Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RSC1A1 Gene

protein-coding   GIFtS: 48
GCID: GC01P015986

Regulatory Solute Carrier Protein, Family 1, Member 1

  Search for RSC1A1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Regulatory Solute Carrier Protein, Family 1, Member 11 2
Transporter Regulator RS12 3
RS12 5
Regulatory Solute Carrier Protein Family 1 Member 12
hRS13

External Ids:    HGNC: 104581   Entrez Gene: 62482   Ensembl: ENSG000002156957   OMIM: 6019665   UniProtKB: Q926813   

Export aliases for RSC1A1 gene to outside databases

Previous GC identifers: GC01P015342 GC01P015123 GC01P015232 GC01P015349 GC01P015307 GC01P015731 GC01P015817 GC01P014505


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for RSC1A1 Gene:
RSC1A1 (regulatory solute carrier protein, family 1, member 1) is a protein-coding gene. GO annotations related to this gene include ion channel inhibitor activity.

UniProtKB/Swiss-Prot: RSCA1_HUMAN, Q92681
Function: Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and
PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits
glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the
trans-Golgi network




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the RSC1A1 gene promoter:
         ER-alpha   USF1   FOXD1   Nkx2-5   Ik-3   HSF2   USF-1   IRF-7A   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRSC1A1 promoter sequence
   Search Chromatin IP Primers for RSC1A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RSC1A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.1   Ensembl cytogenetic band:  1p36.21   HGNC cytogenetic band: 1p36.1

RSC1A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RSC1A1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P015986:  view genomic region     (about GC identifiers)

Start:
15,986,364 bp from pter      End:
15,988,217 bp from pter
Size:
1,854 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RSCA1_HUMAN, Q92681 (See protein sequence)
Recommended Name: Regulatory solute carrier protein family 1 member 1  
Size: 617 amino acids; 66790 Da
Subunit: Interacts with YRDC (By similarity)
Secondary accessions: B2RBP5

Explore the universe of human proteins at neXtProt for RSC1A1: NX_Q92681

Explore proteomics data for RSC1A1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys512, Lys522
  • Modification sites at PhosphoSitePlus

  • See RSC1A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006502.1  
    ENSEMBL proteins: 
     ENSP00000341963  

    RSC1A1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RSC1A1
    OriGene Protein Over-expression Lysate for RSC1A1
    OriGene MassSpec for RSC1A1
    OriGene Custom Protein Services for RSC1A1
    GenScript Custom Purified and Recombinant Proteins Services for RSC1A1
    Novus Biologicals RSC1A1 Protein
    Novus Biologicals RSC1A1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RSC1A1

     
    Search eBioscience for Proteins for RSC1A1 

    RSC1A1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RSC1A1
    Novus Biologicals RSC1A1 Antibodies
    Abcam antibodies for RSC1A1
    Cloud-Clone Corp. Antibodies for RSC1A1
    ThermoFisher Antibodies for RSC1A1
    LSBio Antibodies in human, mouse, rat for RSC1A1

    RSC1A1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RSC1A1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RSC1A1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RSC1A1
    Cloud-Clone Corp. CLIAs for RSC1A1
    Search eBioscience for ELISAs for RSC1A1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR015940 UBA/transl_elong_EF1B_N_euk

    Graphical View of Domain Structure for InterPro Entry Q92681

    ProtoNet protein and cluster: Q92681

    1 Blocks protein domain: IPB000449 Ubiquitin-associated domain

    UniProtKB/Swiss-Prot: RSCA1_HUMAN, Q92681
    Domain: The tripeptides QCP and QSP mediate post-transcriptional down-regulation of SLC5A1 at the trans-Golgi
    network. They inhibit a monosaccharide-dependent exocytotic pathway of SLC5A1
    Similarity: Contains 1 UBA domain


    Find genes that share domains with RSC1A1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RSCA1_HUMAN, Q92681
    Function: Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and
    PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits
    glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the
    trans-Golgi network

         Genatlas biochemistry entry for RSC1A1:
    regulatory solute carrier protein family 1,member 1,membrane-associated modulator of the sodium-glucose
    cotransport system

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008200ion channel inhibitor activity TAS8836035
         
    Find genes that share ontologies with RSC1A1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RSC1A1:
     Decreased mitotic index  Increased cell death HMECs cel 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rsc1a1):
     adipose tissue  behavior/neurological  digestive/alimentary  growth/size/body  homeostasis/metabolism 

    Find genes that share phenotypes with RSC1A1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rsc1a1tm1Koep for RSC1A1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RSC1A1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RSC1A1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RSC1A1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RSC1A1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat RSC1A1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RSC1A1
    SwitchGear 3'UTR luciferase reporter plasmidRSC1A1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RSC1A1
    Predesigned siRNA for gene silencing in human, mouse, rat RSC1A1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RSC1A1

    Clone
    Products:
         
    OriGene clones in human, mouse for RSC1A1 (see all 5)
    OriGene ORF clones in mouse, rat for RSC1A1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RSC1A1 (NM_006511)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RSC1A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSC1A1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RSC1A1
    Browse ESI BIO Cell Lines and PureStem Progenitors for RSC1A1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSC1A1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RSCA1_HUMAN, Q92681: Cell membrane. Nucleus. Golgi apparatus, trans-Golgi network. Note=Localizes at the inner
    side of the plasma membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    golgi apparatus4
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005886plasma membrane IDA--
    GO:0005903brush border IEA--

    Find genes that share ontologies with RSC1A1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RSC1A1
    Interactions:

        GeneGlobe Interaction Network for RSC1A1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for RSC1A1 (Q926813 ENSP000003419634) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKAG1P546193I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    LSM8ENSP000002492994STRING: ENSP00000249299
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006810transport TAS8836035
    GO:0050892intestinal absorption IEA--
    GO:0051051negative regulation of transport IDA2675563

    Find genes that share ontologies with RSC1A1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RSC1A1 (RSCA1)

    1 Novoseek inferred chemical compound relationship for RSC1A1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 10.4 3 11562363 (3)



    Find genes that share compounds with RSC1A1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RSC1A1 gene: 
    NM_006511.1  

    Unigene Cluster for RSC1A1:

    Regulatory solute carrier protein, family 1, member 1
    Hs.239459  [show with all ESTs]
    Unigene Representative Sequence: NM_006511
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000345034(uc010obn.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RSC1A1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RSC1A1
    SwitchGear 3'UTR luciferase reporter plasmidRSC1A1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RSC1A1
    Predesigned siRNA for gene silencing in human, mouse, rat RSC1A1
    Clone
    Products:
         
    OriGene clones in human, mouse for RSC1A1 (see all 5)
    OriGene ORF clones in mouse, rat for RSC1A1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RSC1A1 (NM_006511)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RSC1A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSC1A1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RSC1A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat RSC1A1
      QuantiTect SYBR Green Assays in human, mouse, rat RSC1A1
      QuantiFast Probe-based Assays in human, mouse, rat RSC1A1

    1 DOTS entry:

    DT.40207652 

    Selected AceView cDNA sequences (see all 39):

    BX282087 BN000122 CB132209 BX090334 AI174890 BQ900982 AW022594 BC006011 
    CB118357 NM_006511 BI003879 BQ344702 BX482682 BE093517 BE246849 AK057374 
    BM454852 AL598343 AI268381 AL707355 BP356564 AW937766 BE720494 AW407789 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RSC1A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RSC1A1 Expression
    About this image

    RSC1A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RSC1A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.239459

    UniProtKB/Swiss-Prot: RSCA1_HUMAN, Q92681
    Tissue specificity: Expressed in small intestine, kidney and brain

        Custom PCR Arrays for RSC1A1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for RSC1A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat RSC1A1
    QuantiTect SYBR Green Assays in human, mouse, rat RSC1A1
    QuantiFast Probe-based Assays in human, mouse, rat RSC1A1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSC1A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for RSC1A1 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rsc1a11 , 5 regulatory solute carrier protein, family 1, member more1, 5 73.42(n)1
    58.25(a)1
      4 (74.70 cM)5
    699941  NM_023544.51  NP_076033.41 
     1416838515 


    ENSEMBL Gene Tree for RSC1A1 (if available)
    TreeFam Gene Tree for RSC1A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RSC1A1 gene

    Find genes that share paralogs with RSC1A1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RSC1A1
    PGOHUM00000249575


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RSC1A1 (see all 31)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1438436331,2
    F--15988147(+) TTTGCA/GTCGAG 2 H R mis11Minor allele frequency- G:0.00NA 4548
    rs2002285151,2
    --15988190(+) TTGCTC/TGCAAA 2 L syn10--------
    rs1181871521,2
    C,F--15988202(+) AACATC/TGTAGT 2 I syn11Minor allele frequency- T:0.03EA 120
    rs1997404691,2
    C,F--15988205(+) ATCGTA/GGTTCC 2 V syn11Minor allele frequency- G:0.00EU 1313
    rs1909917621,2
    C--15988233(+) GTGGGA/CTAGAC 1 -- ds50010--------
    rs1840481131,2
    C--15988239(+) TAGACC/TGTTCT 1 -- ds50010--------
    rs1877498111,2
    C--15988268(+) AGAAAC/GCTCTC 1 -- ds50010--------
    rs1925741021,2
    --15988286(+) ACACGC/TACACA 1 -- ds50010--------
    rs1156818361,2
    C,F--15988359(+) TTTTTA/TAAGAT 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1381598401,2
    C--15988544(+) GAATGA/GGAGTA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for RSC1A1 (15986364 - 15988217 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RSC1A1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RSC1A1
    DNA2.0 Custom Variant and Variant Library Synthesis for RSC1A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601966    OMIM disorders: --


    Find genes that share disorders with RSC1A1           About GenesLikeMe

    Genetic Association Database (GAD): RSC1A1
    Human Genome Epidemiology (HuGE) Navigator: RSC1A1 (1 document)

    Export disorders for RSC1A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RSC1A1 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with RSC1A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Transporter regulator RS1 (RSC1A1) coats the trans-Golgi network and migrates into the nucleus. (PubMed id 16788147)1, 2, 9 Kroiss M....Koepsell H. (Am. J. Physiol. 2006)
    2. RS1 (RSC1A1) regulates the exocytotic pathway of Na+-D-glucose cotransporter SGLT1. (PubMed id 16788146)1, 2, 9 Veyhl M.... Koepsell H. (Am. J. Physiol. 2006)
    3. Downregulation of the Na(+)- D-glucose cotransporter SGLT1 by protein RS1 (RSC1A1) is dependent on dynamin and protein kinase C. (PubMed id 14724758)1, 2, 9 Veyhl M....Koepsell H. (J. Membr. Biol. 2003)
    4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    5. Tripeptides of RS1 (RSC1A1) inhibit a monosaccharide-dependent exocytotic pathway of Na+-D-glucose cotransporter SGLT1 with high affinity. (PubMed id 17686765)1, 2 Vernaleken A.... Koepsell H. (J. Biol. Chem. 2007)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The human gene of a protein that modifies Na(+)-D-glucose co- transport. (PubMed id 8836035)1, 2 Lambotte S.... Koepsell H. (DNA Cell Biol. 1996)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6248 HGNC: 10458 AceView: RSC1A1andDDI2 Ensembl:ENSG00000215695 euGenes: HUgn6248
    ECgene: RSC1A1 H-InvDB: RSC1A1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RSC1A1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RSC1A1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RSC1A1 gene:
    Search GeneIP for patents involving RSC1A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RSC1A1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for RSC1A1  
     OriGene MassSpec something-or-other for RSC1A1   OriGene clones in human, mouse for RSC1A1  
     OriGene qSTAR qPCR primer pairs in human, mouse for RSC1A1   OriGene Purified Protein for RSC1A1  
     OriGene ORF clones in mouse, rat for RSC1A1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RSC1A1   OriGene Custom Protein Services for RSC1A1  

     
     
     Block miRNA regulation of human, mouse, rat RSC1A1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RSC1A1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RSC1A1 Predesigned siRNA for gene silencing in human, mouse, rat RSC1A1
     QuantiFast Probe-based Assays in human, mouse, rat RSC1A1 QuantiTect SYBR Green Assays in human, mouse, rat RSC1A1
     Custom PCR Arrays for RSC1A1 Search Chromatin IP Primers for RSC1A1
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat RSC1A1  GeneGlobe Interaction Network for RSC1A1
     Regulatory tfbs in RSC1A1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RSC1A1 GenScript cDNA clones with any tag delivered in your preferred vector for RSC1A1
     GenScript Custom Assay Services for RSC1A1 GenScript Custom overexpressing Cell Line Services for RSC1A1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RSC1A1 (RSCA1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RSC1A1 antibodies
     RSC1A1 proteins
     RSC1A1 lysates
     Antibodies for RSC1A1
     See all of Abcam's Antibodies, Kits and Proteins for RSC1A1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RSC1A1
     Antibodies for RSC1A1
     ELISAs for RSC1A1
     CLIAs for RSC1A1



     Browse ESI BIO Cell Lines and PureStem Progenitors for RSC1A1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSC1A1
     SwitchGear 3'UTR luciferase reporter plasmids for RSC1A1
     SwitchGear Promoter luciferase reporter plasmids for RSC1A1
     ThermoFisher Antibodies for RSC1A1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSC1A1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RSC1A1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RSC1A1
     LSBio Antibodies in human, mouse, rat for RSC1A1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for RSC1A1
      Search eBioscience for proteins for RSC1A1
      Search eBioscience for elisas for RSC1A1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RSC1A1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4