RSPH3 Gene
protein-coding GIFtS: 45
GCID: GC06M159397
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radial spoke 3 homolog (Chlamydomonas)(Previous name: radial spokehead-like 2 )
(Previous symbol: RSHL2)
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Aliases
for RSPH3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Radial Spoke 3 Homolog (Chlamydomonas)1 2 | | Radial Spoke Head-Like Protein 22 3 | | RSHL21 2 3 | | Radial Spoke Head 3 Homolog2 | | RSP31 2 3 | | Radial Spoke Head Protein 3 Homolog2 | | DJ111C20.11 | | Radial Spoke Protein 32 | | Radial Spokehead-Like 21 2 | | |
Export aliases for RSPH3 gene to outside databasesPrevious GC identifers: GC06M159317 GC06M159318 GC06M156868 |
Summaries
for RSPH3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for RSPH3
|
Genomic Views
for RSPH3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RSPH3 gene promoter:
AML1a HSF1 (long) C/EBPalpha HNF-4alpha1 Max PPAR-gamma1 FOXO4 HSF1short PPAR-gamma2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for RSPH3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RSPH3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q25.3 Ensembl cytogenetic band: 6q25.3 HGNC cytogenetic band: 6q25.3RSPH3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M159397: view genomic region
(about GC identifiers)
Start:
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159,397,312 bp from pter |
End:
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159,421,219 bp from pter |
Size:
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23,908 bases |
Orientation:
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minus strand |
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Proteins
for RSPH3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RSPH3_HUMAN, Q86UC2 (See
protein sequence)Recommended Name: Radial spoke head protein 3 homolog Size: 560 amino acids; 63687 Da
Sequence caution: Sequence=AAK26432.1; Type=Erroneous initiation; Sequence=BAB71544.1; Type=Erroneous initiation;Sequence=CAI19235.1; Type=Erroneous initiation; Sequence=CAI19236.1; Type=Erroneous initiation;
Secondary accessions: Q96LQ5 Q96LX2 Q9BX75Alternative splicing: 2 isoforms: Q86UC2-1 Q86UC2-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RSPH3: NX_Q86UC2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86UC2
RSPH3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_114130.3
ENSEMBL proteins: ENSP00000356036 ENSP00000393195 ENSP00000252655 ENSP00000297262
Human Recombinant Protein Products:
RSPH3 Antibody Products:
Assay Products for RSPH3: |
Protein
Domains /
Families
for RSPH3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RSPH3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q86UC2ProtoNet protein and cluster: Q86UC2 UniProtKB/Swiss-Prot: RSPH3_HUMAN, Q86UC2Similarity: Belongs to the flagellar radial spoke RSP3 family |
Function
for RSPH3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RSPH3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RSPH3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RSPH3 (NM_031924) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RSPH3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSPH3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSPH3 |
|
Pathways & Interactions
for RSPH3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RSPH3
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for RSPH3 (Q86UC22, 3 ENSP000002526554) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for RSPH3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RSPH3
Search CenterWatch for drugs/clinical trials and news about RSPH3
|
Transcripts
for RSPH3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RSPH3 gene: NM_031924.4 Unigene Cluster for RSPH3: Radial spoke 3 homolog (Chlamydomonas) Hs.154628 [show with all ESTs]Unigene Representative Sequence: NM_0319244 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367069(uc003qrx.3 uc010kju.3) ENST00000449822 ENST00000252655
ENST00000297262
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RSPH3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RSPH3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RSPH3 (NM_031924) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RSPH3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSPH3 |
Additional cDNA sequence: AF353618.1 AK057655.1 AK057931.1 BC011590.1 BC035675.1 BC050604.1 4 DOTS entries: DT.40308532 DT.95369103 DT.121333820 DT.75185816 24/53 AceView cDNA sequences (see all 53): BX111419 BM541421 CR624562 NM_031924 BC011590 AI245285 BC050604 BE503271 BM021845 BU632337 AI125143 AW138407 BM982853 AI126047 BP369066 AF353618 AK057655 CK904165 BM021983 AK057931 AI470552 AI341051 CA416793 BI491656
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RSPH3 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 |
|---|
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| SP1: | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RSPH3
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Expression
for RSPH3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RSPH3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCACAGACAC
About this image
See RSPH3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RSPH3
SOURCE GeneReport for Unigene cluster: Hs.154628
SABiosciences Custom PCR Arrays for RSPH3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RSPH3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RSPH3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RSPH3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RSPH3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSPH3 |
Orthologs
for RSPH3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RSPH3 gene from 6/23 species (see all 23) About this table
ENSEMBL Gene Tree for RSPH3 (if available)
TreeFam Gene Tree for RSPH3 (if available) |
Paralogs
for RSPH3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RSPH3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RSPH3 (159397312 - 159421219 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for RSPH3
2 CNVs: 7537 7538
1 Indel: 11271 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RSPH3 |
|
Disorders
/ Diseases
for RSPH3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RSPH3 for disorders About GeneDecksing
2  diseases for RSPH3: About MalaCardssleeping sickness cryptorchidism
Export disorders for RSPH3 gene to outside databases
|
Publications
for RSPH3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RSPH3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RSPH3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Radial spoke protein 3 is a mammalian protein kinase A-anchoring protein that binds ERK1/2. (PubMed id 19684019)1 Jivan A....Cobb M.H. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Genomic organisation and nervous system expression of radial spoke protein 3. (PubMed id 15225872)1 Koukoulas I....Tan S.S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
|
External Searches for RSPH3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing RSPH3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RSPH3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RSPH3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RSPH3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RSPH3 gene:
Search GeneIP for patents involving RSPH3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RSPH3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RSPH3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RSPH3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RSPH3 | | | OriGene Protein Over-expression Lysate for RSPH3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RSPH3 | | OriGene 3'-UTR Clone for RSPH3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RSPH3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RSPH3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RSPH3 | | OriGene Custom Protein Services for RSPH3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RSPH3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RSPH3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RSPH3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RSPH3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RSPH3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RSPH3 |
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| | | | Search Tocris compounds for RSPH3 |
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 | | | RSPH3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSPH3 |
|  |  |  | | | | ThermoFisher Antibodies for RSPH3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSPH3 |
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