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Aliases for RRAS Gene

Aliases for RRAS Gene

  • Related RAS Viral (R-Ras) Oncogene Homolog 2 3
  • Oncogene RRAS 2 3
  • P23 3 4
  • Ras-Related Protein R-Ras 3

External Ids for RRAS Gene

Previous GeneCards Identifiers for RRAS Gene

  • GC19M050796
  • GC19M050506
  • GC19M054814
  • GC19M054830
  • GC19M050138
  • GC19M046515

Summaries for RRAS Gene

GeneCards Summary for RRAS Gene

RRAS (Related RAS Viral (R-Ras) Oncogene Homolog) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and GPCR Pathway. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is HRAS.

UniProtKB/Swiss-Prot for RRAS Gene

  • Regulates the organization of the actin cytoskeleton.

Gene Wiki entry for RRAS Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRAS Gene

Genomics for RRAS Gene

Regulatory Elements for RRAS Gene

Genomic Location for RRAS Gene

49,635,292 bp from pter
49,640,201 bp from pter
4,910 bases
Minus strand

Genomic View for RRAS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RRAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRAS Gene

Proteins for RRAS Gene

  • Protein details for RRAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein R-Ras
    Protein Accession:
    Secondary Accessions:
    • Q6FH12

    Protein attributes for RRAS Gene

    218 amino acids
    Molecular mass:
    23480 Da
    Quaternary structure:
    • Interacts with PLCE1. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity).

    Three dimensional structures from OCA and Proteopedia for RRAS Gene

neXtProt entry for RRAS Gene

Proteomics data for RRAS Gene at MOPED

Post-translational modifications for RRAS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RRAS Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RRAS Gene

Domains for RRAS Gene

Suggested Antigen Peptide Sequences for RRAS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P10301
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RRAS: view

No data available for Gene Families for RRAS Gene

Function for RRAS Gene

Molecular function for RRAS Gene

GENATLAS Biochemistry: Ras oncogene homolog,related,tightly linked to a full size LTR of human endogenous retroviruses HERV-K,regulating the binding of integrins to their ligands,outside the cells,phosphorylated by EPHR1 and no longer supporting integrin activity
UniProtKB/Swiss-Prot Function: Regulates the organization of the actin cytoskeleton.

Gene Ontology (GO) - Molecular Function for RRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IMP 24705357
GO:0005515 protein binding IPI 17474147
GO:0005525 GTP binding IEA --
GO:0019003 GDP binding IMP 24705357
GO:0032403 protein complex binding IDA 23209302
genes like me logo Genes that share ontologies with RRAS: view
genes like me logo Genes that share phenotypes with RRAS: view

miRNA for RRAS Gene

miRTarBase miRNAs that target RRAS

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RRAS Gene

Localization for RRAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRAS Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).

Subcellular locations from

Jensen Localization Image for RRAS Gene COMPARTMENTS Subcellular localization image for RRAS gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 3
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for RRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with RRAS: view

Pathways for RRAS Gene

genes like me logo Genes that share pathways with RRAS: view

Gene Ontology (GO) - Biological Process for RRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002521 leukocyte differentiation IMP 24705357
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RRAS: view

Compounds for RRAS Gene

(11) Novoseek inferred chemical compound relationships for RRAS Gene

Compound -log(P) Hits PubMed IDs
gdp 62 6
gtp 53.8 12
phosphatidylinositol 50 5
tyrosine 18.4 3
proline 10.4 5
genes like me logo Genes that share compounds with RRAS: view

Transcripts for RRAS Gene

mRNA/cDNA for RRAS Gene

Unigene Clusters for RRAS Gene

Related RAS viral (r-ras) oncogene homolog:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RRAS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6

Relevant External Links for RRAS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RRAS Gene

mRNA expression in normal human tissues for RRAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RRAS Gene

SOURCE GeneReport for Unigene cluster for RRAS Gene Hs.515536

genes like me logo Genes that share expressions with RRAS: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RRAS Gene

Orthologs for RRAS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RRAS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RRAS 35
  • 99.54 (n)
  • 99.54 (a)
  • 100 (a)
(Bos Taurus)
Mammalia RRAS 35
  • 90.67 (n)
  • 96.79 (a)
  • 97 (a)
(Canis familiaris)
Mammalia RRAS 35
  • 91.9 (n)
  • 97.71 (a)
  • 98 (a)
(Mus musculus)
Mammalia Rras 35
  • 88.23 (n)
  • 94.5 (a)
Rras 16
Rras 36
  • 94 (a)
(Monodelphis domestica)
Mammalia RRAS 36
  • 68 (a)
(Rattus norvegicus)
Mammalia Rras 35
  • 88.23 (n)
  • 92.66 (a)
(Anolis carolinensis)
Reptilia RRAS 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rras 35
  • 67.89 (n)
  • 74.87 (a)
(Danio rerio)
Actinopterygii rras 35
  • 67.54 (n)
  • 71.73 (a)
rras 36
  • 71 (a)
wufb23a02 35
fruit fly
(Drosophila melanogaster)
Insecta Ras64B 36
  • 64 (a)
Ras64B 37
  • 68 (a)
(Caenorhabditis elegans)
Secernentea ras-1 36
  • 56 (a)
C08F8.7 37
  • 46 (a)
ras-1 37
  • 64 (a)
ras-2 37
  • 51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAS1 36
  • 35 (a)
RAS2 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
Species with no ortholog for RRAS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRAS Gene

Gene Tree for RRAS (if available)
Gene Tree for RRAS (if available)

Paralogs for RRAS Gene

Paralogs for RRAS Gene

genes like me logo Genes that share paralogs with RRAS: view

Variants for RRAS Gene

Sequence variations from dbSNP and Humsavar for RRAS Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs14816 -- 49,635,552(+) TTGTG(A/G)TGGTT utr-variant-3-prime
rs731861 -- 49,635,862(-) CCCCC(C/G)TACCC intron-variant
rs1368463 -- 49,636,952(-) CCCAC(A/G)ATGGC intron-variant
rs1368464 -- 49,636,811(-) GGGTT(A/G)CTGGT intron-variant
rs1865076 -- 49,636,989(-) CTGAG(G/T)GCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RRAS Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833864 CNV Gain 17160897
nsv828578 CNV Loss 20364138
nsv469715 CNV Complex 16826518
nsv833865 CNV Gain+Loss 17160897
nsv912266 CNV Loss 21882294
dgv3972n71 CNV Loss 21882294
nsv912269 CNV Loss 21882294
nsv817854 CNV Gain 17921354
nsv470150 CNV Gain 18288195

Relevant External Links for RRAS Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRAS Gene

Disorders for RRAS Gene

(2) Novoseek inferred disease relationships for RRAS Gene

Disease -log(P) Hits PubMed IDs
tumors 2.95 1
breast cancer 0 5
genes like me logo Genes that share disorders with RRAS: view

No data available for UniProtKB/Swiss-Prot for RRAS Gene

Publications for RRAS Gene

  1. Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes. (PMID: 3098437) Lowe D.G. … Goeddel D.V. (Cell 1987) 2 3 4
  2. Structure and function of the intracellular region of the plexin-B1 transmembrane receptor. (PMID: 19843518) Tong Y. … Buck M. (J. Biol. Chem. 2009) 3 23
  3. Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras. (PMID: 20385769) Sakurai A. … Gutkind J.S. (Mol. Cell. Biol. 2010) 3 23
  4. Positive regulation of skeletal myogenesis by R-Ras. (PMID: 10713701) Suzuki J. … Koide H. (Oncogene 2000) 3 23
  5. Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3. (PMID: 10777492) Ohba Y. … Matsuda M. (J. Biol. Chem. 2000) 3 23

Products for RRAS Gene

  • Addgene plasmids for RRAS

Sources for RRAS Gene

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