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RSL1D1 Gene

protein-coding   GIFtS: 55
GCID: GC16M011934

Ribosomal L1 Domain Containing 1

  Search for RSL1D1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal L1 Domain Containing 11 2     UTP302
Cellular Senescence-Inhibited Gene Protein2 3     Cellular Senescence Inhibited Gene Protein2
CATX-112 3     Ribosomal L1 Domain-Containing Protein 12
CSIG2 3     CATX113
PBK12 3     Protein PBK13

External Ids:    HGNC: 245341   Entrez Gene: 261562   Ensembl: ENSG000001714907   UniProtKB: O760213   

Export aliases for RSL1D1 gene to outside databases

Previous GC identifers: GC16M011839 GC16M011929 GC16M011844 GC16M011930 GC16M011931 GC16M011933


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RSL1D1 Gene:
RSL1D1 (ribosomal L1 domain containing 1) is a protein-coding gene. GO annotations related to this gene include structural constituent of ribosome and RNA binding.

Gene Wiki entry for RSL1D1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the RSL1D1 gene promoter:
         GR   Sox5   STAT1   RFX1   Elk-1   ISGF-3   GR-beta   FOXD1   AREB6   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRSL1D1 promoter sequence
   Search Chromatin IP Primers for RSL1D1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RSL1D1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.13   Ensembl cytogenetic band:  16p13.13   HGNC cytogenetic band: 16p13.13

RSL1D1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RSL1D1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M011934:  view genomic region     (about GC identifiers)

Start:
11,928,053 bp from pter      End:
11,945,442 bp from pter
Size:
17,390 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RL1D1_HUMAN, O76021 (See protein sequence)
Recommended Name: Ribosomal L1 domain-containing protein 1  
Size: 490 amino acids; 54973 Da
Sequence caution: Sequence=AAF98239.1; Type=Frameshift; Positions=394; Sequence=AAH19069.2; Type=Erroneous
initiation; Sequence=CAA07491.1; Type=Frameshift; Positions=486;
Secondary accessions: D3DUG7 Q2M1T7 Q6PL22 Q8IWS7 Q8WUZ1 Q9HDA9 Q9Y3Z9

Explore the universe of human proteins at neXtProt for RSL1D1: NX_O76021

Explore proteomics data for RSL1D1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys188
  • Modification sites at PhosphoSitePlus

  • See RSL1D1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056474.2  
    ENSEMBL proteins: 
     ENSP00000460871   ENSP00000379760   ENSP00000459207   ENSP00000347897   ENSP00000461513  
     ENSP00000460748   ENSP00000459622   ENSP00000458684   ENSP00000460343   ENSP00000459331  
     ENSP00000442089  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR023674 Ribosomal_L1-like
     IPR028364 Ribosomal_L1/biogenesis
     IPR016094 Ribosomal_L1_2-a/b-sand

    Graphical View of Domain Structure for InterPro Entry O76021

    ProtoNet protein and cluster: O76021

    UniProtKB/Swiss-Prot: RL1D1_HUMAN, O76021
    Similarity: Belongs to the ribosomal protein L1P family. Highly divergent


    Find genes that share domains with RSL1D1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0005515protein binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with RSL1D1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for RSL1D1:
     Decreased Tat-dependent transc  Decreased nuclei size in G2M  Decreased p24 protein expressi 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RSL1D1
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    miRTarBase miRNAs that target RSL1D1:
    hsa-let-7e-5p (MIRT051659), hsa-mir-193b-3p (MIRT041332), hsa-mir-103a-3p (MIRT027166), hsa-mir-16-5p (MIRT051068)

    Block miRNA regulation of human, mouse, rat RSL1D1 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RL1D1_HUMAN, O76021: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--

    Find genes that share ontologies with RSL1D1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RSL1D1 About    
    See pathways by source

    SuperPathContained pathways About
    1Senescence and Autophagy
    Senescence and Autophagy


    1 BioSystems Pathway for RSL1D1
        Senescence and Autophagy


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RSL1D1
    Interactions:

        Search GeneGlobe Interaction Network for RSL1D1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RSL1D1 (O760212, 3 ENSP000003797604) via UniProtKB, MINT, STRING, and/or I2D (see all 341)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K14Q995582, 3MINT-48797 I2D: score=2 
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    MED19A0JLT23, ENSP000003373404STRING: ENSP00000337340 I2D: score=1 
    MRGBPQ9NV563, ENSP000003595184I2D: score=2 STRING: ENSP00000359518
    RRP1BQ146843, ENSP000003391454I2D: score=1 STRING: ENSP00000339145
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032880regulation of protein localization IMP17158916

    Find genes that share ontologies with RSL1D1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RSL1D1 (RL1D1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RSL1D1 gene: 
    NM_015659.2  

    Unigene Cluster for RSL1D1:

    Ribosomal L1 domain containing 1
    Hs.401842  [show with all ESTs]
    Unigene Representative Sequence: NM_015659
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000571133(uc002dbp.1 uc010buv.1 uc010uyw.1 uc010buw.2)
    ENST00000396503 ENST00000573618 ENST00000355674 ENST00000573029 ENST00000573251
    ENST00000574823 ENST00000570767 ENST00000572090 ENST00000571988 ENST00000573791
    ENST00000574287 ENST00000542106
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RSL1D1
      QuantiFast Probe-based Assays in human, mouse, rat RSL1D1

    Additional mRNA sequence: 

    AF074987.1 AF083127.1 AJ007398.1 AK000822.1 AK025446.1 AK295935.1 AL049999.1 AY154473.1 
    AY598331.1 BC009802.1 BC016362.1 BC017899.1 BC019069.2 BC070325.1 BC107782.1 BC112228.1 
    BC113699.1 

    Selected DOTS entries (see all 26):

    DT.100803674  DT.120689619  DT.91807055  DT.100877588  DT.216838  DT.412549  DT.100016522  DT.99995224 
    DT.120689700  DT.100877584  DT.100877591  DT.120689644  DT.75190628  DT.95331976  DT.95070861  DT.100830607 
    DT.100877571  DT.100877579  DT.100877582  DT.120689642  DT.120689727  DT.120689750  DT.120712485  DT.120689622 

    15 AceView cDNA sequences:

    BC019069 AY598331 AF083127 BC009802 BC017899 AJ007398 AL049999 AY154473 
    BC070325 AK025446 BC016362 NM_015659 BQ652858 BF701221 BI117548 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RSL1D1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:                    -                                   -               
    SP2:        -     -     -     -     -     -                 -               
    SP3:                                                                        
    SP4:                                                                        


    ECgene alternative splicing isoforms for RSL1D1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RSL1D1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGTGGACA
    RSL1D1 Expression
    About this image


    RSL1D1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
     
     Testis (Reproductive System)
    RSL1D1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RSL1D1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.401842

    UniProtKB/Swiss-Prot: RL1D1_HUMAN, O76021
    Tissue specificity: Placenta

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RSL1D1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rsl1d11 , 5 ribosomal L1 domain containing 11, 5 70.21(n)1
    61.23(a)1
      16 (6.37 cM)5
    664091  NM_025546.21  NP_079822.11 
     111929705 
    chicken
    (Gallus gallus)
    Aves RSL1D11 ribosomal L1 domain containing 1 56.24(n)
    45.16(a)
      416416  NM_001039263.2  NP_001034352.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia BG552410.12   -- 72.94(n)    BG552410.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-16i5.101 si:dkey-16i5.10 54(n)
    44.4(a)
      563247  XM_681022.5  XP_686114.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG130966
    --
    13(a)
    1 ↔ 1
    2L(8509251-8511844)
    worm
    (Caenorhabditis elegans)
    Secernentea F53F4.116
    Protein F53F4.11 (F53F4.11) mRNA, complete cds
    13(a)
    1 ↔ 1
    V(13622105-13624521) WBGene00009993


    ENSEMBL Gene Tree for RSL1D1 (if available)
    TreeFam Gene Tree for RSL1D1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RSL1D1 gene

    Find genes that share paralogs with RSL1D1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for RSL1D1
    PGOHUM00000243729 PGOHUM00000236672


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RSL1D1 (see all 551)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1854362641,2
    C--11927597(+) CTCAGC/GTGATC 1 -- ds50010--------
    rs1434345471,2
    --11927629(+) TTGCTA/GGGATT 1 -- ds50010--------
    rs666175791,2
    C--11927744(+) TTCCT-/AAAAAA 1 -- ds50010--------
    rs22159281,2
    C,F,A,H--11927918(-) GTATAT/AGATGT 1 -- ds500129Minor allele frequency- A:0.29NS EA NA CSA WA 3136
    rs21926451,2
    C,F,O,A,H--11928019(-) GCTTCA/GGAAGT 1 -- ds500131Minor allele frequency- G:0.35NA NS EA WA CSA 2921
    rs1884443751,2
    --11928037(+) ACATAA/GTACAG 1 -- ds50010--------
    rs1928607381,2
    --11928136(+) CATACC/GACCAT 1 -- ut310--------
    rs616605061,2
    C,F--11928258(+) GAGAAG/CATTAT 1 -- ut311Minor allele frequency- C:0.50WA 2
    rs148171,2
    C,F,H--11928299(+) GTAAAC/TACCTG 1 -- ut3114Minor allele frequency- T:0.03MN NS EA NA WA 1820
    rs1847874351,2
    --11928394(+) AAAACA/CACACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RSL1D1 (11928053 - 11945442 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RSL1D1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RSL1D1
    DNA2.0 Custom Variant and Variant Library Synthesis for RSL1D1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with RSL1D1           About GenesLikeMe

    Genetic Association Database (GAD): RSL1D1
    Human Genome Epidemiology (HuGE) Navigator: RSL1D1 (1 document)

    Export disorders for RSL1D1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RSL1D1 gene, integrated from 10 sources (see all 59):
    (articles sorted by number of sources associating them with RSL1D1)
        Utopia: connect your pdf to the dynamic
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    1. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PubMed id 15334068)1, 2, 3 Petroziello J.... Carter P. (Oncogene 2004)
    2. Identification of differentially expressed genes in human trophoblast cells by DDRT-PCR. (PubMed id 9859858)1, 2, 3 Huch G.... Denker H.-W. (Placenta 1998)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    7. Directed proteomic analysis of the human nucleolus. (PubMed id 11790298)1, 2 Andersen J.S.... Lamond A.I. (Curr. Biol. 2002)
    8. CSIG inhibits PTEN translation in replicative senescence. (PubMed id 18678645)1, 9 Ma L....Tong T. (Mol. Cell. Biol. 2008)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26156 HGNC: 24534 AceView: DKFZP564M182 Ensembl:ENSG00000171490 euGenes: HUgn26156
    ECgene: RSL1D1 H-InvDB: RSL1D1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RSL1D1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RSL1D1 gene:
    Search GeneIP for patents involving RSL1D1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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