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Aliases for RRBP1 Gene

Aliases for RRBP1 Gene

  • Ribosome Binding Protein 1 2 3 5
  • Ribosome Binding Protein 1 Homolog 180kDa (Dog) 2 3
  • 180 KDa Ribosome Receptor Homolog 3 4
  • Ribosome Receptor Protein 3 4
  • ES/130-Related Protein 3 4
  • RRP 3 4
  • Ribosome Binding Protein 1 (Dog 180kD Homolog) 2
  • KIAA1398 4
  • ES/130 3
  • ES130 3
  • HES 3

External Ids for RRBP1 Gene

Previous GeneCards Identifiers for RRBP1 Gene

  • GC20M017582
  • GC20M017589
  • GC20M017542
  • GC20M017594
  • GC20M017557

Summaries for RRBP1 Gene

Entrez Gene Summary for RRBP1 Gene

  • This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12. [provided by RefSeq, Apr 2012]

GeneCards Summary for RRBP1 Gene

RRBP1 (Ribosome Binding Protein 1) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum. GO annotations related to this gene include poly(A) RNA binding and receptor activity. An important paralog of this gene is KTN1.

UniProtKB/Swiss-Prot for RRBP1 Gene

  • Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.

Gene Wiki entry for RRBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRBP1 Gene

Genomics for RRBP1 Gene

Regulatory Elements for RRBP1 Gene

Enhancers for RRBP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RRBP1 on UCSC Golden Path with GeneCards custom track

Promoters for RRBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RRBP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RRBP1 Gene

Chromosome:
20
Start:
17,613,678 bp from pter
End:
17,682,295 bp from pter
Size:
68,618 bases
Orientation:
Minus strand

Genomic View for RRBP1 Gene

Genes around RRBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRBP1 Gene

Proteins for RRBP1 Gene

  • Protein details for RRBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2E9-RRBP1_HUMAN
    Recommended name:
    Ribosome-binding protein 1
    Protein Accession:
    Q9P2E9
    Secondary Accessions:
    • A2A2S6
    • A6NCN6
    • O75300
    • O75301
    • Q5W165
    • Q96SB2
    • Q9BWP1
    • Q9H476

    Protein attributes for RRBP1 Gene

    Size:
    1410 amino acids
    Molecular mass:
    152472 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92636.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RRBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RRBP1 Gene

Proteomics data for RRBP1 Gene at MOPED

Post-translational modifications for RRBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RRBP1 Gene

Domains & Families for RRBP1 Gene

Protein Domains for RRBP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RRBP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RRBP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for RRBP1 Gene

Function for RRBP1 Gene

Molecular function for RRBP1 Gene

GENATLAS Biochemistry:
ribosome binding protein 1
UniProtKB/Swiss-Prot Function:
Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.

Gene Ontology (GO) - Molecular Function for RRBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9628588
genes like me logo Genes that share ontologies with RRBP1: view
genes like me logo Genes that share phenotypes with RRBP1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRBP1 Gene

Localization for RRBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRBP1 Gene

Endoplasmic reticulum membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RRBP1 Gene COMPARTMENTS Subcellular localization image for RRBP1 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for RRBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030176 integral component of endoplasmic reticulum membrane IEA,IBA --
genes like me logo Genes that share ontologies with RRBP1: view

Pathways & Interactions for RRBP1 Gene

genes like me logo Genes that share pathways with RRBP1: view

Pathways by source for RRBP1 Gene

1 KEGG pathway for RRBP1 Gene

Gene Ontology (GO) - Biological Process for RRBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
genes like me logo Genes that share ontologies with RRBP1: view

No data available for SIGNOR curated interactions for RRBP1 Gene

Drugs & Compounds for RRBP1 Gene

No Compound Related Data Available

Transcripts for RRBP1 Gene

Unigene Clusters for RRBP1 Gene

Ribosome binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RRBP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - -
SP2: - - -
SP3:
SP4: -
SP5:
SP6: -
SP7:
SP8: - - - - - - - -
SP9:
SP10: -
SP11:
SP12: -
SP13:

ExUns: 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28a · 28b · 28c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for RRBP1 Gene

GeneLoc Exon Structure for
RRBP1
ECgene alternative splicing isoforms for
RRBP1

Expression for RRBP1 Gene

mRNA expression in normal human tissues for RRBP1 Gene

mRNA differential expression in normal tissues according to GTEx for RRBP1 Gene

This gene is overexpressed in Pancreas (x6.3).

Protein differential expression in normal tissues from HIPED for RRBP1 Gene

This gene is overexpressed in Liver, secretome (21.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RRBP1 Gene



SOURCE GeneReport for Unigene cluster for RRBP1 Gene Hs.472213

genes like me logo Genes that share expression patterns with RRBP1: view

Protein tissue co-expression partners for RRBP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RRBP1 Gene

Orthologs for RRBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RRBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RRBP1 35
  • 99.15 (n)
  • 99.18 (a)
RRBP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RRBP1 36
  • 48 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RRBP1 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RRBP1 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rrbp1 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RRBP1 36
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves RRBP1 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RRBP1 36
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii -- 35
rrbp1a 36
  • 30 (a)
OneToMany
rrbp1b 36
  • 34 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13657 35
Species with no ortholog for RRBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RRBP1 Gene

ENSEMBL:
Gene Tree for RRBP1 (if available)
TreeFam:
Gene Tree for RRBP1 (if available)

Paralogs for RRBP1 Gene

Paralogs for RRBP1 Gene

(1) SIMAP similar genes for RRBP1 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for RRBP1 Gene

genes like me logo Genes that share paralogs with RRBP1: view

Variants for RRBP1 Gene

Sequence variations from dbSNP and Humsavar for RRBP1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1132274 - 17,615,510(-) ATGTC(A/G/T)GTTAC reference, missense
rs6599 -- 17,619,499(+) GCTTC(A/G)GGCAA intron-variant
rs8803 -- 17,614,156(-) AGTTA(C/T)TGTTC utr-variant-3-prime
rs9768 -- 17,619,377(+) TCAAA(C/T)GCCTC intron-variant
rs11960 -- 17,619,712(-) CACGT(C/T)GCATT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RRBP1 Gene

Variant ID Type Subtype PubMed ID
dgv4556n71 CNV Loss 21882294
nsv3311 CNV Insertion 18451855
nsv458943 CNV Loss 19166990
esv23450 CNV Gain 19812545
nsv519542 CNV Loss 19592680
dgv4557n71 CNV Loss 21882294
nsv527274 CNV Loss 19592680
nsv828695 CNV Gain 20364138
esv1521395 CNV Insertion 17803354
nsv180652 CNV Loss 16902084

Variation tolerance for RRBP1 Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.55; 97.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRBP1 Gene

HapMap Linkage Disequilibrium report
RRBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRBP1 Gene

Disorders for RRBP1 Gene

Relevant External Links for RRBP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RRBP1

No disorders were found for RRBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRBP1 Gene

Publications for RRBP1 Gene

  1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 67
  2. Identification, characterization, and chromosomal localization of the human homolog (hES) of ES/130. (PMID: 8812507) Basson C.T. … Seidman C.E. (Genomics 1996) 2 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for RRBP1 Gene

Sources for RRBP1 Gene

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