RSBN1 Gene
protein-coding GIFtS: 45
GCID: GC01M114304
|
|
round spermatid basic protein 1
| |
Aliases
for RSBN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Round Spermatid Basic Protein 11 2 | | ROSBIN1 2 | | FLJ112201 | | RP11-324J2.12 |
Export aliases for RSBN1 gene to outside databasesPrevious GC identifers: GC01M114019 GC01M114105 GC01M112162 |
Summaries
for RSBN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RSBN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RSBN1 gene promoter:
AhR STAT1 STAT1beta LUN-1 LCR-F1 GATA-2 STAT1alpha Egr-4 COMP1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for RSBN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RSBN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p13.2 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p13.1RSBN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M114304: view genomic region
(about GC identifiers)
Start:
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114,304,454 bp from pter |
End:
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114,355,098 bp from pter |
Size:
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50,645 bases |
Orientation:
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minus strand |
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Proteins
for RSBN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RSBN1_HUMAN, Q5VWQ0 (See
protein sequence)Recommended Name: Round spermatid basic protein 1 Size: 802 amino acids; 90072 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAH26155.1; Type=Erroneous initiation; Sequence=BAA92075.1; Type=Erroneous initiation;Sequence=BAB13974.1; Type=Erroneous initiation; Sequence=CAH10493.1; Type=Erroneous initiation; Note=TranslationN-terminally extended; Sequence=CAH10493.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;Sequence=CAH72507.1; Type=Erroneous initiation; Sequence=CAI19067.1; Type=Erroneous initiation;
Secondary accessions: A8K937 Q6AI21 Q8TC33 Q9HA80 Q9NUP6Alternative splicing: 2 isoforms: Q5VWQ0-1 Q5VWQ0-4 Explore the universe of human proteins at neXtProt for RSBN1: NX_Q5VWQ0
Post-translational modifications:
Phosphorylated by PKA (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5VWQ0
RSBN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060834.2
ENSEMBL proteins: ENSP00000261441 ENSP00000433256
Human Recombinant Protein Products for RSBN1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
RSBN1 for ontologies About GeneDecksing
RSBN1 Antibody Products:
Assay Products for RSBN1: |
Protein
Domains /
Families
for RSBN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RSBN1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5VWQ0ProtoNet protein and cluster: Q5VWQ0 UniProtKB/Swiss-Prot: RSBN1_HUMAN, Q5VWQ0Similarity: Belongs to the round spermatid basic protein 1 family |
Function
for RSBN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- |
RSBN1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for RSBN1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RSBN1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RSBN1 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RSBN1 (NM_018364) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RSBN1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSBN1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSBN1 |
|
Pathways & Interactions
for RSBN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RSBN1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/9 Interacting proteins for RSBN1 (Q5VWQ03 ENSP000002614414) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
|
Drugs & Compounds
for RSBN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RSBN1
Search CenterWatch for drugs/clinical trials and news about RSBN1
|
Transcripts
for RSBN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RSBN1 gene: NM_018364.3 Unigene Cluster for RSBN1: Round spermatid basic protein 1 Hs.486285 [show with all ESTs]Unigene Representative Sequence: NM_0183643 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000261441(uc001edq.3 uc001edr.3) ENST00000476412 ENST00000369581
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RSBN1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RSBN1 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RSBN1 (NM_018364) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RSBN1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSBN1 |
Additional cDNA sequence: AK002082.1 AK022166.1 AK292552.1 AL050064.1 BC026155.1 CR627402.1 12 DOTS entries: DT.413026 DT.444261 DT.40124692 DT.121428295 DT.97841952 DT.121428239 DT.121428243 DT.91695050 DT.95281752 DT.121428268 DT.95259516 DT.95265395 24/135 AceView cDNA sequences (see all 135): AA382923 BC026155 BE044188 AI261745 AI825693 BX478083 AI696509 AI075979 CF527941 AU121374 CR627402 AA504548 BF110125 AW467256 BQ694562 AU133932 CA432709 BE301435 AA382924 AW134518 BE888593 AI365485 AI768601 AA995184
GeneLoc Exon Structure
|
Expression
for RSBN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RSBN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RSBN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RSBN1
SOURCE GeneReport for Unigene cluster: Hs.486285
SABiosciences Custom PCR Arrays for RSBN1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RSBN1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RSBN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RSBN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RSBN1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSBN1 |
Orthologs
for RSBN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RSBN1 gene from 7/20 species (see all 20) About this table
ENSEMBL Gene Tree for RSBN1 (if available)
TreeFam Gene Tree for RSBN1 (if available) |
Paralogs
for RSBN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RSBN1 gene
- RSBN1L2
1 SIMAP similar gene for RSBN1 using alignment to 2 protein entries: RSBN1_HUMAN (see all proteins):RSBN1L
RSBN1 for paralogs About GeneDecksing
|
Genomic Variants
for RSBN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RSBN1 (114304454 - 114355098 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for RSBN1
4 CNVs: 97473 2322 3306 64644
1 Indel: 58324 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RSBN1 |
|
Disorders
/ Diseases
for RSBN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RSBN1 for disorders About GeneDecksing
2  diseases for RSBN1: About MalaCardshermaphroditism arthritis
Human Genome Epidemiology (HuGE) Navigator: RSBN1 (3 documents)
Export disorders for RSBN1 gene to outside databases
|
Publications
for RSBN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RSBN1 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with RSBN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes. (PubMed id 18305142)1, 9 Smyth D.J....Todd J.A. (2008)
- Novel associations for hypothyroidism include known au toimmune risk loci. (PubMed id 22493691)1 Eriksson N....Do C.B. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Variants in TNFAIP3, STAT4, and C12orf30 loci associa ted with multiple autoimmune diseases are also associated with juvenile idiopat hic arthritis. (PubMed id 19565500)1 Prahalad S....Jorde L.B. (2009)
|
External Searches for RSBN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RSBN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RSBN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RSBN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RSBN1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RSBN1 gene:
Search GeneIP for patents involving RSBN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RSBN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RSBN1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RSBN1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RSBN1 | | | OriGene Protein Over-expression Lysate for RSBN1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RSBN1 | | OriGene 3'-UTR Clone for RSBN1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RSBN1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RSBN1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RSBN1 | | OriGene Custom Protein Services for RSBN1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RSBN1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RSBN1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RSBN1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RSBN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RSBN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RSBN1 |
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 |  |  |  | |
| | | | Search Tocris compounds for RSBN1 |
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 | | | RSBN1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSBN1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for RSBN1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSBN1 |
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