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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RRAGD Gene

protein-coding GIFtS: 51
GCID: GC06M090131

Ras-related GTP binding D

Explore 2 diseases affiliated with
RRAGD via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ras-Related GTP Binding D¹ ²		Rag D Protein²
BA11D8.2.1¹		Ras-Related GTP-Binding Protein D²
RAGD² ⁵		RagD³
DKFZP761H171¹		Rag D³

External Ids:	HGNC: 19903¹	Entrez Gene: 58528²	Ensembl: ENSG00000025039⁷	OMIM: 608268⁵	UniProtKB: Q9NQL2³

Export aliases for RRAGD gene to outside databases

Previous GC identifers: GC06M090024 GC06M090070 GC06M090073 GC06M087291

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RRAGD:

RRAGD is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as

molecular switches in numerous cell processes and signaling pathways.(supplied by OMIM, Apr 2004)

UniProtKB/Swiss-Prot: RRAGD_HUMAN, Q9NQL2

Function: Has guanine nucleotide-binding activity but lacks intrinsic GTPase activity. Probably required for the amino

acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a

crucial step in the activation of the TOR signaling cascade by amino acids

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007299.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RRAGD gene promoter:
COUP-TF1 AP-1 ATF-2 COUP HNF-4alpha2 HNF-4alpha1 PPAR-gamma1 COUP-TF c-Jun PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RRAGD promoter sequence

Search SABiosciences Chromatin IP Primers for RRAGD

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RRAGD

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q15-q16 Ensembl cytogenetic band: 6q15 HGNC cytogenetic band: 6q15-q16

RRAGD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RRAGD gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M090131: view genomic region (about GC identifiers)

Start:	90,074,335 bp from pter	End:	90,121,995 bp from pter
Size:	47,661 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RRAGD_HUMAN, Q9NQL2 (See protein sequence)

Recommended Name: Ras-related GTP-binding protein D

Size: 400 amino acids; 45588 Da

Subunit: Binds GTP. Forms a heterodimer with RRAGA in a sequence-independent manner and RRAGB. Heterodimerization

stabilizes PPAG proteins. In complex with RRAGB, interacts with RPTOR; this interaction is particularly efficient with

GTP-loaded RRAGB and GDP-loaded RRAGC. Interacts with NOL8

Subcellular location: Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm

and nucleus, depending on the bound nucleotide state of associated RRAGA

Sequence caution: Sequence=AAH03088.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

1 PDB 3D structure from and Proteopedia for RRAGD:

2Q3F (3D)

Secondary accessions: A8K184 Q7L8F9 Q9NPG0

Alternative splicing: 2 isoforms: Q9NQL2-1 Q9NQL2-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RRAGD: NX_Q9NQL2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NQL2

RRAGD Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_067067.1

ENSEMBL proteins:

ENSP00000358423 ENSP00000352131

Human Recombinant Protein Products:

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	GenScript Custom Purified and Recombinant Proteins Services for RRAGD
	Novus Biologicals RRAGD Proteins Novus Biologicals RRAGD Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RRAGD

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	11073942
GO:0005737	cytoplasm	IDA	11073942
GO:0005764	lysosome	IDA	--

RRAGD for ontologies About GeneDecksing

RRAGD Antibody Products:

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	Novus Biologicals RRAGD Antibodies
	Search for Antibodies for RRAGD at Abcam
	Uscn Antibodies for RRAGD
	ThermoFisher Antibody for RRAGD

Assay Products for RRAGD:

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	GenScript Custom Assay Services for RRAGD
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RRAGD

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RRAGD for domains About GeneDecksing

1 InterPro domain/family:

IPR006762 Gtr1_RagA

Graphical View of Domain Structure for InterPro Entry Q9NQL2

ProtoNet protein and cluster: Q9NQL2

UniProtKB/Swiss-Prot: RRAGD_HUMAN, Q9NQL2

Similarity: Belongs to the GTR/RAG GTP-binding protein family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RRAGD_HUMAN, Q9NQL2

Function: Has guanine nucleotide-binding activity but lacks intrinsic GTPase activity. Probably required for the amino

acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a

crucial step in the activation of the TOR signaling cascade by amino acids

miRNA Products:		OriGene 3'-UTR Clone: RRAGD Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RRAGD
		8/109 QIAGEN miScript miRNA Assays for microRNAs that regulate RRAGD (see all 109):
		hsa-miR-548j hsa-miR-579 hsa-miR-3678-3p hsa-miR-4254 hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-106a

		SwitchGear 3'UTR luciferase reporter plasmid: RRAGD 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RRAGD (see all 7) OriGene shRNA RFP: RRAGD OriGene siRNA: RRAGD
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RRAGD

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RRAGD

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RRAGD (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RRAGD OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RRAGD (NM_021244)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RRAGD
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRAGD

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RRAGD
		Search LifeMap BioReagents cell lines for RRAGD

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRAGD

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0005525	GTP binding	IEA	--
GO:0046982	protein heterodimerization activity	IPI	11073942

RRAGD for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Translational Control

Translational Control

1.00

mTOR signalling

TOR signaling

0.33

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for RRAGD

Translational Control

1 BioSystems Pathway for RRAGD

TOR signaling

RRAGD for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RRAGD

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

5/22 Interacting proteins for RRAGD (Q9NQL2^{1, 3} ENSP00000358423⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 22)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RRAGA	Q7L523¹^,³, ENSP00000369899⁴	EBI-992949,EBI-752376 I2D: score=6 STRING: ENSP00000369899
RRAGB	Q5VZM2¹^,³, ENSP00000262850⁴	EBI-992949,EBI-993049 I2D: score=5 STRING: ENSP00000262850
LAMTOR2	Q9Y2Q5³, ENSP00000357288⁴	I2D: score=1 STRING: ENSP00000357288
RPTOR	Q8N122³, ENSP00000307272⁴	I2D: score=1 STRING: ENSP00000307272
LAMTOR1	Q6IAA8³, ENSP00000278671⁴	I2D: score=1 STRING: ENSP00000278671

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0032008	positive regulation of TOR signaling cascade	NAS	--
GO:0034613	cellular protein localization	ISS	--
GO:0071230	cellular response to amino acid stimulus	ISS	--

RRAGD for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RRAGD

3 HMDB Compounds for RRAGD About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about RRAGD

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RRAGD gene:

NM_021244.4

Unigene Cluster for RRAGD:

Ras-related GTP binding D

Hs.31712 [show with all ESTs]

Unigene Representative Sequence: NM_021244

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000369415(uc003pnd.4 uc010kcc.3) ENST00000359203 ENST00000492783

miRNA Products:		OriGene 3'-UTR Clone: RRAGD Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RRAGD
		8/109 QIAGEN miScript miRNA Assays for microRNAs that regulate RRAGD (see all 109):
		hsa-miR-548j hsa-miR-579 hsa-miR-3678-3p hsa-miR-4254 hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-106a

		SwitchGear 3'UTR luciferase reporter plasmid: RRAGD 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RRAGD (see all 7) OriGene shRNA RFP: RRAGD OriGene siRNA: RRAGD
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RRAGD

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RRAGD (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RRAGD OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RRAGD (NM_021244)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RRAGD
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRAGD

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RRAGD Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RRAGD
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RRAGD
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RRAGD

Additional cDNA sequence:

AF272036.1 AJ420486.1 AK289799.1 BC003088.1

11 DOTS entries:

DT.211523 DT.100785132 DT.100035625 DT.100785129 DT.448599 DT.99990791 DT.95169508 DT.86854507

DT.121383930 DT.100785131 DT.121384065

24/209 AceView cDNA sequences (see all 209):

CB529917 AW235228 AW103510 CB045659 AI263348 AI393514 CD675913 AW589930

BM975804 CF455510 AW339728 AI968846 AI366343 BU738490 CR602554 CA438243

AW024980 AI499627 AI699917 AA453571 CB528334 CR614317 AA687624 BC003088

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RRAGD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGCACTAAA

About this image

RRAGD expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RRAGD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RRAGD

SOURCE GeneReport for Unigene cluster: Hs.31712

SABiosciences Expression via Pathway-Focused PCR Array including RRAGD:

mTOR Signaling in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RRAGD Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RRAGD
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RRAGD

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRAGD

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RRAGD gene from 5/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RRAGD¹	Ras-related GTP binding D	84.28(n) 95.5(a)		421814 XM_419838.3 XP_419838.3
lizard (Anolis carolinensis)	Reptilia	RRAGD⁶	--	95(a)	1 ↔ 1	1(174972674-174983733)
zebrafish (Danio rerio)	Actinopterygii	rragd¹	ras-related GTP binding D	74.78(n) 84.39(a)		570568 NM_001099424.1 NP_001092894.1
fruit fly (Drosophila melanogaster)	Insecta	RagC⁶	--	65(a)	1 → many	2R(4049184-4051018)
worm (Caenorhabditis elegans)	Secernentea	ragc-1⁶	--	47(a)	1 → many	IV(11603589-11604901)

ENSEMBL Gene Tree for RRAGD (if available)
TreeFam Gene Tree for RRAGD (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RRAGD gene

RRAGC²

1 SIMAP similar gene for RRAGD using alignment to 1 protein entry: RRAGD_HUMAN:

RRAGC

RRAGD for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147098824^1,2		--	90073842(+)	`GGTTGC/TCTCAT`	1	--	ds500¹		0	--	--	--	--
rs188931670^1,2		--	90073856(+)	`AAAAAC/TAGAAA`	1	--	ds500¹		0	--	--	--	--
rs74497720^1,2	C,F,	--	90073930(+)	`GCCTGC/TGGCAT`	1	--	ds500¹		1		WA	118
rs9344928^1,2	C,F,A,H,	--	90074027(+)	`TGATGG/TAAAAT`	1	--	ds500¹		13		NS EA WA	1938
rs138539259^1,2		--	90074077(+)	`AACAGA/GATTTC`	1	--	ds500¹		0	--	--	--	--
rs144049725^1,2		--	90074098(+)	`TATAAC/TATCTA`	1	--	ds500¹		0	--	--	--	--
rs181640137^1,2		--	90074242(+)	`CCACAC/GCAGCA`	1	--	ds500¹		0	--	--	--	--
rs183940669^1,2		--	90074258(+)	`TAATAC/TCTGAA`	1	--	ds500¹		0	--	--	--	--
rs189635152^1,2		--	90074452(+)	`CAATGA/GAACAG`	1	--	ut3¹		0	--	--	--	--
rs180753189^1,2		--	90074761(+)	`ATTCAA/GCTGTT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RRAGD (90074335 - 90121995 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RRAGD: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RRAGD

DNA2.0 Custom Variant and Variant Library Synthesis for RRAGD

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RRAGD for disorders           About GeneDecksing

OMIM gene information: 608268    OMIM disorders: --

2 diseases for RRAGD:    About MalaCards

omenn syndrome nevus

1 disease from the University of Copenhagen DISEASES database for RRAGD:

Omenn syndrome

Human Genome Epidemiology (HuGE) Navigator: RRAGD (2 documents)

Export disorders for RRAGD gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RRAGD gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with RRAGD)

Utopia: connect your pdf to the dynamic
world of online information

Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. (PubMed id 11073942)^{1, 2, 3} Sekiguchi T.... Nishimoto T. (2001)
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. (PubMed id 18497260)^{1, 2} Sancak Y....Sabatini D.M. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D. (PubMed id 14660641)^{1, 2} Sekiguchi T....Nishimoto T. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. (PubMed id 20381137)² Sancak Y....Sabatini D.M. (2010)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 58528	HGNC: 19903	AceView: RRAGD	Ensembl:ENSG00000025039	euGenes: HUgn58528
ECgene: RRAGD	H-InvDB: RRAGD

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RRAGD	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RRAGD gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RRAGD gene:
Search GeneIP for patents involving RRAGD

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Ras-related GTP binding D

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RRAGD Gene

Ras-related GTP binding D

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for RRAGD gene

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for RRAGD gene

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for RRAGD gene

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for RRAGD gene

Expression
for RRAGD gene

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for RRAGD gene

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for RRAGD gene

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for RRAGD gene

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for RRAGD gene

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for RRAGD gene

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for RRAGD gene

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