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Aliases for RRAGA Gene

Aliases for RRAGA Gene

  • Ras Related GTP Binding A 2 3
  • Ras-Related GTP Binding A 2 3 5
  • Adenovirus E3 14.7 KDa-Interacting Protein 1 3 4
  • Rag A 3 4
  • FIP-1 3 4
  • RAGA 3 4
  • Adenovirus E3-14.7K Interacting Protein 1 3
  • FIP1 3

External Ids for RRAGA Gene

Previous GeneCards Identifiers for RRAGA Gene

  • GC09P019039
  • GC09P019010

Summaries for RRAGA Gene

GeneCards Summary for RRAGA Gene

RRAGA (Ras Related GTP Binding A) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include protein homodimerization activity and GTP binding. An important paralog of this gene is RRAGB.

UniProtKB/Swiss-Prot for RRAGA Gene

  • Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates to the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.

Gene Wiki entry for RRAGA Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRAGA Gene

Genomics for RRAGA Gene

Regulatory Elements for RRAGA Gene

Promoters for RRAGA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RRAGA on UCSC Golden Path with GeneCards custom track

Genomic Location for RRAGA Gene

Chromosome:
9
Start:
19,049,374 bp from pter
End:
19,051,025 bp from pter
Size:
1,652 bases
Orientation:
Plus strand

Genomic View for RRAGA Gene

Genes around RRAGA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRAGA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRAGA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRAGA Gene

Proteins for RRAGA Gene

  • Protein details for RRAGA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L523-RRAGA_HUMAN
    Recommended name:
    Ras-related GTP-binding protein A
    Protein Accession:
    Q7L523
    Secondary Accessions:
    • B2R7L1
    • O00290
    • Q15347

    Protein attributes for RRAGA Gene

    Size:
    313 amino acids
    Molecular mass:
    36566 Da
    Quaternary structure:
    • Can occur as a homodimer or as a heterodimer with RRAGC or RRAGD in a sequence-independent manner; heterodimerization stabilizes proteins of the heterodimer (PubMed:11073942, PubMed:20381137). In complex with RRAGC, but not with RRAGB, interacts with RPTOR (PubMed:18497260). The GTP-bound form of RRAGA interacts with NOL8 (PubMed:14660641). Interacts with SH3BP4; the interaction with this negative regulator is most probably direct, preferentially occurs with the inactive GDP-bound form of RRAGA and is negatively regulated by amino acids (PubMed:22575674). The Rag heterodimer interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906). Interacts (inactive GDP-bound form) with RNF152; stimulated by amino acid starvation (PubMed:25936802). Interacts (polyubiquitinated) with the GATOR1 complex; inactivates RRAGA (PubMed:25936802). Interacts (polyubiquitinated) with TSC2 (PubMed:25936802). Interacts with adenovirus E3 14.7 kDa protein (PubMed:8995684).

neXtProt entry for RRAGA Gene

Proteomics data for RRAGA Gene at MOPED

Post-translational modifications for RRAGA Gene

  • Ubiquitinated. Lys-68-linked polyubiquitination of the GDP-bound inactive form of RRAGA by RNF152 is increased in response to amino acid starvation. Polyubiquitination promotes interaction with the GATOR1 complex. This does not affect RRAGA degradation.
  • Ubiquitination at Lys 142, Lys 220, Lys 230, and Lys 244
  • Modification sites at PhosphoSitePlus

Other Protein References for RRAGA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RRAGA (RRAGA)

No data available for DME Specific Peptides for RRAGA Gene

Domains & Families for RRAGA Gene

Protein Domains for RRAGA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RRAGA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L523

UniProtKB/Swiss-Prot:

RRAGA_HUMAN :
  • Belongs to the GTR/RAG GTP-binding protein family.
Family:
  • Belongs to the GTR/RAG GTP-binding protein family.
genes like me logo Genes that share domains with RRAGA: view

No data available for Gene Families for RRAGA Gene

Function for RRAGA Gene

Molecular function for RRAGA Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
The activation of GTP-binding proteins is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP) (PubMed:25936802). The GATOR1 complex functions as a GAP and stimulates RRAGA GTPase activity to turn it into its inactive GDP-bound form (PubMed:25936802, PubMed:23723238).
UniProtKB/Swiss-Prot Function:
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates to the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.
genes like me logo Genes that share phenotypes with RRAGA: view

Animal Model Products

miRNA for RRAGA Gene

miRTarBase miRNAs that target RRAGA

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRAGA Gene

Localization for RRAGA Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRAGA Gene

Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state (PubMed:8995684, PubMed:9394008). Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane (PubMed:8995684). {ECO:0000269 PubMed:20381137, ECO:0000269 PubMed:8995684, ECO:0000269 PubMed:9394008}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RRAGA Gene COMPARTMENTS Subcellular localization image for RRAGA gene
Compartment Confidence
cytosol 5
golgi apparatus 5
lysosome 5
nucleus 5
vacuole 5
mitochondrion 2
endosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RRAGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1990131 Gtr1-Gtr2 GTPase complex IBA --
genes like me logo Genes that share ontologies with RRAGA: view

Pathways & Interactions for RRAGA Gene

genes like me logo Genes that share pathways with RRAGA: view

Pathways by source for RRAGA Gene

1 KEGG pathway for RRAGA Gene

Gene Ontology (GO) - Biological Process for RRAGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006915 apoptotic process IEA --
GO:0008219 cell death IDA 8995684
GO:0008286 insulin receptor signaling pathway TAS --
GO:0010507 negative regulation of autophagy IMP 25936802
genes like me logo Genes that share ontologies with RRAGA: view

No data available for SIGNOR curated interactions for RRAGA Gene

Drugs & Compounds for RRAGA Gene

(3) Drugs for RRAGA Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RRAGA: view

Transcripts for RRAGA Gene

mRNA/cDNA for RRAGA Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(405) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RRAGA Gene

Ras-related GTP binding A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RRAGA Gene

No ASD Table

Relevant External Links for RRAGA Gene

GeneLoc Exon Structure for
RRAGA
ECgene alternative splicing isoforms for
RRAGA

Expression for RRAGA Gene

mRNA expression in normal human tissues for RRAGA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RRAGA Gene

This gene is overexpressed in Heart (15.4) and Peripheral blood mononuclear cells (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RRAGA Gene



SOURCE GeneReport for Unigene cluster for RRAGA Gene Hs.743260

mRNA Expression by UniProt/SwissProt for RRAGA Gene

Q7L523-RRAGA_HUMAN
Tissue specificity: Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.
genes like me logo Genes that share expression patterns with RRAGA: view

Protein tissue co-expression partners for RRAGA Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RRAGA Gene

Orthologs for RRAGA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RRAGA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RRAGA 35
  • 99.89 (n)
  • 100 (a)
RRAGA 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 97 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
RRAGA 36
  • 100 (a)
OneToMany
RRAGA 35
  • 93.61 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia RRAGA 35
  • 92.44 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Rraga 36
  • 100 (a)
OneToOne
Rraga 16
Rraga 35
  • 92.76 (n)
  • 100 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
ManyToMany
-- 36
  • 95 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Rraga 35
  • 92.55 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 87 (a)
OneToMany
RRAGB 35
  • 84.13 (n)
  • 99.36 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 91 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.3758 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rraga 35
  • 82.75 (n)
  • 98.08 (a)
Str.4849 35
zebrafish
(Danio rerio)
Actinopterygii rraga 36
  • 95 (a)
OneToMany
rraga 35
  • 79.23 (n)
  • 96.17 (a)
fruit fly
(Drosophila melanogaster)
Insecta RagA 36
  • 77 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea raga-1 36
  • 63 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GTR1 36
  • 52 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gtr1 35
  • 58.7 (n)
  • 66.89 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6548 36
  • 73 (a)
OneToMany
Species with no ortholog for RRAGA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRAGA Gene

ENSEMBL:
Gene Tree for RRAGA (if available)
TreeFam:
Gene Tree for RRAGA (if available)

Paralogs for RRAGA Gene

Paralogs for RRAGA Gene

(1) SIMAP similar genes for RRAGA Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for RRAGA Gene

genes like me logo Genes that share paralogs with RRAGA: view

Variants for RRAGA Gene

Sequence variations from dbSNP and Humsavar for RRAGA Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs72696445 -- 19,051,474(+) TGCGT(A/G)CCTAC downstream-variant-500B
rs113732950 -- 19,051,426(+) CCCTC(C/T)CTCTA downstream-variant-500B
rs111851357 -- 19,051,442(+) AAAAA(A/T)TTTTT downstream-variant-500B
rs147533738 -- 19,051,454(+) TCATT(A/G)GCTAG downstream-variant-500B
rs191777698 -- 19,051,512(+) GAGAG(C/G)ATTGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RRAGA Gene

Variant ID Type Subtype PubMed ID
nsv892700 CNV Gain 21882294

Variation tolerance for RRAGA Gene

Residual Variation Intolerance Score: 24.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRAGA Gene

HapMap Linkage Disequilibrium report
RRAGA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRAGA Gene

Disorders for RRAGA Gene

Relevant External Links for RRAGA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RRAGA

No disorders were found for RRAGA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRAGA Gene

Publications for RRAGA Gene

  1. Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers. (PMID: 8995684) Li Y. … Horwitz M.S. (J. Virol. 1997) 2 3 4 23 67
  2. Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagBl) with remote similarity to the Ras-related GTPases. (PMID: 7499430) Schuermann A. … Joost H.-G. (J. Biol. Chem. 1995) 2 3
  3. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. (PMID: 25561175) Rebsamen M. … Superti-Furga G. (Nature 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1. (PMID: 26051179) Jin G. … Lin H.K. (Mol. Cell 2015) 3

Products for RRAGA Gene

Sources for RRAGA Gene

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