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Aliases for RSBN1L Gene

Aliases for RSBN1L Gene

  • Round Spermatid Basic Protein 1 Like 2 3 5
  • Round Spermatid Basic Protein 1-Like 2

External Ids for RSBN1L Gene

Previous GeneCards Identifiers for RSBN1L Gene

  • GC07P076970
  • GC07P077163
  • GC07P077325
  • GC07P071928

Summaries for RSBN1L Gene

GeneCards Summary for RSBN1L Gene

RSBN1L (Round Spermatid Basic Protein 1 Like) is a Protein Coding gene. An important paralog of this gene is RSBN1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSBN1L Gene

Genomics for RSBN1L Gene

Regulatory Elements for RSBN1L Gene

Enhancers for RSBN1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G077759 1 Ensembl ENCODE 12.1 +63.2 63167 0.8 CTCF ARID4B CEBPG CHD7 RAD21 RFX5 ARID3A ZNF316 FOXK2 ZNF143 RSBN1L APTR TMEM60 PHTF2
GH07G077720 0.9 Ensembl ENCODE 13.3 +24.3 24302 0.7 ZNF362 ZNF146 ZNF394 OSR2 ZSCAN21 ZFHX2 GLIS1 ZNF629 ZNF600 PRDM10 APTR RSBN1L TMEM60 PHTF2 PTPN12
GH07G077718 0.5 Ensembl 13.3 +22.5 22475 0.2 ZNF335 SCRT2 ZBTB17 RSBN1L APTR PHTF2 TMEM60 PTPN12
GH07G077717 0.4 Ensembl 13.3 +21.5 21475 0.2 KLF1 RSBN1L APTR TMEM60 PHTF2 PTPN12
GH07G077719 0.2 Ensembl 13.3 +22.1 22075 0.2 RSBN1L APTR PHTF2 TMEM60 PTPN12
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RSBN1L on UCSC Golden Path with GeneCards custom track

Promoters for RSBN1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000214080 74 4201 HDGF PKNOX1 FOXA2 MLX ARNT AGO1 ZFP64 WRNIP1 ARID4B SIN3A

Genomic Location for RSBN1L Gene

Chromosome:
7
Start:
77,696,426 bp from pter
End:
77,783,022 bp from pter
Size:
86,597 bases
Orientation:
Plus strand

Genomic View for RSBN1L Gene

Genes around RSBN1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RSBN1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RSBN1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSBN1L Gene

Proteins for RSBN1L Gene

  • Protein details for RSBN1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PCB5-RSBNL_HUMAN
    Recommended name:
    Round spermatid basic protein 1-like protein
    Protein Accession:
    Q6PCB5
    Secondary Accessions:
    • C9K0P1
    • Q6ZS58
    • Q6ZVI9
    • Q86X48

    Protein attributes for RSBN1L Gene

    Size:
    846 amino acids
    Molecular mass:
    94870 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH46353.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAC85872.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RSBN1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RSBN1L Gene

Post-translational modifications for RSBN1L Gene

  • Ubiquitination at isoforms=2548
  • Modification sites at PhosphoSitePlus

Other Protein References for RSBN1L Gene

No data available for DME Specific Peptides for RSBN1L Gene

Domains & Families for RSBN1L Gene

Protein Domains for RSBN1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RSBN1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PCB5

UniProtKB/Swiss-Prot:

RSBNL_HUMAN :
  • Belongs to the round spermatid basic protein 1 family.
Family:
  • Belongs to the round spermatid basic protein 1 family.
genes like me logo Genes that share domains with RSBN1L: view

No data available for Gene Families for RSBN1L Gene

Function for RSBN1L Gene

genes like me logo Genes that share phenotypes with RSBN1L: view

Animal Model Products

CRISPR Products

miRNA for RSBN1L Gene

miRTarBase miRNAs that target RSBN1L

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RSBN1L Gene

Localization for RSBN1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for RSBN1L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RSBN1L gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for RSBN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with RSBN1L: view

Pathways & Interactions for RSBN1L Gene

SuperPathways for RSBN1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for RSBN1L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RSBN1L Gene

Drugs & Compounds for RSBN1L Gene

No Compound Related Data Available

Transcripts for RSBN1L Gene

Unigene Clusters for RSBN1L Gene

Round spermatid basic protein 1-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RSBN1L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3:

Relevant External Links for RSBN1L Gene

GeneLoc Exon Structure for
RSBN1L
ECgene alternative splicing isoforms for
RSBN1L

Expression for RSBN1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RSBN1L Gene

Protein differential expression in normal tissues from HIPED for RSBN1L Gene

This gene is overexpressed in Lung (54.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RSBN1L Gene



Protein tissue co-expression partners for RSBN1L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RSBN1L Gene:

RSBN1L

SOURCE GeneReport for Unigene cluster for RSBN1L Gene:

Hs.592289

Evidence on tissue expression from TISSUES for RSBN1L Gene

  • Nervous system(4.3)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with RSBN1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RSBN1L Gene

Orthologs for RSBN1L Gene

This gene was present in the common ancestor of animals.

Orthologs for RSBN1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RSBN1L 34 35
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia RSBN1L 34 35
  • 94.51 (n)
cow
(Bos Taurus)
Mammalia RSBN1L 34 35
  • 92.17 (n)
oppossum
(Monodelphis domestica)
Mammalia RSBN1L 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RSBN1L 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rsbn1l 34 16 35
  • 85.62 (n)
rat
(Rattus norvegicus)
Mammalia Rsbn1l 34
  • 84.83 (n)
chicken
(Gallus gallus)
Aves RSBN1L 34 35
  • 81.94 (n)
lizard
(Anolis carolinensis)
Reptilia RSBN1L 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rsbn1l 34
  • 72.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10600 35
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dpy-21 35
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.789 35
  • 54 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8474 34
Species where no ortholog for RSBN1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RSBN1L Gene

ENSEMBL:
Gene Tree for RSBN1L (if available)
TreeFam:
Gene Tree for RSBN1L (if available)

Paralogs for RSBN1L Gene

Paralogs for RSBN1L Gene

(1) SIMAP similar genes for RSBN1L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RSBN1L: view

Variants for RSBN1L Gene

Sequence variations from dbSNP and Humsavar for RSBN1L Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000013903 -- 77,753,297(+) AGTAG(C/T)GTCTT intron-variant
rs1000136615 -- 77,714,652(+) CCCTA(A/G)ACATT intron-variant
rs1000158627 -- 77,750,476(+) ACTGA(A/G)GAAAT intron-variant
rs1000206422 -- 77,776,543(+) GATTA(A/G)CTTCT intron-variant
rs1000220392 -- 77,754,408(+) GATCT(A/G)TGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RSBN1L Gene

Variant ID Type Subtype PubMed ID
nsv1140809 CNV deletion 24896259
nsv365896 CNV insertion 16902084
nsv831039 CNV gain 17160897

Variation tolerance for RSBN1L Gene

Residual Variation Intolerance Score: 16.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RSBN1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RSBN1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSBN1L Gene

Disorders for RSBN1L Gene

Relevant External Links for RSBN1L

Genetic Association Database (GAD)
RSBN1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RSBN1L

No disorders were found for RSBN1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RSBN1L Gene

Publications for RSBN1L Gene

  1. New loci associated with kidney function and chronic kidney disease. (PMID: 20383146) KAPttgen A. … Fox C.S. (Nat. Genet. 2010) 3 46 64
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for RSBN1L Gene

Sources for RSBN1L Gene

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