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Aliases for RRAGC Gene

Aliases for RRAGC Gene

  • Ras Related GTP Binding C 2 3
  • Ras-Related GTP Binding C 2 3 5
  • GTPase-Interacting Protein 2 3 4
  • TIB929 3 4
  • RAGC 3 4
  • Rag C Protein 3
  • Rag C 4
  • GTR2 3

External Ids for RRAGC Gene

Previous GeneCards Identifiers for RRAGC Gene

  • GC01M038718
  • GC01M038717
  • GC01M038974
  • GC01M039076
  • GC01M039303
  • GC01M037423

Summaries for RRAGC Gene

Entrez Gene Summary for RRAGC Gene

  • This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

GeneCards Summary for RRAGC Gene

RRAGC (Ras Related GTP Binding C) is a Protein Coding gene. Among its related pathways are Translation Insulin regulation of translation and Translational Control. GO annotations related to this gene include protein heterodimerization activity and GTPase activity. An important paralog of this gene is RRAGD.

UniProtKB/Swiss-Prot for RRAGC Gene

  • Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.

Gene Wiki entry for RRAGC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRAGC Gene

Genomics for RRAGC Gene

Regulatory Elements for RRAGC Gene


Promoters for RRAGC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RRAGC on UCSC Golden Path with GeneCards custom track

Genomic Location for RRAGC Gene

Chromosome:
1
Start:
38,838,197 bp from pter
End:
38,859,823 bp from pter
Size:
21,627 bases
Orientation:
Minus strand

Genomic View for RRAGC Gene

Genes around RRAGC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRAGC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRAGC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRAGC Gene

Proteins for RRAGC Gene

  • Protein details for RRAGC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB90-RRAGC_HUMAN
    Recommended name:
    Ras-related GTP-binding protein C
    Protein Accession:
    Q9HB90
    Secondary Accessions:
    • Q9H202
    • Q9H8Q8

    Protein attributes for RRAGC Gene

    Size:
    399 amino acids
    Molecular mass:
    44224 Da
    Quaternary structure:
    • Forms a heterodimer with RRAGA, in a sequence-independent manner, and RRAGB. Heterodimerization stabilizes proteins of the heterodimer. In complex with RRAGA or RRAGB, interacts with RPTOR; this interaction is particularly efficient with GTP-loaded RRAGB and GDP-loaded RRAGC. Interacts with NOL8. Interacts with SH3BP4; the interaction with this negative regulator is most probably direct, preferentially occurs with the inactive GDP-bound form of RRAGB, is negatively regulated by amino acids and prevents interaction with RPTOR (PubMed:11073942, PubMed:14660641, PubMed:18497260, PubMed:22575674). The Rag heterodimer interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906).
    SequenceCaution:
    • Sequence=BAB14548.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RRAGC Gene

neXtProt entry for RRAGC Gene

Proteomics data for RRAGC Gene at MOPED

Post-translational modifications for RRAGC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RRAGC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RRAGC Gene

Domains & Families for RRAGC Gene

Protein Domains for RRAGC Gene

Suggested Antigen Peptide Sequences for RRAGC Gene

Graphical View of Domain Structure for InterPro Entry

Q9HB90

UniProtKB/Swiss-Prot:

RRAGC_HUMAN :
  • Belongs to the GTR/RAG GTP-binding protein family.
Family:
  • Belongs to the GTR/RAG GTP-binding protein family.
genes like me logo Genes that share domains with RRAGC: view

No data available for Gene Families for RRAGC Gene

Function for RRAGC Gene

Molecular function for RRAGC Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.

Gene Ontology (GO) - Molecular Function for RRAGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 11073942
GO:0019003 GDP binding IDA 11073942
genes like me logo Genes that share ontologies with RRAGC: view
genes like me logo Genes that share phenotypes with RRAGC: view

Animal Model Products

miRNA for RRAGC Gene

miRTarBase miRNAs that target RRAGC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRAGC Gene

Localization for RRAGC Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRAGC Gene

Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA (PubMed:11073942). {ECO:0000269 PubMed:11073942}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RRAGC Gene COMPARTMENTS Subcellular localization image for RRAGC gene
Compartment Confidence
cytosol 5
lysosome 5
nucleus 5
vacuole 5
endosome 2

Gene Ontology (GO) - Cellular Components for RRAGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1990131 Gtr1-Gtr2 GTPase complex IBA --
genes like me logo Genes that share ontologies with RRAGC: view

Pathways & Interactions for RRAGC Gene

genes like me logo Genes that share pathways with RRAGC: view

Pathways by source for RRAGC Gene

1 Cell Signaling Technology pathway for RRAGC Gene
1 BioSystems pathway for RRAGC Gene

SIGNOR curated interactions for RRAGC Gene

Activates:

Gene Ontology (GO) - Biological Process for RRAGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated NAS 11073942
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006915 apoptotic process NAS 11073942
GO:0007264 small GTPase mediated signal transduction TAS 11073942
GO:0010506 regulation of autophagy IBA --
genes like me logo Genes that share ontologies with RRAGC: view

Drugs & Compounds for RRAGC Gene

(3) Drugs for RRAGC Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RRAGC: view

Transcripts for RRAGC Gene

Unigene Clusters for RRAGC Gene

Ras-related GTP binding C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RRAGC Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b
SP1: -
SP2: - -
SP3: - -
SP4:

Relevant External Links for RRAGC Gene

GeneLoc Exon Structure for
RRAGC
ECgene alternative splicing isoforms for
RRAGC

Expression for RRAGC Gene

mRNA expression in normal human tissues for RRAGC Gene

Protein differential expression in normal tissues from HIPED for RRAGC Gene

This gene is overexpressed in Liver (24.6), Amniocyte (12.7), and Peripheral blood mononuclear cells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RRAGC Gene



SOURCE GeneReport for Unigene cluster for RRAGC Gene Hs.532461

genes like me logo Genes that share expression patterns with RRAGC: view

Protein tissue co-expression partners for RRAGC Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RRAGC Gene

Orthologs for RRAGC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RRAGC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RRAGC 35
  • 95.32 (n)
  • 99.25 (a)
RRAGC 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RRAGC 35
  • 96.24 (n)
  • 99.5 (a)
RRAGC 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rragc 35
  • 92.04 (n)
  • 96.48 (a)
Rragc 16
Rragc 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RRAGC 35
  • 99.3 (n)
  • 99.4 (a)
RRAGC 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rragc 35
  • 90.79 (n)
  • 96.73 (a)
oppossum
(Monodelphis domestica)
Mammalia RRAGC 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RRAGC 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves RRAGC 35
  • 81.54 (n)
  • 91.98 (a)
RRAGC 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RRAGC 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rragc 35
  • 79.49 (n)
  • 89.01 (a)
Str.16064 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7005 35
zebrafish
(Danio rerio)
Actinopterygii rragca 35
  • 75.18 (n)
  • 87.11 (a)
rragca 36
  • 88 (a)
OneToMany
rragcb 36
  • 82 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007634 35
  • 65.35 (n)
  • 75.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta RagC 35
  • 67.41 (n)
  • 77.56 (a)
RagC 36
  • 66 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ragc-1 35
  • 54.51 (n)
  • 51.79 (a)
ragc-1 36
  • 49 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GTR2 36
  • 45 (a)
OneToMany
GTR2 38
bread mold
(Neurospora crassa)
Ascomycetes NCU00376 35
  • 54.47 (n)
  • 50.57 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gtr2 35
  • 63.38 (n)
  • 65.79 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9757 36
  • 65 (a)
OneToMany
Species with no ortholog for RRAGC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRAGC Gene

ENSEMBL:
Gene Tree for RRAGC (if available)
TreeFam:
Gene Tree for RRAGC (if available)

Paralogs for RRAGC Gene

Paralogs for RRAGC Gene

(1) SIMAP similar genes for RRAGC Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RRAGC: view

Variants for RRAGC Gene

Sequence variations from dbSNP and Humsavar for RRAGC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs9694 -- 38,839,056(-) TTAAA(C/T)GCATT utr-variant-3-prime
rs942842 -- 38,840,402(-) GCTGT(G/T)TAATA intron-variant
rs942843 -- 38,840,401(-) CTGTG(C/T)AATAA intron-variant
rs2296457 -- 38,852,504(-) AAGCT(A/G)TGTTG intron-variant
rs2307925 -- 38,837,772(+) TTTAA(-/GAGT)GAGTC downstream-variant-500B

Variation tolerance for RRAGC Gene

Residual Variation Intolerance Score: 34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRAGC Gene

HapMap Linkage Disequilibrium report
RRAGC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RRAGC Gene

Disorders for RRAGC Gene

Relevant External Links for RRAGC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RRAGC

No disorders were found for RRAGC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRAGC Gene

Publications for RRAGC Gene

  1. Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. (PMID: 11073942) Sekiguchi T. … Nishimoto T. (J. Biol. Chem. 2001) 2 3 4 67
  2. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. (PMID: 25561175) Rebsamen M. … Superti-Furga G. (Nature 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging. (PMID: 24337580) Oshiro N. … Avruch J. (J. Biol. Chem. 2014) 3
  5. Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2. (PMID: 24529380) Demetriades C. … Teleman A.A. (Cell 2014) 3

Products for RRAGC Gene

Sources for RRAGC Gene

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