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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RRP1 Gene

protein-coding   GIFtS: 49
GCID: GC21P045209

ribosomal RNA processing 1 homolog (S. cerevisiae)

 Explore 3 diseases affiliated with
RRP1 via our new
 Human Malady Compendium 
Biological research products
for RRP1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ribosomal RNA Processing 1 Homolog (S. Cerevisiae)1 2     RRP1-Like Protein2 3
D21S2056E1 2 3     Nop521
NNP-11 2 3     Nnp1 Homolog, Nucleolar Protein2
NOP521 2 3     Protein NNP-12
RRP1A1 2 3     Ribosomal RNA Processing Protein 1 Homolog A2
Novel Nuclear Protein 12 3     NNP13
Nucleolar Protein Nop522 3     

External Ids:    HGNC: 187851   Entrez Gene: 85682   Ensembl: ENSG000001602147   OMIM: 6106535   UniProtKB: P561823   

Export aliases for RRP1 gene to outside databases

Previous GC identifers: GC21P044035 GC21P030577


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RRP1:
The protein encoded by this gene is the putative homolog of the yeast ribosomal RNA processing protein RRP1. The
encoded protein is involved in the late stages of nucleologenesis at the end of mitosis, and may be required for the
generation of 28S rRNA. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RRP1_HUMAN, P56182
Function: Plays a critical role in the generation of 28S rRNA

Gene Wiki entry for RRP1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011515.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RRP1 gene promoter:
         SRF   USF1   SRF (504 AA)   USF2   AP-4   USF-1:USF-2   Max   USF-1   ATF   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRRP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RRP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RRP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3

RRP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RRP1 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21P045209:  view genomic region     (about GC identifiers)

Start:
45,209,394 bp from pter      End:
45,225,174 bp from pter
Size:
15,781 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RRP1_HUMAN, P56182 (See protein sequence)
Recommended Name: Ribosomal RNA processing protein 1 homolog A  
Size: 461 amino acids; 52839 Da
Subunit: Interacts with C1QBP
Subcellular location: Nucleus, nucleolus
Secondary accessions: Q9NST5

Explore the universe of human proteins at neXtProt for RRP1: NX_P56182

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P56182

  • RRP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003674.1  
    ENSEMBL proteins: 
     ENSP00000417464   ENSP00000426898  

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    Novus Biologicals RRP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RRP1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS9192856
    GO:0005730nucleolus IDA--
    GO:0030688preribosome, small subunit precursor IEA--


    RRP1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RRP1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR010301 Nop52

    Graphical View of Domain Structure for InterPro Entry P56182

    ProtoNet protein and cluster: P56182

    1 Blocks protein family: IPB010301 Nucleolar

    UniProtKB/Swiss-Prot: RRP1_HUMAN, P56182
    Similarity: Belongs to the RRP1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: RRP1_HUMAN, P56182
    Function: Plays a critical role in the generation of 28S rRNA

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RRP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/9 Interacting proteins for RRP1 (P561823 ENSP000004174644) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    GABARAPO951663I2D: score=1 
    MAP1LC3AQ9H4923I2D: score=1 
    RRP1BENSP000003391454STRING: ENSP00000339145
    HDGFENSP000003571894STRING: ENSP00000357189
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364rRNA processing IEA--


    RRP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RRP1
    Search CenterWatch for drugs/clinical trials and news about RRP1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RRP1 gene: 
    NM_003683.5  

    Unigene Cluster for RRP1:

    Ribosomal RNA processing 1 homolog (S. cerevisiae)
    Hs.110757  [show with all ESTs]
    Unigene Representative Sequence: BC000380
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475534 ENST00000497547(uc011aez.1 uc002zds.2) ENST00000483896
    ENST00000291569 ENST00000492638 ENST00000473988 ENST00000467112(uc010gpl.1)
    ENST00000471909(uc010gpm.1)

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    Inhib. RNA
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    Additional cDNA sequence: 

    AK223185.1 AK223215.1 AK303000.1 AK313116.1 BC000380.2 BC014787.1 U79775.1 

    17 DOTS entries:

    DT.312327  DT.100794745  DT.100794748  DT.121139128  DT.40203772  DT.100794744  DT.92436490  DT.450248 
    DT.95311650  DT.121139140  DT.100667985  DT.100794741  DT.100794742  DT.121139139  DT.121139136  DT.91686845 
    DT.92443884 

    24/204 AceView cDNA sequences (see all 204):

    BM463832 BQ278599 BX280862 BU535544 BQ016964 BM044169 BG747599 F36453 
    CR615660 BQ439941 BU158549 BI223794 BM475008 CB853658 BQ706649 CA388865 
    BE796449 BM468399 CK904565 BM054869 CR603110 BM811195 AI167158 BU943979 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RRP1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13
    SP1:                                                                    -                                             
    SP2:              -                                                     -                                             
    SP3:              -                                                     -                                             
    SP4:                                                                                                                  
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for RRP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RRP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGAGGAAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See RRP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RRP1

    SOURCE GeneReport for Unigene cluster: Hs.110757

    UniProtKB/Swiss-Prot: RRP1_HUMAN, P56182
    Tissue specificity: Ubiquitously expressed in fetal and adult tissues

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RRP1 gene from 9/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rrp11 , 5 ribosomal RNA processing 1 homolog (S. cerevisiae)1, 5 77.94(n)1
    73.76(a)1
      10 (39.72 cM)5
    181141  NM_010925.21  NP_035055.21 
     784003625 
    chicken
    (Gallus gallus)
    Aves RRP1B6
    hypothetical protein LOC425237
    27(a)
    1 → many
    1(113488233-113516743)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    27(a)
    1 → many
    3(136737134-136765576)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.81752 Transcribed sequence with weak similarity to protein more 73.41(n)    141994033 
    zebrafish
    (Danio rerio)
    Actinopterygii rrp16
    ribosomal RNA processing 1 homolog (S. cerevisiae)...
    25(a)
    1 → many
    9(287537-296100)
    fruit fly
    (Drosophila melanogaster)
    Insecta Nnp-11 CG12396-PA 43.65(n)
    31.56(a)
      44391  NM_143719.2  NP_651976.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C47E12.76
    Ribosomal RNA processing protein 1 homolog
    24(a)
    1 → many
    IV(9980703-9982255)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G206006
    uncharacterized protein
    16(a)
    1 → many
    5(6966178-6968033)
    rice
    (Oryza sativa)
    Liliopsida --
    nucleolar protein,Nop52 containing protein, expres...
    14(a)
    1 → many
    4(33404716-33406725)


    ENSEMBL Gene Tree for RRP1 (if available)
    TreeFam Gene Tree for RRP1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RRP1 gene
    RRP1B2  
    1 SIMAP similar gene for RRP1 using alignment to 3 protein entries:     RRP1_HUMAN (see all proteins):
    RRP1B

    RRP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/366 NCBI SNPs in RRP1 are shown (see all 366    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1448951851,2
    --45207423(+) GTTAAC/TATGAG 1 -- us2k10--------
    rs1387862671,2
    --45207430(+) TGAGGA/TCATGC 1 -- us2k10--------
    rs1404565271,2
    --45207623(+) AAACAC/GAAAAA 1 -- us2k10--------
    rs1504193091,2
    --45207701(+) CAGCCC/TGGGCG 1 -- us2k10--------
    rs1129885561,2
    C,--45207717(+) TGAAACT/-CTGTC 1 -- us2k11Minor allele frequency- -:0.00CSA 2
    rs1129947031,2
    C,--45207845(+) GTGGCA/CGGATC 1 -- us2k12Minor allele frequency- C:0.00WA CSA 3
    rs1495958871,2
    --45207908(+) CCTCCC/TGAGTA 1 -- us2k10--------
    rs124837061,2
    C,H,--45208030(+) CCACCT/CGCTTT 1 -- us2k13Minor allele frequency- C:0.24NA CSA 124
    rs99849291,2
    C,F,--45208097(+) CAACTT/GTTTAT 1 -- us2k11Minor allele frequency- G:0.09WA 118
    rs2000214351,2
    --45208144(+) TCAAT-/GAAGACCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RRP1 (45209394 - 45225174 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for RRP1
         3 CNVs: 30145 5162 7327

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RRP1 for disorders           About GeneDecksing

    OMIM gene information: 610653    OMIM disorders: --

    3 diseases for RRP1:    About MalaCards
    lyme disease    keloids    neuroblastoma

    Human Genome Epidemiology (HuGE) Navigator: RRP1 (4 documents)

    Export disorders for RRP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RRP1 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with RRP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The nucleolar antigen Nop52, the human homologue of the yeast ribosomal RNA processing RRP1, is recruited at late stages of nucleologenesis. (PubMed id 10341208)1, 2, 3, 9 Savino T.M....Hernandez-Verdun D. (1999)
    2. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2, 3 Hattori M....Yaspo M.L. (2000)
    3. The NNP-1 gene (D21S2056E), which encodes a novel nuclear protein, maps in close proximity to the cystatin B gene within the EPM1 and APECED critical region on 21q22.3. (PubMed id 9192856)1, 2, 9 Jansen E.... Van de Ven W.J.M. (1997)
    4. Splicing factor 2-associated protein p32 participates in ribosome biogenesis by regulating the binding of Nop52 and fibrillarin to pre ribosome particles. (PubMed id 21536856)1, 2 Yoshikawa H....Takahashi N. (2011)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    8. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8568 HGNC: 18785 AceView: D21S2056E Ensembl:ENSG00000160214 euGenes: HUgn8568
    ECgene: RRP1 H-InvDB: RRP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RRP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RRP1 gene:
    Search GeneIP for patents involving RRP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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