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Aliases for RRS1 Gene

Aliases for RRS1 Gene

  • Ribosome Biogenesis Regulator Homolog 2 3 5
  • RRS1 Ribosome Biogenesis Regulator Homolog (S. Cerevisiae) 2
  • KIAA0112 4
  • RRR 4

External Ids for RRS1 Gene

Previous GeneCards Identifiers for RRS1 Gene

  • GC08P067280
  • GC08P067064
  • GC08P067391
  • GC08P067503
  • GC08P067341
  • GC08P062831

Summaries for RRS1 Gene

GeneCards Summary for RRS1 Gene

RRS1 (Ribosome Biogenesis Regulator Homolog) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for RRS1 Gene

  • Involved in ribosome biogenesis.

Gene Wiki entry for RRS1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRS1 Gene

Genomics for RRS1 Gene

Regulatory Elements for RRS1 Gene

Enhancers for RRS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F066605 1.7 FANTOM5 Ensembl ENCODE 10.4 +181.3 181349 8.9 PKNOX1 CREB3L1 ARID4B SIN3A YY1 SLC30A9 ZNF143 SP3 SP5 NFYC ADHFE1 RRS1 RRS1-AS1 MYBL1 C8orf44 C8orf46 VCPIP1 GC08M066613 RNU6-1324P
GH08F066141 1.6 FANTOM5 Ensembl ENCODE 10.3 -286.6 -286638 2.4 HDAC1 ATF1 CBX3 TBL1XR1 ARNT RAD21 CHAMP1 GATA2 ETV6 CREM TRY-GTA5-1 CRH ADHFE1 RRS1 RRS1-AS1 LINC00967 GC08P066131 GC08P066135 GC08P066170 PIR59286
GH08F066021 1.6 FANTOM5 Ensembl ENCODE 10.1 -406.7 -406746 2.3 PKNOX1 RAD21 GLIS2 ZNF366 SCRT2 FOS ZNF263 SMARCC1 SP5 CEBPB PDE7A MTFR1 ADHFE1 RRS1 RRS1-AS1 LOC105375883 GC08M066012
GH08F066451 1.3 Ensembl ENCODE 10.6 +24.0 23978 2.4 ATF1 ARNT ZNF766 KLF13 JUNB NCOA1 CREB3 MEF2D MBD2 SMARCA4 C8orf46 ADHFE1 RRS1 RRS1-AS1 C8orf44 LOC102724687
GH08F066026 1.2 Ensembl ENCODE 10.7 -400.6 -400560 4.4 PKNOX1 SIN3A FEZF1 ZNF207 FOS DEK SMARCB1 MBD2 GLIS1 STAT3 PDE7A MTFR1 ADHFE1 RRS1 RRS1-AS1 ENSG00000272010 LOC105375883 GC08M066089
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RRS1 on UCSC Golden Path with GeneCards custom track

Promoters for RRS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001393449 1472 5001 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for RRS1 Gene

66,429,028 bp from pter
66,430,733 bp from pter
1,706 bases
Plus strand

Genomic View for RRS1 Gene

Genes around RRS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRS1 Gene

Proteins for RRS1 Gene

  • Protein details for RRS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribosome biogenesis regulatory protein homolog
    Protein Accession:
    Secondary Accessions:
    • Q9BUX8

    Protein attributes for RRS1 Gene

    365 amino acids
    Molecular mass:
    41193 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA04948.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RRS1 Gene

Post-translational modifications for RRS1 Gene

Other Protein References for RRS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RRS1 Gene

Domains & Families for RRS1 Gene

Protein Domains for RRS1 Gene

Suggested Antigen Peptide Sequences for RRS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RRS1 family.
  • Belongs to the RRS1 family.
genes like me logo Genes that share domains with RRS1: view

No data available for Gene Families for RRS1 Gene

Function for RRS1 Gene

Molecular function for RRS1 Gene

UniProtKB/Swiss-Prot Function:
Involved in ribosome biogenesis.

Gene Ontology (GO) - Molecular Function for RRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RRS1: view
genes like me logo Genes that share phenotypes with RRS1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRS1 Gene

Localization for RRS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRS1 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRS1 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 3
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000794 condensed nuclear chromosome IDA 19465021
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IEA,IDA 19465021
GO:0005783 endoplasmic reticulum IEA --
GO:0030687 preribosome, large subunit precursor IBA --
genes like me logo Genes that share ontologies with RRS1: view

Pathways & Interactions for RRS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000055 ribosomal large subunit export from nucleus IBA --
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0007080 mitotic metaphase plate congression IMP 19465021
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with RRS1: view

No data available for Pathways by source and SIGNOR curated interactions for RRS1 Gene

Transcripts for RRS1 Gene

mRNA/cDNA for RRS1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(133) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RRS1 Gene

RRS1 ribosome biogenesis regulator homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RRS1 Gene

No ASD Table

Relevant External Links for RRS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RRS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RRS1 Gene

Protein differential expression in normal tissues from HIPED for RRS1 Gene

This gene is overexpressed in Liver (18.2), Lung (16.5), Peripheral blood mononuclear cells (10.4), and Breast (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RRS1 Gene

Protein tissue co-expression partners for RRS1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RRS1 Gene:


SOURCE GeneReport for Unigene cluster for RRS1 Gene:

genes like me logo Genes that share expression patterns with RRS1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RRS1 Gene

Orthologs for RRS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RRS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RRS1 34 35
  • 94.41 (n)
(Canis familiaris)
Mammalia RRS1 34 35
  • 90.41 (n)
(Bos Taurus)
Mammalia RRS1 34 35
  • 89.77 (n)
(Mus musculus)
Mammalia Rrs1 34 16 35
  • 87.95 (n)
(Rattus norvegicus)
Mammalia Rrs1 34
  • 87.12 (n)
(Monodelphis domestica)
Mammalia RRS1 35
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia RRS1 35
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.641 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15190 34
(Danio rerio)
Actinopterygii rrs1 34 35
  • 63.59 (n)
wufj66c04 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2989 34
fruit fly
(Drosophila melanogaster)
Insecta CG32409 34 35
  • 54.05 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006808 34
  • 51.84 (n)
(Caenorhabditis elegans)
Secernentea rrbs-1 34 35
  • 50.86 (n)
C15H11.9 36
  • 45 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL014C 34
  • 55.56 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13046g 34
  • 50.99 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRS1 34 35 37
  • 48.34 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G37990 34
  • 46.91 (n)
(Oryza sativa)
Liliopsida Os04g0685100 34
  • 48.96 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08121 34
  • 51.88 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rrs1 34
  • 47.01 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.984 35
  • 47 (a)
Species where no ortholog for RRS1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRS1 Gene

Gene Tree for RRS1 (if available)
Gene Tree for RRS1 (if available)

Paralogs for RRS1 Gene

No data available for Paralogs for RRS1 Gene

Variants for RRS1 Gene

Sequence variations from dbSNP and Humsavar for RRS1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10093516 -- 66,430,975(+) GACAC(G/T)GTGGC intron-variant, upstream-variant-2KB
rs111453020 -- 66,429,649(+) CGCCA(A/G)GCGGA intron-variant, upstream-variant-2KB, reference, missense
rs113070119 -- 66,427,833(+) GTTTT(A/G)TGTTT intron-variant, upstream-variant-2KB
rs11556131 -- 66,429,309(+) AGGCC(G/T)AGCTA intron-variant, upstream-variant-2KB, reference, stop-gained
rs115935831 -- 66,430,017(+) AGGAG(A/G)ACCAG intron-variant, upstream-variant-2KB, reference, missense

Variation tolerance for RRS1 Gene

Residual Variation Intolerance Score: 81.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.02; 74.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RRS1 Gene

Disorders for RRS1 Gene

Relevant External Links for RRS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RRS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRS1 Gene

Publications for RRS1 Gene

  1. A nucleolar protein RRS1 contributes to chromosome congression. (PMID: 19465021) Gambe A.E. … Fukui K. (FEBS Lett. 2009) 2 3 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4 64
  4. RRS1, a conserved essential gene, encodes a novel regulatory protein required for ribosome biogenesis in Saccharomyces cerevisiae. (PMID: 10688653) Tsuno A. … Mizuta K. (Mol. Cell. Biol. 2000) 2 3 64
  5. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T. … Nomura N. (DNA Res. 1995) 3 4 64

Products for RRS1 Gene

Sources for RRS1 Gene

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