Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RRAS2 Gene

protein-coding GIFtS: 66
GCID: GC11M014299

related RAS viral (r-ras) oncogene homolog 2

Explore 12 diseases affiliated with
RRAS2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Related RAS Viral (R-Ras) Oncogene Homolog 2¹ ²
TC21¹ ² ³ ⁵
Ras-Like Protein TC21² ³
Teratocarcinoma Oncogene² ³
Ras-Related Protein R-Ras2²

External Ids:	HGNC: 17271¹	Entrez Gene: 22800²	Ensembl: ENSG00000133818⁷	OMIM: 600098⁵	UniProtKB: P62070³

Export aliases for RRAS2 gene to outside databases

Previous GC identifers: GC11M015479 GC11M015047 GC11M014339 GC11M014264 GC11M014256 GC11M013981

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RRAS2:

This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the

plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal

transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of

certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple

transcript variants. (provided by RefSeq, Apr 2010)

UniProtKB/Swiss-Prot: RRAS2_HUMAN, P62070

Function: It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth

inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but

in an antagonistic fashion

Gene Wiki entry for RRAS2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RRAS2 gene promoter:
PPAR-gamma1 p300 PPAR-gamma2 NF-kappaB NF-kappaB1 RSRFC4
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for RRAS2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RRAS2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.2 Ensembl cytogenetic band: 11p15.2 HGNC cytogenetic band: 11p15.2

RRAS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RRAS2 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M014299: view genomic region (about GC identifiers)

Start:	14,299,466 bp from pter	End:	14,386,052 bp from pter
Size:	86,587 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RRAS2_HUMAN, P62070 (See protein sequence)

Recommended Name: Ras-related protein R-Ras2 precursor

Size: 204 amino acids; 23400 Da

Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Inner surface of plasma

membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS)

Sequence caution: Sequence=AAA36545.1; Type=Frameshift; Positions=4, 8, 12; Sequence=AAM12638.1; Type=Frameshift;

Positions=4, 8, 12;

1 PDB 3D structure from and Proteopedia for RRAS2:

2ERY (3D)

Secondary accessions: B2R9Z3 B7Z6C4 B7Z7H6 P17082

Alternative splicing: 3 isoforms: P62070-1 P62070-2 P62070-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RRAS2: NX_P62070

Post-translational modifications:

May be post-translationally modified by both palmitoylation and polyisoprenylation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P62070

RRAS2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001096139.1 NP_001170785.1 NP_001170786.1 NP_036382.2

ENSEMBL proteins:

ENSP00000403282 ENSP00000433230 ENSP00000256196 ENSP00000437083 ENSP00000434104

ENSP00000431954 ENSP00000435453 ENSP00000436190 ENSP00000432559 ENSP00000436887

ENSP00000437547 ENSP00000441722

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: RRAS2 OriGene Protein Over-expression Lysate: RRAS2 OriGene Custom Protein Services for RRAS2
	GenScript Custom Purified and Recombinant Proteins Services for RRAS2
	Novus Biologicals RRAS2 Proteins Novus Biologicals RRAS2 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for RRAS2
	Uscn Proteins for RRAS2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005783	endoplasmic reticulum	NAS	10777492
GO:0005886	plasma membrane	IEA	--
GO:0016020	membrane	--	--

RRAS2 for ontologies About GeneDecksing

RRAS2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for RRAS2 (TC21/R-Ras2)
	OriGene Antibodies: RRAS2 OriGene Custom Antibody Services for RRAS2
	GenScript Custom Superior Antibodies Services for RRAS2
	Novus Biologicals RRAS2 Antibodies
	Search for Antibodies for RRAS2 at Abcam
	Uscn Antibodies for RRAS2
	ThermoFisher Antibody for RRAS2

Assay Products for RRAS2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RRAS2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RRAS2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RRAS2 for domains About GeneDecksing

3 InterPro domains/families:

IPR005225 Small_GTP-bd_dom

IPR001806 Small_GTPase

IPR020849 Small_GTPase_Ras

Graphical View of Domain Structure for InterPro Entry P62070

ProtoNet protein and cluster: P62070

3 Blocks protein families:

IPB002041 GTP-binding nuclear protein Ran

IPB003577 Ras small GTPase

IPB003578 Ras small GTPase

UniProtKB/Swiss-Prot: RRAS2_HUMAN, P62070

Similarity: Belongs to the small GTPase superfamily. Ras family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RRAS2_HUMAN, P62070

Function: It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth

inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but

in an antagonistic fashion

miRNA Products:		OriGene 3'-UTR Clone (see all 2): RRAS2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RRAS2
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate RRAS2 (see all 24):
		hsa-miR-549 hsa-miR-300 hsa-miR-520d-5p hsa-miR-188-5p hsa-miR-548l hsa-miR-223 hsa-miR-3161 hsa-miR-23a

		SwitchGear 3'UTR luciferase reporter plasmid: RRAS2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RRAS2 (see all 7) OriGene shRNA RFP: RRAS2 OriGene siRNA: RRAS2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RRAS2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RRAS2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RRAS2 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RRAS2 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): RRAS2 (NM_012250)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RRAS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRAS2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RRAS2
		Search LifeMap BioReagents cell lines for RRAS2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRAS2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	IEA	--
GO:0005515	protein binding	IPI	12620389
GO:0005525	GTP binding	IEA	--

RRAS2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for RRAS2:

Increased cell death in breast

Increased cell number in G2M,

Animal Models:
Mouse knock-out Rras2^tm1Itl for RRAS2
9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Rras2):

adipose tissue	cardiovascular system	cellular	growth/size	hematopoietic system
immune system	other	tumorigenesis	vision/eye

RRAS2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/44 super-pathways (see all 44) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

ErbB4 Pathway

8/11 pathways (see all 11)
ErbB4 Pathway	1.00	Thrombopoietin Pathway	0.43
ErbB Family Pathway	0.59	LPS Stimulated MAPK Signaling	0.36
Prolactin Signaling	0.54	TREM1 Pathway	0.32
ErbB2-ErbB3 Heterodimers	0.47	HMGB1 Pathway	0.32

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Paxillin Interactions	0.53
Breast Cancer Regulation by Stathmin1	0.58	P2Y Receptor Signaling	0.38

CCR3 Pathway in Eosinophils

CCR3 Pathway in Eosinophils	1.00	CXCR4 Pathway	0.39
VEGF and S-1P Signaling	0.44	Alpha-Adrenergic Signaling	0.31
fMLP Pathway	0.43	Internalin Pathway	0.19

Apoptotic Pathways in Synovial Fibroblasts

PPAR Pathway	0.66	Rac1 Pathway	0.58
ERK5 Signaling	0.61	Glioma Invasiveness	0.54
eIF2 Pathway	0.60	Rap1 Pathway	0.42

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for RRAS2

	G-protein signaling TC21 regulation pathway
	G-protein signaling G-Protein alpha-12 signaling pathway

5/108 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RRAS2 (see all 108)

	Fc-GammaR Pathway
	Molecular Mechanisms of Cancer
	eIF2 Pathway
	Intracellular Calcium Signaling
	CDK5 Pathway

2 GeneGo (Thomson Reuters) Pathways for RRAS2

	G-protein signaling TC21 regulation pathway
	G-protein signaling G-Protein alpha-12 signaling pathway

1 BioSystems Pathway for RRAS2

Regulation of Actin Cytoskeleton

3 Kegg Pathways (Kegg details for RRAS2):

	MAPK signaling pathway
	Tight junction
	Regulation of actin cytoskeleton

RRAS2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RRAS2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/57 Interacting proteins for RRAS2 (P62070^{1, 2, 3} ENSP00000256196⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 57)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LGALS4	P56470²^,³	MINT-63952 I2D: score=5
XRCC6	P12956²^,³	MINT-63953 I2D: score=5
ARAF	P10398¹^,³, ENSP00000366244⁴	EBI-491037,EBI-365961 I2D: score=3 STRING: ENSP00000366244
PAWR	Q96IZ0²^,³, ENSP00000328088⁴	MINT-63954 I2D: score=4 STRING: ENSP00000328088
ACVR1	Q04771³, ENSP00000263640⁴	I2D: score=3 STRING: ENSP00000263640

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006184	GTP catabolic process	--	--
GO:0007264	small GTPase mediated signal transduction	--	--
GO:0007265	Ras protein signal transduction	IEA	--
GO:0009987	cellular process	--	--
GO:0030335	positive regulation of cell migration	IEA	--

RRAS2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RRAS2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RRAS2

1 HMDB Compound for RRAS2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

7 Novoseek chemical compound relationships for RRAS2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gdp	58.5	4	19692568 (1), 15774489 (1)
tetrapeptide	52.3	1	11401436 (1)
gtp	46.9	6	8637701 (2), 19692568 (1), 15774489 (1)
agar	31.8	1	17656362 (1)
threonine	22.1	1	10064593 (1)
serine	6.71	1	10064593 (1)
tyrosine	0	1	10203263 (1)

Search CenterWatch for drugs/clinical trials and news about RRAS2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RRAS2 gene (4 alternative transcripts):

NM_001102669.2 NM_001177314.1 NM_001177315.1 NM_012250.5

Unigene Cluster for RRAS2:

Related RAS viral (r-ras) oncogene homolog 2

Hs.502004 [show with all ESTs]

Unigene Representative Sequence: NM_012250

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000414023 ENST00000529237 ENST00000256196 ENST00000534746 ENST00000526063

ENST00000532814 ENST00000531807 ENST00000532950 ENST00000531421 ENST00000526717

ENST00000537760(uc021qec.1 uc009ygq.3 uc021qed.1) ENST00000545643(uc010rco.2 uc001mlf.4)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): RRAS2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RRAS2
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate RRAS2 (see all 24):
		hsa-miR-549 hsa-miR-300 hsa-miR-520d-5p hsa-miR-188-5p hsa-miR-548l hsa-miR-223 hsa-miR-3161 hsa-miR-23a

		SwitchGear 3'UTR luciferase reporter plasmid: RRAS2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RRAS2 (see all 7) OriGene shRNA RFP: RRAS2 OriGene siRNA: RRAS2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RRAS2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RRAS2 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RRAS2 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): RRAS2 (NM_012250)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RRAS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRAS2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RRAS2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RRAS2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RRAS2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RRAS2

Additional cDNA sequence:

AF493924.1 AK299606.1 AK300103.1 AK302033.1 AK309550.1 AK309683.1 AK313976.1 BC013106.1

M31468.1

10 DOTS entries:

DT.95161360 DT.100810812 DT.97796085 DT.120694456 DT.120694474 DT.102844245 DT.120694490 DT.95150956

DT.100818146 DT.95283252

24/190 AceView cDNA sequences (see all 190):

AA011458 BU608451 AA935054 T97190 NM_012250 CA423401 CR592913 AA885762

AW949870 BI091803 BQ029973 BX118478 BQ020351 BE887570 AI128139 AA723085

CF242914 AI683305 BM701373 H44434 AA765542 W37783 AA481252 AI494098

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for RRAS2 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7
SP1:					-		-
SP2:							-
SP3:					-

ECgene alternative splicing isoforms for RRAS2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RRAS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGTTTATAG

About this image

RRAS2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RRAS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RRAS2

SOURCE GeneReport for Unigene cluster: Hs.502004

UniProtKB/Swiss-Prot: RRAS2_HUMAN, P62070

Tissue specificity: Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and

skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas

SABiosciences Expression via Pathway-Focused PCR Array including RRAS2:

Insulin Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RRAS2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RRAS2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RRAS2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RRAS2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRAS2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for RRAS2 gene from 7/28 species (see all 28) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RRAS2¹	related RAS viral (r-ras) oncogene homolog 2	86.14(n) 97.52(a)		423062 NM_001006466.1 NP_001006466.1
lizard (Anolis carolinensis)	Reptilia	RRAS2⁶	--	94(a)	1 ↔ 1	GL343294.1(575081-581760)
African clawed frog (Xenopus laevis)	Amphibia	Xl.11640²	Xenopus laevis transcribed sequence with moderate similarity more	76.77(n)		48012437
zebrafish (Danio rerio)	Actinopterygii	rras2¹	related RAS viral (r-ras) oncogene homolog 2	79.77(n) 96.02(a)		550513 NM_001017815.1 NP_001017815.1
fruit fly (Drosophila melanogaster)	Insecta	Ras64B^{1 , 3}	RAS small monomeric GTPase³ Ras oncogene at 64B¹	71(a)³ 62.92(n)¹ 71.12(a)¹		64A8³ 38494¹ NM_079193.3¹ NP_523917.2¹
worm (Caenorhabditis elegans)	Secernentea	ras-1^{1 , 3}	Protein RAS-1¹	62(a) (best of 3)³ 61.78(n)¹ 64.67(a)¹		II(12345165-12347292)³ 174875¹ NM_064222.5¹ NP_496623.1¹
A. gossypii yeast (Ashbya gossypii)	Saccharomycetes	AGOS_ADL262W¹	ADL262Wp	58.69(n) 63.8(a)		4619969 NM_209187.1 NP_983834.1

ENSEMBL Gene Tree for RRAS2 (if available)
TreeFam Gene Tree for RRAS2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RRAS2 gene

REM1² RALA² RIT2² RIT1² RRAS² ERAS² RALB² NRAS²

RRAD² REM2² KRAS² GEM² HRAS² MRAS²

18/95 SIMAP similar genes for RRAS2 using alignment to 6 protein entries: RRAS2_HUMAN (see all proteins) (see all similar genes):

N-ras K-RAS K-ras c-bas/has KRAS RRAS

MRAS HRAS RERG RAP1B RALB DKFZp547A0616

RAP2B RALA RAP2A RAP1A NRAS DKFZp686J06205

RRAS2 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for RRAS2
PGOHUM00000234921 PGOHUM00000240534

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113954997^1,2	C	other	14316390(-)	`AGGACA/C/TAGAAG`	20	Q P L	mis¹ ut5¹		1		CSA	2
rs143701340^1,2		--	14299098(+)	`TGTGCA/GCCACT`	4	--	ds500¹		0	--	--	--	--
rs74964973^1,2	F,	--	14299149(+)	`AATGTG/ATGTGT`	4	--	ds500¹		1		NA	120
rs138438317^1,2		--	14299299(+)	`AAAGAA/TCATCA`	4	--	ds500¹		0	--	--	--	--
rs114001805^1,2	F,	--	14299328(+)	`CCACCT/GGCTGA`	4	--	ds500¹		1		WA	118
rs142979637^1,2		--	14299610(+)	`TACTAC/TTGAAT`	4	--	ut3¹		0	--	--	--	--
rs55872041^1,2	C	--	14299635(+)	`CCACAA/GAATTA`	4	--	ut3¹		0	--	--	--	--
rs185822496^1,2		--	14299721(+)	`TCAATA/GTCTAG`	4	--	ut3¹		0	--	--	--	--
rs190530669^1,2		--	14299728(+)	`CTAGCA/CGGGAA`	4	--	ut3¹		0	--	--	--	--
rs181091124^1,2		--	14299759(+)	`TCTCAC/TCCTGT`	4	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RRAS2 (14299466 - 14386052 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for RRAS2
6 Indels: 24678 65873 11540 42636 39807 61105

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RRAS2

DNA2.0 Custom Variant and Variant Library Synthesis for RRAS2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RRAS2 for disorders About GeneDecksing

OMIM gene information: 600098 OMIM disorders: --

UniProtKB/Swiss-Prot: RRAS2_HUMAN, P62070

Defects in RRAS2 are a cause of susceptibility to ovarian cancer (OC) [MIM:167000]. The term ovarian cancer

defines common malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have

been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the

recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with

advanced disease

12 diseases for RRAS2: About MalaCards

teratocarcinoma oral squamous cell carcinoma squamous cell carcinoma leiomyosarcoma

skin cancer parkinson's disease breast cancer hermaphroditism

hepatocellular carcinoma carcinoma esophagitis glioblastoma

2 Novoseek disease relationships for RRAS2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	23.4	15	19047159 (2), 7478545 (2), 8552388 (1), 11340168 (1) (see all 6)
breast cancer	14.6	2	19047159 (2)

Human Genome Epidemiology (HuGE) Navigator: RRAS2 (3 documents)

Export disorders for RRAS2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RRAS2 gene, integrated from 9 sources (see all 56):
(articles sorted by number of sources associating them with RRAS2)

Utopia: connect your pdf to the dynamic
world of online information

A human oncogene of the RAS superfamily unmasked by expression cDNA cloning. (PubMed id 8052619)^{1, 2, 3} Chan A.M....Aaronson S.A. (1994)
Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line. (PubMed id 2108320)^{1, 2, 3} Drivas G.T.... D'Eustachio P. (1990)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. (PubMed id 15308774)^{1, 2} Kho Y.... Zhao Y. (2004)
Structural and spatial determinants regulating TC21 a ctivation by RasGRF family nucleotide exchange factors. (PubMed id 19692568)^{1, 9} Calvo F. and Crespo P. (2009)
Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells. (PubMed id 10064593)^{1, 9} Rosario M....Marshall C.J. (1999)
A polymorphism in the TC21 promoter associates with an unfavorable tamoxifen treatment outcome in breast cancer. (PubMed id 19047159)^{1, 9} Rokavec M....Brauch H. (2008)
Signaling pathways regulating TC21-induced tumorigenesis. (PubMed id 17656362)^{1, 9} Erdogan M....Zent R. (2007)
Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3. (PubMed id 10777492)^{1, 9} Ohba Y....Matsuda M. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 22800	HGNC: 17271	AceView: RRAS2	Ensembl:ENSG00000133818	euGenes: HUgn22800
ECgene: RRAS2	Kegg: 22800	H-InvDB: RRAS2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RRAS2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RRAS2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RRAS2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RRAS2 gene:
Search GeneIP for patents involving RRAS2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for RRAS2 (TC21/R-Ras2)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for RRAS2		OriGene shRNA RFP for RRAS2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RRAS2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RRAS2
	OriGene Protein Over-expression Lysate for RRAS2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for RRAS2		OriGene 3'-UTR Clone for RRAS2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RRAS2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RRAS2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for RRAS2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for RRAS2		OriGene Custom Protein Services for RRAS2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RRAS2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RRAS2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RRAS2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RRAS2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RRAS2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RRAS2

	GenScript Custom Purified and Recombinant Proteins Services for RRAS2		GenScript cDNA clones with any tag delivered in your preferred vector for RRAS2
	GenScript Custom Assay Services for RRAS2		GenScript Custom Superior Antibodies Services for RRAS2
	GenScript Custom overexpressing Cell Line Services for RRAS2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in RRAS2 promoter
	Search Chromatin IP Primers for RRAS2
	RT² qPCR Primer Assay in human, mouse, rat RRAS2
	GNC Network for RRAS2
	SABiosciences PCR Arrays including human, mouse, rat RRAS2

Search Tocris compounds for RRAS2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	RRAS2 antibodies
	RRAS2 proteins
	RRAS2 lysates

	Search for Antibodies for RRAS2 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for RRAS2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for RRAS2

RRAS2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for RRAS2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRAS2

	SwitchGear 3'UTR luciferase reporter plasmids for RRAS2
	Browse SwitchGear Promoter luciferase reporter plasmids for RRAS2

ThermoFisher Antibody for RRAS2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRAS2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RRAS2 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

RRAS2 Gene

related RAS viral (r-ras) oncogene homolog 2

Aliases
for RRAS2 gene

Summaries
for RRAS2 gene

Genomic Views
for RRAS2 gene

Proteins
for RRAS2 gene

Protein Domains /
Families
for RRAS2 gene

Function
for RRAS2 gene

Pathways & Interactions
for RRAS2 gene

Drugs & Compounds
for RRAS2 gene

Transcripts
for RRAS2 gene

Expression
for RRAS2 gene

Orthologs
for RRAS2 gene

Paralogs
for RRAS2 gene

Genomic Variants
for RRAS2 gene

Disorders / Diseases
for RRAS2 gene

Publications
for RRAS2 gene

External Searches for RRAS2 gene

Genome Databases showing RRAS2 gene

Other Databases showing RRAS2 gene

Specialized Databases showing RRAS2 gene

Intellectual Property
for RRAS2 gene

Products
for RRAS2 gene

View Random Gene

Advanced Search

Export list of displayed genes

RRAS2 Gene

related RAS viral (r-ras) oncogene homolog 2

Aliasesfor RRAS2 gene

Summariesfor RRAS2 gene

Genomic Viewsfor RRAS2 gene

Proteinsfor RRAS2 gene

Protein Domains /Familiesfor RRAS2 gene

Functionfor RRAS2 gene

Pathways & Interactionsfor RRAS2 gene

Drugs & Compoundsfor RRAS2 gene

Transcriptsfor RRAS2 gene

Expression for RRAS2 gene

Orthologsfor RRAS2 gene

Paralogsfor RRAS2 gene

Genomic Variantsfor RRAS2 gene

Disorders / Diseasesfor RRAS2 gene

Publicationsfor RRAS2 gene

External Searches for RRAS2 gene

Genome Databases showing RRAS2 gene

Other Databases showing RRAS2 gene

Specialized Databases showing RRAS2 gene

Intellectual Propertyfor RRAS2 gene

Productsfor RRAS2 gene

View Random Gene

Aliases
for RRAS2 gene

Summaries
for RRAS2 gene

Genomic Views
for RRAS2 gene

Proteins
for RRAS2 gene

Protein Domains /
Families
for RRAS2 gene

Function
for RRAS2 gene

Pathways & Interactions
for RRAS2 gene

Drugs & Compounds
for RRAS2 gene

Transcripts
for RRAS2 gene

Expression
for RRAS2 gene

Orthologs
for RRAS2 gene

Paralogs
for RRAS2 gene

Genomic Variants
for RRAS2 gene

Disorders / Diseases
for RRAS2 gene

Publications
for RRAS2 gene

Intellectual Property
for RRAS2 gene

Products
for RRAS2 gene