RSAD1 Gene
protein-coding GIFtS: 46
GCID: GC17P048556
|
|
radical S-adenosyl methionine domain containing 1
| |
Aliases
for RSAD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Radical S-Adenosyl Methionine Domain Containing 11 2 | | EC 1.3.99.-3 | | Oxygen-Independent Coproporphyrinogen-III Oxidase-Like Protein RSAD12 3 | | EC 1.3.998 | | FLJ111641 | | EC 1.3.99.228 | | Radical S-Adenosyl Methionine Domain-Containing Protein 1, Mitochondrial2 | | |
Export aliases for RSAD1 gene to outside databasesPrevious GC identifers: GC17P045912 GC17P043924 |
Summaries
for RSAD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RSAD1_HUMAN, Q9HA92Function: May be involved in porphyrin cofactor biosynthesis (By similarity)
|
Genomic Views
for RSAD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RSAD1 gene promoter:
NF-1/L NF-1 p53 Brachyury Pax-2 Pax-2a HNF-4alpha2 HNF-4alpha1 MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RSAD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RSAD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.33 Ensembl cytogenetic band: 17q21.33 HGNC cytogenetic band: 17q21.33RSAD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P048556: view genomic region
(about GC identifiers)
Start:
|
48,556,161 bp from pter |
End:
|
48,563,336 bp from pter |
Size:
|
7,176 bases |
Orientation:
|
plus strand |
|
Proteins
for RSAD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RSAD1_HUMAN, Q9HA92 (See
protein sequence)Recommended Name: Radical S-adenosyl methionine domain-containing protein 1, mitochondrial precursor Size: 442 amino acids; 48714 Da
Cofactor: Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeableS-adenosyl-L-methionine (Potential)
Subcellular location: Mitochondrion (Potential)
Secondary accessions: Q53HV8 Q86VC4 Q9BRY7 Q9NUS7Explore the universe of human proteins at neXtProt for RSAD1: NX_Q9HA92
4 DME Specific Peptides for RSAD1 (Q9HA92)
RSAD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060816.1
ENSEMBL proteins: ENSP00000258955 ENSP00000424558 ENSP00000425372 ENSP00000465567 ENSP00000422893
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
RSAD1 for ontologies About GeneDecksing
RSAD1 Antibody Products:
Assay Products for RSAD1: |
Protein
Domains /
Families
for RSAD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RSAD1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9HA92ProtoNet protein and cluster: Q9HA92 1 Blocks protein family: IPB006638 Elongator protein 3/MiaB/NifB
UniProtKB/Swiss-Prot: RSAD1_HUMAN, Q9HA92Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family |
Function
for RSAD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RSAD1_HUMAN, Q9HA92Function: May be involved in porphyrin cofactor biosynthesis (By similarity)Enzyme Numbers (IUBMB): EC 1.3.992 EC 1.3.99.222 EC 1.3.99.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RSAD1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RSAD1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RSAD1 (NM_018346) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RSAD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSAD1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSAD1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004109 | coproporphyrinogen oxidase activity |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- | | GO:0051539 | 4 iron, 4 sulfur cluster binding |
IEA | -- |
RSAD1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RSAD1:
|
Pathways & Interactions
for RSAD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RSAD1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
4 Interacting proteins for RSAD1 (Q9HA923 ENSP000002589554) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006779 | porphyrin-containing compound biosynthetic process |
IEA | -- |
RSAD1 for ontologies About GeneDecksing
|
Drugs & Compounds
for RSAD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RSAD1
1 HMDB Compound for RSAD1 About this table
Search CenterWatch for drugs/clinical trials and news about RSAD1
|
Transcripts
for RSAD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RSAD1 gene: NM_018346.1 Unigene Cluster for RSAD1: Radical S-adenosyl methionine domain containing 1 Hs.8033 [show with all ESTs]Unigene Representative Sequence: AK0020268 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000258955(uc002iqw.1 uc010wmq.1) ENST00000443328(uc010wmp.2)
ENST00000515221 ENST00000504284 ENST00000510554 ENST00000506211 ENST00000509398
ENST00000513650
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RSAD1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RSAD1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RSAD1 (NM_018346) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RSAD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSAD1 |
Additional cDNA sequence: AK002026.1 AK022105.1 AK024628.1 AK222472.1 AK293814.1 AK297655.1 BC005854.2 BC050538.1 14 DOTS entries: DT.442467 DT.100792965 DT.100792967 DT.402970 DT.100792963 DT.120971878 DT.95273663 DT.120971901 DT.75160905 DT.95087348 DT.100659056 DT.100792962 DT.120971896 DT.86855383 24/233 AceView cDNA sequences (see all 233): BM713111 BF805231 BQ437032 AV653956 CA425932 BQ066444 BI822661 BQ064844 BM916831 AK024628 AK022105 BM701378 CB140338 BE671496 BQ065969 CR621437 BM561668 CK904061 NM_018346 BF805228 AK002026 AA437121 BQ012945 BQ059574
GeneLoc Exon Structure
|
Expression
for RSAD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RSAD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTCTATTTA
About this image
See RSAD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RSAD1
SOURCE GeneReport for Unigene cluster: Hs.8033
SABiosciences Custom PCR Arrays for RSAD1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RSAD1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RSAD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RSAD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RSAD1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSAD1 |
Orthologs
for RSAD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for RSAD1 gene from 7/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Rsad11 , 5 |
radical S-adenosyl methionine domain containing 11, 5 |
83.79(n)1
84.62(a)1 |
|
11 (58.90 cM)5
2379261 NM_001013381.21 NP_001013399.11
945397985 |
lizard
(Anolis carolinensis) |
Reptilia |
RSAD16 |
-- |
63(a) |
1 ↔ 1 |
2(116329561-116343695) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BJ630748.12 |
-- |
71.44(n) |
|
BJ630748.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
rsad11 |
radical S-adenosyl methionine domain containing 1 |
59.07(n)
60.51(a) |
|
565897 NM_001083557.1 NP_001077026.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G632906 |
oxygen-independent coproporphyrinogen III oxidase |
21(a) |
1 ↔ 1 |
5(25369245-25370921) |
rice
(Oryza sativa) |
Liliopsida |
-- |
radical SAM enzyme, putative, expressed |
24(a) |
1 ↔ 1 |
12(9764080-9769741) |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
yggW6 |
predicted oxidoreductase, HemN family |
29(a) |
1 ↔ 1 |
Chromosome(3095289-3096425) |
ENSEMBL Gene Tree for RSAD1 (if available)
TreeFam Gene Tree for RSAD1 (if available) |
Paralogs
for RSAD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RSAD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RSAD1 (48556161 - 48563336 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RSAD1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RSAD1 |
|
Disorders
/ Diseases
for RSAD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RSAD1 for disorders About GeneDecksing
3  diseases for RSAD1: About MalaCardspneumonia tuberculosis mycobacterium tuberculosis
Human Genome Epidemiology (HuGE) Navigator: RSAD1 (1 document)
Export disorders for RSAD1 gene to outside databases
|
Publications
for RSAD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RSAD1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RSAD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
|
External Searches for RSAD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RSAD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RSAD1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RSAD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RSAD1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RSAD1 gene:
Search GeneIP for patents involving RSAD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RSAD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RSAD1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RSAD1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RSAD1 | | | OriGene Protein Over-expression Lysate for RSAD1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RSAD1 | | OriGene 3'-UTR Clone for RSAD1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RSAD1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RSAD1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RSAD1 | | OriGene Custom Protein Services for RSAD1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RSAD1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RSAD1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RSAD1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RSAD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RSAD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RSAD1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for RSAD1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | RSAD1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RSAD1 |
|  |  |  | | | | ThermoFisher Antibody for RSAD1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RSAD1 |
|
|
|
|
