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RREB1 Gene

protein-coding   GIFtS: 59
GCID: GC06P007107

Ras Responsive Element Binding Protein 1

  See RREB1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ras Responsive Element Binding Protein 11 2     HNT2
Finger Protein In Nuclear Bodies2 3     LZ3212
Raf-Responsive Zinc Finger Protein LZ3212 3     DNA-Binding Protein2
Zinc Finger Motif Enhancer-Binding Protein 12 3     Hindsight Homolog2
FINB2 3     Ras-Responsive Element-Binding Protein 12
RREB-12 3     Zinc Finger Motif Enhancer Binding Protein 12
Zep-12 3     Zinc Finger Motif-Enhancer Binding-Protein 12
Hindsight Homolog (Drosophila)1     

External Ids:    HGNC: 104491   Entrez Gene: 62392   Ensembl: ENSG000001247827   OMIM: 6022095   UniProtKB: Q927663   

Export aliases for RREB1 gene to outside databases

Previous GC identifers: GC06P007092 GC06P007052 GC06P007053 GC06P007084 GC06P006984


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RREB1 Gene:
The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements
(RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the
encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated
cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this
gene. (provided by RefSeq, Dec 2009)

GeneCards Summary for RREB1 Gene:
RREB1 (ras responsive element binding protein 1) is a protein-coding gene. Diseases associated with RREB1 include substance-induced psychosis, and vulvar melanoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF821.

UniProtKB/Swiss-Prot: RREB1_HUMAN, Q92766
Function: Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. May
be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the
angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional
activity of NEUROD1

Gene Wiki entry for RREB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RREB1 gene promoter:
         GATA-3   ATF-2   Meis-1b   HNF-1A   GATA-2   N-Myc   AREB6   HNF-1   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRREB1 promoter sequence
   Search Chromatin IP Primers for RREB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RREB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25   Ensembl cytogenetic band:  6p24.3   HGNC cytogenetic band: 6p25

RREB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RREB1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P007107:  view genomic region     (about GC identifiers)

Start:
7,107,830 bp from pter      End:
7,252,213 bp from pter
Size:
144,384 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RREB1_HUMAN, Q92766 (See protein sequence)
Recommended Name: Ras-responsive element-binding protein 1  
Size: 1687 amino acids; 181420 Da
Subunit: Interacts with NEUROD1 and AR
Sequence caution: Sequence=AAB19094.1; Type=Frameshift; Positions=908, 1350, 1383; Sequence=AAC25598.1;
Type=Frameshift; Positions=1350, 1383; Sequence=AAC26118.1; Type=Frameshift; Positions=1350, 1383;
Sequence=AAH42910.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH42910.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA23165.1;
Type=Miscellaneous discrepancy; Note=Numerous sequencing errors; Sequence=CAH73521.1; Type=Erroneous initiation;
Secondary accessions: A2RRF5 E2GM80 E2GM81 O75567 O75568 Q5VYB2 Q6BEP5 Q6BEP6 Q6BEP8 Q86SU2
Q9Y474
Alternative splicing: 6 isoforms:  Q92766-1   Q92766-2   Q92766-3   Q92766-4   Q92766-5   Q92766-6   (Ref.7 (AAC26118) sequence differs from that shown due to a frameshift in position 1271)

Explore the universe of human proteins at neXtProt for RREB1: NX_Q92766

Explore proteomics data for RREB1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys435
  • Modification sites at PhosphoSitePlus

  • See RREB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001003698.1  NP_001003699.1  NP_001003700.1  NP_001161816.1  

    ENSEMBL proteins: 
     ENSP00000369265   ENSP00000420519   ENSP00000369270   ENSP00000420299   ENSP00000420571  
     ENSP00000335574   ENSP00000305560   ENSP00000419511  

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    antibodies-online peptides for RREB1

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    antibodies-online antibodies for RREB1 (22 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q92766

    ProtoNet protein and cluster: Q92766

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: RREB1_HUMAN, Q92766
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 15 C2H2-type zinc fingers


    Find genes that share domains with RREB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RREB1_HUMAN, Q92766
    Function: Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. May
    be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the
    angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional
    activity of NEUROD1

         Genatlas biochemistry entry for RREB1:
    RAS responsive element binding protein

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with RREB1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RREB1:
     Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RREB1

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for RREB1 (see all 272):
    AADACL4,  AARSD1,  ABR,  ACAD8,  ADAMTS18,  ANKRD40,  APLNR,  APOC2,  APOC4,  APOL1

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    miRTarBase miRNAs that target RREB1:
    hsa-mir-106b-5p (MIRT044319), hsa-mir-155-5p (MIRT021051), hsa-mir-671-5p (MIRT039263), hsa-mir-30d-5p (MIRT047790)

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    Selected qRT-PCR Assays for microRNAs that regulate RREB1 (see all 106):
    hsa-miR-582-3p hsa-miR-3678-3p hsa-miR-15a hsa-miR-199a-3p hsa-miR-128 hsa-miR-1245 hsa-miR-342-3p hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidRREB1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RREB1_HUMAN, Q92766: Nucleus speckle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS9305772
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm TAS9305772
    GO:0016604nuclear body TAS9305772
    GO:0016607nuclear speck IEA--

    Find genes that share ontologies with RREB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RREB1
    Interactions:

        GeneGlobe Interaction Network for RREB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for RREB1 (Q927663 ENSP000003692704) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    NEUROD1Q135623, ENSP000002951084I2D: score=1 STRING: ENSP00000295108
    CTBP1Q133633, ENSP000002909214I2D: score=1 STRING: ENSP00000290921
    KDM1AO603413, ENSP000003490494I2D: score=1 STRING: ENSP00000349049
    HIST3H3Q166953, ENSP000003556574I2D: score=1 STRING: ENSP00000355657
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated TAS9305772
    GO:0006366transcription from RNA polymerase II promoter TAS8816445
    GO:0007265Ras protein signal transduction TAS8816445
    GO:0007275multicellular organismal development TAS8816445
    GO:0045892negative regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with RREB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RREB1

    1 HMDB Compound for RREB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--

    1 Novoseek inferred chemical compound relationship for RREB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 57.4 8 9427563 (3), 8816445 (2), 17550981 (1), 18190854 (1)



    Find genes that share compounds with RREB1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RREB1 gene (5 alternative transcripts): 
    NM_001003698.3  NM_001003699.3  NM_001003700.1  NM_001168344.1  NM_002955.4  

    Unigene Cluster for RREB1:

    Ras responsive element binding protein 1
    Hs.298248  [show with all ESTs]
    Unigene Representative Sequence: NM_001003699
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379933 ENST00000491191 ENST00000379938(uc021yky.1 uc010jnw.3 uc003mxb.3 uc003mxc.3 uc010jnx.3 uc021ykz.1 uc021yla.1)
    ENST00000471433 ENST00000467782 ENST00000334984 ENST00000349384 ENST00000475946(uc003mxd.3)
    ENST00000483150
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    hsa-miR-582-3p hsa-miR-3678-3p hsa-miR-15a hsa-miR-199a-3p hsa-miR-128 hsa-miR-1245 hsa-miR-342-3p hsa-miR-3916
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    Additional mRNA sequence: 

    AB019254.1 AB019351.1 AB019352.1 AF072825.1 AF072826.1 BC032062.1 BC042910.2 BC111386.1 
    BC131599.1 D49835.1 U26914.1 

    18 DOTS entries:

    DT.92430880  DT.100036523  DT.95177528  DT.100766832  DT.100748175  DT.105872  DT.121328334  DT.121328471 
    DT.100808521  DT.214641  DT.101965501  DT.121328469  DT.40204066  DT.75169201  DT.91667030  DT.91698760 
    DT.91876505  DT.95254815 

    Selected AceView cDNA sequences (see all 231):

    BX955992 BP366145 BC032062 AA256198 AI587262 AW139366 AI679131 AI446278 
    BF475814 BM699086 AA102122 BU859660 NM_002955 AA515213 AA856743 AI278685 
    NM_001003699 AW469442 CB144053 BF901096 AI361819 CA942427 BI826215 BU538534 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RREB1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                    -                                         -                                 
    SP2:                    -                                         -                       -         
    SP3:                    -                                         -                 -               
    SP4:                                                                                                
    SP5:                    -                                                                           


    ECgene alternative splicing isoforms for RREB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RREB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACAGACATA
    RREB1 Expression
    About this image


    RREB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Brain (Nervous System)
             Hypothalamus
     
     Dermis (Integumentary System)
    RREB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RREB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.298248

    UniProtKB/Swiss-Prot: RREB1_HUMAN, Q92766
    Tissue specificity: Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not found in
    the brain

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RREB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RREB1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rreb11 , 5 ras responsive element binding protein 11, 5 82.01(n)1
    81.32(a)1
      13 (17.70 cM)5
    687501  NM_001177869.11  NP_001171340.11 
     377784005 
    chicken
    (Gallus gallus)
    Aves RREB11 ras responsive element binding protein 1 68.91(n)
    67.79(a)
      395920  NM_205049.1  NP_990380.1 
    lizard
    (Anolis carolinensis)
    Reptilia RREB16
    ras responsive element binding protein 1
    62(a)
    1 ↔ 1
    GL343311.1(150147-225251)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.53872 Xenopus laevis transcribed sequence with weak similarity more 77.9(n)    48043480 
    zebrafish
    (Danio rerio)
    Actinopterygii BG985521.12   -- 76.3(n)   338237  BG985521.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta peb6
    pebbled
    18(a)
    1 → many
    X(4511602-4520256)


    ENSEMBL Gene Tree for RREB1 (if available)
    TreeFam Gene Tree for RREB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RREB1 gene
    ZNF8212  
    Selected SIMAP similar genes for RREB1 using alignment to 4 protein entries:     RREB1_HUMAN (see all proteins) (see all similar genes):
    ZSCAN9    ZNF55    ZFS-4    GZF1    ZNF7    ZNF26
    ZFS-5    ZNF213    ZNF562    ZNF    A-328A3.4    ZNF420
    ZNF78L1    ZFP64    ZNF702P    ZNF384    ZNF544    ZNF671

    Find genes that share paralogs with RREB1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RREB1
    PGOHUM00000243480


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RREB1 (see all 3083)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs588912331,2
    C--7002537(+) TGTTTGTTT/-  
            
    TGAGA
    4 -- int11Minor allele frequency- -:0.00NA 2
    rs733726441,2
    C--7034867(+) ACCTAT/CTCTAT 4 -- us2k12Minor allele frequency- C:0.14WA 120
    rs762331721,2
    C,F--7034895(+) TTATTC/TCTGTC 4 -- us2k12Minor allele frequency- T:0.05NA EA 240
    rs1477029791,2
    --7034929(+) CGACTA/GGCCTG 4 -- us2k10--------
    rs1840851851,2
    --7034979(+) GGGTTA/GGGGGA 4 -- us2k10--------
    rs797024461,2
    F--7034990(+) GGCTCA/CGAAAA 4 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1870802481,2
    --7034993(+) TCAGAA/CAAATG 4 -- us2k10--------
    rs28428951,2
    C,F,A,H--7035064(+) TAACAG/CGTTCC 4 -- us2k112Minor allele frequency- C:0.30NS EA NA 730
    rs1379890761,2
    C--7035145(+) TAGCC-/TTACTT 4 -- us2k10--------
    rs1911811591,2
    --7035339(+) AGAGGA/GGCTGG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for RREB1 (7107830 - 7252213 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RREB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv818397CNV Loss17921354
    nsv883432CNV Loss21882294
    nsv883430CNV Gain21882294
    nsv823411CNV Gain20364138
    nsv883431CNV Gain21882294

    Human Gene Mutation Database (HGMD): RREB1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RREB1
    DNA2.0 Custom Variant and Variant Library Synthesis for RREB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602209    OMIM disorders: --

    2 diseases for RREB1:    
    About MalaCards
    substance-induced psychosis    vulvar melanoma

    3 diseases from the University of Copenhagen DISEASES database for RREB1:
    Vulvar melanoma     substance-induced psychosis     Melanoma

    Find genes that share disorders with RREB1           About GenesLikeMe

    1 Novoseek inferred disease relationship for RREB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid carcinoma medullary 59.6 3 8816445 (2), 9427563 (1)

    Genetic Association Database (GAD): RREB1
    Human Genome Epidemiology (HuGE) Navigator: RREB1 (4 documents)

    Export disorders for RREB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RREB1 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with RREB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The zinc finger protein Ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer. (PubMed id 17550981)1, 2, 9 Mukhopadhyay N.K.... Freeman M.R. (Mol. Endocrinol. 2007)
    2. RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas. (PubMed id 8816445)1, 2, 9 Thiagalingam A.... Nelkin B.D. (Mol. Cell. Biol. 1996)
    3. A human Raf-responsive zinc-finger protein that binds to divergent sequences. (PubMed id 10390538)1, 2, 9 Zhang L.... Edenberg H.J. (Nucleic Acids Res. 1999)
    4. Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1. (PubMed id 12482979)1, 2, 9 Ray S.K.... Leiter A.B. (Mol. Cell. Biol. 2003)
    5. RREB1 Transcription Factor Splice Variants in Urologic Cancer. (PubMed id 21703425)1, 2 Nitz M.D.... Theodorescu D. (Am. J. Pathol. 2011)
    6. Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). (PubMed id 20385826)1, 4 Neale B.M....Seddon J.M. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1. (PubMed id 18394891)1, 3 Melani M....Montell D. (Curr. Biol. 2008)
    9. Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene. (PubMed id 15067362)1, 2 Date S.... Fukamizu A. (Int. J. Mol. Med. 2004)
    10. RREB1, a ras responsive element binding protein, maps to human chromosome 6p25. (PubMed id 9367691)1, 3 Thiagalingam A....Nelkin B.D. (Genomics 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6239 HGNC: 10449 AceView: RREB1 Ensembl:ENSG00000124782 euGenes: HUgn6239
    ECgene: RREB1 H-InvDB: RREB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RREB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RREB1 gene:
    Search GeneIP for patents involving RREB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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