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Aliases for RRP7A Gene

Aliases for RRP7A Gene

  • Ribosomal RNA Processing 7 Homolog A 2 3 5
  • Gastric Cancer Antigen Zg14 3 4
  • Ribosomal RNA Processing 7 Homolog A (S. Cerevisiae) 2
  • Ribosomal RNA-Processing Protein 7 Homolog A 3
  • CTA-126B4.5 3
  • BK126B4.3 3
  • CGI-96 3

External Ids for RRP7A Gene

Previous GeneCards Identifiers for RRP7A Gene

  • GC22M041238
  • GC22M042905

Summaries for RRP7A Gene

GeneCards Summary for RRP7A Gene

RRP7A (Ribosomal RNA Processing 7 Homolog A) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and nucleotide binding.

Gene Wiki entry for RRP7A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRP7A Gene

Genomics for RRP7A Gene

Regulatory Elements for RRP7A Gene

Enhancers for RRP7A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G042518 1.3 ENCODE dbSUPER 17 -0.2 -206 2.6 HDGF PKNOX1 FOXA2 ATF1 ARID4B E2F7 SIN3A DMAP1 ZNF48 YY1 RRP7A RRP7BP CSDC2 GC22P042549
GH22G042532 1.5 Ensembl ENCODE dbSUPER 14.1 -13.5 -13532 1.8 PKNOX1 ATF1 ARID4B ZNF143 ZNF207 FOS SP5 JUNB REST TBX21 RRP7A RRP7BP GC22P042549
GH22G042536 1.5 Ensembl ENCODE dbSUPER 13.1 -17.5 -17542 2.2 HDGF PKNOX1 ATF1 FOXA2 MLX ARID4B ZNF48 ZNF121 SLC30A9 ZNF143 RRP7BP RRP7A SERHL2 SMDT1 CSDC2 GC22P042549
GH22G042498 1.2 ENCODE dbSUPER 15.5 +20.1 20121 3.3 PKNOX1 TCF12 JUNB TBX21 ZNF592 ZNF579 MEF2D MBD2 SMARCA4 SP7 RRP7A RRP7BP NFAM1 CYB5R3 SERHL LOC101927344
GH22G042511 1 ENCODE dbSUPER 16.3 +7.8 7834 1.9 CTCF TFAP4 AGO1 CEBPG ZIC2 RAD21 ZFHX2 POLR2A SCRT2 EGR2 RRP7BP RRP7A CYB5R3 PIR44189 GC22P042508
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RRP7A on UCSC Golden Path with GeneCards custom track

Promoters for RRP7A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000146772 323 1001 PKNOX1 ARID4B E2F7 SIN3A DMAP1 ZNF48 YY1 ETS1 GLIS2 ZNF207

Genomic Location for RRP7A Gene

Chromosome:
22
Start:
42,508,335 bp from pter
End:
42,519,823 bp from pter
Size:
11,489 bases
Orientation:
Minus strand

Genomic View for RRP7A Gene

Genes around RRP7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRP7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRP7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRP7A Gene

Proteins for RRP7A Gene

  • Protein details for RRP7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3A4-RRP7A_HUMAN
    Recommended name:
    Ribosomal RNA-processing protein 7 homolog A
    Protein Accession:
    Q9Y3A4
    Secondary Accessions:
    • A4FTX2
    • B2RBG4
    • Q0VAD0
    • Q5JZ94
    • Q6P4B5
    • Q8IVR9
    • Q8IVY0
    • Q8N5Q3
    • Q8NEY6
    • Q9Y3H5

    Protein attributes for RRP7A Gene

    Size:
    280 amino acids
    Molecular mass:
    32334 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH31838.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RRP7A Gene

Post-translational modifications for RRP7A Gene

  • Ubiquitination at Lys33 and Lys149
  • Modification sites at PhosphoSitePlus

Other Protein References for RRP7A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RRP7A Gene

Domains & Families for RRP7A Gene

Protein Domains for RRP7A Gene

Suggested Antigen Peptide Sequences for RRP7A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3A4

UniProtKB/Swiss-Prot:

RRP7A_HUMAN :
  • Belongs to the RRP7 family.
Family:
  • Belongs to the RRP7 family.
genes like me logo Genes that share domains with RRP7A: view

No data available for Gene Families for RRP7A Gene

Function for RRP7A Gene

Gene Ontology (GO) - Molecular Function for RRP7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 22658674
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RRP7A: view

Phenotypes for RRP7A Gene

GenomeRNAi human phenotypes for RRP7A:
genes like me logo Genes that share phenotypes with RRP7A: view

Animal Model Products

CRISPR Products

miRNA for RRP7A Gene

miRTarBase miRNAs that target RRP7A

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRP7A Gene

Localization for RRP7A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRP7A gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2

Gene Ontology (GO) - Cellular Components for RRP7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0032545 CURI complex IBA --
GO:0034456 UTP-C complex IBA --
genes like me logo Genes that share ontologies with RRP7A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RRP7A Gene

Pathways & Interactions for RRP7A Gene

genes like me logo Genes that share pathways with RRP7A: view

Gene Ontology (GO) - Biological Process for RRP7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000028 ribosomal small subunit assembly IBA --
GO:0001825 blastocyst formation IEA --
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with RRP7A: view

No data available for SIGNOR curated interactions for RRP7A Gene

Drugs & Compounds for RRP7A Gene

No Compound Related Data Available

Transcripts for RRP7A Gene

mRNA/cDNA for RRP7A Gene

Unigene Clusters for RRP7A Gene

Ribosomal RNA processing 7 homolog A (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RRP7A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -
SP3: - -

Relevant External Links for RRP7A Gene

GeneLoc Exon Structure for
RRP7A
ECgene alternative splicing isoforms for
RRP7A

Expression for RRP7A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RRP7A Gene

Protein differential expression in normal tissues from HIPED for RRP7A Gene

This gene is overexpressed in CD8 Tcells (14.7), Pancreas (12.9), Peripheral blood mononuclear cells (9.1), and Blymphocyte (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RRP7A Gene



Protein tissue co-expression partners for RRP7A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RRP7A Gene:

RRP7A

SOURCE GeneReport for Unigene cluster for RRP7A Gene:

Hs.745006

Evidence on tissue expression from TISSUES for RRP7A Gene

  • Nervous system(4.9)
  • Intestine(4.3)
  • Liver(4.2)
  • Lung(2.7)
  • Eye(2)
genes like me logo Genes that share expression patterns with RRP7A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RRP7A Gene

Orthologs for RRP7A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RRP7A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 94 (a)
OneToMany
-- 35
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RRP7A 34 35
  • 86.37 (n)
rat
(Rattus norvegicus)
Mammalia Rrp7a 34
  • 83.57 (n)
mouse
(Mus musculus)
Mammalia Rrp7a 34 16 35
  • 82.74 (n)
cow
(Bos Taurus)
Mammalia RRP7A 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RRP7A 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RRP7A 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves RRP7A 34 35
  • 66.91 (n)
lizard
(Anolis carolinensis)
Reptilia RRP7A 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rrp7a 34
  • 61.83 (n)
Str.10145 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15159 34
zebrafish
(Danio rerio)
Actinopterygii rrp7a 34 35
  • 56.68 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7695 34
fruit fly
(Drosophila melanogaster)
Insecta CG9107 34 35
  • 52.08 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001656 34
  • 49.8 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRP7 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2355 35
  • 37 (a)
OneToOne
Species where no ortholog for RRP7A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RRP7A Gene

ENSEMBL:
Gene Tree for RRP7A (if available)
TreeFam:
Gene Tree for RRP7A (if available)

Paralogs for RRP7A Gene

(1) SIMAP similar genes for RRP7A Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RRP7A Gene

genes like me logo Genes that share paralogs with RRP7A: view

No data available for Paralogs for RRP7A Gene

Variants for RRP7A Gene

Sequence variations from dbSNP and Humsavar for RRP7A Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000237348 -- 42,519,634(+) CTGGG(A/G)ACCCC intron-variant
rs1000453511 -- 42,510,506(+) CAGCT(A/G)TGGGA intron-variant, utr-variant-3-prime
rs1000749859 -- 42,514,885(+) CCGGG(A/G)CACAG intron-variant
rs1001187455 -- 42,518,499(+) GACCT(C/G)TTCTC intron-variant
rs1001238180 -- 42,518,855(+) GGTCC(C/T)TGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RRP7A Gene

Variant ID Type Subtype PubMed ID
dgv101e203 CNV gain+loss 21179565
dgv103e180 CNV gain 20482838
dgv1321e212 CNV gain 25503493
dgv173n111 CNV duplication 26073780
dgv174n111 CNV duplication 26073780
dgv175n111 CNV duplication 26073780
dgv4576n100 CNV gain 25217958
dgv4577n100 CNV gain 25217958
dgv4578n100 CNV gain 25217958
dgv4579n100 CNV gain+loss 25217958
dgv4580n100 CNV gain+loss 25217958
dgv4581n100 CNV gain 25217958
dgv4582n100 CNV gain+loss 25217958
dgv4583n100 CNV gain+loss 25217958
dgv4584n100 CNV gain 25217958
dgv4585n100 CNV gain 25217958
dgv734e201 CNV deletion 23290073
dgv773n67 CNV gain 20364138
dgv8117n54 CNV gain 21841781
dgv842e214 CNV gain 21293372
esv2659886 CNV deletion 23128226
esv2724283 CNV deletion 23290073
esv2758839 CNV gain+loss 17122850
esv28197 CNV gain 19812545
esv32632 CNV gain 17666407
esv3568421 CNV loss 25503493
esv3575487 CNV gain 25503493
esv3575488 CNV gain 25503493
esv3647831 CNV loss 21293372
nsv1055597 CNV gain 25217958
nsv1056323 CNV loss 25217958
nsv1062078 CNV loss 25217958
nsv1160770 CNV duplication 26073780
nsv1160775 CNV deletion 26073780
nsv428391 CNV gain 18775914
nsv436074 CNV insertion 17901297
nsv442798 CNV gain+loss 18776908
nsv482078 CNV gain 20164927
nsv511642 CNV loss 21212237
nsv589065 CNV gain 21841781
nsv589071 CNV loss 21841781
nsv829246 CNV loss 20364138
nsv9912 CNV gain+loss 18304495

Variation tolerance for RRP7A Gene

Residual Variation Intolerance Score: 95.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.00; 84.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRP7A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RRP7A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRP7A Gene

Disorders for RRP7A Gene

Relevant External Links for RRP7A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RRP7A

No disorders were found for RRP7A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRP7A Gene

Publications for RRP7A Gene

  1. Serological identification and expression analysis of gastric cancer- associated genes. (PMID: 12087473) Line A. … Rees R.C. (Br. J. Cancer 2002) 2 3 4 64
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4 64

Products for RRP7A Gene

Sources for RRP7A Gene

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