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Aliases for RRM1 Gene

Aliases for RRM1 Gene

  • Ribonucleotide Reductase Catalytic Subunit M1 2 3 5
  • Ribonucleoside-Diphosphate Reductase Subunit M1 3 4
  • Ribonucleotide Reductase M1 Polypeptide 2 3
  • EC 1.17.4.1 4 61
  • RR1 3 4
  • Ribonucleoside-Diphosphate Reductase Large Subunit 3
  • Ribonucleotide Reductase Large Subunit 4
  • Ribonucleotide Reductase, R1 Subunit 3
  • RIR1 3
  • R1 3

External Ids for RRM1 Gene

Previous GeneCards Identifiers for RRM1 Gene

  • GC11P004668
  • GC11P004381
  • GC11P004075
  • GC11P004080
  • GC11P004072
  • GC11P003849

Summaries for RRM1 Gene

Entrez Gene Summary for RRM1 Gene

  • This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for RRM1 Gene

RRM1 (Ribonucleotide Reductase Catalytic Subunit M1) is a Protein Coding gene. Diseases associated with RRM1 include Lung Papillary Adenocarcinoma and Granuloma Inguinale. Among its related pathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and Metabolism. GO annotations related to this gene include purine nucleotide binding and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor.

UniProtKB/Swiss-Prot for RRM1 Gene

  • Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Gene Wiki entry for RRM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRM1 Gene

Genomics for RRM1 Gene

Regulatory Elements for RRM1 Gene

Enhancers for RRM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F003900 1.3 Ensembl ENCODE 24.5 -190.1 -190061 8.6 HDGF PKNOX1 ATF1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SP5 STIM1 RRM1 MIR4687 ENSG00000229368 LOC105376527 ENSG00000230593 GC11P003897 GC11P003920
GH11F004093 1.1 ENCODE 27.6 +0.4 376 3.5 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 RRM1 TSSC2 OR7E12P FAM86GP LOC100506082 RRM1-AS1
GH11F003941 1.5 FANTOM5 Ensembl ENCODE 18.4 -145.5 -145488 14.7 PKNOX1 ARNT YY1 ZNF121 GATA2 KLF13 NCOA1 MIER2 REST TBX21 STIM1 RRM1 ENSG00000206976 MIR4687 ENSG00000229368 LOC105376527 RHOG ENSG00000255232 GC11P003932
GH11F004056 1.2 Ensembl ENCODE 22.1 -35.5 -35458 4.3 TBP PKNOX1 ARID4B THRB ZSCAN9 RARA ETV6 CREM MIXL1 THAP11 RRM1 ENSG00000206976 MIR4687 STIM1 ENSG00000229368 LOC105376527 RPS29P20
GH11F003875 1.6 FANTOM5 Ensembl ENCODE 15.4 -216.2 -216161 6.8 HDGF PKNOX1 ARNT ARID4B FEZF1 DMAP1 YY1 GATA2 JUNB NCOA1 STIM1 RHOG RRM1 ENSG00000229368 LOC105376527 MIR4687 ENSG00000206976 ENSG00000230593 NUP98 OR52B4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RRM1 on UCSC Golden Path with GeneCards custom track

Promoters for RRM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000557577 339 2201 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for RRM1 Gene

Chromosome:
11
Start:
4,094,561 bp from pter
End:
4,138,881 bp from pter
Size:
44,321 bases
Orientation:
Plus strand

Genomic View for RRM1 Gene

Genes around RRM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRM1 Gene

Proteins for RRM1 Gene

  • Protein details for RRM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23921-RIR1_HUMAN
    Recommended name:
    Ribonucleoside-diphosphate reductase large subunit
    Protein Accession:
    P23921
    Secondary Accessions:
    • Q9UNN2

    Protein attributes for RRM1 Gene

    Size:
    792 amino acids
    Molecular mass:
    90070 Da
    Quaternary structure:
    • Heterodimer of a large and a small subunit. Heterodimer with small subunit RRM2 or RRM2B. The heterodimer with RRM2 has higher catalytic activity than the heterodimer with RRM2B. Interacts with AHCYL1 which inhibits its activity.
    Miscellaneous:
    • The level of the enzyme activity is closely correlated with the growth rate of a cell and appears to vary with the cell cycle.
    • Two distinct regulatory sites have been defined: the specificity site, which controls substrate specificity, and the activity site which regulates overall catalytic activity. A substrate-binding catalytic site, located on M1, is formed only in the presence of the second subunit M2.

    Three dimensional structures from OCA and Proteopedia for RRM1 Gene

neXtProt entry for RRM1 Gene

Selected DME Specific Peptides for RRM1 Gene

P23921:
  • SNGLVPMLRV
  • GIYDTLKQCA
  • ETGTPYM
  • GPYETYEGSPVSKGILQYDMW
  • LNMDFVDP
  • YNYFGFKTLE
  • GLKTGMYY
  • PTLFNAGT
  • DDSIEGIYDTLK
  • IFETIYYGAL
  • SSCFLLSMK
  • IYLEPWH
  • SNLCTEI
  • IRATGSYI
  • KLCYGLN
  • NLNKIID
  • PMPTAST
  • RRVLSGEF
  • GVTTVELD
  • RHRPIGIGV
  • AVCNLAS
  • FLDLKKNTG
  • RGAFIDQSQS
  • KRDGRQE
  • ANPIQFTLNKEKLK
  • LYKDSCN
  • ERPQHMLMRV
  • FDKITSRI
  • QILGNNE
  • VMEDLYNY
  • LYKTVWEI
  • DMWNVTP
  • EPYTSNIY
  • ARYVDQGG
  • MVCSLEN
  • GEEFEKLY
  • LMCPNECPGL
  • ISKSAGGIG
  • LAARIAVSNLHK
  • GVQGLAD
  • IIYDRDF
  • LWIPDLFM
  • YIAGTNG
  • SMHFYGW
  • AEPNYGKLTS
  • QIFETIY
  • TLKQCALISK

Post-translational modifications for RRM1 Gene

  • Ubiquitination at Lys 24, Lys 70, Lys 92, Lys 111, Lys 128, Lys 149, Lys 158, Lys 180, Lys 243, Lys 376, Lys 414, Lys 465, Lys 471, Lys 479, Lys 643, Lys 656, Lys 681, Lys 689, Lys 693, Lys 719, Lys 729, Lys 733, and Lys 754
  • Modification sites at PhosphoSitePlus

Domains & Families for RRM1 Gene

Suggested Antigen Peptide Sequences for RRM1 Gene

Graphical View of Domain Structure for InterPro Entry

P23921

UniProtKB/Swiss-Prot:

RIR1_HUMAN :
  • Contains 1 ATP-cone domain.
  • Belongs to the ribonucleoside diphosphate reductase large chain family.
Domain:
  • Contains 1 ATP-cone domain.
Family:
  • Belongs to the ribonucleoside diphosphate reductase large chain family.
genes like me logo Genes that share domains with RRM1: view

No data available for Gene Families for RRM1 Gene

Function for RRM1 Gene

Molecular function for RRM1 Gene

GENATLAS Biochemistry:
ribonucleotide diphosphate reductase M1 polypeptide,pyrimidine biosynthetic pathway,putative metastasis suppressor (see TSG11D)
UniProtKB/Swiss-Prot CatalyticActivity:
2-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin.
UniProtKB/Swiss-Prot EnzymeRegulation:
Under complex allosteric control mediated by deoxynucleoside triphosphates and ATP binding to separate specificity and activation sites on the M1 subunit. The type of nucleotide bound at the specificity site determines substrate preference. It seems probable that ATP makes the enzyme reduce CDP and UDP, dGTP favors ADP reduction and dTTP favors GDP reduction. Stimulated by ATP and inhibited by dATP binding to the activity site, the dATP inhibition is mediated by AHCYL1 which stabilizes dATP in the site.
UniProtKB/Swiss-Prot Function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Enzyme Numbers (IUBMB) for RRM1 Gene

Gene Ontology (GO) - Molecular Function for RRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IEA,ISS --
GO:0005515 protein binding IPI 22632967
GO:0005524 ATP binding IEA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with RRM1: view
genes like me logo Genes that share phenotypes with RRM1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRM1 Gene

Localization for RRM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRM1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRM1 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
plasma membrane 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005971 ribonucleoside-diphosphate reductase complex IBA --
genes like me logo Genes that share ontologies with RRM1: view

Pathways & Interactions for RRM1 Gene

genes like me logo Genes that share pathways with RRM1: view

UniProtKB/Swiss-Prot P23921-RIR1_HUMAN

  • Pathway: Genetic information processing; DNA replication.

Gene Ontology (GO) - Biological Process for RRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IEA --
GO:0006206 pyrimidine nucleobase metabolic process IEA --
GO:0006260 DNA replication IEA --
GO:0008152 metabolic process IEA --
GO:0008584 male gonad development IEA --
genes like me logo Genes that share ontologies with RRM1: view

No data available for SIGNOR curated interactions for RRM1 Gene

Drugs & Compounds for RRM1 Gene

(51) Drugs for RRM1 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gemcitabine Approved Pharma inhibitor, Biomarker, Target Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1974
Clofarabine Approved, Investigational Pharma inhibitor, binder, Target Antimetabolite,inhibit DNA polymerase and ribonucleotide reductase 157
Hydroxyurea Approved Pharma inhibitor, Target 215
Cladribine Approved, Investigational Pharma Target, inhibitor Apoptosis inducer in CLL cells 71
Fludarabine Approved Pharma inhibitor, Target DNA synthsis inhibitor 1113,1113

(11) Additional Compounds for RRM1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dADP
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate
2793-06-8
dcdp
  • 2'-Deoxy-Cytidine 5'-pyrophosphate
  • 2'-Deoxy-Cytidine pyrophosphate
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • 2'-Deoxycytidine-5'-diphosphate
800-73-7
dGDP
  • 2'-Deoxy-GDP
  • 2'-Deoxyguanosine-5'-diphosphate
  • 5'-dGDP
  • Deoxyguanosine 5'-diphosphate
  • Deoxyguanosine diphosphate
3493-09-2
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0

(5) ApexBio Compounds for RRM1 Gene

Compound Action Cas Number
Clofarabine Antimetabolite,inhibit DNA polymerase and ribonucleotide reductase 123318-82-1
Fludarabine Phosphate (Fludara) Inhibits STAT1 activation and DNA synthesis 75607-67-9
Gemcitabine 95058-81-4
Hydroxyurea 127-07-1
Triapine Ribonucleotide reductase inhibitor 236392-56-6
genes like me logo Genes that share compounds with RRM1: view

Transcripts for RRM1 Gene

Unigene Clusters for RRM1 Gene

Ribonucleotide reductase M1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RRM1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - - -
SP2: - - -
SP3: -
SP4: -
SP5:

Relevant External Links for RRM1 Gene

GeneLoc Exon Structure for
RRM1
ECgene alternative splicing isoforms for
RRM1

Expression for RRM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RRM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RRM1 Gene

This gene is overexpressed in Lymph node (16.9), Fetal Brain (8.2), and Uterus (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RRM1 Gene



Protein tissue co-expression partners for RRM1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RRM1 Gene:

RRM1

SOURCE GeneReport for Unigene cluster for RRM1 Gene:

Hs.445705
genes like me logo Genes that share expression patterns with RRM1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RRM1 Gene

Orthologs for RRM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RRM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RRM1 34 35
  • 99.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RRM1 35
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RRM1 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RRM1 34 35
  • 92.79 (n)
dog
(Canis familiaris)
Mammalia RRM1 34 35
  • 92.68 (n)
rat
(Rattus norvegicus)
Mammalia Rrm1 34
  • 90.53 (n)
mouse
(Mus musculus)
Mammalia Rrm1 34 16 35
  • 90.11 (n)
chicken
(Gallus gallus)
Aves RRM1 34 35
  • 82.24 (n)
lizard
(Anolis carolinensis)
Reptilia RRM1 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rrm1 34
  • 78.2 (n)
Str.591 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.1365 34
zebrafish
(Danio rerio)
Actinopterygii rrm1 34 35
  • 76.47 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10214 34
fruit fly
(Drosophila melanogaster)
Insecta RnrL 36 34 35
  • 66.58 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010198 34
  • 65.82 (n)
worm
(Caenorhabditis elegans)
Secernentea rnr-1 36 34 35
  • 67.82 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C07887g 34
  • 65.38 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RNR1 34 37
  • 64.1 (n)
RNR3 35
  • 59 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL057W 34
  • 63.31 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RNR1 34
  • 64.23 (n)
rice
(Oryza sativa)
Liliopsida Os06g0168600 34
  • 64.23 (n)
Os.4222 34
barley
(Hordeum vulgare)
Liliopsida Hv.9033 34
wheat
(Triticum aestivum)
Liliopsida Ta.6274 34
corn
(Zea mays)
Liliopsida Zm.5173 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7111 35
  • 71 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU03539 34
  • 66.4 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdc22 34
  • 65.07 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2172 34
Species where no ortholog for RRM1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RRM1 Gene

ENSEMBL:
Gene Tree for RRM1 (if available)
TreeFam:
Gene Tree for RRM1 (if available)

Paralogs for RRM1 Gene

(5) SIMAP similar genes for RRM1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with RRM1: view

No data available for Paralogs for RRM1 Gene

Variants for RRM1 Gene

Sequence variations from dbSNP and Humsavar for RRM1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1015998 -- 4,129,639(+) TTTTT(A/G)TAGGC intron-variant
rs1036847 -- 4,105,210(-) GAAAA(C/T)TTATC intron-variant
rs1042812 -- 4,094,907(+) GAGCA(A/G)CGCCT utr-variant-5-prime
rs1042813 -- 4,094,968(+) AGAGC(C/G)GCAGT utr-variant-5-prime
rs1042858 -- 4,138,236(+) CCAGC(A/G)GCTAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for RRM1 Gene

Variant ID Type Subtype PubMed ID
nsv8777 CNV gain+loss 18304495
nsv832053 CNV gain 17160897
nsv428248 CNV gain+loss 18775914
nsv1070004 CNV deletion 25765185
nsv1053482 CNV gain 25217958
nsv1053189 CNV gain 25217958
esv3578116 CNV gain 25503493
esv2759797 CNV gain+loss 17122850
esv1431944 CNV insertion 17803354

Variation tolerance for RRM1 Gene

Residual Variation Intolerance Score: 13.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRM1 Gene

Human Gene Mutation Database (HGMD)
RRM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RRM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRM1 Gene

Disorders for RRM1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for RRM1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung papillary adenocarcinoma
  • papillary adenocarcinoma of the lung
granuloma inguinale
  • donovanosis
brachial plexus neuritis
  • brachial neuritis
autosomal dominant progressive external ophthalmoplegia
  • adpeo
adenosquamous pancreas carcinoma
  • adenosquamous carcinoma of pancreas
- elite association - COSMIC cancer census association via MalaCards
Search RRM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RRM1

Genetic Association Database (GAD)
RRM1
Human Genome Epidemiology (HuGE) Navigator
RRM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RRM1
genes like me logo Genes that share disorders with RRM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RRM1 Gene

Publications for RRM1 Gene

  1. Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity. (PMID: 20028759) Okazaki T. … Li D. (Clin. Cancer Res. 2010) 3 22 46 64
  2. RRM1 single nucleotide polymorphism -37C-->A correlates with progression-free survival in NSCLC patients after gemcitabine-based chemotherapy. (PMID: 20226083) Dong S. … Wu Y.L. (J Hematol Oncol 2010) 3 22 46 64
  3. Polymorphisms of the ribonucleotide reductase M1 gene and sensitivity to platin-based chemotherapy in non-small cell lung cancer. (PMID: 19304340) Feng J.F. … Chen B.A. (Lung Cancer 2009) 3 22 46 64
  4. Efficacy of gemcitabine in patients with non-small cell lung cancer according to promoter polymorphisms of the ribonucleotide reductase M1 gene. (PMID: 18483375) Kim S.O. … Kim Y.C. (Clin. Cancer Res. 2008) 3 22 46 64
  5. Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer. (PMID: 17131328) Nakahira S. … Monden M. (Int. J. Cancer 2007) 3 22 25 64

Products for RRM1 Gene

Sources for RRM1 Gene

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