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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RREB1 Gene

protein-coding   GIFtS: 55
GCID: GC06P007084

ras responsive element binding protein 1
 Explore 14 diseases affiliated with
RREB1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RREB1    

Aliases
for RREB1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ras Responsive Element Binding Protein 11 2     Zep-12 3
HNT1 2     LZ3212
Finger Protein In Nuclear Bodies2 3     DNA-Binding Protein2
Raf-Responsive Zinc Finger Protein LZ3212 3     Hindsight Homolog2
Zinc Finger Motif Enhancer-Binding Protein 12 3     Ras-Responsive Element-Binding Protein 12
FINB2 3     Zinc Finger Motif Enhancer Binding Protein 12
RREB-12 3     Zinc Finger Motif-Enhancer Binding-Protein 12

External Ids:    HGNC: 104491   Entrez Gene: 62392   Ensembl: ENSG000001247827   OMIM: 6022095   UniProtKB: Q927663   

Export aliases for RREB1 gene to outside databases

Previous GC identifers: GC06P007092 GC06P007052 GC06P007053 GC06P006984


Summaries
for RREB1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RREB1:
The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of
gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds
there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple
transcript variants encoding several different isoforms have been found for this gene. (provided by RefSeq, Dec 2009)

UniProtKB/Swiss-Prot: RREB1_HUMAN, Q92766
Function: Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. May be
involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen
gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1

Gene Wiki entry for RREB1


Genomic Views
for RREB1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RREB1 gene promoter:
         GATA-3   ATF-2   Meis-1b   HNF-1A   GATA-2   N-Myc   AREB6   HNF-1   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RREB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RREB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RREB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25   Ensembl cytogenetic band:  6p24.3   HGNC cytogenetic band: 6p25

RREB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RREB1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P007084:  view genomic region     (about GC identifiers)

Start:
 7,107,830 bp from pter      End:
 7,252,213 bp from pter
Size:
 144,384 bases      Orientation:
 plus strand

Proteins
for RREB1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RREB1_HUMAN, Q92766 (See protein sequence)
Recommended Name: Ras-responsive element-binding protein 1  
Size: 1687 amino acids; 181420 Da
Subunit: Interacts with NEUROD1 and AR
Subcellular location: Nucleus speckle
Sequence caution: Sequence=AAB19094.1; Type=Frameshift; Positions=908, 1350, 1383; Sequence=AAC25598.1;
Type=Frameshift; Positions=1350, 1383; Sequence=AAC26118.1; Type=Frameshift; Positions=1350, 1383;
Sequence=AAH42910.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH42910.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA23165.1;
Type=Miscellaneous discrepancy; Note=Numerous sequencing errors; Sequence=CAH73521.1; Type=Erroneous initiation;
Secondary accessions: A2RRF5 O75567 O75568 Q5VYB2 Q6BEP5 Q6BEP6 Q6BEP8 Q86SU2 Q9Y474
Alternative splicing: 4 isoforms:  Q92766-1   Q92766-2   Q92766-3   Q92766-4   (Ref.6 (AAC26118) sequence differs from that shown due to a frameshift in position 1271)

Explore the universe of human proteins at neXtProt for RREB1: NX_Q92766

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92766

    • RREB1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001003698.1  NP_001003699.1  NP_001003700.1  NP_001161816.1  

    ENSEMBL proteins: 
     ENSP00000369265   ENSP00000420519   ENSP00000369270   ENSP00000420299   ENSP00000420571  
     ENSP00000305560   ENSP00000335574   ENSP00000419511   ENSP00000419218  

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    Uscn Proteins for RREB1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus TAS9305772
    GO:0005737cytoplasm TAS9305772
    GO:0016604nuclear body TAS9305772
    GO:0016607nuclear speck IEA--


    RREB1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for RREB1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RREB1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q92766

    ProtoNet protein and cluster: Q92766

    1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: RREB1_HUMAN, Q92766
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 15 C2H2-type zinc fingers


    Function
    for RREB1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RREB1_HUMAN, Q92766
    Function: Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. May be
    involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen
    gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1

         Genatlas biochemistry entry for RREB1:
    RAS responsive element binding protein

    10/282 SABiosciences Target genes for RREB1 (see all 282):
    AADACL4 AARSD1 ABR ACAD8 ADAMTS18 ANKRD40 APLNR APOC2 APOC4 APOL1

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    Inhib. RNA
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008270zinc ion binding IEA--


    RREB1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for RREB1:
     Synthetic lethal with Ras 


    Pathways & Interactions
    for RREB1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RREB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for RREB1 (Q927663 ENSP000003692704) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    NEUROD1Q135623, ENSP000002951084I2D: score=1 STRING: ENSP00000295108
    CTBP1Q133633, ENSP000002909214I2D: score=1 STRING: ENSP00000290921
    KDM1AO603413, ENSP000003490494I2D: score=1 STRING: ENSP00000349049
    HIST3H3Q166953, ENSP000003556574I2D: score=1 STRING: ENSP00000355657
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent TAS9305772
    GO:0006366transcription from RNA polymerase II promoter TAS8816445
    GO:0007265Ras protein signal transduction TAS8816445
    GO:0007275multicellular organismal development TAS8816445
    GO:0045892negative regulation of transcription, DNA-dependent IEA--


    RREB1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RREB1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RREB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RREB1

    1 HMDB Compound for RREB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--
    1 Novoseek chemical compound relationship for RREB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 57.4 8 9427563 (3), 8816445 (2), 17550981 (1), 18190854 (1)

    Search CenterWatch for drugs/clinical trials and news about RREB1 

    Transcripts
    for RREB1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RREB1 gene (5 alternative transcripts): 
    NM_001003698.3  NM_001003699.3  NM_001003700.1  NM_001168344.1  NM_002955.4  

    Unigene Cluster for RREB1:

    Ras responsive element binding protein 1
    Hs.298248  [show with all ESTs]
    Unigene Representative Sequence: NM_001003699
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379933 ENST00000491191 ENST00000379938(uc021yky.1 uc010jnw.3 uc003mxb.3 uc003mxc.3 uc010jnx.3 uc021ykz.1 uc021yla.1)
    ENST00000471433 ENST00000467782 ENST00000349384 ENST00000334984 ENST00000475946(uc003mxd.3)
    ENST00000483150 ENST00000492574

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    hsa-miR-582-3p hsa-miR-3678-3p hsa-miR-15a hsa-miR-199a-3p hsa-miR-128 hsa-miR-1245 hsa-miR-342-3p hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmid: RREB1 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AB019254.1 AB019351.1 AB019352.1 AF072825.1 AF072826.1 BC032062.1 BC042910.2 BC111386.1 
    BC131599.1 D49835.1 U26914.1 

    18 DOTS entries:

    DT.92430880  DT.100036523  DT.95177528  DT.100766832  DT.100748175  DT.105872  DT.121328334  DT.121328471 
    DT.100808521  DT.214641  DT.101965501  DT.121328469  DT.40204066  DT.75169201  DT.91667030  DT.91698760 
    DT.91876505  DT.95254815 

    24/231 AceView cDNA sequences (see all 231):

    AI587262 BP366145 BU859660 AA256198 BX955992 AW139366 AA102122 AI679131 
    AI446278 BF475814 BM699086 AI361819 BC032062 AA515213 AA856743 AI278685 
    NM_001003699 AW469442 CB144053 NM_002955 BF901096 BI826215 CA942427 BU538534 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RREB1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                    -                                         -                                 
    SP2:                    -                                         -                       -         
    SP3:                    -                                         -                 -               
    SP4:                                                                                                
    SP5:                    -                                                                           


    ECgene alternative splicing isoforms for RREB1

    Expression
    for RREB1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RREB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACAGACATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RREB1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainHypothalamusBrain
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordSpinal Dorsal ColumnsSpinal Cord
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RREB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RREB1

    SOURCE GeneReport for Unigene cluster: Hs.298248

    UniProtKB/Swiss-Prot: RREB1_HUMAN, Q92766
    Tissue specificity: Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not found in the
    brain

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    Orthologs
    for RREB1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RREB1 gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rreb11 , 5 ras responsive element binding protein 11, 5 82.15(n)1
    81.78(a)1    		   13 (17.70 cM)5
    687501  NM_001177869.11  NP_001171340.11 
     377784005 
    chicken
    (Gallus gallus)    		 Aves RREB11 ras responsive element binding protein 1 68.78(n)
    68.15(a)    		   395920  NM_205049.1  NP_990380.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RREB16
    		 --
    		 62(a)
    		 1 ↔ 1
    		 GL343311.1(150147-218431)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.53872 Xenopus laevis transcribed sequence with weak similarity more 77.9(n)    48043480 
    zebrafish
    (Danio rerio)    		 Actinopterygii BG985521.12   -- 76.3(n)   338237  BG985521.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta peb6
    		 pebbled
    		 16(a)
    		 1 ↔ 1
    		 X(4511602-4520256)


    ENSEMBL Gene Tree for RREB1 (if available)
    TreeFam Gene Tree for RREB1 (if available) 

    Paralogs
    for RREB1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RREB1 gene
    ZNF8212  
    18/112 SIMAP similar genes for RREB1 using alignment to 7 protein entries:     RREB1_HUMAN (see all proteins) (see all similar genes):
    ZSCAN9    ZNF55    ZFS-4    GZF1    ZNF7    ZNF26
    ZFS-5    ZNF213    ZNF219    ZNF300    ZNF562    ZNF
    ZNF78L1    ZNF34    ZNF420    ZFP64    A-328A3.4    ZNF702P

    RREB1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RREB1
    PGOHUM00000243480


    Genomic Variants
    for RREB1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2501 NCBI SNPs in RREB1 are shown (see all 2501)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs733726441,2
    		C,--6982404(+) ACCTAT/CTCTAT 4 -- us2k12Minor allele frequency- C:0.14WA 120
    rs762331721,2
    		C,F,--6982432(+) TTATTC/TCTGTC 4 -- us2k12Minor allele frequency- T:0.05NA EA 240
    rs797024461,2
    		--6982527(+) GGCTCA/CGAAAA 4 -- us2k11Minor allele frequency- C:0.01NA 120
    rs766238411,2
    		F,--6983687(+) GGAAAC/GGGCGC 4 -- us2k11Minor allele frequency- G:0.06NA 120
    rs799785671,2
    		--6986661(+) GTGGAC/TCCTGC 4 -- int11Minor allele frequency- T:0.01NA 120
    rs1130034891,2
    		C,--6986663(+) GGACCC/TTGCAT 4 -- int11Minor allele frequency- T:0.50NA 2
    rs728169091,2
    		C,--6986708(+) AGTGGA/TAGGTG 4 -- int10--------
    rs284993481,2
    		C,,--6987037(+) TGTGTA/GTGTGT 4 -- int10--------
    rs776072511,2
    		F,--6987522(+) CAGGTA/GGTGCA 4 -- int11Minor allele frequency- G:0.04WA 118
    rs763312731,2
    		F,--6987635(+) AGGTAC/GAGCGT 4 -- int11Minor allele frequency- G:0.06WA 118

    HapMap Linkage Disequilibrium report for RREB1 (7107830 - 7252213 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RREB1
         1 CNV: 10139

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    Disorders / Diseases
    for RREB1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RREB1 for disorders           About GeneDecksing

    OMIM gene information: 602209    OMIM disorders: --

    14 diseases for RREB1:    About MalaCards
    age related macular degeneration    nevus    malignant spindle cell melanoma    macular degeneration
    thyroid carcinoma    gout    thyroiditis    melanoma
    prostate cancer    carcinoma    prostatitis    adenocarcinoma
    pancreatitis    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for RREB1:
    substance-induced psychosis     Melanoma

    1 Novoseek disease relationship for RREB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid carcinoma medullary 59.6 3 8816445 (2), 9427563 (1)

    Human Genome Epidemiology (HuGE) Navigator: RREB1 (4 documents)

    Export disorders for RREB1 gene to outside databases

    Publications
    for RREB1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RREB1 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with RREB1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The zinc finger protein Ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer. (PubMed id 17550981)1, 2, 9 Mukhopadhyay N.K.... Freeman M.R. (2007)
    2. RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas. (PubMed id 8816445)1, 2, 9 Thiagalingam A.... Nelkin B.D. (1996)
    3. A human Raf-responsive zinc-finger protein that binds to divergent sequences. (PubMed id 10390538)1, 2, 9 Zhang L.... Edenberg H.J. (1999)
    4. Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1. (PubMed id 12482979)1, 2, 9 Ray S.K.... Leiter A.B. (2003)
    5. Regulation of cell adhesion and collective cell migra tion by hindsight and its human homolog RREB1. (PubMed id 18394891)1, 3 Melani M....Montell D. (2008)
    6. Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene. (PubMed id 15067362)1, 2 Date S.... Fukamizu A. (2004)
    7. RREB1, a ras responsive element binding protein, maps to human chromosome 6p25. (PubMed id 9367691)1, 3 Thiagalingam A....Nelkin B.D. (1997)
    8. A novel zinc finger protein, Finb, is a transcriptional activator and localized in nuclear bodies. (PubMed id 9305772)1, 2 Fujimoto-Nishiyama A.... Yamamoto T. (1997)
    9. Ras responsive element binding protein-1 (RREB-1) dow n-regulates hZIP1 expression in prostate cancer cells. (PubMed id 19802870)1, 9 Milon B.C....Franklin R.B. (2010)
    10. RREB-1 is a transcriptional repressor of HLA-G. (PubMed id 19890057)1, 9 Flajollet S....Moreau P. (2009)

    External Searches for RREB1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RREB1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6239 HGNC: 10449 AceView: RREB1 Ensembl:ENSG00000124782 euGenes: HUgn6239
    ECgene: RREB1 H-InvDB: RREB1

    Other Databases showing RREB1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RREB1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RREB1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RREB1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RREB1 gene:
    Search GeneIP for patents involving RREB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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