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Aliases for RSPH3 Gene

Aliases for RSPH3 Gene

  • Radial Spoke 3 Homolog (Chlamydomonas) 2 3
  • Radial Spoke Head-Like Protein 2 3 4
  • A-Kinase Anchor Protein RSPH3 3 4
  • Radial Spokehead-Like 2 2 3
  • RSHL2 3 4
  • RSP3 3 4
  • Radial Spoke Head Protein 3 Homolog 3
  • Radial Spoke Head 3 Homolog 3
  • Radial Spoke Protein 3 3
  • DJ111C20.1 3

External Ids for RSPH3 Gene

Previous Symbols for RSPH3 Gene

  • RSHL2

Summaries for RSPH3 Gene

GeneCards Summary for RSPH3 Gene

RSPH3 (Radial Spoke 3 Homolog (Chlamydomonas)) is a Protein Coding gene.

UniProtKB/Swiss-Prot for RSPH3 Gene

  • Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia.

Gene Wiki entry for RSPH3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSPH3 Gene

Genomics for RSPH3 Gene

Genomic Location for RSPH3 Gene

Start:
158,972,871 bp from pter
End:
159,000,392 bp from pter
Size:
27,522 bases
Orientation:
Minus strand

Genomic View for RSPH3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RSPH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSPH3 Gene

Proteins for RSPH3 Gene

  • Protein details for RSPH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UC2-RSPH3_HUMAN
    Recommended name:
    Radial spoke head protein 3 homolog
    Protein Accession:
    Q86UC2
    Secondary Accessions:
    • Q96LQ5
    • Q96LX2
    • Q9BX75

    Protein attributes for RSPH3 Gene

    Size:
    560 amino acids
    Molecular mass:
    63687 Da
    Quaternary structure:
    • Interacts with phosphorylated MAPK1. Interacts with MEK1. Interact with PKA regulatory subunits PRKAR1A and PRKAR1B.
    SequenceCaution:
    • Sequence=AAK26432.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71544.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19235.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19236.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RSPH3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RSPH3 Gene

Proteomics data for RSPH3 Gene at MOPED

Post-translational modifications for RSPH3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RSPH3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RSPH3 Gene

Domains for RSPH3 Gene

Protein Domains for RSPH3 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

RSPH3_HUMAN
Family:
  • Belongs to the flagellar radial spoke RSP3 family.:
    • Q86UC2
genes like me logo Genes that share domains with RSPH3: view

No data available for Gene Families for RSPH3 Gene

Function for RSPH3 Gene

Molecular function for RSPH3 Gene

UniProtKB/Swiss-Prot Function: Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia.

Gene Ontology (GO) - Molecular Function for RSPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RSPH3: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RSPH3 Gene

Localization for RSPH3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RSPH3 Gene COMPARTMENTS Subcellular localization image for RSPH3 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for RSPH3 Gene

Pathways for RSPH3 Gene

SuperPathways for RSPH3 Gene

No Data Available

Interacting Proteins for RSPH3 Gene

Gene Ontology (GO) - Biological Process for RSPH3 Gene

None

No data available for Pathways by source for RSPH3 Gene

Transcripts for RSPH3 Gene

Unigene Clusters for RSPH3 Gene

Radial spoke 3 homolog (Chlamydomonas):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RSPH3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9
SP1: - - - -
SP2: - -
SP3: - - -
SP4: - - - - - - -
SP5: - -
SP6: -

Relevant External Links for RSPH3 Gene

GeneLoc Exon Structure for
RSPH3
ECgene alternative splicing isoforms for
RSPH3

Expression for RSPH3 Gene

mRNA expression in normal human tissues for RSPH3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RSPH3 Gene

SOURCE GeneReport for Unigene cluster for RSPH3 Gene Hs.154628

genes like me logo Genes that share expressions with RSPH3: view

Orthologs for RSPH3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RSPH3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RSPH3 36
  • 99.23 (n)
  • 98.57 (a)
RSPH3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RSPH3 36
  • 80.13 (n)
  • 75.47 (a)
RSPH3 37
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RSPH3 36
  • 81.55 (n)
  • 75.53 (a)
RSPH3 37
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rsph3a 16
Rsph3a 37
  • 64 (a)
OneToMany
Rsph3b 36
  • 81.19 (n)
  • 82.21 (a)
Rsph3b 37
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RSPH3 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RSPH3 37
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rsph3 36
  • 75.56 (n)
  • 67.67 (a)
chicken
(Gallus gallus)
Aves RSPH3 36
  • 69.36 (n)
  • 69.88 (a)
RSPH3 37
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 57 (a)
OneToMany
-- 37
  • 54 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.1504 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rsph3 36
  • 66.87 (n)
  • 68.88 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4654 36
zebrafish
(Danio rerio)
Actinopterygii rsph3 36
  • 63.37 (n)
  • 62.96 (a)
rsph3 37
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG32392 36
  • 45.42 (n)
  • 42.03 (a)
CG32392 37
  • 22 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14205 36
Species with no ortholog for RSPH3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RSPH3 Gene

ENSEMBL:
Gene Tree for RSPH3 (if available)
TreeFam:
Gene Tree for RSPH3 (if available)

Paralogs for RSPH3 Gene

No data available for Paralogs for RSPH3 Gene

Variants for RSPH3 Gene

Sequence variations from dbSNP and Humsavar for RSPH3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs720412 -- 158,984,725(-) AAACT(A/G)AGGCC intron-variant
rs768994 - 158,978,316(-) GCTAA(C/T)GAATG missense, reference, nc-transcript-variant
rs2092540 -- 158,995,412(-) tgcag(C/T)cctgt intron-variant
rs2143650 -- 158,983,955(-) GGTTT(C/T)GCCAT intron-variant
rs2143651 -- 158,983,830(-) AACTC(A/G)ATATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RSPH3 Gene

Variant ID Type Subtype PubMed ID
nsv886798 CNV Gain 21882294
esv33150 CNV Loss 17666407
esv33909 CNV Loss 17666407
esv33554 CNV Loss 17666407
esv32758 CNV Loss 17666407
esv2668232 CNV Deletion 23128226

Relevant External Links for RSPH3 Gene

HapMap Linkage Disequilibrium report
RSPH3

Disorders for RSPH3 Gene

Relevant External Links for RSPH3

Genetic Association Database (GAD)
RSPH3
genes like me logo Genes that share disorders with RSPH3: view

No data available for UniProtKB/Swiss-Prot for RSPH3 Gene

Publications for RSPH3 Gene

  1. Radial spoke protein 3 is a mammalian protein kinase A-anchoring protein that binds ERK1/2. (PMID: 19684019) Jivan A. … Cobb M.H. (J. Biol. Chem. 2009) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Genomic organisation and nervous system expression of radial spoke protein 3. (PMID: 15225872) Koukoulas I. … Tan S.S. (Gene 2004) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for RSPH3 Gene

Sources for RSPH3 Gene

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