Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RSAD2 Gene

protein-coding   GIFtS: 52
GCID: GC02P007005

radical S-adenosyl methionine domain containing 2
 Explore 13 diseases affiliated with
RSAD2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RSAD2    

Aliases
for RSAD2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Radical S-Adenosyl Methionine Domain Containing 21 2     2510004L01Rik2
Cig51     Cig331
Vig11     Radical S-Adenosyl Methionine Domain-Containing Protein 22
Viperin3     CIG53
Cytomegalovirus-Induced Gene 5 Protein2 3     Viperin3
Virus Inhibitory Protein, Endoplasmic Reticulum-Associated,
Interferon-Inducible2 3
     VIPERIN5

External Ids:    HGNC: 309081   Entrez Gene: 915432   Ensembl: ENSG000001343217   OMIM: 6078105   UniProtKB: Q8WXG13   

Export aliases for RSAD2 gene to outside databases

Previous GC identifers: GC02P006969 GC02P006865


Summaries
for RSAD2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: RSAD2_HUMAN, Q8WXG1
Function: Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the
cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA viruses,
including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus,
influenza A virus, sendai virus, vesicular stomatitis virus (VSV), and human immunodeficiency virus (HIV-1). Displays
antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by
disturbing the lipid rafts. This is accomplished, at least in part, through binding and inhibition of the enzyme
farnesyl diphospate synthase (FPPS), which is essential for the biosynthesis of isoprenoid-derived lipids. Promotes
TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating
Lys-63'-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cells activation and differentiation. Facilitates
T-cell receptor (TCR)-mediated GATA3 activation and optimal T helper 2 (Th2) cytokine production by modulating NFKB1
and JUNB activities. Can inhibit secretion of soluble proteins




Genomic Views
for RSAD2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005334.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RSAD2 gene promoter:
         NF-1   NF-1/L   STAT5A   NF-kappaB   GATA-1   c-Ets-1   AREB6   HEN1   Sox9   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RSAD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RSAD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RSAD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.2   Ensembl cytogenetic band:  2p25.2   HGNC cytogenetic band: 2p25.2

RSAD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RSAD2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P007005:  view genomic region     (about GC identifiers)

Start:
 7,005,937 bp from pter      End:
 7,038,370 bp from pter
Size:
 32,434 bases      Orientation:
 plus strand

Proteins
for RSAD2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RSAD2_HUMAN, Q8WXG1 (See protein sequence)
Recommended Name: Radical S-adenosyl methionine domain-containing protein 2  
Size: 361 amino acids; 42170 Da
Cofactor: Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable
S-adenosyl-L-methionine
Subunit: Homodimer. Interacts with IRAK1 and TRAF6 (By similarity). Interacts with FPPS. Interacts with human
cytomegalovirus/HHV-5 protein vMIA/UL37; this interaction results in RSAD2/viperin relocalization from the endoplasmic
reticulum to the mitochondria. Interacts with HADHB. Interacts (via C-terminus) with VAPA/VAP33 (via C-terminus) and
inhibits its interaction with hepatitis virus C (HCV) protein NS5A
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus.
Endoplasmic reticulum. Lipid droplet (By similarity). Mitochondrion. Mitochondrion inner membrane. Mitochondrion outer
membrane. Note=Infection with human cytomegalovirus (HCMV) causes relocation to the Golgi apparatus and to cytoplasmic
vacuoles which also contain HCMV proteins glycoprotein B and pp28. Interaction with human cytomegalovirus/HHV-5
protein vMIA/UL37 results in its relocalization from the endoplasmic reticulum to the mitochondria
Miscellaneous: Up-regulated in atherosclerosis. Latent viruses like HCMV may be involved in atherogenesis by initiating
local inflammation. This may induce up-regulation of antiviral gene RSAD2, which modulates lipids synthesis, and thus
could play a role in abnormal lipid accumulation leading to atherosclerosis
Secondary accessions: Q8WVI4

Explore the universe of human proteins at neXtProt for RSAD2: NX_Q8WXG1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WXG1

    • RSAD2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_542388.2  
    ENSEMBL proteins: 
     ENSP00000406427   ENSP00000371471   ENSP00000440859  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: RSAD2
    OriGene Protein Over-expression Lysate: RSAD2
    OriGene Custom Protein Services for RSAD2 
    GenScript Custom Purified and Recombinant Proteins Services for RSAD2
    Novus Biologicals RSAD2 Proteins
    Novus Biologicals RSAD2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RSAD2

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005741mitochondrial outer membrane IDA--
    GO:0005743mitochondrial inner membrane IDA--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane IDA19074433


    RSAD2 for ontologies           About GeneDecksing



    RSAD2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RSAD2
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RSAD2 
    GenScript Custom Superior Antibodies Services for RSAD2
    Novus Biologicals RSAD2 Antibodies
    Search for Antibodies for RSAD2 at Abcam  
    Uscn Antibodies for RSAD2
    ThermoFisher Antibodies for RSAD2

    Assay Products for RSAD2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RSAD2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RSAD2

    Protein Domains /
    Families
    for RSAD2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RSAD2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR013785 Aldolase_TIM
     IPR007197 rSAM
     IPR026372 Viperin
     IPR006638 Elp3/MiaB/NifB

    Graphical View of Domain Structure for InterPro Entry Q8WXG1

    ProtoNet protein and cluster: Q8WXG1

    1 Blocks protein family: IPB006638 Elongator protein 3/MiaB/NifB

    UniProtKB/Swiss-Prot: RSAD2_HUMAN, Q8WXG1
    Domain: The N-terminal region (1-42) is necessary for its localization to the endoplasmic reticulum membrane and lipid
    droplet
    Similarity: Belongs to the radical SAM superfamily. RSAD2 family


    Function
    for RSAD2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RSAD2_HUMAN, Q8WXG1
    Function: Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the
    cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA viruses,
    including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus,
    influenza A virus, sendai virus, vesicular stomatitis virus (VSV), and human immunodeficiency virus (HIV-1). Displays
    antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by
    disturbing the lipid rafts. This is accomplished, at least in part, through binding and inhibition of the enzyme
    farnesyl diphospate synthase (FPPS), which is essential for the biosynthesis of isoprenoid-derived lipids. Promotes
    TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating
    Lys-63'-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cells activation and differentiation. Facilitates
    T-cell receptor (TCR)-mediated GATA3 activation and optimal T helper 2 (Th2) cytokine production by modulating NFKB1
    and JUNB activities. Can inhibit secretion of soluble proteins
    Induction: By interferon type I, type II and bacterial lipopolysaccharides (LPS). Little or no induction by
    IFNG/IFN-gamma is observed in monocytic cell lines. Induced by infection with hepatitis C virus, yellow fever virus
    and Sendai virus, presumably through type I interferon pathway. Induction by infection with human cytomegalovirus
    (HCMV), stomatitis virus (VSV), chikungunya virus (CHIKV), Japanese encephalitis virus (JEV) occurs independent of the
    IFN pathway

    miRNA
    Products:            		 OriGene 3'-UTR Clone: RSAD2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RSAD2
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate RSAD2:
    hsa-miR-183* hsa-miR-1267 hsa-miR-215 hsa-miR-3153 hsa-miR-192 hsa-miR-759 hsa-miR-664 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmid: RSAD2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RSAD2 (see all 7)
    OriGene siRNA: RSAD2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RSAD2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RSAD2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RSAD2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RSAD2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RSAD2 (NM_080657)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RSAD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSAD2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for RSAD2
    Search LifeMap BioReagents cell lines for RSAD2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSAD2

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003824catalytic activity IEA--
    GO:0005515protein binding IPI--
    GO:0043621protein self-association IDA19074433
    GO:0046872metal ion binding IEA--


    RSAD2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for RSAD2: Rsad2tm1Kchc Rsad2tm1Aki
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Rsad2):
     cellular  hematopoietic system  homeostasis/metabolism  immune system 

    RSAD2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RSAD2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Measles
    		Influenza A0.35

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for RSAD2):
        Influenza A


    RSAD2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RSAD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for RSAD2 (Q8WXG13 ENSP000003714714) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IRAK1P516173, ENSP000003589974I2D: score=1 STRING: ENSP00000358997
    IRF7Q929853, ENSP000003294114I2D: score=1 STRING: ENSP00000329411
    TRAF6Q9Y4K33I2D: score=1 
    FDPSENSP000003490784STRING: ENSP00000349078
    IFNB1ENSP000003695814STRING: ENSP00000369581
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0009615response to virus IDA--
    GO:0019048virus-host interaction IEA--
    GO:0030278regulation of ossification IEA--
    GO:0034157positive regulation of toll-like receptor 7 signaling pathway ISS--


    RSAD2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RSAD2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RSAD2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RSAD2

    2 HMDB Compounds for RSAD2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--
    1 Novoseek chemical compound relationship for RSAD2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    poly(i-c) 68.6 3 16849320 (2), 16108059 (1)

    Search CenterWatch for drugs/clinical trials and news about RSAD2 

    Transcripts
    for RSAD2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RSAD2 gene: 
    NM_080657.4  

    Unigene Cluster for RSAD2:

    Radical S-adenosyl methionine domain containing 2
    Hs.17518  [show with all ESTs]
    Unigene Representative Sequence: NM_080657
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000474872 ENST00000442639 ENST00000382040(uc002qyp.1) ENST00000489749
    ENST00000477834 ENST00000541728

    miRNA
    Products:             		 OriGene 3'-UTR Clone: RSAD2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RSAD2
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate RSAD2:
    hsa-miR-183* hsa-miR-1267 hsa-miR-215 hsa-miR-3153 hsa-miR-192 hsa-miR-759 hsa-miR-664 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmid: RSAD2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RSAD2 (see all 7)
    OriGene siRNA: RSAD2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RSAD2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RSAD2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RSAD2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RSAD2 (NM_080657)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RSAD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSAD2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RSAD2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RSAD2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RSAD2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RSAD2

    Additional cDNA sequence: 

    AF026942.1 AF442151.1 AK300085.1 AK312670.1 BC017969.1 

    7 DOTS entries:

    DT.91656825  DT.95245871  DT.100749837  DT.120968146  DT.120968159  DT.91656828  DT.95264578 

    24/66 AceView cDNA sequences (see all 66):

    BM671901 BQ878044 H68147 CR598269 BQ689149 BC017969 AI337069 CR601894 
    AW192721 AW003262 AA036860 BG058713 BI824227 AF442151 CA308851 BX448162 
    CD366806 AI446168 C01138 CA306417 AL597246 BU626979 BG500099 AF026942 

    GeneLoc Exon Structure


    Expression
    for RSAD2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RSAD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGGCGTACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RSAD2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierAdult Endothelial CellsBlood Brain Barrier, Endothelium
    HeartMyocardiumCardiac FibroblastsEpicardium
    PlacentaChorioallantoic PlacentaExtraembryonic AngioblastsEndothelium
    TestisSeminiferous TubulesSertoli cellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RSAD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RSAD2

    SOURCE GeneReport for Unigene cluster: Hs.17518
        SABiosciences Custom PCR Arrays for RSAD2
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RSAD2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RSAD2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RSAD2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RSAD2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSAD2

    Orthologs
    for RSAD2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for RSAD2 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rsad21 , 5 radical S-adenosyl methionine domain containing 21, 5 80.82(n)1
    84.92(a)1    		   12 (9.69 cM)5
    581851  NM_021384.41  NP_067359.21 
     264427535 
    chicken
    (Gallus gallus)    		 Aves RSAD21 radical S-adenosyl methionine domain containing 2 75.8(n)
    81.63(a)    		   428650  XM_426208.2  XP_426208.2 
    lizard
    (Anolis carolinensis)    		 Reptilia RSAD26
    		 --
    		 72(a)
    		 1 ↔ 1
    		 1(150122839-150135972)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.58302 Transcribed sequences 76.81(n)    57058845 


    ENSEMBL Gene Tree for RSAD2 (if available)
    TreeFam Gene Tree for RSAD2 (if available) 

    Paralogs
    for RSAD2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for RSAD2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/401 NCBI SNPs in RSAD2 are shown (see all 401)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs13753341,2
    		C,F,A,H,--7015823(+) GGCCAC/TGGAAA 1 -- us2k1 tfbs317Minor allele frequency- T:0.00NS EA NA WA CSA 793
    rs7681581,2
    		H--7015894(-) TTATAG/TCTGTT 1 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs1902402011,2
    		--7015907(+) CAACAC/TTCATG 1 -- us2k10--------
    rs13753351,2
    		C,F,O,A,H,--7015964(+) ATATAT/ATTCAT 1 -- us2k119Minor allele frequency- A:0.08NA NS EA WA CSA 701
    rs1824645571,2
    		--7016097(+) CTGCTC/TTACCA 1 -- us2k10--------
    rs1506951391,2
    		--7016181(+) AGACTA/GTCTCC 1 -- us2k10--------
    rs790387211,2
    		F,--7016234(+) ACAGGG/ATAAAT 1 -- us2k11Minor allele frequency- A:0.09WA 118
    rs1856577151,2
    		--7016364(+) TTTCCA/GGCCGG 1 -- us2k10--------
    rs1160117131,2
    		F,--7016378(+) CCCCTG/CCAGTA 1 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1401635101,2
    		--7016590(+) ATTCAA/CATTTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RSAD2 (7005937 - 7038370 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RSAD2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RSAD2
    DNA2.0 Custom Variant and Variant Library Synthesis for RSAD2

    Disorders / Diseases
    for RSAD2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RSAD2 for disorders           About GeneDecksing

    OMIM gene information: 607810    OMIM disorders: --

    13 diseases for RSAD2:    About MalaCards
    west nile virus    japanese encephalitis    yellow fever    cytomegalovirus infection
    encephalitis    hepatitis c    stomatitis    ovarian cancer
    influenza    atherosclerosis    hepatitis    cholesterol
    hypoxia

    Human Genome Epidemiology (HuGE) Navigator: RSAD2 (1 document)

    Export disorders for RSAD2 gene to outside databases

    Publications
    for RSAD2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RSAD2 gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with RSAD2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus. (PubMed id 11752458)1, 2, 3, 9 Chin K.-C. and Cresswell P. (2001)
    2. The N-terminal amphipathic alpha-helix of viperin mediates localization to the cytosolic face of the endoplasmic reticulum and inhibits protein secretion. (PubMed id 19074433)1, 2, 9 Hinson E.R. and Cresswell P. (2009)
    3. Structural characterization reveals that viperin is a radical S-adenosyl-L-methionine (SAM) enzyme. (PubMed id 20026307)1, 2, 9 Shaveta G....Song J. (2010)
    4. Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector. (PubMed id 16108059)1, 2, 9 Helbig K.J.... Beard M.R. (2005)
    5. Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1. (PubMed id 16849320)1, 2, 9 Severa M.... Fitzgerald K.A. (2006)
    6. The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents. (PubMed id 15890971)1, 2, 9 Olofsson P.S.... Sirsjoe A. (2005)
    7. TLR3 ligation activates an antiviral response in human fetal astrocytes: a role for viperin/cig5. (PubMed id 16982913)1, 2, 9 Rivieccio M.A....Brosnan C.F. (2006)
    8. The antiviral protein viperin is a radical SAM enzyme . (PubMed id 20176015)1, 2, 9 Duschene K.S. and Broderick J.B. (2010)
    9. The presence of the iron-sulfur motif is important for the conformational stability of the antiviral protein, Viperin. (PubMed id 22363738)1, 2 Haldar S....Chattopadhyay K. (2012)
    10. Viperin, a key player in the antiviral response. (PubMed id 22182524)1, 2 Mattijssen S. and Pruijn G.J. (2012)

    External Searches for RSAD2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RSAD2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 91543 HGNC: 30908 AceView: cig5 Ensembl:ENSG00000134321 euGenes: HUgn91543
    ECgene: RSAD2 Kegg: 91543 H-InvDB: RSAD2

    Other Databases showing RSAD2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RSAD2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RSAD2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RSAD2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RSAD2 gene:
    Search GeneIP for patents involving RSAD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for RSAD2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of RSAD2
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   Browse OriGene shRNA RFPs  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RSAD2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RSAD2  
     OriGene Protein Over-expression Lysate for RSAD2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for RSAD2   OriGene 3'-UTR Clone for RSAD2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RSAD2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RSAD2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for RSAD2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RSAD2   OriGene Custom Protein Services for RSAD2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RSAD2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RSAD2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RSAD2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RSAD2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RSAD2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RSAD2
     GenScript Custom Purified and Recombinant Proteins Services for RSAD2 GenScript cDNA clones with any tag delivered in your preferred vector for RSAD2
     GenScript Custom Assay Services for RSAD2 GenScript Custom Superior Antibodies Services for RSAD2
     GenScript Custom overexpressing Cell Line Services for RSAD2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RSAD2 promoter
     Search Chromatin IP Primers for RSAD2
     RT2 qPCR Primer Assay in human, mouse, rat RSAD2
     Search GNC Networks for RSAD2
     SABiosciences Custom PCR Arrays for RSAD2
     Search Tocris compounds for RSAD2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RSAD2 antibodies
     RSAD2 proteins
     RSAD2 lysates
     Search for Antibodies for RSAD2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for RSAD2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     RSAD2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for RSAD2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSAD2
     SwitchGear 3'UTR luciferase reporter plasmids for RSAD2
     SwitchGear Promoter luciferase reporter plasmids for RSAD2
     ThermoFisher Antibodies for RSAD2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSAD2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      RSAD2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4