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Aliases for RSBN1L Gene

Aliases for RSBN1L Gene

  • Round Spermatid Basic Protein 1 Like 2 3 5
  • Round Spermatid Basic Protein 1-Like 2

External Ids for RSBN1L Gene

Previous GeneCards Identifiers for RSBN1L Gene

  • GC07P076970
  • GC07P077163
  • GC07P077325
  • GC07P071928

Summaries for RSBN1L Gene

GeneCards Summary for RSBN1L Gene

RSBN1L (Round Spermatid Basic Protein 1 Like) is a Protein Coding gene. An important paralog of this gene is RSBN1.

Additional gene information for RSBN1L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSBN1L Gene

Genomics for RSBN1L Gene

Regulatory Elements for RSBN1L Gene

Enhancers for RSBN1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H077796 1.5 FANTOM5 ENCODE 46.6 +102.5 102501 4 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SPDYE18 RSBN1L FAM185BP SPDYE17 APTR PMS2P9 LOC100422695 CCDC146 DTX2P1 ENSG00000250990
GH07H077695 1.1 ENCODE 30.7 +1.2 1168 4 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 APTR SPDYE18 RSBN1L PMS2P9 TMEM60 DTX2P1 FAM185BP SPDYE17 PHTF2 PTPN12
GH07H077535 1.4 ENCODE dbSUPER 23.6 -157.9 -157925 5 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 PTPN12 APTR RSBN1L DTX2P1 PMS2P9 FAM185BP POMZP3 CCDC146 LOC105375363
GH07H077530 1.2 Ensembl ENCODE dbSUPER 17 -165.5 -165493 1 PKNOX1 ELF1 DPF2 ZBTB40 GABPA RELA ZNF592 SNIP1 NCOR1 PHB2 APTR RSBN1L SPDYE17 SPDYE18 PMS2P9 CCDC146 DTX2P1 FAM185BP GC07M077535 PIR61362
GH07H077121 1.1 ENCODE 11.5 -574.2 -574150 1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 SPDYE18 SPDYE17 ENSG00000213542 POMZP3 RSBN1L CCDC146 UPK3B GC07M077212 FAM185BP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RSBN1L on UCSC Golden Path with GeneCards custom track

Promoters for RSBN1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000214080 74 4201 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for RSBN1L Gene

Chromosome:
7
Start:
77,696,426 bp from pter
End:
77,783,022 bp from pter
Size:
86,597 bases
Orientation:
Plus strand

Genomic View for RSBN1L Gene

Genes around RSBN1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RSBN1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RSBN1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSBN1L Gene

Proteins for RSBN1L Gene

  • Protein details for RSBN1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PCB5-RSBNL_HUMAN
    Recommended name:
    Round spermatid basic protein 1-like protein
    Protein Accession:
    Q6PCB5
    Secondary Accessions:
    • C9K0P1
    • Q6ZS58
    • Q6ZVI9
    • Q86X48

    Protein attributes for RSBN1L Gene

    Size:
    846 amino acids
    Molecular mass:
    94870 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH46353.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAC85872.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RSBN1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RSBN1L Gene

Post-translational modifications for RSBN1L Gene

  • Ubiquitination at isoforms=2548
  • Modification sites at PhosphoSitePlus

Other Protein References for RSBN1L Gene

No data available for DME Specific Peptides for RSBN1L Gene

Domains & Families for RSBN1L Gene

Gene Families for RSBN1L Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for RSBN1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RSBN1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PCB5

UniProtKB/Swiss-Prot:

RSBNL_HUMAN :
  • Belongs to the round spermatid basic protein 1 family.
Family:
  • Belongs to the round spermatid basic protein 1 family.
genes like me logo Genes that share domains with RSBN1L: view

Function for RSBN1L Gene

Phenotypes From GWAS Catalog for RSBN1L Gene

genes like me logo Genes that share phenotypes with RSBN1L: view

Animal Model Products

CRISPR Products

miRNA for RSBN1L Gene

miRTarBase miRNAs that target RSBN1L

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RSBN1L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RSBN1L Gene

Localization for RSBN1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for RSBN1L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RSBN1L gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RSBN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with RSBN1L: view

Pathways & Interactions for RSBN1L Gene

SuperPathways for RSBN1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for RSBN1L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RSBN1L Gene

Drugs & Compounds for RSBN1L Gene

No Compound Related Data Available

Transcripts for RSBN1L Gene

Unigene Clusters for RSBN1L Gene

Round spermatid basic protein 1-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RSBN1L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RSBN1L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3:

Relevant External Links for RSBN1L Gene

GeneLoc Exon Structure for
RSBN1L
ECgene alternative splicing isoforms for
RSBN1L

Expression for RSBN1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RSBN1L Gene

Protein differential expression in normal tissues from HIPED for RSBN1L Gene

This gene is overexpressed in Lung (54.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RSBN1L Gene



Protein tissue co-expression partners for RSBN1L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RSBN1L Gene:

RSBN1L

SOURCE GeneReport for Unigene cluster for RSBN1L Gene:

Hs.592289

Evidence on tissue expression from TISSUES for RSBN1L Gene

  • Nervous system(4.3)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with RSBN1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RSBN1L Gene

Orthologs for RSBN1L Gene

This gene was present in the common ancestor of animals.

Orthologs for RSBN1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RSBN1L 33 34
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia RSBN1L 33 34
  • 94.51 (n)
cow
(Bos Taurus)
Mammalia RSBN1L 33 34
  • 92.17 (n)
oppossum
(Monodelphis domestica)
Mammalia RSBN1L 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RSBN1L 34
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rsbn1l 33 16 34
  • 85.62 (n)
rat
(Rattus norvegicus)
Mammalia Rsbn1l 33
  • 84.83 (n)
chicken
(Gallus gallus)
Aves RSBN1L 33 34
  • 81.94 (n)
lizard
(Anolis carolinensis)
Reptilia RSBN1L 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rsbn1l 33
  • 72.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10600 34
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dpy-21 34
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.789 34
  • 54 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8474 33
Species where no ortholog for RSBN1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RSBN1L Gene

ENSEMBL:
Gene Tree for RSBN1L (if available)
TreeFam:
Gene Tree for RSBN1L (if available)

Paralogs for RSBN1L Gene

Paralogs for RSBN1L Gene

(1) SIMAP similar genes for RSBN1L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RSBN1L: view

Variants for RSBN1L Gene

Sequence variations from dbSNP and Humsavar for RSBN1L Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000013903 -- 77,753,297(+) AGTAG(C/T)GTCTT intron-variant
rs1000136615 -- 77,714,652(+) CCCTA(A/G)ACATT intron-variant
rs1000158627 -- 77,750,476(+) ACTGA(A/G)GAAAT intron-variant
rs1000206422 -- 77,776,543(+) GATTA(A/G)CTTCT intron-variant
rs1000220392 -- 77,754,408(+) GATCT(A/G)TGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RSBN1L Gene

Variant ID Type Subtype PubMed ID
nsv1140809 CNV deletion 24896259
nsv365896 CNV insertion 16902084
nsv831039 CNV gain 17160897

Variation tolerance for RSBN1L Gene

Residual Variation Intolerance Score: 16.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RSBN1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RSBN1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSBN1L Gene

Disorders for RSBN1L Gene

Relevant External Links for RSBN1L

Genetic Association Database (GAD)
RSBN1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RSBN1L

No disorders were found for RSBN1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RSBN1L Gene

Publications for RSBN1L Gene

  1. New loci associated with kidney function and chronic kidney disease. (PMID: 20383146) Köttgen A … Fox CS (Nature genetics 2010) 3 45 60
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for RSBN1L Gene

Sources for RSBN1L Gene

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