Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RRAS2 Gene

protein-coding   GIFtS: 69
GCID: GC11M014299

Related RAS Viral (R-Ras) Oncogene Homolog 2

  See RRAS2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Related RAS Viral (R-Ras) Oncogene Homolog 21 2
TC212 3 5
Ras-Like Protein TC212 3
Teratocarcinoma Oncogene2 3
Ras-Related Protein R-Ras22

External Ids:    HGNC: 172711   Entrez Gene: 228002   Ensembl: ENSG000001338187   OMIM: 6000985   UniProtKB: P620703   

Export aliases for RRAS2 gene to outside databases

Previous GC identifers: GC11M015479 GC11M015047 GC11M014339 GC11M014264 GC11M014256 GC11M013981


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RRAS2 Gene:
This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with
the plasma membrane and may function as a signal transducer. This protein may play an important role in
activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated
with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing
results in multiple transcript variants. (provided by RefSeq, Apr 2010)

GeneCards Summary for RRAS2 Gene:
RRAS2 (related RAS viral (r-ras) oncogene homolog 2) is a protein-coding gene. Diseases associated with RRAS2 include ovarian cancer, and teratocarcinoma. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is REM1.

UniProtKB/Swiss-Prot: RRAS2_HUMAN, P62070
Function: It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth
inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins
but in an antagonistic fashion

Gene Wiki entry for RRAS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the RRAS2 gene promoter:
         PPAR-gamma1   p300   PPAR-gamma2   NF-kappaB   NF-kappaB1   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for RRAS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RRAS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.2   Ensembl cytogenetic band:  11p15.2   HGNC cytogenetic band: 11p15.2

RRAS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RRAS2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M014299:  view genomic region     (about GC identifiers)

Start:
14,299,466 bp from pter      End:
14,386,052 bp from pter
Size:
86,587 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RRAS2_HUMAN, P62070 (See protein sequence)
Recommended Name: Ras-related protein R-Ras2 precursor  
Size: 204 amino acids; 23400 Da
Sequence caution: Sequence=AAA36545.1; Type=Frameshift; Positions=4, 8, 12; Sequence=AAM12638.1; Type=Frameshift;
Positions=4, 8, 12;
1 PDB 3D structure from and Proteopedia for RRAS2:
2ERY (3D)    
Secondary accessions: B2R9Z3 B7Z6C4 B7Z7H6 P17082
Alternative splicing: 3 isoforms:  P62070-1   P62070-2   P62070-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RRAS2: NX_P62070

Explore proteomics data for RRAS2 at MOPED

Post-translational modifications: 

  • May be post-translationally modified by both palmitoylation and polyisoprenylation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RRAS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001096139.1  NP_001170785.1  NP_001170786.1  NP_036382.2  

    ENSEMBL proteins: 
     ENSP00000403282   ENSP00000433230   ENSP00000256196   ENSP00000437083   ENSP00000434104  
     ENSP00000431954   ENSP00000435453   ENSP00000436190   ENSP00000432559   ENSP00000436887  
     ENSP00000437547   ENSP00000441722  

    RRAS2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RRAS2
    OriGene Protein Over-expression Lysate for RRAS2
    OriGene MassSpec for RRAS2
    OriGene Custom Protein Services for RRAS2
    GenScript Custom Purified and Recombinant Proteins Services for RRAS2
    Novus Biologicals RRAS2 Proteins
    Novus Biologicals RRAS2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for RRAS2
    Cloud-Clone Corp. Proteins for RRAS2

     
    Search eBioscience for Proteins for RRAS2 

     
    antibodies-online proteins for RRAS2 (14 products) 

     
    antibodies-online peptides for RRAS2

    RRAS2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for RRAS2 (TC21/R-Ras2)
    OriGene Antibodies for RRAS2
    OriGene Custom Antibody Services for RRAS2
    Novus Biologicals RRAS2 Antibodies
    Abcam antibodies for RRAS2
    Cloud-Clone Corp. Antibodies for RRAS2
    ThermoFisher Antibody for RRAS2
    antibodies-online antibodies for RRAS2 (37 products) 

    RRAS2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RRAS2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RRAS2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RRAS2
    Cloud-Clone Corp. CLIAs for RRAS2
    Search eBioscience for ELISAs for RRAS2 
    antibodies-online kits for RRAS2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry P62070

    ProtoNet protein and cluster: P62070

    3 Blocks protein domains:
    IPB002041 GTP-binding nuclear protein Ran
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RRAS2_HUMAN, P62070
    Similarity: Belongs to the small GTPase superfamily. Ras family


    Find genes that share domains with RRAS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RRAS2_HUMAN, P62070
    Function: It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth
    inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins
    but in an antagonistic fashion

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS10777492
    GO:0005515protein binding IPI12620389
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with RRAS2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RRAS2:
     Increased cell death in breast  Increased cell number in G2M,  

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rras2):
     adipose tissue  cardiovascular system  growth/size/body  hematopoietic system  immune system 
     other  tumorigenesis  vision/eye 

    Find genes that share phenotypes with RRAS2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rras2tm1Itl for RRAS2

       genOway: Develop your customized and physiologically relevant rodent model for RRAS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target RRAS2:
    hsa-mir-93-5p (MIRT028141), hsa-mir-19b-3p (MIRT031260), hsa-mir-124-3p (MIRT022861), hsa-mir-26b-5p (MIRT029816), hsa-mir-7-5p (MIRT025875)

    Block miRNA regulation of human, mouse, rat RRAS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RRAS2 (see all 24):
    hsa-miR-549 hsa-miR-300 hsa-miR-520d-5p hsa-miR-188-5p hsa-miR-548l hsa-miR-223 hsa-miR-3161 hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidRRAS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RRAS2
    Predesigned siRNA for gene silencing in human, mouse, rat RRAS2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RRAS2

    Clone
    Products:
         
    OriGene clones in human, mouse for RRAS2 (see all 22)
    OriGene ORF clones in mouse, rat for RRAS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): RRAS2 (NM_012250)
    Sino Biological Human cDNA Clone for RRAS2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RRAS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRAS2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RRAS2
    Browse ESI BIO Cell Lines and PureStem Progenitors for RRAS2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRAS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RRAS2_HUMAN, P62070: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Inner surface of plasma
    membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum4
    cytosol3
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005783endoplasmic reticulum NAS10777492
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with RRAS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RRAS2 About   (see all 45)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    2ErbB4 Pathway
    ErbB4 Pathway0.59
    UVC-Induced MAPK Signaling0.44
    ErbB Family Pathway0.59
    TREM1 Pathway0.43
    Prolactin Signaling0.54
    FGF Pathway0.37
    Thrombopoietin Pathway0.51
    HMGB1 Pathway0.36
    3Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    ERK5 Signaling0.61
    Rac1 Pathway0.65
    eIF2 Pathway0.60
    Glioma Invasiveness0.64
    Rap1 Pathway0.57
    4GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    Estrogen Pathway0.55
    GPCR Pathway0.62
    P2Y Receptor Signaling0.38
    5fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    Internalin Pathway0.31


    Find genes that share SuperPaths with RRAS2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RRAS2 (see all 108)
        Fc-GammaR Pathway
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    CDK5 Pathway

    2 GeneGo (Thomson Reuters) Pathways for RRAS2
        G-protein signaling TC21 regulation pathway
    G-protein signaling G-Protein alpha-12 signaling pathway

    1 BioSystems Pathway for RRAS2
        Regulation of Actin Cytoskeleton



    Selected Kegg Pathways  (Kegg details for RRAS2) (see all 6):
        MAPK signaling pathway
    Ras signaling pathway
    Tight junction
    Regulation of actin cytoskeleton
    HTLV-I infection

        Pathway & Disease-focused RT2 Profiler PCR Array including RRAS2: 
              Insulin Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RRAS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RRAS2 (P620701, 2, 3 ENSP000002561964) via UniProtKB, MINT, STRING, and/or I2D (see all 207)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LGALS4P564702, 3MINT-63952 I2D: score=5 
    XRCC6P129562, 3MINT-63953 I2D: score=5 
    ENSG00000206282O152113I2D: score=1 
    ENSG00000224841O152113I2D: score=1 
    ENSG00000228736O152113I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction ----

    Find genes that share ontologies with RRAS2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RRAS2

    1 HMDB Compound for RRAS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    7 Novoseek inferred chemical compound relationships for RRAS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 58.5 4 19692568 (1), 15774489 (1)
    tetrapeptide 52.3 1 11401436 (1)
    gtp 46.9 6 8637701 (2), 19692568 (1), 15774489 (1)
    agar 31.8 1 17656362 (1)
    threonine 22.1 1 10064593 (1)
    serine 6.71 1 10064593 (1)
    tyrosine 0 1 10203263 (1)



    Find genes that share compounds with RRAS2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RRAS2 gene (4 alternative transcripts): 
    NM_001102669.2  NM_001177314.1  NM_001177315.1  NM_012250.5  

    Unigene Cluster for RRAS2:

    Related RAS viral (r-ras) oncogene homolog 2
    Hs.502004  [show with all ESTs]
    Unigene Representative Sequence: NM_012250
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000414023 ENST00000529237 ENST00000256196 ENST00000534746 ENST00000526063
    ENST00000532814 ENST00000531807 ENST00000532950 ENST00000531421 ENST00000526717
    ENST00000537760(uc021qec.1 uc009ygq.3 uc021qed.1) ENST00000545643(uc010rco.2 uc001mlf.4)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RRAS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RRAS2 (see all 24):
    hsa-miR-549 hsa-miR-300 hsa-miR-520d-5p hsa-miR-188-5p hsa-miR-548l hsa-miR-223 hsa-miR-3161 hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidRRAS2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RRAS2
    Predesigned siRNA for gene silencing in human, mouse, rat RRAS2
    Clone
    Products:
         
    OriGene clones in human, mouse for RRAS2 (see all 22)
    OriGene ORF clones in mouse, rat for RRAS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): RRAS2 (NM_012250)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RRAS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRAS2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RRAS2
    OriGene qSTAR qPCR primer pairs in human, mouse for RRAS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RRAS2
      QuantiTect SYBR Green Assays in human, mouse, rat RRAS2
      QuantiFast Probe-based Assays in human, mouse, rat RRAS2

    Additional mRNA sequence: 

    AF493924.1 AK299606.1 AK300103.1 AK302033.1 AK309550.1 AK309683.1 AK313976.1 BC013106.1 
    M31468.1 

    10 DOTS entries:

    DT.95161360  DT.100810812  DT.97796085  DT.120694456  DT.120694474  DT.102844245  DT.120694490  DT.95150956 
    DT.100818146  DT.95283252 

    Selected AceView cDNA sequences (see all 190):

    AI762862 BQ023701 AA765542 AA481252 W37783 BQ029973 T97190 AA315480 
    AA811274 CA421530 BQ020351 BX118478 CA423401 AI128139 AA723085 CF242914 
    CR592913 AI683305 AA011458 AA011401 BM701373 AA885762 NM_012250 H44434 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RRAS2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
    SP1:              -     -                           
    SP2:                    -                           
    SP3:              -                                 


    ECgene alternative splicing isoforms for RRAS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RRAS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTTTATAG
    RRAS2 Expression
    About this image


    RRAS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Zeugopod Growth Plate
    RRAS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RRAS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.502004

    UniProtKB/Swiss-Prot: RRAS2_HUMAN, P62070
    Tissue specificity: Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and
    skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Array including RRAS2: 
              Insulin Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RRAS2
    OriGene qSTAR qPCR primer pairs in human, mouse for RRAS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RRAS2
    QuantiTect SYBR Green Assays in human, mouse, rat RRAS2
    QuantiFast Probe-based Assays in human, mouse, rat RRAS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRAS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RRAS2 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rras21 , 5 related RAS viral (r-ras) oncogene homolog 21, 5 92.97(n)1
    100(a)1
      7 (59.29 cM)5
    669221  NM_025846.21  NP_080122.21 
     1140467855 
    chicken
    (Gallus gallus)
    Aves RRAS21 related RAS viral (r-ras) oncogene homolog 2 86.14(n)
    97.52(a)
      423062  NM_001006466.1  NP_001006466.1 
    lizard
    (Anolis carolinensis)
    Reptilia RRAS26
    related RAS viral (r-ras) oncogene homolog 2
    96(a)
    1 ↔ 1
    GL343294.1(537591-581808)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.116402 Xenopus laevis transcribed sequence with moderate similarity more 76.77(n)    48012437 
    zebrafish
    (Danio rerio)
    Actinopterygii rras21 related RAS viral (r-ras) oncogene homolog 2 79.77(n)
    96.02(a)
      550513  NM_001017815.1  NP_001017815.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ras64B1 , 3 RAS small monomeric GTPase3
    Ras oncogene at 64B1
    71(a)3
    62.92(n)1
    71.12(a)1
      64A83
    384941  NM_079193.41  NP_523917.21 
    worm
    (Caenorhabditis elegans)
    Secernentea ras-11 , 3 ras-11 62(a)
    (best of 3)3
    61.08(n)1
    63.01(a)1
      II(12345165-12347292)3
    1748751  NM_064222.61  NP_496623.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RAS1(YOR101W)4
    RAS11
    GTPase involved in G-protein signaling in the adenylate more4
    RAS11
    63.56(n)1
    64.67(a)1
      15(515244-516173)4
    8542681, 4  NP_014744.11, 4 


    ENSEMBL Gene Tree for RRAS2 (if available)
    TreeFam Gene Tree for RRAS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RRAS2 gene
    REM12  RALA2  RRAS2  RALB2  ERAS2  RRAD2  NRAS2  REM22  
    KRAS2  GEM2  HRAS2  MRAS2  
    Selected SIMAP similar genes for RRAS2 using alignment to 6 protein entries:     RRAS2_HUMAN (see all proteins) (see all similar genes):
    N-ras    K-RAS    K-ras    c-bas/has    RRAS    MRAS
    KRAS    HRAS    RERG    RAP1B    RALB    DKFZp547A0616
    RAP2B    RALA    RAP2A    RAP1A    NRAS    DKFZp686J06205

    Find genes that share paralogs with RRAS2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for RRAS2
    PGOHUM00000234921 PGOHUM00000240534


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RRAS2 (see all 1371)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0068484
    An ovarian cancer sample4--see VAR_0068482 Q L mis40--------
    rs1139549971,2
    Cother114239871(-) AGGACA/C/TAGAAG 6 Q L mis1 ut511CSA 2
    rs1437013401,2
    --14222484(+) TGTGCA/GCCACT 4 -- ds50010--------
    rs749649731,2
    C,F--14222535(+) AATGTG/ATGTGT 4 -- ds50011Minor allele frequency- A:0.04NA 120
    rs1384383171,2
    --14222685(+) AAAGAA/TCATCA 4 -- ds50010--------
    rs1140018051,2
    F--14222714(+) CCACCT/GGCTGA 4 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1429796371,2
    --14222996(+) TACTAC/TTGAAT 4 -- ut310--------
    rs558720411,2
    C--14223021(+) CCACAA/GAATTA 4 -- ut310--------
    rs1858224961,2
    --14223107(+) TCAATA/GTCTAG 4 -- ut310--------
    rs1905306691,2
    --14223114(+) CTAGCA/CGGGAA 4 -- ut310--------

    HapMap Linkage Disequilibrium report for RRAS2 (14299466 - 14386052 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for RRAS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744128CNV Deletion23290073
    esv1753534CNV Deletion17803354
    esv990812CNV Deletion20482838
    esv4848CNV Deletion18987735
    esv990130CNV Insertion20482838
    nsv38548CNV Loss16902084
    esv6194CNV Loss19470904
    esv25684CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RRAS2
    DNA2.0 Custom Variant and Variant Library Synthesis for RRAS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600098    OMIM disorders: --

    UniProtKB/Swiss-Prot: RRAS2_HUMAN, P62070
  • Ovarian cancer (OC) [MIM:167000]: The term ovarian cancer defines malignancies originating from ovarian
    tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the
    most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of
    late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry

  • 3 diseases for RRAS2:    
    About MalaCards
    ovarian cancer    teratocarcinoma    acute urate nephropathy


    Find genes that share disorders with RRAS2           About GenesLikeMe

    2 Novoseek inferred disease relationships for RRAS2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 23.4 15 19047159 (2), 7478545 (2), 8552388 (1), 11340168 (1) (see all 6)
    breast cancer 14.6 2 19047159 (2)

    Genetic Association Database (GAD): RRAS2
    Human Genome Epidemiology (HuGE) Navigator: RRAS2 (3 documents)

    Export disorders for RRAS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RRAS2 gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with RRAS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human oncogene of the RAS superfamily unmasked by expression cDNA cloning. (PubMed id 8052619)1, 2, 3 Chan A.M.-L.... Aaronson S.A. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    2. Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line. (PubMed id 2108320)1, 2, 3 Drivas G.T.... D'Eustachio P. (Mol. Cell. Biol. 1990)
    3. A polymorphism in the TC21 promoter associates with an unfavorable tamoxifen treatment outcome in breast cancer. (PubMed id 19047159)1, 4, 9 Rokavec M....Brauch H. (Cancer Res. 2008)
    4. Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease. (PubMed id 18628988)1, 4 Li Y....Hadjigeorgiou G. (PLoS ONE 2008)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. (PubMed id 15308774)1, 2 Kho Y.... Zhao Y. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Structural and spatial determinants regulating TC21 activation by RasGRF family nucleotide exchange factors. (PubMed id 19692568)1, 9 Calvo F. and Crespo P. (Mol. Biol. Cell 2009)
    9. Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells. (PubMed id 10064593)1, 9 RosA!rio M....Marshall C.J. (EMBO J. 1999)
    10. Signaling pathways regulating TC21-induced tumorigenesis. (PubMed id 17656362)1, 9 Erdogan M....Zent R. (J. Biol. Chem. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 22800 HGNC: 17271 AceView: RRAS2 Ensembl:ENSG00000133818 euGenes: HUgn22800
    ECgene: RRAS2 Kegg: 22800 H-InvDB: RRAS2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RRAS2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RRAS2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RRAS2 gene:
    Search GeneIP for patents involving RRAS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for RRAS2 (TC21/R-Ras2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RRAS2   OriGene RNAi products in human, mouse, rat for RRAS2  
     OriGene qPCR primer pairs and template standards for RRAS2   OriGene Protein Over-expression Lysate for RRAS2  
     OriGene MassSpec for RRAS2   OriGene clones in human, mouse for RRAS2  
     OriGene qSTAR qPCR primer pairs in human, mouse for RRAS2   OriGene Purified Protein for RRAS2  
     OriGene ORF clones in mouse, rat for RRAS2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RRAS2   OriGene Custom Protein Services for RRAS2  

     
     
     Block miRNA regulation of human, mouse, rat RRAS2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RRAS2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RRAS2 Predesigned siRNA for gene silencing in human, mouse, rat RRAS2
     QuantiFast Probe-based Assays in human, mouse, rat RRAS2 QuantiTect SYBR Green Assays in human, mouse, rat RRAS2
     PCR Arrays including human, mouse, rat RRAS2 Search Chromatin IP Primers for RRAS2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RRAS2  GeneGlobe Interaction Network for RRAS2
     Regulatory tfbs in RRAS2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RRAS2 GenScript cDNA clones with any tag delivered in your preferred vector for RRAS2
     GenScript Custom Assay Services for RRAS2 GenScript Custom overexpressing Cell Line Services for RRAS2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RRAS2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for RRAS2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RRAS2 antibodies
     RRAS2 proteins
     RRAS2 lysates
     Antibodies for RRAS2
     See all of Abcam's Antibodies, Kits and Proteins for RRAS2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for RRAS2
     Proteins for RRAS2
     Antibodies for RRAS2
     ELISAs for RRAS2
     CLIAs for RRAS2



     Browse ESI BIO Cell Lines and PureStem Progenitors for RRAS2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRAS2
     SwitchGear 3'UTR luciferase reporter plasmids for RRAS2
     Browse SwitchGear Promoter luciferase reporter plasmids for RRAS2
     ThermoFisher Antibody for RRAS2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRAS2
     Browse compounds at ApexBio
     Search Addgene for plasmids for RRAS2
      Search eBioscience for proteins for RRAS2
      Search eBioscience for elisas for RRAS2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for RRAS2
     antibodies-online antibodies for RRAS2 (37 products)
     antibodies-online kits for RRAS2 (4 products)
     antibodies-online peptides for RRAS2
     antibodies-online proteins for RRAS2 (14 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RRAS2 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4