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Aliases for RRBP1 Gene

Aliases for RRBP1 Gene

  • Ribosome Binding Protein 1 2 3
  • Ribosome Binding Protein 1 Homolog 180kDa (Dog) 2 3
  • 180 KDa Ribosome Receptor Homolog 3 4
  • Ribosome Receptor Protein 3 4
  • ES/130-Related Protein 3 4
  • ES130 3 6
  • RRP 3 4
  • Ribosome Binding Protein 1 (Dog 180kD Homolog) 2
  • Ribosome-Binding Protein 1 3
  • KIAA1398 4
  • ES/130 3
  • HES 3

External Ids for RRBP1 Gene

Summaries for RRBP1 Gene

Entrez Gene Summary for RRBP1 Gene

  • This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12. [provided by RefSeq, Apr 2012]

GeneCards Summary for RRBP1 Gene

RRBP1 (Ribosome Binding Protein 1) is a Protein Coding gene. Diseases associated with RRBP1 include anuria. Among its related pathways are Protein processing in endoplasmic reticulum. GO annotations related to this gene include receptor activity. An important paralog of this gene is KTN1.

UniProtKB/Swiss-Prot for RRBP1 Gene

  • Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.

Gene Wiki entry for RRBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRBP1 Gene

Genomics for RRBP1 Gene

Genomic Location for RRBP1 Gene

Start:
17,613,678 bp from pter
End:
17,682,295 bp from pter
Size:
68,618 bases
Orientation:
Minus strand

Genomic View for RRBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RRBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRBP1 Gene

Regulatory Elements for RRBP1 Gene

Proteins for RRBP1 Gene

  • Protein details for RRBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2E9-RRBP1_HUMAN
    Recommended name:
    Ribosome-binding protein 1
    Protein Accession:
    Q9P2E9
    Secondary Accessions:
    • A2A2S6
    • A6NCN6
    • O75300
    • O75301
    • Q5W165
    • Q96SB2
    • Q9BWP1
    • Q9H476

    Protein attributes for RRBP1 Gene

    Size:
    1410 amino acids
    Molecular mass:
    152472 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92636.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RRBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RRBP1 Gene

Proteomics data for RRBP1 Gene at MOPED

Post-translational modifications for RRBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RRBP1 Gene

Domains for RRBP1 Gene

Protein Domains for RRBP1 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with RRBP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for RRBP1 Gene

Function for RRBP1 Gene

Molecular function for RRBP1 Gene

GENATLAS Biochemistry: ribosome binding protein 1
UniProtKB/Swiss-Prot Function: Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.

Gene Ontology (GO) - Molecular Function for RRBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9628588
GO:0005515 protein binding --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with RRBP1: view

Phenotypes for RRBP1 Gene

GenomeRNAi human phenotypes for RRBP1:
genes like me logo Genes that share phenotypes with RRBP1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RRBP1 Gene

Localization for RRBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRBP1 Gene

Endoplasmic reticulum membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RRBP1 Gene COMPARTMENTS Subcellular localization image for RRBP1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2

Gene Ontology (GO) - Cellular Components for RRBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005840 ribosome TAS 9628588
GO:0016020 membrane IDA 16210410
GO:0030176 integral component of endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with RRBP1: view

Pathways for RRBP1 Gene

genes like me logo Genes that share pathways with RRBP1: view

Pathways by source for RRBP1 Gene

1 KEGG pathway for RRBP1 Gene

Gene Ontology (GO) - Biological Process for RRBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006412 translation TAS 9628588
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with RRBP1: view

Transcripts for RRBP1 Gene

Unigene Clusters for RRBP1 Gene

Ribosome binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RRBP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - -
SP2: - - -
SP3:
SP4: -
SP5:
SP6: -
SP7:
SP8: - - - - - - - -
SP9:
SP10: -
SP11:
SP12: -
SP13:

ExUns: 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28a · 28b · 28c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for RRBP1 Gene

GeneLoc Exon Structure for
RRBP1
ECgene alternative splicing isoforms for
RRBP1

Expression for RRBP1 Gene

mRNA expression in normal human tissues for RRBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RRBP1 Gene

This gene is overexpressed in Pancreas (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RRBP1 Gene

SOURCE GeneReport for Unigene cluster for RRBP1 Gene Hs.472213

genes like me logo Genes that share expressions with RRBP1: view

Orthologs for RRBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RRBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RRBP1 36
  • 99.15 (n)
  • 99.18 (a)
RRBP1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RRBP1 37
  • 48 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RRBP1 37
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rrbp1 16
Rrbp1 37
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RRBP1 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RRBP1 37
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves RRBP1 37
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RRBP1 37
  • 43 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13657 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
rrbp1a 37
  • 30 (a)
OneToMany
rrbp1b 37
  • 34 (a)
OneToMany
Species with no ortholog for RRBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RRBP1 Gene

ENSEMBL:
Gene Tree for RRBP1 (if available)
TreeFam:
Gene Tree for RRBP1 (if available)

Paralogs for RRBP1 Gene

Paralogs for RRBP1 Gene

Selected SIMAP similar genes for RRBP1 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for RRBP1 Gene

genes like me logo Genes that share paralogs with RRBP1: view

Variants for RRBP1 Gene

Sequence variations from dbSNP and Humsavar for RRBP1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs6599 -- 17,619,499(+) GCTTC(A/G)GGCAA intron-variant
rs8803 -- 17,614,156(-) AGTTA(C/T)TGTTC utr-variant-3-prime
rs9768 -- 17,619,377(+) TCAAA(C/T)GCCTC intron-variant
rs11960 -- 17,619,712(-) CACGT(C/T)GCATT reference, missense
rs12230 -- 17,619,587(+) GGACC(A/G)CAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RRBP1 Gene

Variant ID Type Subtype PubMed ID
dgv4556n71 CNV Loss 21882294
nsv3311 CNV Insertion 18451855
nsv458943 CNV Loss 19166990
esv23450 CNV Gain 19812545
nsv519542 CNV Loss 19592680
dgv4557n71 CNV Loss 21882294
nsv527274 CNV Loss 19592680
nsv828695 CNV Gain 20364138
esv1521395 CNV Insertion 17803354
nsv180652 CNV Loss 16902084

Relevant External Links for RRBP1 Gene

HapMap Linkage Disequilibrium report
RRBP1

Disorders for RRBP1 Gene

(1) MalaCards Diseases for RRBP1 Gene

Search for RRBP1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for RRBP1 Gene

genes like me logo Genes that share disorders with RRBP1: view

No data available for UniProtKB/Swiss-Prot for RRBP1 Gene

Publications for RRBP1 Gene

  1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  3. Identification, characterization, and chromosomal localization of the human homolog (hES) of ES/130. (PMID: 8812507) Basson C.T. … Seidman C.E. (Genomics 1996) 2 3
  4. Identification of multiple forms of 180-kDa ribosome receptor in human cells. (PMID: 9628588) Langley R. … Krissansen G.W. (DNA Cell Biol. 1998) 3 4
  5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4

Products for RRBP1 Gene

Sources for RRBP1 Gene

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