Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RRNAD1 Gene

Aliases for RRNAD1 Gene

  • Ribosomal RNA Adenine Dimethylase Domain Containing 1 2 3 5
  • Ribosomal RNA Adenine Dimethylase Domain-Containing Protein 1 3 4
  • C1orf66 3 4
  • Chromosome 1 Open Reading Frame 66 2
  • Protein RRNAD1 3
  • METTL25B 3
  • CGI-41 3

External Ids for RRNAD1 Gene

Previous HGNC Symbols for RRNAD1 Gene

  • C1orf66

Summaries for RRNAD1 Gene

GeneCards Summary for RRNAD1 Gene

RRNAD1 (Ribosomal RNA Adenine Dimethylase Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include rRNA (adenine-N6,N6-)-dimethyltransferase activity. An important paralog of this gene is METTL25.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRNAD1 Gene

Genomics for RRNAD1 Gene

Regulatory Elements for RRNAD1 Gene

Enhancers for RRNAD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F156486 1.9 FANTOM5 Ensembl ENCODE 60.3 -229.6 -229579 25.4 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 RRNAD1 KIAA0907 LOC246784 ENSG00000271267 SSR2 GLMP MEF2D ENSG00000229961 DAP3P1 TSACC
GH01F155856 1.5 FANTOM5 ENCODE 55.1 -869.5 -869493 5.7 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 RRNAD1 KIAA0907 ENSG00000271267 MSTO2P THBS3 ASH1L-AS1 LOC101928120 PYGO2 KRTCAP2 DCST1
GH01F156456 1.6 FANTOM5 ENCODE 51.5 -271.1 -271066 2.7 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 KIAA0907 RRNAD1 ENSG00000271267 LOC246784 SSR2 ENSG00000229961 DAP3P1 TSACC ARHGEF2 C1orf61
GH01F156740 1.6 FANTOM5 ENCODE 45.5 +18.4 18421 13.6 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 RRNAD1 KIAA0907 LOC246784 SSR2 PEAR1 HDGF ETV3 LOC105371454 GLMP RIT1
GH01F156111 1.6 FANTOM5 ENCODE 30.6 -607.1 -607053 19.4 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 KIAA0907 MSTO2P ENSG00000271267 RRNAD1 LMNA ASH1L LOC246784 PEAR1 MEX3A DPM3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RRNAD1 on UCSC Golden Path with GeneCards custom track

Promoters for RRNAD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001750542 -1742 201 HDGF HDAC1 INSM2 KLF17 ARID4B DMAP1 ZNF2 RAD21 ZEB1 ZNF366

Genomic Location for RRNAD1 Gene

156,728,442 bp from pter
156,736,960 bp from pter
8,519 bases
Plus strand

Genomic View for RRNAD1 Gene

Genes around RRNAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRNAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRNAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRNAD1 Gene

Proteins for RRNAD1 Gene

  • Protein details for RRNAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein RRNAD1
    Protein Accession:
    Secondary Accessions:
    • D3DVC7
    • Q4VX71
    • Q5SZ03
    • Q9Y358

    Protein attributes for RRNAD1 Gene

    475 amino acids
    Molecular mass:
    52981 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD34037.1; Type=Frameshift; Positions=154, 165; Evidence={ECO:0000305};

    Alternative splice isoforms for RRNAD1 Gene


neXtProt entry for RRNAD1 Gene

Post-translational modifications for RRNAD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RRNAD1 Gene

Domains & Families for RRNAD1 Gene

Gene Families for RRNAD1 Gene

Protein Domains for RRNAD1 Gene

Suggested Antigen Peptide Sequences for RRNAD1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RRNAD1 family.
  • Belongs to the RRNAD1 family.
genes like me logo Genes that share domains with RRNAD1: view

Function for RRNAD1 Gene

Gene Ontology (GO) - Molecular Function for RRNAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA --
GO:0008649 rRNA methyltransferase activity IEA --
genes like me logo Genes that share ontologies with RRNAD1: view
genes like me logo Genes that share phenotypes with RRNAD1: view

Animal Model Products

miRNA for RRNAD1 Gene

miRTarBase miRNAs that target RRNAD1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRNAD1 Gene

Localization for RRNAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRNAD1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRNAD1 gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RRNAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RRNAD1: view

Pathways & Interactions for RRNAD1 Gene

SuperPathways for RRNAD1 Gene

No Data Available

Interacting Proteins for RRNAD1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000357199 Q96FB5-RRNAD_HUMAN for RRNAD1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for RRNAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031167 rRNA methylation IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with RRNAD1: view

No data available for Pathways by source and SIGNOR curated interactions for RRNAD1 Gene

Transcripts for RRNAD1 Gene

Unigene Clusters for RRNAD1 Gene

Ribosomal RNA adenine dimethylase domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RRNAD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d · 11e ·
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - -
SP6: - - - - - -
SP7: - - - - -
SP9: - - - - - -
SP10: - -
SP11: - -

ExUns: 11f

Relevant External Links for RRNAD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RRNAD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RRNAD1 Gene

Protein differential expression in normal tissues from HIPED for RRNAD1 Gene

This gene is overexpressed in Bone marrow stromal cell (58.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RRNAD1 Gene

Protein tissue co-expression partners for RRNAD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RRNAD1 Gene:


SOURCE GeneReport for Unigene cluster for RRNAD1 Gene:

genes like me logo Genes that share expression patterns with RRNAD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RRNAD1 Gene

Orthologs for RRNAD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RRNAD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RRNAD1 34 35
  • 98.04 (n)
(Canis familiaris)
Mammalia C1ORF66 35
  • 91 (a)
  • 87.69 (n)
(Bos Taurus)
Mammalia RRNAD1 34 35
  • 90.46 (n)
(Mus musculus)
Mammalia Rrnad1 34 16 35
  • 85.89 (n)
(Rattus norvegicus)
Mammalia Rrnad1 34
  • 84.98 (n)
(Monodelphis domestica)
Mammalia RRNAD1 35
  • 74 (a)
(Gallus gallus)
Aves RRNAD1 34 35
  • 62.24 (n)
(Anolis carolinensis)
Reptilia RRNAD1 35
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rrnad1 34
  • 60.14 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25332 34
(Danio rerio)
Actinopterygii LOC100332368 34
  • 58.08 (n)
rrnad1 35 35
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2906 34 35
  • 45.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007607 34
  • 45.14 (n)
(Caenorhabditis elegans)
Secernentea F25H2.12 34 35
  • 41.11 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G16650 34
  • 39.97 (n)
(Oryza sativa)
Liliopsida Os12g0610500 34
  • 43.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
Species where no ortholog for RRNAD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRNAD1 Gene

Gene Tree for RRNAD1 (if available)
Gene Tree for RRNAD1 (if available)

Paralogs for RRNAD1 Gene

Paralogs for RRNAD1 Gene

genes like me logo Genes that share paralogs with RRNAD1: view

Variants for RRNAD1 Gene

Sequence variations from dbSNP and Humsavar for RRNAD1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10908517 -- 156,728,554(-) CTGGG(G/T)TCGGG upstream-variant-2KB, utr-variant-5-prime
rs10908518 -- 156,733,664(+) AGGTT(C/G)CCCTT intron-variant
rs111528072 -- 156,727,669(+) AAGGC(A/G)GAAGA upstream-variant-2KB, utr-variant-5-prime
rs111545639 -- 156,729,130(+) AGGCC(-/TC)TCTCA intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant, utr-variant-5-prime
rs111571171 -- 156,735,412(+) CAAAA(A/G)TACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RRNAD1 Gene

Variant ID Type Subtype PubMed ID
esv1475923 CNV insertion 17803354
esv2495964 CNV insertion 19546169
esv3326332 CNV duplication 20981092
esv3578200 CNV loss 25503493
nsv831648 CNV loss 17160897

Variation tolerance for RRNAD1 Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRNAD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRNAD1 Gene

Disorders for RRNAD1 Gene

Relevant External Links for RRNAD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RRNAD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRNAD1 Gene

Publications for RRNAD1 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64
  2. The relationship of alpha1-antitrypsin to inflammatory periodontal disease. (PMID: 310876) Peterson R.J. … Marsh C.L. (J. Periodontol. 1979) 2 3 64
  3. Discovery and refinement of loci associated with lipid levels. (PMID: 24097068) . … Abecasis G.R. (Nat. Genet. 2013) 3 64
  4. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J. … Lambert J.C. (Mol. Psychiatry 2009) 3 64
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64

Products for RRNAD1 Gene

Sources for RRNAD1 Gene

Loading form....