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Aliases for RRAGA Gene

Aliases for RRAGA Gene

  • Ras-Related GTP Binding A 2 3
  • RAGA 3 4 6
  • Adenovirus E3 14.7 KDa-Interacting Protein 1 3 4
  • Rag A 3 4
  • FIP-1 3 4
  • FIP1 3 6
  • Adenovirus E3-14.7K Interacting Protein 1 3
  • Ras-Related GTP-Binding Protein A 3

External Ids for RRAGA Gene

Summaries for RRAGA Gene

GeneCards Summary for RRAGA Gene

RRAGA (Ras-Related GTP Binding A) is a Protein Coding gene. Among its related pathways are Translational Control and Insulin receptor signalling cascade. GO annotations related to this gene include protein homodimerization activity and GTP binding. An important paralog of this gene is RRAGB.

UniProtKB/Swiss-Prot for RRAGA Gene

  • Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.

Gene Wiki entry for RRAGA Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRAGA Gene

Genomics for RRAGA Gene

Genomic Location for RRAGA Gene

Start:
19,049,374 bp from pter
End:
19,051,025 bp from pter
Size:
1,652 bases
Orientation:
Plus strand

Genomic View for RRAGA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RRAGA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRAGA Gene

Regulatory Elements for RRAGA Gene

Proteins for RRAGA Gene

  • Protein details for RRAGA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L523-RRAGA_HUMAN
    Recommended name:
    Ras-related GTP-binding protein A
    Protein Accession:
    Q7L523
    Secondary Accessions:
    • B2R7L1
    • O00290
    • Q15347

    Protein attributes for RRAGA Gene

    Size:
    313 amino acids
    Molecular mass:
    36566 Da
    Quaternary structure:
    • Can occur as a homodimer or as a heterodimer with RRAGC or RRAGD in a sequence-independent manner; heterodimerization stabilizes proteins of the heterodimer. In complex with RRAGC, but not with RRAGB, interacts with RPTOR. The GTP-bound form of RRAGA interacts with NOL8. Interacts with SH3BP4; the interaction with this negative regulator is most probably direct, preferentially occurs with the inactive GDP-bound form of RRAGA and is negatively regulated by amino acids. The Rag heterodimer interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906). Interacts with adenovirus E3 14.7 kDa protein.

neXtProt entry for RRAGA Gene

Proteomics data for RRAGA Gene at MOPED

Post-translational modifications for RRAGA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RRAGA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RRAGA Gene

Domains for RRAGA Gene

Protein Domains for RRAGA Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

RRAGA_HUMAN
Family:
  • Belongs to the GTR/RAG GTP-binding protein family.:
    • Q7L523
genes like me logo Genes that share domains with RRAGA: view

No data available for Gene Families for RRAGA Gene

Function for RRAGA Gene

Molecular function for RRAGA Gene

UniProtKB/Swiss-Prot Function: Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.

Gene Ontology (GO) - Molecular Function for RRAGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding IPI 11073942
GO:0005525 GTP binding IDA 14660641
GO:0042803 protein homodimerization activity IDA 14660641
GO:0046982 protein heterodimerization activity IPI 11073942
genes like me logo Genes that share ontologies with RRAGA: view
genes like me logo Genes that share phenotypes with RRAGA: view

miRNA for RRAGA Gene

miRTarBase miRNAs that target RRAGA

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RRAGA Gene

Localization for RRAGA Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRAGA Gene

Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state. Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RRAGA Gene COMPARTMENTS Subcellular localization image for RRAGA gene
Compartment Confidence
lysosome 5
nucleus 5
vacuole 5
golgi apparatus 4
mitochondrion 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RRAGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11073942
GO:0005737 cytoplasm IDA 11073942
GO:0005764 lysosome IDA 20381137
GO:0005765 lysosomal membrane IDA 17897319
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with RRAGA: view

Pathways for RRAGA Gene

genes like me logo Genes that share pathways with RRAGA: view

Pathways by source for RRAGA Gene

1 Cell Signaling Technology pathway for RRAGA Gene
1 BioSystems pathway for RRAGA Gene
1 KEGG pathway for RRAGA Gene

Gene Ontology (GO) - Biological Process for RRAGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007264 small GTPase mediated signal transduction --
GO:0008152 metabolic process IBA --
GO:0008219 cell death IDA 8995684
GO:0009267 cellular response to starvation IBA --
genes like me logo Genes that share ontologies with RRAGA: view

Compounds for RRAGA Gene

(3) HMDB Compounds for RRAGA Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with RRAGA: view

Transcripts for RRAGA Gene

mRNA/cDNA for RRAGA Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(405) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RRAGA Gene

Ras-related GTP binding A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RRAGA Gene

No ASD Table

Relevant External Links for RRAGA Gene

GeneLoc Exon Structure for
RRAGA
ECgene alternative splicing isoforms for
RRAGA

Expression for RRAGA Gene

mRNA expression in normal human tissues for RRAGA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RRAGA Gene

SOURCE GeneReport for Unigene cluster for RRAGA Gene Hs.743260

mRNA Expression by UniProt/SwissProt for RRAGA Gene

Q7L523-RRAGA_HUMAN
Tissue specificity: Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.
genes like me logo Genes that share expressions with RRAGA: view

Orthologs for RRAGA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RRAGA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RRAGA 36
  • 99.89 (n)
  • 100 (a)
RRAGA 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 97 (a)
OneToMany
-- 37
  • 99 (a)
OneToMany
RRAGA 36
  • 93.61 (n)
  • 100 (a)
RRAGA 37
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RRAGA 36
  • 92.44 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Rraga 36
  • 92.76 (n)
  • 100 (a)
Rraga 16
Rraga 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 88 (a)
ManyToMany
-- 37
  • 95 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Rraga 36
  • 92.55 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 87 (a)
OneToMany
RRAGB 36
  • 84.13 (n)
  • 99.36 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 91 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.3758 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rraga 36
  • 82.75 (n)
  • 98.08 (a)
Str.4849 36
zebrafish
(Danio rerio)
Actinopterygii rraga 36
  • 79.23 (n)
  • 96.17 (a)
rraga 37
  • 95 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta RagA 37
  • 77 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea raga-1 37
  • 63 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GTR1 37
  • 52 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gtr1 36
  • 58.7 (n)
  • 66.89 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6548 37
  • 73 (a)
OneToMany
Species with no ortholog for RRAGA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRAGA Gene

ENSEMBL:
Gene Tree for RRAGA (if available)
TreeFam:
Gene Tree for RRAGA (if available)

Paralogs for RRAGA Gene

Paralogs for RRAGA Gene

Selected SIMAP similar genes for RRAGA Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for RRAGA Gene

genes like me logo Genes that share paralogs with RRAGA: view

Variants for RRAGA Gene

Sequence variations from dbSNP and Humsavar for RRAGA Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs72696445 -- 19,051,474(+) TGCGT(A/G)CCTAC downstream-variant-500B
rs78956289 -- 19,051,441(+) AAAAA(A/T)TTTTT downstream-variant-500B
rs111851357 -- 19,051,442(+) AAAAA(A/T)TTTTT downstream-variant-500B
rs113732950 -- 19,051,426(+) CCCTC(C/T)CTCTA downstream-variant-500B
rs147533738 -- 19,051,454(+) TCATT(A/G)GCTAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RRAGA Gene

Variant ID Type Subtype PubMed ID
nsv892700 CNV Gain 21882294

Relevant External Links for RRAGA Gene

HapMap Linkage Disequilibrium report
RRAGA

Disorders for RRAGA Gene

No disorders were found for RRAGA Gene.

No data available for UniProtKB/Swiss-Prot for RRAGA Gene

Publications for RRAGA Gene

  1. Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers. (PMID: 8995684) Li Y. … Horwitz M.S. (J. Virol. 1997) 2 3 4 23
  2. Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagBl) with remote similarity to the Ras-related GTPases. (PMID: 7499430) Schuermann A. … Joost H.-G. (J. Biol. Chem. 1995) 2 3 4
  3. RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway. (PMID: 9394008) Hirose E. … Nishimoto T. (J. Cell Sci. 1998) 3 4
  4. Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. (PMID: 11073942) Sekiguchi T. … Nishimoto T. (J. Biol. Chem. 2001) 3 4
  5. A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D. (PMID: 14660641) Sekiguchi T. … Nishimoto T. (J. Biol. Chem. 2004) 3 4

Products for RRAGA Gene

  • Addgene plasmids for RRAGA

Sources for RRAGA Gene

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