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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RRAGA Gene

protein-coding GIFtS: 53
GCID: GC09P019049

Ras-related GTP binding A

Explore 2 diseases affiliated with
RRAGA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ras-Related GTP Binding A¹ ²		FIP1² ⁵
FIP-1¹ ² ³		Adenovirus E3-14.7K Interacting Protein 1²
RAGA¹ ² ⁵		Ras-Related GTP-Binding Protein A²
Adenovirus E3 14.7 KDa-Interacting Protein 1² ³		RagA³
Rag A² ³

External Ids:	HGNC: 16963¹	Entrez Gene: 10670²	Ensembl: ENSG00000155876⁷	OMIM: 612194⁵	UniProtKB: Q7L523³

Export aliases for RRAGA gene to outside databases

Previous GC identifers: GC09P019039 GC09P019010

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RRAGA_HUMAN, Q7L523

Function: Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino

acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a

crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway.

May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a

cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death

Gene Wiki entry for RRAGA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008413.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RRAGA gene promoter:
STAT1 AML1a Brachyury CUTL1 Arnt RORalpha1 TFIID IRF-7A Zic3 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RRAGA promoter sequence

Search SABiosciences Chromatin IP Primers for RRAGA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RRAGA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22.1 Ensembl cytogenetic band: 9p22.1 HGNC cytogenetic band: 9p21.3

RRAGA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RRAGA gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P019049: view genomic region (about GC identifiers)

Start:	19,049,372 bp from pter	End:	19,051,023 bp from pter
Size:	1,652 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RRAGA_HUMAN, Q7L523 (See protein sequence)

Recommended Name: Ras-related GTP-binding protein A

Size: 313 amino acids; 36566 Da

Subunit: Binds GTP. Can occur as a homodimer or as a heterodimer with RRAGC or RRAGD in a sequence-independent manner;

heterodimerization stabilizes PPAG proteins. In complex with RRAGC, but not with RRAGB, interacts with RPTOR. The

GTP-bound form of RRAGA interacts with NOL8. Interacts with adenovirus E3 14.7 kDa protein

Subcellular location: Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm

and nucleus, depending on the bound nucleotide state. Colocalizes in vivo with adenovirus E3-14.7K mainly to the

cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane

Secondary accessions: B2R7L1 O00290 Q15347

Explore the universe of human proteins at neXtProt for RRAGA: NX_Q7L523

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q7L523

RRAGA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006561.1

ENSEMBL proteins:

ENSP00000369899

Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RRAGA

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	8995684
GO:0005737	cytoplasm	IDA	9394008
GO:0005764	lysosome	IDA	--
GO:0005794	Golgi apparatus	IDA	--
GO:0043231	intracellular membrane-bounded organelle	IDA	--

RRAGA for ontologies About GeneDecksing

RRAGA Antibody Products:

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	Uscn ELISAs and CLIAs for RRAGA

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RRAGA for domains About GeneDecksing

1 InterPro domain/family:

IPR006762 Gtr1_RagA

Graphical View of Domain Structure for InterPro Entry Q7L523

ProtoNet protein and cluster: Q7L523

UniProtKB/Swiss-Prot: RRAGA_HUMAN, Q7L523

Similarity: Belongs to the GTR/RAG GTP-binding protein family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RRAGA_HUMAN, Q7L523

Function: Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino

acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a

crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway.

May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a

cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death

miRNA Products:		OriGene 3'-UTR Clone: RRAGA Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RRAGA
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate RRAGA (see all 15):
		hsa-miR-3163 hsa-miR-586 hsa-miR-4255 hsa-miR-1271 hsa-miR-664 hsa-miR-3200-3p hsa-miR-182 hsa-miR-302f

		SwitchGear 3'UTR luciferase reporter plasmid: RRAGA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RRAGA (see all 7) OriGene shRNA RFP: RRAGA OriGene siRNA: RRAGA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RRAGA

Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RRAGA
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRAGA

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0005525	GTP binding	IDA	14660641
GO:0042803	protein homodimerization activity	IDA	14660641
GO:0046982	protein heterodimerization activity	IPI	14660641
GO:0051219	phosphoprotein binding	IDA	8995684

RRAGA for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for RRAGA:

Decreased cilium length after

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Translational Control

Translational Control

1.00

mTOR signalling

TOR signaling

0.33

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for RRAGA

Translational Control

1 BioSystems Pathway for RRAGA

TOR signaling

RRAGA for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RRAGA

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/82 Interacting proteins for RRAGA (Q7L523^{1, 2, 3} ENSP00000369899⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 82)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RRAGD	Q9NQL2¹^,³, ENSP00000358423⁴	EBI-752376,EBI-992949 I2D: score=6 STRING: ENSP00000358423
RRAGC	Q9HB90¹^,²^,³, ENSP00000362092⁴	EBI-752376,EBI-752390 MINT-68464 I2D: score=12 STRING: ENSP00000362092
POLR1D	Q9Y2S0³, ENSP00000302478⁴	I2D: score=6 STRING: ENSP00000302478
RPTOR	Q8N122³, ENSP00000307272⁴	I2D: score=3 STRING: ENSP00000307272
CDC73	Q6P1J9³, ENSP00000356405⁴	I2D: score=1 STRING: ENSP00000356405

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	IEA	--
GO:0008219	cell death	IDA	9394008
GO:0019048	virus-host interaction	IDA	8995684
GO:0032008	positive regulation of TOR signaling cascade	NAS	--
GO:0034613	cellular protein localization	IMP	--

RRAGA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RRAGA

3 HMDB Compounds for RRAGA About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about RRAGA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RRAGA gene:

NM_006570.4

Unigene Cluster for RRAGA:

Ras-related GTP binding A

Hs.743260 [show with all ESTs]

Unigene Representative Sequence: NM_006570

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000380527(uc003znj.3)

miRNA Products:		OriGene 3'-UTR Clone: RRAGA Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RRAGA
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate RRAGA (see all 15):
		hsa-miR-3163 hsa-miR-586 hsa-miR-4255 hsa-miR-1271 hsa-miR-664 hsa-miR-3200-3p hsa-miR-182 hsa-miR-302f

		SwitchGear 3'UTR luciferase reporter plasmid: RRAGA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RRAGA (see all 7) OriGene shRNA RFP: RRAGA OriGene siRNA: RRAGA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RRAGA

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RRAGA (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RRAGA OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RRAGA (NM_006570)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RRAGA

Additional cDNA sequence:

AK313023.1 BC006433.1 BC009990.2 U41654.1 X90529.1

16 DOTS entries:

DT.75142641 DT.95245194 DT.100868161 DT.100868165 DT.121185923 DT.100868163 DT.95245186 DT.100868140

DT.121185897 DT.100868150 DT.121185895 DT.95245188 DT.95245196 DT.100703083 DT.100705909 DT.95245189

24/405 AceView cDNA sequences (see all 405):

BM311887 CR626633 CR594824 CR623089 AI589309 CD369419 CD172239 AA188306

AU126126 CR602698 AA985490 BX366141 AA193306 CA776654 BX408513 AA890641

CR601089 CR610906 CR626305 BM909968 AI263470 BF724426 AA338505 BQ271371

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RRAGA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATAAACGTG

About this image
See RRAGA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RRAGA

SOURCE GeneReport for Unigene cluster: Hs.743260

UniProtKB/Swiss-Prot: RRAGA_HUMAN, Q7L523

Tissue specificity: Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain

SABiosciences Expression via Pathway-Focused PCR Array including RRAGA:

mTOR Signaling in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRAGA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RRAGA gene from 6/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Rraga^{1 , 5}	Ras-related GTP binding A^{1, 5}	92.76(n)¹ 100(a)¹	4 (40.69 cM)⁵ 68441¹ NM_178376.3¹ NP_848463.1¹ 86575668⁵
chicken (Gallus gallus)	Aves	RRAGB¹	Ras-related GTP binding B	84.13(n) 99.36(a)	422311 XM_420287.3 XP_420287.1
African clawed frog (Xenopus laevis)	Amphibia	Xl.3758²	Xenopus laevis transcribed sequence with strong similarity more	82.88(n)	BX855374.1
zebrafish (Danio rerio)	Actinopterygii	rraga¹	Ras-related GTP binding A	79.23(n) 96.17(a)	325358 NM_199714.1 NP_956008.1
fruit fly (Drosophila melanogaster)	Insecta	RagA¹	CG11968-PA	71.73(n) 80.74(a)	41071 NM_141593.3 NP_649850.1
worm (Caenorhabditis elegans)	Secernentea	raga-1¹	Protein RAGA-1	62.15(n) 67.12(a)	174726 NM_064014.6 NP_496415.1

ENSEMBL Gene Tree for RRAGA (if available)
TreeFam Gene Tree for RRAGA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RRAGA gene

RRAGB²

1 SIMAP similar gene for RRAGA using alignment to 1 protein entry: RRAGA_HUMAN:

RRAGB

RRAGA for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for RRAGA
PGOHUM00000247790

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11788323^1,2	H	--	19047372(+)	`aaaagA/Gaaaaa`	1	--	us2k¹ trp³		4		NS EA	394
rs189351484^1,2		--	19047402(+)	`CGTAAA/GATGTG`	1	--	us2k¹		0	--	--	--	--
rs143229073^1,2		--	19047471(+)	`TTCAAG/TAACAT`	1	--	us2k¹		0	--	--	--	--
rs117583363^1,2		--	19047523(+)	`ATTGGA/GGAGTC`	1	--	us2k¹		1		NA	120
rs57482279^1,2	C,	--	19047573(+)	`ATTAA-/GTTTCA`	1	--	us2k¹		0	--	--	--	--
rs10963930^1,2	C,F,A,	--	19047687(+)	`CAACAG/CAGCAA`	1	--	us2k¹		6		NA WA EA	364
rs147519313^1,2		--	19047763(+)	`TTTTCA/GGACAT`	1	--	us2k¹		0	--	--	--	--
rs180844673^1,2		--	19047812(+)	`TCTGGA/CAACTA`	1	--	us2k¹		0	--	--	--	--
rs78682917^1,2	C,F,	--	19047897(+)	`AGAACG/CGGGAA`	1	--	us2k¹		1		EA	120
rs185602311^1,2		--	19047933(+)	`GGCGAC/TCAGAT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RRAGA (19049372 - 19051023 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RRAGA
1 CNV: 52762

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RRAGA

DNA2.0 Custom Variant and Variant Library Synthesis for RRAGA

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RRAGA for disorders           About GeneDecksing

OMIM gene information: 612194    OMIM disorders: --

2 diseases for RRAGA:    About MalaCards

periodontitis periodontal disease

Export disorders for RRAGA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RRAGA gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with RRAGA)

Utopia: connect your pdf to the dynamic
world of online information

Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers. (PubMed id 8995684)^{1, 2, 3, 9} Li Y.... Horwitz M.S. (1997)
Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagBl) with remote similarity to the Ras-related GTPases. (PubMed id 7499430)^{1, 2, 3} Schuermann A.... Joost H.-G. (1995)
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. (PubMed id 18497260)^{1, 2} Sancak Y....Sabatini D.M. (2008)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D. (PubMed id 14660641)^{1, 2} Sekiguchi T....Nishimoto T. (2004)
Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. (PubMed id 11073942)^{1, 2} Sekiguchi T.... Nishimoto T. (2001)
RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway. (PubMed id 9394008)^{1, 2} Hirose E.... Nishimoto T. (1998)
p62 is a key regulator of nutrient sensing in the mTO RC1 pathway. (PubMed id 21981924)¹ Duran A....Diaz-Meco M.T. (2011)
Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation. (PubMed id 21816923)¹ Gong R....Xu Y. (2011)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10670	HGNC: 16963	AceView: RRAGA	Ensembl:ENSG00000155876	euGenes: HUgn10670
ECgene: RRAGA	H-InvDB: RRAGA

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RRAGA	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RRAGA gene
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Patent Information for RRAGA gene:
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