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RRAGB Gene

protein-coding   GIFtS: 56
GCID: GC0XP055760

Ras-Related GTP Binding B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ras-Related GTP Binding B1 2     GTP-Binding Protein RagB2
Rag B2 3     Ras-Related GTP-Binding Protein B2
RAGB2 5     RagB3
bA465E19.12     

External Ids:    HGNC: 199011   Entrez Gene: 103252   Ensembl: ENSG000000837507   OMIM: 3007255   UniProtKB: Q5VZM23   

Export aliases for RRAGB gene to outside databases

Previous GC identifers: GC0XP054349 GC0XP054710 GC0XP054711 GC0XP055627 GC0XP052798


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RRAGB Gene:
Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated,
GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are
operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the
Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which
are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3).
Transcript variants encoding distinct isoforms have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for RRAGB Gene:
RRAGB (Ras-related GTP binding B) is a protein-coding gene. Diseases associated with RRAGB include taeniasis, and clonorchiasis. GO annotations related to this gene include guanyl ribonucleotide binding and GTP binding. An important paralog of this gene is RRAGA.

UniProtKB/Swiss-Prot: RRAGB_HUMAN, Q5VZM2
Function: Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino
acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is
a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase
pathway

Gene Wiki entry for RRAGB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011630.15  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RRAGB gene promoter:
         SRF   HTF   SRF (504 AA)   POU6F1 (c2)   Evi-1   MZF-1   E2F   POU2F1   E2F-1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRRAGB promoter sequence
   Search Chromatin IP Primers for RRAGB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RRAGB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.21   Ensembl cytogenetic band:  Xp11.21   HGNC cytogenetic band: Xp11.21

RRAGB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RRAGB gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP055760:  view genomic region     (about GC identifiers)

Start:
55,744,110 bp from pter      End:
55,785,207 bp from pter
Size:
41,098 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RRAGB_HUMAN, Q5VZM2 (See protein sequence)
Recommended Name: Ras-related GTP-binding protein B  
Size: 374 amino acids; 43250 Da
Subunit: Interacts with RRAGC and RRAGD; heterodimerization stabilizes RRAG proteins. In complex with RRAGC, but
not with RRAGA, interacts with RPTOR; this interaction is particularly efficient with GTP-loaded RRAGB and
GDP-loaded RRAGC. Interacts with SH3BP4; the interaction with this negative regulator is most probably direct,
preferentially occurs with the inactive GDP-bound form of RRAGB, is negatively regulated by amino acids and
prevents interaction with RPTOR
Secondary accessions: A8K042 Q15348 Q8N3T0
Alternative splicing: 2 isoforms:  Q5VZM2-1   Q5VZM2-2   

Explore the universe of human proteins at neXtProt for RRAGB: NX_Q5VZM2

Explore proteomics data for RRAGB at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RRAGB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_006055.3  NP_057740.2  

    ENSEMBL proteins: 
     ENSP00000364077   ENSP00000410630   ENSP00000262850  

    RRAGB Human Recombinant Protein Products:

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    Novus Biologicals RRAGB Protein
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    LSBio Antibodies in human, mouse, rat for RRAGB

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    Cloud-Clone Corp. CLIAs for RRAGB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR006762 Gtr1_RagA

    Graphical View of Domain Structure for InterPro Entry Q5VZM2

    ProtoNet protein and cluster: Q5VZM2

    UniProtKB/Swiss-Prot: RRAGB_HUMAN, Q5VZM2
    Similarity: Belongs to the GTR/RAG GTP-binding protein family


    RRAGB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RRAGB_HUMAN, Q5VZM2
    Function: Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino
    acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is
    a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase
    pathway

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005515protein binding IPI11073942
    GO:0005525GTP binding IDA7499430
    GO:0032561guanyl ribonucleotide binding IDA--
         
    RRAGB for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RRAGB:
     Decreased p24 protein expressi  Increased cilium length after  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RRAGB
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RRAGB
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    miRTarBase miRNAs that target RRAGB:
    hsa-mir-375 (MIRT019667)

    Block miRNA regulation of human, mouse, rat RRAGB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RRAGB (see all 9):
    hsa-miR-361-5p hsa-miR-4251 hsa-miR-539 hsa-miR-561 hsa-miR-1179 hsa-miR-570 hsa-miR-374a* hsa-miR-499-5p
    SwitchGear 3'UTR luciferase reporter plasmidRRAGB 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RRAGB

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    GenScript: all cDNA clones in your preferred vector (see all 2): RRAGB (NM_006064)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RRAGB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRAGB

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RRAGB_HUMAN, Q5VZM2: Cytoplasm. Lysosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome5
    vacuole5
    golgi apparatus4
    cytosol2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA9394008
    GO:0005764lysosome IDA--
    GO:0005765lysosomal membrane IDA17897319

    RRAGB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RRAGB About    
    See pathways by source

    SuperPathContained pathways About
    1Translation Insulin regulation of translation
    mTOR signaling pathway0.34
    2Insulin receptor signalling cascade
    TOR signaling0.32
    3Translational Control
    Translational Control
    4PI3K / Akt Signaling
    PI3K / Akt Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for RRAGB
        Translational Control
    PI3K / Akt Signaling

    1 BioSystems Pathway for RRAGB
        TOR signaling


    1 Kegg Pathway  (Kegg details for RRAGB):
        mTOR signaling pathway


    RRAGB for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including RRAGB: 
              mTOR Signaling in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RRAGB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RRAGB (Q5VZM21, 3 ENSP000002628504) via UniProtKB, MINT, STRING, and/or I2D (see all 98)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RRAGDQ9NQL21, 3, ENSP000003584234EBI-993049,EBI-992949 I2D: score=5 STRING: ENSP00000358423
    RRAGCQ9HB901, 3, ENSP000003620924EBI-993049,EBI-752390 I2D: score=3 STRING: ENSP00000362092
    LAMTOR1Q6IAA83, ENSP000002786714I2D: score=1 STRING: ENSP00000278671
    LAMTOR2Q9Y2Q53, ENSP000003572884I2D: score=1 STRING: ENSP00000357288
    LAMTOR3Q9UHA43, ENSP000002265224I2D: score=1 STRING: ENSP00000226522
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction ----
    GO:0032008positive regulation of TOR signaling IMP--
    GO:0034613cellular protein localization IMP--
    GO:0071230cellular response to amino acid stimulus IMP--

    RRAGB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RRAGB

    3 HMDB Compounds for RRAGB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RRAGB gene (2 alternative transcripts): 
    NM_006064.4  NM_016656.3  

    Unigene Cluster for RRAGB:

    Ras-related GTP binding B
    Hs.50282  [show with all ESTs]
    Unigene Representative Sequence: NM_016656
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374941(uc004dup.3 uc004duq.3) ENST00000414239 ENST00000262850
    ENST00000498762 ENST00000474757 ENST00000475061

    miRNA
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    Block miRNA regulation of human, mouse, rat RRAGB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RRAGB (see all 9):
    hsa-miR-361-5p hsa-miR-4251 hsa-miR-539 hsa-miR-561 hsa-miR-1179 hsa-miR-570 hsa-miR-374a* hsa-miR-499-5p
    SwitchGear 3'UTR luciferase reporter plasmidRRAGB 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat RRAGB

    Additional mRNA sequence: 

    AK289407.1 AL831926.1 BC034726.1 X90530.1 

    6 DOTS entries:

    DT.100020215  DT.453915  DT.91701020  DT.100740378  DT.100739207  DT.97768494 

    Selected AceView cDNA sequences (see all 81):

    NM_016656 BQ638325 AW949918 AA338872 AA234339 BX439588 AA662307 BQ960958 
    NM_006064 BM548718 BC034726 BM721671 BQ719383 AL537472 AL711517 AA421896 
    CD676755 BX455440 BX328035 AL711828 AL573197 AI989294 BF694335 AL831926 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RRAGB    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                                            -           -                           
    SP2:              -                             -           -                           
    SP3:                                                                                    
    SP4:                                                                                    


    ECgene alternative splicing isoforms for RRAGB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RRAGB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTAAAAAT
    RRAGB Expression
    About this image

    RRAGB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RRAGB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.50282
        Pathway & Disease-focused RT2 Profiler PCR Array including RRAGB: 
              mTOR Signaling in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRAGB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RRAGB gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rragb1 , 5 Ras-related GTP binding B1, 5 92.42(n)1
    97.59(a)1
      X (68.46 cM)5
    2456701  NM_001004154.21  NP_001004154.11 
     1531399815 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    87(a)
    1 → many
    4(11428768-11442089)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    91(a)
    1 → many
    GL343577.1(237229-244340)
    zebrafish
    (Danio rerio)
    Actinopterygii wufc68h092 wufc68h09 82.5(n)   325358  BC049033.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RagA1 RagA 67.91(n)
    80.74(a)
      41071  NM_141593.3  NP_649850.1 
    worm
    (Caenorhabditis elegans)
    Secernentea raga-11 raga-1 62.71(n)
    67.12(a)
      174726  NM_064014.7  NP_496415.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GTR1(YML121W)4 Cytoplasmic GTP binding protein and negative regulator more   --   13(26930-27862) 854918  NP_013585.1 


    ENSEMBL Gene Tree for RRAGB (if available)
    TreeFam Gene Tree for RRAGB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RRAGB gene
    RRAGA2  
    1 SIMAP similar gene for RRAGB using alignment to 2 protein entries:     RRAGB_HUMAN (see all proteins):
    RRAGA

    RRAGB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RRAGB (see all 509)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs48262811,2
    C,F,A,H--55742195(+) TCAGTT/CTCGGG 2 -- us2k111Minor allele frequency- C:0.51NS EA NA 558
    rs1857325451,2
    --55742361(+) TTACTA/GGTCTG 2 -- us2k10--------
    rs1915903191,2
    --55742397(+) TTCCCC/TTATCC 2 -- us2k10--------
    rs48264081,2
    C--55742634(+) gccccA/Gctcct 2 -- us2k14Minor allele frequency- G:0.00NA 6
    rs48262821,2
    C,A--55742753(+) gactcC/Ttgcag 2 -- us2k14Minor allele frequency- T:0.00NA 6
    rs1813378471,2
    --55742760(+) GCAGCC/TGGAGG 2 -- us2k10--------
    rs1865089711,2
    --55742803(+) TGTAAA/TCTTGT 2 -- us2k10--------
    rs66519851,2
    C,A,H--55742874(+) TTTTGG/TTTTTT 2 -- us2k12Minor allele frequency- T:0.25NA WA 4
    rs48264091,2
    C,A,H--55743401(+) TATCAT/CGTCCT 2 -- us2k13Minor allele frequency- C:0.00NA 5
    rs48264101,2
    C,A--55743522(+) ATTTAT/CAGATG 2 -- us2k13Minor allele frequency- C:0.00NA 4

    HapMap Linkage Disequilibrium report for RRAGB (55744110 - 55785207 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RRAGB: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RRAGB
    DNA2.0 Custom Variant and Variant Library Synthesis for RRAGB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300725    OMIM disorders: --

    8 diseases for RRAGB:    
    About MalaCards
    taeniasis    clonorchiasis    paragonimiasis    echinococcosis
    cystic echinococcosis    periodontal disease    periodontitis    hiv-1

    4 diseases from the University of Copenhagen DISEASES database for RRAGB:
    Echinococcosis     Paragonimiasis     Taeniasis     Clonorchiasis

    RRAGB for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): RRAGB
    Human Genome Epidemiology (HuGE) Navigator: RRAGB (1 document)

    Export disorders for RRAGB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RRAGB gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with RRAGB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagBl) with remote similarity to the Ras-related GTPases. (PubMed id 7499430)1, 2, 3, 9 Schuermann A.... Joost H.-G. (J. Biol. Chem. 1995)
    2. RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway. (PubMed id 9394008)1, 2, 3 Hirose E.... Nishimoto T. (J. Cell Sci. 1998)
    3. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. (PubMed id 18497260)1, 2 Sancak Y.... Sabatini D.M. (Science 2008)
    4. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. (PubMed id 11073942)1, 2 Sekiguchi T.... Nishimoto T. (J. Biol. Chem. 2001)
    7. Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. (PubMed id 22424946)1 Han J.M....Kim S. (Cell 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling. (PubMed id 22575674)2 Kim Y.M....Kim D.H. (Mol. Cell 2012)
    10. Glutaminolysis activates Rag-mTORC1 signaling. (PubMed id 22749528)1 DurA!n R.V....Hall M.N. (Mol. Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10325 HGNC: 19901 AceView: RRAGB Ensembl:ENSG00000083750 euGenes: HUgn10325
    ECgene: RRAGB Kegg: 10325 H-InvDB: RRAGB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RRAGB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RRAGB gene:
    Search GeneIP for patents involving RRAGB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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