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Aliases for RRAS Gene

Aliases for RRAS Gene

  • Related RAS Viral (R-Ras) Oncogene Homolog 2 3
  • Oncogene RRAS 2 3
  • P23 3 4
  • Ras Family Small GTP Binding Protein R-Ras 3

External Ids for RRAS Gene

Previous GeneCards Identifiers for RRAS Gene

  • GC19M050796
  • GC19M050506
  • GC19M054814
  • GC19M054830
  • GC19M050138
  • GC19M046515

Summaries for RRAS Gene

Entrez Gene Summary for RRAS Gene

  • The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015]

GeneCards Summary for RRAS Gene

RRAS (Related RAS Viral (R-Ras) Oncogene Homolog) is a Protein Coding gene. Diseases associated with RRAS include tick infestation and gemistocytic astrocytoma. Among its related pathways are MAPK signaling pathway and GPCR Pathway. GO annotations related to this gene include GTP binding and protein complex binding. An important paralog of this gene is HRAS.

UniProtKB/Swiss-Prot for RRAS Gene

  • Regulates the organization of the actin cytoskeleton.

Gene Wiki entry for RRAS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRAS Gene

Genomics for RRAS Gene

Regulatory Elements for RRAS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RRAS Gene

Chromosome:
19
Start:
49,635,292 bp from pter
End:
49,640,201 bp from pter
Size:
4,910 bases
Orientation:
Minus strand

Genomic View for RRAS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RRAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRAS Gene

Proteins for RRAS Gene

  • Protein details for RRAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10301-RRAS_HUMAN
    Recommended name:
    Ras-related protein R-Ras
    Protein Accession:
    P10301
    Secondary Accessions:
    • Q6FH12

    Protein attributes for RRAS Gene

    Size:
    218 amino acids
    Molecular mass:
    23480 Da
    Quaternary structure:
    • Interacts with PLCE1. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity).

    Three dimensional structures from OCA and Proteopedia for RRAS Gene

neXtProt entry for RRAS Gene

Proteomics data for RRAS Gene at MOPED

Post-translational modifications for RRAS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RRAS Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RRAS (RRas)

No data available for DME Specific Peptides for RRAS Gene

Domains & Families for RRAS Gene

Gene Families for RRAS Gene

Suggested Antigen Peptide Sequences for RRAS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10301

UniProtKB/Swiss-Prot:

RRAS_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RRAS: view

Function for RRAS Gene

Molecular function for RRAS Gene

GENATLAS Biochemistry:
Ras oncogene homolog,related,tightly linked to a full size LTR of human endogenous retroviruses HERV-K,regulating the binding of integrins to their ligands,outside the cells,phosphorylated by EPHR1 and no longer supporting integrin activity
UniProtKB/Swiss-Prot Function:
Regulates the organization of the actin cytoskeleton.

Gene Ontology (GO) - Molecular Function for RRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IMP 24705357
GO:0005515 protein binding IPI 17474147
GO:0005525 GTP binding IEA --
GO:0019003 GDP binding IMP 24705357
GO:0032403 protein complex binding IDA 23209302
genes like me logo Genes that share ontologies with RRAS: view
genes like me logo Genes that share phenotypes with RRAS: view

Animal Model Products

miRNA for RRAS Gene

miRTarBase miRNAs that target RRAS

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RRAS

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RRAS Gene

Localization for RRAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRAS Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RRAS Gene COMPARTMENTS Subcellular localization image for RRAS gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS 3098437
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with RRAS: view

Pathways & Interactions for RRAS Gene

genes like me logo Genes that share pathways with RRAS: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for RRAS Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for RRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002521 leukocyte differentiation IMP 24705357
GO:0006886 intracellular protein transport --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction --
genes like me logo Genes that share ontologies with RRAS: view

Drugs & Compounds for RRAS Gene

(6) Drugs for RRAS Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tamoxifen Approved Pharma Antagonist ER antagonist, Anti-Estrogens 341
estrogen Pharma 0
proline Nutra 20
serine Nutra 420
threonine Nutra 16

(5) Additional Compounds for RRAS Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
gdp
Glycogen
  • Animal starch
  • Glycogen
  • Liver starch
  • Lyoglycogen
  • Phytoglycogen
9005-79-2
gtp
Partial agonist, Agonist
LIPID
Phosphatidylinositol
genes like me logo Genes that share compounds with RRAS: view

Transcripts for RRAS Gene

mRNA/cDNA for RRAS Gene

Unigene Clusters for RRAS Gene

Related RAS viral (r-ras) oncogene homolog:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RRAS

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RRAS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2:

Relevant External Links for RRAS Gene

GeneLoc Exon Structure for
RRAS
ECgene alternative splicing isoforms for
RRAS

Expression for RRAS Gene

mRNA expression in normal human tissues for RRAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RRAS Gene

This gene is overexpressed in Prostate (10.0) and Urinary Bladder (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RRAS Gene



SOURCE GeneReport for Unigene cluster for RRAS Gene Hs.515536

genes like me logo Genes that share expression patterns with RRAS: view

Protein tissue co-expression partners for RRAS Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RRAS Gene

Orthologs for RRAS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RRAS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RRAS 35
  • 90.67 (n)
  • 96.79 (a)
RRAS 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RRAS 35
  • 91.9 (n)
  • 97.71 (a)
RRAS 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rras 35
  • 88.23 (n)
  • 94.5 (a)
Rras 16
Rras 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RRAS 35
  • 99.54 (n)
  • 99.54 (a)
RRAS 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rras 35
  • 88.23 (n)
  • 92.66 (a)
oppossum
(Monodelphis domestica)
Mammalia RRAS 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RRAS 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rras 35
  • 67.89 (n)
  • 74.87 (a)
zebrafish
(Danio rerio)
Actinopterygii rras 35
  • 67.54 (n)
  • 71.73 (a)
wufb23a02 35
rras 36
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ras64B 37
  • 68 (a)
Ras64B 36
  • 64 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C08F8.7 37
  • 46 (a)
ras-1 37
  • 64 (a)
ras-2 37
  • 51 (a)
ras-1 36
  • 56 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAS1 36
  • 35 (a)
ManyToMany
RAS2 36
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
OneToMany
Species with no ortholog for RRAS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRAS Gene

ENSEMBL:
Gene Tree for RRAS (if available)
TreeFam:
Gene Tree for RRAS (if available)

Paralogs for RRAS Gene

Paralogs for RRAS Gene

genes like me logo Genes that share paralogs with RRAS: view

Variants for RRAS Gene

Sequence variations from dbSNP and Humsavar for RRAS Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs14816 -- 49,635,552(+) TTGTG(A/G)TGGTT utr-variant-3-prime
rs731861 -- 49,635,862(-) CCCCC(C/G)TACCC intron-variant
rs1368463 -- 49,636,952(-) CCCAC(A/G/T)ATGGC intron-variant
rs1368464 -- 49,636,811(-) GGGTT(A/G)CTGGT intron-variant
rs1865076 -- 49,636,989(-) CTGAG(G/T)GCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RRAS Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833864 CNV Gain 17160897
nsv828578 CNV Loss 20364138
nsv469715 CNV Complex 16826518
nsv833865 CNV Gain+Loss 17160897
nsv912266 CNV Loss 21882294
dgv3972n71 CNV Loss 21882294
nsv912269 CNV Loss 21882294
nsv817854 CNV Gain 17921354
nsv470150 CNV Gain 18288195

Variation tolerance for RRAS Gene

Residual Variation Intolerance Score: 50.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRAS Gene

HapMap Linkage Disequilibrium report
RRAS
Human Gene Mutation Database (HGMD)
RRAS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRAS Gene

Disorders for RRAS Gene

MalaCards: The human disease database

(3) MalaCards diseases for RRAS Gene - From: DISEASES

Disorder Aliases PubMed IDs
tick infestation
  • tick infestations
gemistocytic astrocytoma
  • gemistocytic astrocytic tumor
eastern equine encephalitis
  • neuroinvasive eastern equine encephalitis virus infection
- elite association
Search RRAS in MalaCards View complete list of genes associated with diseases

Relevant External Links for RRAS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RRAS
genes like me logo Genes that share disorders with RRAS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RRAS Gene

Publications for RRAS Gene

  1. R-Ras regulates beta1-integrin trafficking via effects on membrane ruffling and endocytosis. (PMID: 20167113) Conklin M.W. … Keely P.J. (BMC Cell Biol. 2010) 23 67
  2. Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras. (PMID: 20385769) Sakurai A. … Gutkind J.S. (Mol. Cell. Biol. 2010) 23 67
  3. Structure and function of the intracellular region of the plexin-B1 transmembrane receptor. (PMID: 19843518) Tong Y. … Buck M. (J. Biol. Chem. 2009) 23 67
  4. C3G overexpression in glomerular epithelial cells during anti-GBM-induced glomerulonephritis. (PMID: 18784646) Rufanova V.A. … Sorokin A. (Kidney Int. 2009) 23 67
  5. Different requirement for Rnd GTPases of R-Ras GAP activity of Plexin-C1 and Plexin-D1. (PMID: 19136556) Uesugi K. … Negishi M. (J. Biol. Chem. 2009) 23 67

Products for RRAS Gene

Sources for RRAS Gene

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