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Aliases for RRAS Gene

Aliases for RRAS Gene

  • Related RAS Viral (R-Ras) Oncogene Homolog 2 3 5
  • Oncogene RRAS 2 3
  • P23 3 4
  • Ras Family Small GTP Binding Protein R-Ras 3
  • Ras-Related Protein R-Ras 3

External Ids for RRAS Gene

Previous GeneCards Identifiers for RRAS Gene

  • GC19M050796
  • GC19M050506
  • GC19M054814
  • GC19M054830
  • GC19M050138
  • GC19M046515

Summaries for RRAS Gene

Entrez Gene Summary for RRAS Gene

  • The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015]

GeneCards Summary for RRAS Gene

RRAS (Related RAS Viral (R-Ras) Oncogene Homolog) is a Protein Coding gene. Diseases associated with RRAS include Eastern Equine Encephalitis and Tick Infestation. Among its related pathways are Bisphosphonate Pathway, Pharmacodynamics and GPCR Pathway. GO annotations related to this gene include GTP binding and protein complex binding. An important paralog of this gene is RRAS2.

UniProtKB/Swiss-Prot for RRAS Gene

  • Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267).

Gene Wiki entry for RRAS Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRAS Gene

Genomics for RRAS Gene

Regulatory Elements for RRAS Gene

Enhancers for RRAS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G048880 1.5 Ensembl ENCODE dbSUPER 18.1 +758.7 758676 1.8 ATF1 CREB3L1 ETS1 ZNF121 ZNF766 ELK1 ZNF143 KLF13 CAVIN1 ZNF592 RRAS TULP2 PRR12 EMP3 NUCB1 FLT3LG TEAD2 ENSG00000268157 IRF3 GC19M048876
GH19G049987 1.2 ENCODE 18.1 -347.1 -347098 0.2 MLX CREB3L1 ZFP64 DMAP1 SLC30A9 ZNF143 ZNF263 NFYC TBX21 MEF2D VRK3 PRR12 FLT3LG RRAS NR1H2 ENSG00000268047 ENSG00000221125 ZNF473 CLEC11A TEAD2
GH19G049486 1.7 Ensembl ENCODE dbSUPER 5 +150.0 149962 7.5 CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF416 SP3 NFYC RPS11 NUP62 PRR12 ALDH16A1 SNORD35B FLT3LG SNORD35A PIH1D1 POLD1 RPL18
GH19G049855 1 ENCODE 5.4 -215.6 -215563 1.1 ATF1 PKNOX1 CREB3L1 ARNT AGO1 SIN3A YY1 GLIS2 ELK1 KLF7 PNKP FLT3LG FCGRT RRAS ENSG00000268047 GC19P049856
GH19G049637 1.8 FANTOM5 ENCODE dbSUPER 2.9 -0.5 -453 6.4 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 PRMT1 ADM5 CPT1C PRR12 RRAS RCN3 AP2A1 TRPM4 AKT1S1 SCAF1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RRAS on UCSC Golden Path with GeneCards custom track

Promoters for RRAS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110930 -899 3801 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263

Genomic Location for RRAS Gene

Chromosome:
19
Start:
49,635,292 bp from pter
End:
49,640,201 bp from pter
Size:
4,910 bases
Orientation:
Minus strand

Genomic View for RRAS Gene

Genes around RRAS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRAS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRAS Gene

Proteins for RRAS Gene

  • Protein details for RRAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10301-RRAS_HUMAN
    Recommended name:
    Ras-related protein R-Ras
    Protein Accession:
    P10301
    Secondary Accessions:
    • Q6FH12

    Protein attributes for RRAS Gene

    Size:
    218 amino acids
    Molecular mass:
    23480 Da
    Quaternary structure:
    • Interacts with PLCE1 (PubMed:16537651). Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts with OSBPL3 (PubMed:18270267).

    Three dimensional structures from OCA and Proteopedia for RRAS Gene

neXtProt entry for RRAS Gene

Post-translational modifications for RRAS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RRAS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RRAS Gene

Domains & Families for RRAS Gene

Gene Families for RRAS Gene

Suggested Antigen Peptide Sequences for RRAS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10301

UniProtKB/Swiss-Prot:

RRAS_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RRAS: view

Function for RRAS Gene

Molecular function for RRAS Gene

GENATLAS Biochemistry:
Ras oncogene homolog,related,tightly linked to a full size LTR of human endogenous retroviruses HERV-K,regulating the binding of integrins to their ligands,outside the cells,phosphorylated by EPHR1 and no longer supporting integrin activity
UniProtKB/Swiss-Prot Function:
Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267).

Gene Ontology (GO) - Molecular Function for RRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS,IMP 24705357
GO:0005515 protein binding IPI 17474147
GO:0005525 GTP binding IEA --
GO:0019003 GDP binding IMP 24705357
GO:0032403 protein complex binding IDA 23209302
genes like me logo Genes that share ontologies with RRAS: view
genes like me logo Genes that share phenotypes with RRAS: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RRAS

miRNA for RRAS Gene

miRTarBase miRNAs that target RRAS

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RRAS

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRAS Gene

Localization for RRAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRAS Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRAS gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 3
cytosol 3
cytoskeleton 1
endosome 1

Gene Ontology (GO) - Cellular Components for RRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with RRAS: view

Pathways & Interactions for RRAS Gene

genes like me logo Genes that share pathways with RRAS: view

SIGNOR curated interactions for RRAS Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for RRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002521 leukocyte differentiation IMP 24705357
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007265 Ras protein signal transduction TAS 3098437
GO:0030336 negative regulation of cell migration IEA --
genes like me logo Genes that share ontologies with RRAS: view

Drugs & Compounds for RRAS Gene

(6) Drugs for RRAS Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for RRAS Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RRAS: view

Transcripts for RRAS Gene

mRNA/cDNA for RRAS Gene

Unigene Clusters for RRAS Gene

Related RAS viral (r-ras) oncogene homolog:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RRAS

Alternative Splicing Database (ASD) splice patterns (SP) for RRAS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2:

Relevant External Links for RRAS Gene

GeneLoc Exon Structure for
RRAS
ECgene alternative splicing isoforms for
RRAS

Expression for RRAS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RRAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RRAS Gene

This gene is overexpressed in Prostate (10.0) and Urinary Bladder (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RRAS Gene



Protein tissue co-expression partners for RRAS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RRAS Gene:

RRAS

SOURCE GeneReport for Unigene cluster for RRAS Gene:

Hs.515536

Evidence on tissue expression from TISSUES for RRAS Gene

  • Nervous system(4.4)
  • Liver(4.3)
  • Heart(2.4)
  • Muscle(2.3)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with RRAS: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RRAS Gene

Orthologs for RRAS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RRAS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RRAS 34 35
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia RRAS 34 35
  • 91.9 (n)
cow
(Bos Taurus)
Mammalia RRAS 34 35
  • 90.67 (n)
mouse
(Mus musculus)
Mammalia Rras 34 16 35
  • 88.23 (n)
rat
(Rattus norvegicus)
Mammalia Rras 34
  • 88.23 (n)
oppossum
(Monodelphis domestica)
Mammalia RRAS 35
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RRAS 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rras 34
  • 67.89 (n)
zebrafish
(Danio rerio)
Actinopterygii rras 34 35
  • 67.54 (n)
wufb23a02 34
fruit fly
(Drosophila melanogaster)
Insecta Ras64B 36 35
  • 68 (a)
worm
(Caenorhabditis elegans)
Secernentea ras-1 36 35
  • 64 (a)
ras-2 36
  • 51 (a)
C08F8.7 36
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAS1 35
  • 35 (a)
ManyToMany
RAS2 35
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 60 (a)
OneToMany
Species where no ortholog for RRAS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRAS Gene

ENSEMBL:
Gene Tree for RRAS (if available)
TreeFam:
Gene Tree for RRAS (if available)

Paralogs for RRAS Gene

Variants for RRAS Gene

Sequence variations from dbSNP and Humsavar for RRAS Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000205836 -- 49,637,785(+) CCCCT(C/T)CTACC intron-variant
rs1000674026 -- 49,637,302(+) GAGTC(-/TTTTTTTTT)TTTTT intron-variant
rs1001974225 -- 49,635,937(+) GATAC(C/T)CTAGG intron-variant
rs1002145706 -- 49,641,908(+) TTCCG(C/T)GCGCG intron-variant, upstream-variant-2KB
rs1002712238 -- 49,640,737(+) GAGGA(A/G)AGTGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RRAS Gene

Variant ID Type Subtype PubMed ID
nsv1160655 CNV deletion 26073780
nsv469715 CNV gain+loss 16826518
nsv470150 CNV gain 18288195
nsv817854 CNV gain 17921354
nsv828578 CNV loss 20364138
nsv833864 CNV gain 17160897
nsv833865 CNV gain+loss 17160897
nsv953600 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for RRAS Gene

Residual Variation Intolerance Score: 50.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRAS Gene

Human Gene Mutation Database (HGMD)
RRAS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RRAS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRAS Gene

Disorders for RRAS Gene

MalaCards: The human disease database

(2) MalaCards diseases for RRAS Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
eastern equine encephalitis
  • eee
tick infestation
  • tick infestations
- elite association - COSMIC cancer census association via MalaCards
Search RRAS in MalaCards View complete list of genes associated with diseases

Relevant External Links for RRAS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RRAS
genes like me logo Genes that share disorders with RRAS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RRAS Gene

Publications for RRAS Gene

  1. Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes. (PMID: 3098437) Lowe D.G. … Goeddel D.V. (Cell 1987) 2 3 4 64
  2. Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras. (PMID: 20385769) Sakurai A. … Gutkind J.S. (Mol. Cell. Biol. 2010) 3 22 64
  3. Transcription factor 8 activates R-Ras to regulate angiogenesis. (PMID: 19116136) Inuzuka T. … Ohba Y. (Biochem. Biophys. Res. Commun. 2009) 3 22 64
  4. Structure and function of the intracellular region of the plexin-B1 transmembrane receptor. (PMID: 19843518) Tong Y. … Buck M. (J. Biol. Chem. 2009) 3 22 64
  5. The R-Ras interaction partner ORP3 regulates cell adhesion. (PMID: 18270267) Lehto M. … Olkkonen V.M. (J. Cell. Sci. 2008) 4 22 64

Products for RRAS Gene

  • Addgene plasmids for RRAS

Sources for RRAS Gene

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