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Aliases for RREB1 Gene

Aliases for RREB1 Gene

  • Ras Responsive Element Binding Protein 1 2 3
  • Zinc Finger Motif Enhancer-Binding Protein 1 3 4
  • Raf-Responsive Zinc Finger Protein LZ321 3 4
  • Finger Protein In Nuclear Bodies 3 4
  • RREB-1 3 4
  • Zep-1 3 4
  • FINB 3 4
  • Zinc Finger Motif Enhancer Binding Protein 1 3
  • Zinc Finger Motif-Enhancer Binding-Protein 1 3
  • Ras-Responsive Element-Binding Protein 1 3
  • Hindsight Homolog (Drosophila) 2
  • DNA-Binding Protein 3
  • Hindsight Homolog 3
  • LZ321 3
  • HNT 3

External Ids for RREB1 Gene

Summaries for RREB1 Gene

Entrez Gene Summary for RREB1 Gene

  • The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for RREB1 Gene

RREB1 (Ras Responsive Element Binding Protein 1) is a Protein Coding gene. Diseases associated with RREB1 include vulvar melanoma and substance-induced psychosis. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF821.

UniProtKB/Swiss-Prot for RREB1 Gene

  • Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1.

Gene Wiki entry for RREB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RREB1 Gene

Genomics for RREB1 Gene

Genomic Location for RREB1 Gene

Start:
7,107,597 bp from pter
End:
7,251,980 bp from pter
Size:
144,384 bases
Orientation:
Plus strand

Genomic View for RREB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RREB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RREB1 Gene

Regulatory Elements for RREB1 Gene

Proteins for RREB1 Gene

  • Protein details for RREB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92766-RREB1_HUMAN
    Recommended name:
    Ras-responsive element-binding protein 1
    Protein Accession:
    Q92766
    Secondary Accessions:
    • A2RRF5
    • E2GM80
    • E2GM81
    • O75567
    • O75568
    • Q5VYB2
    • Q6BEP5
    • Q6BEP6
    • Q6BEP8
    • Q86SU2
    • Q9Y474

    Protein attributes for RREB1 Gene

    Size:
    1687 amino acids
    Molecular mass:
    181420 Da
    Quaternary structure:
    • Interacts with NEUROD1 and AR.
    SequenceCaution:
    • Sequence=AAB19094.1; Type=Frameshift; Positions=908, 1350, 1383; Evidence={ECO:0000305}; Sequence=AAC25598.1; Type=Frameshift; Positions=1350, 1383; Evidence={ECO:0000305}; Sequence=AAC26118.1; Type=Frameshift; Positions=1350, 1383; Evidence={ECO:0000305}; Sequence=AAH42910.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH42910.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA23165.1; Type=Miscellaneous discrepancy; Note=Numerous sequencing errors.; Evidence={ECO:0000305}; Sequence=CAH73521.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RREB1 Gene

neXtProt entry for RREB1 Gene

Proteomics data for RREB1 Gene at MOPED

Post-translational modifications for RREB1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys435

No data available for DME Specific Peptides for RREB1 Gene

Domains for RREB1 Gene

Gene Families for RREB1 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for RREB1 Gene

UniProtKB/Swiss-Prot:

RREB1_HUMAN
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q92766
Similarity:
  • Contains 15 C2H2-type zinc fingers.:
    • Q92766
genes like me logo Genes that share domains with RREB1: view

Function for RREB1 Gene

Molecular function for RREB1 Gene

GENATLAS Biochemistry: RAS responsive element binding protein
UniProtKB/Swiss-Prot Function: Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1.

Gene Ontology (GO) - Molecular Function for RREB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IMP 20133935
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RREB1: view

Phenotypes for RREB1 Gene

GenomeRNAi human phenotypes for RREB1:
genes like me logo Genes that share phenotypes with RREB1: view

miRNA for RREB1 Gene

Transcription Factor Targeting for RREB1 Gene

Selected GeneGlobe predicted Target genes for RREB1

No data available for Enzyme Numbers (IUBMB) , Animal Models and HOMER Transcription for RREB1 Gene

Localization for RREB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RREB1 Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RREB1 Gene COMPARTMENTS Subcellular localization image for RREB1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for RREB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9305772
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm TAS 9305772
GO:0016604 nuclear body TAS 9305772
genes like me logo Genes that share ontologies with RREB1: view

Pathways for RREB1 Gene

SuperPathways for RREB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RREB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 20133935
GO:0006355 regulation of transcription, DNA-templated TAS 9305772
GO:0006366 transcription from RNA polymerase II promoter TAS 8816445
GO:0007265 Ras protein signal transduction TAS 8816445
GO:0007275 multicellular organismal development TAS 8816445
genes like me logo Genes that share ontologies with RREB1: view

No data available for Pathways by source for RREB1 Gene

Compounds for RREB1 Gene

(1) HMDB Compounds for RREB1 Gene

Compound Synonyms Cas Number PubMed IDs
Zinc
  • Zinc
7440-66-6

(1) Novoseek inferred chemical compound relationships for RREB1 Gene

Compound -log(P) Hits PubMed IDs
zinc 57.4 7
genes like me logo Genes that share compounds with RREB1: view

Transcripts for RREB1 Gene

Unigene Clusters for RREB1 Gene

Ras responsive element binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RREB1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2: - - -
SP3: - - -
SP4:
SP5: -
SP6:

Relevant External Links for RREB1 Gene

GeneLoc Exon Structure for
RREB1
ECgene alternative splicing isoforms for
RREB1

Expression for RREB1 Gene

mRNA expression in normal human tissues for RREB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RREB1 Gene

SOURCE GeneReport for Unigene cluster for RREB1 Gene Hs.298248

mRNA Expression by UniProt/SwissProt for RREB1 Gene

Q92766-RREB1_HUMAN
Tissue specificity: Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not found in the brain.
genes like me logo Genes that share expressions with RREB1: view

Orthologs for RREB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RREB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RREB1 36
  • 99.48 (n)
  • 99.48 (a)
RREB1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RREB1 36
  • 81.51 (n)
  • 79.74 (a)
RREB1 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RREB1 36
  • 85.55 (n)
  • 84.62 (a)
RREB1 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rreb1 36
  • 82.01 (n)
  • 81.32 (a)
Rreb1 16
Rreb1 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RREB1 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RREB1 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rreb1 36
  • 80.55 (n)
  • 78.9 (a)
chicken
(Gallus gallus)
Aves RREB1 36
  • 68.91 (n)
  • 67.79 (a)
RREB1 37
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RREB1 37
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5387 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rreb1 36
  • 61.5 (n)
  • 61.37 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 36
rreb1a 36
  • 57.26 (n)
  • 52.44 (a)
rreb1a 37
  • 46 (a)
OneToMany
rreb1b 37
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta peb 37
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 16 (a)
ManyToMany
Species with no ortholog for RREB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RREB1 Gene

ENSEMBL:
Gene Tree for RREB1 (if available)
TreeFam:
Gene Tree for RREB1 (if available)

Paralogs for RREB1 Gene

Paralogs for RREB1 Gene

Pseudogenes.org Pseudogenes for RREB1 Gene

genes like me logo Genes that share paralogs with RREB1: view

Variants for RREB1 Gene

Sequence variations from dbSNP and Humsavar for RREB1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs476948 -- 7,143,918(-) AAATT(C/T)TAGTG intron-variant
rs482393 -- 7,143,371(-) GACCA(C/T)AGCCT intron-variant
rs483107 -- 7,111,818(+) TCCTG(A/G)GGATT intron-variant
rs490826 -- 7,165,143(-) ATCCA(C/T)TGCAG intron-variant
rs496704 -- 7,146,962(-) ACTAA(A/G)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RREB1 Gene

Variant ID Type Subtype PubMed ID
nsv883430 CNV Gain 21882294
nsv823411 CNV Gain 20364138
nsv883431 CNV Gain 21882294
nsv883432 CNV Loss 21882294
nsv818397 CNV Loss 17921354

Relevant External Links for RREB1 Gene

HapMap Linkage Disequilibrium report
RREB1
Human Gene Mutation Database (HGMD)
RREB1

Disorders for RREB1 Gene

(3) University of Copenhagen DISEASES for RREB1 Gene

(1) Novoseek inferred disease relationships for RREB1 Gene

Disease -log(P) Hits PubMed IDs
thyroid carcinoma medullary 59.6 3

Relevant External Links for RREB1

Genetic Association Database (GAD)
RREB1
Human Genome Epidemiology (HuGE) Navigator
RREB1
genes like me logo Genes that share disorders with RREB1: view

No data available for UniProtKB/Swiss-Prot for RREB1 Gene

Publications for RREB1 Gene

  1. The zinc finger protein Ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer. (PMID: 17550981) Mukhopadhyay N.K. … Freeman M.R. (Mol. Endocrinol. 2007) 3 4 23
  2. RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas. (PMID: 8816445) Thiagalingam A. … Nelkin B.D. (Mol. Cell. Biol. 1996) 3 4 23
  3. A human Raf-responsive zinc-finger protein that binds to divergent sequences. (PMID: 10390538) Zhang L. … Edenberg H.J. (Nucleic Acids Res. 1999) 3 4 23
  4. Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1. (PMID: 12482979) Ray S.K. … Leiter A.B. (Mol. Cell. Biol. 2003) 3 4 23
  5. Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene. (PMID: 15067362) Date S. … Fukamizu A. (Int. J. Mol. Med. 2004) 3 4

Products for RREB1 Gene

Sources for RREB1 Gene

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