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Aliases for RSPH10B Gene

Aliases for RSPH10B Gene

  • Radial Spoke Head 10 Homolog B 2 3 5
  • Radial Spoke Head 10 Homolog B (Chlamydomonas) 2

External Ids for RSPH10B Gene

Summaries for RSPH10B Gene

GeneCards Summary for RSPH10B Gene

RSPH10B (Radial Spoke Head 10 Homolog B) is a Protein Coding gene. An important paralog of this gene is RSPH10B2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSPH10B Gene

Genomics for RSPH10B Gene

Regulatory Elements for RSPH10B Gene

Enhancers for RSPH10B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F006007 1.2 ENCODE 6.2 -39.9 -39943 6.3 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 EIF2AK1 PMS2 ANKRD61 PMS2CL CCZ1 RSPH10B ZDHHC4 AIMP2 ENSG00000207217
GH07F006014 1.3 Ensembl ENCODE 5.7 -45.7 -45710 3.1 PKNOX1 ARNT SIN3A ARID4B DMAP1 ZNF766 FOS KLF13 JUNB MEF2D EIF2AK1 PMS2 PMS2CL ENSG00000198580 ZNF316 CCZ1 RSPH10B ZDHHC4 ENSG00000207217 AIMP2
GH07F005995 1.2 Ensembl ENCODE 6 -25.1 -25101 1.5 PKNOX1 SIN3A FEZF1 GTF3C2 KLF7 FOS SP3 ZHX2 TSHZ1 ZNF518A ANKRD61 ZNF316 C7orf26 USP42 EIF2AK1 KDELR2 PMS2CL PMS2 RSPH10B CCZ1
GH07F006103 1.5 FANTOM5 ENCODE 4.7 -134.8 -134751 3.8 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 EIF2AK1 KDELR2 C7orf26 ZNF316 RNU6-218P USP42 PMS2 CCZ1 RSPH10B GC07M006104
GH07F006019 1.1 ENCODE 5.9 -49.3 -49337 1.0 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF143 ZNF207 KLF13 EIF2AK1 RSPH10B CCZ1 ENSG00000207217 ANKRD61
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RSPH10B on UCSC Golden Path with GeneCards custom track

Promoters for RSPH10B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001888860 84 401 ZNF664 HDAC2 ADNP CUX1 REST KDM1A

Genomic Location for RSPH10B Gene

5,925,550 bp from pter
5,970,684 bp from pter
45,135 bases
Minus strand

Genomic View for RSPH10B Gene

Genes around RSPH10B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RSPH10B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RSPH10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSPH10B Gene

Proteins for RSPH10B Gene

  • Protein details for RSPH10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Radial spoke head 10 homolog B
    Protein Accession:
    Secondary Accessions:
    • A6NMW7
    • Q86ST9
    • Q8NE68

    Protein attributes for RSPH10B Gene

    870 amino acids
    Molecular mass:
    100635 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RSPH10B Gene

Post-translational modifications for RSPH10B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RSPH10B Gene

Domains & Families for RSPH10B Gene

Protein Domains for RSPH10B Gene


Suggested Antigen Peptide Sequences for RSPH10B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 10 MORN repeats.
  • Contains 10 MORN repeats.
genes like me logo Genes that share domains with RSPH10B: view

No data available for Gene Families for RSPH10B Gene

Function for RSPH10B Gene

Phenotypes for RSPH10B Gene

GenomeRNAi human phenotypes for RSPH10B:
genes like me logo Genes that share phenotypes with RSPH10B: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RSPH10B Gene

Localization for RSPH10B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RSPH10B gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RSPH10B Gene

Pathways & Interactions for RSPH10B Gene

SuperPathways for RSPH10B Gene

No Data Available

Interacting Proteins for RSPH10B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000338556 for RSPH10B Gene via STRING

Gene Ontology (GO) - Biological Process for RSPH10B Gene


No data available for Pathways by source and SIGNOR curated interactions for RSPH10B Gene

Transcripts for RSPH10B Gene

Unigene Clusters for RSPH10B Gene

Radial spoke head 10 homolog B (Chlamydomonas):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RSPH10B Gene

No ASD Table

Relevant External Links for RSPH10B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RSPH10B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RSPH10B Gene

mRNA differential expression in normal tissues according to GTEx for RSPH10B Gene

This gene is overexpressed in Testis (x24.0).

NURSA nuclear receptor signaling pathways regulating expression of RSPH10B Gene:


SOURCE GeneReport for Unigene cluster for RSPH10B Gene:

genes like me logo Genes that share expression patterns with RSPH10B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RSPH10B Gene

Orthologs for RSPH10B Gene

This gene was present in the common ancestor of chordates.

Orthologs for RSPH10B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC738574 34
  • 98.74 (n)
-- 35
  • 98 (a)
(Canis familiaris)
Mammalia RSPH10B 34
  • 81.43 (n)
-- 35
  • 76 (a)
(Bos Taurus)
Mammalia RSPH10B 34
  • 79.6 (n)
-- 35
  • 74 (a)
(Rattus norvegicus)
Mammalia Rsph10b 34
  • 76.91 (n)
(Mus musculus)
Mammalia Rsph10b 34 35
  • 76.49 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 67 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 63 (a)
(Gallus gallus)
Aves RSPH10B 34
  • 60.81 (n)
-- 35
  • 46 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 59 (a)
-- 35
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rsph10b 34
  • 59.42 (n)
(Danio rerio)
Actinopterygii zgc:153062 34
  • 56.75 (n)
RSPH10B 35
  • 42 (a)
Species where no ortholog for RSPH10B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RSPH10B Gene

Gene Tree for RSPH10B (if available)
Gene Tree for RSPH10B (if available)

Paralogs for RSPH10B Gene

Paralogs for RSPH10B Gene

(4) SIMAP similar genes for RSPH10B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RSPH10B: view

Variants for RSPH10B Gene

Sequence variations from dbSNP and Humsavar for RSPH10B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1007157 -- 5,932,092(+) AGCGG(A/G)AAATT intron-variant
rs1007158 -- 5,933,835(+) ttttg(A/G)gacgg intron-variant
rs1061428 -- 5,925,657(+) GCAAC(A/G)CAGTT intron-variant, nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon
rs10616078 -- 5,942,934(+) TTTTT(-/TT)AAGAC intron-variant, downstream-variant-500B
rs111352726 -- 5,927,221(+) AGTAG(A/C)TGGGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RSPH10B Gene

Variant ID Type Subtype PubMed ID
dgv6243n100 CNV loss 25217958
dgv6241n100 CNV gain 25217958
dgv1867e212 CNV loss 25503493
dgv1866e212 CNV loss 25503493
dgv1865e212 CNV loss 25503493
dgv1864e212 CNV loss 25503493
nsv970789 CNV duplication 23825009
nsv966754 CNV duplication 23825009
nsv830894 CNV loss 17160897
nsv830892 CNV loss 17160897
nsv8040 CNV gain 18304495
nsv8037 CNV gain 18304495
nsv7392 OTHER inversion 18451855
nsv436904 CNV insertion 17901297
nsv1153955 CNV duplication 26484159
nsv1147398 CNV duplication 26484159
nsv1141527 CNV duplication 24896259
nsv1077484 CNV duplication 25765185
nsv1074069 CNV deletion 25765185
nsv1034916 CNV gain 25217958
nsv1017061 CNV loss 25217958
esv3571605 CNV loss 25503493
esv3571591 CNV loss 25503493
esv33385 CNV gain 17666407
esv2762647 CNV gain 21179565
esv2759504 CNV loss 17122850
esv2752174 CNV gain 17911159

Variation tolerance for RSPH10B Gene

Gene Damage Index Score: 5.23; 70.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RSPH10B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSPH10B Gene

Disorders for RSPH10B Gene

Relevant External Links for RSPH10B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RSPH10B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RSPH10B Gene

Publications for RSPH10B Gene

  1. Radial spoke proteins of Chlamydomonas flagella. (PMID: 16507594) Yang P. … Witman G.B. (J. Cell. Sci. 2006) 2 3 64
  2. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 4 64

Products for RSPH10B Gene

Sources for RSPH10B Gene

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