Aliases for RRP8 Gene
External Ids for RRP8 Gene
Previous Symbols for RRP8 Gene
GeneCards Summary for RRP8 Gene
RRP8 (Ribosomal RNA Processing 8, Methyltransferase, Homolog (Yeast)) is a Protein Coding gene. Diseases associated with RRP8 include bowen-conradi syndrome. Among its related pathways are Chromatin Regulation / Acetylation. GO annotations related to this gene include methylated histone binding and S-adenosylmethionine-dependent methyltransferase activity.
UniProtKB/Swiss-Prot for RRP8 Gene
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at Lys-9 (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.