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Aliases for RRP1B Gene

Aliases for RRP1B Gene

  • Ribosomal RNA Processing 1B 2 3 5
  • KIAA0179 2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 136 2 3
  • RRP1-Like Protein B 3 4
  • Ribosomal RNA Processing 1 Homolog B (S. Cerevisiae) 2
  • Ribosomal RNA Processing Protein 1 Homolog B 3
  • Ribosomal RNA Processing 1 Homolog B 3
  • PPP1R136 3
  • NNP1L 3
  • RRP1 3
  • NNP1 3

External Ids for RRP1B Gene

Previous HGNC Symbols for RRP1B Gene

  • KIAA0179

Previous GeneCards Identifiers for RRP1B Gene

  • GC21P043904
  • GC21P045079
  • GC21P030447

Summaries for RRP1B Gene

GeneCards Summary for RRP1B Gene

RRP1B (Ribosomal RNA Processing 1B) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is RRP1.

Gene Wiki entry for RRP1B Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRP1B Gene

Genomics for RRP1B Gene

Regulatory Elements for RRP1B Gene

Enhancers for RRP1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RRP1B on UCSC Golden Path with GeneCards custom track

Promoters for RRP1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RRP1B Gene

43,659,548 bp from pter
43,696,079 bp from pter
36,532 bases
Plus strand

Genomic View for RRP1B Gene

Genes around RRP1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRP1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRP1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRP1B Gene

Proteins for RRP1B Gene

  • Protein details for RRP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribosomal RNA processing protein 1 homolog B
    Protein Accession:
    Secondary Accessions:
    • Q8TBZ4

    Protein attributes for RRP1B Gene

    758 amino acids
    Molecular mass:
    84428 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA11496.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RRP1B Gene


neXtProt entry for RRP1B Gene

Post-translational modifications for RRP1B Gene

Other Protein References for RRP1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RRP1B Gene

Domains & Families for RRP1B Gene

Gene Families for RRP1B Gene

Protein Domains for RRP1B Gene


Suggested Antigen Peptide Sequences for RRP1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RRP1 family.
  • Belongs to the RRP1 family.
genes like me logo Genes that share domains with RRP1B: view

Function for RRP1B Gene

Gene Ontology (GO) - Molecular Function for RRP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RRP1B: view

Phenotypes for RRP1B Gene

genes like me logo Genes that share phenotypes with RRP1B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRP1B Gene

Localization for RRP1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRP1B Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for RRP1B Gene COMPARTMENTS Subcellular localization image for RRP1B gene
Compartment Confidence
cytosol 5
nucleus 5
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RRP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000791 euchromatin IEA --
GO:0000792 heterochromatin IEA --
GO:0005634 nucleus IEA,IDA 16780588
GO:0005730 nucleolus IDA --
GO:0005829 cytosol IDA 16780588
genes like me logo Genes that share ontologies with RRP1B: view

Pathways & Interactions for RRP1B Gene

SuperPathways for RRP1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RRP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IBA --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with RRP1B: view

No data available for Pathways by source and SIGNOR curated interactions for RRP1B Gene

Drugs & Compounds for RRP1B Gene

No Compound Related Data Available

Transcripts for RRP1B Gene

mRNA/cDNA for RRP1B Gene

Unigene Clusters for RRP1B Gene

Ribosomal RNA processing 1 homolog B (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RRP1B Gene

No ASD Table

Relevant External Links for RRP1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RRP1B Gene

mRNA expression in normal human tissues for RRP1B Gene

Protein differential expression in normal tissues from HIPED for RRP1B Gene

This gene is overexpressed in Lung (14.6), CD8 Tcells (11.3), Peripheral blood mononuclear cells (7.9), and NK cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RRP1B Gene

Protein tissue co-expression partners for RRP1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RRP1B Gene:


SOURCE GeneReport for Unigene cluster for RRP1B Gene:

genes like me logo Genes that share expression patterns with RRP1B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RRP1B Gene

Orthologs for RRP1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RRP1B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RRP1B 34
  • 76.8 (n)
  • 69.61 (a)
RRP1B 35
  • 66 (a)
(Canis familiaris)
Mammalia RRP1B 34
  • 77.42 (n)
  • 70.77 (a)
RRP1B 35
  • 70 (a)
(Mus musculus)
Mammalia Rrp1b 34
  • 74.65 (n)
  • 65.32 (a)
Rrp1b 16
Rrp1b 35
  • 64 (a)
(Pan troglodytes)
Mammalia RRP1B 34
  • 99.38 (n)
  • 99.34 (a)
RRP1B 35
  • 99 (a)
(Rattus norvegicus)
Mammalia Rrp1b 34
  • 74.82 (n)
  • 66.53 (a)
(Monodelphis domestica)
Mammalia RRP1B 35
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia RRP1B 35
  • 52 (a)
(Gallus gallus)
Aves RRP1B 34
  • 59.26 (n)
  • 50.34 (a)
RRP1B 35
  • 45 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rrp1b 34
  • 57.66 (n)
  • 53.58 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53743 34
(Danio rerio)
Actinopterygii Dr.16314 34
rrp1 34
  • 52.09 (n)
  • 41.18 (a)
rrp1 35
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nnp-1 35
  • 19 (a)
(Caenorhabditis elegans)
Secernentea C47E12.7 35
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRP1 35
  • 28 (a)
RRP1 37
Species where no ortholog for RRP1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRP1B Gene

Gene Tree for RRP1B (if available)
Gene Tree for RRP1B (if available)

Paralogs for RRP1B Gene

Paralogs for RRP1B Gene

(1) SIMAP similar genes for RRP1B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RRP1B: view

Variants for RRP1B Gene

Sequence variations from dbSNP and Humsavar for RRP1B Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs2155722 -- 43,676,325(+) GCTGC(A/G)AAGAC reference, synonymous-codon
rs7277976 -- 43,664,131(+) GAAAA(C/T)AGATG intron-variant
rs9974513 -- 43,680,117(+) ggtat(A/G)tgatt intron-variant
rs9974851 -- 43,693,743(+) AACTG(C/G)ACTTC utr-variant-3-prime
rs7279214 -- 43,664,161(+) GGgcc(A/G)ggcgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RRP1B Gene

Variant ID Type Subtype PubMed ID
esv2723614 CNV deletion 23290073
esv2723615 CNV deletion 23290073
esv3647110 CNV gain 21293372
esv999311 CNV deletion 20482838
nsv1066728 CNV loss 25217958
nsv1123566 CNV deletion 24896259
nsv587700 CNV loss 21841781
nsv834106 CNV loss 17160897

Variation tolerance for RRP1B Gene

Residual Variation Intolerance Score: 53.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRP1B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRP1B Gene

Disorders for RRP1B Gene

Relevant External Links for RRP1B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RRP1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRP1B Gene

Publications for RRP1B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  2. Distinct inherited metastasis susceptibility exists for different breast cancer subtypes: a prognosis study. (PMID: 19825179) Hsieh S.M. … Hunter K.W. (Breast Cancer Res. 2009) 3 46 65
  3. Rrp1b, a new candidate susceptibility gene for breast cancer progression and metastasis. (PMID: 18081427) Crawford N.P. … Hunter K.W. (PLoS Genet. 2007) 3 46 65
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 65
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 65

Products for RRP1B Gene

Sources for RRP1B Gene

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