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Aliases for RSL1D1 Gene

Aliases for RSL1D1 Gene

  • Ribosomal L1 Domain Containing 1 2 3 5
  • Cellular Senescence-Inhibited Gene Protein 3 4
  • CATX-11 3 4
  • CSIG 3 4
  • PBK1 3 4
  • Cellular Senescence Inhibited Gene Protein 3
  • Protein PBK1 4
  • CATX11 4
  • UTP30 3
  • L12 3

External Ids for RSL1D1 Gene

Previous GeneCards Identifiers for RSL1D1 Gene

  • GC16M011839
  • GC16M011929
  • GC16M011844
  • GC16M011930
  • GC16M011931
  • GC16M011933
  • GC16M011934

Summaries for RSL1D1 Gene

GeneCards Summary for RSL1D1 Gene

RSL1D1 (Ribosomal L1 Domain Containing 1) is a Protein Coding gene. Among its related pathways are Senescence and Autophagy. GO annotations related to this gene include poly(A) RNA binding and RNA binding.

UniProtKB/Swiss-Prot for RSL1D1 Gene

  • Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.

Gene Wiki entry for RSL1D1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSL1D1 Gene

Genomics for RSL1D1 Gene

Regulatory Elements for RSL1D1 Gene

Enhancers for RSL1D1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RSL1D1 on UCSC Golden Path with GeneCards custom track

Promoters for RSL1D1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RSL1D1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RSL1D1 Gene

11,833,850 bp from pter
11,851,585 bp from pter
17,736 bases
Minus strand

Genomic View for RSL1D1 Gene

Genes around RSL1D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RSL1D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RSL1D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSL1D1 Gene

Proteins for RSL1D1 Gene

  • Protein details for RSL1D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribosomal L1 domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B4DJ58
    • D3DUG7
    • Q2M1T7
    • Q6PL22
    • Q8IWS7
    • Q8WUZ1
    • Q9HDA9
    • Q9Y3Z9

    Protein attributes for RSL1D1 Gene

    490 amino acids
    Molecular mass:
    54973 Da
    Quaternary structure:
    • Interacts with ING1 (isoform 2).
    • Sequence=AAF98239.1; Type=Frameshift; Positions=394; Evidence={ECO:0000305}; Sequence=AAH19069.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA07491.1; Type=Frameshift; Positions=486; Evidence={ECO:0000305};

    Alternative splice isoforms for RSL1D1 Gene


neXtProt entry for RSL1D1 Gene

Proteomics data for RSL1D1 Gene at MOPED

Post-translational modifications for RSL1D1 Gene

  • Ubiquitination at Lys 188
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RSL1D1 Gene

Domains & Families for RSL1D1 Gene

Protein Domains for RSL1D1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L1P family. Highly divergent.
  • Belongs to the ribosomal protein L1P family. Highly divergent.
genes like me logo Genes that share domains with RSL1D1: view

No data available for Gene Families for RSL1D1 Gene

Function for RSL1D1 Gene

Molecular function for RSL1D1 Gene

UniProtKB/Swiss-Prot Function:
Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.
UniProtKB/Swiss-Prot Induction:
Down-regulated during cellular senescence.
genes like me logo Genes that share phenotypes with RSL1D1: view

Animal Model Products

miRNA for RSL1D1 Gene

miRTarBase miRNAs that target RSL1D1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RSL1D1 Gene

Localization for RSL1D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RSL1D1 Gene

Nucleus, nucleolus. Note=Colocalizes with ING1 in the nucleolus after UV stress. {ECO:0000269 PubMed:22419112}.

Subcellular locations from

Jensen Localization Image for RSL1D1 Gene COMPARTMENTS Subcellular localization image for RSL1D1 gene
Compartment Confidence
nucleus 5
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for RSL1D1 Gene

Pathways & Interactions for RSL1D1 Gene

SuperPathways for RSL1D1 Gene

Superpath Contained pathways
1 Senescence and Autophagy
genes like me logo Genes that share pathways with RSL1D1: view

Pathways by source for RSL1D1 Gene

1 BioSystems pathway for RSL1D1 Gene

Gene Ontology (GO) - Biological Process for RSL1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
genes like me logo Genes that share ontologies with RSL1D1: view

No data available for SIGNOR curated interactions for RSL1D1 Gene

Drugs & Compounds for RSL1D1 Gene

No Compound Related Data Available

Transcripts for RSL1D1 Gene

mRNA/cDNA for RSL1D1 Gene

Unigene Clusters for RSL1D1 Gene

Ribosomal L1 domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RSL1D1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1: - -
SP2: - - - - - - -

Relevant External Links for RSL1D1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RSL1D1 Gene

mRNA expression in normal human tissues for RSL1D1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RSL1D1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RSL1D1 Gene

SOURCE GeneReport for Unigene cluster for RSL1D1 Gene Hs.401842

mRNA Expression by UniProt/SwissProt for RSL1D1 Gene

Tissue specificity: Expressed at high intensities in the heart, skeletal muscle, and placenta.
genes like me logo Genes that share expression patterns with RSL1D1: view

Protein tissue co-expression partners for RSL1D1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for RSL1D1 Gene

Orthologs for RSL1D1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RSL1D1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RSL1D1 35
  • 75.07 (n)
  • 65.97 (a)
RSL1D1 36
  • 65 (a)
(Canis familiaris)
Mammalia RSL1D1 35
  • 78.38 (n)
  • 68.75 (a)
RSL1D1 36
  • 66 (a)
(Mus musculus)
Mammalia Rsl1d1 35
  • 70.21 (n)
  • 61.23 (a)
Rsl1d1 16
Rsl1d1 36
  • 58 (a)
(Pan troglodytes)
Mammalia RSL1D1 35
  • 99.25 (n)
  • 99.39 (a)
RSL1D1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC102552945 35
  • 68.97 (n)
  • 56.7 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 45 (a)
-- 36
  • 37 (a)
(Ornithorhynchus anatinus)
Mammalia RSL1D1 36
  • 43 (a)
(Gallus gallus)
Aves RSL1D1 35
  • 56.24 (n)
  • 45.16 (a)
RSL1D1 36
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rsl1d1 35
  • 55.25 (n)
  • 48.64 (a)
(Danio rerio)
Actinopterygii si:dkey-16i5.10 35
  • 54 (n)
  • 44.4 (a)
RSL1D1 36
  • 35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13096 36
  • 13 (a)
(Caenorhabditis elegans)
Secernentea F53F4.11 36
  • 13 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP30 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10596 36
  • 25 (a)
Species with no ortholog for RSL1D1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RSL1D1 Gene

Gene Tree for RSL1D1 (if available)
Gene Tree for RSL1D1 (if available)

Paralogs for RSL1D1 Gene Pseudogenes for RSL1D1 Gene

genes like me logo Genes that share paralogs with RSL1D1: view

No data available for Paralogs for RSL1D1 Gene

Variants for RSL1D1 Gene

Sequence variations from dbSNP and Humsavar for RSL1D1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs14817 -- 11,834,442(+) GTAAA(C/T)ACCTG utr-variant-3-prime
rs3971913 -- 11,836,057(+) tccat(C/T)atctc utr-variant-3-prime
rs13329866 -- 11,836,693(+) ACTCC(A/C)TGTTA utr-variant-3-prime
rs9923315 -- 11,843,684(+) TAACA(C/T)GGTAA intron-variant
rs4781159 -- 11,834,616(+) ACAAA(C/T)CAGAC utr-variant-3-prime

Variation tolerance for RSL1D1 Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.13; 38.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for RSL1D1 Gene

Disorders for RSL1D1 Gene

Relevant External Links for RSL1D1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RSL1D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RSL1D1 Gene

Publications for RSL1D1 Gene

  1. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J. … Carter P. (Oncogene 2004) 2 3 4 67
  2. CSIG inhibits PTEN translation in replicative senescence. (PMID: 18678645) Ma L. … Tong T. (Mol. Cell. Biol. 2008) 3 23
  3. Identification of differentially expressed genes in human trophoblast cells by DDRT-PCR. (PMID: 9859858) Huch G. … Denker H.-W. (Placenta 1998) 2 3
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  5. CSIG promotes hepatocellular carcinoma proliferation by activating c-MYC expression. (PMID: 25749381) Cheng Q. … Tong T. (Oncotarget 2015) 3

Products for RSL1D1 Gene

Sources for RSL1D1 Gene