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Aliases for RRM2 Gene

Aliases for RRM2 Gene

  • Ribonucleotide Reductase M2 2 3
  • Ribonucleotide Reductase M2 Polypeptide 2 3
  • Ribonucleotide Reductase Small Subunit 3 4
  • Ribonucleotide Reductase Small Chain 3 4
  • EC 1.17.4.1 4 63
  • RR2 3 4
  • RR2M 3
  • R2 3

External Ids for RRM2 Gene

Previous GeneCards Identifiers for RRM2 Gene

  • GC02P010047
  • GC02P010314
  • GC02P010267
  • GC02P010284
  • GC02P010213
  • GC02P010262

Summaries for RRM2 Gene

Entrez Gene Summary for RRM2 Gene

  • This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]

GeneCards Summary for RRM2 Gene

RRM2 (Ribonucleotide Reductase M2) is a Protein Coding gene. Diseases associated with RRM2 include pancreas adenocarcinoma and gestational trophoblastic neoplasm. Among its related pathways are Cell Cycle, Mitotic and Metabolism. GO annotations related to this gene include oxidoreductase activity and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. An important paralog of this gene is RRM2B.

UniProtKB/Swiss-Prot for RRM2 Gene

  • Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling

Gene Wiki entry for RRM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRM2 Gene

Genomics for RRM2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RRM2 Gene

Chromosome:
2
Start:
10,122,328 bp from pter
End:
10,131,419 bp from pter
Size:
9,092 bases
Orientation:
Plus strand

Genomic View for RRM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RRM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRM2 Gene

Proteins for RRM2 Gene

  • Protein details for RRM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31350-RIR2_HUMAN
    Recommended name:
    Ribonucleoside-diphosphate reductase subunit M2
    Protein Accession:
    P31350
    Secondary Accessions:
    • B2R9B5
    • J3KP43
    • Q5WRU7

    Protein attributes for RRM2 Gene

    Size:
    389 amino acids
    Molecular mass:
    44878 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 2 iron ions per subunit.;
    Quaternary structure:
    • Heterodimer of a large and a small subunit
    Miscellaneous:
    • Two distinct regulatory sites have been defined: the specificity site, which controls substrate specificity, and the activity site which regulates overall catalytic activity. A substrate-binding catalytic site, located on M1, is formed only in the presence of the second subunit M2
    SequenceCaution:
    • Sequence=DA477511; Type=Frameshift; Positions=87; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RRM2 Gene

    Alternative splice isoforms for RRM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RRM2 Gene

Proteomics data for RRM2 Gene at MOPED

Post-translational modifications for RRM2 Gene

  • Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling
  • Ubiquitination at Lys 23, Lys 61, Lys 217, and Lys 311
  • Modification sites at PhosphoSitePlus

Other Protein References for RRM2 Gene

Antibody Products

Domains & Families for RRM2 Gene

Protein Domains for RRM2 Gene

Suggested Antigen Peptide Sequences for RRM2 Gene

Graphical View of Domain Structure for InterPro Entry

P31350

UniProtKB/Swiss-Prot:

RIR2_HUMAN :
  • Belongs to the ribonucleoside diphosphate reductase small chain family.
Family:
  • Belongs to the ribonucleoside diphosphate reductase small chain family.
genes like me logo Genes that share domains with RRM2: view

No data available for Gene Families for RRM2 Gene

Function for RRM2 Gene

Molecular function for RRM2 Gene

GENATLAS Biochemistry:
ribonucleotide diphosphate reductase M2 polypeptide,pyrimidine biosynthetic pathway
UniProtKB/Swiss-Prot CatalyticActivity:
2-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin.
UniProtKB/Swiss-Prot Function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling

Enzyme Numbers (IUBMB) for RRM2 Gene

Gene Ontology (GO) - Molecular Function for RRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor NAS 1627826
GO:0005515 protein binding IPI 22632967
GO:0016491 oxidoreductase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RRM2: view
genes like me logo Genes that share phenotypes with RRM2: view

miRNA for RRM2 Gene

miRTarBase miRNAs that target RRM2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RRM2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for RRM2 Gene

Localization for RRM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRM2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RRM2 Gene COMPARTMENTS Subcellular localization image for RRM2 gene
Compartment Confidence
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for RRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005971 ribonucleoside-diphosphate reductase complex IBA --
genes like me logo Genes that share ontologies with RRM2: view

Pathways & Interactions for RRM2 Gene

genes like me logo Genes that share pathways with RRM2: view

UniProtKB/Swiss-Prot P31350-RIR2_HUMAN

  • Pathway: Genetic information processing; DNA replication

SIGNOR curated interactions for RRM2 Gene

Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for RRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006260 DNA replication IEA --
GO:0009186 deoxyribonucleoside diphosphate metabolic process IEA --
genes like me logo Genes that share ontologies with RRM2: view

Drugs & Compounds for RRM2 Gene

(27) Drugs for RRM2 Gene - From: NovoSeek, HMDB, DGIdb, DrugBank, ApexBio, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cladribine Approved, Investigational Pharma Target, inhibitor Apoptosis inducer in CLL cells 63
Gemcitabine Approved Pharma inhibitor, Biomarker Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1800
Hydroxyurea Approved Pharma inhibitor 181
Clofarabine Approved, Investigational Pharma inhibitor, binder Antimetabolite,inhibit DNA polymerase and ribonucleotide reductase 150
Gallium nitrate Approved, Investigational Pharma Target, inhibitor 6

(10) Additional Compounds for RRM2 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
dADP
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate
2793-06-8
dcdp
  • 2'-Deoxy-Cytidine 5'-pyrophosphate
  • 2'-Deoxy-Cytidine pyrophosphate
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • 2'-Deoxycytidine-5'-diphosphate
800-73-7
dGDP
  • 2'-Deoxy-GDP
  • 2'-Deoxyguanosine-5'-diphosphate
  • 5'-dGDP
  • Deoxyguanosine 5'-diphosphate
  • Deoxyguanosine diphosphate
3493-09-2
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with RRM2: view

Transcripts for RRM2 Gene

Unigene Clusters for RRM2 Gene

Ribonucleotide reductase M2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RRM2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RRM2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - -
SP2: - -
SP3: - -
SP4: -
SP5: - -

Relevant External Links for RRM2 Gene

GeneLoc Exon Structure for
RRM2
ECgene alternative splicing isoforms for
RRM2

Expression for RRM2 Gene

mRNA expression in normal human tissues for RRM2 Gene

mRNA differential expression in normal tissues according to GTEx for RRM2 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.6).

Protein differential expression in normal tissues from HIPED for RRM2 Gene

This gene is overexpressed in Ovary (53.3) and Breast (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RRM2 Gene



SOURCE GeneReport for Unigene cluster for RRM2 Gene Hs.226390

genes like me logo Genes that share expression patterns with RRM2: view

Protein tissue co-expression partners for RRM2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RRM2 Gene

Orthologs for RRM2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RRM2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RRM2 35
  • 91.43 (n)
  • 94.86 (a)
RRM2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RRM2 35
  • 91.52 (n)
  • 96.14 (a)
RRM2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rrm2 35
  • 88.17 (n)
  • 91.52 (a)
Rrm2 16
Rrm2 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RRM2 35
  • 96.44 (n)
  • 94.88 (a)
rat
(Rattus norvegicus)
Mammalia LOC100359539 35
  • 86.89 (n)
  • 90.23 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RRM2 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves RRM2 35
  • 79.67 (n)
  • 88.63 (a)
RRM2 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RRM2 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rrm2.2 35
  • 77.75 (n)
  • 84.42 (a)
African clawed frog
(Xenopus laevis)
Amphibia rrm2-prov 35
zebrafish
(Danio rerio)
Actinopterygii LOC100330864 35
  • 74.78 (n)
  • 84.46 (a)
rrm2 35
rrm2 36
  • 84 (a)
OneToMany
rrm2 36
  • 84 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12256 35
fruit fly
(Drosophila melanogaster)
Insecta RnrS 37
  • 81 (a)
RnrS 35
  • 70.52 (n)
  • 81.56 (a)
RnrS 36
  • 68 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006818 35
  • 70.62 (n)
  • 82.81 (a)
worm
(Caenorhabditis elegans)
Secernentea F19G12.2 37
  • 59 (a)
rnr-2 37
  • 70 (a)
rnr-2 35
  • 64.9 (n)
  • 70.09 (a)
F19G12.2 36
  • 10 (a)
ManyToMany
F54H12.2 36
  • 6 (a)
ManyToMany
F58F9.1 36
  • 13 (a)
ManyToMany
K09F6.5 36
  • 5 (a)
ManyToMany
rnr-2 36
  • 60 (a)
ManyToMany
Y57G11C.21 36
  • 9 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL136C 35
  • 67.18 (n)
  • 71.74 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F15103g 35
  • 64.18 (n)
  • 71.74 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RNR2 35
  • 64.39 (n)
  • 69.57 (a)
RNR2 36
  • 57 (a)
OneToMany
RNR2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons TSO2 35
  • 62.04 (n)
  • 70.37 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2712 35
rice
(Oryza sativa)
Liliopsida Os.9043 35
Os06g0127900 35
  • 62.48 (n)
  • 65.87 (a)
corn
(Zea mays)
Liliopsida Zm.5996 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4812 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07887 35
  • 65.96 (n)
  • 69.6 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes suc22 35
  • 64.69 (n)
  • 71.03 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2425 36
  • 70 (a)
OneToMany
Species with no ortholog for RRM2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRM2 Gene

ENSEMBL:
Gene Tree for RRM2 (if available)
TreeFam:
Gene Tree for RRM2 (if available)

Paralogs for RRM2 Gene

Paralogs for RRM2 Gene

(2) SIMAP similar genes for RRM2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RRM2 Gene

genes like me logo Genes that share paralogs with RRM2: view

Variants for RRM2 Gene

Sequence variations from dbSNP and Humsavar for RRM2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs15516 -- 10,129,354(+) CAACA(G/T)AGAAT reference, stop-gained
rs1130609 -- 10,122,793(+) GCGCC(G/T)CCACT utr-variant-5-prime, missense, reference
rs1138727 -- 10,130,802(+) ttttt(G/T)ttttt utr-variant-3-prime
rs1138728 -- 10,130,804(+) ttttt(A/T)ttttt utr-variant-3-prime
rs1138729 -- 10,131,069(+) TGTTT(A/G)TTGTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RRM2 Gene

Variant ID Type Subtype PubMed ID
nsv873633 CNV Loss 21882294

Variation tolerance for RRM2 Gene

Residual Variation Intolerance Score: 27.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRM2 Gene

HapMap Linkage Disequilibrium report
RRM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRM2 Gene

Disorders for RRM2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RRM2 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
pancreas adenocarcinoma
  • pancreatic adenocarcinoma
gestational trophoblastic neoplasm
  • hydatidiform mole, recurrent, 1
choriocarcinoma
  • chorioepithelioma
- elite association
Search RRM2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RRM2

Genetic Association Database (GAD)
RRM2
Human Genome Epidemiology (HuGE) Navigator
RRM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RRM2
genes like me logo Genes that share disorders with RRM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RRM2 Gene

Publications for RRM2 Gene

  1. Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase. (PMID: 20159953) Niida H. … Nakanishi M. (Genes Dev. 2010) 23 67
  2. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. (PMID: 20305636) Davis M.E. … Ribas A. (Nature 2010) 23 67
  3. Expression of nucleoside transporters, deoxycitidine kinase, ribonucleotide reductase regulatory subunits, and gemcitabine catabolic enzymes in primary ovarian cancer. (PMID: 19639316) Ferrandina G. … Del Tacca M. (Cancer Chemother. Pharmacol. 2010) 23 67
  4. Hepatitis B virus activates deoxynucleotide synthesis in nondividing hepatocytes by targeting the R2 gene. (PMID: 20155784) Cohen D. … Shaul Y. (Hepatology 2010) 23 67
  5. Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis. (PMID: 19250552) Zhang K. … Yen Y. (Mol. Cancer 2009) 23 67

Products for RRM2 Gene

  • Addgene plasmids for RRM2

Sources for RRM2 Gene

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