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Aliases for RRP8 Gene

Aliases for RRP8 Gene

  • Ribosomal RNA Processing 8, Methyltransferase, Homolog (Yeast) 2 3
  • KIAA0409 2 3 4
  • Cerebral Protein 1 3 4
  • Nucleomethylin 3 4
  • NML 3 4
  • RRP8 Methyltransferase Homolog (S. Cerevisiae) 2
  • Ribosomal RNA-Processing Protein 8 3
  • RRP8 Methyltransferase Homolog 3
  • EC 2.1.1.- 4

External Ids for RRP8 Gene

Previous HGNC Symbols for RRP8 Gene

  • KIAA0409

Previous GeneCards Identifiers for RRP8 Gene

  • GC11M006280

Summaries for RRP8 Gene

GeneCards Summary for RRP8 Gene

RRP8 (Ribosomal RNA Processing 8, Methyltransferase, Homolog (Yeast)) is a Protein Coding gene. Diseases associated with RRP8 include bowen-conradi syndrome. Among its related pathways are Chromatin Regulation / Acetylation. GO annotations related to this gene include methylated histone binding and S-adenosylmethionine-dependent methyltransferase activity.

UniProtKB/Swiss-Prot for RRP8 Gene

  • Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at Lys-9 (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.

Gene Wiki entry for RRP8 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRP8 Gene

Genomics for RRP8 Gene

Regulatory Elements for RRP8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RRP8 Gene

Start:
6,595,075 bp from pter
End:
6,603,650 bp from pter
Size:
8,576 bases
Orientation:
Minus strand

Genomic View for RRP8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RRP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRP8 Gene

Proteins for RRP8 Gene

  • Protein details for RRP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43159-RRP8_HUMAN
    Recommended name:
    Ribosomal RNA-processing protein 8
    Protein Accession:
    O43159
    Secondary Accessions:
    • Q7KZ78
    • Q9BVM6

    Protein attributes for RRP8 Gene

    Size:
    456 amino acids
    Molecular mass:
    50715 Da
    Quaternary structure:
    • Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8.
    SequenceCaution:
    • Sequence=BAA23705.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RRP8 Gene

neXtProt entry for RRP8 Gene

Proteomics data for RRP8 Gene at MOPED

Post-translational modifications for RRP8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RRP8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RRP8 Gene

Domains for RRP8 Gene

Protein Domains for RRP8 Gene

Suggested Antigen Peptide Sequences for RRP8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43159

UniProtKB/Swiss-Prot:

RRP8_HUMAN :
  • O43159
Family:
  • Belongs to the methyltransferase superfamily. RRP8 family.
genes like me logo Genes that share domains with RRP8: view

No data available for Gene Families for RRP8 Gene

Function for RRP8 Gene

Molecular function for RRP8 Gene

UniProtKB/Swiss-Prot Function: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at Lys-9 (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.

Enzyme Numbers (IUBMB) for RRP8 Gene

Gene Ontology (GO) - Molecular Function for RRP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18485871
GO:0008168 methyltransferase activity --
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity TAS 18485871
GO:0035064 methylated histone binding IDA 18485871
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RRP8: view

Phenotypes for RRP8 Gene

GenomeRNAi human phenotypes for RRP8:
genes like me logo Genes that share phenotypes with RRP8: view

Animal Model Products

CRISPR Products

miRNA for RRP8 Gene

miRTarBase miRNAs that target RRP8

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RRP8

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RRP8 Gene

Localization for RRP8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRP8 Gene

Nucleus, nucleolus. Note=Localizes at rDNA locus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RRP8 Gene COMPARTMENTS Subcellular localization image for RRP8 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for RRP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005677 chromatin silencing complex IDA 18485871
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with RRP8: view

Pathways for RRP8 Gene

genes like me logo Genes that share pathways with RRP8: view

Pathways by source for RRP8 Gene

1 Cell Signaling Technology pathway for RRP8 Gene

Gene Ontology (GO) - Biological Process for RRP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006364 rRNA processing IEA --
GO:0008152 metabolic process --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with RRP8: view

Transcripts for RRP8 Gene

Unigene Clusters for RRP8 Gene

Ribosomal RNA processing 8, methyltransferase, homolog (yeast):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RRP8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RRP8 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2:
SP3: -
SP4:

Relevant External Links for RRP8 Gene

GeneLoc Exon Structure for
RRP8
ECgene alternative splicing isoforms for
RRP8

Expression for RRP8 Gene

mRNA expression in normal human tissues for RRP8 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RRP8 Gene

SOURCE GeneReport for Unigene cluster for RRP8 Gene Hs.652255

genes like me logo Genes that share expressions with RRP8: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RRP8 Gene

Orthologs for RRP8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RRP8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RRP8 35
  • 99.63 (n)
  • 99.34 (a)
RRP8 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RRP8 35
  • 84.36 (n)
  • 79.61 (a)
RRP8 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RRP8 35
  • 85.06 (n)
  • 81.02 (a)
RRP8 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rrp8 35
  • 80.88 (n)
  • 76.26 (a)
Rrp8 16
Rrp8 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rrp8 35
  • 80.32 (n)
  • 75.33 (a)
chicken
(Gallus gallus)
Aves RRP8 35
  • 66.04 (n)
  • 66.98 (a)
RRP8 36
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16327 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498652 35
  • 60.15 (n)
  • 54.51 (a)
Str.5831 35
zebrafish
(Danio rerio)
Actinopterygii RRP8 36
  • 32 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7137 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T07A9.8 36
  • 37 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRP8 36
  • 31 (a)
OneToOne
RRP8 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G40530 35
  • 50 (n)
  • 48.08 (a)
rice
(Oryza sativa)
Liliopsida Os02g0593900 35
  • 51.24 (n)
  • 47.6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3651 36
  • 37 (a)
OneToOne
Species with no ortholog for RRP8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRP8 Gene

ENSEMBL:
Gene Tree for RRP8 (if available)
TreeFam:
Gene Tree for RRP8 (if available)

Paralogs for RRP8 Gene

No data available for Paralogs for RRP8 Gene

Variants for RRP8 Gene

Sequence variations from dbSNP and Humsavar for RRP8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2890 -- 6,599,995(+) TTCAG(C/T)AGAGC utr-variant-3-prime
rs2288283 -- 6,601,484(+) CTCTT(A/G)TTCTT reference, synonymous-codon
rs7928852 -- 6,599,526(+) TGCTA(C/T)ATGGT downstream-variant-500B
rs11040933 -- 6,600,286(+) ACCCA(A/G)TGAGA intron-variant
rs11603397 -- 6,600,686(+) ACTCT(A/G)TTTGC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for RRP8 Gene

Variant ID Type Subtype PubMed ID
nsv825755 CNV Gain 20364138
esv996362 CNV Deletion 20482838
nsv819272 CNV Loss 19587683
nsv896971 CNV Loss 21882294

Relevant External Links for RRP8 Gene

HapMap Linkage Disequilibrium report
RRP8
Human Gene Mutation Database (HGMD)
RRP8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRP8 Gene

Disorders for RRP8 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RRP8 Gene including...

Search for RRP8 Gene in MalaCards »

(1) University of Copenhagen DISEASES for RRP8 Gene

genes like me logo Genes that share disorders with RRP8: view

No data available for UniProtKB/Swiss-Prot for RRP8 Gene

Publications for RRP8 Gene

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 2 3 4
  2. Directed proteomic analysis of the human nucleolus. (PMID: 11790298) Andersen J.S. … Lamond A.I. (Curr. Biol. 2002) 3 4
  3. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for RRP8 Gene

Sources for RRP8 Gene

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