Aliases for RRM1 Gene
External Ids for RRM1 Gene
Previous GeneCards Identifiers for RRM1 Gene
This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. [provided by RefSeq, Jul 2008]
GeneCards Summary for RRM1 Gene
RRM1 (Ribonucleotide Reductase M1) is a Protein Coding gene. Diseases associated with RRM1 include lung papillary adenocarcinoma and adenosquamous pancreas carcinoma. Among its related pathways are Integrated Pancreatic Cancer Pathway and Metabolism. GO annotations related to this gene include purine nucleotide binding and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor.
UniProtKB/Swiss-Prot for RRM1 Gene
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides