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Aliases for RSL1D1 Gene

Aliases for RSL1D1 Gene

  • Ribosomal L1 Domain Containing 1 2 3
  • Cellular Senescence-Inhibited Gene Protein 3 4
  • CATX-11 3 4
  • CSIG 3 4
  • PBK1 3 4
  • Cellular Senescence Inhibited Gene Protein 3
  • Ribosomal L1 Domain-Containing Protein 1 3
  • Protein PBK1 4
  • CATX11 4
  • UTP30 3
  • L12 3

External Ids for RSL1D1 Gene

Previous GeneCards Identifiers for RSL1D1 Gene

  • GC16M011839
  • GC16M011929
  • GC16M011844
  • GC16M011930
  • GC16M011931
  • GC16M011933
  • GC16M011934

Summaries for RSL1D1 Gene

GeneCards Summary for RSL1D1 Gene

RSL1D1 (Ribosomal L1 Domain Containing 1) is a Protein Coding gene. Among its related pathways are Senescence and Autophagy. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RSL1D1 Gene

  • Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.

Gene Wiki entry for RSL1D1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSL1D1 Gene

Genomics for RSL1D1 Gene

Regulatory Elements for RSL1D1 Gene

Genomic Location for RSL1D1 Gene

Start:
11,833,850 bp from pter
End:
11,851,585 bp from pter
Size:
17,736 bases
Orientation:
Minus strand

Genomic View for RSL1D1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RSL1D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSL1D1 Gene

Proteins for RSL1D1 Gene

  • Protein details for RSL1D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76021-RL1D1_HUMAN
    Recommended name:
    Ribosomal L1 domain-containing protein 1
    Protein Accession:
    O76021
    Secondary Accessions:
    • B4DJ58
    • D3DUG7
    • Q2M1T7
    • Q6PL22
    • Q8IWS7
    • Q8WUZ1
    • Q9HDA9
    • Q9Y3Z9

    Protein attributes for RSL1D1 Gene

    Size:
    490 amino acids
    Molecular mass:
    54973 Da
    Quaternary structure:
    • Interacts with ING1 (isoform 2).
    SequenceCaution:
    • Sequence=AAF98239.1; Type=Frameshift; Positions=394; Evidence={ECO:0000305}; Sequence=AAH19069.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA07491.1; Type=Frameshift; Positions=486; Evidence={ECO:0000305};

    Alternative splice isoforms for RSL1D1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RSL1D1 Gene

Proteomics data for RSL1D1 Gene at MOPED

Post-translational modifications for RSL1D1 Gene

  • Ubiquitination at Lys188
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RSL1D1 Gene

Domains for RSL1D1 Gene

Protein Domains for RSL1D1 Gene

Graphical View of Domain Structure for InterPro Entry

O76021

UniProtKB/Swiss-Prot:

RL1D1_HUMAN :
  • O76021
Family:
  • Belongs to the ribosomal protein L1P family. Highly divergent.
genes like me logo Genes that share domains with RSL1D1: view

No data available for Gene Families for RSL1D1 Gene

Function for RSL1D1 Gene

Molecular function for RSL1D1 Gene

UniProtKB/Swiss-Prot Function: Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.
UniProtKB/Swiss-Prot Induction: Down-regulated during cellular senescence.

Gene Ontology (GO) - Molecular Function for RSL1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0005515 protein binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RSL1D1: view

Phenotypes for RSL1D1 Gene

genes like me logo Genes that share phenotypes with RSL1D1: view

miRNA for RSL1D1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RSL1D1 Gene

Localization for RSL1D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RSL1D1 Gene

Nucleus, nucleolus. Note=Colocalizes with ING1 in the nucleolus after UV stress. {ECO:0000269 PubMed:22419112}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RSL1D1 Gene COMPARTMENTS Subcellular localization image for RSL1D1 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for RSL1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0016020 membrane IDA 16210410
genes like me logo Genes that share ontologies with RSL1D1: view

Pathways for RSL1D1 Gene

SuperPathways for RSL1D1 Gene

Superpath Contained pathways
1 Senescence and Autophagy
genes like me logo Genes that share pathways with RSL1D1: view

Pathways by source for RSL1D1 Gene

1 BioSystems pathway for RSL1D1 Gene

Gene Ontology (GO) - Biological Process for RSL1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
GO:0032880 regulation of protein localization IMP 17158916
GO:0042981 regulation of apoptotic process IDA 18678645
GO:2000772 regulation of cellular senescence IDA 18678645
genes like me logo Genes that share ontologies with RSL1D1: view

Transcripts for RSL1D1 Gene

mRNA/cDNA for RSL1D1 Gene

Unigene Clusters for RSL1D1 Gene

Ribosomal L1 domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RSL1D1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1: - -
SP2: - - - - - - -
SP3:
SP4:

Relevant External Links for RSL1D1 Gene

GeneLoc Exon Structure for
RSL1D1
ECgene alternative splicing isoforms for
RSL1D1

Expression for RSL1D1 Gene

mRNA expression in normal human tissues for RSL1D1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RSL1D1 Gene

SOURCE GeneReport for Unigene cluster for RSL1D1 Gene Hs.401842

mRNA Expression by UniProt/SwissProt for RSL1D1 Gene

O76021-RL1D1_HUMAN
Tissue specificity: Expressed at high intensities in the heart, skeletal muscle, and placenta.
genes like me logo Genes that share expressions with RSL1D1: view

No data available for mRNA differential expression in normal tissues for RSL1D1 Gene

Orthologs for RSL1D1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RSL1D1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RSL1D1 35
  • 99.25 (n)
  • 99.39 (a)
RSL1D1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RSL1D1 35
  • 75.07 (n)
  • 65.97 (a)
RSL1D1 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RSL1D1 35
  • 78.38 (n)
  • 68.75 (a)
RSL1D1 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rsl1d1 35
  • 70.21 (n)
  • 61.23 (a)
Rsl1d1 16
Rsl1d1 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 45 (a)
OneToMany
-- 36
  • 37 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RSL1D1 36
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102552945 35
  • 68.97 (n)
  • 56.7 (a)
chicken
(Gallus gallus)
Aves RSL1D1 35
  • 56.24 (n)
  • 45.16 (a)
RSL1D1 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rsl1d1 35
  • 55.25 (n)
  • 48.64 (a)
zebrafish
(Danio rerio)
Actinopterygii RSL1D1 36
  • 35 (a)
OneToOne
si:dkey-16i5.10 35
  • 54 (n)
  • 44.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13096 36
  • 13 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F53F4.11 36
  • 13 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP30 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10596 36
  • 25 (a)
OneToOne
Species with no ortholog for RSL1D1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RSL1D1 Gene

ENSEMBL:
Gene Tree for RSL1D1 (if available)
TreeFam:
Gene Tree for RSL1D1 (if available)

Paralogs for RSL1D1 Gene

Pseudogenes.org Pseudogenes for RSL1D1 Gene

genes like me logo Genes that share paralogs with RSL1D1: view

No data available for Paralogs for RSL1D1 Gene

Variants for RSL1D1 Gene

Sequence variations from dbSNP and Humsavar for RSL1D1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs14817 -- 11,834,442(+) GTAAA(C/T)ACCTG utr-variant-3-prime
rs846155 -- 11,853,572(-) ccggg(C/T)gtggt upstream-variant-2KB
rs846156 -- 11,847,187(-) tgttg(C/G)ccagg intron-variant
rs1019813 -- 11,846,972(-) ctcaa(A/G)tgttc intron-variant
rs1019814 -- 11,846,907(-) TGCCT(A/G)AGTAT intron-variant

Relevant External Links for RSL1D1 Gene

HapMap Linkage Disequilibrium report
RSL1D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RSL1D1 Gene

Disorders for RSL1D1 Gene

Relevant External Links for RSL1D1

Genetic Association Database (GAD)
RSL1D1
Human Genome Epidemiology (HuGE) Navigator
RSL1D1
genes like me logo Genes that share disorders with RSL1D1: view

No data available for UniProtKB/Swiss-Prot for RSL1D1 Gene

Publications for RSL1D1 Gene

  1. CSIG inhibits PTEN translation in replicative senescence. (PMID: 18678645) Ma L. … Tong T. (Mol. Cell. Biol. 2008) 3 4 23
  2. Identification of differentially expressed genes in human trophoblast cells by DDRT-PCR. (PMID: 9859858) Huch G. … Denker H.-W. (Placenta 1998) 2 3 4
  3. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J. … Carter P. (Oncogene 2004) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Directed proteomic analysis of the human nucleolus. (PMID: 11790298) Andersen J.S. … Lamond A.I. (Curr. Biol. 2002) 3 4

Products for RSL1D1 Gene

Sources for RSL1D1 Gene

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