 |
 | Services
| |
 |
Aliases & Descriptions for RRAS
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| Oncogene RRAS 2 | | related RAS viral (r-ras) oncogene homolog 2 |
|
| | Search outside databases for aliases for RRAS genePrevious GC identifers: GC19M050796 GC19M050506 GC19M054814 |
Summaries for RRAS(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: RRAS_HUMAN, P10301Function: Regulates the organization of the actin cytoskeletonGene Wiki entry for RRAS |
Genomic Location for RRAS
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RRAS gene 
Entrez Gene cytogenetic band: 19q13.3-qter Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.3-qterRRAS Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M054830:
(about GC identifiers)
Start:
|
54,830,364 bp from pter |
End:
|
54,835,212 bp from pter |
Size:
|
4,849 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011109.15
| Proteins for RRAS
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RRAS_HUMAN, P10301 (See
protein sequence)Recommended Name: Ras-related protein R-Ras precursor Size: 218 amino acids; 23480 Da
Subunit: Interacts with PLCE1
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS)
PDB structures from and Proteopedia :2FN4 (3D)
 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_006261.1
ENSEMBL proteins: ENSP00000246792
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: RRAS 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- | | GO:0005886 | plasma membrane |
IEA | -- | About this table
Antibodies for RRAS: Assays for RRAS: | Protein
Domains/ Families for RRAS(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P10301
ProtoNet protein and cluster: P10301 2 Blocks protein families: IPB001806 Transforming protein P21 RAS signature IPB003577 Ras small GTPase
UniProtKB/Swiss-Prot: RRAS_HUMAN, P10301Similarity: Belongs to the small GTPase superfamily. Ras family | Gene Function for RRAS
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006270
Applied Biosystems Silencer® siRNAs for RRAS
Sigma-Aldrich siRNA for RRAS  Sigma-Aldrich shRNA Panels and shRNA for RRAS  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006270                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006270                                  untagged cDNA clone in CMV expression vector: NM_006270 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006270
UniProtKB/Swiss-Prot: RRAS_HUMAN, P10301Function: Regulates the organization of the actin cytoskeletonGenatlas biochemistry entry for RRAS:Ras oncogene homolog,related,tightly linked to a full size LTR of human endogenous retroviruses HERV-K,regulating the binding of integrins to their ligands,outside the cells,phosphorylated by EPHR1 and no longer supporting integrin activity2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Rras):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for RRAS
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/88 Sigma-Aldrich "Your Favorite Gene" Pathways for RRAS (Your Favorite Gene powered by Ingenuity) (see all 88
) 
Gene Network CentralTM Interacting Genes and Proteins Network for RRAS 
5/51 Interacting proteins for RRAS (P103011 ENSP000002467923) via UniProtKB, MINT, and/or STRING (see all 51
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007265 | Ras protein signal transduction |
TAS | 3098437 | | GO:0030336 | negative regulation of cell migration |
IEA | -- | About this table
|
Drugs & Compounds for RRAS(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for RRAS 8 Novoseek chemical compound relationships for RRAS gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gdp |
63.10 |
8 |
9228027 (1), 7744959 (1), 10835426 (1), 16754664 (1) (see all 6) |
| gtp |
54.76 |
15 |
18784646 (3), 16522685 (2), 10671570 (2), 18270166 (1) (see all 8) |
| phosphatidylinositol |
51.34 |
7 |
12805072 (1), 10454580 (1), 10352023 (1), 10801791 (1) (see all 5) |
| tyrosine |
20.04 |
4 |
10570155 (2), 11682467 (1) |
| proline |
12.12 |
6 |
10671570 (5) |
| threonine |
5.93 |
1 |
8999998 (1) |
| glycogen |
5.79 |
2 |
17107957 (1), 16799460 (1) |
| lipid |
0.00 |
3 |
8999998 (1), 14623256 (1) |
About this table
|
Transcripts for RRAS(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006270
Sigma-Aldrich siRNA for RRAS  Sigma-Aldrich shRNA Panels and shRNA for RRAS  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006270 REFSEQ mRNAs for RRAS gene: NM_006270.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006270               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006270                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006270                                  untagged cDNA clone in CMV expression vector: NM_006270  Additional cDNA sequence: AF493920.1 BC016286.1 BC016318.1 BT006805.1 CR541944.1 CR541967.1 CR626325.1 6 DOTS entries: DT.413325 DT.92429822 DT.95191234 DT.100740241 DT.121505267 DT.95191264 24/165 AceView cDNA sequences (see all 165
):BF591029 BC016318 BT006805 AI399744 BU624215 W51840 AI828629 AI969219 AI480089 AI815073 AI368184 BQ227915 BC016286 AI648524 AI675908 AA315712 AI658480 AI804197 CR626325 AW069039 AI201108 BF591022 BX357198 AA640176
highest scoring ESTs for RRAS:AF493920 BC016286 BC016318 BE019471 BE019479 BE268545 BE268682 BE298046 BE397417 BE615949 Unigene Cluster for RRAS: Related RAS viral (r-ras) oncogene homolog Hs.515536 [show with all ESTs]Unigene Representative Sequence: BF965156
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for RRAS
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | |
| SP1: | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for RRAS
1 Ensembl transcript including schematic representation: ENST00000246792
|
Expression for RRAS
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RRAS expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RRAS
1 / 2 / 3 5 probe-sets matching RRAS gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CGTGCTGGCC
SOURCE GeneReport for Unigene cluster: Hs.515536
Expression variation in blood from EXPOLDB for RRAS |
Orthologs for RRAS
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RRAS gene from 5/8 species (see all 8
)
About this table Species with no ortholog for RRAS
ENSEMBL Gene Tree for RRAS | Paralogs for RRAS(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RRAS gene
- RIT22 RRAS22 MRAS2 RIT12
|
SNPs/Variants for RRAS(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
The following additional 22 SNP(s) have been
found in Applied Biosystems data source: (Click
for
Applied Biosystems TaqMan ® Genotyping Assay)
HapMap Linkage Disequilibrium images for RRAS (up to first 250kb)
|
Disorders & Mutations for RRAS
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 165090
2 Novoseek disease relationships for RRAS gene
About this table
|
Medical News for RRAS(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RRAS (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/82 PubMed articles for RRAS gene (see all 82
):- Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes. (PubMed id 3098437)2, 3, 4 Lowe D.G....Goeddel D.V. (1987)
- The small GTPase R-Ras regulates organization of actin and drives membrane protrusions through the activity of PLCepsilon. (PubMed id 16537651)3, 4 Ada-Nguema A.S.... Keely P.J. (2006)
- Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. (PubMed id 15242332)3, 4 Aboulaich N.... Vener A.V. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras. (PubMed id 10671570)1, 3 Wang B....Ruoslahti E. (2000)
- R-Ras controls membrane protrusion and cell migration through the spatial regulation of Rac and Rho. (PubMed id 15525681)1, 3 Wozniak M.A....Keely P.J. (2005)
- Cyclic AMP-dependent and Epac-mediated activation of R-Ras by G protein-coupled receptors leads to phospholipase D stimulation. (PubMed id 16754664)1, 3 Lopez De Jesus M....Schmidt M. (2006)
- R-Ras promotes focal adhesion formation through focal adhesion kinase and p130(Cas) by a novel mechanism that differs from integrins. (PubMed id 12529399)1, 3 Kwong L....Keely P.J. (2003)
- The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function. (PubMed id 11042683)1, 3 Oertli B....Hughes P.E. (2000)
- Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3. (PubMed id 10777492)1, 3 Ohba Y....Matsuda M. (2000)
|
Search for RRAS
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RRAS
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RRAS
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RRAS(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RRAS(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RRAS:

 | |
 | | | | |
|
 |  |  |
| Antibodies & Assays for RRAS  (R-ras) |
| | Recombinant Proteins (RRAS) | | Antibodies (RRAS) |
| | | Search Tocris compounds for RRAS |
|
 |
 | | | |
GeneCards Homepage - Last full update: 1 Jul 2009
Incremental update: 13 Oct 2009
|