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Aliases for RRAD Gene

Aliases for RRAD Gene

  • RRAD, Ras Related Glycolysis Inhibitor And Calcium Channel Regulator 2 3 5
  • RRAD, Ras Related Glycolysis Inihibitor And Calcium Channel Regulator 2 3
  • Ras-Related Associated With Diabetes 2 3
  • Ras Associated With Diabetes 3 4
  • RAD1 3 4
  • RAD 3 4
  • RAS (RAD And GEM) Like GTP Binding 3 3
  • GTP-Binding Protein RAD 3
  • REM3 3

External Ids for RRAD Gene

Previous GeneCards Identifiers for RRAD Gene

  • GC16M057650
  • GC16M067333
  • GC16M066691
  • GC16M066731
  • GC16M065513
  • GC16M066955
  • GC16M052829

Summaries for RRAD Gene

GeneCards Summary for RRAD Gene

RRAD (RRAD, Ras Related Glycolysis Inhibitor And Calcium Channel Regulator) is a Protein Coding gene. Among its related pathways are Angiopoietin Like Protein 8 Regulatory Pathway. GO annotations related to this gene include GTP binding and calmodulin binding. An important paralog of this gene is GEM.

UniProtKB/Swiss-Prot for RRAD Gene

  • May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.

Gene Wiki entry for RRAD Gene

Additional gene information for RRAD Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRAD Gene

Genomics for RRAD Gene

Regulatory Elements for RRAD Gene

Enhancers for RRAD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H066902 2.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 15.4 +21.1 21104 4 PKNOX1 FOXA2 MLX ARNT ARID4B DMAP1 ZNF2 ATF7 SP5 NFYC CES2 KIAA0895L E2F4 NAE1 RRAD FAM96B EDC4 CENPT CTCF EXOC3L1
GH16H066899 1.6 Ensembl ENCODE dbSUPER 13.4 +24.9 24917 3 HDGF FOXA2 ARNT ZNF766 REST ZNF592 KAT8 MEF2D SSRP1 ZNF610 CES2 CTCF E2F4 FBXL8 TRADD ZDHHC1 ENSG00000260465 RRAD FAM96B ENKD1
GH16H066977 1.5 Ensembl ENCODE dbSUPER 10.7 -52.2 -52157 0 HDGF ARID4B SIN3A ZNF2 SLC30A9 GLIS2 ZNF143 RUNX3 DEK SP5 CES2 ELMO3 CBFB B3GNT9 FBXL8 TRADD HSF4 C16orf70 RRAD CDH16
GH16H066894 1.2 Ensembl ENCODE 12.6 +30.4 30411 0 HDGF RB1 ARID4B KLF17 ZNF2 RAD21 RFX5 ZNF143 ATF7 RUNX3 CES2 CDH16 RRAD FAM96B FBXL8 HSF4 TRADD GC16P066890 GC16P066912 GC16P066911
GH16H066960 1.2 Ensembl ENCODE 11.6 -35.5 -35477 1 HDGF PKNOX1 ARNT ARID4B ZNF2 ZNF143 ATF7 DEK REST MIER2 FBXL8 TRADD HSF4 CES2 RRAD CDH16 FAM96B B3GNT9 CBFB MIR328
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RRAD on UCSC Golden Path with GeneCards custom track

Promoters for RRAD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000087032 544 201 ELF3 CTCF RB1 SUZ12 RAD21 TEAD3 CTBP1 ZNF143 ATF7 EZH2

Transcription factor binding sites by QIAGEN in the RRAD gene promoter:

Genomic Location for RRAD Gene

Chromosome:
16
Start:
66,921,679 bp from pter
End:
66,925,644 bp from pter
Size:
3,966 bases
Orientation:
Minus strand

Genomic View for RRAD Gene

Genes around RRAD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRAD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRAD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRAD Gene

Proteins for RRAD Gene

  • Protein details for RRAD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55042-RAD_HUMAN
    Recommended name:
    GTP-binding protein RAD
    Protein Accession:
    P55042
    Secondary Accessions:
    • Q96F39

    Protein attributes for RRAD Gene

    Size:
    308 amino acids
    Molecular mass:
    33245 Da
    Quaternary structure:
    • Interacts with calmodulin preferentially in the inactive, GDP-bound form. Binds CAMKII which is capable of phosphorylating RAD in vitro. Interacts with CAMK2D and CACNB2. Interaction with CACNB2 regulates the trafficking of CACNA1C to the cell membrane (By similarity).

    Three dimensional structures from OCA and Proteopedia for RRAD Gene

neXtProt entry for RRAD Gene

Post-translational modifications for RRAD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RRAD Gene

No data available for DME Specific Peptides for RRAD Gene

Domains & Families for RRAD Gene

Gene Families for RRAD Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RRAD Gene

Suggested Antigen Peptide Sequences for RRAD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55042

UniProtKB/Swiss-Prot:

RAD_HUMAN :
  • Belongs to the small GTPase superfamily. RGK family.
Family:
  • Belongs to the small GTPase superfamily. RGK family.
genes like me logo Genes that share domains with RRAD: view

Function for RRAD Gene

Molecular function for RRAD Gene

GENATLAS Biochemistry:
Ras-GTPase activating protein family member,with high homology to GEM,overexpressed in non-insulin dependent diabetes mellitus (increasing insulin resistant)
UniProtKB/Swiss-Prot Function:
May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.
UniProtKB/Swiss-Prot Induction:
Down-regulated in failing hearts.

Gene Ontology (GO) - Molecular Function for RRAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS,IEA --
GO:0005515 protein binding IPI 10359610
GO:0005516 calmodulin binding IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RRAD: view
genes like me logo Genes that share phenotypes with RRAD: view

Animal Models for RRAD Gene

MGI Knock Outs for RRAD:

Animal Model Products

CRISPR Products

miRNA for RRAD Gene

miRTarBase miRNAs that target RRAD

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RRAD
  • Applied Biological Materials Clones for RRAD
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RRAD Gene

Localization for RRAD Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRAD Gene

Cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRAD gene
Compartment Confidence
plasma membrane 4
nucleus 3
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RRAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RRAD: view

Pathways & Interactions for RRAD Gene

genes like me logo Genes that share pathways with RRAD: view

Pathways by source for RRAD Gene

1 BioSystems pathway for RRAD Gene

Gene Ontology (GO) - Biological Process for RRAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction TAS 8248782
GO:1901841 regulation of high voltage-gated calcium channel activity IEA --
GO:1901842 negative regulation of high voltage-gated calcium channel activity IEA --
genes like me logo Genes that share ontologies with RRAD: view

No data available for SIGNOR curated interactions for RRAD Gene

Drugs & Compounds for RRAD Gene

(4) Drugs for RRAD Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for RRAD Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RRAD: view

Transcripts for RRAD Gene

Unigene Clusters for RRAD Gene

Ras-related associated with diabetes:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RRAD
  • Applied Biological Materials Clones for RRAD
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RRAD Gene

No ASD Table

Relevant External Links for RRAD Gene

GeneLoc Exon Structure for
RRAD
ECgene alternative splicing isoforms for
RRAD

Expression for RRAD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RRAD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RRAD Gene

This gene is overexpressed in Muscle - Skeletal (x16.2), Heart - Left Ventricle (x6.8), and Heart - Atrial Appendage (x6.8).

Protein differential expression in normal tissues from HIPED for RRAD Gene

This gene is overexpressed in Gallbladder (23.7) and Fetal heart (18.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RRAD Gene



Protein tissue co-expression partners for RRAD Gene

NURSA nuclear receptor signaling pathways regulating expression of RRAD Gene:

RRAD

SOURCE GeneReport for Unigene cluster for RRAD Gene:

Hs.1027

mRNA Expression by UniProt/SwissProt for RRAD Gene:

P55042-RAD_HUMAN
Tissue specificity: Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.

Evidence on tissue expression from TISSUES for RRAD Gene

  • Muscle(4.7)
  • Eye(4.2)
  • Heart(2.6)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with RRAD: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RRAD Gene

Orthologs for RRAD Gene

This gene was present in the common ancestor of animals.

Orthologs for RRAD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RRAD 33 34
  • 99.24 (n)
cow
(Bos Taurus)
Mammalia RRAD 33 34
  • 89.28 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RRAD 34
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RRAD 33 34
  • 86.64 (n)
mouse
(Mus musculus)
Mammalia Rrad 33 16 34
  • 85.8 (n)
rat
(Rattus norvegicus)
Mammalia Rrad 33
  • 85.68 (n)
oppossum
(Monodelphis domestica)
Mammalia RRAD 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves RRAD 33 34
  • 70.02 (n)
lizard
(Anolis carolinensis)
Reptilia RRAD 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rrad 33
  • 64 (n)
Str.9633 33
zebrafish
(Danio rerio)
Actinopterygii rrad 33 34
  • 68.18 (n)
wufi06a10 33
fruit fly
(Drosophila melanogaster)
Insecta Rgk3 34
  • 19 (a)
ManyToMany
Rgk1 34
  • 18 (a)
ManyToMany
Rgk2 34
  • 12 (a)
ManyToMany
CG42541 34
  • 7 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y52B11A.4 34
  • 16 (a)
OneToMany
Species where no ortholog for RRAD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRAD Gene

ENSEMBL:
Gene Tree for RRAD (if available)
TreeFam:
Gene Tree for RRAD (if available)

Paralogs for RRAD Gene

Paralogs for RRAD Gene

(15) SIMAP similar genes for RRAD Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RRAD: view

Variants for RRAD Gene

Sequence variations from dbSNP and Humsavar for RRAD Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000102227 -- 66,925,130(+) CCTGG(A/C)CCCCA reference, missense
rs1001046979 -- 66,925,280(+) GGCGG(C/G)ATGCT intron-variant
rs1001060859 -- 66,925,086(+) CGGGG(C/G)GGGGC reference, missense
rs1001097382 -- 66,925,574(+) CCACC(A/C)GCCCC upstream-variant-2KB
rs1001121002 -- 66,924,659(+) AAACT(C/G)TGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RRAD Gene

Variant ID Type Subtype PubMed ID
nsv572904 CNV loss 21841781
nsv827706 CNV loss 20364138

Variation tolerance for RRAD Gene

Residual Variation Intolerance Score: 33.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRAD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RRAD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRAD Gene

Disorders for RRAD Gene

Relevant External Links for RRAD

Genetic Association Database (GAD)
RRAD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RRAD

No disorders were found for RRAD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RRAD Gene

Publications for RRAD Gene

  1. Rad GTPase deficiency leads to cardiac hypertrophy. (PMID: 18056528) Chang L … Chen YE (Circulation 2007) 3 4 22 60
  2. Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II. (PMID: 9115241) Moyers JS … Kahn CR (The Journal of biological chemistry 1997) 3 4 22 60
  3. RRAD inhibits aerobic glycolysis, invasion, and migration and is associated with poor prognosis in hepatocellular carcinoma. (PMID: 26546438) Shang R … Wang D (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 2 3 60
  4. Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD. (PMID: 25114038) Zhang C … Feng Z (Oncotarget 2014) 2 3 60
  5. Ancient origins of RGK protein function: modulation of voltage-gated calcium channels preceded the protostome and deuterostome split. (PMID: 24992013) Puhl HL … Ikeda SR (PloS one 2014) 2 3 60

Products for RRAD Gene

  • Addgene plasmids for RRAD

Sources for RRAD Gene

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