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Aliases for RRAGC Gene

Aliases for RRAGC Gene

  • Ras Related GTP Binding C 2 3 5
  • GTPase-Interacting Protein 2 3 4
  • TIB929 3 4
  • RAGC 3 4
  • Ras-Related GTP-Binding Protein C 3
  • Ras-Related GTP Binding C 2
  • Rag C Protein 3
  • Rag C 4
  • GTR2 3

External Ids for RRAGC Gene

Previous GeneCards Identifiers for RRAGC Gene

  • GC01M038718
  • GC01M038717
  • GC01M038974
  • GC01M039076
  • GC01M039303
  • GC01M037423

Summaries for RRAGC Gene

Entrez Gene Summary for RRAGC Gene

  • This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

GeneCards Summary for RRAGC Gene

RRAGC (Ras Related GTP Binding C) is a Protein Coding gene. Diseases associated with RRAGC include Birt-Hogg-Dube Syndrome and Dilated Cardiomyopathy. Among its related pathways are RET signaling and Translational Control. GO annotations related to this gene include protein heterodimerization activity and GTPase activity. An important paralog of this gene is RRAGD.

UniProtKB/Swiss-Prot for RRAGC Gene

  • Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.

Gene Wiki entry for RRAGC Gene

Additional gene information for RRAGC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRAGC Gene

Genomics for RRAGC Gene

Regulatory Elements for RRAGC Gene

Enhancers for RRAGC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H037988 1.2 ENCODE 20 +870.0 870036 2.4 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A ZFP41 SF3A3 C1orf109 INPP5B GNL2 FHL3 MYCBP FTH1P1 RSPO1 RRAGC YRDC
GH01H038984 1.5 Ensembl ENCODE dbSUPER 11.9 -126.4 -126396 2.5 PKNOX1 FOXA2 ZFP64 YY1 ZNF121 FOS TSHZ1 REST ZNF623 ZNF518A PPIE PPIEL TRIT1 SF3A3 NDUFS5 MYCBP RRAGC ENSG00000182109 LOC101929516 AKIRIN1
GH01H039573 1.3 ENCODE dbSUPER 10 -715.6 -715591 4.1 HDGF PKNOX1 ARNT ARID4B SIN3A YY1 ZNF766 ZNF207 ZNF143 REST OXCT2P1 PABPC4 PPIE OXCT2 RRAGC GC01M039568 GC01M039569 SNORA55
GH01H039700 1.1 Ensembl ENCODE 11.6 -841.6 -841559 1.9 HDAC1 HNRNPUL1 RB1 TBL1XR1 NFIB ZSCAN4 RAD21 ZNF766 GATA2 ZNF366 PPIE MYCBP RLF RRAGC NFYC ENSG00000182109 BMP8B LOC100128091
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RRAGC on UCSC Golden Path with GeneCards custom track

Promoters for RRAGC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for RRAGC Gene

Genomic Locations for RRAGC Gene
21,627 bases
Minus strand

Genomic View for RRAGC Gene

Genes around RRAGC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRAGC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRAGC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRAGC Gene

Proteins for RRAGC Gene

  • Protein details for RRAGC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related GTP-binding protein C
    Protein Accession:
    Secondary Accessions:
    • Q9H202
    • Q9H8Q8

    Protein attributes for RRAGC Gene

    399 amino acids
    Molecular mass:
    44224 Da
    Quaternary structure:
    • Forms a heterodimer with RRAGA, in a sequence-independent manner, and RRAGB. Heterodimerization stabilizes proteins of the heterodimer. In complex with RRAGA or RRAGB, interacts with RPTOR; this interaction is particularly efficient with GTP-loaded RRAGB and GDP-loaded RRAGC. Interacts with NOL8. Interacts with SH3BP4; the interaction with this negative regulator is most probably direct, preferentially occurs with the inactive GDP-bound form of RRAGB, is negatively regulated by amino acids and prevents interaction with RPTOR (PubMed:11073942, PubMed:14660641, PubMed:18497260, PubMed:22575674). The Rag heterodimer interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906). Interacts with SESN1, SESN2 AND SESN3 (PubMed:25259925).
    • Sequence=BAB14548.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RRAGC Gene

neXtProt entry for RRAGC Gene

Post-translational modifications for RRAGC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RRAGC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RRAGC Gene

Domains & Families for RRAGC Gene

Gene Families for RRAGC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RRAGC Gene

Suggested Antigen Peptide Sequences for RRAGC Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GTR/RAG GTP-binding protein family.
  • Belongs to the GTR/RAG GTP-binding protein family.
genes like me logo Genes that share domains with RRAGC: view

Function for RRAGC Gene

Molecular function for RRAGC Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.

Phenotypes From GWAS Catalog for RRAGC Gene

Gene Ontology (GO) - Molecular Function for RRAGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding NAS 11073942
GO:0003924 GTPase activity IDA 11073942
GO:0005515 protein binding IPI 11073942
GO:0005525 GTP binding IDA,IMP 22424946
GO:0019003 GDP binding IMP 22424946
genes like me logo Genes that share ontologies with RRAGC: view
genes like me logo Genes that share phenotypes with RRAGC: view

Animal Model Products

CRISPR Products

miRNA for RRAGC Gene

miRTarBase miRNAs that target RRAGC

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RRAGC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRAGC Gene

Localization for RRAGC Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRAGC Gene

Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA (PubMed:11073942). {ECO:0000269 PubMed:11073942}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRAGC gene
Compartment Confidence
nucleus 5
cytosol 5
lysosome 5
endosome 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RRAGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 11073942
GO:0005737 cytoplasm IEA,IDA 11073942
GO:0005764 lysosome IEA,IDA 20381137
GO:0005829 cytosol TAS --
GO:0034448 EGO complex IBA --
genes like me logo Genes that share ontologies with RRAGC: view

Pathways & Interactions for RRAGC Gene

genes like me logo Genes that share pathways with RRAGC: view

Pathways by source for RRAGC Gene

1 Cell Signaling Technology pathway for RRAGC Gene
1 BioSystems pathway for RRAGC Gene

SIGNOR curated interactions for RRAGC Gene


Gene Ontology (GO) - Biological Process for RRAGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated NAS 11073942
GO:0006915 apoptotic process NAS 11073942
GO:0007050 cell cycle arrest TAS --
GO:0007264 small GTPase mediated signal transduction TAS 11073942
GO:0008380 RNA splicing NAS 11073942
genes like me logo Genes that share ontologies with RRAGC: view

Drugs & Compounds for RRAGC Gene

(3) Drugs for RRAGC Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RRAGC: view

Transcripts for RRAGC Gene

Unigene Clusters for RRAGC Gene

Ras-related GTP binding C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RRAGC

Alternative Splicing Database (ASD) splice patterns (SP) for RRAGC Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b
SP1: -
SP2: - -
SP3: - -

Relevant External Links for RRAGC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RRAGC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RRAGC Gene

Protein differential expression in normal tissues from HIPED for RRAGC Gene

This gene is overexpressed in Liver (24.6), Amniocyte (12.7), and Peripheral blood mononuclear cells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RRAGC Gene

Protein tissue co-expression partners for RRAGC Gene

NURSA nuclear receptor signaling pathways regulating expression of RRAGC Gene:


SOURCE GeneReport for Unigene cluster for RRAGC Gene:


Evidence on tissue expression from TISSUES for RRAGC Gene

  • Liver(4.2)
  • Pancreas(3.2)
genes like me logo Genes that share expression patterns with RRAGC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RRAGC Gene

Orthologs for RRAGC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RRAGC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RRAGC 33 34
  • 99.3 (n)
(Canis familiaris)
Mammalia RRAGC 33 34
  • 96.24 (n)
(Bos Taurus)
Mammalia RRAGC 33 34
  • 95.32 (n)
(Mus musculus)
Mammalia Rragc 33 16 34
  • 92.04 (n)
(Monodelphis domestica)
Mammalia RRAGC 34
  • 92 (a)
(Rattus norvegicus)
Mammalia Rragc 33
  • 90.79 (n)
(Ornithorhynchus anatinus)
Mammalia RRAGC 34
  • 83 (a)
(Gallus gallus)
Aves RRAGC 33 34
  • 81.54 (n)
(Anolis carolinensis)
Reptilia RRAGC 34
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rragc 33
  • 79.49 (n)
Str.16064 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7005 33
(Danio rerio)
Actinopterygii rragcb 34
  • 82 (a)
rragca 33 34
  • 75.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta RagC 33 34
  • 67.41 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007634 33
  • 65.35 (n)
(Caenorhabditis elegans)
Secernentea ragc-1 33 34
  • 54.51 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GTR2 34 36
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9757 34
  • 65 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gtr2 33
  • 63.38 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00376 33
  • 54.47 (n)
Species where no ortholog for RRAGC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRAGC Gene

Gene Tree for RRAGC (if available)
Gene Tree for RRAGC (if available)

Paralogs for RRAGC Gene

Paralogs for RRAGC Gene

(1) SIMAP similar genes for RRAGC Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RRAGC: view

Variants for RRAGC Gene

Sequence variations from dbSNP and Humsavar for RRAGC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000113969 -- 38,851,542(+) GAAAT(C/T)AGTCT intron-variant
rs1000159960 -- 38,855,483(+) ACCAG(C/T)GGAAA intron-variant
rs1000175760 -- 38,845,169(+) ACACA(A/C)GCACA intron-variant
rs1000326502 -- 38,859,334(+) CCGCC(A/G)CCCTC intron-variant
rs1000357057 -- 38,853,339(+) TGTCA(A/T)CAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RRAGC Gene

Variant ID Type Subtype PubMed ID
nsv1078344 CNV deletion 25765185

Variation tolerance for RRAGC Gene

Residual Variation Intolerance Score: 34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRAGC Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRAGC Gene

Disorders for RRAGC Gene

MalaCards: The human disease database

(2) MalaCards diseases for RRAGC Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
birt-hogg-dube syndrome
  • birt-hogg-dubé syndrome
dilated cardiomyopathy
  • congestive cardiomyopathy
- elite association - COSMIC cancer census association via MalaCards
Search RRAGC in MalaCards View complete list of genes associated with diseases


  • Note=RRAGC mutations have been found in a patient with idiopathic dilated cardiomyopathy with ventricular dilation and systolic dysfunction, bilateral cataracts, and mild facial dysmorphisms. {ECO:0000269 PubMed:27234373}.

Relevant External Links for RRAGC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RRAGC: view

No data available for Genatlas for RRAGC Gene

Publications for RRAGC Gene

  1. Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. (PMID: 11073942) Sekiguchi T … Nishimoto T (The Journal of biological chemistry 2001) 2 3 4 60
  2. De novo RRAGC mutation activates mTORC1 signaling in syndromic fetal dilated cardiomyopathy. (PMID: 27234373) Long PA … Olson TM (Human genetics 2016) 3 4 60
  3. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. (PMID: 25561175) Rebsamen M … Superti-Furga G (Nature 2015) 3 4 60
  4. Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. (PMID: 25567906) Wang S … Sabatini DM (Science (New York, N.Y.) 2015) 3 4 60
  5. Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling. (PMID: 25259925) Peng M … Li MO (Cell 2014) 3 4 60

Products for RRAGC Gene

  • Addgene plasmids for RRAGC

Sources for RRAGC Gene

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