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Aliases for RRAS Gene

Aliases for RRAS Gene

  • Related RAS Viral (R-Ras) Oncogene Homolog 2 3 5
  • Oncogene RRAS 2 3
  • P23 3 4
  • Ras Family Small GTP Binding Protein R-Ras 3

External Ids for RRAS Gene

Previous GeneCards Identifiers for RRAS Gene

  • GC19M050796
  • GC19M050506
  • GC19M054814
  • GC19M054830
  • GC19M050138
  • GC19M046515

Summaries for RRAS Gene

Entrez Gene Summary for RRAS Gene

  • The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015]

GeneCards Summary for RRAS Gene

RRAS (Related RAS Viral (R-Ras) Oncogene Homolog) is a Protein Coding gene. Diseases associated with RRAS include Tick Infestation and Gemistocytic Astrocytoma. Among its related pathways are IL-2 Pathway and Axon guidance. GO annotations related to this gene include GTP binding and protein complex binding. An important paralog of this gene is HRAS.

UniProtKB/Swiss-Prot for RRAS Gene

  • Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267).

Gene Wiki entry for RRAS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRAS Gene

Genomics for RRAS Gene

Regulatory Elements for RRAS Gene

Enhancers for RRAS Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RRAS on UCSC Golden Path with GeneCards custom track

Promoters for RRAS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RRAS on UCSC Golden Path with GeneCards custom track

Genomic Location for RRAS Gene

49,635,292 bp from pter
49,640,201 bp from pter
4,910 bases
Minus strand

Genomic View for RRAS Gene

Genes around RRAS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRAS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRAS Gene

Proteins for RRAS Gene

  • Protein details for RRAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein R-Ras
    Protein Accession:
    Secondary Accessions:
    • Q6FH12

    Protein attributes for RRAS Gene

    218 amino acids
    Molecular mass:
    23480 Da
    Quaternary structure:
    • Interacts with PLCE1 (PubMed:16537651). Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts with OSBPL3 (PubMed:18270267).

    Three dimensional structures from OCA and Proteopedia for RRAS Gene

neXtProt entry for RRAS Gene

Proteomics data for RRAS Gene at MOPED

Post-translational modifications for RRAS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RRAS Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RRAS (RRas)
  • Abcam antibodies for RRAS

No data available for DME Specific Peptides for RRAS Gene

Domains & Families for RRAS Gene

Gene Families for RRAS Gene

Suggested Antigen Peptide Sequences for RRAS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Ras family.
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RRAS: view

Function for RRAS Gene

Molecular function for RRAS Gene

GENATLAS Biochemistry:
Ras oncogene homolog,related,tightly linked to a full size LTR of human endogenous retroviruses HERV-K,regulating the binding of integrins to their ligands,outside the cells,phosphorylated by EPHR1 and no longer supporting integrin activity
UniProtKB/Swiss-Prot Function:
Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267).
genes like me logo Genes that share phenotypes with RRAS: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RRAS

miRNA for RRAS Gene

miRTarBase miRNAs that target RRAS

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRAS Gene

Localization for RRAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRAS Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).

Subcellular locations from

Jensen Localization Image for RRAS Gene COMPARTMENTS Subcellular localization image for RRAS gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 3
nucleus 3
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for RRAS Gene

Pathways & Interactions for RRAS Gene

genes like me logo Genes that share pathways with RRAS: view

SIGNOR curated interactions for RRAS Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for RRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002521 leukocyte differentiation IMP 24705357
GO:0006913 nucleocytoplasmic transport IEA --
GO:0007411 axon guidance TAS --
GO:0030336 negative regulation of cell migration IEA --
GO:0045766 positive regulation of angiogenesis IMP 21393242
genes like me logo Genes that share ontologies with RRAS: view

Drugs & Compounds for RRAS Gene

(6) Drugs for RRAS Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for RRAS Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RRAS: view

Transcripts for RRAS Gene

mRNA/cDNA for RRAS Gene

Unigene Clusters for RRAS Gene

Related RAS viral (r-ras) oncogene homolog:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RRAS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6

Relevant External Links for RRAS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RRAS Gene

mRNA expression in normal human tissues for RRAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RRAS Gene

This gene is overexpressed in Prostate (10.0) and Urinary Bladder (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RRAS Gene

SOURCE GeneReport for Unigene cluster for RRAS Gene Hs.515536

genes like me logo Genes that share expression patterns with RRAS: view

Protein tissue co-expression partners for RRAS Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RRAS Gene

Orthologs for RRAS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RRAS Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RRAS 35
  • 90.67 (n)
  • 96.79 (a)
  • 97 (a)
(Canis familiaris)
Mammalia RRAS 35
  • 91.9 (n)
  • 97.71 (a)
  • 98 (a)
(Mus musculus)
Mammalia Rras 35
  • 88.23 (n)
  • 94.5 (a)
Rras 16
Rras 36
  • 94 (a)
(Pan troglodytes)
Mammalia RRAS 35
  • 99.54 (n)
  • 99.54 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Rras 35
  • 88.23 (n)
  • 92.66 (a)
(Monodelphis domestica)
Mammalia RRAS 36
  • 68 (a)
(Anolis carolinensis)
Reptilia RRAS 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rras 35
  • 67.89 (n)
  • 74.87 (a)
(Danio rerio)
Actinopterygii rras 35
  • 67.54 (n)
  • 71.73 (a)
wufb23a02 35
rras 36
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ras64B 37
  • 68 (a)
Ras64B 36
  • 64 (a)
(Caenorhabditis elegans)
Secernentea C08F8.7 37
  • 46 (a)
ras-1 37
  • 64 (a)
ras-2 37
  • 51 (a)
ras-1 36
  • 56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAS1 36
  • 35 (a)
RAS2 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
Species with no ortholog for RRAS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRAS Gene

Gene Tree for RRAS (if available)
Gene Tree for RRAS (if available)

Paralogs for RRAS Gene

Paralogs for RRAS Gene

genes like me logo Genes that share paralogs with RRAS: view

Variants for RRAS Gene

Sequence variations from dbSNP and Humsavar for RRAS Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7507455 -- 49,637,232(+) TCTAA(A/C)TGtct intron-variant
rs12978498 -- 49,636,918(+) CGCGG(G/T)GTCCA reference, missense
rs66525253 -- 49,634,947(-) CTGTT(-/TG)TGTGT downstream-variant-500B
rs72243646 -- 49,634,926(+) GAAAA(-/AC)ACACA downstream-variant-500B
rs1368463 -- 49,636,952(-) CCCAC(A/G/T)ATGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RRAS Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833864 CNV Gain 17160897
nsv828578 CNV Loss 20364138
nsv469715 CNV Complex 16826518
nsv833865 CNV Gain+Loss 17160897
nsv912266 CNV Loss 21882294
dgv3972n71 CNV Loss 21882294
nsv912269 CNV Loss 21882294
nsv817854 CNV Gain 17921354
nsv470150 CNV Gain 18288195

Variation tolerance for RRAS Gene

Residual Variation Intolerance Score: 50.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRAS Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRAS Gene

Disorders for RRAS Gene

MalaCards: The human disease database

(3) MalaCards diseases for RRAS Gene - From: DISEASES

Disorder Aliases PubMed IDs
tick infestation
  • tick infestations
gemistocytic astrocytoma
  • gemistocytic astrocytic tumor
eastern equine encephalitis
  • eee
- elite association - COSMIC cancer census association via MalaCards
Search RRAS in MalaCards View complete list of genes associated with diseases

Relevant External Links for RRAS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RRAS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RRAS Gene

Publications for RRAS Gene

  1. Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes. (PMID: 3098437) Lowe D.G. … Goeddel D.V. (Cell 1987) 2 3 4 67
  2. Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras. (PMID: 20385769) Sakurai A. … Gutkind J.S. (Mol. Cell. Biol. 2010) 3 23
  3. Transcription factor 8 activates R-Ras to regulate angiogenesis. (PMID: 19116136) Inuzuka T. … Ohba Y. (Biochem. Biophys. Res. Commun. 2009) 3 23
  4. Structure and function of the intracellular region of the plexin-B1 transmembrane receptor. (PMID: 19843518) Tong Y. … Buck M. (J. Biol. Chem. 2009) 3 23
  5. R-Ras controls axon specification upstream of glycogen synthase kinase-3beta through integrin-linked kinase. (PMID: 17107957) Oinuma I. … Negishi M. (J. Biol. Chem. 2007) 3 23

Products for RRAS Gene

Sources for RRAS Gene