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Aliases for RRP1B Gene

Aliases for RRP1B Gene

  • Ribosomal RNA Processing 1B 2 3 5
  • KIAA0179 2 3 4
  • RRP1-Like Protein B 3 4
  • Ribosomal RNA Processing 1 Homolog B (S. Cerevisiae) 2
  • Protein Phosphatase 1, Regulatory Subunit 136 3
  • Ribosomal RNA Processing 1 Homolog B 3
  • Regulatory Subunit 136 2
  • Protein Phosphatase 1 2
  • PPP1R136 3
  • NNP1L 3
  • RRP1 3
  • NNP1 3

External Ids for RRP1B Gene

Previous HGNC Symbols for RRP1B Gene

  • KIAA0179

Previous GeneCards Identifiers for RRP1B Gene

  • GC21P043904
  • GC21P045079
  • GC21P030447

Summaries for RRP1B Gene

GeneCards Summary for RRP1B Gene

RRP1B (Ribosomal RNA Processing 1B) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is RRP1.

Gene Wiki entry for RRP1B Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRP1B Gene

Genomics for RRP1B Gene

Regulatory Elements for RRP1B Gene

Enhancers for RRP1B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RRP1B on UCSC Golden Path with GeneCards custom track

Promoters for RRP1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RRP1B on UCSC Golden Path with GeneCards custom track

Genomic Location for RRP1B Gene

43,659,548 bp from pter
43,696,079 bp from pter
36,532 bases
Plus strand

Genomic View for RRP1B Gene

Genes around RRP1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRP1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRP1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRP1B Gene

Proteins for RRP1B Gene

  • Protein details for RRP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribosomal RNA processing protein 1 homolog B
    Protein Accession:
    Secondary Accessions:
    • Q8TBZ4

    Protein attributes for RRP1B Gene

    758 amino acids
    Molecular mass:
    84428 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA11496.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RRP1B Gene


neXtProt entry for RRP1B Gene

Proteomics data for RRP1B Gene at MOPED

Post-translational modifications for RRP1B Gene

Other Protein References for RRP1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RRP1B Gene

Domains & Families for RRP1B Gene

Gene Families for RRP1B Gene

Protein Domains for RRP1B Gene


Suggested Antigen Peptide Sequences for RRP1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RRP1 family.
  • Belongs to the RRP1 family.
genes like me logo Genes that share domains with RRP1B: view

Function for RRP1B Gene

Phenotypes for RRP1B Gene

genes like me logo Genes that share phenotypes with RRP1B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRP1B Gene

Localization for RRP1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRP1B Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for RRP1B Gene COMPARTMENTS Subcellular localization image for RRP1B gene
Compartment Confidence
cytosol 5
nucleus 5
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RRP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000791 euchromatin IEA --
GO:0005829 cytosol IDA 16780588
GO:0030687 preribosome, large subunit precursor IBA --
genes like me logo Genes that share ontologies with RRP1B: view

Pathways & Interactions for RRP1B Gene

SuperPathways for RRP1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RRP1B Gene


No data available for Pathways by source and SIGNOR curated interactions for RRP1B Gene

Drugs & Compounds for RRP1B Gene

No Compound Related Data Available

Transcripts for RRP1B Gene

mRNA/cDNA for RRP1B Gene

Unigene Clusters for RRP1B Gene

Ribosomal RNA processing 1 homolog B (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RRP1B Gene

No ASD Table

Relevant External Links for RRP1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RRP1B Gene

mRNA expression in normal human tissues for RRP1B Gene

Protein differential expression in normal tissues from HIPED for RRP1B Gene

This gene is overexpressed in Lung (14.6), CD8 Tcells (11.3), Peripheral blood mononuclear cells (7.9), and NK cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RRP1B Gene

SOURCE GeneReport for Unigene cluster for RRP1B Gene Hs.565725

genes like me logo Genes that share expression patterns with RRP1B: view

Protein tissue co-expression partners for RRP1B Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RRP1B Gene

Orthologs for RRP1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RRP1B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RRP1B 35
  • 76.8 (n)
  • 69.61 (a)
RRP1B 36
  • 66 (a)
(Canis familiaris)
Mammalia RRP1B 35
  • 77.42 (n)
  • 70.77 (a)
RRP1B 36
  • 70 (a)
(Mus musculus)
Mammalia Rrp1b 35
  • 74.65 (n)
  • 65.32 (a)
Rrp1b 16
Rrp1b 36
  • 64 (a)
(Pan troglodytes)
Mammalia RRP1B 35
  • 99.38 (n)
  • 99.34 (a)
RRP1B 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rrp1b 35
  • 74.82 (n)
  • 66.53 (a)
(Monodelphis domestica)
Mammalia RRP1B 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia RRP1B 36
  • 52 (a)
(Gallus gallus)
Aves RRP1B 35
  • 59.26 (n)
  • 50.34 (a)
RRP1B 36
  • 45 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rrp1b 35
  • 57.66 (n)
  • 53.58 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53743 35
(Danio rerio)
Actinopterygii Dr.16314 35
rrp1 35
  • 52.09 (n)
  • 41.18 (a)
rrp1 36
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nnp-1 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea C47E12.7 36
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRP1 36
  • 28 (a)
RRP1 38
Species with no ortholog for RRP1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRP1B Gene

Gene Tree for RRP1B (if available)
Gene Tree for RRP1B (if available)

Paralogs for RRP1B Gene

Paralogs for RRP1B Gene

(1) SIMAP similar genes for RRP1B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RRP1B: view

Variants for RRP1B Gene

Sequence variations from dbSNP and Humsavar for RRP1B Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs2250773 -- 43,667,905(+) AACTA(C/T)CATAA intron-variant
rs2251253 -- 43,672,376(+) TCCTG(A/T)TGTTT intron-variant
rs2282527 -- 43,661,545(+) GATGA(A/C)ATAAA intron-variant
rs2298561 -- 43,665,353(+) AAGAT(A/G)CACAT intron-variant
rs2298562 -- 43,665,355(+) GATAC(A/G)CATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RRP1B Gene

Variant ID Type Subtype PubMed ID
nsv913873 CNV Loss 21882294
nsv834106 CNV Loss 17160897
nsv913874 CNV Loss 21882294
esv999311 CNV Deletion 20482838
esv2723614 CNV Deletion 23290073
esv2723615 CNV Deletion 23290073

Variation tolerance for RRP1B Gene

Residual Variation Intolerance Score: 53.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRP1B Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRP1B Gene

Disorders for RRP1B Gene

Relevant External Links for RRP1B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RRP1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRP1B Gene

Publications for RRP1B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Rrp1B gene polymorphism (1307T>C) in metastatic progression of breast cancer. (PMID: 25277657) Nanchari S.R. … Satti V. (Tumour Biol. 2015) 3
  3. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  4. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for RRP1B Gene

Sources for RRP1B Gene