RRAGB Gene
protein-coding GIFtS: 54
GCID: GC0XP055760
|
|
Ras-related GTP binding B
| |
Aliases for RRAGB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Ras-Related GTP Binding B1 2 | | GTP-Binding Protein RagB2 | | Rag B2 3 | | Ras-Related GTP-Binding Protein B2 | | RAGB2 5 | | RagB3 | | BA465E19.11 | | |
Export aliases for RRAGB gene to outside databasesPrevious GC identifers: GC0XP054349 GC0XP054710 GC0XP054711 GC0XP055627 GC0XP052798 |
Summaries for RRAGB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for RRAGB: Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-bindingstate and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated byGTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamilyhave in common the presence of six conserved motifs involved in GTP/GDP binding, three of which arephosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3).Transcript variants encoding distinct isoforms have been identified. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: RRAGB_HUMAN, Q5VZM2Function: Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the aminoacid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is acrucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway.Involved in the RCC1/Ran-GTPase pathway Gene Wiki entry for RRAGB
|
Genomic Views for RRAGB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011630.14
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RRAGB gene promoter: SRF HTF SRF (504 AA) POU6F1 (c2) Evi-1 MZF-1 E2F POU2F1 E2F-1 POU2F1a Other transcription factors
Search SABiosciences Chromatin IP Primers for RRAGB
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RRAGB |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.21 Ensembl cytogenetic band: Xp11.21 HGNC cytogenetic band: Xp11.21RRAGB Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP055760: view genomic region
(about GC identifiers)
Start:
|
55,744,110 bp from pter |
End:
|
55,785,207 bp from pter |
Size:
|
41,098 bases |
Orientation:
|
plus strand |
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Proteins for RRAGB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: RRAGB_HUMAN, Q5VZM2 (See
protein sequence)Recommended Name: Ras-related GTP-binding protein B Size: 374 amino acids; 43250 Da
Subunit: The short isoform binds GTP (By similarity). Interacts with RRAGC and RRAGD; heterodimerization stabilizesPPAG proteins. In complex with RRAGC, but not with RRAGA, interacts with RPTOR; this interaction is particularlyefficient with GTP-loaded RRAGB and GDP-loaded RRAGC. It is regulated by amino acids, since amino acid stimulation ofcells increase the GTP-loading of RRAGB
Subcellular location: Cytoplasm. Lysosome
Secondary accessions: A8K042 Q15348 Q8N3T0Alternative splicing: 2 isoforms: Q5VZM2-1 Q5VZM2-2 Explore the universe of human proteins at neXtProt for RRAGB: NX_Q5VZM2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5VZM2 RRAGB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_006055.3 NP_057740.2 ENSEMBL proteins: ENSP00000364077 ENSP00000410630 ENSP00000262850 Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
RRAGB for ontologies About GeneDecksing
RRAGB Antibody Products: Assay Products for RRAGB: |
Protein
Domains / Families for RRAGB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RRAGB for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5VZM2ProtoNet protein and cluster: Q5VZM2 UniProtKB/Swiss-Prot: RRAGB_HUMAN, Q5VZM2Similarity: Belongs to the GTR/RAG GTP-binding protein family |
Function for RRAGB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: RRAGB_HUMAN, Q5VZM2Function: Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the aminoacid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is acrucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway.Involved in the RCC1/Ran-GTPase pathway
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RRAGB (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RRAGB (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRAGB |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
RRAGB for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for RRAGB:
|
Pathways & Interactions for RRAGB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | PI3K / Akt Signaling | | | 2 | Translational Control | | | 3 | mTOR signalling | |
Pathway sources See GeneCards unified pathways Show all pathways
2
Cell Signaling Technology (CST) Pathways for RRAGB 1 BioSystems Pathway for RRAGB 
RRAGB for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RRAGB
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
 5/14 Interacting proteins for RRAGB (Q5VZM21, 3 ENSP000002628504) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
TAS | 7499430 | | GO:0032008 | positive regulation of TOR signaling cascade |
NAS | -- | | GO:0034613 | cellular protein localization |
IMP | -- | | GO:0071230 | cellular response to amino acid stimulus |
IMP | -- |
RRAGB for ontologies About GeneDecksing
|
Drugs & Compounds for RRAGB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for RRAGB
3 HMDB Compounds for RRAGB About this table Search CenterWatch for drugs/clinical trials and news about RRAGB 
|
Transcripts for RRAGB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for RRAGB gene (2 alternative transcripts): NM_006064.4 NM_016656.3 Unigene Cluster for RRAGB: Ras-related GTP binding B Hs.50282 [show with all ESTs]Unigene Representative Sequence: NM_0166566 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374941(uc004dup.3 uc004duq.3) ENST00000414239 ENST00000262850 ENST00000498762 ENST00000474757 ENST00000475061
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RRAGB (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RRAGB (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): RRAGB (NM_006064) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RRAGB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRAGB  |
Additional cDNA sequence: AK289407.1 AL831926.1 BC034726.1 X90530.1 6 DOTS entries: DT.100020215 DT.453915 DT.91701020 DT.100740378 DT.100739207 DT.97768494 24/81 AceView cDNA sequences (see all 81): BC034726 BM548718 AA662307 NM_016656 AW949918 NM_006064 AA338872 BX439588 BQ960958 AA234339 BQ638325 BX328035 AV703127 CD676755 AL831926 BX455440 BI522245 AW952785 BQ719383 AL537472 AU120855 X90530 BF792269 BE828524 GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for RRAGB About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for RRAGB
|
Expression for RRAGB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RRAGB expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: CATTAAAAAT
About this image See RRAGB Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RRAGB
SOURCE GeneReport for Unigene cluster: Hs.50282 SABiosciences Expression via Pathway-Focused PCR Array including RRAGB:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RRAGB Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RRAGB | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RRAGB | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RRAGB | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRAGB |
Orthologs for RRAGB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RRAGB gene from 4/21 species (see all 21) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
lizard (Anolis carolinensis) |
Reptilia |
-- |
-- |
91(a) |
1 ↔ 1 |
GL343577.1(237229-244340) |
zebrafish (Danio rerio) |
Actinopterygii |
wufc68h092 |
wufc68h09 |
82.5(n) |
  |
325358 BC049033.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
RagA6 |
-- |
77(a) |
possible ortholog |
3R(4808454-4810029) |
worm (Caenorhabditis elegans) |
Secernentea |
raga-16 |
RAs-related GTP-binding protein A family member (r... |
64(a) |
1 → many |
II(11301293-11302715) |
ENSEMBL Gene Tree for RRAGB (if available) TreeFam Gene Tree for RRAGB (if available)  |
Paralogs for RRAGB gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for RRAGB gene
- RRAGA2
1 SIMAP similar gene for RRAGB using alignment to 2 protein entries: RRAGB_HUMAN (see all proteins):RRAGA
RRAGB for paralogs About GeneDecksing
|
Genomic Variants for RRAGB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr X pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for RRAGB (55744110 - 55785207 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for RRAGB: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RRAGB |
|
Disorders
/ Diseases for RRAGB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RRAGB for disorders About GeneDecksing
OMIM gene information: 300725
OMIM disorders: --
6 diseases for RRAGB: About MalaCardscystic echinococcosis echinococcosis paragonimiasis clonorchiasis periodontitis periodontal disease 4 diseases from the University of Copenhagen DISEASES database for RRAGB:Echinococcosis Paragonimiasis Taeniasis Clonorchiasis Human Genome Epidemiology (HuGE) Navigator: RRAGB (1 document) Export disorders for RRAGB gene to outside databases
|
Publications for RRAGB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RRAGB gene, integrated from 9 sources (see all 19): (articles sorted by number of sources associating them with RRAGB) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagBl) with remote similarity to the Ras-related GTPases. (PubMed id 7499430)1, 2, 3, 9 Schuermann A.... Joost H.-G. (1995)
- RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway. (PubMed id 9394008)1, 2, 3 Hirose E.... Nishimoto T. (1998)
- The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. (PubMed id 18497260)1, 2 Sancak Y....Sabatini D.M. (2008)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. (PubMed id 11073942)1, 2 Sekiguchi T.... Nishimoto T. (2001)
- Glutaminolysis activates Rag-mTORC1 signaling. (PubMed id 22749528)1 Duran R.V....Hall M.N. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- p62 is a key regulator of nutrient sensing in the mTO RC1 pathway. (PubMed id 21981924)1 Duran A....Diaz-Meco M.T. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for RRAGB gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RRAGB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RRAGB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RRAGB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for RRAGB | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RRAGB gene: Search GeneIP for patents involving RRAGB
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for RRAGB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
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 | |
 |
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