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Aliases for RSPH14 Gene

Aliases for RSPH14 Gene

  • Radial Spoke Head 14 Homolog (Chlamydomonas) 2 3
  • RTDR1 3 4 6
  • Rhabdoid Tumor Deletion Region Protein 1 3 4
  • Rhabdoid Tumor Deletion Region Gene 1 2 3

External Ids for RSPH14 Gene

Previous Symbols for RSPH14 Gene

  • RTDR1

Summaries for RSPH14 Gene

Entrez Gene Summary for RSPH14 Gene

  • This gene encodes a protein with no known function but with slight similarity to a yeast vacuolar protein. The gene is located in a region deleted in pediatric rhabdoid tumors of the brain, kidney and soft tissues, but mutations in this gene have not been associated with the disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for RSPH14 Gene

RSPH14 (Radial Spoke Head 14 Homolog (Chlamydomonas)) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSPH14 Gene

Genomics for RSPH14 Gene

Genomic Location for RSPH14 Gene

Start:
23,059,415 bp from pter
End:
23,145,021 bp from pter
Size:
85,607 bases
Orientation:
Minus strand

Genomic View for RSPH14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RSPH14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSPH14 Gene

No data available for Regulatory Elements for RSPH14 Gene

Proteins for RSPH14 Gene

  • Protein details for RSPH14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHP6-RSP14_HUMAN
    Recommended name:
    Radial spoke head 14 homolog
    Protein Accession:
    Q9UHP6
    Secondary Accessions:

    Protein attributes for RSPH14 Gene

    Size:
    348 amino acids
    Molecular mass:
    38592 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RSPH14 Gene

Proteomics data for RSPH14 Gene at MOPED

Post-translational modifications for RSPH14 Gene

No Post-translational modifications

Other Protein References for RSPH14 Gene

No data available for DME Specific Peptides for RSPH14 Gene

Domains for RSPH14 Gene

Protein Domains for RSPH14 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

RSP14_HUMAN
Family:
  • Belongs to the flagellar radial spoke RSP14 family.:
    • Q9UHP6
Similarity:
  • Contains 8 ARM repeats.:
    • Q9UHP6
genes like me logo Genes that share domains with RSPH14: view

No data available for Gene Families for RSPH14 Gene

Function for RSPH14 Gene

Gene Ontology (GO) - Molecular Function for RSPH14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005488 binding --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RSPH14: view

Phenotypes for RSPH14 Gene

GenomeRNAi human phenotypes for RSPH14:
genes like me logo Genes that share phenotypes with RSPH14: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RSPH14 Gene

Localization for RSPH14 Gene

Gene Ontology (GO) - Cellular Components for RSPH14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with RSPH14: view

Pathways for RSPH14 Gene

SuperPathways for RSPH14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RSPH14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with RSPH14: view

No data available for Pathways by source for RSPH14 Gene

Transcripts for RSPH14 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for RSPH14 Gene

No ASD Table

Relevant External Links for RSPH14 Gene

GeneLoc Exon Structure for
RSPH14
ECgene alternative splicing isoforms for
RSPH14

Expression for RSPH14 Gene

mRNA expression in normal human tissues for RSPH14 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RSPH14 Gene

mRNA Expression by UniProt/SwissProt for RSPH14 Gene

Q9UHP6-RSP14_HUMAN
Tissue specificity: Expressed in adult cerebellum, spinal cord, spleen, skeletal muscle and some/5 out of 9 rhabdoid tumors. Detected in fetal brain, lung, liver and kidney.
genes like me logo Genes that share expressions with RSPH14: view

Orthologs for RSPH14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RSPH14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RTDR1 36
  • 99.04 (n)
  • 99.14 (a)
RTDR1 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RTDR1 36
  • 76.86 (n)
  • 66.47 (a)
RTDR1 37
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RTDR1 36
  • 75.98 (n)
  • 65.59 (a)
RTDR1 37
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rtdr1 36
  • 72.25 (n)
  • 64.41 (a)
Rtdr1 16
Rtdr1 37
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RTDR1 37
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RTDR1 37
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rtdr1 36
  • 74.47 (n)
  • 63.83 (a)
chicken
(Gallus gallus)
Aves RTDR1 36
  • 55.75 (n)
  • 46.31 (a)
RTDR1 37
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RTDR1 37
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rtdr1 36
  • 54.31 (n)
  • 48.24 (a)
Str.5058 36
zebrafish
(Danio rerio)
Actinopterygii rtdr1 36
  • 52.45 (n)
  • 46.18 (a)
rtdr1 37
  • 44 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 47 (a)
OneToOne
Species with no ortholog for RSPH14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RSPH14 Gene

ENSEMBL:
Gene Tree for RSPH14 (if available)
TreeFam:
Gene Tree for RSPH14 (if available)

Paralogs for RSPH14 Gene

Pseudogenes.org Pseudogenes for RSPH14 Gene

genes like me logo Genes that share paralogs with RSPH14: view

No data available for Paralogs for RSPH14 Gene

Variants for RSPH14 Gene

Sequence variations from dbSNP and Humsavar for RSPH14 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs756632 -- 23,127,731(+) GTAGA(C/T)CCCCA intron-variant
rs916583 -- 23,127,080(+) AGGGG(C/T)TTTAC intron-variant
rs916584 -- 23,127,246(+) ACCTC(A/G)CCCTG intron-variant
rs916585 -- 23,127,251(+) ACCCT(A/G)GATGA intron-variant
rs1987042 -- 23,135,457(-) tggag(C/T)gcagt intron-variant

Relevant External Links for RSPH14 Gene

HapMap Linkage Disequilibrium report
RSPH14

No data available for Structural Variations from Database of Genomic Variants (DGV) for RSPH14 Gene

Disorders for RSPH14 Gene

No disorders were found for RSPH14 Gene.

No data available for UniProtKB/Swiss-Prot for RSPH14 Gene

Publications for RSPH14 Gene

  1. Isolation of genes from the rhabdoid tumor deletion region in chromosome band 22q11.2. (PMID: 10607907) Zhou J.-Y. … Biegel J.A. (Gene 2000) 3 4 23
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. High-throughput mapping of a dynamic signaling network in mammalian cells. (PMID: 15761153) Barrios-Rodiles M. … Wrana J.L. (Science 2005) 3

Products for RSPH14 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RSPH14
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RSPH14
    • Block miRNA regulation of RSPH14 using miScript Target Protectors

    Sources for RSPH14 Gene

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