Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RSG1 Gene

Aliases for RSG1 Gene

  • REM2 And RAB Like Small GTPase 1 2 3 5
  • Rem/Rab-Similar GTPase 1 2 3
  • C1orf89 3 4
  • Miro Domain-Containing Protein C1orf89 3
  • Chromosome 1 Open Reading Frame 89 2
  • REM2- And Rab-Like Small GTPase 1 3
  • REM2 And RAB-Like Small GTPase 1 2

External Ids for RSG1 Gene

Previous HGNC Symbols for RSG1 Gene

  • C1orf89

Previous GeneCards Identifiers for RSG1 Gene

  • GC01M016557

Summaries for RSG1 Gene

GeneCards Summary for RSG1 Gene

RSG1 (REM2 And RAB Like Small GTPase 1) is a Protein Coding gene. GO annotations related to this gene include GTP binding.

UniProtKB/Swiss-Prot for RSG1 Gene

  • Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity).

Additional gene information for RSG1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSG1 Gene

Genomics for RSG1 Gene

Regulatory Elements for RSG1 Gene

Enhancers for RSG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H016366 1.4 ENCODE dbSUPER 25.5 -130.5 -130531 2 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 RSG1 FAM231A ARHGEF19 RNU1-1 LOC100421279 CD24P1 FBXO42 RPL22P3 SZRD1
GH01H016205 1.3 ENCODE dbSUPER 25.8 +30.3 30273 3 HDGF PKNOX1 ARNT ARID4B DMAP1 ZNF2 YY1 ZNF766 ZNF143 FOS ARHGEF19 RSG1 NBPF1 FAM131C ENSG00000224621 SZRD1 CROCC MFAP2 GC01P016210 ARHGEF19-AS1
GH01H016236 1.3 ENCODE dbSUPER 20.5 +0.3 285 2 HDGF ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 SP3 SP5 MXD4 ARHGEF19 RSG1 NECAP2 ARHGEF19-AS1 FAM131C ZBTB17 LINC01783 GC01M016230
GH01H016247 1.6 Ensembl ENCODE dbSUPER 15.2 -11.4 -11378 3 FOXA2 PKNOX1 ARNT FEZF1 YY1 ZNF766 REST ZNF592 MEF2D ZNF610 ARHGEF19 CROCC SPEN RSG1 SZRD1 FBXO42 ARHGEF19-AS1 RPL22P3 CROCCP2 ENSG00000237938
GH01H016187 1.5 Ensembl ENCODE dbSUPER 13.9 +49.0 48978 2 HDGF PKNOX1 ATF1 ARID4B SIN3A ZNF2 SLC30A9 ZNF143 RUNX3 DEK ARHGEF19 RSG1 TRE-TTC3-1 ARHGEF19-AS1 GC01P016173
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RSG1 on UCSC Golden Path with GeneCards custom track

Promoters for RSG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000002040 452 801 ARID4B SIN3A ZNF2 ZNF766 ZNF143 SP3 SP5 MXD4 REST SMARCB1

Genomic Location for RSG1 Gene

Chromosome:
1
Start:
16,231,687 bp from pter
End:
16,237,452 bp from pter
Size:
5,766 bases
Orientation:
Minus strand

Genomic View for RSG1 Gene

Genes around RSG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RSG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RSG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSG1 Gene

Proteins for RSG1 Gene

  • Protein details for RSG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BU20-RSG1_HUMAN
    Recommended name:
    REM2- and Rab-like small GTPase 1
    Protein Accession:
    Q9BU20
    Secondary Accessions:
    • Q5TEV7

    Protein attributes for RSG1 Gene

    Size:
    258 amino acids
    Molecular mass:
    28498 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RSG1 Gene

Post-translational modifications for RSG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RSG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RSG1 Gene

Domains & Families for RSG1 Gene

Gene Families for RSG1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RSG1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RSG1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BU20

UniProtKB/Swiss-Prot:

RSG1_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RSG1: view

Function for RSG1 Gene

Molecular function for RSG1 Gene

UniProtKB/Swiss-Prot Function:
Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity).

Phenotypes From GWAS Catalog for RSG1 Gene

Gene Ontology (GO) - Molecular Function for RSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RSG1: view
genes like me logo Genes that share phenotypes with RSG1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RSG1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RSG1 Gene

Localization for RSG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RSG1 Gene

Cytoplasm, cytoskeleton, cilium basal body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RSG1 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005929 cilium IEA --
GO:0036064 ciliary basal body ISS --
genes like me logo Genes that share ontologies with RSG1: view

Pathways & Interactions for RSG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006887 exocytosis IEA --
GO:0015031 protein transport IEA --
GO:0017157 regulation of exocytosis ISS --
GO:0030030 cell projection organization IEA --
genes like me logo Genes that share ontologies with RSG1: view

No data available for Pathways by source and SIGNOR curated interactions for RSG1 Gene

Drugs & Compounds for RSG1 Gene

No Compound Related Data Available

Transcripts for RSG1 Gene

mRNA/cDNA for RSG1 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RSG1 Gene

REM2 and RAB-like small GTPase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RSG1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RSG1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
SP1:
SP2: -

Relevant External Links for RSG1 Gene

GeneLoc Exon Structure for
RSG1
ECgene alternative splicing isoforms for
RSG1

Expression for RSG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RSG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RSG1 Gene:

RSG1

SOURCE GeneReport for Unigene cluster for RSG1 Gene:

Hs.546430

Evidence on tissue expression from TISSUES for RSG1 Gene

  • Skin(4.1)
genes like me logo Genes that share expression patterns with RSG1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RSG1 Gene

Orthologs for RSG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RSG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RSG1 33 34
  • 98.97 (n)
dog
(Canis familiaris)
Mammalia RSG1 33 34
  • 89.49 (n)
cow
(Bos Taurus)
Mammalia RSG1 33 34
  • 88.67 (n)
oppossum
(Monodelphis domestica)
Mammalia RSG1 34
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rsg1 33 16 34
  • 84.95 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RSG1 34
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RSG1 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rsg1 33
  • 64.12 (n)
zebrafish
(Danio rerio)
Actinopterygii rsg1 33 34
  • 63.49 (n)
Species where no ortholog for RSG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RSG1 Gene

ENSEMBL:
Gene Tree for RSG1 (if available)
TreeFam:
Gene Tree for RSG1 (if available)

Paralogs for RSG1 Gene

No data available for Paralogs for RSG1 Gene

Variants for RSG1 Gene

Sequence variations from dbSNP and Humsavar for RSG1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000774406 -- 16,233,069(+) TGGGA(A/G)GAATA intron-variant
rs1002216153 -- 16,238,719(+) AAACC(A/T)GATGA upstream-variant-2KB
rs1002548132 -- 16,234,911(+) TAGAG(A/C)TGGGG intron-variant
rs1003222729 -- 16,237,203(+) CGCGG(C/T)GCATG upstream-variant-2KB, utr-variant-5-prime
rs1003253844 -- 16,237,398(+) TGAAA(C/G)CCCCC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RSG1 Gene

Variant ID Type Subtype PubMed ID
esv3585333 CNV loss 21293372
nsv3520 CNV insertion 18451855
nsv545641 CNV loss 21841781
nsv833869 CNV loss 17160897
nsv954845 CNV deletion 24416366

Variation tolerance for RSG1 Gene

Residual Variation Intolerance Score: 74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RSG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RSG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSG1 Gene

Disorders for RSG1 Gene

Relevant External Links for RSG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RSG1

No disorders were found for RSG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RSG1 Gene

Publications for RSG1 Gene

  1. The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development. (PMID: 19767740) Gray RS … Finnell RH (Nature cell biology 2009) 2 3 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  5. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PMID: 22001757) Chambers JC … Kooner JS (Nature genetics 2011) 3 60

Products for RSG1 Gene

Sources for RSG1 Gene

Content
Loading form....