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RRNAD1 Gene

protein-coding   GIFtS: 40
GCID: GC01P156699

Ribosomal RNA Adenine Dimethylase Domain Containing 1

(Previous name: chromosome 1 open reading frame 66)
(Previous symbol: C1orf66)
  See RRNAD1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal RNA Adenine Dimethylase Domain Containing 11 2
C1orf661 2 3
Ribosomal RNA Adenine Dimethylase Domain-Containing Protein 12 3
Chromosome 1 Open Reading Frame 661
CGI-412
Protein RRNAD12

External Ids:    HGNC: 242731   Entrez Gene: 510932   Ensembl: ENSG000001433037   UniProtKB: Q96FB53   

Export aliases for RRNAD1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RRNAD1 Gene:
RRNAD1 (ribosomal RNA adenine dimethylase domain containing 1) is a protein-coding gene. Diseases associated with RRNAD1 include periodontal disease. GO annotations related to this gene include rRNA (adenine-N6,N6-)-dimethyltransferase activity. An important paralog of this gene is METTL25.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for RRNAD1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for RRNAD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RRNAD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.1   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q23.1

RRNAD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RRNAD1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P156699:  view genomic region     (about GC identifiers)

Start:
156,698,234 bp from pter      End:
156,706,752 bp from pter
Size:
8,519 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RRNAD_HUMAN, Q96FB5 (See protein sequence)
Recommended Name: Protein RRNAD1  
Size: 475 amino acids; 52981 Da
Caution: Was named RRNAD1 by HGNC because a ribosomal RNA adenine dimethylase signature is detected by PROSITE.
Howwever, it probably constitutes a false positive and the ribosomal RNA adenine dimethylase signature is not
conserved in orthologs
Sequence caution: Sequence=AAD34037.1; Type=Frameshift; Positions=154, 165;
Secondary accessions: D3DVC7 Q5SZ03 Q9Y358

Explore the universe of human proteins at neXtProt for RRNAD1: NX_Q96FB5

Explore proteomics data for RRNAD1 at MOPED


See RRNAD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001136032.1  NP_057081.3  

ENSEMBL proteins: 
 ENSP00000357201   ENSP00000357199   ENSP00000429756   ENSP00000429389   ENSP00000429053  
 ENSP00000430787   ENSP00000429800  

RRNAD1 Human Recombinant Protein Products:

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Novus Biologicals RRNAD1 Lysate
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Cloud-Clone Corp. Proteins for RRNAD1

 
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Search antibodies-online for peptides for RRNAD1

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Cloud-Clone Corp. CLIAs for RRNAD1
Search eBioscience for ELISAs for RRNAD1 
antibodies-online kits for RRNAD1 (4 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR020596 rRNA_Ade_Mease_Trfase_CS
 IPR025714 Methyltranfer_dom

Graphical View of Domain Structure for InterPro Entry Q96FB5

ProtoNet protein and cluster: Q96FB5

UniProtKB/Swiss-Prot: RRNAD_HUMAN, Q96FB5
Similarity: Belongs to the RRNAD1 family


Find genes that share domains with RRNAD1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000179rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA--
     
Find genes that share ontologies with RRNAD1           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for RRNAD1:
 Decreased nuclei size in G2M  Synthetic lethal with c-Myc af 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for RRNAD1

miRNA
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Block miRNA regulation of human, mouse, rat RRNAD1 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate RRNAD1
SwitchGear 3'UTR luciferase reporter plasmidRRNAD1 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for RRNAD1
Predesigned siRNA for gene silencing in human, mouse, rat RRNAD1

Gene Editing
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DNA2.0 Custom Protein Engineering Service for RRNAD1

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OriGene ORF clones in mouse, rat for RRNAD1
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GenScript: all cDNA clones in your preferred vector (see all 2): RRNAD1 (NM_015997)
Sino Biological Human cDNA Clone for RRNAD1
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RRNAD1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRNAD1

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRNAD1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
RRNAD_HUMAN, Q96FB5: Membrane; Single-pass membrane protein (Potential)

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with RRNAD1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RRNAD1
Interactions:

    Search GeneGlobe Interaction Network for RRNAD1

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for RRNAD1 (ENSP000003571994) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
HORMAD1ENSP000003551674STRING: ENSP00000355167
ELAVL1ENSP000003852694STRING: ENSP00000385269
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for RRNAD1 (RRNAD)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for RRNAD1 gene (2 alternative transcripts): 
NM_001142560.1  NM_015997.3  

Unigene Cluster for RRNAD1:

Ribosomal RNA adenine dimethylase domain containing 1
Hs.512597  [show with all ESTs]
Unigene Representative Sequence: NM_015997
11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000368218(uc001fpv.3) ENST00000368216(uc001fpu.3) ENST00000519086
ENST00000524343 ENST00000484742 ENST00000476229 ENST00000517871 ENST00000522237
ENST00000462397 ENST00000497515 ENST00000481920
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat RRNAD1 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate RRNAD1
SwitchGear 3'UTR luciferase reporter plasmidRRNAD1 3' UTR sequence
Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat RRNAD1
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OriGene ORF clones in mouse, rat for RRNAD1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): RRNAD1 (NM_015997)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RRNAD1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRNAD1
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for RRNAD1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RRNAD1
  QuantiTect SYBR Green Assays in human, mouse, rat RRNAD1
  QuantiFast Probe-based Assays in human, mouse, rat RRNAD1

Additional mRNA sequence: 

AF151800.1 AK000412.1 BC011382.1 

17 DOTS entries:

DT.100779599  DT.97847213  DT.115441  DT.100649415  DT.100779605  DT.100779600  DT.100031305  DT.100779606 
DT.100689872  DT.91808880  DT.100779598  DT.91751333  DT.91751334  DT.121428444  DT.97783667  DT.100698984 
DT.86841625 

Selected AceView cDNA sequences (see all 148):

AW295645 CR598294 BI518421 CR612635 CF127067 AA322393 AI457403 BX094595 
CR608863 BQ055639 Z46028 CR619536 CD672705 BM714032 CA433360 BM458614 
BU185031 BG982528 CD672620 BU182295 BM662132 AI934612 BU627014 AA974728 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for RRNAD1 (see all 11)    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d · 11e ·
SP1:              -                 -                                               -                       -                 -     -                           
SP2:                                -                                               -           -     -     -                                                   
SP3:              -                 -                       -                       -                                                                           
SP4:                                                                                -     -     -     -     -                 -     -                           
SP5:                                                                                                                                                            

ExUns: 11f
SP1:      
SP2:      
SP3:      
SP4:      
SP5:      


ECgene alternative splicing isoforms for RRNAD1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RRNAD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
RRNAD1 Expression
About this image

RRNAD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RRNAD1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.512597
    Custom PCR Arrays for RRNAD1
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QuantiFast Probe-based Assays in human, mouse, rat RRNAD1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRNAD1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for RRNAD1 gene from Selected species (see all 17)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rrnad11 , 5 ribosomal RNA adenine dimethylase domain containing more1, 5 85.89(n)1
86.53(a)1
  3 (38.78 cM)5
2295031  NM_153562.41  NP_705790.31 
 879226015 
chicken
(Gallus gallus)
Aves RRNAD11 ribosomal RNA adenine dimethylase domain containing more 62.24(n)
56.19(a)
  768974  XM_004948199.1  XP_004948256.1 
lizard
(Anolis carolinensis)
Reptilia RRNAD16
ribosomal RNA adenine dimethylase domain containin...
57(a)
1 ↔ 1
GL343640.1(229012-240755)
African clawed frog
(Xenopus laevis)
Amphibia Xl.253322 Xenopus laevis transcribed sequence with weak similarity more 74.91(n)    48028503 
zebrafish
(Danio rerio)
Actinopterygii LOC1003323681 protein RRNAD1-like 58.08(n)
57.01(a)
  100332368  XM_002664923.3  XP_002664969.1 
fruit fly
(Drosophila melanogaster)
Insecta CG29061 CG2906 45.59(n)
33.72(a)
  35753  NM_001103755.2  NP_001097225.1 
worm
(Caenorhabditis elegans)
Secernentea F25H2.121 F25H2.12 41.11(n)
33.41(a)
  172945  NM_060367.3  NP_492768.1 
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G166501 AT1G16650 39.97(n)
31.75(a)
  838234  NM_101526.2  NP_173110.2 
rice
(Oryza sativa)
Liliopsida Os12g06105001 Os12g0610500 43.88(n)
35.04(a)
  4352762  NM_001073779.1  NP_001067247.1 


ENSEMBL Gene Tree for RRNAD1 (if available)
TreeFam Gene Tree for RRNAD1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RRNAD1 gene
METTL252  

Find genes that share paralogs with RRNAD1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RRNAD1 (see all 188)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1841648211,2
--156699706(+) CATCAC/TTGATT 2 -- int10--------
rs1907200851,2
--156699793(+) ATTCAC/TCCATT 2 -- int10--------
rs1820140201,2
--156699846(+) CACCTC/GTCTTC 2 -- int10--------
rs1378756601,2
C--156699943(+) TCAAAC/TGTAAA 2 -- int10--------
rs761144421,2
C,F--156699977(+) TCCTAG/AATACT 2 -- int13Minor allele frequency- A:0.15WA NA EA 358
rs1862337291,2
--156700056(+) TCTATC/GCCATT 2 -- int10--------
rs1494877551,2
--156700160(+) TCTTCC/TGCCAC 2 -- int10--------
rs1439198341,2
C--156700197(+) AACAAA/GGACTC 2 -- int10--------
rs1389303961,2
C--156700363(+) AAAAT-/AAAAAT 2 -- int10--------
rs66614131,2
C,H--156700368(+) taaaaA/Taaaaa 2 -- int18Minor allele frequency- T:0.04NA WA CSA EA 249

HapMap Linkage Disequilibrium report for RRNAD1 (156698234 - 156706752 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for RRNAD1:    About this table    
Variant IDTypeSubtypePubMed ID
esv1475923CNV Insertion17803354
esv2495964CNV Insertion19546169
nsv831648CNV Loss17160897

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing RRNAD1
DNA2.0 Custom Variant and Variant Library Synthesis for RRNAD1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for RRNAD1:    
About MalaCards
periodontal disease


Find genes that share disorders with RRNAD1           About GenesLikeMe


Export disorders for RRNAD1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RRNAD1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with RRNAD1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
  2. The relationship of alpha1-antitrypsin to inflammatory periodontal disease. (PubMed id 310876)1, 3 Peterson R.J. and Marsh C.L. (J. Periodontol. 1979)
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
  4. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1 Chapuis J....Lambert J.C. (Mol. Psychiatry 2009)
  5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51093 HGNC: 24273 AceView: CGI-41 Ensembl:ENSG00000143303 euGenes: HUgn51093
ECgene: RRNAD1 H-InvDB: RRNAD1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RRNAD1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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