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Aliases for RSF1 Gene

Aliases for RSF1 Gene

  • Remodeling And Spacing Factor 1 2 3 5
  • P325 Subunit Of RSF Chromatin-Remodeling Complex 3 4
  • Hepatitis B Virus X Associated Protein 2 3
  • Hepatitis B Virus X-Associated Protein 3 4
  • HBV PX-Associated Protein 8 3 4
  • RSF-1 3 4
  • HBXAP 3 4
  • XAP8 3 4
  • HBV PX Associated Protein-8 3
  • P325 3

External Ids for RSF1 Gene

Previous HGNC Symbols for RSF1 Gene

  • HBXAP

Previous GeneCards Identifiers for RSF1 Gene

  • GC11M077055
  • GC11M077371
  • GC11M073675

Summaries for RSF1 Gene

Entrez Gene Summary for RSF1 Gene

  • This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this protein as the histone chaperone. [provided by RefSeq, Sep 2011]

GeneCards Summary for RSF1 Gene

RSF1 (Remodeling And Spacing Factor 1) is a Protein Coding gene. Diseases associated with RSF1 include hepatitis b and hepatitis. Among its related pathways are Cell Cycle, Mitotic and Chromosome Maintenance. GO annotations related to this gene include ATPase activity and histone binding.

UniProtKB/Swiss-Prot for RSF1 Gene

  • Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex. Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain.

Gene Wiki entry for RSF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSF1 Gene

Genomics for RSF1 Gene

Regulatory Elements for RSF1 Gene

Enhancers for RSF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RSF1 on UCSC Golden Path with GeneCards custom track

Promoters for RSF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RSF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RSF1 Gene

Chromosome:
11
Start:
77,659,996 bp from pter
End:
77,821,017 bp from pter
Size:
161,022 bases
Orientation:
Minus strand

Genomic View for RSF1 Gene

Genes around RSF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RSF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RSF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSF1 Gene

Proteins for RSF1 Gene

  • Protein details for RSF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96T23-RSF1_HUMAN
    Recommended name:
    Remodeling and spacing factor 1
    Protein Accession:
    Q96T23
    Secondary Accessions:
    • Q86X86
    • Q9H3L8
    • Q9NVZ8
    • Q9NYU0

    Protein attributes for RSF1 Gene

    Size:
    1441 amino acids
    Molecular mass:
    163821 Da
    Quaternary structure:
    • Interacts with SMARCA5/SNF2H to form the RSF complex. Also binds the HBV pX/HBx protein, which is required to activate transcription of the viral genome.
    SequenceCaution:
    • Sequence=AAG43114.1; Type=Frameshift; Positions=549; Evidence={ECO:0000305}; Sequence=AAH46124.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAK57515.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91591.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RSF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RSF1 Gene

Proteomics data for RSF1 Gene at MOPED

Post-translational modifications for RSF1 Gene

  • Ubiquitination at Lys 89, Lys 189, Lys 215, Lys 288, and Lys 463
  • Modification sites at PhosphoSitePlus

Other Protein References for RSF1 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for RSF1

No data available for DME Specific Peptides for RSF1 Gene

Domains & Families for RSF1 Gene

Gene Families for RSF1 Gene

Suggested Antigen Peptide Sequences for RSF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96T23

UniProtKB/Swiss-Prot:

RSF1_HUMAN :
  • Contains 1 DDT domain.
  • Contains 1 PHD-type zinc finger.
Domain:
  • Contains 1 DDT domain.
Similarity:
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with RSF1: view

Function for RSF1 Gene

Molecular function for RSF1 Gene

UniProtKB/Swiss-Prot Function:
Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex. Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain.

Gene Ontology (GO) - Molecular Function for RSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12972596
genes like me logo Genes that share ontologies with RSF1: view
genes like me logo Genes that share phenotypes with RSF1: view

Animal Models for RSF1 Gene

MGI Knock Outs for RSF1:
  • Rsf1 tm1b(EUCOMM)Wtsi

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RSF1 Gene

Localization for RSF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RSF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RSF1 Gene COMPARTMENTS Subcellular localization image for RSF1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for RSF1 Gene

Pathways & Interactions for RSF1 Gene

genes like me logo Genes that share pathways with RSF1: view

Gene Ontology (GO) - Biological Process for RSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IDA,TAS 12972596
GO:0006338 chromatin remodeling IDA 9836642
GO:0034080 CENP-A containing nucleosome assembly TAS --
GO:0043392 negative regulation of DNA binding IDA 12972596
GO:0045892 negative regulation of transcription, DNA-templated IDA 11944984
genes like me logo Genes that share ontologies with RSF1: view

No data available for SIGNOR curated interactions for RSF1 Gene

Drugs & Compounds for RSF1 Gene

(2) Drugs for RSF1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for RSF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RSF1: view

Transcripts for RSF1 Gene

Unigene Clusters for RSF1 Gene

Remodeling and spacing factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RSF1 Gene

No ASD Table

Relevant External Links for RSF1 Gene

GeneLoc Exon Structure for
RSF1
ECgene alternative splicing isoforms for
RSF1

Expression for RSF1 Gene

mRNA expression in normal human tissues for RSF1 Gene

Protein differential expression in normal tissues from HIPED for RSF1 Gene

This gene is overexpressed in Adrenal (38.8) and Peripheral blood mononuclear cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RSF1 Gene



SOURCE GeneReport for Unigene cluster for RSF1 Gene Hs.420229

mRNA Expression by UniProt/SwissProt for RSF1 Gene

Q96T23-RSF1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with RSF1: view

Protein tissue co-expression partners for RSF1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RSF1 Gene

Orthologs for RSF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RSF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RSF1 35
  • 91.23 (n)
  • 90.97 (a)
RSF1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RSF1 35
  • 91.61 (n)
  • 91.49 (a)
RSF1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rsf1 35
  • 85.58 (n)
  • 83.33 (a)
Rsf1 16
Rsf1 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RSF1 35
  • 99.7 (n)
  • 99.58 (a)
RSF1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rsf1 35
  • 84.95 (n)
  • 82.61 (a)
oppossum
(Monodelphis domestica)
Mammalia RSF1 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves RSF1 35
  • 71.77 (n)
  • 70.79 (a)
RSF1 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RSF1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5886 35
zebrafish
(Danio rerio)
Actinopterygii si:dkey-21n12.1 35
  • 57.11 (n)
  • 52.66 (a)
wufi20e01 35
RSF1 (1 of 3) 36
  • 36 (a)
OneToMany
RSF1 (2 of 3) 36
  • 42 (a)
OneToMany
RSF1 (3 of 3) 36
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8677 36
  • 11 (a)
OneToOne
Species with no ortholog for RSF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RSF1 Gene

ENSEMBL:
Gene Tree for RSF1 (if available)
TreeFam:
Gene Tree for RSF1 (if available)

Paralogs for RSF1 Gene

No data available for Paralogs for RSF1 Gene

Variants for RSF1 Gene

Sequence variations from dbSNP and Humsavar for RSF1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs7950873 - 77,701,806(+) CTTAG(A/C/G)GGGGC reference, missense
rs58758035 - 77,702,317(+) TTTTT(G/T)TCTTC reference, missense
rs529181 -- 77,795,649(+) tgaaa(A/T)aactg intron-variant
rs530575 -- 77,728,902(-) tttTT(A/T)GTAAA intron-variant
rs530693 -- 77,728,867(-) ttttt(A/T)acaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RSF1 Gene

Variant ID Type Subtype PubMed ID
nsv468641 CNV Gain 19166990
esv2562636 CNV Deletion 19546169
esv1937409 CNV Deletion 18987734
esv2673298 CNV Deletion 23128226
esv2612929 CNV Deletion 19546169
nsv398 CNV Insertion 18451855
nsv507600 CNV Insertion 20534489
esv2516959 CNV Deletion 19546169
esv2071392 CNV Deletion 18987734
esv2744812 CNV Deletion 23290073

Variation tolerance for RSF1 Gene

Residual Variation Intolerance Score: 17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RSF1 Gene

HapMap Linkage Disequilibrium report
RSF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSF1 Gene

Disorders for RSF1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RSF1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatitis b
  • chronic hepatitis b
hepatitis
  • hepatitis a
malignant ovarian surface epithelial-stromal neoplasm
  • malignant ovarian surface epithelial-stromal tumor
ovary epithelial cancer
  • epithelial tumor of ovary
- elite association - COSMIC cancer census association via MalaCards
Search RSF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RSF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RSF1
genes like me logo Genes that share disorders with RSF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RSF1 Gene

Publications for RSF1 Gene

  1. Functional analysis of the subunits of the chromatin assembly factor RSF. (PMID: 12972596) Loyola A. … Reinberg D. (Mol. Cell. Biol. 2003) 2 3 4 23 67
  2. Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase. (PMID: 20228782) Sehdev A.S. … Shih I.e.M. (Mod. Pathol. 2010) 3 23
  3. Identification of remodeling and spacing factor 1 (rsf-1, HBXAP) at chromosome 11q13 as a putative oncogene in ovarian cancer. (PMID: 16418735) Hennessy B.T. … Mills G.B. (Eur. J. Hum. Genet. 2006) 3 23
  4. Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma. (PMID: 16172393) Shih I.e.M. … Wang T.L. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 23
  5. Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription. (PMID: 11788598) Shamay M. … Shaul Y. (J. Biol. Chem. 2002) 2 3

Products for RSF1 Gene

Sources for RSF1 Gene

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