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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RREB1 Gene

protein-coding   GIFtS: 57
GCID: GC06P007084

Ras Responsive Element Binding Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ras Responsive Element Binding Protein 11 2     HNT2
Finger Protein In Nuclear Bodies2 3     LZ3212
Raf-Responsive Zinc Finger Protein LZ3212 3     DNA-Binding Protein2
Zinc Finger Motif Enhancer-Binding Protein 12 3     Hindsight Homolog2
FINB2 3     Ras-Responsive Element-Binding Protein 12
RREB-12 3     Zinc Finger Motif Enhancer Binding Protein 12
Zep-12 3     Zinc Finger Motif-Enhancer Binding-Protein 12
Hindsight Homolog (Drosophila)1     

External Ids:    HGNC: 104491   Entrez Gene: 62392   Ensembl: ENSG000001247827   OMIM: 6022095   UniProtKB: Q927663   

Export aliases for RREB1 gene to outside databases

Previous GC identifers: GC06P007092 GC06P007052 GC06P007053 GC06P006984


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RREB1 Gene:
The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements
(RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the
encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated
cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this
gene. (provided by RefSeq, Dec 2009)

GeneCards Summary for RREB1 Gene: 
RREB1 (ras responsive element binding protein 1) is a protein-coding gene. Diseases associated with RREB1 include substance-induced psychosis, and malignant spindle cell melanoma. GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF821.

UniProtKB/Swiss-Prot: RREB1_HUMAN, Q92766
Function: Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. May
be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the
angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional
activity of NEUROD1

Gene Wiki entry for RREB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RREB1 gene promoter:
         GATA-3   ATF-2   Meis-1b   HNF-1A   GATA-2   N-Myc   AREB6   HNF-1   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRREB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RREB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RREB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25   Ensembl cytogenetic band:  6p24.3   HGNC cytogenetic band: 6p25

RREB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RREB1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P007084:  view genomic region     (about GC identifiers)

Start:
7,107,830 bp from pter      End:
7,252,213 bp from pter
Size:
144,384 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RREB1_HUMAN, Q92766 (See protein sequence)
Recommended Name: Ras-responsive element-binding protein 1  
Size: 1687 amino acids; 181420 Da
Subunit: Interacts with NEUROD1 and AR
Subcellular location: Nucleus speckle
Sequence caution: Sequence=AAB19094.1; Type=Frameshift; Positions=908, 1350, 1383; Sequence=AAC25598.1;
Type=Frameshift; Positions=1350, 1383; Sequence=AAC26118.1; Type=Frameshift; Positions=1350, 1383;
Sequence=AAH42910.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH42910.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA23165.1;
Type=Miscellaneous discrepancy; Note=Numerous sequencing errors; Sequence=CAH73521.1; Type=Erroneous initiation;
Secondary accessions: A2RRF5 O75567 O75568 Q5VYB2 Q6BEP5 Q6BEP6 Q6BEP8 Q86SU2 Q9Y474
Alternative splicing: 4 isoforms:  Q92766-1   Q92766-2   Q92766-3   Q92766-4   (Ref.6 (AAC26118) sequence differs from that shown due to a frameshift in position 1271)

Explore the universe of human proteins at neXtProt for RREB1: NX_Q92766

Explore proteomics data for RREB1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92766

  • RREB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RREB1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001003698.1  NP_001003699.1  NP_001003700.1  NP_001161816.1  

    ENSEMBL proteins: 
     ENSP00000369265   ENSP00000420519   ENSP00000369270   ENSP00000420299   ENSP00000420571  
     ENSP00000335574   ENSP00000305560   ENSP00000419511  

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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS9305772
    GO:0005737cytoplasm TAS9305772
    GO:0016604nuclear body TAS9305772
    GO:0016607nuclear speck IEA--

    RREB1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q92766

    ProtoNet protein and cluster: Q92766

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: RREB1_HUMAN, Q92766
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 15 C2H2-type zinc fingers


    RREB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RREB1_HUMAN, Q92766
    Function: Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. May
    be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the
    angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional
    activity of NEUROD1

         Genatlas biochemistry entry for RREB1:
    RAS responsive element binding protein

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    RREB1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RREB1:
     Synthetic lethal with Ras 

    Animal Models:
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    10/276 SABiosciences Target genes for RREB1 (see all 276):
    AADACL4 AARSD1 ABR ACAD8 ADAMTS18 ANKRD40 APLNR APOC2 APOC4 APOL1

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RREB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for RREB1 (Q927663 ENSP000003692704) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    NEUROD1Q135623, ENSP000002951084I2D: score=1 STRING: ENSP00000295108
    CTBP1Q133633, ENSP000002909214I2D: score=1 STRING: ENSP00000290921
    KDM1AO603413, ENSP000003490494I2D: score=1 STRING: ENSP00000349049
    HIST3H3Q166953, ENSP000003556574I2D: score=1 STRING: ENSP00000355657
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent TAS9305772
    GO:0006366transcription from RNA polymerase II promoter TAS8816445
    GO:0007265Ras protein signal transduction TAS8816445
    GO:0007275multicellular organismal development TAS8816445
    GO:0045892negative regulation of transcription, DNA-dependent IEA--

    RREB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RREB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RREB1

    1 HMDB Compound for RREB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--

    1 Novoseek inferred chemical compound relationship for RREB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 57.4 8 9427563 (3), 8816445 (2), 17550981 (1), 18190854 (1)

    Search CenterWatch for drugs/clinical trials and news about RREB1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for RREB1 gene (5 alternative transcripts): 
    NM_001003698.3  NM_001003699.3  NM_001003700.1  NM_001168344.1  NM_002955.4  

    Unigene Cluster for RREB1:

    Ras responsive element binding protein 1
    Hs.298248  [show with all ESTs]
    Unigene Representative Sequence: NM_001003699
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379933 ENST00000491191 ENST00000379938(uc021yky.1 uc010jnw.3 uc003mxb.3 uc003mxc.3 uc010jnx.3 uc021ykz.1 uc021yla.1)
    ENST00000471433 ENST00000467782 ENST00000334984 ENST00000349384 ENST00000475946(uc003mxd.3)
    ENST00000483150
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    Additional mRNA sequence: 

    AB019254.1 AB019351.1 AB019352.1 AF072825.1 AF072826.1 BC032062.1 BC042910.2 BC111386.1 
    BC131599.1 D49835.1 U26914.1 

    18 DOTS entries:

    DT.92430880  DT.100036523  DT.95177528  DT.100766832  DT.100748175  DT.105872  DT.121328334  DT.121328471 
    DT.100808521  DT.214641  DT.101965501  DT.121328469  DT.40204066  DT.75169201  DT.91667030  DT.91698760 
    DT.91876505  DT.95254815 

    24/231 AceView cDNA sequences (see all 231):

    AA102122 BM699086 BF475814 AI446278 AI679131 AW139366 AI587262 AA256198 
    BC032062 CB119436 BX490281 AW664054 CA433872 AI587271 AA490817 AI982841 
    BM666049 BF718462 AW475053 AA968736 BM914100 AI088091 NM_001003698 AW778741 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RREB1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                    -                                         -                                 
    SP2:                    -                                         -                       -         
    SP3:                    -                                         -                 -               
    SP4:                                                                                                
    SP5:                    -                                                                           


    ECgene alternative splicing isoforms for RREB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RREB1 expression in normal human tissues (normalized intensities)      RREB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACAGACATA
    RREB1 Expression
    About this image


    RREB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Hypothalamus
             brain/forebrain/diencephalon   
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Epidermis (Integumentary System)
     
     Dermis (Integumentary System)

    See RREB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RREB1

    SOURCE GeneReport for Unigene cluster: Hs.298248

    UniProtKB/Swiss-Prot: RREB1_HUMAN, Q92766
    Tissue specificity: Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not found in
    the brain

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RREB1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rreb11 , 5 ras responsive element binding protein 11, 5 82.15(n)1
    81.78(a)1
      13 (17.70 cM)5
    687501  NM_001177869.11  NP_001171340.11 
     377784005 
    chicken
    (Gallus gallus)
    Aves RREB11 ras responsive element binding protein 1 68.78(n)
    68.15(a)
      395920  NM_205049.1  NP_990380.1 
    lizard
    (Anolis carolinensis)
    Reptilia RREB16
    ras responsive element binding protein 1
    62(a)
    1 ↔ 1
    GL343311.1(150147-225251)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.53872 Xenopus laevis transcribed sequence with weak similarity more 77.9(n)    48043480 
    zebrafish
    (Danio rerio)
    Actinopterygii BG985521.12   -- 76.3(n)   338237  BG985521.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta peb6
    pebbled
    16(a)
    1 ↔ 1
    X(4511602-4520256)


    ENSEMBL Gene Tree for RREB1 (if available)
    TreeFam Gene Tree for RREB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RREB1 gene
    ZNF8212  
    18/115 SIMAP similar genes for RREB1 using alignment to 6 protein entries:     RREB1_HUMAN (see all proteins) (see all similar genes):
    ZSCAN9    ZNF55    ZFS-4    GZF1    ZNF7    ZNF26
    ZFS-5    ZNF213    ZNF219    ZNF562    ZNF    ZNF78L1
    ZNF420    ZFP64    A-328A3.4    ZNF702P    ZNF384    ZNF544

    RREB1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RREB1
    PGOHUM00000243480


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3083 SNPs in RREB1 are shown (see all 3083)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs588912331,2
    C--7002537(+) TGTTTGTTT/-  
            
    TGAGA
    4 -- int11Minor allele frequency- -:0.00NA 2
    rs733726441,2
    C--7034867(+) ACCTAT/CTCTAT 4 -- us2k12Minor allele frequency- C:0.14WA 120
    rs762331721,2
    C,F--7034895(+) TTATTC/TCTGTC 4 -- us2k12Minor allele frequency- T:0.05NA EA 240
    rs1477029791,2
    --7034929(+) CGACTA/GGCCTG 4 -- us2k10--------
    rs1840851851,2
    --7034979(+) GGGTTA/GGGGGA 4 -- us2k10--------
    rs797024461,2
    F--7034990(+) GGCTCA/CGAAAA 4 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1870802481,2
    --7034993(+) TCAGAA/CAAATG 4 -- us2k10--------
    rs28428951,2
    C,F,A,H--7035064(+) TAACAG/CGTTCC 4 -- us2k112Minor allele frequency- C:0.30NS EA NA 730
    rs1379890761,2
    C--7035145(+) TAGCC-/TTACTT 4 -- us2k10--------
    rs1911811591,2
    --7035339(+) AGAGGA/GGCTGG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for RREB1 (7107830 - 7252213 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RREB1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv818397CNV Loss17921354
    nsv883432CNV Loss21882294
    nsv883430CNV Gain21882294
    nsv823411CNV Gain20364138
    nsv883431CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602209    OMIM disorders: --

    14 diseases for RREB1:    About MalaCards
    substance-induced psychosis    malignant spindle cell melanoma    cardiovascular disease risk factor )    gout
    macular degeneration    age related macular degeneration    thyroiditis    melanoma
    multiple sclerosis    prostate cancer    adenocarcinoma    prostatitis
    pancreatitis    hepatitis

    3 diseases from the University of Copenhagen DISEASES database for RREB1:
    Vulvar melanoma     substance-induced psychosis     Melanoma

    RREB1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for RREB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid carcinoma medullary 59.6 3 8816445 (2), 9427563 (1)

    Genetic Association Database (GAD): RREB1
    Human Genome Epidemiology (HuGE) Navigator: RREB1 (4 documents)

    Export disorders for RREB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RREB1 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with RREB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The zinc finger protein Ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer. (PubMed id 17550981)1, 2, 9 Mukhopadhyay N.K.... Freeman M.R. (2007)
    2. RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas. (PubMed id 8816445)1, 2, 9 Thiagalingam A.... Nelkin B.D. (1996)
    3. A human Raf-responsive zinc-finger protein that binds to divergent sequences. (PubMed id 10390538)1, 2, 9 Zhang L.... Edenberg H.J. (1999)
    4. Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1. (PubMed id 12482979)1, 2, 9 Ray S.K.... Leiter A.B. (2003)
    5. Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). (PubMed id 20385826)1, 4 Neale B.M....Seddon J.M. (2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. Regulation of cell adhesion and collective cell migra tion by hindsight and its human homolog RREB1. (PubMed id 18394891)1, 3 Melani M....Montell D. (2008)
    8. Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene. (PubMed id 15067362)1, 2 Date S.... Fukamizu A. (2004)
    9. RREB1, a ras responsive element binding protein, maps to human chromosome 6p25. (PubMed id 9367691)1, 3 Thiagalingam A....Nelkin B.D. (1997)
    10. A novel zinc finger protein, Finb, is a transcriptional activator and localized in nuclear bodies. (PubMed id 9305772)1, 2 Fujimoto-Nishiyama A.... Yamamoto T. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6239 HGNC: 10449 AceView: RREB1 Ensembl:ENSG00000124782 euGenes: HUgn6239
    ECgene: RREB1 H-InvDB: RREB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RREB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RREB1 gene:
    Search GeneIP for patents involving RREB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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