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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RRAD Gene

protein-coding   GIFtS: 55
GCID: GC16M066955

Ras-Related Associated With Diabetes

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ras-Related Associated With Diabetes1 2     REM32
Ras Associated With Diabetes2 3     GTP-Binding Protein RAD2
RAD2 3     RAS (RAD And GEM) Like GTP Binding 32
RAD12 3     

External Ids:    HGNC: 104461   Entrez Gene: 62362   Ensembl: ENSG000001665927   OMIM: 1795035   UniProtKB: P550423   

Export aliases for RRAD gene to outside databases

Previous GC identifers: GC16M057650 GC16M067333 GC16M066691 GC16M066731 GC16M065513 GC16M052829


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RRAD Gene: 
RRAD (Ras-related associated with diabetes) is a protein-coding gene. Diseases associated with RRAD include hepatic angiomyolipoma, and skeletal muscle regeneration. GO annotations related to this gene include calmodulin binding and GTP binding. An important paralog of this gene is REM2.

UniProtKB/Swiss-Prot: RAD_HUMAN, P55042
Function: May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type
Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell
membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII)
pathway. Inhibits phosphorylation and activation of CAMK2D

Gene Wiki entry for RRAD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RRAD gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRRAD promoter sequence
   Search SABiosciences Chromatin IP Primers for RRAD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RRAD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22

RRAD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RRAD gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M066955:  view genomic region     (about GC identifiers)

Start:
66,955,582 bp from pter      End:
66,959,547 bp from pter
Size:
3,966 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RAD_HUMAN, P55042 (See protein sequence)
Recommended Name: GTP-binding protein RAD  
Size: 308 amino acids; 33245 Da
Subunit: Interacts with calmodulin preferentially in the inactive, GDP-bound form. Binds CAMKII which is capable
of phosphorylating RAD in vitro. Interacts with CAMK2D and CACNB2. Interaction with CACNB2 regulates the
trafficking of CACNA1C to the cell membrane (By similarity)
Subcellular location: Cell membrane (By similarity)
5 PDB 3D structures from and Proteopedia for RRAD:
2DPX (3D)        2GJS (3D)        3Q72 (3D)        3Q7P (3D)        3Q7Q (3D)    
Secondary accessions: Q96F39

Explore the universe of human proteins at neXtProt for RRAD: NX_P55042

Explore proteomics data for RRAD at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P55042

  • RRAD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RRAD Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001122322.1  NP_004156.1  

    ENSEMBL proteins: 
     ENSP00000299759   ENSP00000461995   ENSP00000462559   ENSP00000388744  

    Human Recombinant Protein Products for RRAD: 
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    OriGene Protein Over-expression Lysate for RRAD
    OriGene MassSpec for RRAD 
    OriGene Custom Protein Services for RRAD
    GenScript Custom Purified and Recombinant Proteins Services for RRAD
    Novus Biologicals RRAD Protein
    Novus Biologicals RRAD Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RRAD 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----

    RRAD for ontologies           About GeneDecksing



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    LSBio Antibodies in human, mouse, rat for RRAD 

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    Cloud-Clone Corp. ELISAs for RRAD 
    Cloud-Clone Corp. CLIAs for RRAD


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR017358 Small_GTPase_GEM/REM/Rad
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry P55042

    ProtoNet protein and cluster: P55042

    UniProtKB/Swiss-Prot: RAD_HUMAN, P55042
    Similarity: Belongs to the small GTPase superfamily. RGK family


    RRAD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAD_HUMAN, P55042
    Function: May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type
    Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell
    membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII)
    pathway. Inhibits phosphorylation and activation of CAMK2D
    Induction: Down-regulated in failing hearts

         Genatlas biochemistry entry for RRAD:
    Ras-GTPase activating protein family member,with high homology to GEM,overexpressed in non-insulin dependent
    diabetes mellitus (increasing insulin resistant)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding IPI10359610
    GO:0005516calmodulin binding IEA--
    GO:0005525GTP binding IEA--
         
    RRAD for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RRAD:
     Decreased viability with pacli 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rrad):
     cardiovascular system  muscle 

    RRAD for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rradtm1Yec for RRAD

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RRAD 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RRAD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RRAD 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RRAD 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RRAD
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate RRAD (see all 12):
    hsa-miR-30c hsa-miR-520d-5p hsa-miR-7-2* hsa-miR-30d hsa-miR-30a hsa-miR-7-1* hsa-miR-591 hsa-miR-30b
    SwitchGear 3'UTR luciferase reporter plasmidRRAD 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of RRAD 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRAD


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RRAD About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Insulin Signaling
    Insulin Signaling


    1 BioSystems Pathway for RRAD
        Insulin Signaling


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RRAD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/15 Interacting proteins for RRAD (P550421, 3 ENSP000002997594) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    NME1P155313, ENSP000000130344I2D: score=2 STRING: ENSP00000013034
    TPM2P079513, ENSP000003542194I2D: score=2 STRING: ENSP00000354219
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport ----

    RRAD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RRAD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RRAD (RAD)

    6 Novoseek inferred chemical compound relationships for RRAD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 54.4 19 9115241 (4), 9677319 (3), 7876254 (2), 10611312 (1)
    gdp 42.6 2 9115241 (2)
    calcium 33.5 13 16298391 (3), 14623965 (2), 9115241 (2), 17605760 (1) (see all 6)
    serine 30.7 8 9677319 (3), 7876254 (2), 17605760 (1), 9115241 (1)
    threonine 24.3 4 7876254 (2), 9115241 (1)
    glucose 16.6 6 16537411 (3), 8798502 (2), 10611312 (1)

    Search CenterWatch for drugs/clinical trials and news about RRAD / RAD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RRAD gene (2 alternative transcripts): 
    NM_001128850.1  NM_004165.2  

    Unigene Cluster for RRAD:

    Ras-related associated with diabetes
    Hs.1027  [show with all ESTs]
    Unigene Representative Sequence: BC057815
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299759 ENST00000567791 ENST00000568915 ENST00000566577 ENST00000420652(uc002eqn.2 uc002eqo.2)

    miRNA
    Products:
         
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate RRAD (see all 12):
    hsa-miR-30c hsa-miR-520d-5p hsa-miR-7-2* hsa-miR-30d hsa-miR-30a hsa-miR-7-1* hsa-miR-591 hsa-miR-30b
    SwitchGear 3'UTR luciferase reporter plasmidRRAD 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RRAD
    Clone
    Products:
         
    OriGene clones in human, mouse for RRAD (see all 13)
    OriGene ORF clones in mouse, rat for RRAD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RRAD (NM_001128850)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RRAD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRAD
    Sirion Biotech Customized lentivirus for stable overexpression of RRAD 
                         Customized lentivirus expression plasmids for stable overexpression of RRAD 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RRAD
    OriGene qSTAR qPCR primer pairs in human, mouse for RRAD
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RRAD
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RRAD

    Additional mRNA sequence: 

    AK290613.1 BC011645.2 BC057815.1 L24564.1 

    7 DOTS entries:

    DT.315209  DT.101970666  DT.99937691  DT.91820852  DT.92427621  DT.95170096  DT.95170097 

    24/383 AceView cDNA sequences (see all 383):

    BE222628 BU076083 BM424241 AW139693 BC011645 BM710139 AJ346200 BP346765 
    BM010149 AA352310 AI081431 BM091095 CB177402 BX103861 AW629127 BM091401 
    BQ269600 BX384231 AW269858 AU142911 BU190223 AI914622 BG574709 CB529101 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RRAD expression in normal human tissues (normalized intensities)      RRAD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGATTTTTG
    RRAD Expression
    About this image


    RRAD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Heart (Cardiovascular System)
             Primitive Heart Tube Cells Primitive Heart Tube
     
     Ovary (Reproductive System)
             Human Ovarian Fibroblasts (HOF)   
     
     Fibroblast (Uncategorized)
             Human Ovarian Fibroblasts (HOF)   
     
     Skeletal Muscle (Muscoskeletal System)
     
     Larynx (Respiratory System)

    See RRAD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RRAD

    SOURCE GeneReport for Unigene cluster: Hs.1027

    UniProtKB/Swiss-Prot: RAD_HUMAN, P55042
    Tissue specificity: Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser
    amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic
    humans

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRAD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RRAD gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rrad1 , 5 Ras-related associated with diabetes1, 5 85.88(n)1
    92.83(a)1
      8 (53.04 cM)5
    564371  NM_019662.21  NP_062636.21 
     1046280665 
    chicken
    (Gallus gallus)
    Aves RRAD1 Ras-related associated with diabetes 70.37(n)
    75.69(a)
      415790  XM_414151.3  XP_414151.1 
    lizard
    (Anolis carolinensis)
    Reptilia RRAD6
    Ras-related associated with diabetes
    49(a)
    1 ↔ 1
    GL343295.1(271136-279506)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.96332 Transcribed sequence with moderate similarity to protein more 77.13(n)    BX729225.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi06a102 wufi06a10 73.7(n)   327396  BC055120.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rgk11 CG9811-PB 51.34(n)
    42.65(a)
      37219  NM_137567.2  NP_611411.2 


    ENSEMBL Gene Tree for RRAD (if available)
    TreeFam Gene Tree for RRAD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RRAD gene
    REM22  REM12  GEM2  RRAS22  MRAS2  RRAS2  ERAS2  
    15 SIMAP similar genes for RRAD using alignment to 3 protein entries:     RAD_HUMAN (see all proteins):
    GEM    REM1    REM2    RALB    RALA    RIT1
    DIRAS2    RRAS2    NRAS    RAP1A    MRAS    RAP2B
    RERG    RAP1B    RAP2A

    RRAD for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RRAD
    PGOHUM00000262936


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/100 SNPs in RRAD are shown (see all 100)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1869303941,2
    --66955344(+) GCAACG/TCCAGG 2 -- ds50010--------
    rs1912065131,2
    --66955361(+) TGCAGA/CAAGAG 2 -- ds50010--------
    rs37437251,2
    C,F,H--66955434(+) GACCCG/AATGCC 2 -- ds500119Minor allele frequency- A:0.07EA NS NA WA 3616
    rs1393020211,2
    C--66955516(+) CCCCAC/TCCCTC 2 -- ds50010--------
    rs1832095581,2
    --66955523(+) CCTCAA/CCTTCA 2 -- ds50010--------
    rs1137160311,2
    --66955735(+) CGCTGA/CGGCTG 2 -- ut310--------
    rs1428020191,2
    C--66955762(+) GCCTGC/TGCATG 2 -- ut310--------
    rs10657631,2
    F--66955910(-) TGCCCC/TGGGTG 2 -- ut31 ese32Minor allele frequency- T:0.01MN 246
    rs2012455511,2
    --66955951(+) TTCGTC/TTCCCA 2 -- ut310--------
    rs2002550531,2
    --66955961(+) ACCATA/CGTGGG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for RRAD (66955582 - 66959547 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RRAD:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv906791CNV Loss21882294
    nsv906792CNV Loss21882294
    dgv2885n71CNV Loss21882294
    nsv827706CNV Loss20364138

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 179503    OMIM disorders: --

    12 diseases for RRAD:    About MalaCards
    hepatic angiomyolipoma    skeletal muscle regeneration    angiomyolipoma    glucose intolerance
    insulin resistance    lateral sclerosis    amyotrophic lateral sclerosis    diabetes mellitus
    nasopharyngitis    hepatitis    breast cancer    leukemia


    RRAD for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for RRAD gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin sensitivity 27.4 2 8603763 (1), 16537411 (1)
    niddm 20.3 6 8603763 (4), 16537411 (1)
    insulin resistance 14.4 3 16537411 (2), 8603763 (1)
    metastasis 0 3 10611312 (2), 9677319 (1)

    Genetic Association Database (GAD): RRAD

    Export disorders for RRAD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RRAD gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with RRAD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rad and Rad-related GTPases interact with calmodulin and calmodulin- dependent protein kinase II. (PubMed id 9115241)1, 2, 9 Moyers J.S.... Kahn C.R. (1997)
    2. Rad GTPase deficiency leads to cardiac hypertrophy. (PubMed id 18056528)1, 2, 9 Chang L....Chen Y.E. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Trinucleotide repeats at the rad locus. Allele distributions in NIDDM and mapping to a 3-cM region on chromosome 16q. (PubMed id 7859947)1, 3 Doria A....Krolewski A.S. (1995)
    5. Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans. (PubMed id 8248782)1, 2 Reynet C. and Kahn C.R. (1993)
    6. Rad, a novel Ras-related GTPase, interacts with skeletal muscle beta-tropomyosin. (PubMed id 8557685)1, 9 Zhu J....Kahn C.R. (1996)
    7. Effects of phosphorylation on function of the Rad GTPase. (PubMed id 9677319)1, 9 Moyers J.S....Kahn C.R. (1998)
    8. Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity. (PubMed id 7876254)1, 9 Zhu J....Kahn C.R. (1995)
    9. Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation. (PubMed id 10611312)1, 9 Zhu J....Kahn C.R. (1999)
    10. Overexpression of Rad inhibits glucose uptake in cultured muscle and fat cells. (PubMed id 8798502)1, 9 Moyers J.S....Kahn C.R. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6236 HGNC: 10446 AceView: RRADandCGI-128 Ensembl:ENSG00000166592 euGenes: HUgn6236
    ECgene: RRAD H-InvDB: RRAD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RRAD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RRAD Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RRAD gene:
    Search GeneIP for patents involving RRAD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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