    ligand for frizzled and LRP receptors

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI--
    GO:0008201heparin binding IEA--
         
    Find genes that share ontologies with RSPO2           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 5 alleles(MGI details for Rspo2) (see all 16):
     behavior/neurological  cardiovascular system  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  hearing/vestibular/ear  homeostasis/metabolism  integument  limbs/digits/tail 
     mortality/aging  no phenotypic analysis  renal/urinary system  reproductive system  respiratory system 

    Find genes that share phenotypes with RSPO2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rspo2tm1Suda for RSPO2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RSPO2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RSPO2

    miRNA
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    hsa-mir-15a-3p (MIRT038982), hsa-mir-335-5p (MIRT018965)

    Block miRNA regulation of human, mouse, rat RSPO2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RSPO2 (see all 28):
    hsa-miR-181c hsa-let-7d hsa-let-7c hsa-let-7g hsa-miR-3200-3p hsa-miR-144 hsa-let-7a hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmidRSPO2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RSPO2

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    eBioscience FlowRNA Probe Sets ( VA1-13644) for RSPO2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RSPO2_HUMAN, Q6UXX9: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    cytoskeleton1
    cytosol1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0009986cell surface IEA--

    Find genes that share ontologies with RSPO2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RSPO2 About    
    See pathways by source

    SuperPathContained pathways About
    1Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53
    2Wnt signaling pathway (KEGG)
    Wnt Signaling Pathways0.40


    Find genes that share SuperPaths with RSPO2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for RSPO2
        Wnt Signaling Pathways


    2 Sino Biological Pathways for RSPO2
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    1 Reactome Pathway for RSPO2
        regulation of FZD by ubiquitination


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RSPO2
    Interactions:

        Search GeneGlobe Interaction Network for RSPO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for RSPO2 (Q6UXX93 ENSP000002766594) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WNT11O960143, ENSP000003255264I2D: score=1 STRING: ENSP00000325526
    DMXL1ENSP000003096904STRING: ENSP00000309690
    DMXL2ENSP000002510764STRING: ENSP00000251076
    HSPBP1ENSP000002556314STRING: ENSP00000255631
    SIL1ENSP000002651954STRING: ENSP00000265195
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001649osteoblast differentiation IEA--
    GO:0016055Wnt signaling pathway IEA--
    GO:0030282bone mineralization IEA--
    GO:0035115embryonic forelimb morphogenesis IEA--
    GO:0035116embryonic hindlimb morphogenesis IEA--

    Find genes that share ontologies with RSPO2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RSPO2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RSPO2 gene (2 alternative transcripts): 
    NM_001282863.1  NM_178565.4  

    Unigene Cluster for RSPO2:

    R-spondin 2
    Hs.444834  [show with all ESTs]
    Unigene Representative Sequence: NM_178565
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000517939(uc003ymq.3) ENST00000517781(uc003ymr.3) ENST00000276659(uc003yms.3)
    ENST00000521502 ENST00000521757 ENST00000521956 ENST00000520026 ENST00000522333
    ENST00000378439
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RSPO2 (see all 28):
    hsa-miR-181c hsa-let-7d hsa-let-7c hsa-let-7g hsa-miR-3200-3p hsa-miR-144 hsa-let-7a hsa-miR-155
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    Additional mRNA sequence: 

    AK123023.1 AK123027.1 AY358166.1 BC027938.1 BC036554.1 

    4 DOTS entries:

    DT.40207933  DT.103816  DT.100674754  DT.120639542 

    Selected AceView cDNA sequences (see all 31):

    BQ185494 AI656718 D38717 AI379477 AI417538 BU101597 AW160873 AW161744 
    AK123027 BI524005 BQ187856 AY358166 AI016251 NM_178565 AA974429 R52392 
    BI912396 BC027938 AK123023 AA723927 BX478040 R52393 CD242331 BI496605 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RSPO2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
    SP1:              -           -     -                                 
    SP2:                          -     -     -                           
    SP3:                                -                                 
    SP4:                                                                  


    ECgene alternative splicing isoforms for RSPO2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RSPO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTATTTACA
    RSPO2 Expression
    About this image


    RSPO2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Late Floor Plate Cells Mesencephalic Floor Plate
             Mesencephalic Roof Plate
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Progress Zone Cells Limb Bud
             HyStem+BMP4-induced SM30 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Progress Zone Cells Limb Bud
             HyStem+BMP4-induced SM30 cells
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Progress Zone Cells Limb Bud
             Limb Bud
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
             Extraocular Muscles
    RSPO2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RSPO2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444834
        Custom PCR Arrays for RSPO2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSPO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RSPO2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rspo21 , 5 R-spondin 2 homolog (Xenopus laevis)1, 5 92.32(n)1
    95.88(a)1
      15 (16.73 cM)5
    2394051  NM_172815.31  NP_766403.11 
     430208115 
    chicken
    (Gallus gallus)
    Aves RSPO21 R-spondin 2 80.32(n)
    83.81(a)
      420271  XM_004939997.1  XP_004940054.1 
    lizard
    (Anolis carolinensis)
    Reptilia RSPO26
    R-spondin 2
    86(a)
    1 ↔ 1
    4(11355689-11474047)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rspo21 R-spondin 2 78.05(n)
    83.54(a)
      496854  NM_001011386.1  NP_001011386.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5660541 R-spondin 3-like 70.23(n)
    72.84(a)
      566054  XM_001919423.4  XP_001919458.4 


    ENSEMBL Gene Tree for RSPO2 (if available)
    TreeFam Gene Tree for RSPO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RSPO2 gene
    RSPO32  RSPO12  RSPO42  
    3 SIMAP similar genes for RSPO2 using alignment to 6 protein entries:     RSPO2_HUMAN (see all proteins):
    RSPO4    RSPO3    RSPO1

    Find genes that share paralogs with RSPO2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RSPO2
    PGOHUM00000239732


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RSPO2 (see all 3698)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1841214661,2
    --108911062(+) AATCAA/GTATTT 1 -- ds50010--------
    rs1146460691,2
    F--108911108(+) TAGGTG/AACCAA 1 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1874844531,2
    --108911143(+) ATGCCA/GTGGTG 1 -- ds50010--------
    rs1434300341,2
    C--108911506(+) TCTAAA/GTGTAT 1 -- ds50010--------
    rs343080061,2
    C--108911630(+) GGAGA-/CCCCCC 1 -- ut310--------
    rs341292281,2
    C--108911665(+) TGTAA-/ATAGAC 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs1160019151,2
    C,F--108911708(+) GTAAAC/ACCTAA 1 -- ut311Minor allele frequency- A:0.04WA 118
    rs1913166071,2
    --108911744(+) CTTATC/TATCTC 1 -- ut310--------
    rs1823714441,2
    --108911746(+) TATTAG/TCTCAT 1 -- ut310--------
    rs1132456171,2
    F--108911793(+) CTTATC/TGGTAA 1 -- ut311Minor allele frequency- T:0.00CSA 1

    HapMap Linkage Disequilibrium report for RSPO2 (108911544 - 109095913 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RSPO2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2737420CNV Deletion23290073
    esv2737421CNV Deletion23290073
    nsv528821CNV Loss19592680

    Human Gene Mutation Database (HGMD): RSPO2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RSPO2
    DNA2.0 Custom Variant and Variant Library Synthesis for RSPO2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610575    OMIM disorders: --


    Find genes that share disorders with RSPO2           About GenesLikeMe

    Genetic Association Database (GAD): RSPO2

    Export disorders for RSPO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RSPO2 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with RSPO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. R-spondin proteins: a novel link to beta-catenin activation. (PubMed id 16357527)1, 2 Kim K.-A.... Funk W.D. (Cell Cycle 2006)
    2. R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. (PubMed id 15469841)1, 3 Kazanskaya O....Wu W. (Dev. Cell 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Reconstitution of R-spondin:LGR4:ZNRF3 adult stem cell growth factor signaling complexes with recombinant proteins produced in Escherichia coli. (PubMed id 24050775)1 Moad H.E. and Pioszak A.A. (Biochemistry 2013)
    6. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    7. Oocyte-derived R-spondin2 promotes ovarian follicle development. (PubMed id 23407710)1 Cheng Y....Hsueh A.J. (FASEB J. 2013)
    8. Recurrent R-spondin fusions in colon cancer. (PubMed id 22895193)1 Seshagiri S....de Sauvage F.J. (Nature 2012)
    9. LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor. (PubMed id 22615920)2 Gong X.... Liu Q. (PLoS ONE 2012)
    10. The role of R-spondin2 in keratinocyte proliferation and epidermal thickening in keloid scarring. (PubMed id 21160497)1 Chua A.W....Phan T.T. (J. Invest. Dermatol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 340419 HGNC: 28583 AceView: MGC35555 Ensembl:ENSG00000147655 euGenes: HUgn340419
    ECgene: RSPO2 H-InvDB: RSPO2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RSPO2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RSPO2 gene:
    Search GeneIP for patents involving RSPO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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