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RSPH10B Gene

protein-coding   GIFtS: 38
GCID: GC07M005935

Radial Spoke Head 10 Homolog B (Chlamydomonas)

  Search for RSPH10B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Radial Spoke Head 10 Homolog B (Chlamydomonas)1 2
Radial Spoke Head 10 Homolog B2
Radial Spoke Head 10 Homolog B22

External Ids:    HGNC: 273621   Entrez Gene: 2229672   Ensembl: ENSG000001550267   UniProtKB: P0C8813   

Export aliases for RSPH10B gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RSPH10B Gene:
RSPH10B (radial spoke head 10 homolog B (Chlamydomonas)) is a protein-coding gene. An important paralog of this gene is RSPH10B2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RSPH10B gene promoter:
         GR   Max1   AP-1   GR-beta   E4BP4   E47   COMP1   GR-alpha   c-Myc   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): RSPH10B promoter sequence
   Search Chromatin IP Primers for RSPH10B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RSPH10B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22.2

RSPH10B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RSPH10B gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M005935:  view genomic region     (about GC identifiers)

Start:
5,965,181 bp from pter      End:
6,010,314 bp from pter
Size:
45,134 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 6,012,122-6,056,659     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: R10B1_HUMAN, P0C881 (See protein sequence)
Recommended Name: Radial spoke head 10 homolog B  
Size: 870 amino acids; 100635 Da
Secondary accessions: A6NMW7 Q86ST9 Q8NE68

Explore the universe of human proteins at neXtProt for RSPH10B: NX_P0C881

Explore proteomics data for RSPH10B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RSPH10B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775836.3  
    ENSEMBL proteins: 
     ENSP00000385443   ENSP00000384097   ENSP00000444512   ENSP00000390326   ENSP00000338556  
     ENSP00000400988   ENSP00000445203  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003409 MORN

    Graphical View of Domain Structure for InterPro Entry P0C881

    ProtoNet protein and cluster: P0C881

    UniProtKB/Swiss-Prot: R10B1_HUMAN, P0C881
    Similarity: Contains 10 MORN repeats


    RSPH10B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RSPH10B
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1
    peroxisome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RSPH10B
    Interactions:

        Search GeneGlobe Interaction Network for RSPH10B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RSPH10B (R10B1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RSPH10B gene: 
    NM_173565.3  

    Unigene Cluster for RSPH10B:

    Radial spoke head 10 homolog B (Chlamydomonas)
    Hs.442339  [show with all ESTs]
    Unigene Representative Sequence: BC034495
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000405415(uc010ktd.1) ENST00000404406(uc003sph.1) ENST00000535104(uc011jwk.2)
    ENST00000541997 ENST00000477641 ENST00000539630 ENST00000542644 ENST00000455618
    ENST00000337579(uc003spg.1) ENST00000441023 ENST00000539903
    miRNA
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    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat RSPH10B

    Additional mRNA sequence: 

    BC034495.1 BC157864.1 BC157871.1 

    7 DOTS entries:

    DT.95258690  DT.121095965  DT.95255883  DT.121096044  DT.97809241  DT.121128032  DT.121128023 

    16 AceView cDNA sequences:

    AK093411 CB241675 BI460936 BC034495 AA844689 AX748110 AA382672 BG722304 
    AW474289 NM_173565 AA383246 AW872691 AA868223 BG717722 AA021610 AA021177 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RSPH10B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGATTAC
    RSPH10B Expression
    About this image

    RSPH10B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RSPH10B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.442339
        Custom PCR Arrays for RSPH10B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSPH10B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RSPH10B gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rsph10b1 radial spoke head 10 homolog B (Chlamydomonas) 76.49(n)
    74.17(a)
      75136  XM_006504895.1  XP_006504958.1 
    chicken
    (Gallus gallus)
    Aves RSPH10B1 radial spoke head 10 homolog B (Chlamydomonas) 60.81(n)
    52.08(a)
      100859701  XM_004945097.1  XP_004945154.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    59(a)
    49(a)
    many ↔ many
    many ↔ many
    GL343507.1(264039-267553)
    GL343507.1(276255-303184)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rsph10b1 radial spoke head 10 homolog B (Chlamydomonas) 59.42(n)
    52.41(a)
      779504  XM_004917978.1  XP_004918035.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1530621 zgc:153062 56.75(n)
    49.22(a)
      767792  NM_001076759.2  NP_001070227.1 


    ENSEMBL Gene Tree for RSPH10B (if available)
    TreeFam Gene Tree for RSPH10B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RSPH10B gene
    RSPH10B21 2  MORN12  ALS2CL2  ALS22  RSPH12  MORN32  
    4 SIMAP similar genes for RSPH10B using alignment to 2 protein entries:     R10B1_HUMAN (see all proteins):
    RSPH10B2    MORN2    LOC118812    MORN4

    RSPH10B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RSPH10B (see all 423)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1396189071,2
    F--5966121(+) TGTGAT/CGTCCA 2 /I /V mis11Minor allele frequency- C:0.00NA 4524
    rs2014020521,2
    C--5966127(+) GTCCAC/TCTCAT 2 M V mis11Minor allele frequency- T:0.00EU 1321
    rs2020327331,2
    C--5966130(+) CACCTC/TATAGT 2 K E mis11Minor allele frequency- T:0.00EU 1321
    rs2005278831,2
    C,F--5966192(+) CAAACA/GTGAGA 1 -- int11Minor allele frequency- G:0.00EU 1317
    rs1995178581,2
    C--5966345(+) CATGTC/TGACAC 1 -- int10--------
    rs2009606981,2
    C--5966367(+) AACTTC/TTCATC 1 -- int10--------
    rs2018057241,2
    C--5966379(+) ATCTAC/TGAAAA 1 -- int10--------
    rs679585181,2
    C--5966407(+) AGACA-/AGAGTT 1 -- int10--------
    rs710083391,2
    C--5966561(-) CTACTA/-AAAAA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs624536361,2
    C--5966676(+) TGTGTA/GTATTA 1 -- int10--------

    HapMap Linkage Disequilibrium report for RSPH10B (5965181 - 6010314 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RSPH10B (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436904CNV Insertion17901297
    nsv830892CNV Loss17160897
    nsv830894CNV Loss17160897
    dgv7151n71CNV Loss21882294
    nsv8037CNV Gain18304495
    dgv7152n71CNV Gain21882294
    dgv7156n71CNV Gain21882294
    dgv7154n71CNV Gain21882294
    dgv7153n71CNV Gain21882294
    nsv887451CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RSPH10B
    DNA2.0 Custom Variant and Variant Library Synthesis for RSPH10B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RSPH10B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with RSPH10B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Radial spoke proteins of Chlamydomonas flagella. (PubMed id 16507594)1, 3 Yang P....Witman G.B. (J. Cell. Sci. 2006)
    2. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 222967 HGNC: 27362 AceView: LOC222967 Ensembl:ENSG00000155026 euGenes: HUgn222967
    ECgene: RSPH10B H-InvDB: RSPH10B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RSPH10B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RSPH10B gene:
    Search GeneIP for patents involving RSPH10B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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