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Aliases for RSG1 Gene

Aliases for RSG1 Gene

  • REM2 And RAB-Like Small GTPase 1 2 3
  • Rem/Rab-Similar GTPase 1 2 3
  • C1orf89 3 4
  • Miro Domain-Containing Protein C1orf89 3
  • Chromosome 1 Open Reading Frame 89 2
  • REM2- And Rab-Like Small GTPase 1 3

External Ids for RSG1 Gene

Previous Symbols for RSG1 Gene

  • C1orf89

Summaries for RSG1 Gene

GeneCards Summary for RSG1 Gene

RSG1 (REM2 And RAB-Like Small GTPase 1) is a Protein Coding gene. GO annotations related to this gene include GTP binding.

UniProtKB/Swiss-Prot for RSG1 Gene

  • Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSG1 Gene

Genomics for RSG1 Gene

Genomic Location for RSG1 Gene

Start:
16,231,687 bp from pter
End:
16,237,164 bp from pter
Size:
5,478 bases
Orientation:
Minus strand

Genomic View for RSG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RSG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSG1 Gene

No data available for Regulatory Elements for RSG1 Gene

Proteins for RSG1 Gene

  • Protein details for RSG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BU20-RSG1_HUMAN
    Recommended name:
    REM2- and Rab-like small GTPase 1
    Protein Accession:
    Q9BU20
    Secondary Accessions:
    • Q5TEV7

    Protein attributes for RSG1 Gene

    Size:
    258 amino acids
    Molecular mass:
    28498 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RSG1 Gene

Proteomics data for RSG1 Gene at MOPED

Post-translational modifications for RSG1 Gene

No Post-translational modifications

Other Protein References for RSG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RSG1 Gene

Domains for RSG1 Gene

Protein Domains for RSG1 Gene

UniProtKB/Swiss-Prot:

RSG1_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rab family.:
    • Q9BU20
genes like me logo Genes that share domains with RSG1: view

No data available for Gene Families for RSG1 Gene

Function for RSG1 Gene

Molecular function for RSG1 Gene

UniProtKB/Swiss-Prot Function: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity).

Gene Ontology (GO) - Molecular Function for RSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RSG1: view

Phenotypes for RSG1 Gene

GenomeRNAi human phenotypes for RSG1:
genes like me logo Genes that share phenotypes with RSG1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RSG1 Gene

Localization for RSG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RSG1 Gene

Cytoplasm, cytoskeleton, cilium basal body.

Gene Ontology (GO) - Cellular Components for RSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0036064 ciliary basal body ISS --
genes like me logo Genes that share ontologies with RSG1: view

Pathways for RSG1 Gene

SuperPathways for RSG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
GO:0017157 regulation of exocytosis ISS --
GO:0031338 regulation of vesicle fusion ISS --
genes like me logo Genes that share ontologies with RSG1: view

No data available for Pathways by source for RSG1 Gene

Transcripts for RSG1 Gene

mRNA/cDNA for RSG1 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RSG1 Gene

REM2 and RAB-like small GTPase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RSG1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
SP1:
SP2: -

Relevant External Links for RSG1 Gene

GeneLoc Exon Structure for
RSG1
ECgene alternative splicing isoforms for
RSG1

Expression for RSG1 Gene

mRNA expression in normal human tissues for RSG1 Gene

SOURCE GeneReport for Unigene cluster for RSG1 Gene Hs.546430

genes like me logo Genes that share expressions with RSG1: view

Orthologs for RSG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RSG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RSG1 36
  • 98.97 (n)
  • 99.22 (a)
RSG1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RSG1 36
  • 88.67 (n)
  • 91.41 (a)
RSG1 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RSG1 36
  • 89.49 (n)
  • 92.22 (a)
RSG1 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rsg1 36
  • 84.95 (n)
  • 89.11 (a)
Rsg1 16
Rsg1 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RSG1 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RSG1 37
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RSG1 37
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rsg1 36
  • 64.12 (n)
  • 63.56 (a)
zebrafish
(Danio rerio)
Actinopterygii rsg1 36
  • 63.49 (n)
  • 56.28 (a)
rsg1 37
  • 54 (a)
OneToOne
Species with no ortholog for RSG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RSG1 Gene

ENSEMBL:
Gene Tree for RSG1 (if available)
TreeFam:
Gene Tree for RSG1 (if available)

Paralogs for RSG1 Gene

No data available for Paralogs for RSG1 Gene

Variants for RSG1 Gene

Sequence variations from dbSNP and Humsavar for RSG1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs717863 -- 16,237,140(-) GGAAG(C/T)GGGCC utr-variant-5-prime
rs766009 -- 16,232,036(-) AGTGG(G/T)TGCCT utr-variant-3-prime
rs2863843 -- 16,234,519(+) TCTCA(C/T)TTATT intron-variant
rs2863844 -- 16,234,533(+) TTTTA(C/T)TTTTT intron-variant
rs2863845 -- 16,234,684(+) AAGGA(C/T)AACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RSG1 Gene

Variant ID Type Subtype PubMed ID
dgv174n71 CNV Loss 21882294
nsv833869 CNV Loss 17160897
nsv870978 CNV Loss 21882294
nsv3520 CNV Insertion 18451855

Relevant External Links for RSG1 Gene

HapMap Linkage Disequilibrium report
RSG1

Disorders for RSG1 Gene

No disorders were found for RSG1 Gene.

No data available for UniProtKB/Swiss-Prot for RSG1 Gene

Publications for RSG1 Gene

  1. The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development. (PMID: 19767740) Gray R.S. … Finnell R.H. (Nat. Cell Biol. 2009) 2 3
  2. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  3. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PMID: 22001757) Chambers J.C. … Kooner J.S. (Nat. Genet. 2011) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for RSG1 Gene

Sources for RSG1 Gene

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