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Aliases for RSPO2 Gene

Aliases for RSPO2 Gene

  • R-Spondin 2 2 3
  • Roof Plate-Specific Spondin-2 3 4
  • CRISTIN2 3 6
  • R-Spondin 2 Homolog (Xenopus Laevis) 2
  • R-Spondin 2 Homolog 3
  • R-Spondin-2 3
  • HRspo2 4

External Ids for RSPO2 Gene

Previous GeneCards Identifiers for RSPO2 Gene

  • GC08M108981
  • GC08M104233

Summaries for RSPO2 Gene

Entrez Gene Summary for RSPO2 Gene

  • R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1; MIM 116806) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RSPO2 Gene

RSPO2 (R-Spondin 2) is a Protein Coding gene. Among its related pathways are Wnt signaling pathway (KEGG) and Non-Canonical Wnt Pathway. GO annotations related to this gene include receptor binding and heparin binding. An important paralog of this gene is RSPO3.

UniProtKB/Swiss-Prot for RSPO2 Gene

  • Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSPO2 Gene

Genomics for RSPO2 Gene

Regulatory Elements for RSPO2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RSPO2 Gene

Start:
107,899,316 bp from pter
End:
108,083,685 bp from pter
Size:
184,370 bases
Orientation:
Minus strand

Genomic View for RSPO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RSPO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSPO2 Gene

Proteins for RSPO2 Gene

  • Protein details for RSPO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXX9-RSPO2_HUMAN
    Recommended name:
    R-spondin-2
    Protein Accession:
    Q6UXX9
    Secondary Accessions:
    • B3KVP0
    • Q4G0U4
    • Q8N6X6

    Protein attributes for RSPO2 Gene

    Size:
    243 amino acids
    Molecular mass:
    28315 Da
    Quaternary structure:
    • Interacts with WNT1. Binds heparin (By similarity). Interacts with LGR4, LGR5 and LGR6.
    Miscellaneous:
    • Upon injection into mice, it induces rapid onset of crypt cell proliferation involving beta-catenin stabilization. It also displays efficacy in a model of chemotherapy-induced intestinal mucositis (PubMed:16357527).

    Alternative splice isoforms for RSPO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RSPO2 Gene

Proteomics data for RSPO2 Gene at MOPED

Post-translational modifications for RSPO2 Gene

  • Glycosylation at Asn160
  • Modification sites at PhosphoSitePlus

Other Protein References for RSPO2 Gene

Antibody Products

No data available for DME Specific Peptides for RSPO2 Gene

Domains for RSPO2 Gene

Gene Families for RSPO2 Gene

HGNC:

Protein Domains for RSPO2 Gene

Suggested Antigen Peptide Sequences for RSPO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UXX9

UniProtKB/Swiss-Prot:

RSPO2_HUMAN :
  • Q6UXX9
Domain:
  • The FU repeat is required for activation and stabilization of beta-catenin.
  • Contains 1 TSP type-1 domain.
Family:
  • Belongs to the R-spondin family.
Similarity:
  • Contains 1 FU (furin-like) repeat.
genes like me logo Genes that share domains with RSPO2: view

Function for RSPO2 Gene

Molecular function for RSPO2 Gene

UniProtKB/Swiss-Prot Function:
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors.

Gene Ontology (GO) - Molecular Function for RSPO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
GO:0005102 receptor binding IPI 22615920
GO:0005515 protein binding IPI 25416956
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with RSPO2: view
genes like me logo Genes that share phenotypes with RSPO2: view

Animal Models for RSPO2 Gene

MGI Knock Outs for RSPO2:

Animal Model Products

miRNA for RSPO2 Gene

miRTarBase miRNAs that target RSPO2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RSPO2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RSPO2 Gene

Localization for RSPO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RSPO2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RSPO2 Gene COMPARTMENTS Subcellular localization image for RSPO2 gene
Compartment Confidence
extracellular 3
cytoskeleton 1
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RSPO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with RSPO2: view

Pathways for RSPO2 Gene

genes like me logo Genes that share pathways with RSPO2: view

Pathways by source for RSPO2 Gene

2 Sino Biological pathways for RSPO2 Gene
1 R&D Systems pathway for RSPO2 Gene

Gene Ontology (GO) - Biological Process for RSPO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0030282 bone mineralization IEA --
GO:0035115 embryonic forelimb morphogenesis IEA --
GO:0035116 embryonic hindlimb morphogenesis IEA --
genes like me logo Genes that share ontologies with RSPO2: view

Transcripts for RSPO2 Gene

Unigene Clusters for RSPO2 Gene

R-spondin 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RSPO2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RSPO2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: - - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for RSPO2 Gene

GeneLoc Exon Structure for
RSPO2
ECgene alternative splicing isoforms for
RSPO2

Expression for RSPO2 Gene

mRNA expression in normal human tissues for RSPO2 Gene

mRNA differential expression in normal tissues according to GTEx for RSPO2 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (6.6), Brain - Frontal Cortex (BA9) (6.4), Colon - Sigmoid (5.6), Brain - Cortex (4.6), Brain - Hypothalamus (4.4), and Brain - Anterior cingulate cortex (BA24) (4.3).

Protein differential expression in normal tissues for RSPO2 Gene

This gene is overexpressed in Esophagus (29.1), Colon muscle (25.7), and Breast (8.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RSPO2 Gene

SOURCE GeneReport for Unigene cluster for RSPO2 Gene Hs.444834

genes like me logo Genes that share expressions with RSPO2: view

Expression partners for RSPO2 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RSPO2 Gene

Orthologs for RSPO2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RSPO2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RSPO2 35
  • 94.65 (n)
  • 97.12 (a)
RSPO2 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RSPO2 35
  • 94.92 (n)
  • 97.53 (a)
RSPO2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rspo2 35
  • 92.32 (n)
  • 95.88 (a)
Rspo2 16
Rspo2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RSPO2 35
  • 99.73 (n)
  • 99.59 (a)
RSPO2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rspo2 35
  • 93.85 (n)
  • 95.63 (a)
oppossum
(Monodelphis domestica)
Mammalia RSPO2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RSPO2 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves RSPO2 35
  • 80.32 (n)
  • 83.81 (a)
RSPO2 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RSPO2 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rspo2 35
  • 78.05 (n)
  • 83.54 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC566054 35
  • 70.23 (n)
  • 72.84 (a)
rspo2 36
  • 71 (a)
OneToOne
Species with no ortholog for RSPO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RSPO2 Gene

ENSEMBL:
Gene Tree for RSPO2 (if available)
TreeFam:
Gene Tree for RSPO2 (if available)

Paralogs for RSPO2 Gene

Paralogs for RSPO2 Gene

Selected SIMAP similar genes for RSPO2 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for RSPO2 Gene

genes like me logo Genes that share paralogs with RSPO2: view

Variants for RSPO2 Gene

Sequence variations from dbSNP and Humsavar for RSPO2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs374810 -- 108,083,801(+) TTCCA(A/G)AGTGC upstream-variant-2KB
rs388681 -- 108,085,448(+) CTTCC(A/T)TAGTT upstream-variant-2KB
rs423940 -- 108,081,350(+) TTACA(C/T)ACAAT intron-variant
rs429315 -- 108,081,840(+) AGAGC(A/G)AAGTG intron-variant
rs446402 -- 108,085,644(+) GTTTA(A/G)TAAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RSPO2 Gene

Variant ID Type Subtype PubMed ID
esv2737420 CNV Deletion 23290073
nsv528821 CNV Loss 19592680
esv2737421 CNV Deletion 23290073

Relevant External Links for RSPO2 Gene

HapMap Linkage Disequilibrium report
RSPO2
Human Gene Mutation Database (HGMD)
RSPO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSPO2 Gene

Disorders for RSPO2 Gene

Relevant External Links for RSPO2

Genetic Association Database (GAD)
RSPO2

No disorders were found for RSPO2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RSPO2 Gene

Publications for RSPO2 Gene

  1. LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor. (PMID: 22615920) Gong X. … Liu Q. (PLoS ONE 2012) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. (PMID: 15469841) Kazanskaya O. … Wu W. (Dev. Cell 2004) 2 3
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. R-spondin proteins: a novel link to beta-catenin activation. (PMID: 16357527) Kim K.-A. … Funk W.D. (Cell Cycle 2006) 3 4

Products for RSPO2 Gene

Sources for RSPO2 Gene

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