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Aliases for RRP36 Gene

Aliases for RRP36 Gene

  • Ribosomal RNA Processing 36 2 3 5
  • C6orf153 3 4
  • Ribosomal RNA Processing 36 Homolog (S. Cerevisiae) 2
  • Chromosome 6 Open Reading Frame 153 2
  • Ribosomal RNA Processing 36 Homolog 3
  • RNA Processing Factor 3
  • DJ20C7.4 3

External Ids for RRP36 Gene

Previous HGNC Symbols for RRP36 Gene

  • C6orf153

Previous GeneCards Identifiers for RRP36 Gene

  • GC06P042993
  • GC06P042706
  • GC06P042995
  • GC06P043000
  • GC06P043002
  • GC06P043009

Summaries for RRP36 Gene

Entrez Gene Summary for RRP36 Gene

  • RRP36 functions at an early stage in the processing of 35S preribosomal RNA into the mature 18S species (Gerus et al., 2010 [PubMed 20038530]).[supplied by OMIM, Jul 2010]

GeneCards Summary for RRP36 Gene

RRP36 (Ribosomal RNA Processing 36) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for RRP36 Gene

  • Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRP36 Gene

Genomics for RRP36 Gene

Regulatory Elements for RRP36 Gene

Enhancers for RRP36 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RRP36 on UCSC Golden Path with GeneCards custom track

Promoters for RRP36 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RRP36 on UCSC Golden Path with GeneCards custom track

Genomic Location for RRP36 Gene

43,021,636 bp from pter
43,034,156 bp from pter
12,521 bases
Plus strand

Genomic View for RRP36 Gene

Genes around RRP36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRP36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRP36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRP36 Gene

Proteins for RRP36 Gene

  • Protein details for RRP36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribosomal RNA processing protein 36 homolog
    Protein Accession:
    Secondary Accessions:
    • Q9BRF6
    • Q9P0C8

    Protein attributes for RRP36 Gene

    259 amino acids
    Molecular mass:
    29823 Da
    Quaternary structure:
    No Data Available
    • Meningioma antigen.
    • Sequence=AAH06293.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RRP36 Gene


neXtProt entry for RRP36 Gene

Proteomics data for RRP36 Gene at MOPED

Post-translational modifications for RRP36 Gene

  • Ubiquitination at Lys 225
  • Modification sites at PhosphoSitePlus

Other Protein References for RRP36 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RRP36 Gene

Domains & Families for RRP36 Gene

Protein Domains for RRP36 Gene


Suggested Antigen Peptide Sequences for RRP36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RRP36 family.
  • Belongs to the RRP36 family.
genes like me logo Genes that share domains with RRP36: view

No data available for Gene Families for RRP36 Gene

Function for RRP36 Gene

Molecular function for RRP36 Gene

UniProtKB/Swiss-Prot Function:
Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA.

Phenotypes for RRP36 Gene

GenomeRNAi human phenotypes for RRP36:
genes like me logo Genes that share phenotypes with RRP36: view

Animal Model Products

CRISPR Products

miRNA for RRP36 Gene

miRTarBase miRNAs that target RRP36

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRP36 Gene

Localization for RRP36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRP36 Gene

Nucleus, nucleolus. Note=Concentrated in the fibrillar region of the nucleolus.

Subcellular locations from

Jensen Localization Image for RRP36 Gene COMPARTMENTS Subcellular localization image for RRP36 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for RRP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA 20038530
genes like me logo Genes that share ontologies with RRP36: view

Pathways & Interactions for RRP36 Gene

genes like me logo Genes that share pathways with RRP36: view

Pathways by source for RRP36 Gene

Interacting Proteins for RRP36 Gene

Gene Ontology (GO) - Biological Process for RRP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000469 cleavage involved in rRNA processing IEA --
genes like me logo Genes that share ontologies with RRP36: view

No data available for SIGNOR curated interactions for RRP36 Gene

Drugs & Compounds for RRP36 Gene

No Compound Related Data Available

Transcripts for RRP36 Gene

mRNA/cDNA for RRP36 Gene

Unigene Clusters for RRP36 Gene

Ribosomal RNA processing 36 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RRP36 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - - - -

Relevant External Links for RRP36 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RRP36 Gene

mRNA expression in normal human tissues for RRP36 Gene

Protein differential expression in normal tissues from HIPED for RRP36 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (32.9), Testis (7.6), CD8 Tcells (7.6), and Blymphocyte (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RRP36 Gene

SOURCE GeneReport for Unigene cluster for RRP36 Gene Hs.309231

genes like me logo Genes that share expression patterns with RRP36: view

Protein tissue co-expression partners for RRP36 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RRP36 Gene

Orthologs for RRP36 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RRP36 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RRP36 35
  • 85.79 (n)
  • 85.25 (a)
(Canis familiaris)
Mammalia RRP36 35
  • 89.8 (n)
  • 88.79 (a)
(Mus musculus)
Mammalia Rrp36 35
  • 83.41 (n)
  • 85.78 (a)
Rrp36 16
Rrp36 36
  • 84 (a)
(Pan troglodytes)
Mammalia RRP36 35
  • 98.84 (n)
  • 98.84 (a)
RRP36 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rrp36 35
  • 85.56 (n)
  • 88.02 (a)
(Monodelphis domestica)
Mammalia RRP36 36
  • 55 (a)
(Gallus gallus)
Aves LOC100858699 35
  • 59.82 (n)
  • 55.8 (a)
RRP36 36
  • 52 (a)
(Anolis carolinensis)
Reptilia RRP36 36
  • 59 (a)
(Danio rerio)
Actinopterygii rrp36 35
  • 58.41 (n)
  • 49.56 (a)
rrp36 36
  • 35 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3045 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002333 35
  • 44.92 (n)
  • 34.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8461 35
  • 49.53 (n)
  • 38.32 (a)
CG8461 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea T22H9.1 36
  • 14 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRP36 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G12650 35
  • 48.48 (n)
  • 43.03 (a)
(Oryza sativa)
Liliopsida Os09g0525200 35
  • 47.12 (n)
  • 37.02 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for RRP36:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RRP36 Gene

Gene Tree for RRP36 (if available)
Gene Tree for RRP36 (if available)

Paralogs for RRP36 Gene

No data available for Paralogs for RRP36 Gene

Variants for RRP36 Gene

Sequence variations from dbSNP and Humsavar for RRP36 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs3749903 - 43,025,087(-) TAGAA(C/G)CTTGT nc-transcript-variant, reference, missense
rs1138141 -- 43,027,473(+) CTGAA(A/G)AAATG nc-transcript-variant, reference, synonymous-codon
rs6458321 -- 43,024,074(+) gtctt(A/G)aactc intron-variant
rs6921535 -- 43,026,929(+) ggcgt(G/T)gtggc intron-variant
rs6929065 -- 43,022,664(+) gtctc(G/T)ctctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RRP36 Gene

Variant ID Type Subtype PubMed ID
nsv462927 CNV Loss 19166990
nsv462930 CNV Loss 19166990
nsv885839 CNV Loss 21882294

Variation tolerance for RRP36 Gene

Residual Variation Intolerance Score: 69.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.48; 71.70% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RRP36 Gene

Disorders for RRP36 Gene

Relevant External Links for RRP36

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RRP36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRP36 Gene

Publications for RRP36 Gene

  1. Evolutionarily conserved function of RRP36 in early cleavages of the pre-rRNA and production of the 40S ribosomal subunit. (PMID: 20038530) Gerus M. … Henras A.K. (Mol. Cell. Biol. 2010) 2 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for RRP36 Gene

Sources for RRP36 Gene