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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RRP8 Gene

protein-coding   GIFtS: 51
GCID: GC11M006577

ribosomal RNA processing 8, methyltransferase, homolog (yeast)

(Previous name: KIAA0409 )
(Previous symbol: KIAA0409)
 Explore 4 diseases affiliated with
RRP8 via our new
 Human Malady Compendium 
Biological research products
for RRP8
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ribosomal RNA Processing 8, Methyltransferase, Homolog (Yeast)1 2     RRP8 Methyltransferase Homolog2
KIAA04091 2 3     EC 2.1.1.-3
Cerebral Protein 12 3     NML3
Nucleomethylin3     Nucleomethylin3
Ribosomal RNA-Processing Protein 82     

External Ids:    HGNC: 290301   Entrez Gene: 233782   Ensembl: ENSG000001322757   UniProtKB: O431593   

Export aliases for RRP8 gene to outside databases

Previous GC identifer: GC11M006280


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RRP8_HUMAN, O43159
Function: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates
silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The
eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio
activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1
and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a
methyltransferase. Its substrates are however unknown

Gene Wiki entry for RRP8 (KIAA0409)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RRP8 gene promoter:
         CRE-BP1   ATF-2   STAT3   ATF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RRP8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RRP8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

RRP8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RRP8 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M006577:  view genomic region     (about GC identifiers)

Start:
6,616,305 bp from pter      End:
6,624,850 bp from pter
Size:
8,546 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RRP8_HUMAN, O43159 (See protein sequence)
Recommended Name: Ribosomal RNA-processing protein 8  
Size: 456 amino acids; 50715 Da
Subunit: Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8
Subcellular location: Nucleus, nucleolus. Note=Localizes at rDNA locus
Sequence caution: Sequence=BAA23705.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for RRP8:
2ZFU (3D)    
Secondary accessions: Q7KZ78 Q9BVM6

Explore the universe of human proteins at neXtProt for RRP8: NX_O43159

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43159

  • RRP8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_056139.1  
    ENSEMBL proteins: 
     ENSP00000254605   ENSP00000436960   ENSP00000436246   ENSP00000435873  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: RRP8
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    Novus Biologicals RRP8 Protein
    Novus Biologicals RRP8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RRP8

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005677chromatin silencing complex IDA18485871
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--


    RRP8 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RRP8 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR023576 UbiE/COQ5_MeTrFase_CS
     IPR007823 Methyltransferase-rel

    Graphical View of Domain Structure for InterPro Entry O43159

    ProtoNet protein and cluster: O43159

    UniProtKB/Swiss-Prot: RRP8_HUMAN, O43159
    Similarity: Belongs to the methyltransferase superfamily. RRP8 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: RRP8_HUMAN, O43159
    Function: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates
    silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The
    eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio
    activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1
    and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a
    methyltransferase. Its substrates are however unknown

    Enzyme Number (IUBMB): EC 2.1.1.-1

    miRNA
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    miRTarBase miRNAs that target RRP8:
    hsa-let-7b (MIRT005242)

    OriGene 3'-UTR Clone: RRP8
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RRP8
    1 QIAGEN miScript miRNA Assays for microRNA that regulate RRP8:
    hsa-miR-4303
    SwitchGear 3'UTR luciferase reporter plasmidRRP8 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RRP8 (see all 4)
    OriGene shRNA RFP: RRP8
    OriGene siRNA: RRP8
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    GenScript: all cDNA clones in your preferred vector: RRP8 (NM_015324)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRP8

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18485871
    GO:0008168methyltransferase activity ----
    GO:0008757S-adenosylmethionine-dependent methyltransferase activity TAS18485871
    GO:0035064methylated histone residue binding IDA18485871


    RRP8 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for RRP8:
     Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for RRP8
        Chromatin Regulation / Acetylation



    RRP8 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RRP8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/68 Interacting proteins for RRP8 (O431591, 3 ENSP000002546054) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIRT1Q96EB61, 3, ENSP000002120154EBI-2008793,EBI-1802965 I2D: score=3 STRING: ENSP00000212015
    SUV39H1O434631, 3, ENSP000003658774EBI-2008793,EBI-349968 I2D: score=3 STRING: ENSP00000365877
    KIAA0020Q153973, ENSP000003809824I2D: score=2 STRING: ENSP00000380982
    BYSLQ138953, ENSP000002303404I2D: score=1 STRING: ENSP00000230340
    KPNB1Q149743, ENSP000002901584I2D: score=1 STRING: ENSP00000290158
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000183chromatin silencing at rDNA IDA18485871
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006364rRNA processing IEA--
    GO:0016568chromatin modification IEA--
    GO:0042149cellular response to glucose starvation IMP--


    RRP8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RRP8
    Search CenterWatch for drugs/clinical trials and news about RRP8 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RRP8 gene: 
    NM_015324.3  

    Unigene Cluster for RRP8:

    Ribosomal RNA processing 8, methyltransferase, homolog (yeast)
    Hs.652255  [show with all ESTs]
    Unigene Representative Sequence: AB007869
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254605(uc001med.3) ENST00000534343 ENST00000526352 ENST00000533907
    ENST00000530762

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate RRP8:
    hsa-miR-4303
    SwitchGear 3'UTR luciferase reporter plasmidRRP8 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RRP8 (see all 4)
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RRP8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RRP8

    Additional cDNA sequence: 

    AB007869.1 AK091817.1 BC001071.2 D87060.1 

    16 DOTS entries:

    DT.114795  DT.95294662  DT.100785203  DT.92441708  DT.120709576  DT.100785199  DT.87046008  DT.120709473 
    DT.120709543  DT.40128878  DT.91692217  DT.92441711  DT.100738911  DT.120709359  DT.95085372  DT.95294660 

    24/433 AceView cDNA sequences (see all 433):

    CA314349 BU734215 BC001071 NM_015324 AW793641 AI689878 AA923431 AI202687 
    AL539807 BQ613808 BM781911 AI370778 BC012088 AW793577 AI337083 BQ072896 
    AW470062 BX089762 BU932042 BE612595 BU188116 BM798795 BF063424 CR607023 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RRP8    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                                                                  
    SP2:                                                                  
    SP3:              -                                                   
    SP4:                                                                  


    ECgene alternative splicing isoforms for RRP8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RRP8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTCTACAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See RRP8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RRP8

    SOURCE GeneReport for Unigene cluster: Hs.652255
        SABiosciences Custom PCR Arrays for RRP8
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRP8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RRP8 gene from 9/29 species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rrp81 , 5 ribosomal RNA processing 8, methyltransferase, homolog more1, 5 81.39(n)1
    76.48(a)1
      7 (55.97 cM)5
    1018671  NM_025897.21  NP_080173.11 
     1057322075 
    chicken
    (Gallus gallus)
    Aves RRP81 KIAA0409 66.21(n)
    67.74(a)
      425225  XM_423009.3  XP_423009.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.163272 Xenopus laevis transcribed sequence with weak similarity more 75.36(n)    CF283925.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wu:fk33d071 wu:fk33d07 56.51(n)
    52.04(a)
      797198  XM_001334650.3  XP_001334686.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG71371 CG7137 49.63(n)
    41.85(a)
      37204  NM_137556.3  NP_611400.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T07A9.81 Protein T07A9.8 46.37(n)
    38.82(a)
      176864  NM_067519.3  NP_499920.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RRP8(YDR083W)4
    RRP81
    Nucleolar protein involved in rRNA processing, pre-rRNA more4
    Rrp8p1
    45.06(n)1
    40.39(a)1
      4(612073-613251)4
    8516561, 4  NP_010368.51  NP_010368.34 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G405301 ribosomal RNA-processing protein 8 50.38(n)
    48.08(a)
      834051  NM_123417.3  NP_198869.2 
    rice
    (Oryza sativa)
    Liliopsida Os02g05939001 hypothetical protein 49.81(n)
    44.11(a)
      4329847  NM_001053838.1  NP_001047303.1 


    ENSEMBL Gene Tree for RRP8 (if available)
    TreeFam Gene Tree for RRP8 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/80 NCBI SNPs in RRP8 are shown (see all 80    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1921702891,2
    --6620656(+) GCCAAA/GAATTA 1 -- int10--------
    rs1856961791,2
    --6620722(+) TCCCAC/TAGGAC 1 -- int10--------
    rs79288521,2
    C,F,H,--6620756(+) TGCTAT/CATGGT 1 -- int1 ese312Minor allele frequency- C:0.03NS EA NA CSA 1264
    rs1430040601,2
    --6620876(+) AGATGC/TTGGTG 1 -- int10--------
    rs1178038601,2
    F,--6621004(+) AGACAG/TATCAG 1 -- int11Minor allele frequency- T:0.03EA 120
    rs1482069941,2
    --6621009(+) GATCAA/GATGAC 1 -- int10--------
    rs28901,2
    C,F,H,--6621225(+) TTCAGT/CAGAGC 1 -- ut31 ese310Minor allele frequency- C:0.08MN NS EA NA 724
    rs1420052451,2
    --6621275(+) GTCCAC/TCAGGA 1 -- ut310--------
    rs618758671,2
    C,F,--6621369(+) AAGATC/TCAGAG 1 -- ut313Minor allele frequency- T:0.01NA EU 1445
    rs1886599761,2
    C,--6621396(+) GAGACA/GTGGCT 2 R C mis10--------

    HapMap Linkage Disequilibrium report for RRP8 (6616305 - 6624850 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RRP8
         1 Indel: 58531

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RRP8
    DNA2.0 Custom Variant and Variant Library Synthesis for RRP8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RRP8 for disorders           About GeneDecksing

    4 diseases for RRP8:    About MalaCards
    bowen-conradi syndrome    cerebritis    hepatitis    malaria

    1 disease from the University of Copenhagen DISEASES database for RRP8:
    Bowen-Conradi syndrome

    Export disorders for RRP8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RRP8 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with RRP8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2, 3 Ishikawa K....Ohara O. (1997)
    2. Epigenetic control of rDNA loci in response to intracellular energy status. (PubMed id 18485871)1, 2 Murayama A.... Yanagisawa J. (2008)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
    6. Directed proteomic analysis of the human nucleolus. (PubMed id 11790298)1, 2 Andersen J.S.... Lamond A.I. (2002)
    7. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    8. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23378 HGNC: 29030 AceView: TAF10andKIAA0409 Ensembl:ENSG00000132275 euGenes: HUgn23378
    ECgene: RRP8 H-InvDB: RRP8

    (According to HUGE)
    About This Section
    HUGE: KIAA0409

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RRP8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RRP8 gene:
    Search GeneIP for patents involving RRP8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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