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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RRAS Gene

protein-coding GIFtS: 62
GCID: GC19M050138

related RAS viral (r-ras) oncogene homolog

Explore 13 diseases affiliated with
RRAS via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Related RAS Viral (R-Ras) Oncogene Homolog¹ ²
P23¹
Oncogene RRAS²
Ras-Related Protein R-Ras²

External Ids:	HGNC: 10447¹	Entrez Gene: 6237²	Ensembl: ENSG00000126458⁷	OMIM: 165090⁵	UniProtKB: P10301³

Export aliases for RRAS gene to outside databases

Previous GC identifers: GC19M050796 GC19M050506 GC19M054814 GC19M054830 GC19M046515

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RRAS_HUMAN, P10301

Function: Regulates the organization of the actin cytoskeleton

Gene Wiki entry for RRAS

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RRAS gene promoter:
COUP-TF1 STAT1 p53 NF-kappaB1 NF-kappaB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RRAS promoter sequence

Search SABiosciences Chromatin IP Primers for RRAS

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RRAS

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3-qter Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.3-qter

RRAS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RRAS gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M050138: view genomic region (about GC identifiers)

Start:	50,138,552 bp from pter	End:	50,143,400 bp from pter
Size:	4,849 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RRAS_HUMAN, P10301 (See protein sequence)

Recommended Name: Ras-related protein R-Ras precursor

Size: 218 amino acids; 23480 Da

Subunit: Interacts with PLCE1. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity)

Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Inner surface of plasma

membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS)

1 PDB 3D structure from and Proteopedia for RRAS:

2FN4 (3D)

Secondary accessions: Q6FH12

Explore the universe of human proteins at neXtProt for RRAS: NX_P10301

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P10301

RRAS Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006261.1

ENSEMBL proteins:

ENSP00000246792

Reactome Protein details: P10301
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: RRAS OriGene Protein Over-expression Lysate: RRAS OriGene Custom Protein Services for RRAS
	GenScript Custom Purified and Recombinant Proteins Services for RRAS
	Novus Biologicals RRAS Proteins Novus Biologicals RRAS Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for RRAS
	Uscn Proteins for RRAS

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--

RRAS for ontologies About GeneDecksing

RRAS Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Cell Signaling Technology (CST) Antibodies for RRAS
	Browse OriGene Antibodies OriGene Custom Antibody Services for RRAS
	GenScript Custom Superior Antibodies Services for RRAS
	Novus Biologicals RRAS Antibodies
	Search for Antibodies for RRAS at Abcam
	Uscn Antibodies for RRAS
	Search ThermoFisher Antibodies for RRAS

Assay Products for RRAS:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RRAS
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RRAS

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RRAS for domains About GeneDecksing

3 InterPro domains/families:

IPR005225 Small_GTP-bd_dom

IPR001806 Small_GTPase

IPR020849 Small_GTPase_Ras

Graphical View of Domain Structure for InterPro Entry P10301

ProtoNet protein and cluster: P10301

2 Blocks protein families:

IPB001806 Transforming protein P21 RAS signature

IPB003577 Ras small GTPase

UniProtKB/Swiss-Prot: RRAS_HUMAN, P10301

Similarity: Belongs to the small GTPase superfamily. Ras family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RRAS_HUMAN, P10301

Function: Regulates the organization of the actin cytoskeleton

Genatlas biochemistry entry for RRAS:

Ras oncogene homolog,related,tightly linked to a full size LTR of human endogenous retroviruses HERV-K,regulating the

binding of integrins to their ligands,outside the cells,phosphorylated by EPHR1 and no longer supporting integrin

activity

miRNA Products:		OriGene 3'-UTR Clone: RRAS Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RRAS
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate RRAS (see all 11):
		hsa-miR-34c-5p hsa-miR-449b hsa-miR-3120-3p hsa-miR-128 hsa-miR-3681* hsa-miR-449a hsa-miR-1912 hsa-miR-34a

		SwitchGear 3'UTR luciferase reporter plasmid: RRAS 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RRAS (see all 7) OriGene shRNA RFP: RRAS OriGene siRNA: RRAS
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RRAS

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RRAS

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RRAS (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RRAS OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RRAS (NM_006270)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RRAS
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRAS

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RRAS
		Search LifeMap BioReagents cell lines for RRAS

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RRAS

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	IDA	16773572
GO:0005515	protein binding	IPI	17474147
GO:0005525	GTP binding	IEA	--
GO:0019003	GDP binding	IDA	16773572

RRAS for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for RRAS:

Decreased NANOG protein expres

Decreased OCT4 protein express

Decreased POU5F1-GFP protein e

Animal Models:
5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rras):

cardiovascular system

hematopoietic system

homeostasis/metabolism

immune system

tumorigenesis

RRAS for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/60 super-pathways (see all 60) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

ErbB4 Pathway

8/11 pathways (see all 11)
ErbB4 Pathway	1.00	Thrombopoietin Pathway	0.43
ErbB Family Pathway	0.59	LPS Stimulated MAPK Signaling	0.36
Prolactin Signaling	0.54	TREM1 Pathway	0.32
ErbB2-ErbB3 Heterodimers	0.47	HMGB1 Pathway	0.32

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Paxillin Interactions	0.53
Breast Cancer Regulation by Stathmin1	0.58	P2Y Receptor Signaling	0.38

CCR3 Pathway in Eosinophils

CCR3 Pathway in Eosinophils	1.00	CXCR4 Pathway	0.39
VEGF and S-1P Signaling	0.44	Alpha-Adrenergic Signaling	0.31
fMLP Pathway	0.43	Internalin Pathway	0.19

Apoptotic Pathways in Synovial Fibroblasts

PPAR Pathway	0.66	Rac1 Pathway	0.58
ERK5 Signaling	0.61	Glioma Invasiveness	0.54
eIF2 Pathway	0.60	Rap1 Pathway	0.42

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for RRAS

	Development G-Proteins mediated regulation MARK-ERK signaling
	G-protein signaling G-Protein alpha-12 signaling pathway
	G-protein signaling Ras family GTPases in kinase cascades (scheme)

5/109 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RRAS (see all 109)

	Fc-GammaR Pathway
	Molecular Mechanisms of Cancer
	eIF2 Pathway
	Intracellular Calcium Signaling
	CDK5 Pathway

1 Cell Signaling Technology (CST) Pathway for RRAS

Cytoskeletal Signaling

3 GeneGo (Thomson Reuters) Pathways for RRAS

	G-protein signaling Ras family GTPases in kinase cascades (scheme)
	Development G-Proteins mediated regulation MARK-ERK signaling
	G-protein signaling G-Protein alpha-12 signaling pathway

5/6 BioSystems Pathways for RRAS (see all 6)

	G Protein Signaling Pathways
	Integrated Breast Cancer Pathway
	MAPK Cascade
	Regulation of Actin Cytoskeleton
	EPHB forward signaling

5/12 Reactome Pathways for RRAS (see all 12)

	Developmental Biology
	Transmission across Chemical Synapses
	Post NMDA receptor activation events
	Neuronal System
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell

3 PharmGKB Pathways for RRAS

	Bisphosphonate Pathway, Pharmacodynamics
	EGFR Inhibitor Pathway, Pharmacodynamics
	Vemurafenib Pathway, Pharmacodynamics

3 Kegg Pathways (Kegg details for RRAS):

	MAPK signaling pathway
	Tight junction
	Regulation of actin cytoskeleton

RRAS for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RRAS

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/70 Interacting proteins for RRAS (P10301^{1, 2, 3} ENSP00000246792⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 70)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FYN	P06241²^,³, ENSP00000357656⁴	MINT-8111487 I2D: score=3 STRING: ENSP00000357656
PIK3R1	P27986²^,³, ENSP00000274335⁴	MINT-8112207 I2D: score=3 STRING: ENSP00000274335
PLCG1	P19174²^,³, ENSP00000244007⁴	MINT-8112735 I2D: score=3 STRING: ENSP00000244007
NCK1	P16333¹^,³, ENSP00000288986⁴	EBI-968703,EBI-3448658 I2D: score=5 STRING: ENSP00000288986
SRC	P12931²^,³, ENSP00000350941⁴	MINT-8113239 I2D: score=3 STRING: ENSP00000350941

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006184	GTP catabolic process	--	--
GO:0007265	Ras protein signal transduction	TAS	3098437
GO:0007268	synaptic transmission	TAS	--
GO:0007411	axon guidance	TAS	--
GO:0030336	negative regulation of cell migration	IEA	--

RRAS for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RRAS for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RRAS
10/11 Novoseek chemical compound relationships for RRAS gene (see all 11) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gdp	62	8	9228027 (1), 7744959 (1), 10835426 (1), 16754664 (1) (see all 6)
gtp	53.8	15	18784646 (3), 16522685 (2), 10671570 (2), 18270166 (1) (see all 8)
phosphatidylinositol	50	7	12805072 (1), 10454580 (1), 10352023 (1), 10801791 (1) (see all 5)
tyrosine	18.4	4	10570155 (2), 11682467 (1)
proline	10.4	6	10671570 (5)
tamoxifen	10	1	12386818 (1)
threonine	4.33	1	8999998 (1)
glycogen	4.01	2	17107957 (1), 16799460 (1)
lipid	0	3	8999998 (1), 14623256 (1)
estrogen	0	8	12386818 (4), 16914723 (3)

Search CenterWatch for drugs/clinical trials and news about RRAS

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RRAS gene:

NM_006270.3

Unigene Cluster for RRAS:

Related RAS viral (r-ras) oncogene homolog

Hs.515536 [show with all ESTs]

Unigene Representative Sequence: BF965156

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000246792(uc002pop.1)

miRNA Products:		OriGene 3'-UTR Clone: RRAS Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RRAS
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate RRAS (see all 11):
		hsa-miR-34c-5p hsa-miR-449b hsa-miR-3120-3p hsa-miR-128 hsa-miR-3681* hsa-miR-449a hsa-miR-1912 hsa-miR-34a

		SwitchGear 3'UTR luciferase reporter plasmid: RRAS 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RRAS (see all 7) OriGene shRNA RFP: RRAS OriGene siRNA: RRAS
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RRAS

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RRAS (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RRAS OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RRAS (NM_006270)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RRAS
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRAS

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RRAS Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RRAS
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RRAS
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RRAS

Additional cDNA sequence:

AF493920.1 BC016286.1 BC016318.1 BT006805.1 CR541944.1 CR541967.1

8 DOTS entries:

DT.413325 DT.92429822 DT.121505275 DT.95191234 DT.100740241 DT.121505267 DT.95191264 DT.121624267

24/165 AceView cDNA sequences (see all 165):

AI969219 BQ227915 BX357198 AI480089 AW069039 AI815073 AI368184 AI828629

BF591029 AA640176 CR626325 BC016286 AI804197 AI658480 BU624215 AA315712

BC016318 AI675908 W51840 AI648524 AI399744 BT006805 AI201108 BF591022

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for RRAS About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6
SP1:
SP2:

ECgene alternative splicing isoforms for RRAS

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RRAS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGTGCTGGCC

About this image

RRAS expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RRAS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RRAS

SOURCE GeneReport for Unigene cluster: Hs.515536

SABiosciences Expression via Pathway-Focused PCR Arrays including RRAS:

Insulin Signaling Pathway in human mouse rat

Nitric Oxide Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RRAS Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RRAS
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RRAS
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RRAS

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RRAS

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RRAS gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rras^{1 , 5}	Harvey rat sarcoma oncogene, subgroup R^{1, 5}	88.23(n)¹ 94.5(a)¹		7 (29.08 cM)⁵ 20130¹ NM_009101.2¹ NP_033127.1¹ 45017978⁵
lizard (Anolis carolinensis)	Reptilia	RRAS⁶	--	71(a)	1 ↔ 1	6(80559594-80572187)
zebrafish (Danio rerio)	Actinopterygii	wufb23a02²	Transcribed sequence with weak similarity to protein more	77.54(n)		57081410
fruit fly (Drosophila melanogaster)	Insecta	Ras64B³	RAS small monomeric GTPase	68(a)		64A8 --
worm (Caenorhabditis elegans)	Secernentea	ras-1³	--	64(a) (best of 3)		II(12345165-12347292) --

ENSEMBL Gene Tree for RRAS (if available)
TreeFam Gene Tree for RRAS (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RRAS gene

REM1² RALA² RIT2² RIT1² ERAS² RALB² NRAS² RRAD²

REM2² KRAS² GEM² RRAS2² HRAS² MRAS²

18/69 SIMAP similar genes for RRAS using alignment to 1 protein entry: RRAS_HUMAN(see all similar genes):

RRAS2 c-bas/has MRAS RALA RALB RAP1B

RAP2A DKFZp547A0616 HRAS RHEB NRAS DIRAS1

KRAS RIT2 RIT1 RAB17 RAP1A RASL12

RRAS for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186082954^1,2		--	50138140(+)	`ACCACC/TGCACT`	1	--	int¹		0	--	--	--	--
rs34647824^1,2	C,F,	--	50138143(+)	`ACTGCA/CCTCTA`	1	--	int¹		8		NA CSA EA	251
rs72243646^1,2	C,F,	--	50138183(+)	`GAAAA-/ACACACA`	1	--	int¹		2		NA CSA	4
rs66525253^1,2	C	--	50138184(-)	`CTGTT-/TGTGTGT`	1	--	int¹		1		NA	2
rs60483051^1,2	C,	--	50138204(+)	`ACACAC/AAAACA`	1	--	int¹		2		WA	120
rs189881452^1,2		--	50138313(+)	`TAGATG/TCGAGG`	1	--	int¹		0	--	--	--	--
rs183188727^1,2		--	50138500(+)	`TACAGA/GAGTGA`	1	--	int¹		0	--	--	--	--
rs187871703^1,2		--	50138511(+)	`GCCACA/GGTGCC`	1	--	int¹		0	--	--	--	--
rs147177834^1,2		--	50138553(+)	`CTGACA/GTTGGC`	1	--	ut3¹		0	--	--	--	--
rs117028215^1,2	C,F,	--	50138596(+)	`ATATAC/TAGCAG`	1	--	ut3¹		1		EA	120

HapMap Linkage Disequilibrium report for RRAS (50138552 - 50143400 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for RRAS
6 CNVs: 30912 2246 5112 9803 5113 32261

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RRAS for disorders           About GeneDecksing

OMIM gene information: 165090    OMIM disorders: --

13 diseases for RRAS:    About MalaCards

tick infestation biliary atresia estrogen resistance noonan syndrome

breast cancer glomerulonephritis prostate cancer sarcoma

cervicitis prostatitis melanoma neuronitis

glioblastoma

2 Novoseek disease relationships for RRAS gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	2.95	1	12548599 (1)
breast cancer	0	8	12386818 (3), 16914723 (2)

Export disorders for RRAS gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RRAS gene, integrated from 9 sources (see all 97):
(articles sorted by number of sources associating them with RRAS)

Utopia: connect your pdf to the dynamic
world of online information

Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes. (PubMed id 3098437)^{1, 2, 3} Lowe D.G....Goeddel D.V. (1987)
The small GTPase R-Ras regulates organization of actin and drives membrane protrusions through the activity of PLCepsilon. (PubMed id 16537651)^{1, 2} Ada-Nguema A.S.... Keely P.J. (2006)
Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype. (PubMed id 16773572)^{1, 2} Carta C.... Tartaglia M. (2006)
Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. (PubMed id 15242332)^{1, 2} Aboulaich N.... Vener A.V. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras. (PubMed id 10671570)^{1, 9} Wang B....Ruoslahti E. (2000)
R-Ras controls membrane protrusion and cell migration through the spatial regulation of Rac and Rho. (PubMed id 15525681)^{1, 9} Wozniak M.A....Keely P.J. (2005)
Cyclic AMP-dependent and Epac-mediated activation of R-Ras by G protein-coupled receptors leads to phospholipase D stimulation. (PubMed id 16754664)^{1, 9} Lopez De Jesus M....Schmidt M. (2006)
R-Ras promotes focal adhesion formation through focal adhesion kinase and p130(Cas) by a novel mechanism that differs from integrins. (PubMed id 12529399)^{1, 9} Kwong L....Keely P.J. (2003)
The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function. (PubMed id 11042683)^{1, 9} Oertli B....Hughes P.E. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6237	HGNC: 10447	AceView: RRAS	Ensembl:ENSG00000126458	euGenes: HUgn6237
ECgene: RRAS	Kegg: 6237	H-InvDB: RRAS

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RRAS	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RRAS	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RRAS gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RRAS gene:
Search GeneIP for patents involving RRAS

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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related RAS viral (r-ras) oncogene homolog

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