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Aliases for RSL1D1 Gene

Aliases for RSL1D1 Gene

  • Ribosomal L1 Domain Containing 1 2 3 5
  • Cellular Senescence-Inhibited Gene Protein 3 4
  • CATX-11 3 4
  • CSIG 3 4
  • PBK1 3 4
  • Ribosomal L1 Domain-Containing Protein 1 3
  • Protein PBK1 4
  • CATX11 4
  • UTP30 3
  • L12 3

External Ids for RSL1D1 Gene

Previous GeneCards Identifiers for RSL1D1 Gene

  • GC16M011839
  • GC16M011929
  • GC16M011844
  • GC16M011930
  • GC16M011931
  • GC16M011933
  • GC16M011934

Summaries for RSL1D1 Gene

GeneCards Summary for RSL1D1 Gene

RSL1D1 (Ribosomal L1 Domain Containing 1) is a Protein Coding gene. Diseases associated with RSL1D1 include Bowen-Conradi Syndrome. Among its related pathways are Senescence and Autophagy. GO annotations related to this gene include poly(A) RNA binding and RNA binding.

UniProtKB/Swiss-Prot for RSL1D1 Gene

  • Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.

Gene Wiki entry for RSL1D1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSL1D1 Gene

Genomics for RSL1D1 Gene

Regulatory Elements for RSL1D1 Gene

Enhancers for RSL1D1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RSL1D1 on UCSC Golden Path with GeneCards custom track

Promoters for RSL1D1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RSL1D1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RSL1D1 Gene

Chromosome:
16
Start:
11,833,850 bp from pter
End:
11,851,585 bp from pter
Size:
17,736 bases
Orientation:
Minus strand

Genomic View for RSL1D1 Gene

Genes around RSL1D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RSL1D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RSL1D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSL1D1 Gene

Proteins for RSL1D1 Gene

  • Protein details for RSL1D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76021-RL1D1_HUMAN
    Recommended name:
    Ribosomal L1 domain-containing protein 1
    Protein Accession:
    O76021
    Secondary Accessions:
    • B4DJ58
    • D3DUG7
    • Q2M1T7
    • Q6PL22
    • Q8IWS7
    • Q8WUZ1
    • Q9HDA9
    • Q9Y3Z9

    Protein attributes for RSL1D1 Gene

    Size:
    490 amino acids
    Molecular mass:
    54973 Da
    Quaternary structure:
    • Interacts with ING1 (isoform 2).
    SequenceCaution:
    • Sequence=AAF98239.1; Type=Frameshift; Positions=394; Evidence={ECO:0000305}; Sequence=AAH19069.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA07491.1; Type=Frameshift; Positions=486; Evidence={ECO:0000305};

    Alternative splice isoforms for RSL1D1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RSL1D1 Gene

Post-translational modifications for RSL1D1 Gene

  • Ubiquitination at Lys 188
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RSL1D1 Gene

Domains & Families for RSL1D1 Gene

Protein Domains for RSL1D1 Gene

Graphical View of Domain Structure for InterPro Entry

O76021

UniProtKB/Swiss-Prot:

RL1D1_HUMAN :
  • Belongs to the ribosomal protein L1P family. Highly divergent.
Family:
  • Belongs to the ribosomal protein L1P family. Highly divergent.
genes like me logo Genes that share domains with RSL1D1: view

No data available for Gene Families for RSL1D1 Gene

Function for RSL1D1 Gene

Molecular function for RSL1D1 Gene

UniProtKB/Swiss-Prot Function:
Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.
UniProtKB/Swiss-Prot Induction:
Down-regulated during cellular senescence.

Gene Ontology (GO) - Molecular Function for RSL1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0005515 protein binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with RSL1D1: view
genes like me logo Genes that share phenotypes with RSL1D1: view

Animal Model Products

CRISPR Products

miRNA for RSL1D1 Gene

miRTarBase miRNAs that target RSL1D1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RSL1D1 Gene

Localization for RSL1D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RSL1D1 Gene

Nucleus, nucleolus. Note=Colocalizes with ING1 in the nucleolus after UV stress. {ECO:0000269 PubMed:22419112}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RSL1D1 Gene COMPARTMENTS Subcellular localization image for RSL1D1 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for RSL1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA,IDA 18678645
GO:0005913 cell-cell adherens junction IDA 25468996
GO:0016020 membrane IDA 16210410
GO:0022625 NOT cytosolic large ribosomal subunit IBA --
GO:0030686 90S preribosome IBA --
genes like me logo Genes that share ontologies with RSL1D1: view

Pathways & Interactions for RSL1D1 Gene

SuperPathways for RSL1D1 Gene

Superpath Contained pathways
1 Senescence and Autophagy
genes like me logo Genes that share pathways with RSL1D1: view

Pathways by source for RSL1D1 Gene

1 BioSystems pathway for RSL1D1 Gene

Gene Ontology (GO) - Biological Process for RSL1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000470 maturation of LSU-rRNA IBA --
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006412 NOT translation IBA --
GO:0032880 regulation of protein localization IMP 17158916
GO:0042981 regulation of apoptotic process IDA 18678645
genes like me logo Genes that share ontologies with RSL1D1: view

No data available for SIGNOR curated interactions for RSL1D1 Gene

Drugs & Compounds for RSL1D1 Gene

No Compound Related Data Available

Transcripts for RSL1D1 Gene

mRNA/cDNA for RSL1D1 Gene

Unigene Clusters for RSL1D1 Gene

Ribosomal L1 domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RSL1D1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1: - -
SP2: - - - - - - -
SP3:
SP4:

Relevant External Links for RSL1D1 Gene

GeneLoc Exon Structure for
RSL1D1
ECgene alternative splicing isoforms for
RSL1D1

Expression for RSL1D1 Gene

mRNA expression in normal human tissues for RSL1D1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RSL1D1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RSL1D1 Gene



Protein tissue co-expression partners for RSL1D1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RSL1D1 Gene:

RSL1D1

SOURCE GeneReport for Unigene cluster for RSL1D1 Gene:

Hs.401842

mRNA Expression by UniProt/SwissProt for RSL1D1 Gene:

O76021-RL1D1_HUMAN
Tissue specificity: Expressed at high intensities in the heart, skeletal muscle, and placenta.
genes like me logo Genes that share expression patterns with RSL1D1: view

Primer Products

No data available for mRNA differential expression in normal tissues for RSL1D1 Gene

Orthologs for RSL1D1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RSL1D1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RSL1D1 34
  • 75.07 (n)
  • 65.97 (a)
RSL1D1 35
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RSL1D1 34
  • 78.38 (n)
  • 68.75 (a)
RSL1D1 35
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rsl1d1 34
  • 70.21 (n)
  • 61.23 (a)
Rsl1d1 16
Rsl1d1 35
  • 58 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RSL1D1 34
  • 99.25 (n)
  • 99.39 (a)
RSL1D1 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102552945 34
  • 68.97 (n)
  • 56.7 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 45 (a)
OneToMany
-- 35
  • 37 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RSL1D1 35
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves RSL1D1 34
  • 56.24 (n)
  • 45.16 (a)
RSL1D1 35
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rsl1d1 34
  • 55.25 (n)
  • 48.64 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-16i5.10 34
  • 54 (n)
  • 44.4 (a)
RSL1D1 35
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13096 35
  • 13 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F53F4.11 35
  • 13 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP30 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10596 35
  • 25 (a)
OneToOne
Species where no ortholog for RSL1D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RSL1D1 Gene

ENSEMBL:
Gene Tree for RSL1D1 (if available)
TreeFam:
Gene Tree for RSL1D1 (if available)

Paralogs for RSL1D1 Gene

Pseudogenes.org Pseudogenes for RSL1D1 Gene

genes like me logo Genes that share paralogs with RSL1D1: view

No data available for Paralogs for RSL1D1 Gene

Variants for RSL1D1 Gene

Sequence variations from dbSNP and Humsavar for RSL1D1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3743590 -- 11,836,480(+) GGCCA(A/C)GTACC utr-variant-3-prime
rs3971913 -- 11,836,057(+) tccat(C/T)atctc utr-variant-3-prime
rs14817 -- 11,834,442(+) GTAAA(C/T)ACCTG utr-variant-3-prime
rs9923315 -- 11,843,684(+) TAACA(C/T)GGTAA intron-variant
rs9927739 -- 11,835,125(+) ACTCT(C/T)GCTAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RSL1D1 Gene

Variant ID Type Subtype PubMed ID
esv3637942 CNV gain 21293372
nsv1043909 CNV gain 25217958
nsv1120318 CNV tandem duplication 24896259
nsv571458 CNV gain 21841781

Variation tolerance for RSL1D1 Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.13; 38.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RSL1D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RSL1D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSL1D1 Gene

Disorders for RSL1D1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RSL1D1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bowen-conradi syndrome
  • bowen hutterite syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RSL1D1

Genetic Association Database (GAD)
RSL1D1
Human Genome Epidemiology (HuGE) Navigator
RSL1D1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RSL1D1
genes like me logo Genes that share disorders with RSL1D1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RSL1D1 Gene

Publications for RSL1D1 Gene

  1. CSIG inhibits PTEN translation in replicative senescence. (PMID: 18678645) Ma L. … Tong T. (Mol. Cell. Biol. 2008) 3 4 22 65
  2. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J. … Carter P. (Oncogene 2004) 2 3 4 65
  3. Identification of differentially expressed genes in human trophoblast cells by DDRT-PCR. (PMID: 9859858) Huch G. … Denker H.-W. (Placenta 1998) 2 3 4 65
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 65
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 65

Products for RSL1D1 Gene

Sources for RSL1D1 Gene

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