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Aliases for RREB1 Gene

Aliases for RREB1 Gene

  • Ras Responsive Element Binding Protein 1 2 3 5
  • Zinc Finger Motif Enhancer-Binding Protein 1 3 4
  • Raf-Responsive Zinc Finger Protein LZ321 3 4
  • Finger Protein In Nuclear Bodies 3 4
  • RREB-1 3 4
  • Zep-1 3 4
  • FINB 3 4
  • Zinc Finger Motif Enhancer Binding Protein 1 3
  • Zinc Finger Motif-Enhancer Binding-Protein 1 3
  • Hindsight Homolog (Drosophila) 2
  • DNA-Binding Protein 3
  • Hindsight Homolog 3
  • LZ321 3
  • HNT 3

External Ids for RREB1 Gene

Previous GeneCards Identifiers for RREB1 Gene

  • GC06P007092
  • GC06P007052
  • GC06P007053
  • GC06P007084
  • GC06P006984

Summaries for RREB1 Gene

Entrez Gene Summary for RREB1 Gene

  • The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for RREB1 Gene

RREB1 (Ras Responsive Element Binding Protein 1) is a Protein Coding gene. Diseases associated with RREB1 include vulvar melanoma and substance-induced psychosis. GO annotations related to this gene include nucleic acid binding and RNA polymerase II core promoter sequence-specific DNA binding. An important paralog of this gene is CTCFL.

UniProtKB/Swiss-Prot for RREB1 Gene

  • Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1.

Gene Wiki entry for RREB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RREB1 Gene

Genomics for RREB1 Gene

Regulatory Elements for RREB1 Gene

Promoters for RREB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RREB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RREB1 Gene

Chromosome:
6
Start:
7,107,597 bp from pter
End:
7,251,980 bp from pter
Size:
144,384 bases
Orientation:
Plus strand

Genomic View for RREB1 Gene

Genes around RREB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RREB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RREB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RREB1 Gene

Proteins for RREB1 Gene

  • Protein details for RREB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92766-RREB1_HUMAN
    Recommended name:
    Ras-responsive element-binding protein 1
    Protein Accession:
    Q92766
    Secondary Accessions:
    • A2RRF5
    • E2GM80
    • E2GM81
    • O75567
    • O75568
    • Q5VYB2
    • Q6BEP5
    • Q6BEP6
    • Q6BEP8
    • Q86SU2
    • Q9Y474

    Protein attributes for RREB1 Gene

    Size:
    1687 amino acids
    Molecular mass:
    181420 Da
    Quaternary structure:
    • Interacts with NEUROD1 and AR.
    SequenceCaution:
    • Sequence=AAB19094.1; Type=Frameshift; Positions=908, 1350, 1383; Evidence={ECO:0000305}; Sequence=AAC25598.1; Type=Frameshift; Positions=1350, 1383; Evidence={ECO:0000305}; Sequence=AAC26118.1; Type=Frameshift; Positions=1350, 1383; Evidence={ECO:0000305}; Sequence=AAH42910.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH42910.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA23165.1; Type=Miscellaneous discrepancy; Note=Numerous sequencing errors.; Evidence={ECO:0000305}; Sequence=CAH73521.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RREB1 Gene

neXtProt entry for RREB1 Gene

Proteomics data for RREB1 Gene at MOPED

Post-translational modifications for RREB1 Gene

  • Ubiquitination at Lys 435
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for RREB1 Gene

Domains & Families for RREB1 Gene

Gene Families for RREB1 Gene

Protein Domains for RREB1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92766

UniProtKB/Swiss-Prot:

RREB1_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with RREB1: view

Function for RREB1 Gene

Molecular function for RREB1 Gene

GENATLAS Biochemistry:
RAS responsive element binding protein
UniProtKB/Swiss-Prot Function:
Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1.

Gene Ontology (GO) - Molecular Function for RREB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IMP 20133935
genes like me logo Genes that share ontologies with RREB1: view
genes like me logo Genes that share phenotypes with RREB1: view

Animal Model Products

miRNA for RREB1 Gene

miRTarBase miRNAs that target RREB1

Transcription Factor Targets for RREB1 Gene

Selected GeneGlobe predicted Target genes for RREB1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for RREB1 Gene

Localization for RREB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RREB1 Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RREB1 Gene COMPARTMENTS Subcellular localization image for RREB1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for RREB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 9305772
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with RREB1: view

Pathways & Interactions for RREB1 Gene

SuperPathways for RREB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RREB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated TAS 9305772
GO:0010634 positive regulation of epithelial cell migration IMP 18394891
GO:0033601 positive regulation of mammary gland epithelial cell proliferation IMP 18394891
GO:0045892 negative regulation of transcription, DNA-templated IEA --
GO:0045893 positive regulation of transcription, DNA-templated TAS 9305772
genes like me logo Genes that share ontologies with RREB1: view

No data available for Pathways by source and SIGNOR curated interactions for RREB1 Gene

Drugs & Compounds for RREB1 Gene

(1) Drugs for RREB1 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1477
genes like me logo Genes that share compounds with RREB1: view

Transcripts for RREB1 Gene

Unigene Clusters for RREB1 Gene

Ras responsive element binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RREB1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2: - - -
SP3: - - -
SP4:
SP5: -
SP6:

Relevant External Links for RREB1 Gene

GeneLoc Exon Structure for
RREB1
ECgene alternative splicing isoforms for
RREB1

Expression for RREB1 Gene

mRNA expression in normal human tissues for RREB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RREB1 Gene

This gene is overexpressed in Serum (33.9), CD8 Tcells (9.3), Heart (8.4), and Pancreatic juice (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RREB1 Gene



SOURCE GeneReport for Unigene cluster for RREB1 Gene Hs.298248

mRNA Expression by UniProt/SwissProt for RREB1 Gene

Q92766-RREB1_HUMAN
Tissue specificity: Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not found in the brain.
genes like me logo Genes that share expression patterns with RREB1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for RREB1 Gene

Orthologs for RREB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RREB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RREB1 35
  • 81.51 (n)
  • 79.74 (a)
RREB1 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RREB1 35
  • 85.55 (n)
  • 84.62 (a)
RREB1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rreb1 35
  • 82.01 (n)
  • 81.32 (a)
Rreb1 16
Rreb1 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RREB1 35
  • 99.48 (n)
  • 99.48 (a)
RREB1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rreb1 35
  • 80.55 (n)
  • 78.9 (a)
oppossum
(Monodelphis domestica)
Mammalia RREB1 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RREB1 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves RREB1 35
  • 68.91 (n)
  • 67.79 (a)
RREB1 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RREB1 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rreb1 35
  • 61.5 (n)
  • 61.37 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5387 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
rreb1a 35
  • 57.26 (n)
  • 52.44 (a)
rreb1a 36
  • 46 (a)
OneToMany
rreb1b 36
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta peb 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
ManyToMany
Species with no ortholog for RREB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RREB1 Gene

ENSEMBL:
Gene Tree for RREB1 (if available)
TreeFam:
Gene Tree for RREB1 (if available)

Paralogs for RREB1 Gene

Paralogs for RREB1 Gene

Pseudogenes.org Pseudogenes for RREB1 Gene

genes like me logo Genes that share paralogs with RREB1: view

Variants for RREB1 Gene

Sequence variations from dbSNP and Humsavar for RREB1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1334576 - 7,211,585(-) CTGCC(C/T)GTCTT reference, missense
rs9502564 - 7,230,447(+) CGGGG(A/G/T)CCACA reference, missense
rs9379084 - 7,231,610(+) GGGTG(A/G)ACCTG reference, missense
rs2281833 - 7,246,765(+) GCGCC(A/G/T)GGGGC intron-variant, reference, missense
rs2256596 - 7,247,015(+) AAAGC(C/T)CGCGG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RREB1 Gene

Variant ID Type Subtype PubMed ID
nsv883430 CNV Gain 21882294
nsv823411 CNV Gain 20364138
nsv883431 CNV Gain 21882294
nsv883432 CNV Loss 21882294
nsv818397 CNV Loss 17921354

Variation tolerance for RREB1 Gene

Residual Variation Intolerance Score: 41.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.88; 97.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RREB1 Gene

HapMap Linkage Disequilibrium report
RREB1
Human Gene Mutation Database (HGMD)
RREB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RREB1 Gene

Disorders for RREB1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RREB1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
vulvar melanoma
  • malignant melanoma of vulva
substance-induced psychosis
- elite association - COSMIC cancer census association via MalaCards
Search RREB1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RREB1

Genetic Association Database (GAD)
RREB1
Human Genome Epidemiology (HuGE) Navigator
RREB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RREB1
genes like me logo Genes that share disorders with RREB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RREB1 Gene

Publications for RREB1 Gene

  1. The zinc finger protein Ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer. (PMID: 17550981) Mukhopadhyay N.K. … Freeman M.R. (Mol. Endocrinol. 2007) 3 4 23 67
  2. Ras responsive element binding protein-1 (RREB-1) down-regulates hZIP1 expression in prostate cancer cells. (PMID: 19802870) Milon B.C. … Franklin R.B. (Prostate 2010) 3 23
  3. DNA damage signalling recruits RREB-1 to the p53 tumour suppressor promoter. (PMID: 19558368) Liu H. … Yoshida K. (Biochem. J. 2009) 3 23
  4. RREB-1 is a transcriptional repressor of HLA-G. (PMID: 19890057) Flajollet S. … Moreau P. (J. Immunol. 2009) 3 23
  5. Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1. (PMID: 18394891) Melani M. … Montell D. (Curr. Biol. 2008) 2 3

Products for RREB1 Gene

Sources for RREB1 Gene

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