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Aliases for RRP36 Gene

Aliases for RRP36 Gene

  • Ribosomal RNA Processing 36 2 3 5
  • C6orf153 3 4
  • Ribosomal RNA Processing 36 Homolog (S. Cerevisiae) 2
  • Ribosomal RNA Processing Protein 36 Homolog 3
  • Chromosome 6 Open Reading Frame 153 2
  • Ribosomal RNA Processing 36 Homolog 3
  • RNA Processing Factor 3
  • DJ20C7.4 3

External Ids for RRP36 Gene

Previous HGNC Symbols for RRP36 Gene

  • C6orf153

Previous GeneCards Identifiers for RRP36 Gene

  • GC06P042993
  • GC06P042706
  • GC06P042995
  • GC06P043000
  • GC06P043002
  • GC06P043009

Summaries for RRP36 Gene

Entrez Gene Summary for RRP36 Gene

  • RRP36 functions at an early stage in the processing of 35S preribosomal RNA into the mature 18S species (Gerus et al., 2010 [PubMed 20038530]).[supplied by OMIM, Jul 2010]

GeneCards Summary for RRP36 Gene

RRP36 (Ribosomal RNA Processing 36) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for RRP36 Gene

  • Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRP36 Gene

Genomics for RRP36 Gene

Regulatory Elements for RRP36 Gene

Enhancers for RRP36 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G043624 1.4 ENCODE dbSUPER 34.3 +606.4 606403 7.4 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC MEF2D POLH RRP36 RPS2P29 CUL7 SRF ENSG00000271754 BICRAL MYMX YIPF3 RSPH9
GH06G043801 2.1 FANTOM5 Ensembl ENCODE dbSUPER 22.1 +783.7 783698 6.9 MLX CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 POLH RPS2P29 CUL7 RRP36 ENSG00000272223 MYMX PEX6 VEGFA YIPF3 ENSG00000271754
GH06G043810 1.6 Ensembl ENCODE dbSUPER 22.1 +791.0 790959 5.8 HDGF PKNOX1 FOXA2 FEZF1 ZNF2 ZNF302 ZNF548 PAF1 SP3 REST POLH RPS2P29 RRP36 RPL34P14 CUL7 VEGFA YIPF3 ENSG00000271754 CDC5L LOC105375070
GH06G043765 1.4 ENCODE dbSUPER 21.4 +749.8 749767 11.5 MLX CREB3L1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MEF2D POLH RRP36 RPS2P29 CUL7 ENSG00000272223 PEX6 YIPF3 RPL34P14 CUL9 AARS2
GH06G043266 2 FANTOM5 Ensembl ENCODE dbSUPER 14.8 +251.8 251817 13.1 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF416 ZNF263 SP3 CUL7 POLH RPS2P29 RRP36 KLC4 ENSG00000271754 DNPH1 UBR2 ENSG00000271970 CUL9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RRP36 on UCSC Golden Path with GeneCards custom track

Promoters for RRP36 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000197077 464 1401 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A FEZF1 DMAP1 YY1

Genomic Location for RRP36 Gene

Chromosome:
6
Start:
43,021,636 bp from pter
End:
43,034,156 bp from pter
Size:
12,521 bases
Orientation:
Plus strand

Genomic View for RRP36 Gene

Genes around RRP36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRP36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRP36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRP36 Gene

Proteins for RRP36 Gene

  • Protein details for RRP36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EU6-RRP36_HUMAN
    Recommended name:
    Ribosomal RNA processing protein 36 homolog
    Protein Accession:
    Q96EU6
    Secondary Accessions:
    • Q9BRF6
    • Q9P0C8

    Protein attributes for RRP36 Gene

    Size:
    259 amino acids
    Molecular mass:
    29823 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Meningioma antigen.
    SequenceCaution:
    • Sequence=AAH06293.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RRP36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RRP36 Gene

Post-translational modifications for RRP36 Gene

  • Ubiquitination at isoforms=2225
  • Modification sites at PhosphoSitePlus

Other Protein References for RRP36 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RRP36 Gene

Domains & Families for RRP36 Gene

Protein Domains for RRP36 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RRP36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96EU6

UniProtKB/Swiss-Prot:

RRP36_HUMAN :
  • Belongs to the RRP36 family.
Family:
  • Belongs to the RRP36 family.
genes like me logo Genes that share domains with RRP36: view

No data available for Gene Families for RRP36 Gene

Function for RRP36 Gene

Molecular function for RRP36 Gene

UniProtKB/Swiss-Prot Function:
Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA.

Gene Ontology (GO) - Molecular Function for RRP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RRP36: view

Phenotypes for RRP36 Gene

GenomeRNAi human phenotypes for RRP36:
genes like me logo Genes that share phenotypes with RRP36: view

Animal Model Products

CRISPR Products

miRNA for RRP36 Gene

miRTarBase miRNAs that target RRP36

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRP36 Gene

Localization for RRP36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRP36 Gene

Nucleus, nucleolus. Note=Concentrated in the fibrillar region of the nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRP36 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for RRP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA,IDA 20038530
GO:0030686 90S preribosome IBA --
genes like me logo Genes that share ontologies with RRP36: view

Pathways & Interactions for RRP36 Gene

genes like me logo Genes that share pathways with RRP36: view

Gene Ontology (GO) - Biological Process for RRP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0000469 cleavage involved in rRNA processing IEA --
GO:0006364 rRNA processing TAS --
GO:0042254 ribosome biogenesis IEA --
GO:0042274 ribosomal small subunit biogenesis IDA 20038530
genes like me logo Genes that share ontologies with RRP36: view

No data available for SIGNOR curated interactions for RRP36 Gene

Drugs & Compounds for RRP36 Gene

No Compound Related Data Available

Transcripts for RRP36 Gene

mRNA/cDNA for RRP36 Gene

Unigene Clusters for RRP36 Gene

Ribosomal RNA processing 36 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RRP36 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - - - -
SP3:
SP4:

Relevant External Links for RRP36 Gene

GeneLoc Exon Structure for
RRP36
ECgene alternative splicing isoforms for
RRP36

Expression for RRP36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RRP36 Gene

Protein differential expression in normal tissues from HIPED for RRP36 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (32.9), Testis (7.6), CD8 Tcells (7.6), and Blymphocyte (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RRP36 Gene



Protein tissue co-expression partners for RRP36 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RRP36 Gene:

RRP36

SOURCE GeneReport for Unigene cluster for RRP36 Gene:

Hs.309231

Evidence on tissue expression from TISSUES for RRP36 Gene

  • Pancreas(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with RRP36: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RRP36 Gene

Orthologs for RRP36 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RRP36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RRP36 34 35
  • 98.84 (n)
dog
(Canis familiaris)
Mammalia RRP36 34
  • 89.8 (n)
cow
(Bos Taurus)
Mammalia RRP36 34
  • 85.79 (n)
rat
(Rattus norvegicus)
Mammalia Rrp36 34
  • 85.56 (n)
mouse
(Mus musculus)
Mammalia Rrp36 34 16 35
  • 83.41 (n)
oppossum
(Monodelphis domestica)
Mammalia RRP36 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858699 34
  • 59.82 (n)
RRP36 35
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RRP36 35
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rrp36 34 35
  • 58.41 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3045 34
fruit fly
(Drosophila melanogaster)
Insecta CG8461 34 35
  • 49.53 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002333 34
  • 44.92 (n)
worm
(Caenorhabditis elegans)
Secernentea T22H9.1 35
  • 14 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRP36 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G12650 34
  • 48.48 (n)
rice
(Oryza sativa)
Liliopsida Os09g0525200 34
  • 47.12 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToOne
Species where no ortholog for RRP36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RRP36 Gene

ENSEMBL:
Gene Tree for RRP36 (if available)
TreeFam:
Gene Tree for RRP36 (if available)

Paralogs for RRP36 Gene

No data available for Paralogs for RRP36 Gene

Variants for RRP36 Gene

Sequence variations from dbSNP and Humsavar for RRP36 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1001475564 -- 43,021,236(+) GCTGT(C/T)GCTGT nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1001623925 -- 43,026,646(+) CCAAC(C/T)TGGGC intron-variant
rs1001819790 -- 43,021,489(+) GACAA(C/T)GTCTC downstream-variant-500B, upstream-variant-2KB
rs1001918158 -- 43,025,408(+) CCTGA(C/G)ATCAG intron-variant
rs1002242809 -- 43,023,611(+) CGCTT(C/G)AACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RRP36 Gene

Variant ID Type Subtype PubMed ID
dgv10640n54 CNV loss 21841781
nsv1017398 CNV gain 25217958
nsv462927 CNV loss 19166990
nsv462930 CNV loss 19166990
nsv602992 CNV loss 21841781

Variation tolerance for RRP36 Gene

Residual Variation Intolerance Score: 69.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.48; 71.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRP36 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RRP36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRP36 Gene

Disorders for RRP36 Gene

Relevant External Links for RRP36

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RRP36

No disorders were found for RRP36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRP36 Gene

Publications for RRP36 Gene

  1. Evolutionarily conserved function of RRP36 in early cleavages of the pre-rRNA and production of the 40S ribosomal subunit. (PMID: 20038530) Gerus M. … Henras A.K. (Mol. Cell. Biol. 2010) 2 3 4 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. Complex humoral immune response against a benign tumor: frequent antibody response against specific antigens as diagnostic targets. (PMID: 15983380) Comtesse N. … Meese E. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64

Products for RRP36 Gene

Sources for RRP36 Gene

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