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RSPH10B2 Gene

protein-coding   GIFtS: 33
GCID: GC07P006793

Radial Spoke Head 10 Homolog B2 (Chlamydomonas)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Radial Spoke Head 10 Homolog B2 (Chlamydomonas)1 2
Radial Spoke Head 10 Homolog B2

External Ids:    HGNC: 343851   Entrez Gene: 7281942   Ensembl: ENSG000001694027   UniProtKB: B2RC853   

Export aliases for RSPH10B2 gene to outside databases

Previous GC identifer: GC07P006761


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RSPH10B2 Gene:
RSPH10B2 (radial spoke head 10 homolog B2 (Chlamydomonas)) is a protein-coding gene. An important paralog of this gene is RSPH10B.

Gene Wiki entry for RSPH10B2 (RSPH10B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the RSPH10B2 gene promoter:
         GR   Max1   AP-1   GR-beta   E4BP4   E47   COMP1   GR-alpha   c-Myc   Hlf   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for RSPH10B2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RSPH10B2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22.1

RSPH10B2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RSPH10B2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P006793:  view genomic region     (about GC identifiers)

Start:
6,793,740 bp from pter      End:
6,838,996 bp from pter
Size:
45,257 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 6,840,778-6,885,434     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: R10B2_HUMAN, B2RC85 (See protein sequence)
Recommended Name: Radial spoke head 10 homolog B2  
Size: 870 amino acids; 100547 Da
Sequence caution: Sequence=BAG37482.1; Type=Erroneous initiation;
Secondary accessions: A6NMW7 B2RXI4 B2RXJ0 Q86ST9 Q8NE68
Alternative splicing: 2 isoforms:  B2RC85-1   B2RC85-2   

Explore the universe of human proteins at neXtProt for RSPH10B2: NX_B2RC85

Explore proteomics data for RSPH10B2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RSPH10B2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001093167.1  
    ENSEMBL proteins: 
     ENSP00000384766   ENSP00000386102   ENSP00000396498   ENSP00000395335   ENSP00000445255  
     ENSP00000297186   ENSP00000416710   ENSP00000352749  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003409 MORN

    Graphical View of Domain Structure for InterPro Entry B2RC85

    ProtoNet protein and cluster: B2RC85

    UniProtKB/Swiss-Prot: R10B2_HUMAN, B2RC85
    Similarity: Contains 10 MORN repeats


    Find genes that share domains with RSPH10B2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RSPH10B2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1
    peroxisome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RSPH10B2
    Interactions:

        Search GeneGlobe Interaction Network for RSPH10B2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RSPH10B2 (R10B2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RSPH10B2 gene: 
    NM_001099697.1  

    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000403107(uc010ktk.1) ENST00000404077(uc003sqw.1) ENST00000435395
    ENST00000418406 ENST00000485129 ENST00000489190 ENST00000463354(uc011jxc.2)
    ENST00000497737 ENST00000485920(uc010ktl.2) ENST00000493745 ENST00000297186
    ENST00000433859 ENST00000359718
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      QuantiFast Probe-based Assays in human, mouse, rat RSPH10B2

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RSPH10B2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14
    SP1:                    -                                                                                                         
    SP2:                                      -                       -                                                               
    SP3:                                                                    -                                                         
    SP4:                                                                                                                              
    SP5:                                                                    -                                                         


    ECgene alternative splicing isoforms for RSPH10B2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RSPH10B2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RSPH10B2 Expression
    About this image


    RSPH10B2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Testis (Reproductive System)
    RSPH10B2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RSPH10B2 Protein Expression
        Custom PCR Arrays for RSPH10B2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSPH10B2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RSPH10B2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rsph10b25
    Rsph10b1
    radial spoke head 10 homolog B (Chlamydomonas)1, 5 76.42(n)1
    74.06(a)1
      5 (82.85 cM)5
    751361  XM_006504895.11  XP_006504958.11 
     1439330355 
    chicken
    (Gallus gallus)
    Aves RSPH10B1 radial spoke head 10 homolog B (Chlamydomonas) 60.76(n)
    52.08(a)
      100859701  XM_004945097.1  XP_004945154.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    59(a)
    49(a)
    many ↔ many
    many ↔ many
    GL343507.1(264039-267553)
    GL343507.1(276255-303184)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rsph10b1 radial spoke head 10 homolog B (Chlamydomonas) 59.47(n)
    52.56(a)
      779504  XM_004917978.1  XP_004918035.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1530621 zgc:153062 56.75(n)
    49.22(a)
      767792  NM_001076759.2  NP_001070227.1 


    ENSEMBL Gene Tree for RSPH10B2 (if available)
    TreeFam Gene Tree for RSPH10B2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RSPH10B2 gene
    RSPH10B1 2  MORN12  ALS2CL2  ALS22  RSPH12  MORN32  
    5 SIMAP similar genes for RSPH10B2 using alignment to 3 protein entries:     R10B2_HUMAN (see all proteins):
    RSPH10B    MORN2    MORN1    MORN4    LOC118812

    Find genes that share paralogs with RSPH10B2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RSPH10B2 (see all 367)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3760445561,2
    C--6792219(+) TGTGC-/GGCGTG 1 -- us2k10--------
    rs2010785101,2
    --6793111(+) ATGCC-/TGATGATC 1 -- us2k10--------
    rs2017088151,2
    C--6794229(+) GGAAGA/CGAGAA 1 -- int10--------
    rs1996778021,2
    --6794848(+) GCAAC-/TTCATGC 1 -- int10--------
    rs2006988451,2
    --6795501(+) GGTTG-/CAG   
       TGAGC
    CAGTG
    1 -- int10--------
    rs771110051,2
    C--6795769(+) GGTGGC/TGGGTG 1 -- int11Minor allele frequency- T:0.00NA 2
    rs1420144141,2
    C--6795785(+) AGTCCC/TAGCTA 1 -- int10--------
    rs2022397801,2
    --6795902(+) CTCAA-/AAAT  
            
    AAATA
    1 -- int10--------
    rs1477158191,2
    --6796300(+) GTGTGA/CGCCAC 1 -- int10--------
    rs1502643121,2
    C--6797510(+) AGAACA/GAAGAT 2 K E mis10--------

    HapMap Linkage Disequilibrium report for RSPH10B2 (6793740 - 6838996 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RSPH10B2 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436904CNV Insertion17901297
    nsv830892CNV Loss17160897
    nsv830894CNV Loss17160897
    dgv7151n71CNV Loss21882294
    nsv8037CNV Gain18304495
    dgv7152n71CNV Gain21882294
    dgv7156n71CNV Gain21882294
    dgv7154n71CNV Gain21882294
    dgv7153n71CNV Gain21882294
    nsv887451CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RSPH10B2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with RSPH10B2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 728194 HGNC: 34385 Ensembl:ENSG00000169402 euGenes: HUgn728194 ECgene: RSPH10B2
    H-InvDB: RSPH10B2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RSPH10B2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RSPH10B2 gene:
    Search GeneIP for patents involving RSPH10B2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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