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RRAGC Gene

protein-coding   GIFtS: 56
GCID: GC01M039303

Ras-Related GTP Binding C

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ras-Related GTP Binding C1 2     Rag C Protein2
TIB9292 3     Ras-Related GTP-Binding Protein C2
GTPase-Interacting Protein 22 3     RagC3
RAGC2 5     Rag C3
GTR22     

External Ids:    HGNC: 199021   Entrez Gene: 641212   Ensembl: ENSG000001169547   OMIM: 6082675   UniProtKB: Q9HB903   

Export aliases for RRAGC gene to outside databases

Previous GC identifers: GC01M038767 GC01M038718 GC01M038717 GC01M038974 GC01M039076 GC01M037423


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RRAGC Gene:
This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine
nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the
cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Dec 2012)

GeneCards Summary for RRAGC Gene:
RRAGC (Ras-related GTP binding C) is a protein-coding gene. Diseases associated with RRAGC include intrahepatic cholangiocarcinoma, and cholangiocarcinoma. GO annotations related to this gene include GTPase activity and protein heterodimerization activity. An important paralog of this gene is RRAGD.

UniProtKB/Swiss-Prot: RRAGC_HUMAN, Q9HB90
Function: Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino
acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is
a crucial step in the activation of the TOR signaling cascade by amino acids

Gene Wiki entry for RRAGC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the RRAGC gene promoter:
         SRF   SRF (504 AA)   Tal-1beta   AP-2gamma   E47   C/EBPalpha   FOXO4   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRRAGC promoter sequence
   Search Chromatin IP Primers for RRAGC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RRAGC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34

RRAGC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RRAGC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M039303:  view genomic region     (about GC identifiers)

Start:
39,303,870 bp from pter      End:
39,325,495 bp from pter
Size:
21,626 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RRAGC_HUMAN, Q9HB90 (See protein sequence)
Recommended Name: Ras-related GTP-binding protein C  
Size: 399 amino acids; 44224 Da
Subunit: Forms a heterodimer with RRAGA, in a sequence-independent manner, and RRAGB. Heterodimerization
stabilizes proteins of the heterodimer. In complex with RRAGA or RRAGB, interacts with RPTOR; this interaction is
particularly efficient with GTP-loaded RRAGB and GDP-loaded RRAGC. Interacts with NOL8. Interacts with SH3BP4;
the interaction with this negative regulator is most probably direct, preferentially occurs with the inactive
GDP-bound form of RRAGB, is negatively regulated by amino acids and prevents interaction with RPTOR
Sequence caution: Sequence=BAB14548.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for RRAGC:
3LLU (3D)    
Secondary accessions: Q9H202 Q9H8Q8

Explore the universe of human proteins at neXtProt for RRAGC: NX_Q9HB90

Explore proteomics data for RRAGC at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RRAGC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258780.1  NP_071440.1  

    ENSEMBL proteins: 
     ENSP00000362092  

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    Cloud-Clone Corp. CLIAs for RRAGC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR006762 Gtr1_RagA

    Graphical View of Domain Structure for InterPro Entry Q9HB90

    ProtoNet protein and cluster: Q9HB90

    1 Blocks protein domain: IPB000463 Cytosolic fatty-acid binding protein

    UniProtKB/Swiss-Prot: RRAGC_HUMAN, Q9HB90
    Similarity: Belongs to the GTR/RAG GTP-binding protein family


    RRAGC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RRAGC_HUMAN, Q9HB90
    Function: Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino
    acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is
    a crucial step in the activation of the TOR signaling cascade by amino acids

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding NAS11073942
    GO:0003924GTPase activity IDA11073942
    GO:0005515protein binding IPI11073942
    GO:0005525GTP binding IDA11073942
    GO:0019003GDP binding IDA11073942
         
    RRAGC for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RRAGC
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RRAGC
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    miRNA
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    miRTarBase miRNAs that target RRAGC:
    hsa-mir-21-5p (MIRT030696), hsa-let-7e-5p (MIRT051496), hsa-mir-26b-5p (MIRT028929), hsa-mir-375 (MIRT019727), hsa-mir-29a-3p (MIRT049975)

    Block miRNA regulation of human, mouse, rat RRAGC using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate RRAGC:
    hsa-miR-188-3p hsa-miR-129-5p hsa-miR-3179 hsa-miR-504 hsa-miR-4308
    SwitchGear 3'UTR luciferase reporter plasmidRRAGC 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RRAGC

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRAGC

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRAGC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RRAGC_HUMAN, Q9HB90: Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the
    cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome5
    nucleus5
    vacuole5
    cytosol3
    endosome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA11073942
    GO:0005764lysosome IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    RRAGC for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RRAGC About    
    See pathways by source

    SuperPathContained pathways About
    1Translation Insulin regulation of translation
    mTOR signaling pathway0.34
    2Insulin receptor signalling cascade
    TOR signaling0.32
    3Translational Control
    Translational Control

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for RRAGC
        Translational Control

    1 BioSystems Pathway for RRAGC
        TOR signaling



    1 Kegg Pathway  (Kegg details for RRAGC):
        mTOR signaling pathway


    RRAGC for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including RRAGC: 
              mTOR Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RRAGC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RRAGC (Q9HB901, 2, 3 ENSP000003620924) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RRAGAQ7L5231, 2, 3, ENSP000003698994EBI-752390,EBI-752376 MINT-68464 I2D: score=12 STRING: ENSP00000369899
    RRAGBQ5VZM21, 3, ENSP000002628504EBI-752390,EBI-993049 I2D: score=3 STRING: ENSP00000262850
    RUVBL2Q9Y2303, ENSP000002214134I2D: score=4 STRING: ENSP00000221413
    RPTORQ8N1223, ENSP000003072724I2D: score=2 STRING: ENSP00000307272
    LAMTOR1Q6IAA83, ENSP000002786714I2D: score=1 STRING: ENSP00000278671
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IDA11073942
    GO:0006351transcription, DNA-templated NAS11073942
    GO:0006915apoptotic process NAS11073942
    GO:0007264small GTPase mediated signal transduction TAS11073942
    GO:0008380RNA splicing NAS11073942

    RRAGC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RRAGC

    3 HMDB Compounds for RRAGC    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RRAGC gene (2 alternative transcripts): 
    NM_001271851.1  NM_022157.3  

    Unigene Cluster for RRAGC:

    Ras-related GTP binding C
    Hs.532461  [show with all ESTs]
    Unigene Representative Sequence: NM_022157
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373001(uc010oim.1 uc001ccq.2 uc001ccr.2) ENST00000474456
    ENST00000493015 ENST00000496778
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate RRAGC:
    hsa-miR-188-3p hsa-miR-129-5p hsa-miR-3179 hsa-miR-504 hsa-miR-4308
    SwitchGear 3'UTR luciferase reporter plasmidRRAGC 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RRAGC
      QuantiFast Probe-based Assays in human, mouse, rat RRAGC

    Additional mRNA sequence: 

    AF131773.1 AF272035.1 AF323609.1 AK023373.1 AK092808.1 AK298573.1 AK298788.1 AK315791.1 
    BC016668.1 

    12 DOTS entries:

    DT.75116118  DT.97811754  DT.99975635  DT.100022447  DT.99933700  DT.91926416  DT.95093772  DT.100781057 
    DT.121348309  DT.95085474  DT.95175502  DT.105494 

    Selected AceView cDNA sequences (see all 538):

    AL525412 CR613581 BQ015285 BU579993 AW514314 CK825041 AA171713 BI771507 
    AY126343 BU947399 BU732697 AW513447 AW957454 BM749263 BC008686 AW302161 
    AI076839 AU123841 BM830565 AA504831 BU947961 CB159363 BI908254 BU618840 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RRAGC    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b
    SP1:                                            -                                 
    SP2:                                -           -                                 
    SP3:                    -                       -                                 
    SP4:                                                                              


    ECgene alternative splicing isoforms for RRAGC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RRAGC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGATATCCA
    RRAGC Expression
    About this image


    RRAGC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    RRAGC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RRAGC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532461
        Pathway & Disease-focused RT2 Profiler PCR Array including RRAGC: 
              mTOR Signaling in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for RRAGC
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    QuantiFast Probe-based Assays in human, mouse, rat RRAGC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRAGC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RRAGC gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rragc1 , 5 Ras-related GTP binding C1, 5 92.04(n)1
    96.48(a)1
      4 (57.42 cM)5
    541701  NM_017475.21  NP_059503.21 
     1239174465 
    chicken
    (Gallus gallus)
    Aves RRAGC1 Ras-related GTP binding C 81.54(n)
    91.98(a)
      419605  NM_001030896.1  NP_001026067.1 
    lizard
    (Anolis carolinensis)
    Reptilia RRAGC6
    Ras-related GTP binding C
    90(a)
    1 ↔ 1
    GL343426.1(738539-758705)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.70052 Xenopus laevis transcribed sequence with strong similarity more 82.02(n)    BJ622507.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rragca1 Ras-related GTP binding Ca 75.18(n)
    87.11(a)
      573492  NM_001020635.1  NP_001018471.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RagC1 RagC 67.41(n)
    77.56(a)
      35793  NM_136517.2  NP_610361.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ragc-11 ragc-1 54.51(n)
    51.79(a)
      178084  NM_069786.4  NP_502187.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GTR2(YGR163W)4 Putative GTP binding protein that negatively regulates more   --   7(827552-828577) 853072  NP_011679.1 


    ENSEMBL Gene Tree for RRAGC (if available)
    TreeFam Gene Tree for RRAGC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RRAGC gene
    RRAGD2  
    1 SIMAP similar gene for RRAGC using alignment to 2 protein entries:     RRAGC_HUMAN (see all proteins):
    RRAGD

    RRAGC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RRAGC (see all 475)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1825878051,2
    --39303499(+) GAATCA/GGTACA 2 -- ds50010--------
    rs799222551,2
    C,F--39303614(+) TTGTGT/GATATG 2 -- ds50012Minor allele frequency- G:0.05WA NA 238
    rs1881613691,2
    --39303696(+) ATACCC/TAGACA 2 -- ds50010--------
    rs754093381,2
    F--39303813(+) AAAGTG/AGGACA 2 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1929144491,2
    --39303825(+) CCCAAC/TGTTCC 2 -- ds50010--------
    rs1419905861,2
    --39303899(+) TACCCA/GTTTCA 2 -- ut310--------
    rs1851317461,2
    --39303909(+) ATATAC/TAGTTC 2 -- ut310--------
    rs114171,2
    C,F,H--39303964(+) TCACCA/GTGGTC 2 -- ut31 ese39Minor allele frequency- G:0.01MN NS EA NA 1054
    rs49706321,2
    C,F,H--39303995(+) AATCAT/CCTGCA 2 -- ut31 ese316Minor allele frequency- C:0.11NA WA CSA EA 520
    rs1905604481,2
    --39304048(+) ATACAC/TATTGC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for RRAGC (39303870 - 39325495 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RRAGC: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RRAGC
    DNA2.0 Custom Variant and Variant Library Synthesis for RRAGC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608267    OMIM disorders: --

    11 diseases for RRAGC:    
    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    tonsillitis    oral squamous cell carcinoma
    ataxia    squamous cell carcinoma    malaria    thyroiditis
    cerebritis    endotheliitis    prostatitis


    RRAGC for disorders           About GeneDecksing


    Export disorders for RRAGC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RRAGC gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with RRAGC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. (PubMed id 11073942)1, 2, 3 Sekiguchi T.... Nishimoto T. (J. Biol. Chem. 2001)
    2. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. (PubMed id 18497260)1, 2 Sancak Y.... Sabatini D.M. (Science 2008)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D. (PubMed id 14660641)1, 2 Sekiguchi T....Nishimoto T. (J. Biol. Chem. 2004)
    7. Adenovirus immunoregulatory genes and their cellular targets. (PubMed id 11145883)1, 2 Horwitz M.S. (Virology 2001)
    8. K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells. (PubMed id 23911927)1 Linares J.F....Diaz-Meco M.T. (Mol. Cell 2013)
    9. Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) is a negative regulator of the mammalian target of rapamycin complex 1 (mTORC1). (PubMed id 23184942)1 Li L. and Guan K.L. (J. Biol. Chem. 2013)
    10. The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. (PubMed id 24095279)1 Tsun Z.Y....Sabatini D.M. (Mol. Cell 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64121 HGNC: 19902 AceView: MYCBPandRHBDL2andRRAGCandGJA10 Ensembl:ENSG00000116954 euGenes: HUgn64121
    ECgene: RRAGC Kegg: 64121 H-InvDB: RRAGC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RRAGC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RRAGC gene:
    Search GeneIP for patents involving RRAGC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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