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Aliases for RRN3 Gene

Aliases for RRN3 Gene

  • RRN3 Homolog, RNA Polymerase I Transcription Factor 2 3 5
  • Transcription Initiation Factor IA 2 3 4
  • TIF-IA 3 4
  • TIFIA 3 4
  • RRN3 RNA Polymerase I Transcription Factor Homolog (S. Cerevisiae) 2
  • RRN3 RNA Polymerase I Transcription Factor Homolog (Yeast) 2
  • RRN3 RNA Polymerase I Transcription Factor Homolog 3
  • Transcription Initiation Factor TIF-IA 3
  • A-270G1.2 3

External Ids for RRN3 Gene

Previous GeneCards Identifiers for RRN3 Gene

  • GC16M016636
  • GC16P020093
  • GC16M015081
  • GC16M015120
  • GC16M015061
  • GC16M015153
  • GC16M014799

Summaries for RRN3 Gene

GeneCards Summary for RRN3 Gene

RRN3 (RRN3 Homolog, RNA Polymerase I Transcription Factor) is a Protein Coding gene. Among its related pathways are Gene Expression and mTOR signaling pathway. GO annotations related to this gene include binding and RNA polymerase binding.

UniProtKB/Swiss-Prot for RRN3 Gene

  • Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity).

Gene Wiki entry for RRN3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRN3 Gene

Genomics for RRN3 Gene

Regulatory Elements for RRN3 Gene

Promoters for RRN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RRN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RRN3 Gene

Chromosome:
16
Start:
15,060,022 bp from pter
End:
15,094,335 bp from pter
Size:
34,314 bases
Orientation:
Minus strand

Genomic View for RRN3 Gene

Genes around RRN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRN3 Gene

Proteins for RRN3 Gene

  • Protein details for RRN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYV6-RRN3_HUMAN
    Recommended name:
    RNA polymerase I-specific transcription initiation factor RRN3
    Protein Accession:
    Q9NYV6
    Secondary Accessions:
    • A2RTY9
    • B4E0J7
    • B4E3T2
    • Q3MHU9
    • Q6IPL4
    • Q9H4F0

    Protein attributes for RRN3 Gene

    Size:
    651 amino acids
    Molecular mass:
    74107 Da
    Quaternary structure:
    • Interacts with TWISTNB, EIF3L, TAF1B and TAF1C.

    Alternative splice isoforms for RRN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RRN3 Gene

Proteomics data for RRN3 Gene at MOPED

Post-translational modifications for RRN3 Gene

  • Phosphorylation is required for participation in rDNA transcription (By similarity). Phosphorylated at Thr-200 by MAPK9/JNK2, which abrogates initiation complex formation.
  • Ubiquitination at Lys 568
  • Modification sites at PhosphoSitePlus

Other Protein References for RRN3 Gene

Antibody Products

No data available for DME Specific Peptides for RRN3 Gene

Domains & Families for RRN3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYV6

UniProtKB/Swiss-Prot:

RRN3_HUMAN :
  • Belongs to the RRN3 family.
Family:
  • Belongs to the RRN3 family.
genes like me logo Genes that share domains with RRN3: view

No data available for Gene Families for RRN3 Gene

Function for RRN3 Gene

Molecular function for RRN3 Gene

UniProtKB/Swiss-Prot Function:
Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity).
genes like me logo Genes that share phenotypes with RRN3: view

Animal Models for RRN3 Gene

MGI Knock Outs for RRN3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RRN3 Gene

Localization for RRN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRN3 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RRN3 Gene COMPARTMENTS Subcellular localization image for RRN3 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for RRN3 Gene

Pathways & Interactions for RRN3 Gene

genes like me logo Genes that share pathways with RRN3: view

SIGNOR curated interactions for RRN3 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for RRN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006360 transcription from RNA polymerase I promoter TAS --
GO:0006361 transcription initiation from RNA polymerase I promoter TAS --
GO:0007000 nucleolus organization IEA --
GO:0008283 cell proliferation IEA --
GO:0010976 positive regulation of neuron projection development IEA --
genes like me logo Genes that share ontologies with RRN3: view

Drugs & Compounds for RRN3 Gene

No Compound Related Data Available

Transcripts for RRN3 Gene

Unigene Clusters for RRN3 Gene

RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RRN3 Gene

No ASD Table

Relevant External Links for RRN3 Gene

GeneLoc Exon Structure for
RRN3
ECgene alternative splicing isoforms for
RRN3

Expression for RRN3 Gene

mRNA expression in normal human tissues for RRN3 Gene

Protein differential expression in normal tissues from HIPED for RRN3 Gene

This gene is overexpressed in Bone (39.0) and Adrenal (30.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RRN3 Gene



SOURCE GeneReport for Unigene cluster for RRN3 Gene Hs.460078

genes like me logo Genes that share expression patterns with RRN3: view

Protein tissue co-expression partners for RRN3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RRN3 Gene

Orthologs for RRN3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RRN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RRN3 35
  • 88.87 (n)
  • 91.61 (a)
RRN3 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RRN3 35
  • 89.08 (n)
  • 91.77 (a)
RRN3 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rrn3 35
  • 86.28 (n)
  • 88.04 (a)
Rrn3 16
Rrn3 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RRN3 35
  • 99.58 (n)
  • 99.82 (a)
RRN3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rrn3 35
  • 85.97 (n)
  • 87.42 (a)
oppossum
(Monodelphis domestica)
Mammalia RRN3 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RRN3 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves RRN3 36
  • 70 (a)
OneToOne
RRN3 35
  • 74.06 (n)
  • 72.27 (a)
lizard
(Anolis carolinensis)
Reptilia RRN3 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rrn3 35
  • 68.8 (n)
  • 70.59 (a)
Str.15752 35
zebrafish
(Danio rerio)
Actinopterygii rrn3 35
  • 64.63 (n)
  • 64.01 (a)
rrn3 36
  • 61 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3554 35
fruit fly
(Drosophila melanogaster)
Insecta Tif-IA 37
  • 31 (a)
Tif-IA 35
  • 47.58 (n)
  • 34.46 (a)
Tif-IA 36
  • 29 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009024 35
  • 45.74 (n)
  • 35.47 (a)
worm
(Caenorhabditis elegans)
Secernentea C36E8.1 37
  • 24 (a)
C36E8.1 35
  • 45.47 (n)
  • 31.13 (a)
C36E8.1 36
  • 22 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRN3 38
RRN3 36
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G39240 35
  • 43.49 (n)
  • 32.89 (a)
rice
(Oryza sativa)
Liliopsida Os06g0688100 35
  • 44.68 (n)
  • 31.68 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09247 35
  • 42.1 (n)
  • 27.87 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rrn3 35
  • 44.25 (n)
  • 29.63 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2045 36
  • 37 (a)
OneToOne
Species with no ortholog for RRN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRN3 Gene

ENSEMBL:
Gene Tree for RRN3 (if available)
TreeFam:
Gene Tree for RRN3 (if available)

Paralogs for RRN3 Gene

(3) SIMAP similar genes for RRN3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RRN3: view

No data available for Paralogs for RRN3 Gene

Variants for RRN3 Gene

Sequence variations from dbSNP and Humsavar for RRN3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_051886 -

Structural Variations from Database of Genomic Variants (DGV) for RRN3 Gene

Variant ID Type Subtype PubMed ID
dgv811e1 CNV Complex 17122850
dgv812e1 CNV Complex 17122850
nsv511045 OTHER Complex 20534489
nsv7277 OTHER Inversion 18451855
dgv813e1 CNV Complex 17122850
nsv905361 CNV Gain 21882294
dgv814e1 CNV Complex 17122850
essv12354 CNV CNV 17122850
dgv2606n71 CNV Loss 21882294
dgv2607n71 CNV Gain 21882294
nsv905374 CNV Gain 21882294
dgv2608n71 CNV Loss 21882294
nsv905377 CNV Gain 21882294
nsv905380 CNV Gain 21882294
nsv509598 CNV Insertion 20534489
dgv344n27 CNV Loss 19166990
nsv457426 CNV Gain 19166990
dgv815e1 CNV Complex 17122850
esv270464 CNV Insertion 20981092
dgv2609n71 CNV Gain 21882294

Variation tolerance for RRN3 Gene

Residual Variation Intolerance Score: 84.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.91; 67.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRN3 Gene

HapMap Linkage Disequilibrium report
RRN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRN3 Gene

Disorders for RRN3 Gene

Relevant External Links for RRN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RRN3

No disorders were found for RRN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRN3 Gene

Publications for RRN3 Gene

  1. RNA polymerase I transcription factor Rrn3 is functionally conserved between yeast and human. (PMID: 10758157) Moorefield B. … Reeder R.H. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4 23 67
  2. ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth. (PMID: 12620228) Zhao J. … Grummt I. (Mol. Cell 2003) 3 23
  3. Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter. (PMID: 12393749) Yuan X. … Grummt I. (EMBO Rep. 2002) 3 23
  4. hRRN3 is essential in the SL1-mediated recruitment of RNA polymerase I to rRNA gene promoters. (PMID: 11250903) Miller G. … Zomerdijk J.C.B.M. (EMBO J. 2001) 2 3
  5. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3

Products for RRN3 Gene

Sources for RRN3 Gene

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