Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RRH Gene

protein-coding   GIFtS: 57
GCID: GC04P110749

Retinal Pigment Epithelium-Derived Rhodopsin Homolog

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Retinal Pigment Epithelium-Derived Rhodopsin Homolog1 2
peropsin1 2
Visual Pigment-Like Receptor Peropsin2

External Ids:    HGNC: 104501   Entrez Gene: 106922   Ensembl: ENSG000001802457   OMIM: 6052245   UniProtKB: O147183   

Export aliases for RRH gene to outside databases

Previous GC identifers: GC04U990073 GC04P111019 GC04P111142 GC04P111207 GC04P111106 GC04P110968 GC04P106481


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RRH Gene:
Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene
belongs to the seven-exon subfamily of mammalian opsin genes that includes opsin 5 and retinal G protein coupled
receptor. (provided by RefSeq, Jul 2008)

GeneCards Summary for RRH Gene:
RRH (retinal pigment epithelium-derived rhodopsin homolog) is a protein-coding gene. GO annotations related to this gene include photoreceptor activity and G-protein coupled receptor activity. An important paralog of this gene is OPN3.

UniProtKB/Swiss-Prot: OPSX_HUMAN, O14718
Function: May play a role in rpe physiology either by detecting light directly or by monitoring the concentration
of retinoids or other photoreceptor-derived compounds

Gene Wiki entry for RRH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the RRH gene promoter:
         CREB   Sp1   p53   ATF-2   STAT3   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRRH promoter sequence
   Search Chromatin IP Primers for RRH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RRH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25   Ensembl cytogenetic band:  4q25   HGNC cytogenetic band: 4q25

RRH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RRH gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P110749:  view genomic region     (about GC identifiers)

Start:
110,749,150 bp from pter      End:
110,765,863 bp from pter
Size:
16,714 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: OPSX_HUMAN, O14718 (See protein sequence)
Recommended Name: Visual pigment-like receptor peropsin  
Size: 337 amino acids; 37423 Da
Secondary accessions: A1A4V2 Q7RTS4

Explore the universe of human proteins at neXtProt for RRH: NX_O14718

Explore proteomics data for RRH at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn8

  • See RRH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006574.1  
    ENSEMBL proteins: 
     ENSP00000314992  
    Reactome Protein details: O14718

    RRH Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RRH
    GenScript Custom Purified and Recombinant Proteins Services for RRH
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RRH

     
    Search eBioscience for Proteins for RRH 

    RRH Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RRH
    OriGene Custom Antibody Services for RRH
    Novus Biologicals RRH Antibodies
    Abcam antibodies for RRH
    Cloud-Clone Corp. Antibodies for RRH
    ThermoFisher Antibodies for RRH
    LSBio Antibodies in human, mouse, rat for RRH

    RRH Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RRH
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RRH
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RRH
    Cloud-Clone Corp. CLIAs for RRH
    Search eBioscience for ELISAs for RRH 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    OPN: GPCR / Class A : Opsin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002962 Peropsin
     IPR027430 Retinal_BS
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O14718

    ProtoNet protein and cluster: O14718

    2 Blocks protein domains:
    IPB001760 Opsin
    IPB002962 Peropsin signature


    UniProtKB/Swiss-Prot: OPSX_HUMAN, O14718
    Similarity: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily


    Find genes that share domains with RRH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OPSX_HUMAN, O14718
    Function: May play a role in rpe physiology either by detecting light directly or by monitoring the concentration
    of retinoids or other photoreceptor-derived compounds

         Genatlas biochemistry entry for RRH:
    peropsin,retinol pigment epithelium-derived,rhodopsin homolog,located in the apical microvilli of RPE,putative
    regulator of RPE function or activity

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0009881photoreceptor activity IEA--
         
    Find genes that share ontologies with RRH           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RRH:
     Increased circadian period len  Metaphase cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RRH
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RRH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RRH
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RRH

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat RRH using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate RRH:
    hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmidRRH 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RRH
    Predesigned siRNA for gene silencing in human, mouse, rat RRH

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RRH

    Clone
    Products:
         
    OriGene clones in human, mouse for RRH (see all 7)
    OriGene ORF clones in mouse, rat for RRH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RRH (NM_006583)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RRH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRH

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RRH
    Browse ESI BIO Cell Lines and PureStem Progenitors for RRH 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRH


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    OPSX_HUMAN, O14718: Membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS9275222
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with RRH           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RRH About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Opsins
    Opsins


    Find genes that share SuperPaths with RRH           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RRH
        GPCRs, Class A Rhodopsin-like

    2 Reactome Pathways for RRH
        G alpha (i) signalling events
    Opsins


        Pathway & Disease-focused RT2 Profiler PCR Array including RRH: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RRH

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for RRH (O147183 ENSP000003149924) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TGFBR1P368973, ENSP000003641334I2D: score=3 STRING: ENSP00000364133
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS9275222
    GO:0007601visual perception IEA--
    GO:0007602phototransduction IEA--
    GO:0018298protein-chromophore linkage IEA--

    Find genes that share ontologies with RRH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RRH (OPSX)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RRH gene: 
    NM_006583.2  

    Unigene Cluster for RRH:

    Retinal pigment epithelium-derived rhodopsin homolog
    Hs.658310  [show with all ESTs]
    Unigene Representative Sequence: NM_006583
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000317735(uc003hzv.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RRH using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate RRH:
    hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmidRRH 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RRH
    Predesigned siRNA for gene silencing in human, mouse, rat RRH
    Clone
    Products:
         
    OriGene clones in human, mouse for RRH (see all 7)
    OriGene ORF clones in mouse, rat for RRH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RRH (NM_006583)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RRH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRH
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RRH
    OriGene qSTAR qPCR primer pairs in human, mouse for RRH
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RRH
      QuantiTect SYBR Green Assays in human, mouse, rat RRH
      QuantiFast Probe-based Assays in human, mouse, rat RRH

    Additional mRNA sequence: 

    AF012270.1 BC128120.1 BC128121.1 BC128401.1 

    3 DOTS entries:

    DT.40281681  DT.121268495  DT.121268496 

    4 AceView cDNA sequences:

    BM931227 NM_006583 AF012270 D59750 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RRH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGTTTCTA
    RRH Expression
    About this image


    RRH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Brain (Nervous System)
             Mature Choroid Plexus Cells Choroid Plexus
    RRH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RRH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.658310

    UniProtKB/Swiss-Prot: OPSX_HUMAN, O14718
    Tissue specificity: Found only in the eye, where it is localized to the retinal pigment epithelium (RPE). In the
    RPE, it is localized to the microvilli that surround the photoreceptor outer segments

        Pathway & Disease-focused RT2 Profiler PCR Array including RRH: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RRH
    OriGene qSTAR qPCR primer pairs in human, mouse for RRH
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RRH
    QuantiTect SYBR Green Assays in human, mouse, rat RRH
    QuantiFast Probe-based Assays in human, mouse, rat RRH
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for RRH gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rrh1 , 5 retinal pigment epithelium derived rhodopsin homolog1, 5 82.78(n)1
    80.24(a)1
      3 (59.09 cM)5
    201321  NM_009102.31  NP_033128.11 
     1298085755 
    chicken
    (Gallus gallus)
    Aves RRH1 retinal pigment epithelium-derived rhodopsin homolog 74.75(n)
    76.05(a)
      771805  NM_001079759.2  NP_001073227.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    74(a)
    71(a)
    1 ↔ many
    1 ↔ many
    AAWZ02038674(3545-10340)
    5(144365885-144373133)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rrh1 retinal pigment epithelium-derived rhodopsin homolog 71.76(n)
    73.09(a)
      100492717  XM_002934242.2  XP_002934288.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rrh1 retinal pigment epithelium-derived rhodopsin homolog 66.77(n)
    71.25(a)
      447916  NM_001004654.1  NP_001004654.1 


    ENSEMBL Gene Tree for RRH (if available)
    TreeFam Gene Tree for RRH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RRH gene
    OPN32  RGR2  OPN1MW22  OPN42  OPN1LW2  OPN1MW2  OPN1SW2  RHO2  
    OPN52  
    9 SIMAP similar genes for RRH using alignment to 1 protein entry:     OPSX_HUMAN:
    OPN5    RHO    OPN1MW    OPN1MW2    DKFZp781I1948    OPN1LW
    OPN4    OPN3    RGR

    Find genes that share paralogs with RRH           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RRH (see all 440)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs102131041,2
    C,F--110747184(+) ttttgC/Ttcttg 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1898686691,2
    --110747278(+) CTCCCA/TAGTAG 1 -- us2k10--------
    rs779733051,2
    --110747654(+) TTAGAA/TATAAT 1 -- us2k10--------
    rs1396021511,2
    C--110747742(+) CAAATG/TCAAAA 1 -- us2k10--------
    rs1821712831,2
    --110747791(+) ACAAAC/GACTTT 1 -- us2k10--------
    rs100007621,2
    C,F,H--110747864(+) ACTGAC/TGAGAT 1 -- us2k17Minor allele frequency- T:0.02NS EA NA WA 542
    rs1875433431,2
    --110747883(+) CTAGTA/GTAGGT 1 -- us2k10--------
    rs1929648551,2
    --110747959(+) ACCTGG/TTCATC 1 -- us2k10--------
    rs1829761931,2
    C--110748194(+) AAAGAA/GTATGG 1 -- us2k10--------
    rs100257061,2
    C,F,H--110748205(+) GAAAAA/GAGGTA 1 -- us2k1 trp312Minor allele frequency- G:0.06NS EA NA CSA WA 1538

    HapMap Linkage Disequilibrium report for RRH (110749150 - 110765863 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RRH: --
    Human Gene Mutation Database (HGMD): RRH
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RRH
    DNA2.0 Custom Variant and Variant Library Synthesis for RRH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605224    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for RRH:
    Retinitis pigmentosa

    Find genes that share disorders with RRH           About GenesLikeMe

    1 Novoseek inferred disease relationship for RRH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinitis pigmentosa 69.1 3 17167409 (2), 12542842 (1)

    Genetic Association Database (GAD): RRH
    Human Genome Epidemiology (HuGE) Navigator: RRH (1 document)

    Export disorders for RRH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RRH gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with RRH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium. (PubMed id 9275222)1, 2, 3, 9 Sun H.... Nathans J. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. In silico characterisation and chromosomal localisation of human RRH (peropsin) -- implications for opsin evolution. (PubMed id 12542842)1, 2, 9 Bellingham J.... Foster R.G. (BMC Genomics 2003)
    3. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    4. Mutation screening of the peropsin gene, a retinal pigment epithelium specific rhodopsin homolog, in patients with retinitis pigmentosa and allied diseases. (PubMed id 17167409)1, 9 Rivolta C....Dryja T.P. (Mol. Vis. 2006)
    5. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)1 Luttrell L.M. (Mol. Biotechnol. 2008)
    6. High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (Science 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Creation of genome-wide protein expression libraries using random activation of gene expression. (PubMed id 11329013)1 Harrington J.J.... Ducar M. (Nat. Biotechnol. 2001)
    10. A new locus for autosomal dominant high myopia maps to 4q22-q27 between D4S1578 and D4S1612. (PubMed id 16052171)9 Zhang Q....Hejtmancik J.F. (Mol. Vis. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10692 HGNC: 10450 AceView: RRH Ensembl:ENSG00000180245 euGenes: HUgn10692
    ECgene: RRH H-InvDB: RRH

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RRH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RRH gene:
    Search GeneIP for patents involving RRH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RRH   OriGene RNAi products in human, mouse, rat for RRH  
     OriGene qPCR primer pairs and template standards for RRH   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RRH  
     OriGene qSTAR qPCR primer pairs in human, mouse for RRH   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RRH   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RRH   OriGene Custom Protein Services for RRH  

     
     
     Block miRNA regulation of human, mouse, rat RRH using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RRH
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RRH Predesigned siRNA for gene silencing in human, mouse, rat RRH
     QuantiFast Probe-based Assays in human, mouse, rat RRH QuantiTect SYBR Green Assays in human, mouse, rat RRH
     PCR Arrays including human, mouse, rat RRH Search Chromatin IP Primers for RRH
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RRH  Search GeneGlobe Interaction Network for RRH
     Regulatory tfbs in RRH promoter
     GenScript Custom Purified and Recombinant Proteins Services for RRH GenScript cDNA clones with any tag delivered in your preferred vector for RRH
     GenScript Custom Assay Services for RRH GenScript Custom overexpressing Cell Line Services for RRH
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RRH (OPSX)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RRH antibodies
     Antibodies for RRH
     See all of Abcam's Antibodies, Kits and Proteins for RRH
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RRH
     Antibodies for RRH
     ELISAs for RRH
     CLIAs for RRH



     Browse ESI BIO Cell Lines and PureStem Progenitors for RRH
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRH
     SwitchGear 3'UTR luciferase reporter plasmids for RRH
     SwitchGear Promoter luciferase reporter plasmids for RRH
     ThermoFisher Antibodies for RRH
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRH
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RRH
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RRH
     LSBio Antibodies in human, mouse, rat for RRH
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for RRH
      Search eBioscience for proteins for RRH
      Search eBioscience for elisas for RRH
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RRH gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4