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Aliases & Descriptions for RSPO2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CRISTIN2 2 | | MGC35555 1, 2 | | MGC43342 2 | | hRspo2 3 |
| | | Descriptions |
|---|
| R-spondin 2 homolog (Xenopus laevis) 2 | | R-spondin family, member 2 2 | | Roof plate-specific spondin-2 3 |
|
| | Search outside databases for aliases for RSPO2 gene |
Summaries for RSPO2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for RSPO2: R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1; MIM 116806) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM] UniProtKB/Swiss-Prot: RSPO2_HUMAN, Q6UXX9Function: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Probably also acts as a ligand for frizzled and LRP receptors (By similarity) |
Genomic Location for RSPO2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RSPO2 gene 
Entrez Gene cytogenetic band: 8q23.1 Ensembl cytogenetic band: 8q23.1 HGNC cytogenetic band: 8q23.1RSPO2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M108981:
(about GC identifiers)
Start:
|
108,980,721 bp from pter |
End:
|
109,165,052 bp from pter |
Size:
|
184,332 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000008.9 NT_008046.15
| Proteins for RSPO2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RSPO2_HUMAN, Q6UXX9 (See
protein sequence)Recommended Name: R-spondin-2 precursor Size: 243 amino acids; 28315 Da
Subunit: Interacts with WNT1. Binds heparin (By similarity)
Subcellular location: Secreted (By similarity)
Miscellaneous: Upon injection into mice, it induces rapid onset of crypt cell proliferation involving beta-catenin stabilization. It also displays efficacy in a model of chemotherapy-induced intestinal mucositis
Secondary accessions: Q4G0U4 Q8N6X6Alternative splicing: 3 isoforms: Q6UXX9-1 Q6UXX9-2 Q6UXX9-3 REFSEQ proteins: NP_848660.3
ENSEMBL proteins: ENSP00000276659 ENSP00000367698
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | About this table
Antibodies for RSPO2: Assays for RSPO2: | Protein
Domains/ Families for RSPO2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q6UXX9
ProtoNet protein and cluster: Q6UXX9 1 Blocks protein family: IPB006212 Furin-like repeat
UniProtKB/Swiss-Prot: RSPO2_HUMAN, Q6UXX9Domain: The FU repeat is required for activation and stabilization of beta-catenin (By similarity)Similarity: Belongs to the R-spondin familySimilarity: Contains 1 FU (furin-like) repeatSimilarity: Contains 1 TSP type-1 domain | Gene Function for RSPO2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_178565
Applied Biosystems Silencer® siRNAs for RSPO2
Sigma-Aldrich siRNA for RSPO2  Sigma-Aldrich shRNA Panels and shRNA for RSPO2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_178565                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_178565                                  untagged cDNA clones in CMV expression vector (see all 2): NM_178565 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_178565
UniProtKB/Swiss-Prot: RSPO2_HUMAN, Q6UXX9Function: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Probably also acts as a ligand for frizzled and LRP receptors (By similarity)13 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Rspo2):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008201 | heparin binding |
IEA | -- | About this table | Pathways & Interactions for RSPO2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
3 Interacting proteins for RSPO2 (ENSP000002766593) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016055 | Wnt receptor signaling pathway |
IEA | -- | | GO:0050896 | response to stimulus |
IEA | -- | About this table
|
Drugs & Compounds for RSPO2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for RSPO2
|
Transcripts for RSPO2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_178565
Sigma-Aldrich siRNA for RSPO2  Sigma-Aldrich shRNA Panels and shRNA for RSPO2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_178565 REFSEQ mRNAs for RSPO2 gene: NM_178565.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_178565               OriGene GFP tagged cDNA clone in CMV expression vector: NM_178565                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_178565                                  untagged cDNA clones in CMV expression vector (see all 2): NM_178565  Additional cDNA sequence: AK123023.1 AK123027.1 AY358166.1 BC027938.1 BC036554.1 4 DOTS entries: DT.40207933 DT.103816 DT.100674754 DT.120639542 24/31 AceView cDNA sequences (see all 31
):BQ185494 D38717 AI417538 BU101597 AI656718 AI379477 AW160873 BX478040 AA974429 NM_178565 AA723927 AK123027 AK123023 AW161744 AY358166 R52393 BI912396 BI524005 BQ187856 AI016251 R52392 BC027938 BI496605 CB854676
highest scoring ESTs for RSPO2:AI656718 AA723927 AA974429 AI417538 AI797252 AK123023 AW160873 AW161137 AW183304 AY358166 Unigene Cluster for RSPO2: R-spondin 2 homolog (Xenopus laevis) Hs.444834 [show with all ESTs]Unigene Representative Sequence: NM_178565
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for RSPO2
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | |
| SP1: | |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for RSPO2
2 Ensembl transcripts including schematic representations: ENST00000276659
ENST00000378439
|
Expression for RSPO2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RSPO2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RSPO2
1 / 2 / 3 4 probe-sets matching RSPO2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TCTATTTACA
SOURCE GeneReport for Unigene cluster: Hs.444834
|
Orthologs for RSPO2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RSPO2 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for RSPO2
ENSEMBL Gene Tree for RSPO2 | Paralogs for RSPO2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RSPO2 gene
- RSPO32 RSPO12 RSPO42
|
SNPs/Variants for RSPO2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RSPO2 (up to first 250kb)
|
Disorders & Mutations for RSPO2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 610575
|
Medical News for RSPO2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RSPO2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 8 PubMed articles for RSPO2 gene: |
Search for RSPO2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RSPO2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RSPO2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RSPO2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RSPO2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RSPO2:

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Incremental update: 13 Oct 2009
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