RRS1 Gene
protein-coding GIFtS: 51
GCID: GC08P067341
|
|
RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
| |
Aliases for RRS1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| RRS1 Ribosome Biogenesis Regulator Homolog (S. Cerevisiae)1 2 | | Ribosome Biogenesis Regulatory Protein Homolog2 | | KIAA01121 3 | | Ribosome Biogenesis Regulatory Protein RRS1 Homolog2 | | Homolog Of Yeast Ribosome Biogenesis Regulator2 | | RRR3 | | Homolog Of Yeast Ribosome Biogenesis Regulatory Protein RRS12 | | FSDR25 |
Export aliases for RRS1 gene to outside databasesPrevious GC identifers: GC08P066460 GC08P067280 GC08P067064 GC08P067391 GC08P067503 GC08P062831 |
Summaries for RRS1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: RRS1_HUMAN, Q15050Function: Involved in ribosome biogenesis (By similarity) Gene Wiki entry for RRS1
|
Genomic Views for RRS1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RRS1 gene promoter: HEN1 GR NRF-2 AML1a GR-beta Nkx2-5 GR-alpha Other transcription factors
Search SABiosciences Chromatin IP Primers for RRS1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RRS1 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q13.1 Ensembl cytogenetic band: 8q13.1 HGNC cytogenetic band: 8q12.3RRS1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P067341: view genomic region
(about GC identifiers)
Start:
|
67,341,263 bp from pter |
End:
|
67,342,968 bp from pter |
Size:
|
1,706 bases |
Orientation:
|
plus strand |
|
Proteins for RRS1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: RRS1_HUMAN, Q15050 (See
protein sequence)Recommended Name: Ribosome biogenesis regulatory protein homolog Size: 365 amino acids; 41193 Da
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=BAA04948.1; Type=Erroneous initiation;
Secondary accessions: Q9BUX8Explore the universe of human proteins at neXtProt for RRS1: NX_Q15050
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15050 RRS1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055984.1 ENSEMBL proteins: ENSP00000322396 Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RRS1 for ontologies About GeneDecksing
RRS1 Antibody Products: Assay Products for RRS1: |
Protein
Domains / Families for RRS1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RRS1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q15050ProtoNet protein and cluster: Q15050 1 Blocks protein family: IPB007023 Ribosomal biogenesis regulatory protein
UniProtKB/Swiss-Prot: RRS1_HUMAN, Q15050Similarity: Belongs to the RRS1 family |
Function for RRS1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: RRS1_HUMAN, Q15050Function: Involved in ribosome biogenesis (By similarity)
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RRS1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RRS1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RRS1 (NM_015169) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RRS1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRS1  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRS1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0005515 | protein binding |
-- | -- |
RRS1 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for RRS1:
|
Pathways & Interactions for RRS1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RRS1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/43 Interacting proteins for RRS1 (Q150502, 3 ENSP000003223964) via UniProtKB, MINT, STRING, and/or I2D (see all 43)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
RRS1 for ontologies About GeneDecksing
|
Drugs & Compounds for RRS1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for RRS1 Search CenterWatch for drugs/clinical trials and news about RRS1 
|
Transcripts for RRS1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for RRS1 gene: NM_015169.3 Unigene Cluster for RRS1: RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) Hs.71827 [show with all ESTs]Unigene Representative Sequence: NM_0151691 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000320270(uc003xwa.3)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RRS1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RRS1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RRS1 (NM_015169) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RRS1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRS1  |
Additional cDNA sequence: AK024716.1 BC001811.2 BC013043.2 D25218.1 5 DOTS entries: DT.412746 DT.97843905 DT.100701289 DT.99934485 DT.121477851 24/133 AceView cDNA sequences (see all 133): AI190957 CR607844 AW614528 BU163897 BC001811 BM990462 BC013043 AI332995 NM_015169 BP338492 BG109137 CR625499 CR622558 CA431075 CR592451 BF939144 CA422798 BM849202 D25218 BM555759 AW471485 H22075 BQ001335 AI674449 GeneLoc Exon Structure
|
Expression for RRS1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RRS1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AACAGCAAGA
About this image See RRS1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RRS1
SOURCE GeneReport for Unigene cluster: Hs.71827 SABiosciences Custom PCR Arrays for RRS1
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RRS1 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RRS1 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RRS1 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RRS1 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRS1 |
Orthologs for RRS1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RRS1 gene from 8/32 species (see all 32) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Rrs11 , 5 |
RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)1, 5 |
87.95(n)1 90.68(a)1 |
  |
1 (2.08 cM)5 590141 NM_021511.21 NP_067486.21 95454085 |
African clawed frog (Xenopus laevis) |
Amphibia |
Xl.151902 |
Xenopus laevis transcribed sequence with weak similarity more |
74.85(n) |
  |
BQ731831.1 |
zebrafish (Danio rerio) |
Actinopterygii |
wufj66c042 |
wufj66c04 |
74.19(n) |
  |
337399 BC055615.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
CG324091 |
CG32409 |
52.75(n) 45.35(a) |
  |
318016 NM_168144.2 NP_729108.2 |
worm (Caenorhabditis elegans) |
Secernentea |
C15H11.93 rrbs-11 |
Human HA0609 protein like3 Protein RRBS-11 |
45(a)3 49.62(n)1 43.73(a)1 |
  |
V(14426493-14427601)3 1799421 NM_074172.31 NP_506573.11 |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes |
RRS1(YOR294W)4 RRS11 |
Essential protein that binds ribosomal protein L11; more4 Rrs1p1 |
48.73(n)1 43.86(a)1 |
  |
15(868340-868951)4 8544691, 4 NP_014937.11, 4 |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
AT2G379901 |
ribosome biogenesis regulatory protein-like protein |
47.08(n) 40.88(a) |
  |
818377 NM_129356.3 NP_565878.1 |
rice (Oryza sativa) |
Liliopsida |
Os04g06851001 |
hypothetical protein |
48.39(n) 40.5(a) |
  |
4337459 NM_001060850.1 NP_001054315.1 |
ENSEMBL Gene Tree for RRS1 (if available) TreeFam Gene Tree for RRS1 (if available)  |
Paralogs for RRS1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for RRS1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 8 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for RRS1 (67341263 - 67342968 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for RRS1: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RRS1 |
|
Disorders
/ Diseases for RRS1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RRS1 for disorders About GeneDecksing
OMIM gene information: 611578
OMIM disorders: --
4 diseases for RRS1: About MalaCardspelvic inflammatory disease salpingitis huntington's disease malaria Export disorders for RRS1 gene to outside databases
|
Publications for RRS1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RRS1 gene, integrated from 9 sources (see all 16): (articles sorted by number of sources associating them with RRS1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2, 3 Nagase T....Kotani H. (1995)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
- RRS1, a conserved essential gene, encodes a novel regulatory protein required for ribosome biogenesis in Saccharomyces cerevisiae. (PubMed id 10688653)1, 3 Tsuno A....Mizuta K. (2000)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- A catalogue of putative HIV-1 protease host cell subst rates. (PubMed id 22944692)1 Impens F....Gevaert K. (2012)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (2011)
- Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
|
External Searches for RRS1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RRS1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RRS1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing RRS1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for RRS1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RRS1 gene: Search GeneIP for patents involving RRS1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for RRS1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for RRS1 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RRS1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RRS1 | | OriGene Protein Over-expression Lysate for RRS1 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for RRS1 | | OriGene 3'-UTR Clone for RRS1 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RRS1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RRS1 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for RRS1 | | OriGene Custom Protein Services for RRS1 | | OriGene Custom Immunoassay Development | | |
| |  |
 |
| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RRS1 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RRS1 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RRS1 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RRS1 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RRS1 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RRS1 |
| |
 |  |  |  | |
| | | Search Tocris compounds for RRS1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | RRS1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRS1 |
|  |  |  | | | ThermoFisher Antibodies for RRS1 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRS1 |
|
|
|
|