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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RRN3 Gene

protein-coding   GIFtS: 54
GCID: GC16M015153

RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)

(Previous name: RRN3 RNA polymerase I transcription factor homolog (yeast)...)
  Search for RRN3
in our new
 Human Malady Compendium 
Biological research products
for RRN3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
RRN3 RNA Polymerase I Transcription Factor Homolog (S. Cerevisiae)1 2     RRN3 RNA Polymerase I Transcription Factor Homolog (Yeast)1
TIFIA2 3 5     A-270G1.22
Transcription Initiation Factor IA2 3     RNA Polymerase I-Specific Transcription Initiation Factor RRN32
TIF-IA2 3     Transcription Initiation Factor TIF-IA2
DKFZp566E1041     

External Ids:    HGNC: 303461   Entrez Gene: 547002   Ensembl: ENSG000000857217   OMIM: 6051215   UniProtKB: Q9NYV63   

Export aliases for RRN3 gene to outside databases

Previous GC identifers: GC16M016636 GC16P020093 GC16M015081 GC16M015120 GC16M015061 GC16M014799


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RRN3_HUMAN, Q9NYV6
Function: Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the
competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot
activate transcription in a subsequent transcription reaction (By similarity)

Gene Wiki entry for RRN3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RRN3 gene promoter:
         AP-1   ATF-2   AP-4   HNF-1A   HNF-1   FOXO1a   c-Jun   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRRN3 promoter sequence
   Search SABiosciences Chromatin IP Primers for RRN3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RRN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12   Ensembl cytogenetic band:  16p13.11   HGNC cytogenetic band: 16p13.11

RRN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RRN3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M015153:  view genomic region     (about GC identifiers)

Start:
15,153,879 bp from pter      End:
15,188,174 bp from pter
Size:
34,296 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RRN3_HUMAN, Q9NYV6 (See protein sequence)
Recommended Name: RNA polymerase I-specific transcription initiation factor RRN3  
Size: 651 amino acids; 74107 Da
Subunit: Interacts with TWISTNB, EIF3L, TAF1B and TAF1C
Subcellular location: Nucleus, nucleolus
Secondary accessions: A2RTY9 Q6IPL4 Q9H4F0

Explore the universe of human proteins at neXtProt for RRN3: NX_Q9NYV6

Post-translational modifications:

  • Phosphorylation is required for participation in rDNA transcription (By similarity). Phosphorylated at Thr-200 by
  • MAPK9/JNK2, which abrogates initiation complex formation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NYV6

  • RRN3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060897.3  
    ENSEMBL proteins: 
     ENSP00000198767   ENSP00000454530   ENSP00000402027   ENSP00000318484   ENSP00000454238  
     ENSP00000437963  
    Reactome Protein details: Q9NYV6
    Human Recombinant Protein Products: 
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    Novus Biologicals RRN3 Proteins
    Novus Biologicals RRN3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RRN3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA--


    RRN3 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RRN3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007991 RNA_pol_I_trans_ini_fac_RRN3

    Graphical View of Domain Structure for InterPro Entry Q9NYV6

    ProtoNet protein and cluster: Q9NYV6

    1 Blocks protein family: IPB007991 RNA polymerase I specific transcription initiation factor RRN3

    UniProtKB/Swiss-Prot: RRN3_HUMAN, Q9NYV6
    Similarity: Belongs to the RRN3 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: RRN3_HUMAN, Q9NYV6
    Function: Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the
    competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot
    activate transcription in a subsequent transcription reaction (By similarity)

    miRNA
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    hsa-miR-3607-3p hsa-miR-300 hsa-miR-520d-5p hsa-miR-3942-5p hsa-miR-25 hsa-miR-92b hsa-miR-4308 hsa-miR-2114
    SwitchGear 3'UTR luciferase reporter plasmidRRN3 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RRN3

    Gene Editing
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003743translation initiation factor activity ----
    GO:0070063RNA polymerase binding IEA--


    RRN3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for RRN3:
     Nucleolar pre-40S maturation d 

    Animal Models:
         Mouse knock-out Rrn3tm1.2Igt for RRN3
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rrn3):
     cellular  embryogenesis  growth/size  mortality/aging  nervous system 

    RRN3 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1RNA Polymerase I Chain Elongation
    RNA Polymerase I Promoter Escape0.95
    RNA Polymerase I Promoter Clearance0.86
    RNA Polymerase I Transcription Initiation0.90
    RNA Polymerase I Transcription0.79
    2Transcription
    Transcription1.00
    3mTOR signaling pathway
    mTOR signaling pathway1.00
    4RNA Polymerase III Transcription Initiation
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.59
    5Generic Transcription Pathway
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for RRN3 
        mTOR signaling pathway

    5/7        Reactome Pathways for RRN3 (see all 7)
        RNA Polymerase I Transcription
    Transcription
    RNA Polymerase I Promoter Clearance
    RNA Polymerase I Promoter Escape
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription



    RRN3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RRN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/34 Interacting proteins for RRN3 (Q9NYV62, 3 ENSP000001987674) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLR1EQ9GZS12, 3, ENSP000003670294MINT-7264930 I2D: score=1 STRING: ENSP00000367029
    SETQ011052, 3, ENSP000003617774MINT-4544044 I2D: score=1 STRING: ENSP00000361777
    POLR1AO956022, 3, ENSP000002638574MINT-7264930 I2D: score=4 STRING: ENSP00000263857
    POLR1BQ9H9Y63, ENSP000002633314I2D: score=4 STRING: ENSP00000263331
    EIF3LQ9Y2623, ENSP000004168924I2D: score=2 STRING: ENSP00000416892
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0006352DNA-dependent transcription, initiation ----
    GO:0006360transcription from RNA polymerase I promoter TAS--
    GO:0006361transcription initiation from RNA polymerase I promoter TAS--
    GO:0007000nucleolus organization IEA--


    RRN3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RRN3
    Search CenterWatch for drugs/clinical trials and news about RRN3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RRN3 gene: 
    NM_018427.3  

    Unigene Cluster for RRN3:

    RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
    Hs.460078  [show with all ESTs]
    Unigene Representative Sequence: NM_018427
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000198767(uc010uzp.2 uc002dde.3 uc010uzq.2) ENST00000563559
    ENST00000429751 ENST00000327307 ENST00000561685 ENST00000564131(uc002ddf.1)
    ENST00000540462

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    hsa-miR-3607-3p hsa-miR-300 hsa-miR-520d-5p hsa-miR-3942-5p hsa-miR-25 hsa-miR-92b hsa-miR-4308 hsa-miR-2114
    SwitchGear 3'UTR luciferase reporter plasmidRRN3 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RRN3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RRN3

    Additional cDNA sequence: 

    AF227156.1 AJ272050.1 AK092795.1 AK225662.1 AK295486.1 AK300253.1 AK302994.1 AK303405.1 
    AK304856.1 AK314769.1 AK316520.1 AL110238.1 BC036182.1 BC071868.1 BC104660.1 BC132688.1 
    BC132690.1 

    14 DOTS entries:

    DT.446132  DT.102841357  DT.405646  DT.120692323  DT.102842028  DT.120692454  DT.120691873  DT.92453498 
    DT.120696043  DT.100682426  DT.120659039  DT.70103418  DT.92066759  DT.92453496 

    24/171 AceView cDNA sequences (see all 171):

    BQ638571 AA376316 BM564978 BP342141 BX282436 BC071868 AA089587 AA443853 
    AW193486 BX477835 AI582687 BM669552 BE549643 BE093077 AW239267 BX281597 
    AA481295 BE502966 AA910710 AA987540 CB148063 AW149757 CB266771 AW612846 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RRN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTAATCTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See RRN3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RRN3

    SOURCE GeneReport for Unigene cluster: Hs.460078
        SABiosciences Custom PCR Arrays for RRN3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RRN3 gene from 10/33 species (see all 33)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rrn31 , 5 RRN3 RNA polymerase I transcription factor homolog more1, 5 86.08(n)1
    87.83(a)1
      16 (9.59 cM)5
    1062981  NM_001039521.11  NP_001034610.11 
     137806995 
    chicken
    (Gallus gallus)
    Aves RRN31 RRN3 RNA polymerase I transcription factor homolog more 74.3(n)
    72.82(a)
      416414  XM_003642126.1  XP_003642174.1 
    lizard
    (Anolis carolinensis)
    Reptilia RRN36
    --
    65(a)
    1 ↔ 1
    GL343580.1(55391-76617)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480301052   -- 85.36(n)    48030105 
    zebrafish
    (Danio rerio)
    Actinopterygii rrn31 RRN3 RNA polymerase I transcription factor homolog more 64.68(n)
    64.01(a)
      558718  XM_701870.4  XP_706962.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tif-IA1 , 3 CG3278-PA1 31(a)3
    47.95(n)1
    35.35(a)1
      40F63
    354541  NM_176070.21  NP_788084.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C36E8.11 , 3 Protein C36E8.11 24(a)3
    43.91(n)1
    28.46(a)1
      III(4071462-4075697)3
    1755171  NM_065402.41  NP_497803.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RRN3(YKL125W)4
    RRN31
    Protein required for transcription of rDNA by RNA polymerase more4
    Rrn3p1
    42.75(n)1
    28.46(a)1
      11(208247-210130)4
    8537341, 4  NP_012797.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G347501 RNA polymerase I specific transcription initiation more 43.01(n)
    31.44(a)
      818040  NM_179905.3  NP_850236.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g06881001 hypothetical protein 45.36(n)
    31.96(a)
      4341897  NM_001064948.2  NP_001058413.2 


    ENSEMBL Gene Tree for RRN3 (if available)
    TreeFam Gene Tree for RRN3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RRN3 gene
    3 SIMAP similar genes for RRN3 using alignment to 6 protein entries:     RRN3_HUMAN (see all proteins):
    RRN3P1    A-270G1.2    RRN3P2

    RRN3 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for RRN3
    PGOHUM00000261200 PGOHUM00000262282 PGOHUM00000262316 PGOHUM00000262322 PGOHUM00000240969


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/581 NCBI SNPs in RRN3 are shown (see all 581    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs776497911,2
    C--14814775(+) AAAGA-/AAAG  
            
    AAAGA
    1 -- int11Minor allele frequency- AAAG:0.00CSA 2
    rs751867061,2
    --15153385(+) TTGCTC/GAACGT 1 -- int11Minor allele frequency- G:0.01NA 120
    rs29661281,2
    C,F,A,H,--15153389(-) TTTGAA/CGTTGA 1 -- int112Minor allele frequency- C:0.46NA WA CSA EA 377
    rs1907676091,2
    --15153568(+) TGTAAC/TTTATA 1 -- int10--------
    rs1807811771,2
    --15153571(+) AATTTA/TTAAGG 1 -- int10--------
    rs1861639541,2
    --15153651(+) TCCCTA/TGGACC 1 -- int10--------
    rs1431815461,2
    --15153708(+) GCGGAC/TACTTC 1 -- int10--------
    rs99278421,2
    C,F,A,H,--15153717(+) TCATAC/TAGTGC 1 -- int129Minor allele frequency- T:0.26NS EA NA WA CSA 2780
    rs113309371,2
    C--15153855(+) AAATT-/AAAAAA 1 -- int12Minor allele frequency- A:0.00NA CSA 4
    rs1124113081,2
    C,--15153874(+) AAAACA/GGAAAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for RRN3 (15153879 - 15188174 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for RRN3
         3 CNVs: 53132 3992 49656

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RRN3 for disorders           About MalaCards

    RRN3 for disorders           About GeneDecksing

    OMIM gene information: 605121    OMIM disorders: --


    Export disorders for RRN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RRN3 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with RRN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RNA polymerase I transcription factor Rrn3 is functionally conserved between yeast and human. (PubMed id 10758157)1, 2, 3, 9 Moorefield B.... Reeder R.H. (2000)
    2. hRRN3 is essential in the SL1-mediated recruitment of RNA polymerase I to rRNA gene promoters. (PubMed id 11250903)1, 2, 3 Miller G.... Zomerdijk J.C.B.M. (2001)
    3. Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter. (PubMed id 12393749)1, 2, 9 Yuan X.... Grummt I. (2002)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. TIF-IA, the factor mediating growth-dependent control of ribosomal RNA synthesis, is the mammalian homolog of yeast Rrn3p. (PubMed id 11265758)1, 2 Bodem J.... Grummt I. (2000)
    6. The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis. (PubMed id 15805466)2, 9 Mayer C....Grummt I. (2005)
    7. ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth. (PubMed id 12620228)1, 9 Zhao J....Grummt I. (2003)
    8. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Molecular basis of Rrn3-regulated RNA polymerase I in itiation and cell growth. (PubMed id 21940764)1 Blattner C....Cramer P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54700 HGNC: 30346 AceView: RRN3 Ensembl:ENSG00000085721 euGenes: HUgn54700
    ECgene: RRN3 H-InvDB: RRN3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RRN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RRN3 gene:
    Search GeneIP for patents involving RRN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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