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Aliases for RRP12 Gene

Aliases for RRP12 Gene

  • Ribosomal RNA Processing 12 Homolog 2 3 5
  • KIAA0690 2 3 4
  • Ribosomal RNA Processing 12 Homolog (S. Cerevisiae) 2
  • RRP12-Like Protein 3

External Ids for RRP12 Gene

Previous HGNC Symbols for RRP12 Gene

  • KIAA0690

Previous GeneCards Identifiers for RRP12 Gene

  • GC10M099107
  • GC10M092741

Summaries for RRP12 Gene

GeneCards Summary for RRP12 Gene

RRP12 (Ribosomal RNA Processing 12 Homolog) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and binding.

Gene Wiki entry for RRP12 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRP12 Gene

Genomics for RRP12 Gene

Regulatory Elements for RRP12 Gene

Enhancers for RRP12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F097405 1.6 FANTOM5 Ensembl ENCODE 38.2 +18.7 18689 4.0 HDGF ATF1 MLX ZFP64 ARID4B ZNF48 ZNF2 ZNF143 ZNF263 MXD4 FRAT2 RRP12 FRAT1 ARHGAP19 ZDHHC16 EXOSC1 MMS19 UBTD1 ENSG00000249967 HOGA1
GH10F097399 1 ENCODE 39.6 +25.2 25200 2.5 ATF1 CREB3L1 ARID4B SIN3A DMAP1 BRCA1 ZNF2 ETS1 ZNF121 ELK1 RRP12 ENSG00000200737 PGAM1 MMS19 UBTD1 ARHGAP19 ENSG00000231970 RPL34P20
GH10F097412 1.5 FANTOM5 Ensembl ENCODE 22.2 +12.1 12058 3.2 ELF3 TBP ATF1 CBX3 NFRKB RAD21 ZNF121 ELK1 GATA2 FOS RRP12 EXOSC1 ZDHHC16 MMS19 UBTD1 PGAM1 LCOR ZFYVE27 ARHGAP19 FRAT1
GH10F097355 0.9 Ensembl ENCODE 34.1 +69.8 69808 2.1 SRF CTCF ZNF654 E2F5 USF2 MAX REST RAD21 RAD51 SMC3 RRP12 ARHGAP19 SLIT1 SLIT1-AS1 ENSG00000249967 HOGA1 C10orf62 PI4K2A PGAM1 FRAT2
GH10F097379 0.8 ENCODE 37.7 +45.2 45241 2.5 PKNOX1 JUN KLF17 ZIC2 CTBP1 GATA3 ZFHX2 FOXK2 FOS ZNF600 RRP12 ARHGAP19 ENSG00000200737 PGAM1 RPL34P20 FRAT2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RRP12 on UCSC Golden Path with GeneCards custom track

Promoters for RRP12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000359990 -724 3201 HDGF PKNOX1 WRNIP1 ZNF133 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF143

Genomic Location for RRP12 Gene

Chromosome:
10
Start:
97,356,358 bp from pter
End:
97,426,076 bp from pter
Size:
69,719 bases
Orientation:
Minus strand

Genomic View for RRP12 Gene

Genes around RRP12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRP12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRP12 Gene

Proteins for RRP12 Gene

  • Protein details for RRP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JTH9-RRP12_HUMAN
    Recommended name:
    RRP12-like protein
    Protein Accession:
    Q5JTH9
    Secondary Accessions:
    • B4DK00
    • E9PCK7
    • Q5JTH8
    • Q69YK4
    • Q96E87
    • Q9BUH3
    • Q9Y4C7

    Protein attributes for RRP12 Gene

    Size:
    1297 amino acids
    Molecular mass:
    143702 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA31665.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RRP12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RRP12 Gene

Post-translational modifications for RRP12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RRP12 Gene

Domains & Families for RRP12 Gene

Suggested Antigen Peptide Sequences for RRP12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JTH9

UniProtKB/Swiss-Prot:

RRP12_HUMAN :
  • Belongs to the RRP12 family.
Family:
  • Belongs to the RRP12 family.
genes like me logo Genes that share domains with RRP12: view

No data available for Gene Families for RRP12 Gene

Function for RRP12 Gene

Gene Ontology (GO) - Molecular Function for RRP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RRP12: view
genes like me logo Genes that share phenotypes with RRP12: view

Animal Model Products

miRNA for RRP12 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRP12 Gene

Localization for RRP12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRP12 Gene

Nucleus, nucleolus. Nucleus membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRP12 gene
Compartment Confidence
nucleus 5
mitochondrion 2
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for RRP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with RRP12: view

Pathways & Interactions for RRP12 Gene

SuperPathways for RRP12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RRP12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RRP12 Gene

Transcripts for RRP12 Gene

Unigene Clusters for RRP12 Gene

Ribosomal RNA processing 12 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RRP12 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17a · 17b ^
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6: - -
SP7:
SP8: -
SP9:

ExUns: 18 ^ 19 ^ 20a · 20b ^ 21a · 21b
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for RRP12 Gene

GeneLoc Exon Structure for
RRP12
ECgene alternative splicing isoforms for
RRP12

Expression for RRP12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RRP12 Gene

mRNA differential expression in normal tissues according to GTEx for RRP12 Gene

This gene is overexpressed in Whole Blood (x4.9) and Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for RRP12 Gene

This gene is overexpressed in Bone (11.8) and Peripheral blood mononuclear cells (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RRP12 Gene



Protein tissue co-expression partners for RRP12 Gene

NURSA nuclear receptor signaling pathways regulating expression of RRP12 Gene:

RRP12

SOURCE GeneReport for Unigene cluster for RRP12 Gene:

Hs.434251

mRNA Expression by UniProt/SwissProt for RRP12 Gene:

Q5JTH9-RRP12_HUMAN
Tissue specificity: Weakly expressed. Expressed at intermediate level in testis and ovary.
genes like me logo Genes that share expression patterns with RRP12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RRP12 Gene

Orthologs for RRP12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RRP12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RRP12 34 35
  • 99.2 (n)
dog
(Canis familiaris)
Mammalia RRP12 34 35
  • 89.17 (n)
cow
(Bos Taurus)
Mammalia RRP12 34 35
  • 87.72 (n)
mouse
(Mus musculus)
Mammalia Rrp12 34 16 35
  • 87.1 (n)
rat
(Rattus norvegicus)
Mammalia Rrp12 34
  • 86.89 (n)
oppossum
(Monodelphis domestica)
Mammalia RRP12 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RRP12 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves RRP12 34 35
  • 73.16 (n)
lizard
(Anolis carolinensis)
Reptilia RRP12 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rrp12 34
  • 66.56 (n)
zebrafish
(Danio rerio)
Actinopterygii rrp12 34 35
  • 63.98 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002961 34
  • 46.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2691 34 35
  • 46.05 (n)
worm
(Caenorhabditis elegans)
Secernentea Y46E12BL.2 34 35
  • 42.72 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL014C 34
  • 40.78 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F27269g 34
  • 40.15 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRP12 34 35 37
  • 38.92 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G34357 34
  • 40.66 (n)
rice
(Oryza sativa)
Liliopsida Os02g0782100 34
  • 41.31 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01675 34
  • 44.98 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToOne
Species where no ortholog for RRP12 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRP12 Gene

ENSEMBL:
Gene Tree for RRP12 (if available)
TreeFam:
Gene Tree for RRP12 (if available)

Paralogs for RRP12 Gene

No data available for Paralogs for RRP12 Gene

Variants for RRP12 Gene

Sequence variations from dbSNP and Humsavar for RRP12 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1048442 -- 97,400,395(-) TCGGG(C/T)ACCTT nc-transcript-variant, reference, synonymous-codon
rs1048445 -- 97,357,146(-) TGCCC(A/G)GCGAG reference, missense
rs10786336 -- 97,375,196(+) tcaag(A/C)aatcc intron-variant
rs10786337 -- 97,387,716(+) CGGGC(A/G)GATCA intron-variant
rs10786338 -- 97,391,351(+) CAGAT(A/T)ACCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RRP12 Gene

Variant ID Type Subtype PubMed ID
nsv948157 CNV duplication 23825009
nsv831952 CNV loss 17160897
nsv825535 CNV gain 20364138
nsv552025 CNV loss 21841781
nsv467440 CNV loss 19166990
nsv1110852 OTHER inversion 24896259
esv2739895 CNV deletion 23290073
esv2739884 CNV deletion 23290073
dgv1369n54 CNV loss 21841781
dgv119n27 CNV loss 19166990

Variation tolerance for RRP12 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.30; 98.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRP12 Gene

Human Gene Mutation Database (HGMD)
RRP12
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RRP12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRP12 Gene

Disorders for RRP12 Gene

Relevant External Links for RRP12

Genetic Association Database (GAD)
RRP12
Human Genome Epidemiology (HuGE) Navigator
RRP12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RRP12

No disorders were found for RRP12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRP12 Gene

Publications for RRP12 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for RRP12 Gene

Sources for RRP12 Gene

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