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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RRAS Gene

protein-coding   GIFtS: 63
GCID: GC19M050138

Related RAS Viral (R-Ras) Oncogene Homolog

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Related RAS Viral (R-Ras) Oncogene Homolog1 2
Oncogene RRAS1 2
p232 3
Ras-Related Protein R-Ras2

External Ids:    HGNC: 104471   Entrez Gene: 62372   Ensembl: ENSG000001264587   OMIM: 1650905   UniProtKB: P103013   

Export aliases for RRAS gene to outside databases

Previous GC identifers: GC19M050796 GC19M050506 GC19M054814 GC19M054830 GC19M046515


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RRAS Gene: 
RRAS (related RAS viral (r-ras) oncogene homolog) is a protein-coding gene. Diseases associated with RRAS include tick infestation, and noonan syndrome, and among its related super-pathways are Regulation of actin cytoskeleton and MAPK Cascade. GO annotations related to this gene include GDP binding and GTP binding. An important paralog of this gene is REM2.

UniProtKB/Swiss-Prot: RRAS_HUMAN, P10301
Function: Regulates the organization of the actin cytoskeleton

Gene Wiki entry for RRAS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RRAS gene promoter:
         COUP-TF1   STAT1   p53   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRRAS promoter sequence
   Search SABiosciences Chromatin IP Primers for RRAS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RRAS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

RRAS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RRAS gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M050138:  view genomic region     (about GC identifiers)

Start:
50,138,549 bp from pter      End:
50,143,458 bp from pter
Size:
4,910 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RRAS_HUMAN, P10301 (See protein sequence)
Recommended Name: Ras-related protein R-Ras precursor  
Size: 218 amino acids; 23480 Da
Subunit: Interacts with PLCE1. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity)
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Inner surface of plasma
membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS)
1 PDB 3D structure from and Proteopedia for RRAS:
2FN4 (3D)    
Secondary accessions: Q6FH12

Explore the universe of human proteins at neXtProt for RRAS: NX_P10301

Explore proteomics data for RRAS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P10301

  • RRAS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RRAS Protein Expression
    REFSEQ proteins: NP_006261.1  
    ENSEMBL proteins: 
     ENSP00000246792  
    Reactome Protein details: P10301
    Human Recombinant Protein Products for RRAS: 
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    OriGene Protein Over-expression Lysate for RRAS
    OriGene MassSpec for RRAS 
    OriGene Custom Protein Services for RRAS
    GenScript Custom Purified and Recombinant Proteins Services for RRAS
    Novus Biologicals RRAS Proteins
    Novus Biologicals RRAS Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for RRAS
    Cloud-Clone Corp. Proteins for RRAS 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----

    RRAS for ontologies           About GeneDecksing



    RRAS Antibody Products: 
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    ThermoFisher Antibodies for RRAS
    LSBio Antibodies in human, mouse, rat for RRAS 

    Assay Products for RRAS: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for RRAS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RRAS 
    Cloud-Clone Corp. CLIAs for RRAS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry P10301

    ProtoNet protein and cluster: P10301

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase


    UniProtKB/Swiss-Prot: RRAS_HUMAN, P10301
    Similarity: Belongs to the small GTPase superfamily. Ras family


    RRAS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RRAS_HUMAN, P10301
    Function: Regulates the organization of the actin cytoskeleton

         Genatlas biochemistry entry for RRAS:
    Ras oncogene homolog,related,tightly linked to a full size LTR of human endogenous retroviruses HERV-K,regulating
    the binding of integrins to their ligands,outside the cells,phosphorylated by EPHR1 and no longer supporting
    integrin activity

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA16773572
    GO:0005515protein binding IPI17474147
    GO:0005525GTP binding IEA--
    GO:0019003GDP binding IDA16773572
         
    RRAS for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RRAS:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rras):
     cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system  tumorigenesis 

    RRAS for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RRAS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RRAS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RRAS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RRAS 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RRAS
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate RRAS (see all 11):
    hsa-miR-34c-5p hsa-miR-449b hsa-miR-3120-3p hsa-miR-128 hsa-miR-3681* hsa-miR-449a hsa-miR-1912 hsa-miR-34a
    SwitchGear 3'UTR luciferase reporter plasmidRRAS 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RRAS (see all 7)
    OriGene ORF clones in mouse, rat for RRAS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RRAS (NM_006270)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RRAS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRAS
    Sirion Biotech Customized lentivirus for stable overexpression of RRAS 
                         Customized lentivirus expression plasmids for stable overexpression of RRAS 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRAS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RRAS About   (see all 61)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    2G-protein signaling Ras family GTPases in kinase cascades (scheme)
    G-protein signaling Ras family GTPases in kinase cascades (scheme)0.44
    MAPK Cascade0.44
    3ErbB4 Pathway
    ErbB4 Pathway0.59
    LPS Stimulated MAPK Signaling0.47
    ErbB Family Pathway0.59
    UVC-Induced MAPK Signaling0.44
    Prolactin Signaling0.54
    TREM1 Pathway0.43
    Thrombopoietin Pathway0.51
    HMGB1 Pathway0.36
    4Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    ERK5 Signaling0.61
    Rac1 Pathway0.65
    eIF2 Pathway0.60
    Glioma Invasiveness0.64
    Rap1 Pathway0.57
    5GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    Estrogen Pathway0.55
    GPCR Pathway0.62
    P2Y Receptor Signaling0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for RRAS
        Development G-Proteins mediated regulation MARK-ERK signaling
    G-protein signaling G-Protein alpha-12 signaling pathway
    G-protein signaling Ras family GTPases in kinase cascades (scheme)

    5/109 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RRAS (see all 109)
        Fc-GammaR Pathway
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    CDK5 Pathway

    1 Cell Signaling Technology (CST) Pathway for RRAS
        Cytoskeletal Signaling

    3 GeneGo (Thomson Reuters) Pathways for RRAS
        G-protein signaling Ras family GTPases in kinase cascades (scheme)
    Development G-Proteins mediated regulation MARK-ERK signaling
    G-protein signaling G-Protein alpha-12 signaling pathway

    5/6 BioSystems Pathways for RRAS (see all 6)
        G Protein Signaling Pathways
    Integrated Breast Cancer Pathway
    Regulation of Actin Cytoskeleton
    MAPK Cascade
    EPHB forward signaling

    5/12        Reactome Pathways for RRAS (see all 12)
        Developmental Biology
    Transmission across Chemical Synapses
    Post NMDA receptor activation events
    Neuronal System
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell

    3 PharmGKB Pathways for RRAS
        Bisphosphonate Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Vemurafenib Pathway, Pharmacodynamics

    5         Kegg Pathways  (Kegg details for RRAS):
        MAPK signaling pathway
    Tight junction
    Regulation of actin cytoskeleton
    HTLV-I infection
    Proteoglycans in cancer


    RRAS for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RRAS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/74 Interacting proteins for RRAS (P103011, 2, 3 ENSP000002467924) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062412, 3, ENSP000003576564MINT-8111487 I2D: score=3 STRING: ENSP00000357656
    PIK3R1P279862, 3, ENSP000002743354MINT-8112207 I2D: score=3 STRING: ENSP00000274335
    PLCG1P191742, 3, ENSP000002440074MINT-8112735 I2D: score=3 STRING: ENSP00000244007
    ENSG00000206282O152113I2D: score=1 
    ENSG00000224841O152113I2D: score=1 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction ----

    RRAS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RRAS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RRAS

    10/11 Novoseek inferred chemical compound relationships for RRAS gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 62 8 9228027 (1), 7744959 (1), 10835426 (1), 16754664 (1) (see all 6)
    gtp 53.8 15 18784646 (3), 16522685 (2), 10671570 (2), 18270166 (1) (see all 8)
    phosphatidylinositol 50 7 12805072 (1), 10454580 (1), 10352023 (1), 10801791 (1) (see all 5)
    tyrosine 18.4 4 10570155 (2), 11682467 (1)
    proline 10.4 6 10671570 (5)
    tamoxifen 10 1 12386818 (1)
    threonine 4.33 1 8999998 (1)
    glycogen 4.01 2 17107957 (1), 16799460 (1)
    lipid 0 3 8999998 (1), 14623256 (1)
    estrogen 0 8 12386818 (4), 16914723 (3)

    Search CenterWatch for drugs/clinical trials and news about RRAS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RRAS gene: 
    NM_006270.3  

    Unigene Cluster for RRAS:

    Related RAS viral (r-ras) oncogene homolog
    Hs.515536  [show with all ESTs]
    Unigene Representative Sequence: BF965156
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000246792(uc002pop.1) ENST00000601532
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate RRAS (see all 11):
    hsa-miR-34c-5p hsa-miR-449b hsa-miR-3120-3p hsa-miR-128 hsa-miR-3681* hsa-miR-449a hsa-miR-1912 hsa-miR-34a
    SwitchGear 3'UTR luciferase reporter plasmidRRAS 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RRAS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRAS
    Sirion Biotech Customized lentivirus for stable overexpression of RRAS 
                         Customized lentivirus expression plasmids for stable overexpression of RRAS 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RRAS

    Additional mRNA sequence: 

    AF493920.1 BC016286.1 BC016318.1 BT006805.1 CR541944.1 CR541967.1 

    8 DOTS entries:

    DT.413325  DT.92429822  DT.121505275  DT.95191234  DT.100740241  DT.121505267  DT.95191264  DT.121624267 

    24/165 AceView cDNA sequences (see all 165):

    AI368184 AA315712 AI969219 AI828629 AI648524 CR626325 AA640176 BX357198 
    AI675908 BT006805 AW069039 BF591022 AI804197 AI201108 BC016286 BC016318 
    AI658480 BF591029 AI815073 BQ227915 AI480089 BU624215 W51840 AI399744 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RRAS    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
    SP1:                                    
    SP2:                                    


    ECgene alternative splicing isoforms for RRAS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RRAS expression in normal human tissues (normalized intensities)      RRAS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGTGCTGGCC
    RRAS Expression
    About this image


    RRAS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Endothelium (Cardiovascular System)
             blood outgrowth endothelial cell   
     
     Blood (Cardiovascular System)
             blood outgrowth endothelial cell   
     
     Eye (Sensory Organs)
             optic nerve head astrocytes   
     
     Brain (Nervous System)
             optic nerve head astrocytes   

    See RRAS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RRAS

    SOURCE GeneReport for Unigene cluster: Hs.515536
        SABiosciences Expression via Pathway-Focused PCR Arrays including RRAS: 
              Insulin Signaling Pathway in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RRAS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRAS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RRAS gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rras1 , 5 Harvey rat sarcoma oncogene, subgroup R1, 5 88.23(n)1
    94.5(a)1
      7 (29.08 cM)5
    201301  NM_009101.21  NP_033127.11 
     450179785 
    lizard
    (Anolis carolinensis)
    Reptilia RRAS6
    related RAS viral (r-ras) oncogene homolog
    69(a)
    1 ↔ 1
    6(80559594-80572708)
    zebrafish
    (Danio rerio)
    Actinopterygii wufb23a022 Transcribed sequence with weak similarity to protein more 77.54(n)    57081410 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ras64B3 RAS small monomeric GTPase 68(a)   64A8   --
    worm
    (Caenorhabditis elegans)
    Secernentea ras-13   -- 64(a)
    (best of 3)
      II(12345165-12347292)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RAS16
    RAS26
    GTPase involved in G-protein signaling in the aden...
    GTP-binding protein that regulates the nitrogen st...
    35(a)
    31(a)
    many ↔ many
    many ↔ many
    XV(515244-516173)
    XIV(439602-440570)


    ENSEMBL Gene Tree for RRAS (if available)
    TreeFam Gene Tree for RRAS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RRAS gene
    REM22  REM12  GEM2  RRAS22  MRAS2  ERAS2  RRAD2  
    18/69 SIMAP similar genes for RRAS using alignment to 1 protein entry:     RRAS_HUMAN(see all similar genes):
    RRAS2    c-bas/has    MRAS    RALA    RALB    RAP1B
    RAP2A    DKFZp547A0616    HRAS    RHEB    NRAS    DIRAS1
    KRAS    RIT2    RIT1    RAB17    RAP1A    RASL12

    RRAS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/132 SNPs in RRAS are shown (see all 132)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1860829541,2
    --50138140(+) ACCACC/TGCACT 1 -- int10--------
    rs346478241,2
    C,F--50138143(+) ACTGCA/CCTCTA 1 -- int18Minor allele frequency- C:0.19NA CSA EA 251
    rs604830511,2
    C,F--50138204(+) ACACAC/AAAACA 1 -- int12Minor allele frequency- A:0.20WA 120
    rs665252531,2
    C--50138204(-) CTGTT-/TGTGTGT 1 -- int11Minor allele frequency- TG:0.00NA 2
    rs1898814521,2
    --50138313(+) TAGATG/TCGAGG 1 -- int10--------
    rs1831887271,2
    --50138500(+) TACAGA/GAGTGA 1 -- int10--------
    rs1878717031,2
    --50138511(+) GCCACA/GGTGCC 1 -- int10--------
    rs1471778341,2
    --50138553(+) CTGACA/GTTGGC 1 -- ut310--------
    rs1170282151,2
    C,F--50138596(+) ATATAC/TAGCAG 1 -- ut311Minor allele frequency- T:0.02EA 120
    rs1925983001,2
    C--50138608(+) GACCCA/GGAGCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RRAS (50138549 - 50143458 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for RRAS:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv912269CNV Loss21882294
    nsv912266CNV Loss21882294
    dgv3972n71CNV Loss21882294
    nsv828578CNV Loss20364138
    nsv470150CNV Gain18288195
    nsv833864CNV Gain17160897
    nsv817854CNV Gain17921354
    nsv9739CNV Gain+Loss18304495
    nsv833865CNV Gain+Loss17160897
    nsv469715CNV Complex16826518

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 165090    OMIM disorders: --

    13 diseases for RRAS:    About MalaCards
    tick infestation    noonan syndrome    biliary atresia    glomerulonephritis
    glioblastoma    breast cancer    sarcoma    cervicitis
    melanoma    prostate cancer    prostatitis    endotheliitis
    neuronitis


    RRAS for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for RRAS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 2.95 1 12548599 (1)
    breast cancer 0 8 12386818 (3), 16914723 (2)


    Export disorders for RRAS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RRAS gene, integrated from 9 sources (see all 100):
    (articles sorted by number of sources associating them with RRAS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes. (PubMed id 3098437)1, 2, 3 Lowe D.G....Goeddel D.V. (1987)
    2. The small GTPase R-Ras regulates organization of actin and drives membrane protrusions through the activity of PLCepsilon. (PubMed id 16537651)1, 2 Ada-Nguema A.S.... Keely P.J. (2006)
    3. Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype. (PubMed id 16773572)1, 2 Carta C.... Tartaglia M. (2006)
    4. Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. (PubMed id 15242332)1, 2 Aboulaich N.... Vener A.V. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras. (PubMed id 10671570)1, 9 Wang B....Ruoslahti E. (2000)
    7. R-Ras controls membrane protrusion and cell migration through the spatial regulation of Rac and Rho. (PubMed id 15525681)1, 9 Wozniak M.A....Keely P.J. (2005)
    8. Cyclic AMP-dependent and Epac-mediated activation of R-Ras by G protein-coupled receptors leads to phospholipase D stimulation. (PubMed id 16754664)1, 9 Lopez De Jesus M....Schmidt M. (2006)
    9. R-Ras promotes focal adhesion formation through focal adhesion kinase and p130(Cas) by a novel mechanism that differs from integrins. (PubMed id 12529399)1, 9 Kwong L....Keely P.J. (2003)
    10. The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function. (PubMed id 11042683)1, 9 Oertli B....Hughes P.E. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6237 HGNC: 10447 AceView: RRAS Ensembl:ENSG00000126458 euGenes: HUgn6237
    ECgene: RRAS Kegg: 6237 H-InvDB: RRAS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RRAS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RRAS Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RRAS gene:
    Search GeneIP for patents involving RRAS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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