RRH Gene
protein-coding GIFtS: 57
GCID: GC04P110749
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|
retinal pigment epithelium-derived rhodopsin homolog
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Aliases
for RRH gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Retinal Pigment Epithelium-Derived Rhodopsin Homolog1 2 | | Peropsin1 | | Visual Pigment-Like Receptor Peropsin2 |
Export aliases for RRH gene to outside databasesPrevious GC identifers: GC04U990073 GC04P111019 GC04P111142 GC04P111207 GC04P111106 GC04P110968 GC04P106481 |
Summaries
for RRH gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RRH:
Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This genebelongs to the seven-exon subfamily of mammalian opsin genes that includes opsin 5 and retinal G protein coupledreceptor. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: OPSX_HUMAN, O14718Function: May play a role in rpe physiology either by detecting light directly or by monitoring the concentration ofretinoids or other photoreceptor-derived compounds
Gene Wiki entry for RRH
|
Genomic Views
for RRH gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RRH gene promoter:
CREB Sp1 p53 ATF-2 STAT3 STAT5A
Other transcription factors
Search SABiosciences Chromatin IP Primers for RRH
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RRH |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q25 Ensembl cytogenetic band: 4q25 HGNC cytogenetic band: 4q25RRH Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P110749: view genomic region
(about GC identifiers)
Start:
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110,749,150 bp from pter |
End:
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110,765,863 bp from pter |
Size:
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16,714 bases |
Orientation:
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plus strand |
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Proteins
for RRH gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OPSX_HUMAN, O14718 (See
protein sequence)Recommended Name: Visual pigment-like receptor peropsin Size: 337 amino acids; 37423 Da
Subcellular location: Membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: A1A4V2 Q7RTS4Explore the universe of human proteins at neXtProt for RRH: NX_O14718
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O14718
RRH Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006574.1
ENSEMBL proteins: ENSP00000314992 Reactome Protein details: O14718
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005887 | integral to plasma membrane |
TAS | 9275222 |
RRH for ontologies About GeneDecksing
RRH Antibody Products:
Assay Products for RRH: |
Protein
Domains /
Families
for RRH gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RRH for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O14718ProtoNet protein and cluster: O14718 2 Blocks protein families: IPB001760 Opsin IPB002962 Peropsin signature
UniProtKB/Swiss-Prot: OPSX_HUMAN, O14718Similarity: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily |
Function
for RRH gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: OPSX_HUMAN, O14718Function: May play a role in rpe physiology either by detecting light directly or by monitoring the concentration ofretinoids or other photoreceptor-derived compounds Genatlas biochemistry entry for RRH:peropsin,retinol pigment epithelium-derived,rhodopsin homolog,located in the apical microvilli of RPE,putativeregulator of RPE function or activity
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RRH
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: RRH (NM_006583) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RRH | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRH |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRH |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0009881 | photoreceptor activity |
IEA | -- |
RRH for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for RRH:
|
Pathways & Interactions
for RRH gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | Opsins | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for RRH
5/7 
Reactome Pathways for RRH (see all 7)
RRH for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RRH
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for RRH (O147183 ENSP000003149924) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
RRH for ontologies About GeneDecksing
|
Drugs & Compounds
for RRH gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RRH
Search CenterWatch for drugs/clinical trials and news about RRH / OPSX
|
Transcripts
for RRH gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RRH gene: NM_006583.2 Unigene Cluster for RRH: Retinal pigment epithelium-derived rhodopsin homolog Hs.658310 [show with all ESTs]Unigene Representative Sequence: NM_0065831 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000317735(uc003hzv.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RRH (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RRH
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RRH (NM_006583) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RRH | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRH |
Additional cDNA sequence: AF012270.1 BC128120.1 BC128121.1 BC128401.1 3 DOTS entries: DT.40281681 DT.121268495 DT.121268496 4 AceView cDNA sequences: AF012270 NM_006583 BM931227 D59750
GeneLoc Exon Structure
|
Expression
for RRH gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RRH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTGTTTCTA
About this image
See RRH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RRH
SOURCE GeneReport for Unigene cluster: Hs.658310
UniProtKB/Swiss-Prot: OPSX_HUMAN, O14718Tissue specificity: Found only in the eye, where it is localized to the retinal pigment epithelium (RPE). In the RPE,it is localized to the microvilli that surround the photoreceptor outer segments
SABiosciences Expression via Pathway-Focused PCR Array including RRH:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RRH
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RRH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RRH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RRH | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRH |
Orthologs
for RRH gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for RRH gene from 3/13 species (see all 13) About this table
ENSEMBL Gene Tree for RRH (if available)
TreeFam Gene Tree for RRH (if available) |
Paralogs
for RRH gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RRH gene
- OPN32 OPN1MW2 OPN1SW2 RHO2 RGR2 OPN42 OPN1MW22 OPN1LW2
- OPN52
9 SIMAP similar genes for RRH using alignment to 1 protein entry: OPSX_HUMAN:OPN5 RHO OPN1MW OPN1MW2 DKFZp781I1948 OPN1LW
OPN4 OPN3 RGR
RRH for paralogs About GeneDecksing
|
Genomic Variants
for RRH gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Human Gene Mutation Database (HGMD): RRH
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RRH |
|
Disorders
/ Diseases
for RRH gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RRH for disorders About GeneDecksing
OMIM gene information: 605224
OMIM disorders: --
6  diseases for RRH: About MalaCardsretinitis retinitis pigmentosa alcohol dependence stomach cancer
myopia alcoholism
1 disease from the University of Copenhagen DISEASES database for RRH:Retinitis pigmentosa 1 Novoseek disease relationship for RRH gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| retinitis pigmentosa |
69.1 |
3 |
17167409 (2), 12542842 (1) |
Human Genome Epidemiology (HuGE) Navigator: RRH (1 document)
Export disorders for RRH gene to outside databases
|
Publications
for RRH gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RRH gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with RRH) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium. (PubMed id 9275222)1, 2, 3, 9 Sun H.... Nathans J. (1997)
- In silico characterisation and chromosomal localisation of human RRH (peropsin) -- implications for opsin evolution. (PubMed id 12542842)1, 2, 9 Bellingham J.... Foster R.G. (2003)
- Mutation screening of the peropsin gene, a retinal pigment epithelium specific rhodopsin homolog, in patients with retinitis pigmentosa and allied diseases. (PubMed id 17167409)1, 9 Rivolta C....Dryja T.P. (2006)
- A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)1 Kalsi G....Riley B.P. (2010)
- Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)1 Luttrell L.M. (2008)
- High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Creation of genome-wide protein expression libraries using random activation of gene expression. (PubMed id 11329013)1 Harrington J.J.... Ducar M. (2001)
- A new locus for autosomal dominant high myopia maps to 4q22-q27 between D4S1578 and D4S1612. (PubMed id 16052171)9 Zhang Q....Hejtmancik J.F. (2005)
|
External Searches for RRH gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RRH gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RRH gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RRH gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RRH | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RRH gene:
Search GeneIP for patents involving RRH
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RRH gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RRH | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RRH | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RRH | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RRH | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RRH | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RRH | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RRH | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RRH | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RRH | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RRH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RRH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RRH |
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 |  |  |  | |
| | | | Search Tocris compounds for RRH |
| |  |  |  |  | | | | |
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 | | | RRH Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRH |
|  |  |  | | | | ThermoFisher Antibodies for RRH |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRH |
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