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Aliases & Descriptions for RSF1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| HBXAP 2, 3, 5 | | RSF-1 1, 2 | | Rsf-1 3 | | XAP8 1, 2, 3 | | p325 1, 2 |
| | | Descriptions |
|---|
| HBV pX associated protein-8 2 | | HBV pX-associated protein 8 3 | | Hepatitis B virus X-associated protein 2, 3 | | hepatitis B virus x associated protein 1, 2 | | p325 subunit of RSF chromatin-remodeling complex 3 | | remodeling and spacing factor 1 2 |
|
| | Search outside databases for aliases for RSF1 gene |
Summaries for RSF1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for RSF1: HBXAP is involved in transcription repression, transcription coactivation when associated with hepatitis B virus X protein (HBX), and chromatin remodeling and spacing when associated with SNF2H (MIM 603375).[supplied by OMIM] UniProtKB/Swiss-Prot: RSF1_HUMAN, Q96T23Function: Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex. Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domainGene Wiki entry for RSF1 |
Genomic Location for RSF1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RSF1 gene 
Entrez Gene cytogenetic band: 11q14.1 Ensembl cytogenetic band: 11q14.1 HGNC cytogenetic band: 11q13.5RSF1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M077055:
(about GC identifiers)
Start:
|
77,054,922 bp from pter |
End:
|
77,209,528 bp from pter |
Size:
|
154,607 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000011.8 NT_033927.7
| Proteins for RSF1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RSF1_HUMAN, Q96T23 (See
protein sequence)Recommended Name: Remodeling and spacing factor 1 Size: 1431 amino acids; 163006 Da
Subunit: Interacts with SMARCA5/SNF2H to form the RSF complex. Also binds the HBV pX/HBx protein, which is required to activate transcription of the viral genome
Subcellular location: Nucleus
Sequence caution: Sequence=AAG43114.1; Type=Frameshift; Positions=539; Sequence=BAA91591.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 476;
Secondary accessions: Q86X86 Q9H3L8 Q9NVZ8 Q9NYU0Alternative splicing: 3 isoforms: Q96T23-1 Q96T23-2 Q96T23-3 (Experimental confirmation may be lacking for some isoforms)Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_057662.3
ENSEMBL proteins: ENSP00000311513 ENSP00000353511
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for RSF1: Assays for RSF1: | Protein
Domains/ Families for RSF1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q96T23
ProtoNet protein and cluster: Q96T23 2 Blocks protein families: IPB001965 Zn-finger-like IPB004022 DDT domain
UniProtKB/Swiss-Prot: RSF1_HUMAN, Q96T23Similarity: Contains 1 DDT domainSimilarity: Contains 1 PHD-type zinc finger | Gene Function for RSF1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_016578
Applied Biosystems Silencer® siRNAs for RSF1
Sigma-Aldrich siRNA and siRNA Panels for RSF1  Sigma-Aldrich shRNA for RSF1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_016578                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016578                                  untagged cDNA clones in CMV expression vector (see all 2): BC015360 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_016578
UniProtKB/Swiss-Prot: RSF1_HUMAN, Q96T23Function: Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex. Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): About this table | Pathways & Interactions for RSF1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for RSF1 (Your Favorite Gene powered by Ingenuity) 
5/6 Interacting proteins for RSF1 (Q96T231 ENSP000003115133) via UniProtKB, MINT, and/or STRING (see all 6
)About this table
5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8
): About this table
|
Drugs & Compounds for RSF1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for RSF1 2 Novoseek chemical compound relationships for RSF1 gene
About this table
|
Transcripts for RSF1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_016578
Sigma-Aldrich siRNA and siRNA Panels for RSF1  Sigma-Aldrich shRNA for RSF1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_016578 REFSEQ mRNAs for RSF1 gene: NM_016578.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_016578               OriGene GFP tagged cDNA clone in CMV expression vector: NM_016578                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016578                                  untagged cDNA clones in CMV expression vector (see all 2): BC015360  Additional cDNA sequence: AF059317.1 AF227948.2 AF380176.1 AK001268.1 AK098130.1 BC000774.2 BC015360.1 BC046124.1 BC046347.1 8 DOTS entries: DT.433915 DT.455451 DT.91727429 DT.120728130 DT.100771524 DT.120728093 DT.120728149 DT.86791219 24/319 AceView cDNA sequences (see all 319
):AI804446 AW268852 AA031624 BQ959557 AA482600 CA842742 BI963956 BQ027318 AL600138 BQ014494 BU737872 BQ012722 BC011205 AI673308 AA694363 AI300574 AI572186 BU785540 AI283370 AW292415 AI571542 AA760914 AI080249 AA488345
highest scoring ESTs for RSF1:AA074879 AA280203 AA188500 AW793448 BE019573 BU949936 AA034408 AA034409 AA074861 AA074880 Unigene Cluster for RSF1: Remodeling and spacing factor 1 Hs.420229 [show with all ESTs]Unigene Representative Sequence: AF227948
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000308488
ENST00000360355
|
Expression for RSF1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RSF1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RSF1
1 / 2 / 3 11 probe-sets matching RSF1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GAAATGCATT
SOURCE GeneReport for Unigene cluster: Hs.420229 UniProtKB/Swiss-Prot: RSF1_HUMAN, Q96T23Tissue specificity: Ubiquitously expressed |
Orthologs for RSF1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RSF1 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for RSF1
ENSEMBL Gene Tree for RSF1 | Paralogs for RSF1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for RSF1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RSF1 (up to first 250kb)
|
Disorders & Mutations for RSF1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 608522
10/11 Novoseek disease relationships for RSF1 gene (see all 11
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hepatitis b |
88.67 |
214 |
16677157 (4), 11278765 (2), 16169872 (2), 17187364 (2) (see all 99) |
| hepatocellular carcinoma |
80.66 |
29 |
16219135 (2), 9638654 (1), 17187364 (1), 18264140 (1) (see all 28) |
| hepatitis b chronic |
66.35 |
1 |
19263472 (1) |
| hepatitis chronic |
48.10 |
3 |
2156203 (1), 16554914 (1), 11692143 (1) |
| tumors |
33.56 |
8 |
11278765 (1), 9405677 (1), 9755238 (1), 16172393 (1) (see all 8) |
| liver cirrhosis |
32.11 |
1 |
16554914 (1) |
| liver diseases |
23.45 |
1 |
11555189 (1) |
| immunodeficiency |
1.61 |
3 |
2191500 (1), 1309924 (1), 2335828 (1) |
| necrosis |
0.00 |
1 |
9755238 (1) |
| metastasis |
0.00 |
1 |
17187364 (1) |
About this table
|
Medical News for RSF1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RSF1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/154 PubMed articles for RSF1 gene (see all 154
):- Functional analysis of the subunits of the chromatin assembly factor RSF. (PubMed id 12972596)1, 2, 3, 4 Loyola A....Reinberg D. (2003)
- Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription. (PubMed id 11788598)2, 3, 4 Shamay M.... Shaul Y. (2002)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)3, 4 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- HBXAP, a novel PHD-finger protein, possesses transcription repression activity. (PubMed id 11944984)3, 4 Shamay M.... Shaul Y. (2002)
- Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma. (PubMed id 16172393)1, 3 Shih I.e.M....Wang T.L. (2005)
- Identification of remodeling and spacing factor 1 (rsf-1, HBXAP) at chromosome 11q13 as a putative oncogene in ovarian cancer. (PubMed id 16418735)1, 3 Hennessy B.T....Mills G.B. (2006)
- Hepatitis B virus X protein interacts with a probable cellular DNA repair protein. (PubMed id 7815490)1, 3 Lee T.H.... Butel J.S. (1995)
|
Search for RSF1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RSF1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RSF1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RSF1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RSF1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RSF1:

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