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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RSPO2 Gene

protein-coding   GIFtS: 50
GCID: GC08M108981

R-spondin 2

(Previous name: R-spondin 2 homolog (Xenopus laevis) )
 Explore 2 diseases affiliated with
RSPO2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RSPO2    

Aliases
for RSPO2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
R-Spondin 21 2     R-Spondin 2 Homolog (Xenopus Laevis)1
Roof Plate-Specific Spondin-22 3     R-Spondin-21
CRISTIN22 5     R-Spondin 2 Homolog2
MGC355551     HRspo21

External Ids:    HGNC: 285831   Entrez Gene: 3404192   Ensembl: ENSG000001476557   OMIM: 6105755   UniProtKB: Q6UXX93   

Export aliases for RSPO2 gene to outside databases

Previous GC identifer: GC08M104233


Summaries
for RSPO2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RSPO2:
R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1; MIM 116806) signaling (Kim
et al., 2006 (PubMed 16357527)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: RSPO2_HUMAN, Q6UXX9
Function: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the
canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an
inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled
and LRP receptors (By similarity)




Genomic Views
for RSPO2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RSPO2 gene promoter:
         HFH-3   Pbx1a   NF-YA   FOXI1   NF-YB   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RSPO2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RSPO2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RSPO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q23.1   Ensembl cytogenetic band:  8q23.1   HGNC cytogenetic band: 8q23.1

RSPO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RSPO2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M108981:  view genomic region     (about GC identifiers)

Start:
 108,911,544 bp from pter      End:
 109,095,913 bp from pter
Size:
 184,370 bases      Orientation:
 minus strand

Proteins
for RSPO2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RSPO2_HUMAN, Q6UXX9 (See protein sequence)
Recommended Name: R-spondin-2 precursor  
Size: 243 amino acids; 28315 Da
Subunit: Interacts with WNT1. Binds heparin (By similarity)
Subcellular location: Secreted (By similarity)
Miscellaneous: Upon injection into mice, it induces rapid onset of crypt cell proliferation involving beta-catenin
stabilization. It also displays efficacy in a model of chemotherapy-induced intestinal mucositis
Secondary accessions: B3KVP0 Q4G0U4 Q8N6X6
Alternative splicing: 3 isoforms:  Q6UXX9-1   Q6UXX9-2   Q6UXX9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RSPO2: NX_Q6UXX9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6UXX9

    • RSPO2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_848660.3  
    ENSEMBL proteins: 
     ENSP00000428940   ENSP00000427937   ENSP00000276659   ENSP00000428614   ENSP00000430485  
     ENSP00000430010   ENSP00000429159   ENSP00000430973   ENSP00000367698  

    Human Recombinant Protein Products: 
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: RSPO2
    OriGene Custom Protein Services for RSPO2 
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    Novus Biologicals RSPO2 Protein
    Novus Biologicals RSPO2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RSPO2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0009986cell surface IEA--


    RSPO2 for ontologies           About GeneDecksing



    RSPO2 Antibody Products: 
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    Uscn Antibodies for RSPO2
    ThermoFisher Antibodies for RSPO2

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    Uscn ELISAs and CLIAs for RSPO2

    Protein Domains /
    Families
    for RSPO2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RSPO2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR000884 Thrombospondin_1_rpt
     IPR006212 Furin_repeat
     IPR009030 Growth_fac_rcpt

    Graphical View of Domain Structure for InterPro Entry Q6UXX9

    ProtoNet protein and cluster: Q6UXX9

    1 Blocks protein family: IPB006212 Furin-like repeat

    UniProtKB/Swiss-Prot: RSPO2_HUMAN, Q6UXX9
    Domain: The FU repeat is required for activation and stabilization of beta-catenin (By similarity)
    Similarity: Belongs to the R-spondin family
    Similarity: Contains 1 FU (furin-like) repeat
    Similarity: Contains 1 TSP type-1 domain


    Function
    for RSPO2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RSPO2_HUMAN, Q6UXX9
    Function: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the
    canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an
    inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled
    and LRP receptors (By similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: RSPO2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RSPO2
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate RSPO2 (see all 28):
    hsa-miR-181c hsa-let-7d hsa-let-7c hsa-let-7g hsa-miR-3200-3p hsa-miR-144 hsa-let-7a hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmid: RSPO2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RSPO2 (see all 7)
    OriGene shRNA RFP: RSPO2
    OriGene siRNA: RSPO2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RSPO2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RSPO2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RSPO2 (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RSPO2 (NM_178565)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSPO2 

    Cell Line
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    Search LifeMap BioReagents cell lines for RSPO2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSPO2

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008201heparin binding IEA--


    RSPO2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Rspo2tm1Suda for RSPO2
         15/16 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Rspo2) (see all 16):
     behavior/neurological  cardiovascular system  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  hearing/vestibular/ear  homeostasis/metabolism  integument  limbs/digits/tail 
     mortality/aging  no phenotypic analysis  renal/urinary system  reproductive system  respiratory system 

    RSPO2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RSPO2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt Signaling Pathway
    		Wnt Signaling Pathway0.33

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 R&D Systems Pathway for RSPO2
        Wnt Signaling Pathway



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RSPO2

    1 Interacting protein for RSPO2 (Q6UXX93) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WNT11O960143I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001649osteoblast differentiation IEA--
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0030282bone mineralization IEA--
    GO:0035115embryonic forelimb morphogenesis IEA--
    GO:0035116embryonic hindlimb morphogenesis IEA--


    RSPO2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RSPO2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RSPO2
    Search CenterWatch for drugs/clinical trials and news about RSPO2 

    Transcripts
    for RSPO2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RSPO2 gene: 
    NM_178565.4  

    Unigene Cluster for RSPO2:

    R-spondin 2
    Hs.444834  [show with all ESTs]
    Unigene Representative Sequence: NM_178565
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000517939(uc003ymq.3) ENST00000517781(uc003ymr.3) ENST00000276659(uc003yms.3)
    ENST00000521502 ENST00000521757 ENST00000521956 ENST00000520026 ENST00000522333
    ENST00000378439

    miRNA
    Products:             		 OriGene 3'-UTR Clone: RSPO2
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RSPO2
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate RSPO2 (see all 28):
    hsa-miR-181c hsa-let-7d hsa-let-7c hsa-let-7g hsa-miR-3200-3p hsa-miR-144 hsa-let-7a hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmid: RSPO2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RSPO2 (see all 7)
    OriGene shRNA RFP: RSPO2
    OriGene siRNA: RSPO2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RSPO2
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RSPO2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RSPO2 (NM_178565)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RSPO2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSPO2 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RSPO2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RSPO2

    Additional cDNA sequence: 

    AK123023.1 AK123027.1 AY358166.1 BC027938.1 BC036554.1 

    4 DOTS entries:

    DT.40207933  DT.103816  DT.100674754  DT.120639542 

    24/31 AceView cDNA sequences (see all 31):

    AI417538 AW160873 AI656718 D38717 BQ185494 BU101597 AI379477 AA974429 
    NM_178565 BI524005 R52392 AA723927 BQ187856 AK123027 AK123023 R52393 
    BC027938 AY358166 AI016251 BI912396 AW161744 BX478040 AA328082 BI496604 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RSPO2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
    SP1:              -           -     -                                 
    SP2:                          -     -     -                           
    SP3:                                -                                 
    SP4:                                                                  


    ECgene alternative splicing isoforms for RSPO2

    Expression
    for RSPO2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RSPO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTATTTACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RSPO2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbZeugopodPrechondrocytic Mesenchymal CellsBone, Cartilage
    BrainChoroid PlexusBrain
    BrainHypothalamusBrain
    Neural TubeDiencephalic Floor PlateNeural Tube
    Neural TubeDiencephalic Roof PlateNeural Tube
    Neural TubeMesencephalic Floor PlateNeural Tube
    Neural TubeMesencephalic Roof PlateNeural Tube
    Skeletal MuscleExtraocular MusclesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    Sclerotome cells (Primary Cell)Bone, Cartilage, Somite
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    Trophoblast-like cells (Generation of tropho...)
    Mesendoderm (Derivation and sorti...)
    Podocalyxin+, CD24+, GCTM2- (Derivation and sorti...)
    Podocalyxin+, CD24+, GCTM2 (low) (Derivation and sorti...)

    See RSPO2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RSPO2

    SOURCE GeneReport for Unigene cluster: Hs.444834
        SABiosciences Custom PCR Arrays for RSPO2
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RSPO2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSPO2

    Orthologs
    for RSPO2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for RSPO2 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rspo21 , 5 R-spondin 2 homolog (Xenopus laevis)1, 5 92.32(n)1
    95.88(a)1    		   15 (16.73 cM)5
    2394051  NM_172815.31  NP_766403.11 
     430208115 
    chicken
    (Gallus gallus)    		 Aves RSPO21 R-spondin 2 81.11(n)
    84.76(a)    		   420271  XM_418383.2  XP_418383.2 
    lizard
    (Anolis carolinensis)    		 Reptilia RSPO26
    		 --
    		 78(a)
    		 1 ↔ 1
    		 4(11423368-11438880)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5660541 R-spondin 3-like 70.4(n)
    73.03(a)    		   566054  XM_001919423.3  XP_001919458.3 


    ENSEMBL Gene Tree for RSPO2 (if available)
    TreeFam Gene Tree for RSPO2 (if available) 

    Paralogs
    for RSPO2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RSPO2 gene
    RSPO32  RSPO12  RSPO42  
    3 SIMAP similar genes for RSPO2 using alignment to 6 protein entries:     RSPO2_HUMAN (see all proteins):
    RSPO4    RSPO3    RSPO1

    RSPO2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RSPO2
    PGOHUM00000239732


    Genomic Variants
    for RSPO2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3171 NCBI SNPs in RSPO2 are shown (see all 3171)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1841214661,2
    		--108911062(+) AATCAA/GTATTT 1 -- ds50010--------
    rs1146460691,2
    		F,--108911108(+) TAGGTG/AACCAA 1 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1874844531,2
    		--108911143(+) ATGCCA/GTGGTG 1 -- ds50010--------
    rs1434300341,2
    		--108911506(+) TCTAAA/GTGTAT 1 -- ds50010--------
    rs341292281,2
    		C,--108911665(+) TGTAA-/ATAGAC 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs1160019151,2
    		C,F,--108911708(+) GTAAAC/ACCTAA 1 -- ut311Minor allele frequency- A:0.04WA 118
    rs1913166071,2
    		--108911744(+) CTTATC/TATCTC 1 -- ut310--------
    rs1823714441,2
    		--108911746(+) TATTAG/TCTCAT 1 -- ut310--------
    rs1132456171,2
    		--108911793(+) CTTATC/TGGTAA 1 -- ut311Minor allele frequency- T:0.00CSA 1
    rs1468955511,2
    		--108911849(+) CCAATG/TCAAGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RSPO2 (108911544 - 109095913 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RSPO2: --
    Human Gene Mutation Database (HGMD): RSPO2

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    Disorders / Diseases
    for RSPO2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RSPO2 for disorders           About GeneDecksing

    OMIM gene information: 610575    OMIM disorders: --

    2 diseases for RSPO2:    About MalaCards
    keloids    osteoarthritis


    Export disorders for RSPO2 gene to outside databases

    Publications
    for RSPO2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RSPO2 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with RSPO2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. R-spondin proteins: a novel link to beta-catenin activation. (PubMed id 16357527)1, 2 Kim K.-A.... Funk W.D. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. R-Spondin2 is a secreted activator of Wnt/beta-cateni n signaling and is required for Xenopus myogenesis. (PubMed id 15469841)1, 3 Kazanskaya O....Wu W. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Recurrent R-spondin fusions in colon cancer. (PubMed id 22895193)1 Seshagiri S....de Sauvage F.J. (2012)
    6. Wnt signaling and Dupuytren's disease. (PubMed id 21732829)1 Dolmans G.H.... . (2011)
    7. The role of R-spondin2 in keratinocyte proliferation and epidermal thickening in keloid scarring. (PubMed id 21160497)1 Chua A.W....Phan T.T. (2011)
    8. R-spondins are newly recognized players in osteoarthr itis that regulate Wnt signaling in osteoblasts. (PubMed id 22127703)1 Abed A.8....Lajeunesse D. (2011)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)

    External Searches for RSPO2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    Genome Databases showing RSPO2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 340419 HGNC: 28583 AceView: MGC35555 Ensembl:ENSG00000147655 euGenes: HUgn340419
    ECgene: RSPO2 H-InvDB: RSPO2

    Other Databases showing RSPO2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RSPO2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RSPO2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RSPO2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RSPO2 gene:
    Search GeneIP for patents involving RSPO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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