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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RSF1 Gene

protein-coding   GIFtS: 55
GCID: GC11M077371

Remodeling And Spacing Factor 1

(Previous name: hepatitis B virus x associated protein)
(Previous symbol: HBXAP)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Remodeling And Spacing Factor 11 2     P325 Subunit Of RSF Chromatin-Remodeling Complex2 3
HBXAP1 2 3 5     RSF-12
Hepatitis B Virus X Associated Protein1 2     HBV PX Associated Protein-82
Hepatitis B Virus X-Associated Protein2 3     p3252
XAP82 3     Rsf-13
HBV PX-Associated Protein 82 3     

External Ids:    HGNC: 181181   Entrez Gene: 517732   Ensembl: ENSG000000486497   OMIM: 6085225   UniProtKB: Q96T233   

Export aliases for RSF1 gene to outside databases

Previous GC identifers: GC11M077055 GC11M073675


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RSF1 Gene:
This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates
transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this
interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF
chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this
protein as the histone chaperone. (provided by RefSeq, Sep 2011)

GeneCards Summary for RSF1 Gene: 
RSF1 (remodeling and spacing factor 1) is a protein-coding gene. Diseases associated with RSF1 include hepatitis b, and hepatitis, and among its related super-pathways are Packaging Of Telomere Ends and Cell Cycle, Mitotic. GO annotations related to this gene include histone binding and ATPase activity.

UniProtKB/Swiss-Prot: RSF1_HUMAN, Q96T23
Function: Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex. Facilitates
transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV,
together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription
when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain

Gene Wiki entry for RSF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RSF1 gene promoter:
         AML1a   p53   AP-2alpha isoform 3   AP-2alpha isoform 2   Nkx2-5   c-Myb   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRSF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RSF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RSF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.1   Ensembl cytogenetic band:  11q14.1   HGNC cytogenetic band: 11q14.1

RSF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RSF1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M077371:  view genomic region     (about GC identifiers)

Start:
77,371,041 bp from pter      End:
77,532,063 bp from pter
Size:
161,023 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RSF1_HUMAN, Q96T23 (See protein sequence)
Recommended Name: Remodeling and spacing factor 1  
Size: 1441 amino acids; 163821 Da
Subunit: Interacts with SMARCA5/SNF2H to form the RSF complex. Also binds the HBV pX/HBx protein, which is
required to activate transcription of the viral genome
Subcellular location: Nucleus
Sequence caution: Sequence=AAG43114.1; Type=Frameshift; Positions=549; Sequence=AAH46124.2; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAK57515.1; Type=Erroneous
initiation; Sequence=BAA91591.1; Type=Erroneous initiation;
Secondary accessions: Q86X86 Q9H3L8 Q9NVZ8 Q9NYU0
Alternative splicing: 3 isoforms:  Q96T23-1   Q96T23-2   Q96T23-3   

Explore the universe of human proteins at neXtProt for RSF1: NX_Q96T23

Explore proteomics data for RSF1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96T23

  • RSF1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RSF1 Protein Expression
    REFSEQ proteins: NP_057662.3  
    ENSEMBL proteins: 
     ENSP00000311513   ENSP00000434509   ENSP00000433603   ENSP00000432022   ENSP00000436728  
     ENSP00000436408   ENSP00000408844   ENSP00000353511  
    Reactome Protein details: Q96T23
    Human Recombinant Protein Products for RSF1: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RSF1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11788598
    GO:0005654nucleoplasm TAS--
    GO:0031213RSF complex IPI9836642

    RSF1 for ontologies           About GeneDecksing



    RSF1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PHF: Zinc fingers, PHD-type

    5 InterPro protein domains:
     IPR019786 Zinc_finger_PHD-type_CS
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR011011 Znf_FYVE_PHD
     IPR019787 Znf_PHD-finger

    Graphical View of Domain Structure for InterPro Entry Q96T23

    ProtoNet protein and cluster: Q96T23

    2 Blocks protein domains:
    IPB001965 Zn-finger-like
    IPB004022 DDT domain


    UniProtKB/Swiss-Prot: RSF1_HUMAN, Q96T23
    Similarity: Contains 1 DDT domain
    Similarity: Contains 1 PHD-type zinc finger


    RSF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RSF1_HUMAN, Q96T23
    Function: Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex. Facilitates
    transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV,
    together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription
    when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12972596
    GO:0008270zinc ion binding IEA--
    GO:0016887NOT ATPase activity IDA12972596
    GO:0042393histone binding IDA12972596
         
    RSF1 for ontologies           About GeneDecksing


    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RSF1 
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    SwitchGear 3'UTR luciferase reporter plasmidRSF1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSF1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RSF1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Packaging Of Telomere Ends
    Nucleosome assembly0.46
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.46
    2Cell Cycle
    Cell Cycle0.84
    3Meiotic Synapsis
    Chromosome Maintenance0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for RSF1
        Nucleosome assembly
    Cell Cycle
    Deposition of New CENPA-containing Nucleosomes at the Centromere
    Chromosome Maintenance



    RSF1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RSF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/30 Interacting proteins for RSF1 (Q96T231, 2, 3 ENSP000003115134) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMARCA5O602641, 3, ENSP000002831314EBI-926768,EBI-352588 I2D: score=2 STRING: ENSP00000283131
    NFKB1P198383, ENSP000002265744I2D: score=3 STRING: ENSP00000226574
    CENPAP494503, ENSP000003368684I2D: score=1 STRING: ENSP00000336868
    TRIM33Q9UPN93, ENSP000003512504I2D: score=1 STRING: ENSP00000351250
    SMAD2Q157963I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly TAS--
    GO:0006338chromatin remodeling IDA9836642
    GO:0006352DNA-dependent transcription, initiation IDA9836642
    GO:0016584nucleosome positioning IDA9836642
    GO:0034080CENP-A containing nucleosome assembly at centromere TAS--

    RSF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RSF1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RSF1

    4 Novoseek inferred chemical compound relationships for RSF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nitric oxide 0 2 10051498 (1), 11732012 (1)
    lipid 0 1 19105208 (1)
    serine 0 3 10090730 (1), 15614436 (1)
    vegf 0 1 14575563 (1)

    Search CenterWatch for drugs/clinical trials and news about RSF1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RSF1 gene: 
    NM_016578.3  

    Unigene Cluster for RSF1:

    Remodeling and spacing factor 1
    Hs.420229  [show with all ESTs]
    Unigene Representative Sequence: AF227948
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308488(uc001oyn.3) ENST00000480887(uc001oym.3) ENST00000529470
    ENST00000531026 ENST00000526324 ENST00000531768 ENST00000532556 ENST00000528095
    ENST00000534794 ENST00000440064 ENST00000467567(uc001oyo.1) ENST00000530604
    ENST00000360355
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate RSF1 (see all 25):
    hsa-miR-142-5p hsa-miR-582-3p hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-193a-3p hsa-miR-302e hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidRSF1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF059317.1 AF227948.2 AF380176.1 AK001268.1 AK098130.1 BC000774.2 BC015360.1 BC046124.1 
    BC046347.1 

    8 DOTS entries:

    DT.433915  DT.455451  DT.91727429  DT.120728130  DT.100771524  DT.120728093  DT.120728149  DT.86791219 

    24/319 AceView cDNA sequences (see all 319):

    AI799503 AW513458 AA031624 BI916193 AW182146 BQ959557 BE551278 AA905586 
    AI631022 NM_016578 BU949936 CA429597 BQ189227 BE669881 BC000774 AA075571 
    AW020634 BU683740 AA453817 AA961009 BE677088 AI655956 AI217097 AA074880 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RSF1 expression in normal human tissues (normalized intensities)      RSF1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATGCATT
    RSF1 Expression
    About this image


    RSF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             cd31+ cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             testis ; cells in seminiferus ducts   

    See RSF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RSF1

    SOURCE GeneReport for Unigene cluster: Hs.420229

    UniProtKB/Swiss-Prot: RSF1_HUMAN, Q96T23
    Tissue specificity: Ubiquitously expressed

        SABiosciences Custom PCR Arrays for RSF1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RSF1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rsf11 , 5 remodeling and spacing factor 11, 5 86.02(n)1
    84.09(a)1
      7 (53.55 cM)5
    2335321  NM_001081267.21  NP_001074736.11 
     975798975 
    chicken
    (Gallus gallus)
    Aves RSF11 remodeling and spacing factor 1 72.01(n)
    71.13(a)
      426483  XM_424124.3  XP_424124.3 
    lizard
    (Anolis carolinensis)
    Reptilia RSF16
    Uncharacterized protein
    65(a)
    1 ↔ 1
    GL343337.1(692241-717691)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480504772   -- 77(n)    48050477 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi20e012 Danio rerio cDNA clone IMAGE3820062, partial cds 74.38(n)    BC055567.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG86771 CG8677 40.03(n)
    26.13(a)
      35397  NM_136257.2  NP_610101.2 


    ENSEMBL Gene Tree for RSF1 (if available)
    TreeFam Gene Tree for RSF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2980 SNPs in RSF1 are shown (see all 2980)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1177653111,2
    C,F--77241676(+) AATATA/GTCCAG 1 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1841167901,2
    --77241694(+) GGAAAA/TTCCAA 1 -- ds50010--------
    rs10455901,2
    C,F--77241704(-) TGTGTG/TTGTGT 1 -- ds50019Minor allele frequency- T:0.37NA WA EA 370
    rs723015281,2
    C--77241720(+) ACACG-/CACA  
            
    CACAC
    1 -- ds50010--------
    rs1449375971,2
    --77241742(+) ACACAC/TGCTAA 1 -- ds50010--------
    rs1421945121,2
    --77241816(+) CTAAGA/GGCAAG 1 -- ds50010--------
    rs1443760251,2
    C--77241870(+) CAAATA/GTGCTA 1 -- ds50010--------
    rs1891297121,2
    --77241973(+) GCCAGA/GAGACA 1 -- ds50010--------
    rs115448761,2
    C--77242011(+) GTCCAC/TCCAGG 1 -- ds50012Minor allele frequency- T:0.00NA 4
    rs1478533671,2
    --77242063(+) CAGACA/GCAATA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for RSF1 (77371041 - 77532063 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for RSF1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1937409CNV Deletion18987734
    esv2562636CNV Deletion19546169
    esv2071392CNV Deletion18987734
    esv2612929CNV Deletion19546169
    esv2516959CNV Deletion19546169
    esv2744812CNV Deletion23290073
    esv2673298CNV Deletion23128226
    nsv398CNV Insertion18451855
    nsv507600CNV Insertion20534489
    nsv468641CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing RSF1:
    Ovarian Cancer
    SeqTarget long-range PCR primers for resequencing RSF1
    DNA2.0 Custom Variant and Variant Library Synthesis for RSF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608522    OMIM disorders: --

    20 diseases for RSF1:    About MalaCards
    hepatitis b    hepatitis    viral hepatitis    serous cystadenocarcinoma
    cystadenocarcinoma    liver cirrhosis    hepatocellular carcinoma    hepatoblastoma
    oral squamous cell carcinoma    liver disease    hypoxia    gastric adenocarcinoma
    retinoblastoma    ovarian cancer    nasopharyngitis    squamous cell carcinoma
    colon cancer    endotheliitis    adenocarcinoma    lung cancer

    1 disease from the University of Copenhagen DISEASES database for RSF1:
    Serous cystadenocarcinoma

    RSF1 for disorders           About GeneDecksing

    10/13 Novoseek inferred disease relationships for RSF1 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis b 88.8 237 16677157 (4), 11278765 (2), 16169872 (2), 17187364 (2) (see all 99)
    hepatocellular carcinoma 81.8 32 16219135 (2), 9638654 (1), 17187364 (1), 18264140 (1) (see all 31)
    hepatitis b chronic 65.5 1 19263472 (1)
    hepatitis chronic 46.3 3 2156203 (1), 16554914 (1), 11692143 (1)
    viral hepatitis 43.5 1 20155784 (1)
    liver cirrhosis 34.3 2 19746176 (1), 16554914 (1)
    tumors 34.1 9 11278765 (1), 9405677 (1), 9755238 (1), 16172393 (1) (see all 9)
    liver diseases 24.7 1 11555189 (1)
    ovarian cancer 7.03 6 16172393 (1), 16418735 (1)
    metastasis 6.57 1 17187364 (1)


    Export disorders for RSF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RSF1 gene, integrated from 9 sources (see all 195):
    (articles sorted by number of sources associating them with RSF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional analysis of the subunits of the chromatin assembly factor RSF. (PubMed id 12972596)1, 2, 3, 9 Loyola A.... Reinberg D. (2003)
    2. Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription. (PubMed id 11788598)1, 2, 3 Shamay M.... Shaul Y. (2002)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. HBXAP, a novel PHD-finger protein, possesses transcription repression activity. (PubMed id 11944984)1, 2 Shamay M.... Shaul Y. (2002)
    8. Serous tubal intraepithelial carcinoma upregulates ma rkers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyc lin E and fatty acid synthase. (PubMed id 20228782)1, 9 Sehdev A.S....Shih I.e.M. (2010)
    9. Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma. (PubMed id 16172393)1, 9 Shih I.e.M....Wang T.L. (2005)
    10. Identification of remodeling and spacing factor 1 (rsf-1, HBXAP) at chromosome 11q13 as a putative oncogene in ovarian cancer. (PubMed id 16418735)1, 9 Hennessy B.T....Mills G.B. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51773 HGNC: 18118 AceView: HBXAP Ensembl:ENSG00000048649 euGenes: HUgn51773
    ECgene: RSF1 H-InvDB: RSF1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RSF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RSF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RSF1 gene:
    Search GeneIP for patents involving RSF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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