RSC1A1 Gene
protein-coding GIFtS: 46
GCID: GC01P015986
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regulatory solute carrier protein, family 1, member 1
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Aliases
for RSC1A1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Regulatory Solute Carrier Protein, Family 1, Member 11 2 | | RS11 2 5 | | Transporter Regulator RS12 3 | | Regulatory Solute Carrier Protein Family 1 Member 12 | | HRS11 |
Export aliases for RSC1A1 gene to outside databasesPrevious GC identifers: GC01P015342 GC01P015123 GC01P015232 GC01P015349 GC01P015307 GC01P015731 GC01P015817 GC01P014505 |
Summaries
for RSC1A1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RSCA1_HUMAN, Q92681Function: Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependentexocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent,short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network
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Genomic Views
for RSC1A1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RSC1A1 gene promoter:
ER-alpha USF1 FOXD1 Nkx2-5 Ik-3 HSF2 USF-1 IRF-7A Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for RSC1A1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RSC1A1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.1 Ensembl cytogenetic band: 1p36.21 HGNC cytogenetic band: 1p36.1RSC1A1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P015986: view genomic region
(about GC identifiers)
Start:
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15,986,364 bp from pter |
End:
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15,988,217 bp from pter |
Size:
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1,854 bases |
Orientation:
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plus strand |
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Proteins
for RSC1A1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RSCA1_HUMAN, Q92681 (See
protein sequence)Recommended Name: Regulatory solute carrier protein family 1 member 1 Size: 617 amino acids; 66790 Da
Subunit: Interacts with YRDC (By similarity)
Subcellular location: Cell membrane. Nucleus. Golgi apparatus, trans-Golgi network. Note=Localizes at the inner side ofthe plasma membrane
Secondary accessions: B2RBP5Explore the universe of human proteins at neXtProt for RSC1A1: NX_Q92681
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92681
RSC1A1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006502.1
ENSEMBL proteins: ENSP00000341963
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
RSC1A1 for ontologies About GeneDecksing
RSC1A1 Antibody Products:
Assay Products for RSC1A1: |
Protein
Domains /
Families
for RSC1A1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RSC1A1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q92681ProtoNet protein and cluster: Q92681 1 Blocks protein family: IPB000449 Ubiquitin-associated domain
UniProtKB/Swiss-Prot: RSCA1_HUMAN, Q92681Domain: The tripeptides QCP and QSP mediate post-transcriptional down-regulation of SLC5A1 at the trans-Golgi network.They inhibit a monosaccharide-dependent exocytotic pathway of SLC5A1Similarity: Contains 1 UBA domain |
Function
for RSC1A1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RSCA1_HUMAN, Q92681Function: Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependentexocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent,short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network Genatlas biochemistry entry for RSC1A1:regulatory solute carrier protein family 1,member 1,membrane-associated modulator of the sodium-glucose cotransportsystem
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RSC1A1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RSC1A1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSC1A1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
RSC1A1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for RSC1A1:
Animal Models:
Mouse knock-out Rsc1a1tm1Koep for RSC1A1
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Rsc1a1):
RSC1A1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RSC1A1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RSC1A1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for RSC1A1 (Q926813 ENSP000003419634) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
RSC1A1 for ontologies About GeneDecksing
|
Drugs & Compounds
for RSC1A1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RSC1A1 for compounds About GeneDecksing
 Browse Tocris compounds for RSC1A1
1 Novoseek chemical compound relationship for RSC1A1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| glucose |
10.4 |
3 |
11562363 (3) |
Search CenterWatch for drugs/clinical trials and news about RSC1A1 / RSCA1
|
Transcripts
for RSC1A1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RSC1A1 gene: NM_006511.1 Unigene Cluster for RSC1A1: Regulatory solute carrier protein, family 1, member 1 Hs.239459 [show with all ESTs]Unigene Representative Sequence: NM_0065111 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000345034(uc010obn.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RSC1A1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RSC1A1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RSC1A1 (NM_006511) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RSC1A1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSC1A1 |
1 DOTS entry: DT.40207652 24/39 AceView cDNA sequences (see all 39): BX282087 AI174890 CB118357 AW022594 BN000122 BQ344702 CB132209 BI003879 BQ900982 BC006011 BX090334 NM_006511 BE246849 BP356564 BX482682 AL707355 AI268381 BE093517 BM454852 AK057374 AL598343 BE720494 AW937766 H61016
GeneLoc Exon Structure
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Expression
for RSC1A1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RSC1A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RSC1A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RSC1A1
SOURCE GeneReport for Unigene cluster: Hs.239459
UniProtKB/Swiss-Prot: RSCA1_HUMAN, Q92681Tissue specificity: Expressed in small intestine, kidney and brain
SABiosciences Custom PCR Arrays for RSC1A1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RSC1A1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RSC1A1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RSC1A1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RSC1A1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSC1A1 |
Orthologs
for RSC1A1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for RSC1A1 gene from 1/3 species (see all 3) About this table
ENSEMBL Gene Tree for RSC1A1 (if available)
TreeFam Gene Tree for RSC1A1 (if available) |
Paralogs
for RSC1A1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RSC1A1 gene
RSC1A1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for RSC1A1
PGOHUM00000249575
|
Genomic Variants
for RSC1A1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RSC1A1 (15986364 - 15988217 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RSC1A1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RSC1A1 |
|
Disorders
/ Diseases
for RSC1A1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 RSC1A1 for disorders About MalaCards
RSC1A1 for disorders About GeneDecksing
OMIM gene information: 601966
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: RSC1A1 (1 document)
Export disorders for RSC1A1 gene to outside databases
|
Publications
for RSC1A1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RSC1A1 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with RSC1A1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Transporter regulator RS1 (RSC1A1) coats the trans-Golgi network and migrates into the nucleus. (PubMed id 16788147)1, 2, 9 Kroiss M....Koepsell H. (2006)
- RS1 (RSC1A1) regulates the exocytotic pathway of Na+-D-glucose cotransporter SGLT1. (PubMed id 16788146)1, 2, 9 Veyhl M.... Koepsell H. (2006)
- Downregulation of the Na(+)- D-glucose cotransporter SGLT1 by protein RS1 (RSC1A1) is dependent on dynamin and protein kinase C. (PubMed id 14724758)1, 2, 9 Veyhl M....Koepsell H. (2003)
- Tripeptides of RS1 (RSC1A1) inhibit a monosaccharide-dependent exocytotic pathway of Na+-D-glucose cotransporter SGLT1 with high affinity. (PubMed id 17686765)1, 2 Vernaleken A.... Koepsell H. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The human gene of a protein that modifies Na(+)-D-glucose co- transport. (PubMed id 8836035)1, 2 Lambotte S.... Koepsell H. (1996)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1 Flachsbart F....Nebel A. (2010)
|
External Searches for RSC1A1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RSC1A1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RSC1A1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RSC1A1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RSC1A1 gene:
Search GeneIP for patents involving RSC1A1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RSC1A1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | RSC1A1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSC1A1 |
|  |  |  | | | | ThermoFisher Antibodies for RSC1A1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSC1A1 |
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