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RRBP1 Gene

protein-coding   GIFtS: 60
GCID: GC20M017594

Ribosome Binding Protein 1

(Previous names: ribosome binding protein 1 (dog 180kD homolog), ribosome...)
  See RRBP1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosome Binding Protein 11 2     ES1302 5
Ribosome Binding Protein 1 Homolog 180kDa (Dog)1 2     Ribosome Binding Protein 1 (Dog 180kD Homolog)1
Ribosome Receptor Protein2 3     ES/1302
180 KDa Ribosome Receptor Homolog2 3     hES2
RRp2 3     Ribosome-Binding Protein 12
ES/130-Related Protein2 3     KIAA13983

External Ids:    HGNC: 104481   Entrez Gene: 62382   Ensembl: ENSG000001258447   OMIM: 6014185   UniProtKB: Q9P2E93   

Export aliases for RRBP1 gene to outside databases

Previous GC identifers: GC20M017582 GC20M017589 GC20M017542 GC20M017557


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RRBP1 Gene:
This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this
gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of
ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by
regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in
variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ
in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7,
and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a
nearby gene on chromosome 20p12. (provided by RefSeq, Apr 2012)

GeneCards Summary for RRBP1 Gene:
RRBP1 (ribosome binding protein 1) is a protein-coding gene. Diseases associated with RRBP1 include anuria. GO annotations related to this gene include receptor activity. An important paralog of this gene is KTN1.

UniProtKB/Swiss-Prot: RRBP1_HUMAN, Q9P2E9
Function: Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum
membrane (By similarity)

Gene Wiki entry for RRBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011387.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the RRBP1 gene promoter:
         c-Fos   AhR   GR   AP-1   ATF-2   STAT3   c-Jun   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRRBP1 promoter sequence
   Search Chromatin IP Primers for RRBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RRBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p12   Ensembl cytogenetic band:  20p12.1   HGNC cytogenetic band: 20p12

RRBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RRBP1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M017594:  view genomic region     (about GC identifiers)

Start:
17,594,323 bp from pter      End:
17,662,940 bp from pter
Size:
68,618 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RRBP1_HUMAN, Q9P2E9 (See protein sequence)
Recommended Name: Ribosome-binding protein 1  
Size: 1410 amino acids; 152472 Da
Sequence caution: Sequence=BAA92636.2; Type=Erroneous initiation;
Secondary accessions: A2A2S6 A6NCN6 O75300 O75301 Q5W165 Q96SB2 Q9BWP1 Q9H476
Alternative splicing: 3 isoforms:  Q9P2E9-1   Q9P2E9-2   Q9P2E9-3   

Explore the universe of human proteins at neXtProt for RRBP1: NX_Q9P2E9

Explore proteomics data for RRBP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RRBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001036041.1  NP_004578.2  

    ENSEMBL proteins: 
     ENSP00000367044   ENSP00000354045   ENSP00000476483   ENSP00000381762   ENSP00000367038  
     ENSP00000246043   ENSP00000401206  

    RRBP1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for RRBP1

     
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    antibodies-online peptides for RRBP1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007794 Rib_rcpt_KP

    Graphical View of Domain Structure for InterPro Entry Q9P2E9

    ProtoNet protein and cluster: Q9P2E9


    Find genes that share domains with RRBP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RRBP1_HUMAN, Q9P2E9
    Function: Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum
    membrane (By similarity)

         Genatlas biochemistry entry for RRBP1:
    ribosome binding protein 1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS9628588
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with RRBP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RRBP1:
     Decreased circadian period len 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RRBP1

    miRNA
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    miRTarBase miRNAs that target RRBP1:
    hsa-let-7b-5p (MIRT052004), hsa-mir-34a-5p (MIRT025298), hsa-mir-1 (MIRT005285), hsa-mir-331-3p (MIRT043513), hsa-mir-335-5p (MIRT016910), hsa-mir-92a-3p (MIRT049448)

    Block miRNA regulation of human, mouse, rat RRBP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RRBP1 (see all 18):
    hsa-miR-3910 hsa-miR-25 hsa-miR-124 hsa-miR-4325 hsa-miR-3116 hsa-miR-506 hsa-miR-613 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidRRBP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RRBP1

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRBP1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRBP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RRBP1_HUMAN, Q9P2E9: Endoplasmic reticulum membrane; Single-pass type III membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005840ribosome TAS9628588
    GO:0030176integral component of endoplasmic reticulum membrane IEA--

    Find genes that share ontologies with RRBP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RRBP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum


    Find genes that share SuperPaths with RRBP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for RRBP1):
        Protein processing in endoplasmic reticulum

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RRBP1
    Interactions:

        Search GeneGlobe Interaction Network for RRBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for RRBP1 (Q9P2E92, 3 ENSP000003540454) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF7IPQ6VMQ62, 3MINT-61929 I2D: score=3 
    SMAD9O151982, 3MINT-62150 I2D: score=3 
    PRKD2Q9BZL62, 3MINT-61763 I2D: score=2 
    ZWINTO952293, ENSP000003630554I2D: score=2 STRING: ENSP00000363055
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS9628588
    GO:0007165signal transduction ----
    GO:0015031protein transport IEA--

    Find genes that share ontologies with RRBP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RRBP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RRBP1 gene (2 alternative transcripts): 
    NM_001042576.1  NM_004587.2  

    Unigene Cluster for RRBP1:

    Ribosome binding protein 1
    Hs.472213  [show with all ESTs]
    Unigene Representative Sequence: AB037819
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000468428(uc010zrp.1) ENST00000470422(uc002wpt.1) ENST00000377813(uc010zrq.1 uc010zrr.1)
    ENST00000360807(uc002wpw.1) ENST00000495501 ENST00000398782 ENST00000377807(uc002wpv.1 uc010gcl.1)
    ENST00000246043(uc002wpu.3) ENST00000455029(uc010gcm.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat RRBP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RRBP1 (see all 18):
    hsa-miR-3910 hsa-miR-25 hsa-miR-124 hsa-miR-4325 hsa-miR-3116 hsa-miR-506 hsa-miR-613 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidRRBP1 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRBP1
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    OriGene qSTAR qPCR primer pairs in human, mouse for RRBP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RRBP1
      QuantiTect SYBR Green Assays in human, mouse, rat RRBP1
      QuantiFast Probe-based Assays in human, mouse, rat RRBP1

    Additional mRNA sequence: 

    AB037819.2 AB287347.2 AF006751.1 AF007575.1 AK093465.1 AK098319.1 AK309197.1 AL833822.1 
    BC000099.2 BC009700.1 BC020482.1 BC080526.1 BC108741.1 BC128577.1 BC128578.1 

    Selected DOTS entries (see all 26):

    DT.95368057  DT.213446  DT.91669694  DT.100842247  DT.95368060  DT.75121014  DT.91742123  DT.99956110 
    DT.100842239  DT.100842236  DT.100044602  DT.120834813  DT.120834857  DT.100842233  DT.120834876  DT.100842240 
    DT.120834828  DT.120834878  DT.95368058  DT.100044605  DT.100842234  DT.91705773  DT.92448940  DT.95099927 

    Selected AceView cDNA sequences (see all 428):

    BP352965 BI712830 AL712146 CA447002 BU854882 AA745923 BQ223138 BQ931525 
    AW118981 AI074124 BQ685801 CD618970 BU180284 BM006419 BG326657 BQ002959 
    BF514727 BF508366 BQ070387 BI793160 BC000099 BQ424709 BU902078 AA158569 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RRBP1 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
    SP1:                                                                                                                          -                 -               
    SP2:                                                                    -                                                     -                 -               
    SP3:                                                                                                                                                            
    SP4:                                                                    -                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28a · 28b · 28c
    SP1:                    -                                                               
    SP2:                    -                                                               
    SP3:                    -                                                               
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for RRBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RRBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGACAAGT
    RRBP1 Expression
    About this image


    RRBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
    RRBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RRBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.472213
        Custom PCR Arrays for RRBP1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RRBP1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rrbp15 ribosome binding protein 1   --   2 (70.89 cM) 143947395 
    chicken
    (Gallus gallus)
    Aves RRBP16
    Gallus gallus ribosome binding protein 1 homolog 1...
    57(a)
    1 ↔ 1
    3(14871338-14889265)
    lizard
    (Anolis carolinensis)
    Reptilia RRBP16
    ribosome binding protein 1
    43(a)
    1 ↔ 1
    4(74337579-74374986)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC059298.12   -- 73.08(n)    BC059298.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC054580.12   -- 75.06(n)   368324  BC054580.1 


    ENSEMBL Gene Tree for RRBP1 (if available)
    TreeFam Gene Tree for RRBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RRBP1 gene
    KTN12  
    1 SIMAP similar gene for RRBP1 using alignment to 9 protein entries:     RRBP1_HUMAN (see all proteins):
    KTN1

    Find genes that share paralogs with RRBP1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for RRBP1
    PGOHUM00000259820 PGOHUM00000233229


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RRBP1 (see all 1889)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs777652711,2
    C,F--17593833(+) GGGTCG/ATGGCA 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1174700441,2
    F--17593849(+) AAGCTG/CGTTTC 2 -- ds50011Minor allele frequency- C:0.01NA 120
    rs1881123631,2
    --17593971(+) TTCCCA/GGACCT 2 -- ds50010--------
    rs1397984851,2
    C--17593978(+) ACCTC-/CATCACGC 2 -- ds50010--------
    rs2003930161,2
    --17593980(+) CTCCA-/TCACGC 2 -- ds50010--------
    rs18850821,2
    C,F,O,A,H--17593984(+) ATCACA/GCAACA 2 -- ds500133Minor allele frequency- N:0.00NS EA NA WA CSA 2880
    rs580784621,2
    C,F--17594006(+) CAGCCG/ACGCTC 2 -- ds50012Minor allele frequency- A:0.04WA 120
    rs60449081,2
    C,F,H--17594007(+) AGCCGC/TGCTCA 2 -- ds500113Minor allele frequency- T:0.14NS EA NA WA CSA 553
    rs61361491,2
    C,F,A,H--17594030(+) CCTCCA/GGGATG 2 -- ds500116Minor allele frequency- G:0.44NS EA NA WA CSA 743
    rs758765871,2
    F--17594036(+) GGATGC/TGGGGC 2 -- ds50011Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for RRBP1 (17594323 - 17662940 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for RRBP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1521395CNV Insertion17803354
    nsv3311CNV Insertion18451855
    dgv4556n71CNV Loss21882294
    dgv4557n71CNV Loss21882294
    nsv458943CNV Loss19166990
    nsv180652CNV Loss16902084
    nsv519542CNV Loss19592680
    nsv527274CNV Loss19592680
    nsv828695CNV Gain20364138
    esv23450CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601418    OMIM disorders: --

    1 disease for RRBP1:    
    About MalaCards
    anuria

    2 diseases from the University of Copenhagen DISEASES database for RRBP1:
    Anuria     Kidney failure

    Find genes that share disorders with RRBP1           About GenesLikeMe


    Export disorders for RRBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RRBP1 gene, integrated from 10 sources (see all 69):
    (articles sorted by number of sources associating them with RRBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    6. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    7. Identification of multiple forms of 180-kDa ribosome receptor in human cells. (PubMed id 9628588)1, 2 Langley R.... Krissansen G.W. (DNA Cell Biol. 1998)
    8. Identification, characterization, and chromosomal localization of the human homolog (hES) of ES/130. (PubMed id 8812507)1, 3 Basson C.T....Seidman C.E. (Genomics 1996)
    9. Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP. (PubMed id 22963397)1 Wang B.S....Wang M.R. (Clin. Sci. 2013)
    10. Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78. (PubMed id 23318453)1 Tsai H.Y....Hsiao M. (Oncogene 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6238 HGNC: 10448 AceView: RRBP1 Ensembl:ENSG00000125844 euGenes: HUgn6238
    ECgene: RRBP1 Kegg: 6238 H-InvDB: RRBP1

    (According to HUGE)
    About This Section

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    HUGE: KIAA1398

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RRBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RRBP1 gene:
    Search GeneIP for patents involving RRBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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