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Aliases for RSAD1 Gene

Aliases for RSAD1 Gene

  • Radical S-Adenosyl Methionine Domain Containing 1 2 3 5
  • Oxygen-Independent Coproporphyrinogen-III Oxidase-Like Protein RSAD1 4
  • EC 1.3.99.22 61
  • EC 1.3.99.- 4
  • EC 1.3.99 61

External Ids for RSAD1 Gene

Previous GeneCards Identifiers for RSAD1 Gene

  • GC17P045912
  • GC17P048556
  • GC17P043924

Summaries for RSAD1 Gene

GeneCards Summary for RSAD1 Gene

RSAD1 (Radical S-Adenosyl Methionine Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding and coproporphyrinogen oxidase activity.

UniProtKB/Swiss-Prot for RSAD1 Gene

  • May be involved in porphyrin cofactor biosynthesis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSAD1 Gene

Genomics for RSAD1 Gene

Regulatory Elements for RSAD1 Gene

Enhancers for RSAD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G050507 1.3 Ensembl ENCODE 21.8 +31.2 31228 5.0 HDGF PKNOX1 CREB3L1 SIN3A FEZF1 ZNF2 ZNF766 ZNF143 ZNF207 FOS MYCBPAP EPN3 RSAD1 ACSF2 LOC105371824 SPATA20 CACNA1G-AS1 CACNA1G CHAD ANKRD40
GH17G050423 1.1 ENCODE 25.4 -51.8 -51808 6.9 HDGF FOXA2 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 RSAD1 CHAD ENSG00000253102 LRRC59 CACNA1G-AS1 EPN3 MYCBPAP CACNA1G ACSF2 XYLT2
GH17G050467 1.6 Ensembl ENCODE dbSUPER 15.3 -9.9 -9879 2.9 HDGF PKNOX1 ARNT FEZF1 ZNF766 ZNF263 JUNB REST ZNF592 SMARCA4 ACSF2 RSAD1 CHAD SPATA20 EPN3 MRPS21P9
GH17G050477 1.4 ENCODE dbSUPER 15.2 +0.2 175 2.4 HNRNPUL1 PKNOX1 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 FEZF1 RSAD1 ACSF2 CHAD MYCBPAP PIR52344
GH17G050458 1.3 ENCODE dbSUPER 13.9 -19.8 -19787 1.9 FOXA2 MLX ZFP64 ARID4B ZNF48 YY1 GLIS2 FOS SP5 SMARCB1 ACSF2 RSAD1 CHAD SPATA20 MRPS21P9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RSAD1 on UCSC Golden Path with GeneCards custom track

Promoters for RSAD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000095672 300 1001 HNRNPUL1 PKNOX1 MLX ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 FEZF1

Genomic Location for RSAD1 Gene

Chromosome:
17
Start:
50,478,800 bp from pter
End:
50,502,164 bp from pter
Size:
23,365 bases
Orientation:
Plus strand

Genomic View for RSAD1 Gene

Genes around RSAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RSAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RSAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSAD1 Gene

Proteins for RSAD1 Gene

  • Protein details for RSAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HA92-RSAD1_HUMAN
    Recommended name:
    Radical S-adenosyl methionine domain-containing protein 1, mitochondrial
    Protein Accession:
    Q9HA92
    Secondary Accessions:
    • B4DMW0
    • Q53HV8
    • Q86VC4
    • Q9BRY7
    • Q9NUS7

    Protein attributes for RSAD1 Gene

    Size:
    442 amino acids
    Molecular mass:
    48714 Da
    Cofactor:
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RSAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RSAD1 Gene

Selected DME Specific Peptides for RSAD1 Gene

Q9HA92:
  • YCNFNKY
  • LYVHWPYC
  • RGLRCSWEGL
  • GGGTPSL

Post-translational modifications for RSAD1 Gene

  • Ubiquitination at isoforms=331
  • Modification sites at PhosphoSitePlus

Other Protein References for RSAD1 Gene

Domains & Families for RSAD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HA92

UniProtKB/Swiss-Prot:

RSAD1_HUMAN :
  • Belongs to the anaerobic coproporphyrinogen-III oxidase family.
Family:
  • Belongs to the anaerobic coproporphyrinogen-III oxidase family.
genes like me logo Genes that share domains with RSAD1: view

No data available for Gene Families for RSAD1 Gene

Function for RSAD1 Gene

Molecular function for RSAD1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in porphyrin cofactor biosynthesis.

Enzyme Numbers (IUBMB) for RSAD1 Gene

Gene Ontology (GO) - Molecular Function for RSAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004109 coproporphyrinogen oxidase activity IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0051536 iron-sulfur cluster binding IEA --
GO:0051539 4 iron, 4 sulfur cluster binding IEA --
genes like me logo Genes that share ontologies with RSAD1: view
genes like me logo Genes that share phenotypes with RSAD1: view

Animal Models for RSAD1 Gene

MGI Knock Outs for RSAD1:

Animal Model Products

CRISPR Products

miRNA for RSAD1 Gene

miRTarBase miRNAs that target RSAD1

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RSAD1 Gene

Localization for RSAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RSAD1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RSAD1 gene
Compartment Confidence
mitochondrion 4
nucleus 3
cytosol 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for RSAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with RSAD1: view

Pathways & Interactions for RSAD1 Gene

SuperPathways for RSAD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RSAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006779 porphyrin-containing compound biosynthetic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with RSAD1: view

No data available for Pathways by source and SIGNOR curated interactions for RSAD1 Gene

Drugs & Compounds for RSAD1 Gene

(1) Drugs for RSAD1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
genes like me logo Genes that share compounds with RSAD1: view

Transcripts for RSAD1 Gene

Unigene Clusters for RSAD1 Gene

Radical S-adenosyl methionine domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RSAD1 Gene

No ASD Table

Relevant External Links for RSAD1 Gene

GeneLoc Exon Structure for
RSAD1
ECgene alternative splicing isoforms for
RSAD1

Expression for RSAD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RSAD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RSAD1 Gene

This gene is overexpressed in Cervix (45.6) and Skin (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RSAD1 Gene



Protein tissue co-expression partners for RSAD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RSAD1 Gene:

RSAD1

SOURCE GeneReport for Unigene cluster for RSAD1 Gene:

Hs.8033

Evidence on tissue expression from TISSUES for RSAD1 Gene

  • Nervous system(4.7)
  • Intestine(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with RSAD1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RSAD1 Gene

Orthologs for RSAD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RSAD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RSAD1 34 35
  • 99.32 (n)
cow
(Bos Taurus)
Mammalia RSAD1 34 35
  • 86.95 (n)
dog
(Canis familiaris)
Mammalia RSAD1 34
  • 86.37 (n)
rat
(Rattus norvegicus)
Mammalia Rsad1 34
  • 84.25 (n)
mouse
(Mus musculus)
Mammalia Rsad1 35 16 34
  • 84.25 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RSAD1 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RSAD1 35
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RSAD1 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rsad1 34
  • 64.22 (n)
zebrafish
(Danio rerio)
Actinopterygii rsad1 34 35
  • 59.66 (n)
Species where no ortholog for RSAD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RSAD1 Gene

ENSEMBL:
Gene Tree for RSAD1 (if available)
TreeFam:
Gene Tree for RSAD1 (if available)

Paralogs for RSAD1 Gene

No data available for Paralogs for RSAD1 Gene

Variants for RSAD1 Gene

Sequence variations from dbSNP and Humsavar for RSAD1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000136382 -- 50,479,539(+) GGATA(-/GGGGTG)GGGGT intron-variant
rs1000176049 -- 50,481,556(+) ACCAT(C/T)GTAGA intron-variant
rs1000580099 -- 50,479,839(+) CCCAG(A/C)GGGCT intron-variant
rs1000696835 -- 50,481,310(+) ATTTC(C/T)TGAAC intron-variant
rs1001075304 -- 50,485,672(+) TGTGT(C/G)CAGCA nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RSAD1 Gene

Variant ID Type Subtype PubMed ID
nsv2081 CNV deletion 18451855

Variation tolerance for RSAD1 Gene

Residual Variation Intolerance Score: 33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RSAD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RSAD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSAD1 Gene

Disorders for RSAD1 Gene

Relevant External Links for RSAD1

Genetic Association Database (GAD)
RSAD1
Human Genome Epidemiology (HuGE) Navigator
RSAD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RSAD1

No disorders were found for RSAD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RSAD1 Gene

Publications for RSAD1 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64

Products for RSAD1 Gene

Sources for RSAD1 Gene

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