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Aliases for RSL24D1 Gene

Aliases for RSL24D1 Gene

  • Ribosomal L24 Domain Containing 1 2 3
  • Ribosomal L24 Domain-Containing Protein 1 3 4
  • C15orf15 3 4
  • RPL24L 3 4
  • Homolog Of Yeast Ribosomal Like Protein 24 3
  • Chromosome 15 Open Reading Frame 15 2
  • 60S Ribosomal Protein L30 Isolog 3
  • Ribosomal Protein L24-Like 4
  • My024 Protein 3
  • HRP-L30-Iso 3
  • RLP24 3
  • RPL24 3
  • TVAS3 3
  • L30 3

External Ids for RSL24D1 Gene

Previous HGNC Symbols for RSL24D1 Gene

  • C15orf15

Previous GeneCards Identifiers for RSL24D1 Gene

  • GC15M053261
  • GC15M055473
  • GC15M032299

Summaries for RSL24D1 Gene

Entrez Gene Summary for RSL24D1 Gene

  • This gene encodes a protein sharing a low level of sequence similarity with human ribosomal protein L24. Although this gene has been referred to as RPL24, L30, and 60S ribosomal protein L30 isolog in the sequence databases, it is distinct from the human genes officially named RPL24 (which itself has been referred to as ribosomal protein L30) and RPL30. The protein encoded by this gene localizes to the nucleolus and is thought to play a role in the biogenesis of the 60S ribosomal subunit. The precise function of this gene is currently unknown. This gene utilizes alternative polyadenylation signals and has multiple pseudogenes. [provided by RefSeq, Jul 2012]

GeneCards Summary for RSL24D1 Gene

RSL24D1 (Ribosomal L24 Domain Containing 1) is a Protein Coding gene. Diseases associated with RSL24D1 include diamond-blackfan anemia. Among its related pathways are Infectious disease and Transport to the Golgi and subsequent modification. GO annotations related to this gene include structural constituent of ribosome.

UniProtKB/Swiss-Prot for RSL24D1 Gene

  • Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity).

Gene Wiki entry for RSL24D1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSL24D1 Gene

Genomics for RSL24D1 Gene

Regulatory Elements for RSL24D1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RSL24D1 Gene

Chromosome:
15
Start:
55,180,806 bp from pter
End:
55,197,067 bp from pter
Size:
16,262 bases
Orientation:
Minus strand

Genomic View for RSL24D1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for RSL24D1 Gene

Proteins for RSL24D1 Gene

  • Protein details for RSL24D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHA3-RLP24_HUMAN
    Recommended name:
    Probable ribosome biogenesis protein RLP24
    Protein Accession:
    Q9UHA3
    Secondary Accessions:
    • B2RD72
    • Q561V8
    • Q8N6S8
    • Q96B04
    • Q96C76
    • Q96HJ1

    Protein attributes for RSL24D1 Gene

    Size:
    163 amino acids
    Molecular mass:
    19621 Da
    Quaternary structure:
    • Associated with nucleolar and cytoplasmic pre-60S particles. At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homolog, RPL24 (By similarity).

neXtProt entry for RSL24D1 Gene

Proteomics data for RSL24D1 Gene at MOPED

Post-translational modifications for RSL24D1 Gene

  • Ubiquitination at Lys 27, Lys 73, and Lys 88
  • Modification sites at PhosphoSitePlus

Other Protein References for RSL24D1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RSL24D1 Gene

Domains & Families for RSL24D1 Gene

Suggested Antigen Peptide Sequences for RSL24D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UHA3

UniProtKB/Swiss-Prot:

RLP24_HUMAN :
  • Belongs to the ribosomal protein L24e family.
Family:
  • Belongs to the ribosomal protein L24e family.
genes like me logo Genes that share domains with RSL24D1: view

No data available for Gene Families for RSL24D1 Gene

Function for RSL24D1 Gene

Molecular function for RSL24D1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity).

Gene Ontology (GO) - Molecular Function for RSL24D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IBA --
GO:0005515 protein binding IPI 16189514
GO:0044822 poly(A) RNA binding IBA --
genes like me logo Genes that share ontologies with RSL24D1: view
genes like me logo Genes that share phenotypes with RSL24D1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RSL24D1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RSL24D1 Gene

Localization for RSL24D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RSL24D1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RSL24D1 Gene COMPARTMENTS Subcellular localization image for RSL24D1 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for RSL24D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005840 ribosome --
GO:0022625 cytosolic large ribosomal subunit IBA --
genes like me logo Genes that share ontologies with RSL24D1: view

Pathways & Interactions for RSL24D1 Gene

genes like me logo Genes that share pathways with RSL24D1: view

Pathways by source for RSL24D1 Gene

1 BioSystems pathway for RSL24D1 Gene
1 KEGG pathway for RSL24D1 Gene
1 GeneGo (Thomson Reuters) pathway for RSL24D1 Gene

Gene Ontology (GO) - Biological Process for RSL24D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0006412 translation IBA --
GO:1902626 assembly of large subunit precursor of preribosome IBA --
genes like me logo Genes that share ontologies with RSL24D1: view

No data available for SIGNOR curated interactions for RSL24D1 Gene

Drugs & Compounds for RSL24D1 Gene

(3) Drugs for RSL24D1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
anisomycin Experimental Pharma Target JNK, SAPK and p38 activator 0
puromycin Experimental Pharma Target 0
genes like me logo Genes that share compounds with RSL24D1: view

Transcripts for RSL24D1 Gene

Unigene Clusters for RSL24D1 Gene

Ribosomal L24 domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RSL24D1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RSL24D1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: -
SP3: -

Relevant External Links for RSL24D1 Gene

GeneLoc Exon Structure for
RSL24D1
ECgene alternative splicing isoforms for
RSL24D1

Expression for RSL24D1 Gene

mRNA expression in normal human tissues for RSL24D1 Gene

Protein differential expression in normal tissues from HIPED for RSL24D1 Gene

This gene is overexpressed in Lung (52.8) and Pancreas (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RSL24D1 Gene



SOURCE GeneReport for Unigene cluster for RSL24D1 Gene Hs.274772

genes like me logo Genes that share expression patterns with RSL24D1: view

Protein tissue co-expression partners for RSL24D1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RSL24D1 Gene

Orthologs for RSL24D1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RSL24D1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RSL24D1 35
  • 90.95 (n)
  • 96.91 (a)
RSL24D1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RSL24D1 35
  • 92.96 (n)
  • 98.76 (a)
RSL24D1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rsl24d1 35
  • 87.86 (n)
  • 98.77 (a)
Rsl24d1 16
Rsl24d1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RSL24D1 35
  • 99.59 (n)
  • 100 (a)
RSL24D1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rsl24d1 35
  • 87.86 (n)
  • 98.15 (a)
oppossum
(Monodelphis domestica)
Mammalia RSL24D1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RSL24D1 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC768911 35
  • 80.95 (n)
  • 90.68 (a)
lizard
(Anolis carolinensis)
Reptilia RSL24D1 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rsl24d1 35
  • 79.63 (n)
  • 88.27 (a)
zebrafish
(Danio rerio)
Actinopterygii rsl24d1 35
  • 74.95 (n)
  • 79.5 (a)
wufa95d02 35
rsl24d1 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001545 35
  • 58.02 (n)
  • 59.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL24-like 35
  • 58.49 (n)
  • 60.38 (a)
RpL24-like 36
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rpl-24.2 35
  • 57.68 (n)
  • 55.32 (a)
rpl-24.2 36
  • 48 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR346W 35
  • 56.31 (n)
  • 54.04 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E09439g 35
  • 54.45 (n)
  • 54.04 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RLP24 35
  • 58.02 (n)
  • 60.74 (a)
RLP24 36
  • 43 (a)
OneToOne
RLP24 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G44860 35
  • 59.91 (n)
  • 60.14 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3722 35
rice
(Oryza sativa)
Liliopsida Os.2120 35
Os01g0514000 35
  • 55.28 (n)
  • 49.07 (a)
corn
(Zea mays)
Liliopsida Zm.7161 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05235 35
  • 51.47 (n)
  • 47.79 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8868 36
  • 57 (a)
OneToOne
Species with no ortholog for RSL24D1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RSL24D1 Gene

ENSEMBL:
Gene Tree for RSL24D1 (if available)
TreeFam:
Gene Tree for RSL24D1 (if available)

Paralogs for RSL24D1 Gene

(1) SIMAP similar genes for RSL24D1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RSL24D1: view

No data available for Paralogs for RSL24D1 Gene

Variants for RSL24D1 Gene

Sequence variations from dbSNP and Humsavar for RSL24D1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs10438 -- 55,181,607(+) CAGAA(G/T)GGTTA utr-variant-3-prime
rs3759861 -- 55,180,994(+) AGGGA(C/T)TGGTC downstream-variant-500B
rs3759862 -- 55,190,906(+) ACTGA(A/C)ACTTA intron-variant
rs6493768 -- 55,192,096(+) GTCAT(A/T)GGTTT intron-variant
rs7163785 -- 55,190,222(+) cagcc(A/G)gtggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RSL24D1 Gene

Variant ID Type Subtype PubMed ID
nsv525768 CNV Loss 19592680

Variation tolerance for RSL24D1 Gene

Residual Variation Intolerance Score: 64.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RSL24D1 Gene

HapMap Linkage Disequilibrium report
RSL24D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSL24D1 Gene

Disorders for RSL24D1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RSL24D1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia
  • chronic constitutional pure red cell anaemia
- elite association

Relevant External Links for RSL24D1

Genetic Association Database (GAD)
RSL24D1
Human Genome Epidemiology (HuGE) Navigator
RSL24D1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RSL24D1
genes like me logo Genes that share disorders with RSL24D1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RSL24D1 Gene

Publications for RSL24D1 Gene

  1. Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia. (PMID: 20116044) Doherty L. … Gazda H.T. (Am. J. Hum. Genet. 2010) 23 67
  2. Sequential protein association with nascent 60S ribosomal particles. (PMID: 12808088) Saveanu C. … Fromont-Racine M. (Mol. Cell. Biol. 2003) 2 67
  3. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PMID: 12962325) Odintsova T.I. … Karpova G.G. (J. Protein Chem. 2003) 23 67
  4. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 23 67
  5. Nog2p, a putative GTPase associated with pre-60S subunits and required for late 60S maturation steps. (PMID: 11707418) Saveanu C. … Fromont-Racine M. (EMBO J. 2001) 2 67

Products for RSL24D1 Gene

Sources for RSL24D1 Gene

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