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RSAD2 Gene

protein-coding   GIFtS: 56
GCID: GC02P007005

Radical S-Adenosyl Methionine Domain Containing 2

  Search for RSAD2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Radical S-Adenosyl Methionine Domain Containing 21 2     Radical S-Adenosyl Methionine Domain-Containing Protein 22
Cytomegalovirus-Induced Gene 5 Protein2 3     vig12
Virus Inhibitory Protein, Endoplasmic Reticulum-Associated,
Interferon-Inducible2 3
     viperin2
2510004L01Rik2     CIG53
cig332     Viperin3
cig52     VIPERIN5

External Ids:    HGNC: 309081   Entrez Gene: 915432   Ensembl: ENSG000001343217   OMIM: 6078105   UniProtKB: Q8WXG13   

Export aliases for RSAD2 gene to outside databases

Previous GC identifers: GC02P006969 GC02P006865


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RSAD2 Gene:
RSAD2 (radical S-adenosyl methionine domain containing 2) is a protein-coding gene. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding and protein self-association.

UniProtKB/Swiss-Prot: RSAD2_HUMAN, Q8WXG1
Function: Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in
the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA
viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus,
sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), and human immunodeficiency
virus (HIV-1). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from
the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, through binding and
inhibition of the enzyme farnesyl diphospate synthase (FPPS), which is essential for the biosynthesis of
isoprenoid-derived lipids. Promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid
dendritic cells (pDCs) by facilitating Lys-63'-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cells
activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T helper
2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005334.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the RSAD2 gene promoter:
         NF-1   NF-1/L   STAT5A   NF-kappaB   GATA-1   c-Ets-1   AREB6   HEN1   Sox9   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRSAD2 promoter sequence
   Search Chromatin IP Primers for RSAD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RSAD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.2   Ensembl cytogenetic band:  2p25.2   HGNC cytogenetic band: 2p25.2

RSAD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RSAD2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P007005:  view genomic region     (about GC identifiers)

Start:
7,005,937 bp from pter      End:
7,038,370 bp from pter
Size:
32,434 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RSAD2_HUMAN, Q8WXG1 (See protein sequence)
Recommended Name: Radical S-adenosyl methionine domain-containing protein 2  
Size: 361 amino acids; 42170 Da
Cofactor: Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable
S-adenosyl-L-methionine
Subunit: Homodimer. Interacts with IRAK1 and TRAF6 (By similarity). Interacts with FPPS. Interacts with human
cytomegalovirus/HHV-5 protein vMIA/UL37; this interaction results in RSAD2/viperin relocalization from the
endoplasmic reticulum to the mitochondria. Interacts with HADHB. Interacts (via C-terminus) with VAPA/VAP33 (via
C-terminus) and inhibits its interaction with hepatitis virus C (HCV) protein NS5A
Miscellaneous: Up-regulated in atherosclerosis. Latent viruses like HCMV may be involved in atherogenesis by
initiating local inflammation. This may induce up-regulation of antiviral gene RSAD2, which modulates lipids
synthesis, and thus could play a role in abnormal lipid accumulation leading to atherosclerosis
Secondary accessions: Q8WVI4

Explore the universe of human proteins at neXtProt for RSAD2: NX_Q8WXG1

Explore proteomics data for RSAD2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RSAD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_542388.2  
    ENSEMBL proteins: 
     ENSP00000406427   ENSP00000371471   ENSP00000440859  

    RSAD2 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for RSAD2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR013785 Aldolase_TIM
     IPR007197 rSAM
     IPR026372 Viperin
     IPR006638 Elp3/MiaB/NifB

    Graphical View of Domain Structure for InterPro Entry Q8WXG1

    ProtoNet protein and cluster: Q8WXG1

    1 Blocks protein domain: IPB006638 Elongator protein 3/MiaB/NifB

    UniProtKB/Swiss-Prot: RSAD2_HUMAN, Q8WXG1
    Domain: The N-terminal region (1-42) is necessary for its localization to the endoplasmic reticulum membrane and
    lipid droplet
    Similarity: Belongs to the radical SAM superfamily. RSAD2 family


    Find genes that share domains with RSAD2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RSAD2_HUMAN, Q8WXG1
    Function: Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in
    the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA
    viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus,
    sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), and human immunodeficiency
    virus (HIV-1). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from
    the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, through binding and
    inhibition of the enzyme farnesyl diphospate synthase (FPPS), which is essential for the biosynthesis of
    isoprenoid-derived lipids. Promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid
    dendritic cells (pDCs) by facilitating Lys-63'-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cells
    activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T helper
    2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins
    Induction: By interferon type I, type II and bacterial lipopolysaccharides (LPS). Little or no induction by
    IFNG/IFN-gamma is observed in monocytic cell lines. Induced by infection with hepatitis C virus, yellow fever
    virus and Sendai virus, presumably through type I interferon pathway. Induction by infection with human
    cytomegalovirus (HCMV), stomatitis virus (VSV), chikungunya virus (CHIKV), Japanese encephalitis virus (JEV)
    occurs independent of the IFN pathway

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity IEA--
    GO:0005515protein binding IPI--
    GO:0043621protein self-association IDA19074433
    GO:0046872metal ion binding IEA--
    GO:0051536iron-sulfur cluster binding ----
         
    Find genes that share ontologies with RSAD2           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rsad2):
     hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with RSAD2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for RSAD2: Rsad2tm1Kchc Rsad2tm1Aki

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RSAD2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RSAD2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RSAD2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RSAD2

    miRNA
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    miRTarBase miRNAs that target RSAD2:
    hsa-mir-146a-5p (MIRT021222), hsa-mir-26b-5p (MIRT028788)

    Block miRNA regulation of human, mouse, rat RSAD2 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate RSAD2:
    hsa-miR-183* hsa-miR-1267 hsa-miR-215 hsa-miR-3153 hsa-miR-192 hsa-miR-759 hsa-miR-664 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidRSAD2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RSAD2
    Predesigned siRNA for gene silencing in human, mouse, rat RSAD2

    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSAD2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSAD2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RSAD2_HUMAN, Q8WXG1: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi
    apparatus. Endoplasmic reticulum. Lipid droplet (By similarity). Mitochondrion. Mitochondrion inner membrane.
    Mitochondrion outer membrane. Note=Infection with human cytomegalovirus (HCMV) causes relocation to the Golgi
    apparatus and to cytoplasmic vacuoles which also contain HCMV proteins glycoprotein B and pp28. Interaction with
    human cytomegalovirus/HHV-5 protein vMIA/UL37 results in its relocalization from the endoplasmic reticulum to the
    mitochondria
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus5
    mitochondrion5
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005741mitochondrial outer membrane IDA--
    GO:0005743mitochondrial inner membrane IDA--
    GO:0005783endoplasmic reticulum IDA11752458
    GO:0005789endoplasmic reticulum membrane IDA19074433

    Find genes that share ontologies with RSAD2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RSAD2 About    
    See pathways by source

    SuperPathContained pathways About
    1Influenza A
    Influenza A0.34


    Find genes that share SuperPaths with RSAD2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for RSAD2):
        Influenza A

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RSAD2
    Interactions:

        Search GeneGlobe Interaction Network for RSAD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for RSAD2 (Q8WXG13 ENSP000003714714) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IRAK1P516173, ENSP000003589974I2D: score=1 STRING: ENSP00000358997
    IRF7Q929853, ENSP000003294114I2D: score=1 STRING: ENSP00000329411
    TRAF6Q9Y4K33I2D: score=1 
    FDPSENSP000003490784STRING: ENSP00000349078
    IFNB1ENSP000003695814STRING: ENSP00000369581
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0009615response to virus IDA--
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0030278regulation of ossification IEA--

    Find genes that share ontologies with RSAD2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RSAD2

    2 HMDB Compounds for RSAD2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    1 Novoseek inferred chemical compound relationship for RSAD2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    poly(i-c) 68.6 3 16849320 (2), 16108059 (1)



    Find genes that share compounds with RSAD2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RSAD2 gene: 
    NM_080657.4  

    Unigene Cluster for RSAD2:

    Radical S-adenosyl methionine domain containing 2
    Hs.17518  [show with all ESTs]
    Unigene Representative Sequence: NM_080657
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000474872 ENST00000442639 ENST00000382040(uc002qyp.1) ENST00000489749
    ENST00000477834 ENST00000541728
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate RSAD2:
    hsa-miR-183* hsa-miR-1267 hsa-miR-215 hsa-miR-3153 hsa-miR-192 hsa-miR-759 hsa-miR-664 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidRSAD2 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat RSAD2

    Additional mRNA sequence: 

    AF026942.1 AF442151.1 AK300085.1 AK312670.1 BC017969.1 

    7 DOTS entries:

    DT.91656825  DT.95245871  DT.100749837  DT.120968146  DT.120968159  DT.91656828  DT.95264578 

    Selected AceView cDNA sequences (see all 66):

    BM671901 CR601894 AW192721 BQ878044 BC017969 BQ689149 CR598269 AI337069 
    H68147 AF026942 BI824227 BX448162 CF137246 AL597246 BG058713 CA306417 
    CA308851 AI803838 AA036860 AV733313 BU663133 BU626979 AI446168 BQ109462 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RSAD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCGTACA
    RSAD2 Expression
    About this image


    RSAD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             Granulocytes Peripheral Blood
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Fibroblasts
             Dermal Fibroblasts Dorsal Dermis
    RSAD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RSAD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.17518
        Custom PCR Arrays for RSAD2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSAD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RSAD2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rsad21 , 5 radical S-adenosyl methionine domain containing 21, 5 80.82(n)1
    84.92(a)1
      12 (9.69 cM)5
    581851  NM_021384.41  NP_067359.21 
     264427535 
    chicken
    (Gallus gallus)
    Aves RSAD21 radical S-adenosyl methionine domain containing 2 76(n)
    81.63(a)
      428650  XM_426208.3  XP_426208.2 
    lizard
    (Anolis carolinensis)
    Reptilia RSAD26
    radical S-adenosyl methionine domain containing 2
    73(a)
    1 ↔ 1
    1(150120144-150136379)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rsad21 radical S-adenosyl methionine domain containing 2 66.67(n)
    70.55(a)
      100493449  XM_002935027.2  XP_002935073.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.58302 Transcribed sequences 76.81(n)    57058845 


    ENSEMBL Gene Tree for RSAD2 (if available)
    TreeFam Gene Tree for RSAD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RSAD2 (see all 506)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs13753341,2
    C,F,A,H--7015823(+) GGCCAC/TGGAAA 1 -- us2k1 tfbs317Minor allele frequency- T:0.00NS EA NA WA CSA 793
    rs7681581,2
    H--7015894(-) TTATAG/TCTGTT 1 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs1902402011,2
    --7015907(+) CAACAC/TTCATG 1 -- us2k10--------
    rs13753351,2
    C,F,O,A,H--7015964(+) ATATAT/ATTCAT 1 -- us2k119Minor allele frequency- A:0.08NA NS EA WA CSA 701
    rs1824645571,2
    --7016097(+) CTGCTC/TTACCA 1 -- us2k10--------
    rs1506951391,2
    --7016181(+) AGACTA/GTCTCC 1 -- us2k10--------
    rs790387211,2
    C,F--7016234(+) ACAGGG/ATAAAT 1 -- us2k11Minor allele frequency- A:0.09WA 118
    rs1856577151,2
    --7016364(+) TTTCCA/GGCCGG 1 -- us2k10--------
    rs1160117131,2
    F--7016378(+) CCCCTG/CCAGTA 1 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1401635101,2
    --7016590(+) ATTCAA/CATTTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RSAD2 (7005937 - 7038370 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RSAD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2596CNV Insertion18451855
    nsv833326CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RSAD2
    DNA2.0 Custom Variant and Variant Library Synthesis for RSAD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607810    OMIM disorders: --


    Find genes that share disorders with RSAD2           About GenesLikeMe

    Genetic Association Database (GAD): RSAD2
    Human Genome Epidemiology (HuGE) Navigator: RSAD2 (1 document)

    Export disorders for RSAD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RSAD2 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with RSAD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus. (PubMed id 11752458)1, 2, 3, 9 Chin K.-C. and Cresswell P. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    2. The N-terminal amphipathic alpha-helix of viperin mediates localization to the cytosolic face of the endoplasmic reticulum and inhibits protein secretion. (PubMed id 19074433)1, 2, 9 Hinson E.R. and Cresswell P. (J. Biol. Chem. 2009)
    3. Structural characterization reveals that viperin is a radical S- adenosyl-L-methionine (SAM) enzyme. (PubMed id 20026307)1, 2, 9 Shaveta G.... Song J. (Biochem. Biophys. Res. Commun. 2010)
    4. Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector. (PubMed id 16108059)1, 2, 9 Helbig K.J.... Beard M.R. (Hepatology 2005)
    5. Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1. (PubMed id 16849320)1, 2, 9 Severa M.... Fitzgerald K.A. (J. Biol. Chem. 2006)
    6. The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents. (PubMed id 15890971)1, 2, 9 Olofsson P.S.... Sirsjoe A. (Arterioscler. Thromb. Vasc. Biol. 2005)
    7. TLR3 ligation activates an antiviral response in human fetal astrocytes: a role for viperin/cig5. (PubMed id 16982913)1, 2, 9 Rivieccio M.A....Brosnan C.F. (J. Immunol. 2006)
    8. The antiviral protein viperin is a radical SAM enzyme. (PubMed id 20176015)1, 2, 9 Duschene K.S. and Broderick J.B. (FEBS Lett. 2010)
    9. The presence of the iron-sulfur motif is important for the conformational stability of the antiviral protein, Viperin. (PubMed id 22363738)1, 2 Haldar S.... Chattopadhyay K. (PLoS ONE 2012)
    10. Viperin, a key player in the antiviral response. (PubMed id 22182524)1, 2 Mattijssen S. and Pruijn G.J. (Microbes Infect. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 91543 HGNC: 30908 AceView: cig5 Ensembl:ENSG00000134321 euGenes: HUgn91543
    ECgene: RSAD2 Kegg: 91543 H-InvDB: RSAD2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RSAD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RSAD2 gene:
    Search GeneIP for patents involving RSAD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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