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Aliases for RRAS Gene

Aliases for RRAS Gene

  • RAS Related 2 3
  • Related RAS Viral (R-Ras) Oncogene Homolog 2 3 5
  • Oncogene RRAS 2 3
  • P23 3 4
  • Ras Family Small GTP Binding Protein R-Ras 3
  • Ras-Related Protein R-Ras 3
  • R-Ras 3

External Ids for RRAS Gene

Previous GeneCards Identifiers for RRAS Gene

  • GC19M050796
  • GC19M050506
  • GC19M054814
  • GC19M054830
  • GC19M050138
  • GC19M046515

Summaries for RRAS Gene

Entrez Gene Summary for RRAS Gene

  • The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015]

GeneCards Summary for RRAS Gene

RRAS (RAS Related) is a Protein Coding gene. Diseases associated with RRAS include Noonan Syndrome 1 and Juvenile Myelomonocytic Leukemia. Among its related pathways are Arrhythmogenic right ventricular cardiomyopathy (ARVC) and Semaphorin interactions. GO annotations related to this gene include GTP binding and protein complex binding. An important paralog of this gene is RRAS2.

UniProtKB/Swiss-Prot for RRAS Gene

  • Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267).

Gene Wiki entry for RRAS Gene

Additional gene information for RRAS Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRAS Gene

Genomics for RRAS Gene

Regulatory Elements for RRAS Gene

Enhancers for RRAS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H050496 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.4 -859.1 -859147 6.1 GLI4 TCF12 GLIS2 GATA2 ZNF202 REST MEF2D GLIS1 NBN NR2C1 PRR12 NUP62 CTU1 NR1H2 ENSG00000268047 RRAS POLD1 ADM5 PTOV1 AKT1S1
GH19H048871 1.7 Ensembl ENCODE dbSUPER 13.4 +764.2 764187 8.8 FEZF1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A MEF2D SSRP1 ZNF610 GLIS1 PRR12 SNRNP70 IRF3 GRWD1 SNORD35A PIH1D1 SNORD35B PTOV1-AS2 ALDH16A1 KDELR1
GH19H050311 1.5 Ensembl ENCODE dbSUPER 13.4 -674.1 -674071 5.2 HDGF PKNOX1 ATF1 GLI4 ZNF2 ZBTB7B BRCA1 ZNF121 GLIS2 ELK1 CPT1C LRRC4B NR1H2 RRAS SHANK1 PTOV1 ENSG00000268231 KCNC3 MYH14 PIR40912
GH19H050383 1.4 FANTOM5 ENCODE 13.4 -744.4 -744424 3.2 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 SP3 C19orf81 NR1H2 RRAS PRR12 CTU1 PRMT1 ENSG00000268047 NAPSB CLEC11A NUP62
GH19H050510 1.4 ENCODE dbSUPER 13.4 -871.1 -871093 2.5 HDGF PKNOX1 ARNT SIN3A ZNF2 YY1 CBX5 ZNF207 ZNF143 DEK NR1H2 RRAS PRR12 CTU1 PRMT1 NAPSB ENSG00000268047 ASPDH CLEC11A NUP62
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RRAS on UCSC Golden Path with GeneCards custom track

Genomic Locations for RRAS Gene

Genomic Locations for RRAS Gene
4,910 bases
Minus strand

Genomic View for RRAS Gene

Genes around RRAS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRAS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRAS Gene

Proteins for RRAS Gene

  • Protein details for RRAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein R-Ras
    Protein Accession:
    Secondary Accessions:
    • Q6FH12

    Protein attributes for RRAS Gene

    218 amino acids
    Molecular mass:
    23480 Da
    Quaternary structure:
    • Interacts with PLCE1 (PubMed:16537651). Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts with OSBPL3 (PubMed:18270267).

    Three dimensional structures from OCA and Proteopedia for RRAS Gene

neXtProt entry for RRAS Gene

Post-translational modifications for RRAS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RRAS Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RRAS (RRas)
  • Abcam antibodies for RRAS
  • Santa Cruz Biotechnology (SCBT) Antibodies for RRAS

No data available for DME Specific Peptides for RRAS Gene

Domains & Families for RRAS Gene

Gene Families for RRAS Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RRAS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Ras family.
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RRAS: view

Function for RRAS Gene

Molecular function for RRAS Gene

GENATLAS Biochemistry:
Ras oncogene homolog,related,tightly linked to a full size LTR of human endogenous retroviruses HERV-K,regulating the binding of integrins to their ligands,outside the cells,phosphorylated by EPHR1 and no longer supporting integrin activity
UniProtKB/Swiss-Prot Function:
Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267).

Phenotypes From GWAS Catalog for RRAS Gene

Gene Ontology (GO) - Molecular Function for RRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS,IMP 24705357
GO:0005515 protein binding IPI 17474147
GO:0005525 GTP binding IEA --
GO:0019003 GDP binding IMP 24705357
GO:0032403 protein complex binding IDA 23209302
genes like me logo Genes that share ontologies with RRAS: view
genes like me logo Genes that share phenotypes with RRAS: view

Animal Model Products

CRISPR Products

miRNA for RRAS Gene

miRTarBase miRNAs that target RRAS

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RRAS

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRAS Gene

Localization for RRAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRAS Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRAS gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 3
cytosol 3
cytoskeleton 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with RRAS: view

Pathways & Interactions for RRAS Gene

genes like me logo Genes that share pathways with RRAS: view

SIGNOR curated interactions for RRAS Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for RRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002521 leukocyte differentiation IMP 24705357
GO:0007165 signal transduction IEA --
GO:0007265 Ras protein signal transduction TAS 3098437
GO:0030336 negative regulation of cell migration IEA --
GO:0045766 positive regulation of angiogenesis IMP 21393242
genes like me logo Genes that share ontologies with RRAS: view

Drugs & Compounds for RRAS Gene

(6) Drugs for RRAS Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for RRAS Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RRAS: view

Transcripts for RRAS Gene

mRNA/cDNA for RRAS Gene

Unigene Clusters for RRAS Gene

Related RAS viral (r-ras) oncogene homolog:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RRAS

Alternative Splicing Database (ASD) splice patterns (SP) for RRAS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6

Relevant External Links for RRAS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RRAS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RRAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RRAS Gene

This gene is overexpressed in Prostate (10.0) and Urinary Bladder (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RRAS Gene

Protein tissue co-expression partners for RRAS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RRAS Gene:


SOURCE GeneReport for Unigene cluster for RRAS Gene:


Evidence on tissue expression from TISSUES for RRAS Gene

  • Nervous system(4.4)
  • Liver(4.3)
  • Heart(2.5)
  • Muscle(2.3)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with RRAS: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RRAS Gene

Orthologs for RRAS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RRAS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RRAS 33 34
  • 99.54 (n)
(Canis familiaris)
Mammalia RRAS 33 34
  • 91.9 (n)
(Bos Taurus)
Mammalia RRAS 33 34
  • 90.67 (n)
(Mus musculus)
Mammalia Rras 33 16 34
  • 88.23 (n)
(Rattus norvegicus)
Mammalia Rras 33
  • 88.23 (n)
(Monodelphis domestica)
Mammalia RRAS 34
  • 68 (a)
(Anolis carolinensis)
Reptilia RRAS 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rras 33
  • 67.89 (n)
(Danio rerio)
Actinopterygii rras 34 33
  • 67.54 (n)
wufb23a02 33
fruit fly
(Drosophila melanogaster)
Insecta Ras64B 35 34
  • 68 (a)
(Caenorhabditis elegans)
Secernentea ras-1 34 35
  • 56 (a)
ras-2 35
  • 51 (a)
C08F8.7 35
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAS1 34
  • 35 (a)
RAS2 34
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 60 (a)
Species where no ortholog for RRAS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRAS Gene

Gene Tree for RRAS (if available)
Gene Tree for RRAS (if available)

Paralogs for RRAS Gene

Variants for RRAS Gene

Sequence variations from dbSNP and Humsavar for RRAS Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000205836 -- 49,637,785(+) CCCCT(C/T)CTACC intron-variant
rs1000674026 -- 49,637,302(+) GAGTC(-/TTTTTTTTT)TTTTT intron-variant
rs1001974225 -- 49,635,937(+) GATAC(C/T)CTAGG intron-variant
rs1002145706 -- 49,641,908(+) TTCCG(C/T)GCGCG intron-variant, upstream-variant-2KB
rs1002712238 -- 49,640,737(+) GAGGA(A/G)AGTGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RRAS Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV gain+loss 18304495
nsv953600 CNV deletion 24416366
nsv833865 CNV gain+loss 17160897
nsv833864 CNV gain 17160897
nsv828578 CNV loss 20364138
nsv817854 CNV gain 17921354
nsv470150 CNV gain 18288195
nsv469715 CNV gain+loss 16826518
nsv1160655 CNV deletion 26073780

Variation tolerance for RRAS Gene

Residual Variation Intolerance Score: 50.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRAS Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRAS Gene

Disorders for RRAS Gene

MalaCards: The human disease database

(3) MalaCards diseases for RRAS Gene - From: HGMD, Orphanet, and DISEASES

Disorder Aliases PubMed IDs
noonan syndrome 1
  • ns1
juvenile myelomonocytic leukemia
  • leukemia, juvenile myelomonocytic, somatic
eastern equine encephalitis
  • eee
- elite association - COSMIC cancer census association via MalaCards
Search RRAS in MalaCards View complete list of genes associated with diseases

Relevant External Links for RRAS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RRAS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RRAS Gene

Publications for RRAS Gene

  1. Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes. (PMID: 3098437) Lowe DG … Goeddel DV (Cell 1987) 2 3 4 60
  2. Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras. (PMID: 20385769) Sakurai A … Gutkind JS (Molecular and cellular biology 2010) 3 22 60
  3. Transcription factor 8 activates R-Ras to regulate angiogenesis. (PMID: 19116136) Inuzuka T … Ohba Y (Biochemical and biophysical research communications 2009) 3 22 60
  4. Structure and function of the intracellular region of the plexin-b1 transmembrane receptor. (PMID: 19843518) Tong Y … Buck M (The Journal of biological chemistry 2009) 3 22 60
  5. The R-Ras interaction partner ORP3 regulates cell adhesion. (PMID: 18270267) Lehto M … Olkkonen VM (Journal of cell science 2008) 4 22 60

Products for RRAS Gene

  • Addgene plasmids for RRAS

Sources for RRAS Gene

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