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Aliases for RRAGC Gene

Aliases for RRAGC Gene

  • Ras-Related GTP Binding C 2 3
  • RAGC 3 4 6
  • GTPase-Interacting Protein 2 3 4
  • TIB929 3 4
  • Ras-Related GTP-Binding Protein C 3
  • Rag C Protein 3
  • Rag C 4
  • GTR2 3

External Ids for RRAGC Gene

Previous GeneCards Identifiers for RRAGC Gene

  • GC01M038718
  • GC01M038717
  • GC01M038974
  • GC01M039076
  • GC01M039303
  • GC01M037423

Summaries for RRAGC Gene

Entrez Gene Summary for RRAGC Gene

  • This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

GeneCards Summary for RRAGC Gene

RRAGC (Ras-Related GTP Binding C) is a Protein Coding gene. Among its related pathways are Translational Control and Insulin receptor signalling cascade. GO annotations related to this gene include protein heterodimerization activity and GTPase activity. An important paralog of this gene is RRAGD.

UniProtKB/Swiss-Prot for RRAGC Gene

  • Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.

Gene Wiki entry for RRAGC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRAGC Gene

Genomics for RRAGC Gene

Regulatory Elements for RRAGC Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RRAGC Gene

Start:
38,838,197 bp from pter
End:
38,859,823 bp from pter
Size:
21,627 bases
Orientation:
Minus strand

Genomic View for RRAGC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RRAGC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRAGC Gene

Proteins for RRAGC Gene

  • Protein details for RRAGC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB90-RRAGC_HUMAN
    Recommended name:
    Ras-related GTP-binding protein C
    Protein Accession:
    Q9HB90
    Secondary Accessions:
    • Q9H202
    • Q9H8Q8

    Protein attributes for RRAGC Gene

    Size:
    399 amino acids
    Molecular mass:
    44224 Da
    Quaternary structure:
    • Forms a heterodimer with RRAGA, in a sequence-independent manner, and RRAGB. Heterodimerization stabilizes proteins of the heterodimer. In complex with RRAGA or RRAGB, interacts with RPTOR; this interaction is particularly efficient with GTP-loaded RRAGB and GDP-loaded RRAGC. Interacts with NOL8. Interacts with SH3BP4; the interaction with this negative regulator is most probably direct, preferentially occurs with the inactive GDP-bound form of RRAGB, is negatively regulated by amino acids and prevents interaction with RPTOR (PubMed:11073942, PubMed:14660641, PubMed:18497260, PubMed:22575674). The Rag heterodimer interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906).
    SequenceCaution:
    • Sequence=BAB14548.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RRAGC Gene

neXtProt entry for RRAGC Gene

Proteomics data for RRAGC Gene at MOPED

Post-translational modifications for RRAGC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RRAGC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RRAGC Gene

Domains for RRAGC Gene

Protein Domains for RRAGC Gene

Suggested Antigen Peptide Sequences for RRAGC Gene

Graphical View of Domain Structure for InterPro Entry

Q9HB90

UniProtKB/Swiss-Prot:

RRAGC_HUMAN :
  • Q9HB90
Family:
  • Belongs to the GTR/RAG GTP-binding protein family.
genes like me logo Genes that share domains with RRAGC: view

No data available for Gene Families for RRAGC Gene

Function for RRAGC Gene

Molecular function for RRAGC Gene

UniProtKB/Swiss-Prot Function: Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.

Gene Ontology (GO) - Molecular Function for RRAGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding NAS 11073942
GO:0003924 GTPase activity IDA 11073942
GO:0005515 protein binding IPI 11073942
GO:0005525 GTP binding IDA 11073942
GO:0019003 GDP binding IDA 11073942
genes like me logo Genes that share ontologies with RRAGC: view

Animal Model Products

CRISPR Products

miRNA for RRAGC Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RRAGC

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RRAGC Gene

Localization for RRAGC Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRAGC Gene

Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RRAGC Gene COMPARTMENTS Subcellular localization image for RRAGC gene
Compartment Confidence
lysosome 5
nucleus 5
vacuole 5
cytosol 3
endosome 1

Gene Ontology (GO) - Cellular Components for RRAGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 11073942
GO:0005764 lysosome IDA 20381137
GO:0034448 EGO complex IBA --
genes like me logo Genes that share ontologies with RRAGC: view

Pathways for RRAGC Gene

genes like me logo Genes that share pathways with RRAGC: view

Pathways by source for RRAGC Gene

1 Cell Signaling Technology pathway for RRAGC Gene
1 BioSystems pathway for RRAGC Gene
1 KEGG pathway for RRAGC Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RRAGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006351 transcription, DNA-templated NAS 11073942
GO:0006915 apoptotic process NAS 11073942
GO:0007264 small GTPase mediated signal transduction TAS 11073942
GO:0008380 RNA splicing NAS 11073942
genes like me logo Genes that share ontologies with RRAGC: view

Compounds for RRAGC Gene

(3) HMDB Compounds for RRAGC Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with RRAGC: view

Transcripts for RRAGC Gene

Unigene Clusters for RRAGC Gene

Ras-related GTP binding C:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RRAGC

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RRAGC Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b
SP1: -
SP2: - -
SP3: - -
SP4:

Relevant External Links for RRAGC Gene

GeneLoc Exon Structure for
RRAGC
ECgene alternative splicing isoforms for
RRAGC

Expression for RRAGC Gene

mRNA expression in normal human tissues for RRAGC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RRAGC Gene

SOURCE GeneReport for Unigene cluster for RRAGC Gene Hs.532461

genes like me logo Genes that share expressions with RRAGC: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RRAGC Gene

Orthologs for RRAGC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RRAGC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RRAGC 35
  • 99.3 (n)
  • 99.4 (a)
RRAGC 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RRAGC 35
  • 95.32 (n)
  • 99.25 (a)
RRAGC 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RRAGC 35
  • 96.24 (n)
  • 99.5 (a)
RRAGC 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rragc 35
  • 92.04 (n)
  • 96.48 (a)
Rragc 16
Rragc 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RRAGC 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RRAGC 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rragc 35
  • 90.79 (n)
  • 96.73 (a)
chicken
(Gallus gallus)
Aves RRAGC 35
  • 81.54 (n)
  • 91.98 (a)
RRAGC 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RRAGC 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7005 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rragc 35
  • 79.49 (n)
  • 89.01 (a)
Str.16064 35
zebrafish
(Danio rerio)
Actinopterygii rragca 35
  • 75.18 (n)
  • 87.11 (a)
rragca 36
  • 88 (a)
OneToMany
rragcb 36
  • 82 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007634 35
  • 65.35 (n)
  • 75.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta RagC 35
  • 67.41 (n)
  • 77.56 (a)
RagC 36
  • 66 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ragc-1 35
  • 54.51 (n)
  • 51.79 (a)
ragc-1 36
  • 49 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GTR2 36
  • 45 (a)
OneToMany
GTR2 38
bread mold
(Neurospora crassa)
Ascomycetes NCU00376 35
  • 54.47 (n)
  • 50.57 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gtr2 35
  • 63.38 (n)
  • 65.79 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9757 36
  • 65 (a)
OneToMany
Species with no ortholog for RRAGC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRAGC Gene

ENSEMBL:
Gene Tree for RRAGC (if available)
TreeFam:
Gene Tree for RRAGC (if available)

Paralogs for RRAGC Gene

Paralogs for RRAGC Gene

Selected SIMAP similar genes for RRAGC Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RRAGC: view

Variants for RRAGC Gene

Sequence variations from dbSNP and Humsavar for RRAGC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9694 -- 38,839,056(-) TTAAA(C/T)GCATT utr-variant-3-prime
rs11417 -- 38,838,292(+) TCACC(A/G)TGGTC utr-variant-3-prime
rs942842 -- 38,840,402(-) GCTGT(G/T)TAATA intron-variant
rs942843 -- 38,840,401(-) CTGTG(C/T)AATAA intron-variant
rs1925678 -- 38,859,391(-) CGCCC(A/G)GTCCC intron-variant

Relevant External Links for RRAGC Gene

HapMap Linkage Disequilibrium report
RRAGC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RRAGC Gene

Disorders for RRAGC Gene

No disorders were found for RRAGC Gene.

No data available for UniProtKB/Swiss-Prot for RRAGC Gene

Publications for RRAGC Gene

  1. Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. (PMID: 11073942) Sekiguchi T. … Nishimoto T. (J. Biol. Chem. 2001) 2 3 4
  2. Adenovirus immunoregulatory genes and their cellular targets. (PMID: 11145883) Horwitz M.S. (Virology 2001) 3 4
  3. A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D. (PMID: 14660641) Sekiguchi T. … Nishimoto T. (J. Biol. Chem. 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RRAGC Gene

  • Addgene plasmids for RRAGC

Sources for RRAGC Gene

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