RRP1B Gene
protein-coding GIFtS: 50
GCID: GC21P045079
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ribosomal RNA processing 1 homolog B (S. cerevisiae)(Previous name: KIAA0179 )
(Previous symbol: KIAA0179)
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Aliases
for RRP1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ribosomal RNA Processing 1 Homolog B (S. Cerevisiae)1 2 | | RRP1-Like Protein B2 3 | | KIAA01791 2 3 | | NNP1L2 | | Nnp11 2 | | Ribosomal RNA Processing Protein 1 Homolog B2 | | RRP11 2 | | |
Export aliases for RRP1B gene to outside databasesPrevious GC identifers: GC21P043904 GC21P030447 |
Summaries
for RRP1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for RRP1B
|
Genomic Views
for RRP1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000021.8 NC_018932.1 NT_011515.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RRP1B gene promoter:
c-Fos AP-1 Brachyury Bach2 AP-4 Nkx5-1 HEN1 c-Jun ATF Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for RRP1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RRP1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.3 HGNC cytogenetic band: 21q22.3RRP1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 21 GeneLoc Exon Structure GeneLoc location for GC21P045079: view genomic region
(about GC identifiers)
Start:
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45,079,429 bp from pter |
End:
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45,115,960 bp from pter |
Size:
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36,532 bases |
Orientation:
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plus strand |
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Proteins
for RRP1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RRP1B_HUMAN, Q14684 (See
protein sequence)Recommended Name: Ribosomal RNA processing protein 1 homolog B Size: 758 amino acids; 84428 Da
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=BAA11496.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q8TBZ4Alternative splicing: 2 isoforms: Q14684-1 Q14684-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RRP1B: NX_Q14684
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14684
RRP1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055871.1
ENSEMBL proteins: ENSP00000339145
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
RRP1B for ontologies About GeneDecksing
RRP1B Antibody Products:
Assay Products for RRP1B: |
Protein
Domains /
Families
for RRP1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RRP1B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q14684ProtoNet protein and cluster: Q14684 1 Blocks protein family: IPB010301 Nucleolar
UniProtKB/Swiss-Prot: RRP1B_HUMAN, Q14684Similarity: Belongs to the RRP1 family |
Function
for RRP1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RRP1B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RRP1B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRP1B |
1 GenomeRNAi human phenotype for RRP1B:
|
Pathways & Interactions
for RRP1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RRP1B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/49 Interacting proteins for RRP1B (Q146841, 3 ENSP000003391454) via UniProtKB, MINT, STRING, and/or I2D (see all 49)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
RRP1B for ontologies About GeneDecksing
|
Drugs & Compounds
for RRP1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RRP1B
Search CenterWatch for drugs/clinical trials and news about RRP1B
|
Transcripts
for RRP1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RRP1B gene: NM_015056.2 Unigene Cluster for RRP1B: Ribosomal RNA processing 1 homolog B (S. cerevisiae) Hs.565725 [show with all ESTs]Unigene Representative Sequence: NM_0150562 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000340648(uc002zdk.3) ENST00000470886(uc002zdl.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RRP1B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RRP1B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RRP1B (NM_015056) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RRP1B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRP1B |
Additional cDNA sequence: AK056263.1 BC014005.2 BC028386.2 D80001.1 16 DOTS entries: DT.100787145 DT.441385 DT.450248 DT.101980843 DT.99939879 DT.114909 DT.95169126 DT.97760082 DT.97846476 DT.100761039 DT.100041826 DT.40113192 DT.86842257 DT.91922594 DT.95102933 DT.95142154 24/169 AceView cDNA sequences (see all 169): CD653125 BE732744 BX374154 AW051907 AI275557 BM703697 AU119299 AW150763 CR605276 AK124620 BX479134 BE221756 BM715959 AA740730 CR601179 AI472169 AL043347 AK056263 BM451176 AI199682 BQ428241 AA425659 BG622897 BQ216155
GeneLoc Exon Structure
|
Expression
for RRP1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RRP1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RRP1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RRP1B
SOURCE GeneReport for Unigene cluster: Hs.565725
SABiosciences Custom PCR Arrays for RRP1B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RRP1B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RRP1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RRP1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RRP1B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRP1B |
Orthologs
for RRP1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RRP1B gene from 8/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RRP1B1 |
ribosomal RNA processing 1 homolog B (S. cerevisiae) |
58.7(n)
49.86(a) |
|
425237 NM_001031334.1 NP_001026505.1 |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
43(a) |
1 → many |
3(136737134-136765576) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC537432 |
hypothetical protein MGC53743 |
71.43(n) |
|
BC047979.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.163142 |
Danio rerio, Similar to DNA segment on chromosome 21 more |
77.14(n) |
|
BC045402.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Nnp-16 |
Nnp-1 |
17(a) |
1 → many |
2L(13363300-13366188) |
worm
(Caenorhabditis elegans) |
Secernentea |
C47E12.71 |
Protein C47E12.7 |
41.18(n)
27.42(a) |
|
177853 NM_069397.4 NP_501798.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G206001 |
hypothetical protein |
42.32(n)
30.43(a) |
|
832182 NM_122067.4 NP_197560.2 |
rice
(Oryza sativa) |
Liliopsida |
Os04g06586001 |
hypothetical protein |
42.46(n)
30.75(a) |
|
4337268 NM_001060664.1 NP_001054129.1 |
ENSEMBL Gene Tree for RRP1B (if available)
TreeFam Gene Tree for RRP1B (if available) |
Paralogs
for RRP1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RRP1B gene
- RRP12
1 SIMAP similar gene for RRP1B using alignment to 2 protein entries: RRP1B_HUMAN (see all proteins):RRP1
RRP1B for paralogs About GeneDecksing
|
Genomic Variants
for RRP1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 21 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RRP1B (45079429 - 45115960 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RRP1B: --
Human Gene Mutation Database (HGMD): RRP1B
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RRP1B |
|
Disorders
/ Diseases
for RRP1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RRP1B for disorders About GeneDecksing
OMIM gene information: 610654
OMIM disorders: --
3  diseases for RRP1B: About MalaCardscancer progression/metastasis metastasis efficiency breast cancer
Human Genome Epidemiology (HuGE) Navigator: RRP1B (3 documents)
Export disorders for RRP1B gene to outside databases
|
Publications
for RRP1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RRP1B gene, integrated from 9 sources (see all 43):
(articles sorted by number of sources associating them with RRP1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
- Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849)1, 2 Nagase T.... Nomura N. (1996)
- Gene expression profiling and qRT-PCR expression of RR P1B, PCNT, KIF21A and ADRB2 in leucocytes of Down's syndrome subjects. (PubMed id 22552340)1 Salemi M....Bosco P. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)1 Zhao J....Yang P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for RRP1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RRP1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RRP1B gene
(According to HUGE)
About This Section
| |
Specialized Databases showing RRP1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RRP1B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RRP1B gene:
Search GeneIP for patents involving RRP1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RRP1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | Browse OriGene 29mer shRNA kits in GFP-retroviral vector | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RRP1B | | | OriGene Protein Over-expression Lysate for RRP1B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RRP1B | | OriGene 3'-UTR Clone for RRP1B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RRP1B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RRP1B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RRP1B | | OriGene Custom Protein Services for RRP1B | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RRP1B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RRP1B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RRP1B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RRP1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RRP1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RRP1B |
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 | | | RRP1B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRP1B |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRP1B |
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