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Aliases for RSC1A1 Gene

Aliases for RSC1A1 Gene

  • Regulatory Solute Carrier Protein, Family 1, Member 1 2 3
  • Transporter Regulator RS1 3 4
  • RS1 3 6
  • Regulatory Solute Carrier Protein Family 1 Member 1 3
  • HRS1 4

External Ids for RSC1A1 Gene

Previous GeneCards Identifiers for RSC1A1 Gene

  • GC01P015342
  • GC01P015123
  • GC01P015232
  • GC01P015349
  • GC01P015307
  • GC01P015731
  • GC01P015817
  • GC01P015986
  • GC01P014505

Summaries for RSC1A1 Gene

GeneCards Summary for RSC1A1 Gene

RSC1A1 (Regulatory Solute Carrier Protein, Family 1, Member 1) is a Protein Coding gene. GO annotations related to this gene include ion channel inhibitor activity.

UniProtKB/Swiss-Prot for RSC1A1 Gene

  • Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSC1A1 Gene

Genomics for RSC1A1 Gene

Regulatory Elements for RSC1A1 Gene

Genomic Location for RSC1A1 Gene

Start:
15,659,869 bp from pter
End:
15,661,722 bp from pter
Size:
1,854 bases
Orientation:
Plus strand

Genomic View for RSC1A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RSC1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSC1A1 Gene

Proteins for RSC1A1 Gene

  • Protein details for RSC1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92681-RSCA1_HUMAN
    Recommended name:
    Regulatory solute carrier protein family 1 member 1
    Protein Accession:
    Q92681
    Secondary Accessions:
    • B2RBP5

    Protein attributes for RSC1A1 Gene

    Size:
    617 amino acids
    Molecular mass:
    66790 Da
    Quaternary structure:
    • Interacts with YRDC.

neXtProt entry for RSC1A1 Gene

Proteomics data for RSC1A1 Gene at MOPED

Post-translational modifications for RSC1A1 Gene

  • Ubiquitination at Lys512 and Lys522
  • Modification sites at PhosphoSitePlus

Other Protein References for RSC1A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RSC1A1 Gene

Domains for RSC1A1 Gene

Protein Domains for RSC1A1 Gene

Suggested Antigen Peptide Sequences for RSC1A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92681

UniProtKB/Swiss-Prot:

RSCA1_HUMAN :
  • Q92681
Domain:
  • The tripeptides QCP and QSP mediate post-transcriptional down-regulation of SLC5A1 at the trans-Golgi network. They inhibit a monosaccharide-dependent exocytotic pathway of SLC5A1.
  • Contains 1 UBA domain.
genes like me logo Genes that share domains with RSC1A1: view

No data available for Gene Families for RSC1A1 Gene

Function for RSC1A1 Gene

Molecular function for RSC1A1 Gene

GENATLAS Biochemistry: regulatory solute carrier protein family 1,member 1,membrane-associated modulator of the sodium-glucose cotransport system
UniProtKB/Swiss-Prot Function: Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network.

Gene Ontology (GO) - Molecular Function for RSC1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008200 ion channel inhibitor activity TAS 8836035
genes like me logo Genes that share ontologies with RSC1A1: view
genes like me logo Genes that share phenotypes with RSC1A1: view

Animal Models for RSC1A1 Gene

MGI Knock Outs for RSC1A1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RSC1A1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RSC1A1 Gene

Localization for RSC1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RSC1A1 Gene

Cell membrane. Nucleus. Golgi apparatus, trans-Golgi network. Note=Localizes at the inner side of the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RSC1A1 Gene COMPARTMENTS Subcellular localization image for RSC1A1 gene
Compartment Confidence
nucleus 5
plasma membrane 5
golgi apparatus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for RSC1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane IDA --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with RSC1A1: view

Pathways for RSC1A1 Gene

SuperPathways for RSC1A1 Gene

No Data Available

Interacting Proteins for RSC1A1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000341963%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000249299%0d%0a
Selected Interacting proteins: ENSP00000341963 Q92681-RSCA1_HUMAN for RSC1A1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for RSC1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006810 transport TAS 8836035
GO:0051051 negative regulation of transport IDA 2675563
genes like me logo Genes that share ontologies with RSC1A1: view

No data available for Pathways by source for RSC1A1 Gene

Compounds for RSC1A1 Gene

(1) Novoseek inferred chemical compound relationships for RSC1A1 Gene

Compound -log(P) Hits PubMed IDs
glucose 10.4 3
genes like me logo Genes that share compounds with RSC1A1: view

Transcripts for RSC1A1 Gene

mRNA/cDNA for RSC1A1 Gene

(39) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RSC1A1 Gene

Regulatory solute carrier protein, family 1, member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RSC1A1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RSC1A1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RSC1A1 Gene

No ASD Table

Relevant External Links for RSC1A1 Gene

GeneLoc Exon Structure for
RSC1A1
ECgene alternative splicing isoforms for
RSC1A1

Expression for RSC1A1 Gene

mRNA expression in normal human tissues for RSC1A1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RSC1A1 Gene

SOURCE GeneReport for Unigene cluster for RSC1A1 Gene Hs.239459

mRNA Expression by UniProt/SwissProt for RSC1A1 Gene

Q92681-RSCA1_HUMAN
Tissue specificity: Expressed in small intestine, kidney and brain.
genes like me logo Genes that share expressions with RSC1A1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RSC1A1 Gene

Orthologs for RSC1A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RSC1A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RSC1A1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RSC1A1 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RSC1A1 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rsc1a1 35
  • 73.42 (n)
  • 58.25 (a)
Rsc1a1 16
Rsc1a1 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RSC1A1 36
  • 46 (a)
OneToOne
Species with no ortholog for RSC1A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RSC1A1 Gene

ENSEMBL:
Gene Tree for RSC1A1 (if available)
TreeFam:
Gene Tree for RSC1A1 (if available)

Paralogs for RSC1A1 Gene

Pseudogenes.org Pseudogenes for RSC1A1 Gene

genes like me logo Genes that share paralogs with RSC1A1: view

No data available for Paralogs for RSC1A1 Gene

Variants for RSC1A1 Gene

Sequence variations from dbSNP and Humsavar for RSC1A1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs10492986 -- 15,662,207(+) TAATT(C/T)GGTGT downstream-variant-500B
rs10927821 -- 15,662,204(+) ACATA(A/G)TTTGG downstream-variant-500B
rs58186615 -- 15,661,863(+) TTTTT(-/T)AAAGA downstream-variant-500B
rs115681836 -- 15,661,864(+) TTTTT(A/T)AAGAT downstream-variant-500B
rs118187152 -- 15,661,707(+) AACAT(C/T)GTAGT reference, synonymous-codon

Relevant External Links for RSC1A1 Gene

HapMap Linkage Disequilibrium report
RSC1A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RSC1A1 Gene

Disorders for RSC1A1 Gene

Relevant External Links for RSC1A1

Genetic Association Database (GAD)
RSC1A1
Human Genome Epidemiology (HuGE) Navigator
RSC1A1
genes like me logo Genes that share disorders with RSC1A1: view

No data available for UniProtKB/Swiss-Prot for RSC1A1 Gene

Publications for RSC1A1 Gene

  1. Downregulation of the Na(+)- D-glucose cotransporter SGLT1 by protein RS1 (RSC1A1) is dependent on dynamin and protein kinase C. (PMID: 14724758) Veyhl M. … Koepsell H. (J. Membr. Biol. 2003) 3 4 23
  2. RS1 (RSC1A1) regulates the exocytotic pathway of Na+-D-glucose cotransporter SGLT1. (PMID: 16788146) Veyhl M. … Koepsell H. (Am. J. Physiol. 2006) 3 4 23
  3. Transporter regulator RS1 (RSC1A1) coats the trans-Golgi network and migrates into the nucleus. (PMID: 16788147) Kroiss M. … Koepsell H. (Am. J. Physiol. 2006) 3 4 23
  4. The human gene of a protein that modifies Na(+)-D-glucose co- transport. (PMID: 8836035) Lambotte S. … Koepsell H. (DNA Cell Biol. 1996) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for RSC1A1 Gene

Sources for RSC1A1 Gene

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