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Aliases for RRBP1 Gene

Aliases for RRBP1 Gene

  • Ribosome Binding Protein 1 2 3 5
  • Ribosome Binding Protein 1 Homolog 180kDa (Dog) 2 3
  • 180 KDa Ribosome Receptor Homolog 3 4
  • Ribosome Receptor Protein 3 4
  • ES/130-Related Protein 3 4
  • RRP 3 4
  • Ribosome Binding Protein 1 (Dog 180kD Homolog) 2
  • Ribosome-Binding Protein 1 3
  • KIAA1398 4
  • ES/130 3
  • ES130 3
  • HES 3

External Ids for RRBP1 Gene

Previous GeneCards Identifiers for RRBP1 Gene

  • GC20M017582
  • GC20M017589
  • GC20M017542
  • GC20M017594
  • GC20M017557

Summaries for RRBP1 Gene

Entrez Gene Summary for RRBP1 Gene

  • This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12. [provided by RefSeq, Apr 2012]

GeneCards Summary for RRBP1 Gene

RRBP1 (Ribosome Binding Protein 1) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and Ectoderm Differentiation. GO annotations related to this gene include poly(A) RNA binding and receptor activity. An important paralog of this gene is KTN1.

UniProtKB/Swiss-Prot for RRBP1 Gene

  • Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.

Gene Wiki entry for RRBP1 Gene

Additional gene information for RRBP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRBP1 Gene

Genomics for RRBP1 Gene

Regulatory Elements for RRBP1 Gene

Enhancers for RRBP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H017556 1.8 FANTOM5 Ensembl ENCODE dbSUPER 21 +123.4 123445 5.4 ELF3 TBP PKNOX1 FOXA2 SIN3A DNMT3B ZSCAN9 RAD21 RARA SLC30A9 RRBP1 DSTN GCNT1P1 ENSG00000277373 GC20P017516
GH20H017858 2.1 VISTA FANTOM5 Ensembl ENCODE dbSUPER 12.5 -177.3 -177287 2.2 FOXA2 ATF1 MLX ZFP64 ARID4B DMAP1 YY1 TCF12 SLC30A9 ATF7 RRBP1 BANF2 SNX5 MGME1 GC20M017851 LOC105372548
GH20H017609 1.6 FANTOM5 Ensembl ENCODE dbSUPER 15.1 +69.4 69444 7 CTCF KLF1 ZFP64 MAX FEZF1 CHD7 ZIC2 THRB RAD21 E2F1 DSTN RRBP1 LOC100286962 PIR41690
GH20H017566 1.3 ENCODE dbSUPER 18.1 +112.1 112051 6.5 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF143 RRBP1 DSTN ZNF133 POLR3F BANF2 BFSP1 RN7SKP69 GC20M017577
GH20H017894 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -213.8 -213811 2.6 FOXA2 ATF1 ARID4B DMAP1 TCF12 SLC30A9 ATF7 RUNX3 SP5 ZHX2 RRBP1 BANF2 ENSG00000233625 RNU6-192P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RRBP1 on UCSC Golden Path with GeneCards custom track

Promoters for RRBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for RRBP1 Gene

Genomic Locations for RRBP1 Gene
68,618 bases
Minus strand

Genomic View for RRBP1 Gene

Genes around RRBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRBP1 Gene

Proteins for RRBP1 Gene

  • Protein details for RRBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribosome-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • A2A2S6
    • A6NCN6
    • O75300
    • O75301
    • Q5W165
    • Q96SB2
    • Q9BWP1
    • Q9H476

    Protein attributes for RRBP1 Gene

    1410 amino acids
    Molecular mass:
    152472 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA92636.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RRBP1 Gene


neXtProt entry for RRBP1 Gene

Post-translational modifications for RRBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RRBP1 Gene

Domains & Families for RRBP1 Gene

Gene Families for RRBP1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for RRBP1 Gene


Suggested Antigen Peptide Sequences for RRBP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RRBP1: view

No data available for UniProtKB/Swiss-Prot for RRBP1 Gene

Function for RRBP1 Gene

Molecular function for RRBP1 Gene

GENATLAS Biochemistry:
ribosome binding protein 1
UniProtKB/Swiss-Prot Function:
Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.

Phenotypes From GWAS Catalog for RRBP1 Gene

Gene Ontology (GO) - Molecular Function for RRBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
GO:0004872 receptor activity TAS 9628588
genes like me logo Genes that share ontologies with RRBP1: view
genes like me logo Genes that share phenotypes with RRBP1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRBP1 Gene

Localization for RRBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRBP1 Gene

Endoplasmic reticulum membrane; Single-pass type III membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRBP1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RRBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005840 ribosome TAS 9628588
GO:0016020 membrane IEA,IDA 16210410
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RRBP1: view

Pathways & Interactions for RRBP1 Gene

genes like me logo Genes that share pathways with RRBP1: view

Pathways by source for RRBP1 Gene

1 BioSystems pathway for RRBP1 Gene
1 KEGG pathway for RRBP1 Gene

Gene Ontology (GO) - Biological Process for RRBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006412 translation TAS 9628588
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with RRBP1: view

No data available for SIGNOR curated interactions for RRBP1 Gene

Drugs & Compounds for RRBP1 Gene

No Compound Related Data Available

Transcripts for RRBP1 Gene

Unigene Clusters for RRBP1 Gene

Ribosome binding protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RRBP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - -
SP2: - - -
SP4: -
SP6: -
SP8: - - - - - - - -
SP10: -
SP12: -

ExUns: 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28a · 28b · 28c
SP1: -
SP2: -
SP3: -

Relevant External Links for RRBP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RRBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RRBP1 Gene

mRNA differential expression in normal tissues according to GTEx for RRBP1 Gene

This gene is overexpressed in Pancreas (x6.3).

Protein differential expression in normal tissues from HIPED for RRBP1 Gene

This gene is overexpressed in Liver, secretome (21.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RRBP1 Gene

Protein tissue co-expression partners for RRBP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RRBP1 Gene:


SOURCE GeneReport for Unigene cluster for RRBP1 Gene:


Evidence on tissue expression from TISSUES for RRBP1 Gene

  • Nervous system(4.7)
  • Liver(4.6)
  • Intestine(3.7)
  • Pancreas(3.5)
  • Lung(3.3)
  • Blood(2.9)
  • Heart(2.7)
  • Kidney(2.7)
  • Eye(2.2)
  • Stomach(2.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with RRBP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RRBP1 Gene

Orthologs for RRBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RRBP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RRBP1 33 34
  • 99.15 (n)
(Monodelphis domestica)
Mammalia RRBP1 34
  • 70 (a)
(Canis familiaris)
Mammalia RRBP1 34
  • 58 (a)
(Mus musculus)
Mammalia Rrbp1 34
  • 56 (a)
(Bos Taurus)
Mammalia RRBP1 34
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia RRBP1 34
  • 42 (a)
(Gallus gallus)
Aves RRBP1 34
  • 57 (a)
(Anolis carolinensis)
Reptilia RRBP1 34
  • 43 (a)
(Danio rerio)
Actinopterygii rrbp1b 34
  • 34 (a)
rrbp1a 34
  • 30 (a)
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13657 33
Species where no ortholog for RRBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RRBP1 Gene

Gene Tree for RRBP1 (if available)
Gene Tree for RRBP1 (if available)

Paralogs for RRBP1 Gene

Paralogs for RRBP1 Gene

(1) SIMAP similar genes for RRBP1 Gene using alignment to 9 proteins: Pseudogenes for RRBP1 Gene

genes like me logo Genes that share paralogs with RRBP1: view

Variants for RRBP1 Gene

Sequence variations from dbSNP and Humsavar for RRBP1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000026925 -- 17,648,847(+) CCCAA(A/G)GCACA intron-variant
rs1000033382 -- 17,676,108(+) GGAGG(A/C)TGAGG intron-variant
rs1000038609 -- 17,682,807(+) CGGGC(A/C)GCCGG upstream-variant-2KB
rs1000085264 -- 17,675,854(+) TAGAA(A/G)GCAGG intron-variant
rs1000119593 -- 17,653,693(+) GCTGG(A/G)CGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RRBP1 Gene

Variant ID Type Subtype PubMed ID
nsv952994 CNV deletion 24416366
nsv952993 CNV deletion 24416366
nsv828695 CNV gain 20364138
nsv585662 CNV loss 21841781
nsv527274 CNV loss 19592680
nsv519542 CNV loss 19592680
nsv458943 CNV loss 19166990
nsv3311 CNV insertion 18451855
nsv180652 CNV deletion 16902084
nsv1143978 CNV deletion 24896259
nsv1073048 CNV deletion 25765185
esv23450 CNV gain 19812545
esv1521395 CNV insertion 17803354

Variation tolerance for RRBP1 Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.55; 97.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRBP1 Gene

Disorders for RRBP1 Gene

Relevant External Links for RRBP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RRBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRBP1 Gene

Publications for RRBP1 Gene

  1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 60
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D … Nagase T (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 3 4 60
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 60

Products for RRBP1 Gene

Sources for RRBP1 Gene

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