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Aliases for RRAGB Gene

Aliases for RRAGB Gene

  • Ras-Related GTP Binding B 2 3
  • Rag B 3 4
  • RAGB 3 4
  • GTP-Binding Protein RagB 3
  • BA465E19.1 3

External Ids for RRAGB Gene

Previous GeneCards Identifiers for RRAGB Gene

  • GC0XP054349
  • GC0XP054710
  • GC0XP054711
  • GC0XP055627
  • GC0XP052798

Summaries for RRAGB Gene

Entrez Gene Summary for RRAGB Gene

  • Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for RRAGB Gene

RRAGB (Ras-Related GTP Binding B) is a Protein Coding gene. Diseases associated with RRAGB include parasitic helminthiasis infectious disease. Among its related pathways are Signaling by GPCR and mTOR signalling. GO annotations related to this gene include GTP binding and guanyl ribonucleotide binding. An important paralog of this gene is RRAGA.

UniProtKB/Swiss-Prot for RRAGB Gene

  • Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates to the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway.

Gene Wiki entry for RRAGB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRAGB Gene

Genomics for RRAGB Gene

Regulatory Elements for RRAGB Gene

Genomic Location for RRAGB Gene

Chromosome:
X
Start:
55,717,677 bp from pter
End:
55,759,333 bp from pter
Size:
41,657 bases
Orientation:
Plus strand

Genomic View for RRAGB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RRAGB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRAGB Gene

Proteins for RRAGB Gene

  • Protein details for RRAGB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZM2-RRAGB_HUMAN
    Recommended name:
    Ras-related GTP-binding protein B
    Protein Accession:
    Q5VZM2
    Secondary Accessions:
    • A8K042
    • Q15348
    • Q8N3T0

    Protein attributes for RRAGB Gene

    Size:
    374 amino acids
    Molecular mass:
    43250 Da
    Quaternary structure:
    • Interacts with RRAGC and RRAGD; heterodimerization stabilizes RRAG proteins (PubMed:11073942). In complex with RRAGC, but not with RRAGA, interacts with RPTOR; this interaction is particularly efficient with GTP-loaded RRAGB and GDP-loaded RRAGC (PubMed:18497260). Interacts with SH3BP4; the interaction with this negative regulator is most probably direct, preferentially occurs with the inactive GDP-bound form of RRAGB, is negatively regulated by amino acids and prevents interaction with RPTOR (PubMed:22575674). Interacts with the GATOR1 complex; inactivates RRAGB (PubMed:23723238). The Rag heterodimer interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906).

    Alternative splice isoforms for RRAGB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RRAGB Gene

Proteomics data for RRAGB Gene at MOPED

Post-translational modifications for RRAGB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RRAGB Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RRAGB (RRAGB)

No data available for DME Specific Peptides for RRAGB Gene

Domains & Families for RRAGB Gene

Protein Domains for RRAGB Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RRAGB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VZM2

UniProtKB/Swiss-Prot:

RRAGB_HUMAN :
  • Belongs to the GTR/RAG GTP-binding protein family.
Family:
  • Belongs to the GTR/RAG GTP-binding protein family.
genes like me logo Genes that share domains with RRAGB: view

No data available for Gene Families for RRAGB Gene

Function for RRAGB Gene

Molecular function for RRAGB Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
The activation of GTP-binding proteins is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). The GATOR1 complex functions as a GAP and stimulates RRAGB GTPase activity to turn it into its inactive GDP-bound form.
UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates to the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway.

Gene Ontology (GO) - Molecular Function for RRAGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 23723238
GO:0005515 protein binding IPI 11073942
GO:0005525 GTP binding IMP 23723238
GO:0032561 guanyl ribonucleotide binding IDA 22575674
genes like me logo Genes that share ontologies with RRAGB: view
genes like me logo Genes that share phenotypes with RRAGB: view

Animal Model Products

miRNA for RRAGB Gene

miRTarBase miRNAs that target RRAGB

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RRAGB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RRAGB Gene

Localization for RRAGB Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRAGB Gene

Cytoplasm. Lysosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RRAGB Gene COMPARTMENTS Subcellular localization image for RRAGB gene
Compartment Confidence
lysosome 5
vacuole 5
golgi apparatus 4
endosome 3

Gene Ontology (GO) - Cellular Components for RRAGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 9394008
GO:0005764 lysosome IDA 20381137
GO:0005765 lysosomal membrane IDA 17897319
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RRAGB: view

Pathways & Interactions for RRAGB Gene

genes like me logo Genes that share pathways with RRAGB: view

Pathways by source for RRAGB Gene

2 Cell Signaling Technology pathways for RRAGB Gene
1 BioSystems pathway for RRAGB Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RRAGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007050 cell cycle arrest TAS --
GO:0008286 insulin receptor signaling pathway TAS --
GO:0009267 cellular response to starvation IBA --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with RRAGB: view

No data available for SIGNOR curated interactions for RRAGB Gene

Drugs & Compounds for RRAGB Gene

(3) Drugs for RRAGB Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RRAGB: view

Transcripts for RRAGB Gene

Unigene Clusters for RRAGB Gene

Ras-related GTP binding B:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RRAGB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RRAGB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for RRAGB Gene

GeneLoc Exon Structure for
RRAGB
ECgene alternative splicing isoforms for
RRAGB

Expression for RRAGB Gene

mRNA expression in normal human tissues for RRAGB Gene

Protein differential expression in normal tissues from HIPED for RRAGB Gene

This gene is overexpressed in Heart (23.1), Peripheral blood mononuclear cells (16.2), and Frontal cortex (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RRAGB Gene



SOURCE GeneReport for Unigene cluster for RRAGB Gene Hs.50282

genes like me logo Genes that share expression patterns with RRAGB: view

Protein tissue co-expression partners for RRAGB Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RRAGB Gene

Orthologs for RRAGB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RRAGB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RRAGB 35
  • 94.92 (n)
  • 98.66 (a)
RRAGB 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RRAGB 35
  • 94.82 (n)
  • 98.39 (a)
RRAGB 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rragb 35
  • 92.42 (n)
  • 97.59 (a)
Rragb 16
Rragb 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RRAGB 35
  • 99.9 (n)
  • 100 (a)
RRAGB 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RRAGB 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
ManyToMany
-- 36
  • 93 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 87 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 91 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii wufc68h09 35
rraga 36
  • 95 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002991 35
  • 70.72 (n)
  • 86.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta RagA 35
  • 67.91 (n)
  • 80.74 (a)
RagA 36
  • 77 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea raga-1 35
  • 62.71 (n)
  • 67.12 (a)
raga-1 36
  • 63 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GTR1 36
  • 52 (a)
OneToMany
GTR1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6548 36
  • 74 (a)
OneToMany
Species with no ortholog for RRAGB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RRAGB Gene

ENSEMBL:
Gene Tree for RRAGB (if available)
TreeFam:
Gene Tree for RRAGB (if available)

Paralogs for RRAGB Gene

Paralogs for RRAGB Gene

(1) SIMAP similar genes for RRAGB Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RRAGB: view

Variants for RRAGB Gene

Sequence variations from dbSNP and Humsavar for RRAGB Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs913440 -- 55,718,650(-) ACTCC(C/T)CCAGC intron-variant
rs1007153 -- 55,751,706(-) AAAGA(A/G)TGCTT intron-variant
rs1473760 -- 55,722,467(-) CAAGA(A/C)AGCAA intron-variant
rs1473761 -- 55,722,387(-) CAAAT(C/T)CCCCA intron-variant
rs1473762 -- 55,720,808(-) CTCCG(C/T)CTCCC intron-variant

Variation tolerance for RRAGB Gene

Residual Variation Intolerance Score: 19.38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRAGB Gene

HapMap Linkage Disequilibrium report
RRAGB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RRAGB Gene

Disorders for RRAGB Gene

MalaCards: The human disease database

(1) MalaCards diseases for RRAGB Gene - From: DISEASES

Disorder Aliases PubMed IDs
parasitic helminthiasis infectious disease
  • helminthosis
- elite association
Search RRAGB in MalaCards View complete list of genes associated with diseases

Relevant External Links for RRAGB

Genetic Association Database (GAD)
RRAGB
Human Genome Epidemiology (HuGE) Navigator
RRAGB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RRAGB
genes like me logo Genes that share disorders with RRAGB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RRAGB Gene

Publications for RRAGB Gene

  1. Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagBl) with remote similarity to the Ras-related GTPases. (PMID: 7499430) Schuermann A. … Joost H.-G. (J. Biol. Chem. 1995) 2 23 67
  2. RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway. (PMID: 9394008) Hirose E. … Nishimoto T. (J. Cell Sci. 1998) 2 67
  3. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. (PMID: 25561175) Rebsamen M. … Superti-Furga G. (Nature 2015) 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. (PMID: 25567906) Wang S. … Sabatini D.M. (Science 2015) 67

Products for RRAGB Gene

Sources for RRAGB Gene

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