Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RRP36 Gene

Aliases for RRP36 Gene

  • Ribosomal RNA Processing 36 2 3 5
  • C6orf153 3 4
  • Ribosomal RNA Processing 36 Homolog (S. Cerevisiae) 2
  • Ribosomal RNA Processing Protein 36 Homolog 3
  • Chromosome 6 Open Reading Frame 153 2
  • Ribosomal RNA Processing 36 Homolog 3
  • RNA Processing Factor 3
  • DJ20C7.4 3

External Ids for RRP36 Gene

Previous HGNC Symbols for RRP36 Gene

  • C6orf153

Previous GeneCards Identifiers for RRP36 Gene

  • GC06P042993
  • GC06P042706
  • GC06P042995
  • GC06P043000
  • GC06P043002
  • GC06P043009

Summaries for RRP36 Gene

Entrez Gene Summary for RRP36 Gene

  • RRP36 functions at an early stage in the processing of 35S preribosomal RNA into the mature 18S species (Gerus et al., 2010 [PubMed 20038530]).[supplied by OMIM, Jul 2010]

GeneCards Summary for RRP36 Gene

RRP36 (Ribosomal RNA Processing 36) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for RRP36 Gene

  • Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA.

Additional gene information for RRP36 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRP36 Gene

Genomics for RRP36 Gene

Regulatory Elements for RRP36 Gene

Enhancers for RRP36 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H043624 1.4 ENCODE dbSUPER 43.8 +606.4 606403 7.4 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D SSRP1 ZNF610 POLH GTPBP2 ZNF318 ABCC10 RRP36 RPS2P29 CUL7 XPO5 POLR1C ENSG00000271754
GH06H043266 2 FANTOM5 Ensembl ENCODE dbSUPER 25.6 +251.8 251817 13.1 FOXA2 MLX ARNT ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF143 PAF1 POLH ZNF318 GTPBP2 POLR1C RPS2P29 ABCC10 XPO5 CUL7 UBR2 RRP36
GH06H043765 1.4 ENCODE dbSUPER 31 +749.8 749767 11.5 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 MEF2D SSRP1 ZNF610 POLH ZNF318 GTPBP2 RPS2P29 RRP36 XPO5 POLR1C ENSG00000223469 RPS2P28 YIPF3
GH06H043810 1.5 Ensembl ENCODE dbSUPER 21.3 +791.0 790959 5.8 HDGF PKNOX1 ATF1 FOXA2 FEZF1 ZNF2 ZNF121 GLIS2 ZNF302 ZNF548 ZNF318 GTPBP2 POLH ABCC10 RPS2P29 RRP36 ENSG00000271970 RPL34P14 POLR1C PTK7
GH06H042928 1.4 ENCODE dbSUPER 22.4 -90.8 -90848 5.6 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A ZNF610 PEX6 ZNF318 POLH XPO5 RRP36 CUL7 GTPBP2 ABCC10 PPP2R5D RPS2P29
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RRP36 on UCSC Golden Path with GeneCards custom track

Promoters for RRP36 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for RRP36 Gene

Genomic Locations for RRP36 Gene
12,521 bases
Plus strand

Genomic View for RRP36 Gene

Genes around RRP36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRP36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRP36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRP36 Gene

Proteins for RRP36 Gene

  • Protein details for RRP36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribosomal RNA processing protein 36 homolog
    Protein Accession:
    Secondary Accessions:
    • Q9BRF6
    • Q9P0C8

    Protein attributes for RRP36 Gene

    259 amino acids
    Molecular mass:
    29823 Da
    Quaternary structure:
    No Data Available
    • Meningioma antigen.
    • Sequence=AAH06293.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RRP36 Gene


neXtProt entry for RRP36 Gene

Post-translational modifications for RRP36 Gene

  • Ubiquitination at Lys225
  • Modification sites at PhosphoSitePlus

Other Protein References for RRP36 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RRP36 Gene

Domains & Families for RRP36 Gene

Gene Families for RRP36 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RRP36 Gene


Suggested Antigen Peptide Sequences for RRP36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RRP36 family.
  • Belongs to the RRP36 family.
genes like me logo Genes that share domains with RRP36: view

Function for RRP36 Gene

Molecular function for RRP36 Gene

UniProtKB/Swiss-Prot Function:
Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA.

Phenotypes From GWAS Catalog for RRP36 Gene

Gene Ontology (GO) - Molecular Function for RRP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RRP36: view

Phenotypes for RRP36 Gene

GenomeRNAi human phenotypes for RRP36:
genes like me logo Genes that share phenotypes with RRP36: view

miRNA for RRP36 Gene

miRTarBase miRNAs that target RRP36

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRP36 Gene

Localization for RRP36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRP36 Gene

Nucleus, nucleolus. Note=Concentrated in the fibrillar region of the nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRP36 gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RRP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA,IDA 20038530
GO:0030686 90S preribosome IBA --
genes like me logo Genes that share ontologies with RRP36: view

Pathways & Interactions for RRP36 Gene

genes like me logo Genes that share pathways with RRP36: view

Gene Ontology (GO) - Biological Process for RRP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0000469 cleavage involved in rRNA processing IEA --
GO:0006364 rRNA processing TAS --
GO:0042254 ribosome biogenesis IEA --
GO:0042274 ribosomal small subunit biogenesis IDA 20038530
genes like me logo Genes that share ontologies with RRP36: view

No data available for SIGNOR curated interactions for RRP36 Gene

Drugs & Compounds for RRP36 Gene

No Compound Related Data Available

Transcripts for RRP36 Gene

mRNA/cDNA for RRP36 Gene

Unigene Clusters for RRP36 Gene

Ribosomal RNA processing 36 homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RRP36 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - - - -

Relevant External Links for RRP36 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RRP36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RRP36 Gene

Protein differential expression in normal tissues from HIPED for RRP36 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (32.9), Testis (7.6), CD8 Tcells (7.6), and Blymphocyte (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RRP36 Gene

Protein tissue co-expression partners for RRP36 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RRP36 Gene:


SOURCE GeneReport for Unigene cluster for RRP36 Gene:


Evidence on tissue expression from TISSUES for RRP36 Gene

  • Pancreas(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with RRP36: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RRP36 Gene

Orthologs for RRP36 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RRP36 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RRP36 33 34
  • 98.84 (n)
(Canis familiaris)
Mammalia RRP36 33
  • 89.8 (n)
(Bos Taurus)
Mammalia RRP36 33
  • 85.79 (n)
(Rattus norvegicus)
Mammalia Rrp36 33
  • 85.56 (n)
(Mus musculus)
Mammalia Rrp36 33 16 34
  • 83.41 (n)
(Monodelphis domestica)
Mammalia RRP36 34
  • 55 (a)
(Gallus gallus)
Aves LOC100858699 33
  • 59.82 (n)
RRP36 34
  • 52 (a)
(Anolis carolinensis)
Reptilia RRP36 34
  • 59 (a)
(Danio rerio)
Actinopterygii rrp36 33 34
  • 58.41 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3045 33
fruit fly
(Drosophila melanogaster)
Insecta CG8461 33 34
  • 49.53 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002333 33
  • 44.92 (n)
(Caenorhabditis elegans)
Secernentea T22H9.1 34
  • 14 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRP36 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G12650 33
  • 48.48 (n)
(Oryza sativa)
Liliopsida Os09g0525200 33
  • 47.12 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
Species where no ortholog for RRP36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RRP36 Gene

Gene Tree for RRP36 (if available)
Gene Tree for RRP36 (if available)

Paralogs for RRP36 Gene

No data available for Paralogs for RRP36 Gene

Variants for RRP36 Gene

Sequence variations from dbSNP and Humsavar for RRP36 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1001475564 -- 43,021,236(+) GCTGT(C/T)GCTGT nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1001623925 -- 43,026,646(+) CCAAC(C/T)TGGGC intron-variant
rs1001819790 -- 43,021,489(+) GACAA(C/T)GTCTC downstream-variant-500B, upstream-variant-2KB
rs1001918158 -- 43,025,408(+) CCTGA(C/G)ATCAG intron-variant
rs1002242809 -- 43,023,611(+) CGCTT(C/G)AACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RRP36 Gene

Variant ID Type Subtype PubMed ID
nsv602992 CNV loss 21841781
nsv462930 CNV loss 19166990
nsv462927 CNV loss 19166990
nsv1017398 CNV gain 25217958
dgv10640n54 CNV loss 21841781

Variation tolerance for RRP36 Gene

Residual Variation Intolerance Score: 69.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.48; 71.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRP36 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRP36 Gene

Disorders for RRP36 Gene

Relevant External Links for RRP36

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RRP36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRP36 Gene

Publications for RRP36 Gene

  1. Evolutionarily conserved function of RRP36 in early cleavages of the pre-rRNA and production of the 40S ribosomal subunit. (PMID: 20038530) Gérus M … Henras AK (Molecular and cellular biology 2010) 2 3 4 60
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  3. Complex humoral immune response against a benign tumor: frequent antibody response against specific antigens as diagnostic targets. (PMID: 15983380) Comtesse N … Meese E (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60

Products for RRP36 Gene

Sources for RRP36 Gene

Loading form....