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Aliases for RRP1 Gene

Aliases for RRP1 Gene

  • Ribosomal RNA Processing 1 2 3 5
  • Novel Nuclear Protein 1 3 4
  • Nucleolar Protein Nop52 3 4
  • RRP1-Like Protein 3 4
  • D21S2056E 3 4
  • NNP-1 3 4
  • NOP52 3 4
  • RRP1A 3 4
  • DNA Segment On Chromosome 21 (Unique) 2056 Expressed Sequence 2
  • Ribosomal RNA Processing 1 Homolog (S. Cerevisiae) 2
  • Ribosomal RNA Processing 1 Homolog 3
  • Nnp1 Homolog, Nucleolar Protein 3
  • Nucleolar Protein (Drosophila) 2
  • Protein NNP-1 3
  • Nnp1 Homolog 2
  • NNP1 4

External Ids for RRP1 Gene

Previous GeneCards Identifiers for RRP1 Gene

  • GC21P044035
  • GC21P045209
  • GC21P030577

Summaries for RRP1 Gene

Entrez Gene Summary for RRP1 Gene

  • The protein encoded by this gene is the putative homolog of the yeast ribosomal RNA processing protein RRP1. The encoded protein is involved in the late stages of nucleologenesis at the end of mitosis, and may be required for the generation of 28S rRNA. [provided by RefSeq, Jul 2008]

GeneCards Summary for RRP1 Gene

RRP1 (Ribosomal RNA Processing 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is RRP1B.

UniProtKB/Swiss-Prot for RRP1 Gene

  • Plays a critical role in the generation of 28S rRNA.

Gene Wiki entry for RRP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRP1 Gene

Genomics for RRP1 Gene

Regulatory Elements for RRP1 Gene

Enhancers for RRP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RRP1 on UCSC Golden Path with GeneCards custom track

Promoters for RRP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RRP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RRP1 Gene

43,789,513 bp from pter
43,805,293 bp from pter
15,781 bases
Plus strand

Genomic View for RRP1 Gene

Genes around RRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRP1 Gene

Proteins for RRP1 Gene

  • Protein details for RRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribosomal RNA processing protein 1 homolog A
    Protein Accession:
    Secondary Accessions:
    • Q9NST5

    Protein attributes for RRP1 Gene

    461 amino acids
    Molecular mass:
    52839 Da
    Quaternary structure:
    • Interacts with C1QBP.

neXtProt entry for RRP1 Gene

Proteomics data for RRP1 Gene at MOPED

Post-translational modifications for RRP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RRP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RRP1 Gene

Domains & Families for RRP1 Gene

Protein Domains for RRP1 Gene


Suggested Antigen Peptide Sequences for RRP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RRP1 family.
  • Belongs to the RRP1 family.
genes like me logo Genes that share domains with RRP1: view

No data available for Gene Families for RRP1 Gene

Function for RRP1 Gene

Molecular function for RRP1 Gene

UniProtKB/Swiss-Prot Function:
Plays a critical role in the generation of 28S rRNA.
genes like me logo Genes that share phenotypes with RRP1: view

Animal Model Products

miRNA for RRP1 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRP1 Gene

Localization for RRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRP1 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for RRP1 Gene COMPARTMENTS Subcellular localization image for RRP1 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030687 preribosome, large subunit precursor IBA --
GO:0030688 preribosome, small subunit precursor IEA --
genes like me logo Genes that share ontologies with RRP1: view

Pathways & Interactions for RRP1 Gene

SuperPathways for RRP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RRP1 Gene


No data available for Pathways by source and SIGNOR curated interactions for RRP1 Gene

Drugs & Compounds for RRP1 Gene

No Compound Related Data Available

Transcripts for RRP1 Gene

Unigene Clusters for RRP1 Gene

Ribosomal RNA processing 1 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RRP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13
SP1: -
SP2: - -
SP3: - -

Relevant External Links for RRP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RRP1 Gene

mRNA expression in normal human tissues for RRP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RRP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.3), Lung (7.9), and Pancreas (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RRP1 Gene

SOURCE GeneReport for Unigene cluster for RRP1 Gene Hs.110757

mRNA Expression by UniProt/SwissProt for RRP1 Gene

Tissue specificity: Ubiquitously expressed in fetal and adult tissues.
genes like me logo Genes that share expression patterns with RRP1: view

Protein tissue co-expression partners for RRP1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for RRP1 Gene

Orthologs for RRP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RRP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RRP1 35
  • 75.69 (n)
  • 69.72 (a)
RRP1 36
  • 66 (a)
(Canis familiaris)
Mammalia RRP1 35
  • 76.58 (n)
  • 70.47 (a)
RRP1 36
  • 62 (a)
(Pan troglodytes)
Mammalia RRP1 35
  • 99.06 (n)
  • 99.57 (a)
RRP1 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Rrp1 35
  • 75.98 (n)
  • 72.3 (a)
(Monodelphis domestica)
Mammalia RRP1 36
  • 35 (a)
(Mus musculus)
Mammalia Rrp1 36
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia RRP1 36
  • 55 (a)
(Gallus gallus)
Aves RRP1B 36
  • 28 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8175 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4334 35
(Danio rerio)
Actinopterygii rrp1 36
  • 26 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nnp-1 36
  • 15 (a)
(Caenorhabditis elegans)
Secernentea C47E12.7 35
  • 43.07 (n)
  • 33.21 (a)
C47E12.7 36
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRP1 36
  • 25 (a)
Species with no ortholog for RRP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRP1 Gene

Gene Tree for RRP1 (if available)
Gene Tree for RRP1 (if available)

Paralogs for RRP1 Gene

Paralogs for RRP1 Gene

(1) SIMAP similar genes for RRP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RRP1: view

Variants for RRP1 Gene

Sequence variations from dbSNP and Humsavar for RRP1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs34224504 - 43,797,658(-) GTCGA(A/C/T)GAACT reference, missense
rs915770 - 43,800,602(+) CTACA(A/G)AGTGA reference, missense
rs2276244 -- 43,789,561(+) GGGCG(C/T)AGGAG upstream-variant-2KB, utr-variant-5-prime
rs2276245 -- 43,789,833(+) GCGGC(C/T)GGAGC intron-variant, upstream-variant-2KB
rs2276246 -- 43,791,051(+) AAACC(A/G)TCAAG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RRP1 Gene

Variant ID Type Subtype PubMed ID
dgv4761n71 CNV Loss 21882294
nsv509799 CNV Insertion 20534489
nsv913879 CNV Gain 21882294
nsv470904 CNV Loss 18288195
nsv913882 CNV Loss 21882294
nsv834107 CNV Loss 17160897
esv33817 CNV Loss 17666407
nsv520305 CNV Loss 19592680
nsv834108 CNV Loss 17160897
dgv4763n71 CNV Loss 21882294
nsv913885 CNV Loss 21882294
nsv522204 CNV Loss 19592680
nsv913886 CNV Loss 21882294

Variation tolerance for RRP1 Gene

Residual Variation Intolerance Score: 78.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.77; 89.46% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RRP1 Gene

Disorders for RRP1 Gene

Relevant External Links for RRP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RRP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRP1 Gene

Publications for RRP1 Gene

  1. The nucleolar antigen Nop52, the human homologue of the yeast ribosomal RNA processing RRP1, is recruited at late stages of nucleologenesis. (PMID: 10341208) Savino T.M. … Hernandez-Verdun D. (J. Cell Sci. 1999) 2 3 4 23 67
  2. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 2 3
  3. The NNP-1 gene (D21S2056E), which encodes a novel nuclear protein, maps in close proximity to the cystatin B gene within the EPM1 and APECED critical region on 21q22.3. (PMID: 9192856) Jansen E. … Van de Ven W.J.M. (Genomics 1997) 3 23
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  5. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3

Products for RRP1 Gene

Sources for RRP1 Gene