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Aliases for RSAD2 Gene

Aliases for RSAD2 Gene

  • Radical S-Adenosyl Methionine Domain Containing 2 2 3
  • Viperin 3 4 6
  • Virus Inhibitory Protein, Endoplasmic Reticulum-Associated, Interferon-Inducible 3 4
  • Cytomegalovirus-Induced Gene 5 Protein 3 4
  • Cig5 3 4
  • Radical S-Adenosyl Methionine Domain-Containing Protein 2 3
  • 2510004L01Rik 3
  • Cig33 3
  • Vig1 3

External Ids for RSAD2 Gene

Summaries for RSAD2 Gene

GeneCards Summary for RSAD2 Gene

RSAD2 (Radical S-Adenosyl Methionine Domain Containing 2) is a Protein Coding gene. Among its related pathways are Influenza A. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding and protein self-association.

UniProtKB/Swiss-Prot for RSAD2 Gene

  • Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), and human immunodeficiency virus (HIV-1). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, through binding and inhibition of the enzyme farnesyl diphospate synthase (FPPS), which is essential for the biosynthesis of isoprenoid-derived lipids. Promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating Lys-63-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSAD2 Gene

Genomics for RSAD2 Gene

Genomic Location for RSAD2 Gene

Start:
6,865,806 bp from pter
End:
6,898,239 bp from pter
Size:
32,434 bases
Orientation:
Plus strand

Genomic View for RSAD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RSAD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSAD2 Gene

Regulatory Elements for RSAD2 Gene

Proteins for RSAD2 Gene

  • Protein details for RSAD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXG1-RSAD2_HUMAN
    Recommended name:
    Radical S-adenosyl methionine domain-containing protein 2
    Protein Accession:
    Q8WXG1
    Secondary Accessions:
    • Q8WVI4

    Protein attributes for RSAD2 Gene

    Size:
    361 amino acids
    Molecular mass:
    42170 Da
    Cofactor:
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.;
    Quaternary structure:
    • Homodimer. Interacts with IRAK1 and TRAF6 (By similarity). Interacts with FPPS. Interacts with human cytomegalovirus/HHV-5 protein vMIA/UL37; this interaction results in RSAD2/viperin relocalization from the endoplasmic reticulum to the mitochondria. Interacts with HADHB. Interacts (via C-terminus) with VAPA/VAP33 (via C-terminus) and inhibits its interaction with hepatitis virus C (HCV) protein NS5A.
    Miscellaneous:
    • Up-regulated in atherosclerosis. Latent viruses like HCMV may be involved in atherogenesis by initiating local inflammation. This may induce up-regulation of antiviral gene RSAD2, which modulates lipids synthesis, and thus could play a role in abnormal lipid accumulation leading to atherosclerosis

neXtProt entry for RSAD2 Gene

Proteomics data for RSAD2 Gene at MOPED

Post-translational modifications for RSAD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RSAD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RSAD2 Gene

Domains for RSAD2 Gene

Protein Domains for RSAD2 Gene

Suggested Antigen Peptide Sequences for RSAD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WXG1

UniProtKB/Swiss-Prot:

RSAD2_HUMAN
Domain:
  • The N-terminal region (1-42) is necessary for its localization to the endoplasmic reticulum membrane and lipid droplet:
    • Q8WXG1
Family:
  • Belongs to the radical SAM superfamily. RSAD2 family.:
    • Q8WXG1
genes like me logo Genes that share domains with RSAD2: view

No data available for Gene Families for RSAD2 Gene

Function for RSAD2 Gene

Molecular function for RSAD2 Gene

UniProtKB/Swiss-Prot Function: Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), and human immunodeficiency virus (HIV-1). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, through binding and inhibition of the enzyme farnesyl diphospate synthase (FPPS), which is essential for the biosynthesis of isoprenoid-derived lipids. Promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating Lys-63-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins.
UniProtKB/Swiss-Prot Induction: By interferon type I, type II and bacterial lipopolysaccharides (LPS). Little or no induction by IFNG/IFN-gamma is observed in monocytic cell lines. Induced by infection with hepatitis C virus, yellow fever virus and Sendai virus, presumably through type I interferon pathway. Induction by infection with human cytomegalovirus (HCMV), stomatitis virus (VSV), chikungunya virus (CHIKV), Japanese encephalitis virus (JEV) occurs independent of the IFN pathway.

Gene Ontology (GO) - Molecular Function for RSAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0005515 protein binding IPI 21527675
GO:0043621 protein self-association IDA 19074433
GO:0046872 metal ion binding IEA --
GO:0051536 iron-sulfur cluster binding --
genes like me logo Genes that share ontologies with RSAD2: view
genes like me logo Genes that share phenotypes with RSAD2: view

Animal Models for RSAD2 Gene

MGI Knock Outs for RSAD2:

miRNA for RSAD2 Gene

miRTarBase miRNAs that target RSAD2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RSAD2 Gene

Localization for RSAD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RSAD2 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus. Endoplasmic reticulum. Lipid droplet. Mitochondrion. Mitochondrion inner membrane. Mitochondrion outer membrane. Note=Infection with human cytomegalovirus (HCMV) causes relocation to the Golgi apparatus and to cytoplasmic vacuoles which also contain HCMV proteins glycoprotein B and pp28. Interaction with human cytomegalovirus/HHV-5 protein vMIA/UL37 results in its relocalization from the endoplasmic reticulum to the mitochondria.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RSAD2 Gene COMPARTMENTS Subcellular localization image for RSAD2 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
mitochondrion 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RSAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 21527675
GO:0005741 mitochondrial outer membrane IDA 21527675
GO:0005743 mitochondrial inner membrane IDA 21527675
GO:0005783 endoplasmic reticulum IDA 11752458
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with RSAD2: view

Pathways for RSAD2 Gene

SuperPathways for RSAD2 Gene

Superpath Contained pathways
1 Influenza A
genes like me logo Genes that share pathways with RSAD2: view

Pathways by source for RSAD2 Gene

1 KEGG pathway for RSAD2 Gene

Gene Ontology (GO) - Biological Process for RSAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0008152 metabolic process IEA --
GO:0009615 response to virus IDA 21957124
GO:0016032 viral process IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with RSAD2: view

Compounds for RSAD2 Gene

(2) HMDB Compounds for RSAD2 Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0

(1) Novoseek inferred chemical compound relationships for RSAD2 Gene

Compound -log(P) Hits PubMed IDs
poly(i-c) 68.6 3
genes like me logo Genes that share compounds with RSAD2: view

Transcripts for RSAD2 Gene

Unigene Clusters for RSAD2 Gene

Radical S-adenosyl methionine domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RSAD2 Gene

No ASD Table

Relevant External Links for RSAD2 Gene

GeneLoc Exon Structure for
RSAD2
ECgene alternative splicing isoforms for
RSAD2

Expression for RSAD2 Gene

mRNA expression in normal human tissues for RSAD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RSAD2 Gene

This gene is overexpressed in Brain - Substantia nigra (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RSAD2 Gene

SOURCE GeneReport for Unigene cluster for RSAD2 Gene Hs.17518

genes like me logo Genes that share expressions with RSAD2: view

No data available for mRNA Expression by UniProt/SwissProt for RSAD2 Gene

Orthologs for RSAD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RSAD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RSAD2 35
  • 99.63 (n)
  • 99.17 (a)
RSAD2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RSAD2 35
  • 80.7 (n)
  • 83.93 (a)
RSAD2 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RSAD2 35
  • 80.89 (n)
  • 84.49 (a)
RSAD2 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rsad2 35
  • 80.82 (n)
  • 84.92 (a)
Rsad2 16
Rsad2 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RSAD2 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RSAD2 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rsad2 35
  • 80.43 (n)
  • 84.55 (a)
chicken
(Gallus gallus)
Aves RSAD2 35
  • 76 (n)
  • 81.63 (a)
RSAD2 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RSAD2 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rsad2 35
  • 66.67 (n)
  • 70.55 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11692 35
zebrafish
(Danio rerio)
Actinopterygii Dr.5830 35
rsad2 35
  • 67.76 (n)
  • 73.65 (a)
rsad2 36
  • 70 (a)
OneToOne
Species with no ortholog for RSAD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RSAD2 Gene

ENSEMBL:
Gene Tree for RSAD2 (if available)
TreeFam:
Gene Tree for RSAD2 (if available)

Paralogs for RSAD2 Gene

No data available for Paralogs for RSAD2 Gene

Variants for RSAD2 Gene

Sequence variations from dbSNP and Humsavar for RSAD2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1045239 -- 6,897,043(+) AGCCA(A/T)GTCAC utr-variant-3-prime
rs1375336 -- 6,895,302(+) CCTTT(A/T)TTAAT intron-variant
rs1448881 -- 6,884,486(+) GAAAA(A/G)AGAAA intron-variant
rs1448882 -- 6,884,589(+) TCCTC(A/G)TGGTG intron-variant
rs1463153 -- 6,895,298(+) CAAGC(C/T)TTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RSAD2 Gene

Variant ID Type Subtype PubMed ID
nsv833326 CNV Loss 17160897
nsv2596 CNV Insertion 18451855

Relevant External Links for RSAD2 Gene

HapMap Linkage Disequilibrium report
RSAD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSAD2 Gene

Disorders for RSAD2 Gene

Relevant External Links for RSAD2

Genetic Association Database (GAD)
RSAD2
Human Genome Epidemiology (HuGE) Navigator
RSAD2
genes like me logo Genes that share disorders with RSAD2: view

No data available for UniProtKB/Swiss-Prot for RSAD2 Gene

Publications for RSAD2 Gene

  1. Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus. (PMID: 11752458) Chin K.-C. … Cresswell P. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 23
  2. The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents. (PMID: 15890971) Olofsson P.S. … Sirsjoe A. (Arterioscler. Thromb. Vasc. Biol. 2005) 3 4 23
  3. Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector. (PMID: 16108059) Helbig K.J. … Beard M.R. (Hepatology 2005) 3 4 23
  4. Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1. (PMID: 16849320) Severa M. … Fitzgerald K.A. (J. Biol. Chem. 2006) 3 4 23
  5. TLR3 ligation activates an antiviral response in human fetal astrocytes: a role for viperin/cig5. (PMID: 16982913) Rivieccio M.A. … Brosnan C.F. (J. Immunol. 2006) 3 4 23

Products for RSAD2 Gene

Sources for RSAD2 Gene

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