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Aliases for RRS1 Gene

Aliases for RRS1 Gene

  • Ribosome Biogenesis Regulator Homolog 2 3 5
  • RRS1 Ribosome Biogenesis Regulator Homolog (S. Cerevisiae) 2
  • KIAA0112 4
  • RRR 4

External Ids for RRS1 Gene

Previous GeneCards Identifiers for RRS1 Gene

  • GC08P067280
  • GC08P067064
  • GC08P067391
  • GC08P067503
  • GC08P067341
  • GC08P062831

Summaries for RRS1 Gene

GeneCards Summary for RRS1 Gene

RRS1 (Ribosome Biogenesis Regulator Homolog) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for RRS1 Gene

  • Involved in ribosome biogenesis.

Gene Wiki entry for RRS1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRS1 Gene

Genomics for RRS1 Gene

Regulatory Elements for RRS1 Gene

Enhancers for RRS1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RRS1 on UCSC Golden Path with GeneCards custom track

Promoters for RRS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RRS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RRS1 Gene

66,429,028 bp from pter
66,430,733 bp from pter
1,706 bases
Plus strand

Genomic View for RRS1 Gene

Genes around RRS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRS1 Gene

Proteins for RRS1 Gene

  • Protein details for RRS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribosome biogenesis regulatory protein homolog
    Protein Accession:
    Secondary Accessions:
    • Q9BUX8

    Protein attributes for RRS1 Gene

    365 amino acids
    Molecular mass:
    41193 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA04948.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RRS1 Gene

Proteomics data for RRS1 Gene at MOPED

Post-translational modifications for RRS1 Gene

Other Protein References for RRS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RRS1 Gene

Domains & Families for RRS1 Gene

Protein Domains for RRS1 Gene

Suggested Antigen Peptide Sequences for RRS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RRS1 family.
  • Belongs to the RRS1 family.
genes like me logo Genes that share domains with RRS1: view

No data available for Gene Families for RRS1 Gene

Function for RRS1 Gene

Molecular function for RRS1 Gene

UniProtKB/Swiss-Prot Function:
Involved in ribosome biogenesis.
genes like me logo Genes that share phenotypes with RRS1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRS1 Gene

Localization for RRS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRS1 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for RRS1 Gene COMPARTMENTS Subcellular localization image for RRS1 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 3
cytosol 2
chloroplast 1
extracellular 1

Gene Ontology (GO) - Cellular Components for RRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA --
GO:0030687 preribosome, large subunit precursor IBA --
genes like me logo Genes that share ontologies with RRS1: view

Pathways & Interactions for RRS1 Gene

SuperPathways for RRS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0042273 ribosomal large subunit biogenesis IBA --
genes like me logo Genes that share ontologies with RRS1: view

No data available for Pathways by source and SIGNOR curated interactions for RRS1 Gene

Drugs & Compounds for RRS1 Gene

No Compound Related Data Available

Transcripts for RRS1 Gene

mRNA/cDNA for RRS1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(133) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RRS1 Gene

RRS1 ribosome biogenesis regulator homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RRS1 Gene

No ASD Table

Relevant External Links for RRS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RRS1 Gene

mRNA expression in normal human tissues for RRS1 Gene

Protein differential expression in normal tissues from HIPED for RRS1 Gene

This gene is overexpressed in Liver (18.2), Lung (16.5), Peripheral blood mononuclear cells (10.4), and Breast (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RRS1 Gene

SOURCE GeneReport for Unigene cluster for RRS1 Gene Hs.71827

genes like me logo Genes that share expression patterns with RRS1: view

Protein tissue co-expression partners for RRS1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RRS1 Gene

Orthologs for RRS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RRS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RRS1 35
  • 89.77 (n)
  • 93.7 (a)
RRS1 36
  • 94 (a)
(Canis familiaris)
Mammalia RRS1 35
  • 90.41 (n)
  • 94.25 (a)
RRS1 36
  • 94 (a)
(Mus musculus)
Mammalia Rrs1 35
  • 87.95 (n)
  • 90.68 (a)
Rrs1 16
Rrs1 36
  • 91 (a)
(Pan troglodytes)
Mammalia RRS1 35
  • 94.41 (n)
  • 91.47 (a)
RRS1 36
  • 93 (a)
(Rattus norvegicus)
Mammalia Rrs1 35
  • 87.12 (n)
  • 91.51 (a)
(Monodelphis domestica)
Mammalia RRS1 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia RRS1 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.641 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15190 35
(Danio rerio)
Actinopterygii rrs1 35
  • 63.59 (n)
  • 65.61 (a)
wufj66c04 35
rrs1 36
  • 62 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2989 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006808 35
  • 51.84 (n)
  • 43.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32409 35
  • 54.05 (n)
  • 46.6 (a)
CG32409 36
  • 44 (a)
(Caenorhabditis elegans)
Secernentea C15H11.9 37
  • 45 (a)
rrbs-1 35
  • 50.86 (n)
  • 47.81 (a)
rrbs-1 36
  • 41 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL014C 35
  • 55.56 (n)
  • 46.2 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13046g 35
  • 50.99 (n)
  • 43.45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRS1 35
  • 48.34 (n)
  • 43.86 (a)
RRS1 36
  • 37 (a)
RRS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G37990 35
  • 46.91 (n)
  • 40.73 (a)
(Oryza sativa)
Liliopsida Os04g0685100 35
  • 48.96 (n)
  • 41.39 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08121 35
  • 51.88 (n)
  • 45.97 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rrs1 35
  • 47.01 (n)
  • 45.52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.984 36
  • 47 (a)
Species with no ortholog for RRS1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRS1 Gene

Gene Tree for RRS1 (if available)
Gene Tree for RRS1 (if available)

Paralogs for RRS1 Gene

No data available for Paralogs for RRS1 Gene

Variants for RRS1 Gene

Sequence variations from dbSNP and Humsavar for RRS1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_020484 -
VAR_051887 -
VAR_051888 -

Variation tolerance for RRS1 Gene

Residual Variation Intolerance Score: 81.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.02; 74.99% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for RRS1 Gene

Disorders for RRS1 Gene

Relevant External Links for RRS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RRS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRS1 Gene

Publications for RRS1 Gene

  1. A nucleolar protein RRS1 contributes to chromosome congression. (PMID: 19465021) Gambe A.E. … Fukui K. (FEBS Lett. 2009) 2 3 67
  2. RRS1, a conserved essential gene, encodes a novel regulatory protein required for ribosome biogenesis in Saccharomyces cerevisiae. (PMID: 10688653) Tsuno A. … Mizuta K. (Mol. Cell. Biol. 2000) 2 3
  3. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for RRS1 Gene

Sources for RRS1 Gene