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Aliases for RSAD1 Gene

Aliases for RSAD1 Gene

  • Radical S-Adenosyl Methionine Domain Containing 1 2 3
  • Oxygen-Independent Coproporphyrinogen-III Oxidase-Like Protein RSAD1 4
  • EC 1.3.99.22 63
  • EC 1.3.99.- 4
  • EC 1.3.99 63

External Ids for RSAD1 Gene

Previous GeneCards Identifiers for RSAD1 Gene

  • GC17P045912
  • GC17P048556
  • GC17P043924

Summaries for RSAD1 Gene

GeneCards Summary for RSAD1 Gene

RSAD1 (Radical S-Adenosyl Methionine Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding and coproporphyrinogen oxidase activity.

UniProtKB/Swiss-Prot for RSAD1 Gene

  • May be involved in porphyrin cofactor biosynthesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RSAD1 Gene

Genomics for RSAD1 Gene

Regulatory Elements for RSAD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RSAD1 Gene

Chromosome:
17
Start:
50,478,800 bp from pter
End:
50,502,164 bp from pter
Size:
23,365 bases
Orientation:
Plus strand

Genomic View for RSAD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RSAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RSAD1 Gene

Proteins for RSAD1 Gene

  • Protein details for RSAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HA92-RSAD1_HUMAN
    Recommended name:
    Radical S-adenosyl methionine domain-containing protein 1, mitochondrial
    Protein Accession:
    Q9HA92
    Secondary Accessions:
    • B4DMW0
    • Q53HV8
    • Q86VC4
    • Q9BRY7
    • Q9NUS7

    Protein attributes for RSAD1 Gene

    Size:
    442 amino acids
    Molecular mass:
    48714 Da
    Cofactor:
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RSAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RSAD1 Gene

Proteomics data for RSAD1 Gene at MOPED

Selected DME Specific Peptides for RSAD1 Gene

Post-translational modifications for RSAD1 Gene

  • Ubiquitination at Lys 331
  • Modification sites at PhosphoSitePlus

Other Protein References for RSAD1 Gene

Antibody Products

Domains & Families for RSAD1 Gene

Protein Domains for RSAD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HA92

UniProtKB/Swiss-Prot:

RSAD1_HUMAN :
  • Belongs to the anaerobic coproporphyrinogen-III oxidase family.
Family:
  • Belongs to the anaerobic coproporphyrinogen-III oxidase family.
genes like me logo Genes that share domains with RSAD1: view

No data available for Gene Families for RSAD1 Gene

Function for RSAD1 Gene

Molecular function for RSAD1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in porphyrin cofactor biosynthesis.

Enzyme Numbers (IUBMB) for RSAD1 Gene

Gene Ontology (GO) - Molecular Function for RSAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004109 coproporphyrinogen oxidase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0051536 iron-sulfur cluster binding --
GO:0051539 4 iron, 4 sulfur cluster binding IEA --
genes like me logo Genes that share ontologies with RSAD1: view

Phenotypes for RSAD1 Gene

genes like me logo Genes that share phenotypes with RSAD1: view

Animal Model Products

miRNA for RSAD1 Gene

miRTarBase miRNAs that target RSAD1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RSAD1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for RSAD1 Gene

Localization for RSAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RSAD1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RSAD1 Gene COMPARTMENTS Subcellular localization image for RSAD1 gene
Compartment Confidence
mitochondrion 3
cytosol 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for RSAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with RSAD1: view

Pathways & Interactions for RSAD1 Gene

SuperPathways for RSAD1 Gene

No Data Available

Interacting Proteins for RSAD1 Gene

Selected Interacting proteins: Q9HA92-RSAD1_HUMAN for RSAD1 Gene via I2D

Symbol External ID(s) Details
CAMKK2
WIPI2

Gene Ontology (GO) - Biological Process for RSAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006779 porphyrin-containing compound biosynthetic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with RSAD1: view

No data available for Pathways by source and SIGNOR curated interactions for RSAD1 Gene

Drugs & Compounds for RSAD1 Gene

(1) Drugs for RSAD1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
genes like me logo Genes that share compounds with RSAD1: view

Transcripts for RSAD1 Gene

Unigene Clusters for RSAD1 Gene

Radical S-adenosyl methionine domain containing 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RSAD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RSAD1 Gene

No ASD Table

Relevant External Links for RSAD1 Gene

GeneLoc Exon Structure for
RSAD1
ECgene alternative splicing isoforms for
RSAD1

Expression for RSAD1 Gene

mRNA expression in normal human tissues for RSAD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RSAD1 Gene

This gene is overexpressed in Cervix (45.6) and Skin (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for RSAD1 Gene



SOURCE GeneReport for Unigene cluster for RSAD1 Gene Hs.8033

genes like me logo Genes that share expression patterns with RSAD1: view

Protein tissue co-expression partners for RSAD1 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RSAD1 Gene

Orthologs for RSAD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RSAD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RSAD1 35
  • 86.95 (n)
  • 86.43 (a)
RSAD1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RSAD1 35
  • 86.37 (n)
  • 86.53 (a)
mouse
(Mus musculus)
Mammalia Rsad1 35
  • 84.25 (n)
  • 85.92 (a)
Rsad1 16
Rsad1 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RSAD1 35
  • 99.32 (n)
  • 98.64 (a)
RSAD1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rsad1 35
  • 84.25 (n)
  • 85.2 (a)
oppossum
(Monodelphis domestica)
Mammalia RSAD1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RSAD1 36
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RSAD1 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rsad1 35
  • 64.22 (n)
  • 66.84 (a)
zebrafish
(Danio rerio)
Actinopterygii rsad1 35
  • 59.66 (n)
  • 61.44 (a)
rsad1 36
  • 54 (a)
OneToOne
Species with no ortholog for RSAD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RSAD1 Gene

ENSEMBL:
Gene Tree for RSAD1 (if available)
TreeFam:
Gene Tree for RSAD1 (if available)

Paralogs for RSAD1 Gene

No data available for Paralogs for RSAD1 Gene

Variants for RSAD1 Gene

Sequence variations from dbSNP and Humsavar for RSAD1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs557 -- 50,485,873(-) TTCCC(A/G)AATTC utr-variant-3-prime, nc-transcript-variant, intron-variant
rs9775 -- 50,485,928(-) TGTGA(C/T)CATTT utr-variant-3-prime, nc-transcript-variant, intron-variant
rs1043999 -- 50,485,785(+) CTCTT(C/T)TGAGC utr-variant-3-prime, nc-transcript-variant, intron-variant
rs1044025 -- 50,485,855(+) GACCA(A/G)AGAAA utr-variant-3-prime, nc-transcript-variant, intron-variant
rs1044035 -- 50,485,900(+) TAATT(C/T)TTCTT utr-variant-3-prime, nc-transcript-variant, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RSAD1 Gene

Variant ID Type Subtype PubMed ID
dgv3228n71 CNV Gain 21882294
nsv908600 CNV Gain 21882294
nsv2081 CNV Loss 18451855

Variation tolerance for RSAD1 Gene

Residual Variation Intolerance Score: 33.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RSAD1 Gene

HapMap Linkage Disequilibrium report
RSAD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RSAD1 Gene

Disorders for RSAD1 Gene

Relevant External Links for RSAD1

Genetic Association Database (GAD)
RSAD1
Human Genome Epidemiology (HuGE) Navigator
RSAD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RSAD1
genes like me logo Genes that share disorders with RSAD1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RSAD1 Gene

Publications for RSAD1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 67
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for RSAD1 Gene

Sources for RSAD1 Gene

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