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Aliases for RSPH10B2 Gene

Aliases for RSPH10B2 Gene

  • Radial Spoke Head 10 Homolog B2 (Chlamydomonas) 2 3

External Ids for RSPH10B2 Gene

Previous GeneCards Identifiers for RSPH10B2 Gene

  • GC07P006761

Summaries for RSPH10B2 Gene

GeneCards Summary for RSPH10B2 Gene

RSPH10B2 (Radial Spoke Head 10 Homolog B2 (Chlamydomonas)) is a Protein Coding gene. An important paralog of this gene is RSPH1.

Gene Wiki entry for RSPH10B2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSPH10B2 Gene

Genomics for RSPH10B2 Gene

Regulatory Elements for RSPH10B2 Gene

Genomic Location for RSPH10B2 Gene

Chromosome:
7
Start:
6,754,108 bp from pter
End:
6,799,365 bp from pter
Size:
45,258 bases
Orientation:
Plus strand

Genomic View for RSPH10B2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RSPH10B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSPH10B2 Gene

Proteins for RSPH10B2 Gene

  • Protein details for RSPH10B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B2RC85-R10B2_HUMAN
    Recommended name:
    Radial spoke head 10 homolog B2
    Protein Accession:
    B2RC85
    Secondary Accessions:
    • A6NMW7
    • B2RXI4
    • B2RXJ0
    • Q86ST9
    • Q8NE68

    Protein attributes for RSPH10B2 Gene

    Size:
    870 amino acids
    Molecular mass:
    100547 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG37482.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RSPH10B2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RSPH10B2 Gene

Proteomics data for RSPH10B2 Gene at MOPED

Post-translational modifications for RSPH10B2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RSPH10B2 Gene

No data available for DME Specific Peptides for RSPH10B2 Gene

Domains & Families for RSPH10B2 Gene

Protein Domains for RSPH10B2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RSPH10B2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

B2RC85

UniProtKB/Swiss-Prot:

R10B2_HUMAN :
  • Contains 10 MORN repeats.
Similarity:
  • Contains 10 MORN repeats.
genes like me logo Genes that share domains with RSPH10B2: view

No data available for Gene Families for RSPH10B2 Gene

Function for RSPH10B2 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RSPH10B2 Gene

Localization for RSPH10B2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for RSPH10B2 Gene

Pathways & Interactions for RSPH10B2 Gene

SuperPathways for RSPH10B2 Gene

No Data Available

Interacting Proteins for RSPH10B2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000297186%0d%0a9606.ENSP00000340019%0d%0a9606.ENSP00000359988%0d%0a
Selected Interacting proteins: ENSP00000297186 for RSPH10B2 Gene via STRING

Gene Ontology (GO) - Biological Process for RSPH10B2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RSPH10B2 Gene

Drugs & Compounds for RSPH10B2 Gene

No Compound Related Data Available

Transcripts for RSPH10B2 Gene

mRNA/cDNA for RSPH10B2 Gene

(13) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RSPH10B2 Gene

Radial spoke head 10 homolog B2 (Chlamydomonas):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RSPH10B2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RSPH10B2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14
SP1: -
SP2: - -
SP3: -
SP4:
SP5: -

Relevant External Links for RSPH10B2 Gene

GeneLoc Exon Structure for
RSPH10B2
ECgene alternative splicing isoforms for
RSPH10B2

Expression for RSPH10B2 Gene

mRNA expression in normal human tissues for RSPH10B2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RSPH10B2 Gene

This gene is overexpressed in Testis (x26.2).

SOURCE GeneReport for Unigene cluster for RSPH10B2 Gene Hs.710326

genes like me logo Genes that share expression patterns with RSPH10B2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RSPH10B2 Gene

Orthologs for RSPH10B2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RSPH10B2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RSPH10B 35
  • 79.52 (n)
  • 74.56 (a)
-- 36
  • 74 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RSPH10B 35
  • 81.36 (n)
  • 76.4 (a)
-- 36
  • 76 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rsph10b 35
  • 76.42 (n)
  • 74.06 (a)
Rsph10b2 16
Rsph10b 36
  • 72 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC738574 35
  • 98.68 (n)
  • 97.79 (a)
-- 36
  • 98 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rsph10b 35
  • 76.84 (n)
  • 73.85 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 63 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves RSPH10B 35
  • 60.76 (n)
  • 52.08 (a)
-- 36
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rsph10b 35
  • 59.47 (n)
  • 52.56 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:153062 35
  • 56.75 (n)
  • 49.22 (a)
RSPH10B 36
  • 42 (a)
OneToMany
Species with no ortholog for RSPH10B2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RSPH10B2 Gene

ENSEMBL:
Gene Tree for RSPH10B2 (if available)
TreeFam:
Gene Tree for RSPH10B2 (if available)

Paralogs for RSPH10B2 Gene

Paralogs for RSPH10B2 Gene

(5) SIMAP similar genes for RSPH10B2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RSPH10B2: view

Variants for RSPH10B2 Gene

Sequence variations from dbSNP and Humsavar for RSPH10B2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs871042 -- 6,760,528(+) CACAC(A/G)TACAT intron-variant
rs1060836 -- 6,752,118(+) GCCCT(C/G)ATTCA upstream-variant-2KB
rs1180619 -- 6,754,201(+) CCTGC(C/G)TACGC intron-variant, utr-variant-5-prime, upstream-variant-2KB
rs1180623 -- 6,756,154(+) agtcc(C/T)agcta intron-variant
rs2003501 -- 6,771,902(+) TACTC(A/G)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RSPH10B2 Gene

Variant ID Type Subtype PubMed ID
nsv436904 CNV Insertion 17901297
nsv830892 CNV Loss 17160897
nsv830894 CNV Loss 17160897
nsv7392 OTHER Inversion 18451855
nsv8037 CNV Gain 18304495
esv2752174 CNV Gain 17911159
dgv7151n71 CNV Loss 21882294
nsv887441 CNV Gain 21882294
dgv7152n71 CNV Gain 21882294
dgv7153n71 CNV Gain 21882294
dgv2051e1 CNV Complex 17122850
dgv7154n71 CNV Gain 21882294
nsv887451 CNV Gain 21882294
esv33385 CNV Gain 17666407
nsv8040 CNV Gain 18304495
dgv7155n71 CNV Gain 21882294
dgv7156n71 CNV Gain 21882294
essv25135 CNV CNV 17122850

Variation tolerance for RSPH10B2 Gene

Gene Damage Index Score: 6.01; 74.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RSPH10B2 Gene

HapMap Linkage Disequilibrium report
RSPH10B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSPH10B2 Gene

Disorders for RSPH10B2 Gene

Relevant External Links for RSPH10B2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RSPH10B2
genes like me logo Genes that share disorders with RSPH10B2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RSPH10B2 Gene

Publications for RSPH10B2 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 67

Products for RSPH10B2 Gene

Sources for RSPH10B2 Gene

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