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Aliases for RRNAD1 Gene

Aliases for RRNAD1 Gene

  • Ribosomal RNA Adenine Dimethylase Domain Containing 1 2 3
  • Ribosomal RNA Adenine Dimethylase Domain-Containing Protein 1 3 4
  • C1orf66 3 4
  • Chromosome 1 Open Reading Frame 66 2
  • Protein RRNAD1 3
  • CGI-41 3

External Ids for RRNAD1 Gene

Previous Symbols for RRNAD1 Gene

  • C1orf66

Summaries for RRNAD1 Gene

GeneCards Summary for RRNAD1 Gene

RRNAD1 (Ribosomal RNA Adenine Dimethylase Domain Containing 1) is a Protein Coding gene. Diseases associated with RRNAD1 include periodontal disease. GO annotations related to this gene include rRNA (adenine-N6,N6-)-dimethyltransferase activity. An important paralog of this gene is METTL25.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRNAD1 Gene

Genomics for RRNAD1 Gene

Genomic Location for RRNAD1 Gene

Start:
156,728,442 bp from pter
End:
156,736,960 bp from pter
Size:
8,519 bases
Orientation:
Plus strand

Genomic View for RRNAD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RRNAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRNAD1 Gene

No data available for Regulatory Elements for RRNAD1 Gene

Proteins for RRNAD1 Gene

  • Protein details for RRNAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FB5-RRNAD_HUMAN
    Recommended name:
    Protein RRNAD1
    Protein Accession:
    Q96FB5
    Secondary Accessions:
    • D3DVC7
    • Q4VX71
    • Q5SZ03
    • Q9Y358

    Protein attributes for RRNAD1 Gene

    Size:
    475 amino acids
    Molecular mass:
    52981 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD34037.1; Type=Frameshift; Positions=154, 165; Evidence={ECO:0000305};

    Alternative splice isoforms for RRNAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RRNAD1 Gene

Proteomics data for RRNAD1 Gene at MOPED

Post-translational modifications for RRNAD1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RRNAD1 Gene

Domains for RRNAD1 Gene

Protein Domains for RRNAD1 Gene

UniProtKB/Swiss-Prot:

RRNAD_HUMAN
Family:
  • Belongs to the RRNAD1 family.:
    • Q96FB5
genes like me logo Genes that share domains with RRNAD1: view

No data available for Gene Families for RRNAD1 Gene

Function for RRNAD1 Gene

Gene Ontology (GO) - Molecular Function for RRNAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA --
genes like me logo Genes that share ontologies with RRNAD1: view

Phenotypes for RRNAD1 Gene

genes like me logo Genes that share phenotypes with RRNAD1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RRNAD1 Gene

Localization for RRNAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRNAD1 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for RRNAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RRNAD1: view

Pathways for RRNAD1 Gene

SuperPathways for RRNAD1 Gene

No Data Available

Interacting Proteins for RRNAD1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357199%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000357199 for RRNAD1 Gene via STRING

Symbol External ID(s) Details
ELAVL1

Gene Ontology (GO) - Biological Process for RRNAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031167 rRNA methylation IEA --
genes like me logo Genes that share ontologies with RRNAD1: view

No data available for Pathways by source for RRNAD1 Gene

Transcripts for RRNAD1 Gene

Unigene Clusters for RRNAD1 Gene

Ribosomal RNA adenine dimethylase domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RRNAD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d · 11e ·
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5:
SP6: - - - - - -
SP7: - - - - -
SP8:
SP9: - - - - - -
SP10: - -
SP11: - -

ExUns: 11f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for RRNAD1 Gene

GeneLoc Exon Structure for
RRNAD1
ECgene alternative splicing isoforms for
RRNAD1

Expression for RRNAD1 Gene

mRNA expression in normal human tissues for RRNAD1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RRNAD1 Gene

SOURCE GeneReport for Unigene cluster for RRNAD1 Gene Hs.512597

genes like me logo Genes that share expressions with RRNAD1: view

Orthologs for RRNAD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RRNAD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RRNAD1 36
  • 98.04 (n)
  • 97.05 (a)
RRNAD1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RRNAD1 36
  • 90.46 (n)
  • 92 (a)
RRNAD1 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C1ORF66 37
  • 91 (a)
OneToOne
RRNAD1 36
  • 87.69 (n)
  • 90.72 (a)
mouse
(Mus musculus)
Mammalia Rrnad1 36
  • 85.89 (n)
  • 86.53 (a)
Rrnad1 16
Rrnad1 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RRNAD1 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rrnad1 36
  • 84.98 (n)
  • 87.37 (a)
chicken
(Gallus gallus)
Aves RRNAD1 36
  • 62.24 (n)
  • 56.19 (a)
RRNAD1 37
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RRNAD1 37
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25332 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rrnad1 36
  • 60.14 (n)
  • 59.91 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100332368 36
  • 58.08 (n)
  • 57.01 (a)
rrnad1 37
  • 41 (a)
OneToMany
rrnad1 37
  • 43 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007607 36
  • 45.14 (n)
  • 38.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2906 36
  • 45.59 (n)
  • 33.72 (a)
CG2906 37
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F25H2.12 36
  • 41.11 (n)
  • 33.41 (a)
F25H2.12 37
  • 26 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G16650 36
  • 39.97 (n)
  • 31.75 (a)
rice
(Oryza sativa)
Liliopsida Os12g0610500 36
  • 43.88 (n)
  • 35.04 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
OneToOne
Species with no ortholog for RRNAD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRNAD1 Gene

ENSEMBL:
Gene Tree for RRNAD1 (if available)
TreeFam:
Gene Tree for RRNAD1 (if available)

Paralogs for RRNAD1 Gene

Paralogs for RRNAD1 Gene

genes like me logo Genes that share paralogs with RRNAD1: view

Variants for RRNAD1 Gene

Sequence variations from dbSNP and Humsavar for RRNAD1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8658 -- 156,736,767(-) GATGT(C/G/T)TCCTC utr-variant-3-prime, nc-transcript-variant
rs3795738 -- 156,732,144(+) CTGGG(C/G)AACTC intron-variant
rs3934562 -- 156,736,493(-) TAAGG(A/C)ACACG intron-variant
rs4311877 - 156,735,801(+) CCCAC(C/G)TGGCC missense, reference, nc-transcript-variant
rs6660041 -- 156,734,508(+) GGGGA(C/T)GGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RRNAD1 Gene

Variant ID Type Subtype PubMed ID
nsv831648 CNV Loss 17160897
esv2495964 CNV Insertion 19546169
esv1475923 CNV Insertion 17803354

Relevant External Links for RRNAD1 Gene

HapMap Linkage Disequilibrium report
RRNAD1

Disorders for RRNAD1 Gene

(1) MalaCards Diseases for RRNAD1 Gene

Search for RRNAD1 Gene in MalaCards »
genes like me logo Genes that share disorders with RRNAD1: view

No data available for UniProtKB/Swiss-Prot for RRNAD1 Gene

Publications for RRNAD1 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  2. The relationship of alpha1-antitrypsin to inflammatory periodontal disease. (PMID: 310876) Peterson R.J. … Marsh C.L. (J. Periodontol. 1979) 2 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J. … Lambert J.C. (Mol. Psychiatry 2009) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for RRNAD1 Gene

Sources for RRNAD1 Gene

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