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Aliases for RRP15 Gene

Aliases for RRP15 Gene

  • Ribosomal RNA Processing 15 Homolog 2 3 5
  • KIAA0507 2 3 4
  • Ribosomal RNA-Processing Protein 15 3 4
  • Ribosomal RNA Processing 15 Homolog (S. Cerevisiae) 2
  • RRP15-Like Protein 3
  • CGI-115 3

External Ids for RRP15 Gene

Previous HGNC Symbols for RRP15 Gene

  • KIAA0507

Previous GeneCards Identifiers for RRP15 Gene

  • GC01P216526
  • GC01P218458
  • GC01P189126

Summaries for RRP15 Gene

Entrez Gene Summary for RRP15 Gene

  • This gene encodes a protein that co-purifies with human nucleoli. A similar protein in budding yeast is a component of pre-60S ribosomal particles, and is required for the early maturation steps of the 60S subunit. [provided by RefSeq, Jul 2008]

GeneCards Summary for RRP15 Gene

RRP15 (Ribosomal RNA Processing 15 Homolog) is a Protein Coding gene.

Gene Wiki entry for RRP15 Gene

Additional gene information for RRP15 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRP15 Gene

Genomics for RRP15 Gene

Regulatory Elements for RRP15 Gene

Enhancers for RRP15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H218284 1.2 ENCODE 54 +0.3 259 2.2 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 RRP15 ENSG00000223842 RIMKLBP2 GC01M218293
GH01H218344 2.6 FANTOM5 ENCODE dbSUPER 20.6 +64.2 64176 9.9 PKNOX1 ATF1 SIN3A FEZF1 GLI4 ZNF2 TCF12 GLIS2 GATA2 ATF7 RRP15 TGFB2-AS1 GC01M218380
GH01H218373 1.8 FANTOM5 Ensembl ENCODE dbSUPER 17.1 +90.6 90569 4.6 FOXA2 SIN3A FEZF1 BRCA1 GLIS2 FOS RUNX3 SP3 JUNB TSHZ1 RRP15 TGFB2-AS1 TGFB2 C1orf143 GC01M218380
GH01H218369 1.2 Ensembl ENCODE dbSUPER 18.5 +85.9 85947 3.9 SOX13 CEBPG NR2F6 MAFK SOX5 GATAD2A TEAD1 HLF MXD4 CEBPB RRP15 TGFB2-AS1 TGFB2 C1orf143 GC01M218380
GH01H219173 1.4 Ensembl ENCODE 12.6 +889.6 889642 3.6 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 RRP15 LYPLAL1-AS1 GC01M219200
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RRP15 on UCSC Golden Path with GeneCards custom track

Promoters for RRP15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for RRP15 Gene

Genomic Locations for RRP15 Gene
52,699 bases
Plus strand

Genomic View for RRP15 Gene

Genes around RRP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRP15 Gene

Proteins for RRP15 Gene

  • Protein details for RRP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RRP15-like protein
    Protein Accession:

    Protein attributes for RRP15 Gene

    282 amino acids
    Molecular mass:
    31484 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD34110.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH20641.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RRP15 Gene

Post-translational modifications for RRP15 Gene

Other Protein References for RRP15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RRP15 Gene

Domains & Families for RRP15 Gene

Gene Families for RRP15 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RRP15 Gene

Suggested Antigen Peptide Sequences for RRP15 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RRP15 family.
  • Belongs to the RRP15 family.
genes like me logo Genes that share domains with RRP15: view

Function for RRP15 Gene

Phenotypes From GWAS Catalog for RRP15 Gene

genes like me logo Genes that share phenotypes with RRP15: view

miRNA for RRP15 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRP15 Gene

Localization for RRP15 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRP15 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytoskeleton 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RRP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030687 preribosome, large subunit precursor IBA --
genes like me logo Genes that share ontologies with RRP15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RRP15 Gene

Pathways & Interactions for RRP15 Gene

SuperPathways for RRP15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RRP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000460 maturation of 5.8S rRNA IBA --
GO:0000470 maturation of LSU-rRNA IBA --
GO:0006364 rRNA processing IEA --
genes like me logo Genes that share ontologies with RRP15: view

No data available for Pathways by source and SIGNOR curated interactions for RRP15 Gene

Drugs & Compounds for RRP15 Gene

No Compound Related Data Available

Transcripts for RRP15 Gene

mRNA/cDNA for RRP15 Gene

Unigene Clusters for RRP15 Gene

Ribosomal RNA processing 15 homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RRP15 Gene

No ASD Table

Relevant External Links for RRP15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RRP15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RRP15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RRP15 Gene

This gene is overexpressed in Lung (34.8) and Adrenal (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RRP15 Gene

Protein tissue co-expression partners for RRP15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RRP15 Gene:


SOURCE GeneReport for Unigene cluster for RRP15 Gene:


Evidence on tissue expression from TISSUES for RRP15 Gene

  • Skin(2)
genes like me logo Genes that share expression patterns with RRP15: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RRP15 Gene

Orthologs for RRP15 Gene

This gene was present in the common ancestor of animals.

Orthologs for RRP15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RRP15 33 34
  • 99.29 (n)
(Canis familiaris)
Mammalia RRP15 33 34
  • 83.51 (n)
(Bos Taurus)
Mammalia RRP15 33 34
  • 82.51 (n)
-- 34
  • 68 (a)
(Mus musculus)
Mammalia Rrp15 33 16 34
  • 77.45 (n)
(Rattus norvegicus)
Mammalia Rrp15 33
  • 76.24 (n)
(Monodelphis domestica)
Mammalia RRP15 34
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia RRP15 34
  • 59 (a)
(Gallus gallus)
Aves RRP15 33 34
  • 70.93 (n)
(Anolis carolinensis)
Reptilia RRP15 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rrp15 33
  • 66 (n)
Str.6662 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.18622 33
(Danio rerio)
Actinopterygii rrp15 33 34
  • 63.78 (n)
wufa20e10 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13265 33
fruit fly
(Drosophila melanogaster)
Insecta CG3817 34
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
Species where no ortholog for RRP15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RRP15 Gene

Gene Tree for RRP15 (if available)
Gene Tree for RRP15 (if available)

Paralogs for RRP15 Gene

No data available for Paralogs for RRP15 Gene

Variants for RRP15 Gene

Sequence variations from dbSNP and Humsavar for RRP15 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000084257 -- 218,334,567(+) TGTCA(A/T)TACTT utr-variant-3-prime
rs1000119690 -- 218,314,450(+) TTCTT(A/G)GAATG intron-variant
rs1000172028 -- 218,318,304(+) ATAAC(-/T)TTTTG intron-variant
rs1000174107 -- 218,314,132(+) TTACA(G/T)GCATG intron-variant
rs1000212412 -- 218,294,503(+) TTATT(A/G)TAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RRP15 Gene

Variant ID Type Subtype PubMed ID
nsv4598 CNV deletion 18451855
nsv1005829 CNV gain 25217958
esv3588869 CNV gain 21293372

Variation tolerance for RRP15 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.77; 66.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRP15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRP15 Gene

Disorders for RRP15 Gene

Relevant External Links for RRP15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RRP15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRP15 Gene

Publications for RRP15 Gene

  1. Rrp15p, a novel component of pre-ribosomal particles required for 60S ribosome subunit maturation. (PMID: 15769876) De Marchis ML … Fatica A (RNA (New York, N.Y.) 2005) 2 3 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60

Products for RRP15 Gene

Sources for RRP15 Gene

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