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RRM1 Gene

protein-coding   GIFtS: 74
GCID: GC11P004115

Ribonucleotide Reductase M1

(Previous name: ribonucleotide reductase M1 polypeptide)
  See RRM1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribonucleotide Reductase M11 2     R12
Ribonucleotide Reductase M1 Polypeptide1 2     RIR12
Ribonucleoside-Diphosphate Reductase Subunit M12 3     Ribonucleoside-Diphosphate Reductase Large Subunit2
RR12 3     Ribonucleotide Reductase, R1 Subunit2
EC 1.17.4.13 8     Ribonucleotide Reductase Large Subunit3

External Ids:    HGNC: 104511   Entrez Gene: 62402   Ensembl: ENSG000001673257   OMIM: 1804105   UniProtKB: P239213   

Export aliases for RRM1 gene to outside databases

Previous GC identifers: GC11P004668 GC11P004381 GC11P004075 GC11P004080 GC11P004072 GC11P003849


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RRM1 Gene:
This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an
enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells.
It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene
region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor,
rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in
malignancies and disease that involve this region. (provided by RefSeq, Jul 2008)

GeneCards Summary for RRM1 Gene:
RRM1 (ribonucleotide reductase M1) is a protein-coding gene. Diseases associated with RRM1 include wilms tumor, and beckwith-wiedemann syndrome. GO annotations related to this gene include ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor.

UniProtKB/Swiss-Prot: RIR1_HUMAN, P23921
Function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides
from the corresponding ribonucleotides

Gene Wiki entry for RRM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the RRM1 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F   E2F-1   p53   HOXA5   Lmo2   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRRM1 promoter sequence
   Search Chromatin IP Primers for RRM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RRM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.5

RRM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RRM1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P004115:  view genomic region     (about GC identifiers)

Start:
4,115,924 bp from pter      End:
4,160,106 bp from pter
Size:
44,183 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RIR1_HUMAN, P23921 (See protein sequence)
Recommended Name: Ribonucleoside-diphosphate reductase large subunit  
Size: 792 amino acids; 90070 Da
Subunit: Heterodimer of a large and a small subunit. Heterodimer with small subunit RRM2 or RRM2B. The heterodimer
with RRM2 has higher catalytic activity than the heterodimer with RRM2B
Miscellaneous: Two distinct regulatory sites have been defined: the specificity site, which controls substrate
specificity, and the activity site which regulates overall catalytic activity. A substrate-binding catalytic
site, located on M1, is formed only in the presence of the second subunit M2
Miscellaneous: The level of the enzyme activity is closely correlated with the growth rate of a cell and appears
to vary with the cell cycle
5 PDB 3D structures from and Proteopedia for RRM1:
2WGH (3D)        3HNC (3D)        3HND (3D)        3HNE (3D)        3HNF (3D)    
Secondary accessions: Q9UNN2

Explore the universe of human proteins at neXtProt for RRM1: NX_P23921

Explore proteomics data for RRM1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys24, Lys70, Lys92, Lys111, Lys128, Lys149, Lys158, Lys180, Lys243, Lys376,
                                 Lys414, Lys465, Lys471, Lys479, Lys496, Lys643, Lys656, Lys681, Lys689, Lys693 (see all 24)
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for RRM1 (P23921) (see all 47)
     LYKDSCN  ETGTPYM  QILGNNE  DMWNVTP 


    See RRM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001024.1  
    ENSEMBL proteins: 
     ENSP00000435656   ENSP00000300738   ENSP00000434069   ENSP00000432555   ENSP00000431464  
     ENSP00000436377   ENSP00000390539   ENSP00000442148  
    Reactome Protein details: P23921

    RRM1 Human Recombinant Protein Products:

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    Novus Biologicals RRM1 Proteins
    Novus Biologicals RRM1 Lysate
    Sino Biological Recombinant Protein for RRM1
    Sino Biological Cell Lysate for RRM1
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    Cloud-Clone Corp. Proteins for RRM1

     
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    RRM1 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RRM1
    Cloud-Clone Corp. CLIAs for RRM1
    Search eBioscience for ELISAs for RRM1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR013346 NrdE_NrdA
     IPR013509 RNR_lsu_N
     IPR005144 ATP-cone
     IPR000788 RNR_lg_C
     IPR008926 RNR_R1-su_N

    Graphical View of Domain Structure for InterPro Entry P23921

    ProtoNet protein and cluster: P23921

    2 Blocks protein domains:
    IPB000788 Ribonucleotide reductase large subunit
    IPB005144 ATP cone domain


    UniProtKB/Swiss-Prot: RIR1_HUMAN, P23921
    Similarity: Belongs to the ribonucleoside diphosphate reductase large chain family
    Similarity: Contains 1 ATP-cone domain


    Find genes that share domains with RRM1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RIR1_HUMAN, P23921
    Function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides
    from the corresponding ribonucleotides
    Catalytic activity: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside
    diphosphate + thioredoxin
    Enzyme regulation: Under complex allosteric control mediated by deoxynucleoside triphosphates and ATP binding to
    separate specificity and activation sites on the M1 subunit. The type of nucleotide bound at the specificity site
    determines substrate preference. It seems probable that ATP makes the enzyme reduce CDP and UDP, dGTP favors ADP
    reduction and dTTP favors GDP reduction. Stimulated by ATP and inhibited by dATP binding to the activity site

         Genatlas biochemistry entry for RRM1:
    ribonucleotide diphosphate reductase M1 polypeptide,pyrimidine biosynthetic pathway,putative metastasis suppressor
    (see TSG11D)

         Enzyme Number (IUBMB): EC 1.17.4.11 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004748ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ISS--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0017076purine nucleotide binding ----
         
    Find genes that share ontologies with RRM1           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for RRM1:
     Decreased cell number and incr  Increased S DNA content  Increased cell number in S  Increased gamma-H2AX phosphory 
     S arrest  Synthetic lethal with Ras  Synthetic lethal with gemcitab 

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RRM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RRM1

    miRNA
    Products:
        
    miRTarBase miRNAs that target RRM1:
    hsa-mir-877-3p (MIRT037088), hsa-mir-92a-3p (MIRT049472), hsa-let-7i-5p (MIRT046549), hsa-mir-1 (MIRT023637), hsa-mir-192-5p (MIRT004159)

    Block miRNA regulation of human, mouse, rat RRM1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate RRM1:
    hsa-miR-4328 hsa-miR-205* hsa-miR-545 hsa-miR-551b* hsa-miR-338-3p
    SwitchGear 3'UTR luciferase reporter plasmidRRM1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat RRM1

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for RRM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RRM1 (NM_001033)
    Sino Biological Human cDNA Clone for RRM1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RRM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRM1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RIR1_HUMAN, P23921: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    plasma membrane3

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IEA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005971ribonucleoside-diphosphate reductase complex IEA--

    Find genes that share ontologies with RRM1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RRM1 About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Purine metabolism (KEGG)
    Purine metabolism0.38
    ATP ITP metabolism0.31
    Pyrimidine metabolism0.38
    2Pyrimidine metabolism
    Fluoropyrimidine Activity0.69
    Fluoropyrimidine Pathway, Pharmacokinetics0.69
    3Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    4superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis0.52
    pyrimidine deoxyribonucleotides biosynthesis from CTP0.00
    guanosine deoxyribonucleotides de novo biosynthesis0.52
    adenosine deoxyribonucleotides de novo biosynthesis0.00
    pyrimidine deoxyribonucleotides de novo biosynthesis0.00
    5purine nucleotide salvage
    purine nucleotide salvage0.78
    guanosine nucleotides de novo biosynthesis0.00
    purine nucleotides de novo biosynthesis0.78


    Find genes that share SuperPaths with RRM1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for RRM1
        Cell Cycle / Checkpoint Control
    DNA Damage

    1 GeneGo (Thomson Reuters) Pathway for RRM1
        ATP/ITP metabolism

    Selected BioSystems Pathways for RRM1 (see all 13)
        Fluoropyrimidine Activity
    purine nucleotides de novo biosynthesis
    Nucleotide Metabolism
    Integrated Pancreatic Cancer Pathway
    guanosine nucleotides de novo biosynthesis


    1 Reactome Pathway for RRM1
        Synthesis and interconversion of nucleotide di- and triphosphates

    2 PharmGKB Pathways for RRM1
        Fluoropyrimidine Pathway, Pharmacokinetics
    Gemcitabine Pathway, Pharmacodynamics

    4 Kegg Pathways  (Kegg details for RRM1):
        Purine metabolism
    Pyrimidine metabolism
    Glutathione metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: RIR1_HUMAN, P23921
    Pathway: Genetic information processing; DNA replication

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RRM1
    Interactions:

        GeneGlobe Interaction Network for RRM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RRM1 (P239211, 2, 3 ENSP000003007384) via UniProtKB, MINT, STRING, and/or I2D (see all 219)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    LRIF1Q5T3J32, 3MINT-63606 I2D: score=4 
    ENSG00000172850Q9Y3333I2D: score=3 
    ENSG00000224979Q9Y3333I2D: score=3 
    ENSG00000225998Q9Y3333I2D: score=3 
    ENSG00000231502Q9Y3333I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle IEA--
    GO:0006206pyrimidine nucleobase metabolic process IEA--
    GO:0006260DNA replication IEA--
    GO:0008584male gonad development IEA--
    GO:0009263deoxyribonucleotide biosynthetic process ISS--

    Find genes that share ontologies with RRM1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RRM1 (RIR1)

    9 HMDB Compounds for RRM1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CDPCDP (see all 3)63-38-7--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    IronArmco iron (see all 19)7439-89-6--
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    dADP2'-deoxyadenosine-5'-diphosphate (see all 3)2793-06-8--
    dCDP2'-Deoxycytidine 5'-diphosphate (see all 13)800-73-7--

    5 DrugBank Compounds for RRM1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Clofarabine-- 123318-82-1targetinhibitor18728851 19576186 19519505 18780321 17139284 17016423 15230627 20631817 17852710
    GemcitabinedFdC (see all 4)95058-81-4targetinhibitor17131328 16966686 17636467 16708051 17065054 16807441
    Cladribine2-CdA (see all 5)4291-63-8targetinhibitor19576186 19715446 16316309 17852710 9923554
    FludarabineFAMP (see all 4)75607-67-9targetinhibitor19325518 19519505 17139284 17016423
    HydroxyureaCarbamohydroxamic Acid (see all 13)127-07-1targetinhibitor20462199 14583450 15075397 20005847

    Selected Novoseek inferred chemical compound relationships for RRM1 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gemcitabine 85.8 144 20021860 (9), 17131328 (6), 20226083 (6), 18636187 (6) (see all 37)
    deoxycytidine 74.6 12 16585222 (1), 20211060 (1), 16708051 (1), 17224927 (1) (see all 8)
    deoxyribonucleotide 74 1 14645917 (1)
    cisplatin 53.9 26 14977831 (2), 12789263 (2), 18494946 (2), 15277258 (2) (see all 14)
    carboplatin 42.3 6 19884554 (2), 18494946 (2), 16966686 (1), 12789263 (1)
    nucleoside 42.1 5 16585222 (1), 17224927 (1), 19531250 (1), 19842938 (1)
    dichloromethane 37.3 7 16708051 (1), 17602053 (1), 19842938 (1), 12938148 (1)
    12-o-tetradecanoylphorbol 13-acetate 37 13 8404864 (6), 7553616 (1)
    docetaxel 35.2 5 18414411 (3), 19002265 (2)
    paclitaxel 27.6 5 12789263 (1), 17229776 (1)

    3 PharmGKB related drug/compound annotations for RRM1 gene    About this table
    Drug/compound PharmGKB Annotation
    cladribineCA  
    cytarabineCA  
    gemcitabineCA  



    Find genes that share compounds with RRM1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RRM1 gene: 
    NM_001033.3  

    Unigene Cluster for RRM1:

    Ribonucleotide reductase M1
    Hs.445705  [show with all ESTs]
    Unigene Representative Sequence: NM_001033
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000532710 ENST00000532170(uc009yeh.1 uc001lyw.4 uc009yei.3 uc010qyc.2)
    ENST00000526865 ENST00000300738 ENST00000533349 ENST00000526350 ENST00000530368
    ENST00000528442 ENST00000534285(uc009yej.2) ENST00000533495 ENST00000526304
    ENST00000528470 ENST00000531591 ENST00000529109 ENST00000423050 ENST00000537197(uc010qyd.2)

    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate RRM1:
    hsa-miR-4328 hsa-miR-205* hsa-miR-545 hsa-miR-551b* hsa-miR-338-3p
    SwitchGear 3'UTR luciferase reporter plasmidRRM1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RRM1
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    GenScript: all cDNA clones in your preferred vector: RRM1 (NM_001033)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RRM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRM1
    Primer
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    OriGene qPCR primer pairs and template standards for RRM1
    OriGene qSTAR qPCR primer pairs in human, mouse for RRM1
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      QuantiTect SYBR Green Assays in human, mouse, rat RRM1
      QuantiFast Probe-based Assays in human, mouse, rat RRM1

    Additional mRNA sequence: 

    AK222786.1 AK297988.1 AK299629.1 AK301891.1 AK301922.1 AK303394.1 AK307950.1 AK311593.1 
    BC006498.2 NR_047550.1 X59543.1 X59617.1 

    20 DOTS entries:

    DT.100655940  DT.92457344  DT.87017494  DT.100726630  DT.100720169  DT.101984045  DT.120740357  DT.120740371 
    DT.410686  DT.100655943  DT.120740327  DT.100655945  DT.95239132  DT.120740375  DT.92457326  DT.100655946 
    DT.120740319  DT.70102375  DT.92043419  DT.95239140 

    Selected AceView cDNA sequences (see all 616):

    BQ929576 BM555769 BP354299 BM835237 CA489679 BM834002 BE502572 BM827830 
    BQ050574 BP373256 BU192332 CR622023 BQ933597 BQ278938 BP363632 BI226308 
    BQ230367 AV714076 BU187289 BP336776 BP356165 BX460262 BP356784 AU280564 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RRM1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                                      -                             -                 -                 -                                                   
    SP2:                          -           -                             -                                                                                       
    SP3:                                                                    -                                                                                       
    SP4:                                                                                      -                                                                     
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for RRM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    RRM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAGTACTG
    RRM1 Expression
    About this image


    RRM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Double Negative 2 Thymocytes Thymus
             Thymus
     
     Kidney (Urinary System)
             Metanephros
     
     Lung (Respiratory System)
             Trachea
    RRM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RRM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445705
        Custom PCR Arrays for RRM1
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RRM1 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rrm11 , 5 ribonucleotide reductase M11, 5 90.11(n)1
    97.6(a)1
      7 (54.72 cM)5
    201331  NM_009103.31  NP_033129.21 
     1024416955 
    chicken
    (Gallus gallus)
    Aves RRM11 ribonucleotide reductase M1 82.24(n)
    94.05(a)
      419081  NM_001030837.1  NP_001026008.1 
    lizard
    (Anolis carolinensis)
    Reptilia RRM16
    ribonucleotide reductase M1
    89(a)
    1 ↔ 1
    GL343693.1(158724-195342)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.13652 Xenopus laevis ribonucleotide reductase subunit M1 more 80.13(n)    BC046846.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rrm12 ribonucleotide reductase protein r1 class I 77.88(n)   30740  NM_131455.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RnrL1 , 3 DNA replication
    ribonucleoside-diphosphate reductase3
    Ribonucleoside diphosphate reductase large subunit1
    74(a)3
    66.58(n)1
    75(a)1
      31D83
    343921  NM_057679.51  NP_477027.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rnr-11 , 3 Ribonucleoside-disphosphate reductase
    large chain3
    rnr-11
    73(a)3
    67.82(n)1
    75.06(a)1
      III(9297244-9299971)3
    1763011  NM_066638.41  NP_499039.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RNR1(YER070W)4
    RNR11
    Major isoform of the large subunit of ribonucleotide-diphosphate more4
    RNR11
    64.1(n)1
    67.64(a)1
      5(298950-301616)4
    8568011, 4  NP_010993.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RNR11 RNR1 64.23(n)
    69.19(a)
      816715  NM_127748.3  NP_179770.1 
    rice
    (Oryza sativa)
    Liliopsida Os.42222 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.16(n)    AK068858.1 


    ENSEMBL Gene Tree for RRM1 (if available)
    TreeFam Gene Tree for RRM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RRM1 gene
    5 SIMAP similar genes for RRM1 using alignment to 8 protein entries:     RIR1_HUMAN (see all proteins):
    CEP95    CADM1    TUBA1C    NELFA    ABI2

    Find genes that share paralogs with RRM1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RRM1 (see all 1099)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs344746171,2
    C--3853096(+) CTGCT-/AATATT 1 -- int11Minor allele frequency- A:0.00NA 2
    rs345460281,2
    C,F--3855317(+) TGTGA-/TTTTTT 1 -- int13Minor allele frequency- T:0.33NA CSA 6
    rs1112578981,2
    C--3856212(+) CCCCCA/-CCCCG 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs57893231,2
    C,F--3884155(+) ATATG-/AAAAAA 1 -- int1 trp33Minor allele frequency- A:0.33NA CSA 6
    rs2008079721,2
    C--3884608(+) CTGTA-/A/TT  
            
    TATAT
    1 -- int10--------
    rs79476051,2
    C--3884609(+) TGTATA/TTATAT 1 -- int10--------
    rs1996049721,2
    --3891322(+) TTTTC-/TTTT  
            
    TATTT
    1 -- int10--------
    rs1894764131,2
    --4039485(+) CCTTTC/TAAAAG 1 -- int10--------
    rs1825871871,2
    --4039523(+) GACTGC/TGTACG 1 -- int10--------
    rs17350531,2
    C,F,H--4039637(+) AATACA/GGTTTG 1 -- int118Minor allele frequency- G:0.14MN NS EA NA WA CSA 977

    HapMap Linkage Disequilibrium report for RRM1 (4115924 - 4160106 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RRM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1431944CNV Insertion17803354
    nsv896896CNV Gain21882294
    nsv832053CNV Gain17160897
    nsv8777CNV Gain+Loss18304495
    nsv428248CNV Gain+Loss18775914
    essv17026CNV CNV17122850

    Human Gene Mutation Database (HGMD): RRM1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RRM1
    DNA2.0 Custom Variant and Variant Library Synthesis for RRM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 180410    OMIM disorders: --

    4 diseases for RRM1:    
    About MalaCards
    wilms tumor    beckwith-wiedemann syndrome    pancreatic cancer    breast cancer

    1 disease from the University of Copenhagen DISEASES database for RRM1:
    Lung cancer

    Find genes that share disorders with RRM1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for RRM1 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nsclc 73.5 34 20226083 (3), 16980606 (3), 20211060 (2), 17602079 (2) (see all 16)
    cancer lung 61 28 16966686 (3), 17314339 (3), 18494946 (3), 19884554 (2) (see all 16)
    xeroderma pigmentosum 59.4 8 16539210 (1), 15277258 (1), 19289372 (1)
    pancreatic cancer 51.4 6 17131328 (2), 19543324 (2), 19968494 (1), 18751396 (1)
    tumors 36.6 44 19488864 (4), 17314339 (4), 15143080 (4), 10441745 (3) (see all 23)
    herpes simplex 34 3 9634800 (1), 14715543 (1), 2167936 (1)
    cancer 13.8 7 16708051 (1), 17907961 (1), 19452042 (1), 14555530 (1) (see all 5)
    metastasis 4.16 4 12687015 (2), 9933563 (1), 15639717 (1)
    colon cancer 0 2 14555530 (1), 11385363 (1)
    breast cancer 0 25 17602053 (4), 12938148 (2), 17229776 (1), 19289372 (1)

    Genetic Association Database (GAD): RRM1
    Human Genome Epidemiology (HuGE) Navigator: RRM1 (17 documents)

    Export disorders for RRM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RRM1 gene, integrated from 10 sources (see all 194):
    (articles sorted by number of sources associating them with RRM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RRM1 single nucleotide polymorphism -37C--&gt;A correlates with progression-free survival in NSCLC patients after gemcitabine-based chemotherapy. (PubMed id 20226083)1, 4, 9 Dong S....Wu Y.L. (amp 2010)
    2. Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer. (PubMed id 17131328)1, 7, 9 Nakahira S....Monden M. (Int. J. Cancer 2007)
    3. An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients. (PubMed id 17602053)1, 4, 9 Rha S.Y....Chung H.C. (Oncologist 2007)
    4. RRM1 modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small-cell lung cancer. (PubMed id 16966686)1, 7, 9 Bepler G....Simon G. (J. Clin. Oncol. 2006)
    5. Human R1 subunit of ribonucleotide reductase (RRM1): 5' flanking region of the gene. (PubMed id 8188248)1, 2, 9 Parker N.J.... Fox R.M. (Genomics 1994)
    6. Polymorphisms of the ribonucleotide reductase M1 gene and sensitivity to platin-based chemotherapy in non-small cell lung cancer. (PubMed id 19304340)1, 4, 9 Feng J.F....Chen B.A. (Lung Cancer 2009)
    7. Efficacy of gemcitabine in patients with non-small cell lung cancer according to promoter polymorphisms of the ribonucleotide reductase M1 gene. (PubMed id 18483375)1, 4, 9 Kim S.O....Kim Y.C. (Clin. Cancer Res. 2008)
    8. Human gene for the large subunit of ribonucleotide reductase (RRM1): functional analysis of the promoter. (PubMed id 7557993)1, 3, 9 Parker N.J....Fox R.M. (Genomics 1995)
    9. Single nucleotide polymorphisms and outcome in docetaxel-cisplatin-treated advanced non-small-cell lung cancer. (PubMed id 15277258)1, 4, 9 Isla D....Lianes P. (Ann. Oncol. 2004)
    10. A 1.4-Mb high-resolution physical map and contig of chromosome segment 11p15.5 and genes in the LOH11A metastasis suppressor region. (PubMed id 9933563)1, 2, 9 Bepler G.... Pitterle D.M. (Genomics 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6240 HGNC: 10451 AceView: RRM1 Ensembl:ENSG00000167325 euGenes: HUgn6240
    ECgene: RRM1 Kegg: 6240 H-InvDB: RRM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RRM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RRM1 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Ribonucleotide_reductase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RRM1 gene:
    Search GeneIP for patents involving RRM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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