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Aliases for RRNAD1 Gene

Aliases for RRNAD1 Gene

  • Ribosomal RNA Adenine Dimethylase Domain Containing 1 2 3 5
  • Ribosomal RNA Adenine Dimethylase Domain-Containing Protein 1 3 4
  • C1orf66 3 4
  • Chromosome 1 Open Reading Frame 66 2
  • CGI-41 3

External Ids for RRNAD1 Gene

Previous HGNC Symbols for RRNAD1 Gene

  • C1orf66

Summaries for RRNAD1 Gene

GeneCards Summary for RRNAD1 Gene

RRNAD1 (Ribosomal RNA Adenine Dimethylase Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include rRNA (adenine-N6,N6-)-dimethyltransferase activity. An important paralog of this gene is METTL25.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRNAD1 Gene

Genomics for RRNAD1 Gene

Regulatory Elements for RRNAD1 Gene

Promoters for RRNAD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RRNAD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RRNAD1 Gene

Chromosome:
1
Start:
156,728,442 bp from pter
End:
156,736,960 bp from pter
Size:
8,519 bases
Orientation:
Plus strand

Genomic View for RRNAD1 Gene

Genes around RRNAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRNAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRNAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRNAD1 Gene

Proteins for RRNAD1 Gene

  • Protein details for RRNAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FB5-RRNAD_HUMAN
    Recommended name:
    Protein RRNAD1
    Protein Accession:
    Q96FB5
    Secondary Accessions:
    • D3DVC7
    • Q4VX71
    • Q5SZ03
    • Q9Y358

    Protein attributes for RRNAD1 Gene

    Size:
    475 amino acids
    Molecular mass:
    52981 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD34037.1; Type=Frameshift; Positions=154, 165; Evidence={ECO:0000305};

    Alternative splice isoforms for RRNAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RRNAD1 Gene

Proteomics data for RRNAD1 Gene at MOPED

Post-translational modifications for RRNAD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RRNAD1 Gene

Domains & Families for RRNAD1 Gene

Gene Families for RRNAD1 Gene

Protein Domains for RRNAD1 Gene

Suggested Antigen Peptide Sequences for RRNAD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96FB5

UniProtKB/Swiss-Prot:

RRNAD_HUMAN :
  • Belongs to the RRNAD1 family.
Family:
  • Belongs to the RRNAD1 family.
genes like me logo Genes that share domains with RRNAD1: view

Function for RRNAD1 Gene

genes like me logo Genes that share phenotypes with RRNAD1: view

Animal Model Products

CRISPR Products

miRNA for RRNAD1 Gene

miRTarBase miRNAs that target RRNAD1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRNAD1 Gene

Localization for RRNAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRNAD1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RRNAD1 Gene COMPARTMENTS Subcellular localization image for RRNAD1 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for RRNAD1 Gene

Pathways & Interactions for RRNAD1 Gene

SuperPathways for RRNAD1 Gene

No Data Available

Interacting Proteins for RRNAD1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357199%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000357199 for RRNAD1 Gene via STRING

Symbol External ID(s) Details
ELAVL1

Gene Ontology (GO) - Biological Process for RRNAD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RRNAD1 Gene

Drugs & Compounds for RRNAD1 Gene

No Compound Related Data Available

Transcripts for RRNAD1 Gene

Unigene Clusters for RRNAD1 Gene

Ribosomal RNA adenine dimethylase domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RRNAD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d · 11e ·
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5:
SP6: - - - - - -
SP7: - - - - -
SP8:
SP9: - - - - - -
SP10: - -
SP11: - -

ExUns: 11f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for RRNAD1 Gene

GeneLoc Exon Structure for
RRNAD1
ECgene alternative splicing isoforms for
RRNAD1

Expression for RRNAD1 Gene

mRNA expression in normal human tissues for RRNAD1 Gene

Protein differential expression in normal tissues from HIPED for RRNAD1 Gene

This gene is overexpressed in Bone marrow stromal cell (58.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RRNAD1 Gene



SOURCE GeneReport for Unigene cluster for RRNAD1 Gene Hs.512597

genes like me logo Genes that share expression patterns with RRNAD1: view

Protein tissue co-expression partners for RRNAD1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RRNAD1 Gene

Orthologs for RRNAD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RRNAD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RRNAD1 35
  • 90.46 (n)
  • 92 (a)
RRNAD1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RRNAD1 35
  • 87.69 (n)
  • 90.72 (a)
C1ORF66 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rrnad1 35
  • 85.89 (n)
  • 86.53 (a)
Rrnad1 16
Rrnad1 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RRNAD1 35
  • 98.04 (n)
  • 97.05 (a)
RRNAD1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rrnad1 35
  • 84.98 (n)
  • 87.37 (a)
oppossum
(Monodelphis domestica)
Mammalia RRNAD1 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves RRNAD1 35
  • 62.24 (n)
  • 56.19 (a)
RRNAD1 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RRNAD1 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rrnad1 35
  • 60.14 (n)
  • 59.91 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25332 35
zebrafish
(Danio rerio)
Actinopterygii LOC100332368 35
  • 58.08 (n)
  • 57.01 (a)
rrnad1 36
  • 41 (a)
OneToMany
rrnad1 36
  • 43 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007607 35
  • 45.14 (n)
  • 38.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2906 35
  • 45.59 (n)
  • 33.72 (a)
CG2906 36
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F25H2.12 35
  • 41.11 (n)
  • 33.41 (a)
F25H2.12 36
  • 26 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G16650 35
  • 39.97 (n)
  • 31.75 (a)
rice
(Oryza sativa)
Liliopsida Os12g0610500 35
  • 43.88 (n)
  • 35.04 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToOne
Species with no ortholog for RRNAD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRNAD1 Gene

ENSEMBL:
Gene Tree for RRNAD1 (if available)
TreeFam:
Gene Tree for RRNAD1 (if available)

Paralogs for RRNAD1 Gene

Paralogs for RRNAD1 Gene

genes like me logo Genes that share paralogs with RRNAD1: view

Variants for RRNAD1 Gene

Sequence variations from dbSNP and Humsavar for RRNAD1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4311877 - 156,735,801(+) CCCAC(C/G)TGGCC nc-transcript-variant, reference, missense
rs8658 -- 156,736,767(-) GATGT(C/G/T)TCCTC nc-transcript-variant, utr-variant-3-prime
rs3795738 -- 156,732,144(+) CTGGG(A/C/G)AACTC intron-variant
rs3934562 -- 156,736,493(-) TAAGG(A/C)ACACG intron-variant
rs6660041 -- 156,734,508(+) GGGGA(C/T)GGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RRNAD1 Gene

Variant ID Type Subtype PubMed ID
nsv831648 CNV Loss 17160897
esv2495964 CNV Insertion 19546169
esv1475923 CNV Insertion 17803354

Variation tolerance for RRNAD1 Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRNAD1 Gene

HapMap Linkage Disequilibrium report
RRNAD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRNAD1 Gene

Disorders for RRNAD1 Gene

Relevant External Links for RRNAD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RRNAD1

No disorders were found for RRNAD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRNAD1 Gene

Publications for RRNAD1 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 67
  2. The relationship of alpha1-antitrypsin to inflammatory periodontal disease. (PMID: 310876) Peterson R.J. … Marsh C.L. (J. Periodontol. 1979) 2 3
  3. Discovery and refinement of loci associated with lipid levels. (PMID: 24097068) . … Abecasis G.R. (Nat. Genet. 2013) 3
  4. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J. … Lambert J.C. (Mol. Psychiatry 2009) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for RRNAD1 Gene

Sources for RRNAD1 Gene

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