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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RRAGA Gene

protein-coding   GIFtS: 56
GCID: GC09P019049

Ras-Related GTP Binding A

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ras-Related GTP Binding A1 2     RAGA2 5
Adenovirus E3 14.7 KDa-Interacting Protein 12 3     Adenovirus E3-14.7K Interacting Protein 12
Rag A2 3     Ras-Related GTP-Binding Protein A2
FIP-12 3     RagA3
FIP12 5     

External Ids:    HGNC: 169631   Entrez Gene: 106702   Ensembl: ENSG000001558767   OMIM: 6121945   UniProtKB: Q7L5233   

Export aliases for RRAGA gene to outside databases

Previous GC identifers: GC09P019039 GC09P019010


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RRAGA Gene: 
RRAGA (Ras-related GTP binding A) is a protein-coding gene. Diseases associated with RRAGA include periodontal disease, and periodontitis, and among its related super-pathways are Transcription Receptor-mediated HIF regulation and mTOR signalling. GO annotations related to this gene include protein heterodimerization activity and protein homodimerization activity. An important paralog of this gene is RRAGB.

UniProtKB/Swiss-Prot: RRAGA_HUMAN, Q7L523
Function: Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino
acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is
a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase
pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May
alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby
affecting cell death

Gene Wiki entry for RRAGA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RRAGA gene promoter:
         STAT1   AML1a   Brachyury   CUTL1   Arnt   RORalpha1   TFIID   IRF-7A   Zic3   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRRAGA promoter sequence
   Search SABiosciences Chromatin IP Primers for RRAGA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RRAGA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22.1   Ensembl cytogenetic band:  9p22.1   HGNC cytogenetic band: 9p21.3

RRAGA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RRAGA gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P019049:  view genomic region     (about GC identifiers)

Start:
19,049,372 bp from pter      End:
19,051,023 bp from pter
Size:
1,652 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RRAGA_HUMAN, Q7L523 (See protein sequence)
Recommended Name: Ras-related GTP-binding protein A  
Size: 313 amino acids; 36566 Da
Subunit: Can occur as a homodimer or as a heterodimer with RRAGC or RRAGD in a sequence-independent manner;
heterodimerization stabilizes proteins of the heterodimer. In complex with RRAGC, but not with RRAGB, interacts
with RPTOR. The GTP-bound form of RRAGA interacts with NOL8. Interacts with SH3BP4; the interaction with this
negative regulator is most probably direct, preferentially occurs with the inactive GDP-bound form of RRAGA and
is negatively regulated by amino acids. Interacts with adenovirus E3 14.7 kDa protein
Subcellular location: Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the
cytoplasm and nucleus, depending on the bound nucleotide state. Colocalizes in vivo with adenovirus E3-14.7K
mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane
Secondary accessions: B2R7L1 O00290 Q15347

Explore the universe of human proteins at neXtProt for RRAGA: NX_Q7L523

Explore proteomics data for RRAGA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7L523

  • RRAGA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RRAGA Protein Expression
    REFSEQ proteins: NP_006561.1  
    ENSEMBL proteins: 
     ENSP00000369899  

    Human Recombinant Protein Products for RRAGA: 
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    Novus Biologicals RRAGA Protein
    Novus Biologicals RRAGA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RRAGA 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11073942
    GO:0005737cytoplasm IDA11073942
    GO:0005764lysosome IDA--
    GO:0005765lysosomal membrane IDA17897319
    GO:0005794Golgi apparatus IDA--

    RRAGA for ontologies           About GeneDecksing



    RRAGA Antibody Products: 
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    ThermoFisher Antibody for RRAGA
    LSBio Antibodies in human, mouse, rat for RRAGA 

    Assay Products for RRAGA: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for RRAGA 
    Cloud-Clone Corp. CLIAs for RRAGA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR006762 Gtr1_RagA

    Graphical View of Domain Structure for InterPro Entry Q7L523

    ProtoNet protein and cluster: Q7L523

    UniProtKB/Swiss-Prot: RRAGA_HUMAN, Q7L523
    Similarity: Belongs to the GTR/RAG GTP-binding protein family


    RRAGA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RRAGA_HUMAN, Q7L523
    Function: Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino
    acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is
    a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase
    pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May
    alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby
    affecting cell death

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11073942
    GO:0005525GTP binding IDA14660641
    GO:0042803protein homodimerization activity IDA14660641
    GO:0046982protein heterodimerization activity IPI11073942
    GO:0051219phosphoprotein binding IDA8995684
         
    RRAGA for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RRAGA:
     Decreased cilium length after  

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rraga):
     cellular  growth/size  homeostasis/metabolism  mortality/aging 

    RRAGA for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RRAGA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RRAGA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RRAGA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RRAGA 

    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate RRAGA (see all 15):
    hsa-miR-3163 hsa-miR-586 hsa-miR-4255 hsa-miR-1271 hsa-miR-664 hsa-miR-3200-3p hsa-miR-182 hsa-miR-302f
    SwitchGear 3'UTR luciferase reporter plasmidRRAGA 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRAGA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RRAGA About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Translation Insulin regulation of translation
    mTOR signaling pathway0.34
    2Energy dependent regulation of mTOR by LKB1-AMPK
    TOR signaling0.33
    3Translational Control
    Translational Control

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for RRAGA
        Translational Control

    1 BioSystems Pathway for RRAGA
        TOR signaling



    1         Kegg Pathway  (Kegg details for RRAGA):
        mTOR signaling pathway


    RRAGA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RRAGA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/82 Interacting proteins for RRAGA (Q7L5231, 2, 3 ENSP000003698994) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RRAGDQ9NQL21, 3, ENSP000003584234EBI-752376,EBI-992949 I2D: score=6 STRING: ENSP00000358423
    RRAGCQ9HB901, 2, 3, ENSP000003620924EBI-752376,EBI-752390 MINT-68464 I2D: score=12 STRING: ENSP00000362092
    POLR1DQ9Y2S03, ENSP000003024784I2D: score=6 STRING: ENSP00000302478
    RPTORQ8N1223, ENSP000003072724I2D: score=3 STRING: ENSP00000307272
    CDC73Q6P1J93, ENSP000003564054I2D: score=1 STRING: ENSP00000356405
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007264small GTPase mediated signal transduction ----
    GO:0008219cell death IDA8995684
    GO:0019048modulation by virus of host morphology or physiology IDA8995684
    GO:0032008positive regulation of TOR signaling cascade NAS--

    RRAGA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RRAGA

    3 HMDB Compounds for RRAGA    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about RRAGA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RRAGA gene: 
    NM_006570.4  

    Unigene Cluster for RRAGA:

    Ras-related GTP binding A
    Hs.743260  [show with all ESTs]
    Unigene Representative Sequence: NM_006570
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000380527(uc003znj.3)
    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate RRAGA (see all 15):
    hsa-miR-3163 hsa-miR-586 hsa-miR-4255 hsa-miR-1271 hsa-miR-664 hsa-miR-3200-3p hsa-miR-182 hsa-miR-302f
    SwitchGear 3'UTR luciferase reporter plasmidRRAGA 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RRAGA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RRAGA
    Clone
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    GenScript: all cDNA clones in your preferred vector: RRAGA (NM_006570)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RRAGA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRAGA
    Sirion Biotech Customized lentivirus for stable overexpression of RRAGA 
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    Primer
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    OriGene qPCR primer pairs and template standards for RRAGA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RRAGA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RRAGA

    Additional mRNA sequence: 

    AK313023.1 BC006433.1 BC009990.2 U41654.1 X90529.1 

    16 DOTS entries:

    DT.75142641  DT.95245194  DT.100868161  DT.100868165  DT.121185923  DT.100868163  DT.95245186  DT.100868140 
    DT.121185897  DT.100868150  DT.121185895  DT.95245188  DT.95245196  DT.100703083  DT.100705909  DT.95245189 

    24/405 AceView cDNA sequences (see all 405):

    BM311887 AA890641 BU158008 CR602736 AA985490 CR594824 BQ271371 AA188306 
    CD172239 CR610906 CR602605 BU736913 CB528788 CK725017 CR612004 BM762944 
    AU126126 CR608617 NM_006570 CR626633 BM909968 CR623089 CR601089 CA776654 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RRAGA expression in normal human tissues (normalized intensities)      RRAGA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAACGTG
    RRAGA Expression
    About this image


    RRAGA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 14 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   

    See RRAGA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RRAGA

    SOURCE GeneReport for Unigene cluster: Hs.743260

    UniProtKB/Swiss-Prot: RRAGA_HUMAN, Q7L523
    Tissue specificity: Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain

        SABiosciences Expression via Pathway-Focused PCR Array including RRAGA: 
              mTOR Signaling in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRAGA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RRAGA gene from 8/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rraga1 , 5 Ras-related GTP binding A1, 5 92.76(n)1
    100(a)1
      4 (40.69 cM)5
    684411  NM_178376.31  NP_848463.11 
     865756685 
    chicken
    (Gallus gallus)
    Aves RRAGB1 Ras-related GTP binding B 84.13(n)
    99.36(a)
      422311  XM_420287.3  XP_420287.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    91(a)
    1 → many
    GL343577.1(237229-244340)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.37582 Xenopus laevis transcribed sequence with strong similarity to protein pirI38176 (H.sapiens) I38176 ras-related GTPase rag, splice form A [imported] - human less 82.88(n)    BX855374.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rraga1 Ras-related GTP binding A 79.23(n)
    96.17(a)
      325358  NM_199714.1  NP_956008.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RagA1 CG11968-PA 71.73(n)
    80.74(a)
      41071  NM_141593.3  NP_649850.1 
    worm
    (Caenorhabditis elegans)
    Secernentea raga-11 Protein RAGA-1 62.15(n)
    67.12(a)
      174726  NM_064014.6  NP_496415.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GTR16
    Cytoplasmic GTP binding protein and negative regul...
    52(a)
    1 → many
    XIII(26930-27862)


    ENSEMBL Gene Tree for RRAGA (if available)
    TreeFam Gene Tree for RRAGA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RRAGA gene
    RRAGB2  
    1 SIMAP similar gene for RRAGA using alignment to 1 protein entry:     RRAGA_HUMAN:
    RRAGB

    RRAGA for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RRAGA
    PGOHUM00000247790


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/125 SNPs in RRAGA are shown (see all 125)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs117883231,2
    H--19047372(+) aaaagA/Gaaaaa 1 -- us2k1 trp34Minor allele frequency- G:0.00NS EA 394
    rs1893514841,2
    C--19047402(+) CGTAAA/GATGTG 1 -- us2k10--------
    rs1432290731,2
    --19047471(+) TTCAAG/TAACAT 1 -- us2k10--------
    rs1175833631,2
    C,F--19047523(+) ATTGGA/GGAGTC 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs574822791,2
    C--19047573(+) ATTAA-/GTTTCA 1 -- us2k10--------
    rs109639301,2
    C,F,A--19047687(+) CAACAG/CAGCAA 1 -- us2k16Minor allele frequency- C:0.11NA WA EA 364
    rs1475193131,2
    --19047763(+) TTTTCA/GGACAT 1 -- us2k10--------
    rs1808446731,2
    C--19047812(+) TCTGGA/CAACTA 1 -- us2k10--------
    rs786829171,2
    C,F--19047897(+) AGAACG/CGGGAA 1 -- us2k11Minor allele frequency- C:0.02EA 120
    rs1856023111,2
    --19047933(+) GGCGAC/TCAGAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RRAGA (19049372 - 19051023 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RRAGA:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv892700CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612194    OMIM disorders: --

    2 diseases for RRAGA:    About MalaCards
    periodontal disease    periodontitis


    RRAGA for disorders           About GeneDecksing


    Export disorders for RRAGA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RRAGA gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with RRAGA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers. (PubMed id 8995684)1, 2, 3, 9 Li Y.... Horwitz M.S. (1997)
    2. Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagBl) with remote similarity to the Ras-related GTPases. (PubMed id 7499430)1, 2, 3 Schuermann A.... Joost H.-G. (1995)
    3. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. (PubMed id 18497260)1, 2 Sancak Y....Sabatini D.M. (2008)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D. (PubMed id 14660641)1, 2 Sekiguchi T....Nishimoto T. (2004)
    7. Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. (PubMed id 11073942)1, 2 Sekiguchi T.... Nishimoto T. (2001)
    8. RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway. (PubMed id 9394008)1, 2 Hirose E.... Nishimoto T. (1998)
    9. Microtubule-associated protein/microtubule affinity-re gulating kinase 4 (MARK4) is a negative regulator of the mammalian target of rap amycin complex 1 (mTORC1). (PubMed id 23184942)1 Li L. and Guan K.L. (2013)
    10. Cleavage and polyadenylation specificity factor 1 (CPS F1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. (PubMed id 23151878)1 Evsyukova I....Garcia-Blanco M.A. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10670 HGNC: 16963 AceView: RRAGA Ensembl:ENSG00000155876 euGenes: HUgn10670
    ECgene: RRAGA Kegg: 10670 H-InvDB: RRAGA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RRAGA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RRAGA gene:
    Search GeneIP for patents involving RRAGA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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