RSG1 Gene
protein-coding GIFtS: 41
GCID: GC01M016557
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REM2 and RAB-like small GTPase 1(Previous name: chromosome 1 open reading frame 89 )
(Previous symbol: C1orf89)
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Aliases
for RSG1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| REM2 And RAB-Like Small GTPase 11 2 | | Miro Domain-Containing Protein C1orf892 | | C1orf891 2 3 | | Rem/Rab-Similar GTPase 12 | | MGC107311 | | REM2- And Rab-Like Small GTPase 12 | | Chromosome 1 Open Reading Frame 891 | | |
Export aliases for RSG1 gene to outside databases |
Summaries
for RSG1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RSG1_HUMAN, Q9BU20Function: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membranetrafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulatingthe transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved inexocytosis in secretory cells (By similarity)
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Genomic Views
for RSG1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for RSG1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RSG1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RSG1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.13 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36.13RSG1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M016557: view genomic region
(about GC identifiers)
Start:
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16,555,170 bp from pter |
End:
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16,563,659 bp from pter |
Size:
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8,490 bases |
Orientation:
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minus strand |
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Proteins
for RSG1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RSG1_HUMAN, Q9BU20 (See
protein sequence)Recommended Name: REM2- and Rab-like small GTPase 1 Size: 258 amino acids; 28498 Da
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body (By similarity)
Secondary accessions: Q5TEV7Explore the universe of human proteins at neXtProt for RSG1: NX_Q9BU20
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BU20
RSG1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_112169.2
ENSEMBL proteins: ENSP00000364749 ENSP00000406390
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RSG1 for ontologies About GeneDecksing
RSG1 Antibody Products:
Assay Products for RSG1: |
Protein
Domains /
Families
for RSG1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RSG1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BU20ProtoNet protein and cluster: Q9BU20 UniProtKB/Swiss-Prot: RSG1_HUMAN, Q9BU20Similarity: Belongs to the small GTPase superfamily. Rab family |
Function
for RSG1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RSG1_HUMAN, Q9BU20Function: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membranetrafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulatingthe transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved inexocytosis in secretory cells (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RSG1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RSG1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RSG1 (NM_030907) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RSG1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSG1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSG1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005525 | GTP binding |
IEA | -- |
RSG1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RSG1:
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Pathways & Interactions
for RSG1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RSG1
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for RSG1 (Q9BU203 ENSP000003647494) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
RSG1 for ontologies About GeneDecksing
|
Drugs & Compounds
for RSG1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RSG1
Search CenterWatch for drugs/clinical trials and news about RSG1
|
Transcripts
for RSG1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RSG1 gene: NM_030907.3 Unigene Cluster for RSG1: REM2 and RAB-like small GTPase 1 Hs.546430 [show with all ESTs]Unigene Representative Sequence: NM_0309073 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000488510 ENST00000375599(uc001ayd.3) ENST00000434014
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RSG1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RSG1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RSG1 (NM_030907) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RSG1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSG1 |
Additional cDNA sequence: BC002946.2 BC008702.1 1 DOTS entry: DT.75105204 21 AceView cDNA sequences: BC008702 BM806211 BM972129 CR594894 AI763332 NM_030907 BC002946 BE395771 AL559024 BG397004 AI744915 CD518311 BX092154 BX369457 BM695045 CD674700 BF026514 BM987595 AW905080 W02174 W32586
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for RSG1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 |
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| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for RSG1
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Expression
for RSG1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RSG1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAGGGAGGT
About this image
See RSG1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RSG1
SOURCE GeneReport for Unigene cluster: Hs.546430
SABiosciences Custom PCR Arrays for RSG1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RSG1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RSG1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RSG1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RSG1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSG1 |
Orthologs
for RSG1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RSG1 gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for RSG1 (if available)
TreeFam Gene Tree for RSG1 (if available) |
Paralogs
for RSG1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RSG1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RSG1 (16555170 - 16563659 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RSG1: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for RSG1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for RSG1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RSG1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RSG1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The planar cell polarity effector Fuz is essential fo r targeted membrane trafficking, ciliogenesis and mouse embryonic development. (PubMed id 19767740)1, 3 Gray R.S....Finnell R.H. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Genome-wide association study identifies loci influenc ing concentrations of liver enzymes in plasma. (PubMed id 22001757)1 Chambers J.C....Kooner J.S. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for RSG1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing RSG1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RSG1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RSG1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RSG1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RSG1 gene:
Search GeneIP for patents involving RSG1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RSG1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RSG1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RSG1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RSG1 | | | OriGene Protein Over-expression Lysate for RSG1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RSG1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RSG1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RSG1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RSG1 | | OriGene Custom Protein Services for RSG1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RSG1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RSG1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RSG1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RSG1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RSG1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RSG1 |
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 |  |  |  | |
| | | | Search Tocris compounds for RSG1 |
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 | | | RSG1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSG1 |
|  |  |  | | | | Search ThermoFisher Antibodies for RSG1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSG1 |
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