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Aliases for RRP12 Gene

Aliases for RRP12 Gene

  • Ribosomal RNA Processing 12 Homolog 2 3 5
  • KIAA0690 2 3 4
  • Ribosomal RNA Processing 12 Homolog (S. Cerevisiae) 2

External Ids for RRP12 Gene

Previous HGNC Symbols for RRP12 Gene

  • KIAA0690

Previous GeneCards Identifiers for RRP12 Gene

  • GC10M099107
  • GC10M092741

Summaries for RRP12 Gene

GeneCards Summary for RRP12 Gene

RRP12 (Ribosomal RNA Processing 12 Homolog) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and binding.

Gene Wiki entry for RRP12 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRP12 Gene

Genomics for RRP12 Gene

Regulatory Elements for RRP12 Gene

Enhancers for RRP12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RRP12 on UCSC Golden Path with GeneCards custom track

Genomic Location for RRP12 Gene

Chromosome:
10
Start:
97,356,358 bp from pter
End:
97,426,076 bp from pter
Size:
69,719 bases
Orientation:
Minus strand

Genomic View for RRP12 Gene

Genes around RRP12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRP12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRP12 Gene

Proteins for RRP12 Gene

  • Protein details for RRP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JTH9-RRP12_HUMAN
    Recommended name:
    RRP12-like protein
    Protein Accession:
    Q5JTH9
    Secondary Accessions:
    • B4DK00
    • E9PCK7
    • Q5JTH8
    • Q69YK4
    • Q96E87
    • Q9BUH3
    • Q9Y4C7

    Protein attributes for RRP12 Gene

    Size:
    1297 amino acids
    Molecular mass:
    143702 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA31665.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RRP12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RRP12 Gene

Proteomics data for RRP12 Gene at MOPED

Post-translational modifications for RRP12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RRP12 Gene

Domains & Families for RRP12 Gene

Protein Domains for RRP12 Gene

Suggested Antigen Peptide Sequences for RRP12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JTH9

UniProtKB/Swiss-Prot:

RRP12_HUMAN :
  • Belongs to the RRP12 family.
Family:
  • Belongs to the RRP12 family.
genes like me logo Genes that share domains with RRP12: view

No data available for Gene Families for RRP12 Gene

Function for RRP12 Gene

genes like me logo Genes that share phenotypes with RRP12: view

Animal Model Products

miRNA for RRP12 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRP12 Gene

Localization for RRP12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRP12 Gene

Nucleus, nucleolus. Nucleus membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RRP12 Gene COMPARTMENTS Subcellular localization image for RRP12 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RRP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with RRP12: view

Pathways & Interactions for RRP12 Gene

SuperPathways for RRP12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RRP12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RRP12 Gene

Drugs & Compounds for RRP12 Gene

No Compound Related Data Available

Transcripts for RRP12 Gene

Unigene Clusters for RRP12 Gene

Ribosomal RNA processing 12 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RRP12 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17a · 17b ^
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6: - -
SP7:
SP8: -
SP9:

ExUns: 18 ^ 19 ^ 20a · 20b ^ 21a · 21b
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for RRP12 Gene

GeneLoc Exon Structure for
RRP12
ECgene alternative splicing isoforms for
RRP12

Expression for RRP12 Gene

mRNA expression in normal human tissues for RRP12 Gene

mRNA differential expression in normal tissues according to GTEx for RRP12 Gene

This gene is overexpressed in Whole Blood (x4.9) and Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for RRP12 Gene

This gene is overexpressed in Bone (11.8) and Peripheral blood mononuclear cells (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RRP12 Gene



SOURCE GeneReport for Unigene cluster for RRP12 Gene Hs.434251

mRNA Expression by UniProt/SwissProt for RRP12 Gene

Q5JTH9-RRP12_HUMAN
Tissue specificity: Weakly expressed. Expressed at intermediate level in testis and ovary.
genes like me logo Genes that share expression patterns with RRP12: view

Protein tissue co-expression partners for RRP12 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RRP12 Gene

Orthologs for RRP12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RRP12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RRP12 35
  • 87.72 (n)
  • 90.32 (a)
RRP12 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RRP12 35
  • 89.17 (n)
  • 92.05 (a)
RRP12 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rrp12 35
  • 87.1 (n)
  • 90.48 (a)
Rrp12 16
Rrp12 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RRP12 35
  • 99.2 (n)
  • 99.23 (a)
RRP12 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rrp12 35
  • 86.89 (n)
  • 89.71 (a)
oppossum
(Monodelphis domestica)
Mammalia RRP12 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RRP12 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves RRP12 35
  • 73.16 (n)
  • 71.37 (a)
RRP12 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RRP12 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rrp12 35
  • 66.56 (n)
  • 68.85 (a)
zebrafish
(Danio rerio)
Actinopterygii rrp12 35
  • 63.98 (n)
  • 62.33 (a)
rrp12 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002961 35
  • 46.91 (n)
  • 34.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2691 35
  • 46.05 (n)
  • 32.72 (a)
CG2691 36
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y46E12BL.2 35
  • 42.72 (n)
  • 29.62 (a)
Y46E12BL.2 36
  • 25 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL014C 35
  • 40.78 (n)
  • 27.52 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F27269g 35
  • 40.15 (n)
  • 29.13 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRP12 35
  • 38.92 (n)
  • 28.63 (a)
RRP12 36
  • 24 (a)
OneToOne
RRP12 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G34357 35
  • 40.66 (n)
  • 28.3 (a)
rice
(Oryza sativa)
Liliopsida Os02g0782100 35
  • 41.31 (n)
  • 28.11 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01675 35
  • 44.98 (n)
  • 29.05 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToOne
Species with no ortholog for RRP12:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRP12 Gene

ENSEMBL:
Gene Tree for RRP12 (if available)
TreeFam:
Gene Tree for RRP12 (if available)

Paralogs for RRP12 Gene

No data available for Paralogs for RRP12 Gene

Variants for RRP12 Gene

Sequence variations from dbSNP and Humsavar for RRP12 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2275580 - 97,366,192(+) GAAGC(C/T)GTGGT reference, missense
rs1048445 - 97,357,146(-) TGCCC(A/G)GCGAG reference, missense
rs1475773 -- 97,365,054(+) CAACC(A/C)GGAAA intron-variant
rs1537645 -- 97,390,157(+) GTAAA(C/T)AGACA intron-variant
rs1537646 -- 97,390,165(+) ACATA(C/T)GGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RRP12 Gene

Variant ID Type Subtype PubMed ID
nsv831952 CNV Loss 17160897
nsv895914 CNV Gain 21882294
dgv119n27 CNV Loss 19166990
nsv825535 CNV Gain 20364138
nsv467440 CNV Loss 19166990
esv2739884 CNV Deletion 23290073
esv2739895 CNV Deletion 23290073

Variation tolerance for RRP12 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.30; 98.52% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RRP12 Gene

Disorders for RRP12 Gene

Relevant External Links for RRP12

Genetic Association Database (GAD)
RRP12
Human Genome Epidemiology (HuGE) Navigator
RRP12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RRP12

No disorders were found for RRP12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRP12 Gene

Publications for RRP12 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  3. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for RRP12 Gene

Sources for RRP12 Gene

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