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Aliases for RRNAD1 Gene

Aliases for RRNAD1 Gene

  • Ribosomal RNA Adenine Dimethylase Domain Containing 1 2 3 5
  • Ribosomal RNA Adenine Dimethylase Domain-Containing Protein 1 3 4
  • C1orf66 3 4
  • Chromosome 1 Open Reading Frame 66 2
  • Protein RRNAD1 3
  • METTL25B 3
  • CGI-41 3

External Ids for RRNAD1 Gene

Previous HGNC Symbols for RRNAD1 Gene

  • C1orf66

Summaries for RRNAD1 Gene

GeneCards Summary for RRNAD1 Gene

RRNAD1 (Ribosomal RNA Adenine Dimethylase Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include rRNA (adenine-N6,N6-)-dimethyltransferase activity. An important paralog of this gene is METTL25.

Additional gene information for RRNAD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRNAD1 Gene

Genomics for RRNAD1 Gene

Regulatory Elements for RRNAD1 Gene

Enhancers for RRNAD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H156656 2.6 VISTA FANTOM5 Ensembl ENCODE dbSUPER 54.3 -64.2 -64184 15 MLX ZFP64 DMAP1 ZNF416 ZNF143 SP3 MCM3 ZC3H11A SSRP1 ZNF610 GON4L KIAA0907 LOC246784 RRNAD1 PRCC MSTO2P LMNA ISG20L2 YY1AP1 TSACC
GH01H156486 2.1 FANTOM5 Ensembl ENCODE dbSUPER 55.2 -229.6 -229579 25 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZNF610 GLIS1 RRNAD1 GON4L KIAA0907 ENSG00000271267 MSTO2P MSTO1 LOC246784 ISG20L2 ENSG00000246203 MEF2D
GH01H156111 1.8 FANTOM5 ENCODE dbSUPER 63.3 -607.1 -607053 19 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 GON4L CLK2 RRNAD1 KIAA0907 LOC246784 LMNA MSTO1 MSTO2P PRCC ISG20L2
GH01H156765 1.7 Ensembl ENCODE dbSUPER 51.2 +39.5 39504 4 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 RRNAD1 GON4L KIAA0907 LOC246784 ISG20L2 CCT3 MRPL24 LRRC71 ENSG00000229961 ENSG00000233712
GH01H156689 1.9 FANTOM5 Ensembl ENCODE dbSUPER 34.1 -36.4 -36443 5 HDGF PKNOX1 ARNT ARID4B SIN3A ZBTB7B SLC30A9 ZNF766 ZNF143 FOS RRNAD1 KIAA0907 GON4L MSTO2P CCT3 LOC105371453 BCAN ISG20L2 HDGF LOC246784
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RRNAD1 on UCSC Golden Path with GeneCards custom track

Promoters for RRNAD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014244 258 1801 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF207 ZNF143

Genomic Location for RRNAD1 Gene

Chromosome:
1
Start:
156,728,442 bp from pter
End:
156,736,960 bp from pter
Size:
8,519 bases
Orientation:
Plus strand

Genomic View for RRNAD1 Gene

Genes around RRNAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRNAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRNAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRNAD1 Gene

Proteins for RRNAD1 Gene

  • Protein details for RRNAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FB5-RRNAD_HUMAN
    Recommended name:
    Protein RRNAD1
    Protein Accession:
    Q96FB5
    Secondary Accessions:
    • D3DVC7
    • Q4VX71
    • Q5SZ03
    • Q9Y358

    Protein attributes for RRNAD1 Gene

    Size:
    475 amino acids
    Molecular mass:
    52981 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD34037.1; Type=Frameshift; Positions=154, 165; Evidence={ECO:0000305};

    Alternative splice isoforms for RRNAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RRNAD1 Gene

Post-translational modifications for RRNAD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RRNAD1 Gene

Domains & Families for RRNAD1 Gene

Gene Families for RRNAD1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for RRNAD1 Gene

Suggested Antigen Peptide Sequences for RRNAD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96FB5

UniProtKB/Swiss-Prot:

RRNAD_HUMAN :
  • Belongs to the RRNAD1 family.
Family:
  • Belongs to the RRNAD1 family.
genes like me logo Genes that share domains with RRNAD1: view

Function for RRNAD1 Gene

Phenotypes From GWAS Catalog for RRNAD1 Gene

Gene Ontology (GO) - Molecular Function for RRNAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA --
GO:0008649 rRNA methyltransferase activity IEA --
genes like me logo Genes that share ontologies with RRNAD1: view
genes like me logo Genes that share phenotypes with RRNAD1: view

Animal Model Products

CRISPR Products

miRNA for RRNAD1 Gene

miRTarBase miRNAs that target RRNAD1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RRNAD1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRNAD1 Gene

Localization for RRNAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRNAD1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRNAD1 gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RRNAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RRNAD1: view

Pathways & Interactions for RRNAD1 Gene

SuperPathways for RRNAD1 Gene

No Data Available

Interacting Proteins for RRNAD1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357199%0d%0a9606.ENSP00000193322%0d%0a
Selected Interacting proteins: Q96FB5-RRNAD_HUMAN ENSP00000357199 for RRNAD1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for RRNAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031167 rRNA methylation IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with RRNAD1: view

No data available for Pathways by source and SIGNOR curated interactions for RRNAD1 Gene

Drugs & Compounds for RRNAD1 Gene

No Compound Related Data Available

Transcripts for RRNAD1 Gene

Unigene Clusters for RRNAD1 Gene

Ribosomal RNA adenine dimethylase domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RRNAD1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RRNAD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d · 11e ·
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5:
SP6: - - - - - -
SP7: - - - - -
SP8:
SP9: - - - - - -
SP10: - -
SP11: - -

ExUns: 11f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for RRNAD1 Gene

GeneLoc Exon Structure for
RRNAD1
ECgene alternative splicing isoforms for
RRNAD1

Expression for RRNAD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RRNAD1 Gene

Protein differential expression in normal tissues from HIPED for RRNAD1 Gene

This gene is overexpressed in Bone marrow stromal cell (58.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RRNAD1 Gene



Protein tissue co-expression partners for RRNAD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RRNAD1 Gene:

RRNAD1

SOURCE GeneReport for Unigene cluster for RRNAD1 Gene:

Hs.512597

Evidence on tissue expression from TISSUES for RRNAD1 Gene

  • Eye(4.3)
genes like me logo Genes that share expression patterns with RRNAD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RRNAD1 Gene

Orthologs for RRNAD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RRNAD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RRNAD1 33 34
  • 98.04 (n)
dog
(Canis familiaris)
Mammalia C1ORF66 34
  • 91 (a)
OneToOne
RRNAD1 33
  • 87.69 (n)
cow
(Bos Taurus)
Mammalia RRNAD1 33 34
  • 90.46 (n)
mouse
(Mus musculus)
Mammalia Rrnad1 33 16 34
  • 85.89 (n)
rat
(Rattus norvegicus)
Mammalia Rrnad1 33
  • 84.98 (n)
oppossum
(Monodelphis domestica)
Mammalia RRNAD1 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves RRNAD1 33 34
  • 62.24 (n)
lizard
(Anolis carolinensis)
Reptilia RRNAD1 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rrnad1 33
  • 60.14 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25332 33
zebrafish
(Danio rerio)
Actinopterygii LOC100332368 33
  • 58.08 (n)
rrnad1 34 34
  • 41 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG2906 33 34
  • 45.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007607 33
  • 45.14 (n)
worm
(Caenorhabditis elegans)
Secernentea F25H2.12 33 34
  • 41.11 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G16650 33
  • 39.97 (n)
rice
(Oryza sativa)
Liliopsida Os12g0610500 33
  • 43.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
OneToOne
Species where no ortholog for RRNAD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRNAD1 Gene

ENSEMBL:
Gene Tree for RRNAD1 (if available)
TreeFam:
Gene Tree for RRNAD1 (if available)

Paralogs for RRNAD1 Gene

Paralogs for RRNAD1 Gene

genes like me logo Genes that share paralogs with RRNAD1: view

Variants for RRNAD1 Gene

Sequence variations from dbSNP and Humsavar for RRNAD1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000265049 -- 156,735,212(+) TGAAC(C/G)CGGGA intron-variant
rs1000402548 -- 156,731,851(+) AGGAG(G/T)TACCT intron-variant
rs1000456130 -- 156,731,518(+) TTGAT(G/T)TATAA intron-variant
rs1000639299 -- 156,734,891(+) GAAAA(C/T)CTAAG intron-variant
rs1001183087 -- 156,729,224(+) AGGCC(A/G)CAGGG intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RRNAD1 Gene

Variant ID Type Subtype PubMed ID
esv1475923 CNV insertion 17803354
esv2495964 CNV insertion 19546169
esv3326332 CNV duplication 20981092
esv3578200 CNV loss 25503493
nsv831648 CNV loss 17160897

Variation tolerance for RRNAD1 Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRNAD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RRNAD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRNAD1 Gene

Disorders for RRNAD1 Gene

Relevant External Links for RRNAD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RRNAD1

No disorders were found for RRNAD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRNAD1 Gene

Publications for RRNAD1 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 60
  2. The relationship of alpha1-antitrypsin to inflammatory periodontal disease. (PMID: 310876) Peterson RJ … Marsh CL (Journal of periodontology 1979) 2 3 60
  3. Discovery and refinement of loci associated with lipid levels. (PMID: 24097068) Global Lipids Genetics Consortium … Abecasis GR (Nature genetics 2013) 3 60
  4. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J … Lambert JC (Molecular psychiatry 2009) 3 60
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 60

Products for RRNAD1 Gene

Sources for RRNAD1 Gene

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