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Aliases for RRH Gene

Aliases for RRH Gene

  • Retinal Pigment Epithelium-Derived Rhodopsin Homolog 2 3 5
  • Peropsin 2 3

External Ids for RRH Gene

Previous GeneCards Identifiers for RRH Gene

  • GC04U990073
  • GC04P111019
  • GC04P111142
  • GC04P111207
  • GC04P111106
  • GC04P110968
  • GC04P110749
  • GC04P106481

Summaries for RRH Gene

Entrez Gene Summary for RRH Gene

  • Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes opsin 5 and retinal G protein coupled receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for RRH Gene

RRH (Retinal Pigment Epithelium-Derived Rhodopsin Homolog) is a Protein Coding gene. Diseases associated with RRH include retinitis pigmentosa. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and photoreceptor activity. An important paralog of this gene is OPN1SW.

UniProtKB/Swiss-Prot for RRH Gene

  • May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.

Gene Wiki entry for RRH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRH Gene

Genomics for RRH Gene

Regulatory Elements for RRH Gene

Genomic Location for RRH Gene

109,827,994 bp from pter
109,844,707 bp from pter
16,714 bases
Plus strand

Genomic View for RRH Gene

Genes around RRH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRH Gene

Proteins for RRH Gene

  • Protein details for RRH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Visual pigment-like receptor peropsin
    Protein Accession:
    Secondary Accessions:
    • A1A4V2
    • Q7RTS4

    Protein attributes for RRH Gene

    337 amino acids
    Molecular mass:
    37423 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RRH Gene

Proteomics data for RRH Gene at MOPED

Post-translational modifications for RRH Gene

  • Glycosylation at Asn 8
  • Modification sites at PhosphoSitePlus

Other Protein References for RRH Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RRH Gene

Domains & Families for RRH Gene

Gene Families for RRH Gene

Protein Domains for RRH Gene

Suggested Antigen Peptide Sequences for RRH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
  • Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
genes like me logo Genes that share domains with RRH: view

Function for RRH Gene

Molecular function for RRH Gene

GENATLAS Biochemistry:
peropsin,retinol pigment epithelium-derived,rhodopsin homolog,located in the apical microvilli of RPE,putative regulator of RPE function or activity
UniProtKB/Swiss-Prot Function:
May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.

Gene Ontology (GO) - Molecular Function for RRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008020 G-protein coupled photoreceptor activity IBA --
genes like me logo Genes that share ontologies with RRH: view
genes like me logo Genes that share phenotypes with RRH: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RRH Gene

Localization for RRH Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRH Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for RRH Gene COMPARTMENTS Subcellular localization image for RRH gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for RRH Gene

Pathways & Interactions for RRH Gene

genes like me logo Genes that share pathways with RRH: view

Pathways by source for RRH Gene

Gene Ontology (GO) - Biological Process for RRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007601 visual perception IEA --
GO:0071482 cellular response to light stimulus IBA --
genes like me logo Genes that share ontologies with RRH: view

No data available for SIGNOR curated interactions for RRH Gene

Drugs & Compounds for RRH Gene

No Compound Related Data Available

Transcripts for RRH Gene

mRNA/cDNA for RRH Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RRH Gene

Retinal pigment epithelium-derived rhodopsin homolog:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RRH Gene

No ASD Table

Relevant External Links for RRH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RRH Gene

mRNA expression in normal human tissues for RRH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RRH Gene

This gene is overexpressed in Brain - Cerebellum (x4.0).

Protein differential expression in normal tissues from HIPED for RRH Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RRH Gene

SOURCE GeneReport for Unigene cluster for RRH Gene Hs.658310

mRNA Expression by UniProt/SwissProt for RRH Gene

Tissue specificity: Found only in the eye, where it is localized to the retinal pigment epithelium (RPE). In the RPE, it is localized to the microvilli that surround the photoreceptor outer segments.
genes like me logo Genes that share expression patterns with RRH: view

Protein tissue co-expression partners for RRH Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for RRH Gene

This gene was present in the common ancestor of chordates.

Orthologs for RRH Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RRH 35
  • 90.8 (n)
  • 89.91 (a)
RRH 36
  • 90 (a)
(Canis familiaris)
Mammalia RRH 35
  • 90.58 (n)
  • 91.07 (a)
RRH 36
  • 88 (a)
(Mus musculus)
Mammalia Rrh 35
  • 82.78 (n)
  • 80.24 (a)
Rrh 16
Rrh 36
  • 78 (a)
(Pan troglodytes)
Mammalia RRH 35
  • 99.9 (n)
  • 100 (a)
RRH 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rrh 35
  • 82.11 (n)
  • 76.59 (a)
(Monodelphis domestica)
Mammalia RRH 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia RRH 36
  • 65 (a)
(Gallus gallus)
Aves RRH 35
  • 74.75 (n)
  • 76.05 (a)
RRH 36
  • 77 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 71 (a)
-- 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rrh 35
  • 71.76 (n)
  • 73.09 (a)
(Danio rerio)
Actinopterygii rrh 35
  • 66.77 (n)
  • 71.25 (a)
rrh 36
  • 62 (a)
Species with no ortholog for RRH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RRH Gene

Gene Tree for RRH (if available)
Gene Tree for RRH (if available)

Paralogs for RRH Gene

Paralogs for RRH Gene

(9) SIMAP similar genes for RRH Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RRH: view

Variants for RRH Gene

Sequence variations from dbSNP and Humsavar for RRH Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs4698749 -- 109,836,737(+) AAACC(C/T)GATCT intron-variant
rs4698750 -- 109,837,395(+) CTTAG(G/T)ACATT intron-variant
rs4698795 -- 109,837,613(+) AAGAG(A/G)TCAAA intron-variant
rs4698796 -- 109,843,797(+) AATCT(A/G)TAGAA intron-variant
rs6533468 -- 109,841,796(+) TATGG(G/T)TTTAT intron-variant

Variation tolerance for RRH Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRH Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RRH Gene

Disorders for RRH Gene

MalaCards: The human disease database

(1) MalaCards diseases for RRH Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards
Search RRH in MalaCards View complete list of genes associated with diseases

Relevant External Links for RRH

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RRH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RRH Gene

Publications for RRH Gene

  1. Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium. (PMID: 9275222) Sun H. … Nathans J. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23 67
  2. Mutation screening of the peropsin gene, a retinal pigment epithelium specific rhodopsin homolog, in patients with retinitis pigmentosa and allied diseases. (PMID: 17167409) Rivolta C. … Dryja T.P. (Mol. Vis. 2006) 3 23
  3. In silico characterisation and chromosomal localisation of human RRH (peropsin) -- implications for opsin evolution. (PMID: 12542842) Bellingham J. … Foster R.G. (BMC Genomics 2003) 3 23
  4. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3
  5. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PMID: 18240029) Luttrell L.M. (Mol. Biotechnol. 2008) 3

Products for RRH Gene

Sources for RRH Gene

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