Aliases for RRM1 Gene
External Ids for RRM1 Gene
Previous GeneCards Identifiers for RRM1 Gene
This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. [provided by RefSeq, Jul 2008]
GeneCards Summary for RRM1 Gene
RRM1 (Ribonucleotide Reductase M1) is a Protein Coding gene. Diseases associated with RRM1 include beckwith-wiedemann syndrome and wilms tumor. Among its related pathways are Integrated Pancreatic Cancer Pathway and Cell Cycle / Checkpoint Control. GO annotations related to this gene include ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor.
UniProtKB/Swiss-Prot for RRM1 Gene
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides