RRP15 Gene
protein-coding GIFtS: 44
GCID: GC01P218458
|
|
ribosomal RNA processing 15 homolog (S. cerevisiae)(Previous name: KIAA0507 )
(Previous symbol: KIAA0507)
| |
Aliases
for RRP15 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ribosomal RNA Processing 15 Homolog (S. Cerevisiae)1 2 | | KIAA05071 2 3 | | Ribosomal RNA-Processing Protein 152 3 | | CGI-1151 | | RRP15-Like Protein2 |
Export aliases for RRP15 gene to outside databasesPrevious GC identifers: GC01P216526 GC01P189126 |
Summaries
for RRP15 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RRP15:
This gene encodes a protein that co-purifies with human nucleoli. A similar protein in budding yeast is a component ofpre-60S ribosomal particles, and is required for the early maturation steps of the 60S subunit. (provided by RefSeq,Jul 2008)
Gene Wiki entry for RRP15
|
Genomic Views
for RRP15 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RRP15 gene promoter:
Max1 RFX1 Pax-5 Bach2 Meis-1b Evi-1 Meis-1a TGIF Meis-1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for RRP15
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RRP15 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q41 Ensembl cytogenetic band: 1q41 HGNC cytogenetic band: 1q41RRP15 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P218458: view genomic region
(about GC identifiers)
Start:
|
218,458,629 bp from pter |
End:
|
218,511,325 bp from pter |
Size:
|
52,697 bases |
Orientation:
|
plus strand |
|
Proteins
for RRP15 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RRP15_HUMAN, Q9Y3B9 (See
protein sequence)Recommended Name: RRP15-like protein Size: 282 amino acids; 31484 Da
Sequence caution: Sequence=AAD34110.1; Type=Erroneous initiation; Sequence=AAH20641.1; Type=Erroneous initiation;Explore the universe of human proteins at neXtProt for RRP15: NX_Q9Y3B9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y3B9
RRP15 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057136.2
ENSEMBL proteins: ENSP00000355899
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RRP15 for ontologies About GeneDecksing
RRP15 Antibody Products:
Assay Products for RRP15: |
Protein
Domains /
Families
for RRP15 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RRP15 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y3B9ProtoNet protein and cluster: Q9Y3B9 1 Blocks protein family: IPB012459 Protein of unknown function DUF1665
UniProtKB/Swiss-Prot: RRP15_HUMAN, Q9Y3B9Similarity: Belongs to the RRP15 family |
Function
for RRP15 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RRP15 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RRP15 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RRP15 (NM_016052) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RRP15 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRP15 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRP15 |
|
Pathways & Interactions
for RRP15 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RRP15
STRING Interaction
Network Preview (showing 5 interactants - click image to see 18)
5/18 Interacting proteins for RRP15 (Q9Y3B91, 3 ENSP000003558994) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
|
Drugs & Compounds
for RRP15 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RRP15
Search CenterWatch for drugs/clinical trials and news about RRP15
|
Transcripts
for RRP15 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RRP15 gene: NM_016052.3 Unigene Cluster for RRP15: Ribosomal RNA processing 15 homolog (S. cerevisiae) Hs.660109 [show with all ESTs]Unigene Representative Sequence: NM_0160522 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000366932(uc001hlj.3) ENST00000491428
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RRP15 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RRP15 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RRP15 (NM_016052) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RRP15 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRP15 |
Additional cDNA sequence: AB007976.1 AF151873.1 AK290066.1 BC003668.1 BC020641.1 5 DOTS entries: DT.412230 DT.40268663 DT.121430595 DT.95254493 DT.95254494 24/93 AceView cDNA sequences (see all 93): CA431109 BC020641 CA412246 CR597182 NM_016052 AW663718 AA541261 AA305553 CB145763 CR591830 AI261610 AA813622 AA936567 AW339882 BU683445 BF061689 AA677453 BE876695 CR622638 AI123534 AA479913 AI824785 BU678079 BM845690
GeneLoc Exon Structure
|
Expression
for RRP15 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RRP15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTCCACTGT
About this image
See RRP15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RRP15
SOURCE GeneReport for Unigene cluster: Hs.660109
SABiosciences Custom PCR Arrays for RRP15
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RRP15
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RRP15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RRP15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RRP15 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRP15 |
Orthologs
for RRP15 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RRP15 gene from 9/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Rrp151 , 5 |
ribosomal RNA processing 15 homolog (S. cerevisiae)1, 5 |
77.82(n)1
76(a)1 |
|
1 (89.95 cM)5
672231 NM_026041.21 NP_080317.31
1867209785 |
chicken
(Gallus gallus) |
Aves |
RRP151 |
ribosomal RNA processing 15 homolog (S. cerevisiae) |
71.09(n)
65.49(a) |
|
421353 XM_419413.2 XP_419413.1 |
lizard
(Anolis carolinensis) |
Reptilia |
RRP156 |
-- |
64(a) |
1 ↔ 1 |
1(242433942-242465101) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.186222 |
Xenopus laevis transcribed sequence with weak similarity more |
79.36(n) |
|
BX844826.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufa20e102 |
wufa20e10 |
75.37(n) |
|
327053 BC046037.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG38171 |
CG3817 |
45.85(n)
34.27(a) |
|
41805 NM_142148.3 NP_650405.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
F53E10.66 |
RRP15-like protein |
27(a) |
1 ↔ 1 |
V(2601690-2603063) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G482406 |
uncharacterized protein |
17(a) |
1 ↔ 1 |
5(19559243-19561275) |
rice
(Oryza sativa) |
Liliopsida |
-- |
transposon protein, putative, unclassified, expres... |
20(a) |
1 ↔ 1 |
11(9108378-9113049) |
ENSEMBL Gene Tree for RRP15 (if available)
TreeFam Gene Tree for RRP15 (if available) |
Paralogs
for RRP15 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RRP15 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RRP15 (218458629 - 218511325 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RRP15: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RRP15 |
|
Disorders
/ Diseases
for RRP15 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 RRP15 for disorders About MalaCards
RRP15 for disorders About GeneDecksing
OMIM gene information: 611193
OMIM disorders: --
Export disorders for RRP15 gene to outside databases
|
Publications
for RRP15 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RRP15 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with RRP15) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Rrp15p, a novel component of pre-ribosomal particles required for 60S ribosome subunit maturation. (PubMed id 15769876)1, 3 De Marchis M.L....Fatica A. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
|
External Searches for RRP15 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RRP15 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RRP15 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing RRP15 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RRP15 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RRP15 gene:
Search GeneIP for patents involving RRP15
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RRP15 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RRP15 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RRP15 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RRP15 | | | OriGene Protein Over-expression Lysate for RRP15 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RRP15 | | OriGene 3'-UTR Clone for RRP15 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RRP15 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RRP15 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RRP15 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RRP15 | | OriGene Custom Protein Services for RRP15 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RRP15 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RRP15 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RRP15 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RRP15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RRP15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RRP15 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for RRP15 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | RRP15 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRP15 |
|  |  |  | | | | Search ThermoFisher Antibodies for RRP15 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRP15 |
|
|
|
|
