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Aliases for RSPH3 Gene

Aliases for RSPH3 Gene

  • Radial Spoke 3 Homolog (Chlamydomonas) 2 3
  • Radial Spoke Head-Like Protein 2 3 4
  • A-Kinase Anchor Protein RSPH3 3 4
  • Radial Spokehead-Like 2 2 3
  • RSHL2 3 4
  • RSP3 3 4
  • Radial Spoke Head Protein 3 Homolog 3
  • Radial Spoke Head 3 Homolog 3
  • Radial Spoke Protein 3 3
  • DJ111C20.1 3

External Ids for RSPH3 Gene

Previous HGNC Symbols for RSPH3 Gene

  • RSHL2

Previous GeneCards Identifiers for RSPH3 Gene

  • GC06M159317
  • GC06M159318
  • GC06M159397
  • GC06M156868

Summaries for RSPH3 Gene

GeneCards Summary for RSPH3 Gene

RSPH3 (Radial Spoke 3 Homolog (Chlamydomonas)) is a Protein Coding gene.

UniProtKB/Swiss-Prot for RSPH3 Gene

  • Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia.

Gene Wiki entry for RSPH3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSPH3 Gene

Genomics for RSPH3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RSPH3 Gene

158,972,871 bp from pter
159,000,392 bp from pter
27,522 bases
Minus strand

Genomic View for RSPH3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RSPH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSPH3 Gene

Proteins for RSPH3 Gene

  • Protein details for RSPH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Radial spoke head protein 3 homolog
    Protein Accession:
    Secondary Accessions:
    • Q96LQ5
    • Q96LX2
    • Q9BX75

    Protein attributes for RSPH3 Gene

    560 amino acids
    Molecular mass:
    63687 Da
    Quaternary structure:
    • Interacts with phosphorylated MAPK1. Interacts with MEK1. Interact with PKA regulatory subunits PRKAR1A and PRKAR1B.
    • Sequence=AAK26432.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71544.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19235.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19236.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RSPH3 Gene


neXtProt entry for RSPH3 Gene

Proteomics data for RSPH3 Gene at MOPED

Post-translational modifications for RSPH3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RSPH3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RSPH3 Gene

Domains for RSPH3 Gene

Protein Domains for RSPH3 Gene


Suggested Antigen Peptide Sequences for RSPH3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the flagellar radial spoke RSP3 family.
  • Belongs to the flagellar radial spoke RSP3 family.
genes like me logo Genes that share domains with RSPH3: view

No data available for Gene Families for RSPH3 Gene

Function for RSPH3 Gene

Molecular function for RSPH3 Gene

UniProtKB/Swiss-Prot Function:
Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia.

Gene Ontology (GO) - Molecular Function for RSPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RSPH3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RSPH3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RSPH3 Gene

Localization for RSPH3 Gene

Subcellular locations from

Jensen Localization Image for RSPH3 Gene COMPARTMENTS Subcellular localization image for RSPH3 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RSPH3 Gene

Pathways for RSPH3 Gene

SuperPathways for RSPH3 Gene

No Data Available

Interacting Proteins for RSPH3 Gene

Gene Ontology (GO) - Biological Process for RSPH3 Gene


No data available for Pathways by source for RSPH3 Gene

Transcripts for RSPH3 Gene

Unigene Clusters for RSPH3 Gene

Radial spoke 3 homolog (Chlamydomonas):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RSPH3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RSPH3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9
SP1: - - - -
SP2: - -
SP3: - - -
SP4: - - - - - - -
SP5: - -
SP6: -

Relevant External Links for RSPH3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RSPH3 Gene

mRNA expression in normal human tissues for RSPH3 Gene

Protein differential expression in normal tissues for RSPH3 Gene

This gene is overexpressed in Heart (62.9) and Testis (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RSPH3 Gene

SOURCE GeneReport for Unigene cluster for RSPH3 Gene Hs.154628

genes like me logo Genes that share expressions with RSPH3: view

Expression partners for RSPH3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RSPH3 Gene

Orthologs for RSPH3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RSPH3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RSPH3 35
  • 80.13 (n)
  • 75.47 (a)
RSPH3 36
  • 65 (a)
(Canis familiaris)
Mammalia RSPH3 35
  • 81.55 (n)
  • 75.53 (a)
RSPH3 36
  • 70 (a)
(Mus musculus)
Mammalia Rsph3b 35
  • 81.19 (n)
  • 82.21 (a)
Rsph3a 16
Rsph3a 36
  • 64 (a)
Rsph3b 36
  • 72 (a)
(Pan troglodytes)
Mammalia RSPH3 35
  • 99.23 (n)
  • 98.57 (a)
RSPH3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rsph3 35
  • 75.56 (n)
  • 67.67 (a)
(Monodelphis domestica)
Mammalia RSPH3 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia RSPH3 36
  • 53 (a)
(Gallus gallus)
Aves RSPH3 35
  • 69.36 (n)
  • 69.88 (a)
RSPH3 36
  • 57 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 57 (a)
-- 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rsph3 35
  • 66.87 (n)
  • 68.88 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1504 35
(Danio rerio)
Actinopterygii rsph3 35
  • 63.37 (n)
  • 62.96 (a)
rsph3 36
  • 62 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4654 35
fruit fly
(Drosophila melanogaster)
Insecta CG32392 35
  • 45.42 (n)
  • 42.03 (a)
CG32392 36
  • 22 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14205 35
Species with no ortholog for RSPH3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RSPH3 Gene

Gene Tree for RSPH3 (if available)
Gene Tree for RSPH3 (if available)

Paralogs for RSPH3 Gene

No data available for Paralogs for RSPH3 Gene

Variants for RSPH3 Gene

Sequence variations from dbSNP and Humsavar for RSPH3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs720412 -- 158,984,725(-) AAACT(A/G)AGGCC intron-variant
rs768994 - 158,978,316(-) GCTAA(C/T)GAATG missense, reference, nc-transcript-variant
rs2092540 -- 158,995,412(-) tgcag(C/T)cctgt intron-variant
rs2143650 -- 158,983,955(-) GGTTT(C/T)GCCAT intron-variant
rs2143651 -- 158,983,830(-) AACTC(A/G)ATATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RSPH3 Gene

Variant ID Type Subtype PubMed ID
nsv886798 CNV Gain 21882294
esv33150 CNV Loss 17666407
esv33909 CNV Loss 17666407
esv33554 CNV Loss 17666407
esv32758 CNV Loss 17666407
esv2668232 CNV Deletion 23128226

Relevant External Links for RSPH3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSPH3 Gene

Disorders for RSPH3 Gene

Relevant External Links for RSPH3

Genetic Association Database (GAD)

No disorders were found for RSPH3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RSPH3 Gene

Publications for RSPH3 Gene

  1. Radial spoke protein 3 is a mammalian protein kinase A-anchoring protein that binds ERK1/2. (PMID: 19684019) Jivan A. … Cobb M.H. (J. Biol. Chem. 2009) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Genomic organisation and nervous system expression of radial spoke protein 3. (PMID: 15225872) Koukoulas I. … Tan S.S. (Gene 2004) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for RSPH3 Gene

Sources for RSPH3 Gene

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