Aliases for RRAGB Gene
External Ids for RRAGB Gene
Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for RRAGB Gene
RRAGB (Ras-Related GTP Binding B) is a Protein Coding gene. Diseases associated with RRAGB include taeniasis and clonorchiasis. Among its related pathways are Translational Control and PI3K / Akt Signaling. GO annotations related to this gene include GTP binding and guanyl ribonucleotide binding. An important paralog of this gene is RRAGA.
UniProtKB/Swiss-Prot for RRAGB Gene
Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway.