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Aliases for RSC1A1 Gene

Aliases for RSC1A1 Gene

  • Regulator Of Solute Carriers 1 2 3 5
  • Regulatory Solute Carrier Protein, Family 1, Member 1 2 3
  • Transporter Regulator RS1 3 4
  • Regulatory Solute Carrier Protein Family 1 Member 1 3
  • HRS1 4
  • RS1 3

External Ids for RSC1A1 Gene

Previous GeneCards Identifiers for RSC1A1 Gene

  • GC01P015342
  • GC01P015123
  • GC01P015232
  • GC01P015349
  • GC01P015307
  • GC01P015731
  • GC01P015817
  • GC01P015986
  • GC01P014505

Summaries for RSC1A1 Gene

Entrez Gene Summary for RSC1A1 Gene

  • The protein encoded by this intronless gene inhibits the expression of the solute carrier family 5 (sodium/glucose cotransporter), member 1 gene (SLC5A1) and downregulates exocytosis of the SLC5A1 protein. The encoded protein is sometimes found coating the trans-Golgi network and other times is localized to the nucleus, depending on the cell cycle stage. This protein also inhibits the expression of solute carrier family 22 (organic cation transporter), member 2 (SLC22A2). [provided by RefSeq, Dec 2015]

GeneCards Summary for RSC1A1 Gene

RSC1A1 (Regulator Of Solute Carriers 1) is a Protein Coding gene. Among its related pathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include ion channel inhibitor activity.

UniProtKB/Swiss-Prot for RSC1A1 Gene

  • Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSC1A1 Gene

Genomics for RSC1A1 Gene

Regulatory Elements for RSC1A1 Gene

Enhancers for RSC1A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F015629 0.2 ENCODE 11.8 -29.6 -29553 1.1 JUND KLF17 PRDM10 ZNF623 SLC25A34 RSC1A1 PLEKHM2 RNU7-179P ENSG00000237938 ENSG00000251866 FBLIM1 AGMAT DDI2 GC01P015660
GH01F015627 0.2 ENCODE 11.8 -32.1 -32111 1.4 HDGF PKNOX1 ARNT FEZF1 ZNF2 ZNF121 ZNF263 TSHZ1 REST SMARCA4 PLEKHM2 RSC1A1 ENSG00000251866 FBLIM1 DDI2 PIR39170 GC01P015660
GH01F015696 1.3 Ensembl ENCODE 11.5 +37.7 37732 2.4 TBP PKNOX1 TBL1XR1 WRNIP1 SIN3A BMI1 ZNF121 EGR1 ELK1 ETV6 ENSG00000237938 SLC25A34 RSC1A1 FBLIM1 RNU7-179P ENSG00000251866 PLEKHM2 ENSG00000272510 FAM131C PIR54516
GH01F015716 0.2 ENCODE 10.7 +57.9 57929 2.5 ZNF121 HIC1 GLIS2 KDM1A ZIC2 NR2F2 PLEKHM2 SLC25A34 FBLIM1 RSC1A1 ENSG00000251866 PIR54516
GH01F015563 0.2 Ensembl 10.5 -95.8 -95769 0.6 ADNP ZNF384 BCL11B ENSG00000251866 RSC1A1 ENSG00000272510 PIR43250
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RSC1A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RSC1A1 Gene

Chromosome:
1
Start:
15,659,869 bp from pter
End:
15,661,722 bp from pter
Size:
1,854 bases
Orientation:
Plus strand

Genomic View for RSC1A1 Gene

Genes around RSC1A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RSC1A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RSC1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSC1A1 Gene

Proteins for RSC1A1 Gene

  • Protein details for RSC1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92681-RSCA1_HUMAN
    Recommended name:
    Regulatory solute carrier protein family 1 member 1
    Protein Accession:
    Q92681
    Secondary Accessions:
    • B2RBP5

    Protein attributes for RSC1A1 Gene

    Size:
    617 amino acids
    Molecular mass:
    66790 Da
    Quaternary structure:
    • Interacts with YRDC.

neXtProt entry for RSC1A1 Gene

Post-translational modifications for RSC1A1 Gene

  • Ubiquitination at Lys 512 and Lys 522
  • Modification sites at PhosphoSitePlus

Other Protein References for RSC1A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RSC1A1 Gene

Domains & Families for RSC1A1 Gene

Protein Domains for RSC1A1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RSC1A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92681

UniProtKB/Swiss-Prot:

RSCA1_HUMAN :
  • The tripeptides QCP and QSP mediate post-transcriptional down-regulation of SLC5A1 at the trans-Golgi network. They inhibit a monosaccharide-dependent exocytotic pathway of SLC5A1.
Domain:
  • The tripeptides QCP and QSP mediate post-transcriptional down-regulation of SLC5A1 at the trans-Golgi network. They inhibit a monosaccharide-dependent exocytotic pathway of SLC5A1.
  • Contains 1 UBA domain.
genes like me logo Genes that share domains with RSC1A1: view

No data available for Gene Families for RSC1A1 Gene

Function for RSC1A1 Gene

Molecular function for RSC1A1 Gene

GENATLAS Biochemistry:
regulatory solute carrier protein family 1,member 1,membrane-associated modulator of the sodium-glucose cotransport system
UniProtKB/Swiss-Prot Function:
Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network.

Gene Ontology (GO) - Molecular Function for RSC1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008200 ion channel inhibitor activity TAS 8836035
genes like me logo Genes that share ontologies with RSC1A1: view
genes like me logo Genes that share phenotypes with RSC1A1: view

Animal Models for RSC1A1 Gene

MGI Knock Outs for RSC1A1:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RSC1A1 Gene

Localization for RSC1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RSC1A1 Gene

Cell membrane. Nucleus. Golgi apparatus, trans-Golgi network. Note=Localizes at the inner side of the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RSC1A1 Gene COMPARTMENTS Subcellular localization image for RSC1A1 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RSC1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RSC1A1: view

Pathways & Interactions for RSC1A1 Gene

genes like me logo Genes that share pathways with RSC1A1: view

Interacting Proteins for RSC1A1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000341963%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000249299%0d%0a
Selected Interacting proteins: ENSP00000341963 Q92681-RSCA1_HUMAN for RSC1A1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for RSC1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006810 transport TAS 8836035
GO:0051051 negative regulation of transport IDA 2675563
genes like me logo Genes that share ontologies with RSC1A1: view

No data available for SIGNOR curated interactions for RSC1A1 Gene

Drugs & Compounds for RSC1A1 Gene

(1) Drugs for RSC1A1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RSC1A1: view

Transcripts for RSC1A1 Gene

mRNA/cDNA for RSC1A1 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(39) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RSC1A1 Gene

Regulatory solute carrier protein, family 1, member 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RSC1A1 Gene

No ASD Table

Relevant External Links for RSC1A1 Gene

GeneLoc Exon Structure for
RSC1A1
ECgene alternative splicing isoforms for
RSC1A1

Expression for RSC1A1 Gene

mRNA expression in normal human tissues for RSC1A1 Gene

Protein differential expression in normal tissues from HIPED for RSC1A1 Gene

This gene is overexpressed in Plasma (36.4) and Urine (32.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RSC1A1 Gene



Protein tissue co-expression partners for RSC1A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RSC1A1 Gene:

RSC1A1

SOURCE GeneReport for Unigene cluster for RSC1A1 Gene:

Hs.239459

mRNA Expression by UniProt/SwissProt for RSC1A1 Gene:

Q92681-RSCA1_HUMAN
Tissue specificity: Expressed in small intestine, kidney and brain.
genes like me logo Genes that share expression patterns with RSC1A1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RSC1A1 Gene

Orthologs for RSC1A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RSC1A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RSC1A1 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RSC1A1 35
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rsc1a1 34 16 35
  • 73.42 (n)
dog
(Canis familiaris)
Mammalia RSC1A1 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RSC1A1 35
  • 46 (a)
OneToOne
Species where no ortholog for RSC1A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RSC1A1 Gene

ENSEMBL:
Gene Tree for RSC1A1 (if available)
TreeFam:
Gene Tree for RSC1A1 (if available)

Paralogs for RSC1A1 Gene

Pseudogenes.org Pseudogenes for RSC1A1 Gene

genes like me logo Genes that share paralogs with RSC1A1: view

No data available for Paralogs for RSC1A1 Gene

Variants for RSC1A1 Gene

Sequence variations from dbSNP and Humsavar for RSC1A1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10492986 -- 15,662,207(+) TAATT(C/T)GGTGT downstream-variant-500B
rs10927821 -- 15,662,204(+) ACATA(A/G)TTTGG downstream-variant-500B
rs113181310 -- 15,660,028(+) CTGTG(A/G)AGGCT reference, missense, utr-variant-3-prime
rs113570905 -- 15,659,566(+) ACCCC(A/G)CCATT intron-variant, upstream-variant-2KB
rs114315704 -- 15,658,776(+) TCTTA(C/G)ACTTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RSC1A1 Gene

Variant ID Type Subtype PubMed ID
nsv1006877 CNV gain 25217958

Variation tolerance for RSC1A1 Gene

Residual Variation Intolerance Score: 94.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.68; 82.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RSC1A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RSC1A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSC1A1 Gene

Disorders for RSC1A1 Gene

Relevant External Links for RSC1A1

Genetic Association Database (GAD)
RSC1A1
Human Genome Epidemiology (HuGE) Navigator
RSC1A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RSC1A1

No disorders were found for RSC1A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RSC1A1 Gene

Publications for RSC1A1 Gene

  1. RS1 (RSC1A1) regulates the exocytotic pathway of Na+-D-glucose cotransporter SGLT1. (PMID: 16788146) Veyhl M. … Koepsell H. (Am. J. Physiol. 2006) 3 4 22 64
  2. Transporter regulator RS1 (RSC1A1) coats the trans-Golgi network and migrates into the nucleus. (PMID: 16788147) Kroiss M. … Koepsell H. (Am. J. Physiol. 2006) 3 4 22 64
  3. Downregulation of the Na(+)- D-glucose cotransporter SGLT1 by protein RS1 (RSC1A1) is dependent on dynamin and protein kinase C. (PMID: 14724758) Veyhl M. … Koepsell H. (J. Membr. Biol. 2003) 3 4 22 64
  4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
  5. Novel shuttling domain in a regulator (RSC1A1) of transporter SGLT1 steers cell cycle-dependent nuclear location. (PMID: 19765263) Filatova A. … Koepsell H. (Traffic 2009) 3 22 64

Products for RSC1A1 Gene

Sources for RSC1A1 Gene

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