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Aliases for RRAGB Gene

Aliases for RRAGB Gene

  • Ras Related GTP Binding B 2 3 5
  • Rag B 3 4
  • RAGB 3 4
  • Ras-Related GTP-Binding Protein B 3
  • Ras-Related GTP Binding B 2
  • GTP-Binding Protein RagB 3
  • BA465E19.1 3

External Ids for RRAGB Gene

Previous GeneCards Identifiers for RRAGB Gene

  • GC0XP054349
  • GC0XP054710
  • GC0XP054711
  • GC0XP055627
  • GC0XP052798

Summaries for RRAGB Gene

Entrez Gene Summary for RRAGB Gene

  • Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for RRAGB Gene

RRAGB (Ras Related GTP Binding B) is a Protein Coding gene. Diseases associated with RRAGB include Parasitic Helminthiasis Infectious Disease. Among its related pathways are RET signaling and Translational Control. GO annotations related to this gene include GTP binding and guanyl ribonucleotide binding. An important paralog of this gene is RRAGA.

UniProtKB/Swiss-Prot for RRAGB Gene

  • Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway.

Gene Wiki entry for RRAGB Gene

Additional gene information for RRAGB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRAGB Gene

Genomics for RRAGB Gene

Regulatory Elements for RRAGB Gene

Enhancers for RRAGB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH055716 1 ENCODE 0.7 +0.3 348 2 PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 YY1 GTF3C2 ELK1 ZNF207 KLF8 APEX2 ENSG00000227486 MAGEH1 RRAGB
GH0XH055712 0.7 Ensembl ENCODE 0.7 -4.1 -4050 2 JUN RELA ENSG00000227486 RRAGB PIR34099
GH0XH055710 0.6 ENCODE 0.4 -6.4 -6429 1 SMARCC1 JUND JUN MAX FOS NR2F2 FOXR2 MAGEH1 RRAGB PIR34099
GH0XH055778 0.4 ENCODE 0.2 +60.8 60826 0 GATA3 RRAGB ENSG00000227486
GH0XH055866 0.7 ENCODE 0.1 +150.2 150215 2 EBF1 BATF EED ATF7 RUNX3 IKZF2 ZNF687 NR2F1 JUNB DPF2 ENSG00000227486 MAGEH1 RRAGB
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RRAGB on UCSC Golden Path with GeneCards custom track

Promoters for RRAGB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000246774 423 1801 PKNOX1 MLX ARID4B SIN3A YY1 GTF3C2 ZNF207 ZNF143 FOS RUNX3

Genomic Location for RRAGB Gene

Chromosome:
X
Start:
55,717,677 bp from pter
End:
55,759,333 bp from pter
Size:
41,657 bases
Orientation:
Plus strand

Genomic View for RRAGB Gene

Genes around RRAGB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRAGB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRAGB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRAGB Gene

Proteins for RRAGB Gene

  • Protein details for RRAGB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZM2-RRAGB_HUMAN
    Recommended name:
    Ras-related GTP-binding protein B
    Protein Accession:
    Q5VZM2
    Secondary Accessions:
    • A8K042
    • Q15348
    • Q8N3T0

    Protein attributes for RRAGB Gene

    Size:
    374 amino acids
    Molecular mass:
    43250 Da
    Quaternary structure:
    • Interacts with RRAGC and RRAGD; heterodimerization stabilizes RRAG proteins (PubMed:11073942). In complex with RRAGC, but not with RRAGA, interacts with RPTOR; this interaction is particularly efficient with GTP-loaded RRAGB and GDP-loaded RRAGC (PubMed:18497260). Interacts with SH3BP4; the interaction with this negative regulator is most probably direct, preferentially occurs with the inactive GDP-bound form of RRAGB, is negatively regulated by amino acids and prevents interaction with RPTOR (PubMed:22575674). Interacts with the GATOR1 complex; inactivates RRAGB (PubMed:23723238). The Rag heterodimer interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906). Interacts with SESN1, SESN2 AND SESN3 (PubMed:25259925).

    Alternative splice isoforms for RRAGB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RRAGB Gene

Post-translational modifications for RRAGB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RRAGB (RRAGB)
  • Santa Cruz Biotechnology (SCBT) Antibodies for RRAGB

No data available for DME Specific Peptides for RRAGB Gene

Domains & Families for RRAGB Gene

Gene Families for RRAGB Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RRAGB Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RRAGB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VZM2

UniProtKB/Swiss-Prot:

RRAGB_HUMAN :
  • Belongs to the GTR/RAG GTP-binding protein family.
Family:
  • Belongs to the GTR/RAG GTP-binding protein family.
genes like me logo Genes that share domains with RRAGB: view

Function for RRAGB Gene

Molecular function for RRAGB Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
The activation of GTP-binding proteins is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). The GATOR1 complex functions as a GAP and stimulates RRAGB GTPase activity to turn it into its inactive GDP-bound form.
UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway.

Phenotypes From GWAS Catalog for RRAGB Gene

Gene Ontology (GO) - Molecular Function for RRAGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 23723238
GO:0005515 protein binding IPI 11073942
GO:0005525 GTP binding IMP,IDA 22424946
GO:0032561 guanyl ribonucleotide binding IDA 22575674
GO:0046982 protein heterodimerization activity IMP 22424946
genes like me logo Genes that share ontologies with RRAGB: view
genes like me logo Genes that share phenotypes with RRAGB: view

Animal Model Products

CRISPR Products

miRNA for RRAGB Gene

miRTarBase miRNAs that target RRAGB

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RRAGB
  • Applied Biological Materials Clones for RRAGB
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRAGB Gene

Localization for RRAGB Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRAGB Gene

Cytoplasm. Lysosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRAGB gene
Compartment Confidence
cytosol 5
lysosome 5
nucleus 4
endosome 4
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RRAGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IDA 9394008
GO:0005764 lysosome IEA,IDA 20381137
GO:0005765 lysosomal membrane IDA 17897319
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RRAGB: view

Pathways & Interactions for RRAGB Gene

genes like me logo Genes that share pathways with RRAGB: view

Pathways by source for RRAGB Gene

Gene Ontology (GO) - Biological Process for RRAGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest TAS --
GO:0010506 regulation of autophagy IBA --
GO:0016241 regulation of macroautophagy TAS --
GO:0032006 regulation of TOR signaling IGI 23723238
GO:0032008 positive regulation of TOR signaling IMP 22575674
genes like me logo Genes that share ontologies with RRAGB: view

No data available for SIGNOR curated interactions for RRAGB Gene

Drugs & Compounds for RRAGB Gene

(3) Drugs for RRAGB Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RRAGB: view

Transcripts for RRAGB Gene

Unigene Clusters for RRAGB Gene

Ras-related GTP binding B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RRAGB
  • Applied Biological Materials Clones for RRAGB
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RRAGB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for RRAGB Gene

GeneLoc Exon Structure for
RRAGB
ECgene alternative splicing isoforms for
RRAGB

Expression for RRAGB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RRAGB Gene

Protein differential expression in normal tissues from HIPED for RRAGB Gene

This gene is overexpressed in Heart (23.1), Peripheral blood mononuclear cells (16.2), and Frontal cortex (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RRAGB Gene



Protein tissue co-expression partners for RRAGB Gene

NURSA nuclear receptor signaling pathways regulating expression of RRAGB Gene:

RRAGB

SOURCE GeneReport for Unigene cluster for RRAGB Gene:

Hs.50282

Evidence on tissue expression from TISSUES for RRAGB Gene

  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with RRAGB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RRAGB Gene

Orthologs for RRAGB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RRAGB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RRAGB 33 34
  • 99.9 (n)
oppossum
(Monodelphis domestica)
Mammalia RRAGB 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RRAGB 33 34
  • 94.92 (n)
dog
(Canis familiaris)
Mammalia RRAGB 33 34
  • 94.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 93 (a)
ManyToMany
-- 34
  • 88 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Rragb 33 16 34
  • 92.42 (n)
chicken
(Gallus gallus)
Aves -- 34
  • 87 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 91 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii rraga 34
  • 95 (a)
OneToMany
wufc68h09 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002991 33
  • 70.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta RagA 33 34
  • 67.91 (n)
worm
(Caenorhabditis elegans)
Secernentea raga-1 33 34
  • 62.71 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GTR1 34 36
  • 52 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6548 34
  • 74 (a)
OneToMany
Species where no ortholog for RRAGB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RRAGB Gene

ENSEMBL:
Gene Tree for RRAGB (if available)
TreeFam:
Gene Tree for RRAGB (if available)

Paralogs for RRAGB Gene

Paralogs for RRAGB Gene

(1) SIMAP similar genes for RRAGB Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RRAGB: view

Variants for RRAGB Gene

Sequence variations from dbSNP and Humsavar for RRAGB Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000251321 -- 55,734,785(+) TCTTA(A/G)CACTG intron-variant
rs1000274761 -- 55,756,899(+) GCAAT(G/T)AGCCA intron-variant
rs1000480088 -- 55,745,273(+) AAATT(A/G)TGACA intron-variant
rs1000553201 -- 55,743,188(+) AAGCA(A/G)TGCTG intron-variant
rs1000622856 -- 55,740,499(+) CAAAC(G/T)CTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RRAGB Gene

Variant ID Type Subtype PubMed ID
esv3352059 CNV insertion 20981092

Variation tolerance for RRAGB Gene

Residual Variation Intolerance Score: 19.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRAGB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RRAGB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRAGB Gene

Disorders for RRAGB Gene

MalaCards: The human disease database

(1) MalaCards diseases for RRAGB Gene - From: DISEASES

Disorder Aliases PubMed IDs
parasitic helminthiasis infectious disease
  • helminth infection
- elite association - COSMIC cancer census association via MalaCards
Search RRAGB in MalaCards View complete list of genes associated with diseases

Relevant External Links for RRAGB

Genetic Association Database (GAD)
RRAGB
Human Genome Epidemiology (HuGE) Navigator
RRAGB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RRAGB
genes like me logo Genes that share disorders with RRAGB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RRAGB Gene

Publications for RRAGB Gene

  1. Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases. (PMID: 7499430) Schürmann A … Joost HG (The Journal of biological chemistry 1995) 2 3 4 22 60
  2. RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway. (PMID: 9394008) Hirose E … Nishimoto T (Journal of cell science 1998) 2 3 4 60
  3. Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. (PMID: 25567906) Wang S … Sabatini DM (Science (New York, N.Y.) 2015) 3 4 60
  4. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. (PMID: 25561175) Rebsamen M … Superti-Furga G (Nature 2015) 3 4 60
  5. Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling. (PMID: 25259925) Peng M … Li MO (Cell 2014) 3 4 60

Products for RRAGB Gene

  • Addgene plasmids for RRAGB

Sources for RRAGB Gene

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