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Aliases for RSPH10B Gene

Aliases for RSPH10B Gene

  • Radial Spoke Head 10 Homolog B 2 3
  • Radial Spoke Head 10 Homolog B (Chlamydomonas) 2 5

External Ids for RSPH10B Gene

Summaries for RSPH10B Gene

GeneCards Summary for RSPH10B Gene

RSPH10B (Radial Spoke Head 10 Homolog B) is a Protein Coding gene. An important paralog of this gene is RSPH1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSPH10B Gene

Genomics for RSPH10B Gene

Regulatory Elements for RSPH10B Gene

Promoters for RSPH10B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RSPH10B on UCSC Golden Path with GeneCards custom track

Genomic Location for RSPH10B Gene

Chromosome:
7
Start:
5,925,550 bp from pter
End:
5,970,684 bp from pter
Size:
45,135 bases
Orientation:
Minus strand

Genomic View for RSPH10B Gene

Genes around RSPH10B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RSPH10B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RSPH10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSPH10B Gene

Proteins for RSPH10B Gene

  • Protein details for RSPH10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C881-R10B1_HUMAN
    Recommended name:
    Radial spoke head 10 homolog B
    Protein Accession:
    P0C881
    Secondary Accessions:
    • A6NMW7
    • Q86ST9
    • Q8NE68

    Protein attributes for RSPH10B Gene

    Size:
    870 amino acids
    Molecular mass:
    100635 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RSPH10B Gene

Proteomics data for RSPH10B Gene at MOPED

Post-translational modifications for RSPH10B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RSPH10B Gene

No data available for DME Specific Peptides for RSPH10B Gene

Domains & Families for RSPH10B Gene

Protein Domains for RSPH10B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RSPH10B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C881

UniProtKB/Swiss-Prot:

R10B1_HUMAN :
  • Contains 10 MORN repeats.
Similarity:
  • Contains 10 MORN repeats.
genes like me logo Genes that share domains with RSPH10B: view

No data available for Gene Families for RSPH10B Gene

Function for RSPH10B Gene

Phenotypes for RSPH10B Gene

GenomeRNAi human phenotypes for RSPH10B:
genes like me logo Genes that share phenotypes with RSPH10B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RSPH10B Gene

Localization for RSPH10B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RSPH10B Gene COMPARTMENTS Subcellular localization image for RSPH10B gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RSPH10B Gene

Pathways & Interactions for RSPH10B Gene

SuperPathways for RSPH10B Gene

No Data Available

Interacting Proteins for RSPH10B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000338556%0d%0a9606.ENSP00000340019%0d%0a9606.ENSP00000359988%0d%0a
Selected Interacting proteins: ENSP00000338556 for RSPH10B Gene via STRING

Gene Ontology (GO) - Biological Process for RSPH10B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RSPH10B Gene

Drugs & Compounds for RSPH10B Gene

No Compound Related Data Available

Transcripts for RSPH10B Gene

Unigene Clusters for RSPH10B Gene

Radial spoke head 10 homolog B (Chlamydomonas):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RSPH10B Gene

No ASD Table

Relevant External Links for RSPH10B Gene

GeneLoc Exon Structure for
RSPH10B
ECgene alternative splicing isoforms for
RSPH10B

Expression for RSPH10B Gene

mRNA expression in normal human tissues for RSPH10B Gene

mRNA differential expression in normal tissues according to GTEx for RSPH10B Gene

This gene is overexpressed in Testis (x24.0).

SOURCE GeneReport for Unigene cluster for RSPH10B Gene Hs.442339

genes like me logo Genes that share expression patterns with RSPH10B: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RSPH10B Gene

Orthologs for RSPH10B Gene

This gene was present in the common ancestor of chordates.

Orthologs for RSPH10B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RSPH10B 35
  • 79.6 (n)
  • 74.79 (a)
-- 36
  • 74 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RSPH10B 35
  • 81.43 (n)
  • 76.63 (a)
-- 36
  • 76 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rsph10b 35
  • 76.49 (n)
  • 74.17 (a)
Rsph10b 36
  • 72 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC738574 35
  • 98.74 (n)
  • 98.05 (a)
-- 36
  • 98 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rsph10b 35
  • 76.91 (n)
  • 73.97 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 63 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves RSPH10B 35
  • 60.81 (n)
  • 52.08 (a)
-- 36
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rsph10b 35
  • 59.42 (n)
  • 52.41 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:153062 35
  • 56.75 (n)
  • 49.22 (a)
RSPH10B 36
  • 42 (a)
OneToMany
Species with no ortholog for RSPH10B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RSPH10B Gene

ENSEMBL:
Gene Tree for RSPH10B (if available)
TreeFam:
Gene Tree for RSPH10B (if available)

Paralogs for RSPH10B Gene

Paralogs for RSPH10B Gene

(4) SIMAP similar genes for RSPH10B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RSPH10B: view

Variants for RSPH10B Gene

Sequence variations from dbSNP and Humsavar for RSPH10B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs737545 -- 5,934,858(+) TATTA(C/T)TGCTG intron-variant
rs870415 -- 5,963,493(+) CGTTA(C/T)GCGCA intron-variant
rs871040 -- 5,964,492(-) GGCAT(A/G)TAACC intron-variant
rs871041 -- 5,964,271(-) GAGCA(C/T)ACGTA intron-variant
rs1007157 -- 5,932,092(+) AGCGG(A/G)AAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RSPH10B Gene

Variant ID Type Subtype PubMed ID
nsv436904 CNV Insertion 17901297
nsv830892 CNV Loss 17160897
nsv830894 CNV Loss 17160897
nsv7392 OTHER Inversion 18451855
nsv8037 CNV Gain 18304495
esv2752174 CNV Gain 17911159
dgv7151n71 CNV Loss 21882294
nsv887441 CNV Gain 21882294
dgv7152n71 CNV Gain 21882294
dgv7153n71 CNV Gain 21882294
dgv2051e1 CNV Complex 17122850
dgv7154n71 CNV Gain 21882294
nsv887451 CNV Gain 21882294
esv33385 CNV Gain 17666407
nsv8040 CNV Gain 18304495
dgv7155n71 CNV Gain 21882294
dgv7156n71 CNV Gain 21882294
essv25135 CNV CNV 17122850

Variation tolerance for RSPH10B Gene

Gene Damage Index Score: 5.23; 70.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RSPH10B Gene

HapMap Linkage Disequilibrium report
RSPH10B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSPH10B Gene

Disorders for RSPH10B Gene

Relevant External Links for RSPH10B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RSPH10B

No disorders were found for RSPH10B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RSPH10B Gene

Publications for RSPH10B Gene

  1. Radial spoke proteins of Chlamydomonas flagella. (PMID: 16507594) Yang P. … Witman G.B. (J. Cell. Sci. 2006) 2 3 67
  2. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for RSPH10B Gene

Sources for RSPH10B Gene

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