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Aliases for RRAD Gene

Aliases for RRAD Gene

  • Ras-Related Associated With Diabetes 2 3
  • Ras Associated With Diabetes 3 4
  • RAD1 3 4
  • RAD 3 4
  • RAS (RAD And GEM) Like GTP Binding 3 3
  • GTP-Binding Protein RAD 3
  • REM3 3

External Ids for RRAD Gene

Summaries for RRAD Gene

GeneCards Summary for RRAD Gene

RRAD (Ras-Related Associated With Diabetes) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Insulin Signaling. GO annotations related to this gene include GTP binding and calmodulin binding. An important paralog of this gene is HRAS.

UniProtKB/Swiss-Prot for RRAD Gene

  • May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.

Gene Wiki entry for RRAD Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRAD Gene

Genomics for RRAD Gene

Genomic Location for RRAD Gene

Start:
66,921,679 bp from pter
End:
66,925,644 bp from pter
Size:
3,966 bases
Orientation:
Minus strand

Genomic View for RRAD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RRAD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRAD Gene

Regulatory Elements for RRAD Gene

Transcription factor binding sites by QIAGEN in the RRAD gene promoter:

Proteins for RRAD Gene

  • Protein details for RRAD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55042-RAD_HUMAN
    Recommended name:
    GTP-binding protein RAD
    Protein Accession:
    P55042
    Secondary Accessions:
    • Q96F39

    Protein attributes for RRAD Gene

    Size:
    308 amino acids
    Molecular mass:
    33245 Da
    Quaternary structure:
    • Interacts with calmodulin preferentially in the inactive, GDP-bound form. Binds CAMKII which is capable of phosphorylating RAD in vitro. Interacts with CAMK2D and CACNB2. Interaction with CACNB2 regulates the trafficking of CACNA1C to the cell membrane (By similarity).

    Three dimensional structures from OCA and Proteopedia for RRAD Gene

neXtProt entry for RRAD Gene

Proteomics data for RRAD Gene at MOPED

Post-translational modifications for RRAD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RRAD Gene

No data available for DME Specific Peptides for RRAD Gene

Domains for RRAD Gene

Suggested Antigen Peptide Sequences for RRAD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55042

UniProtKB/Swiss-Prot:

RAD_HUMAN
Family:
  • Belongs to the small GTPase superfamily. RGK family.:
    • P55042
genes like me logo Genes that share domains with RRAD: view

No data available for Gene Families for RRAD Gene

Function for RRAD Gene

Molecular function for RRAD Gene

GENATLAS Biochemistry: Ras-GTPase activating protein family member,with high homology to GEM,overexpressed in non-insulin dependent diabetes mellitus (increasing insulin resistant)
UniProtKB/Swiss-Prot Function: May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.
UniProtKB/Swiss-Prot Induction: Down-regulated in failing hearts.

Gene Ontology (GO) - Molecular Function for RRAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 8248782
GO:0005515 protein binding IPI 10359610
GO:0005516 calmodulin binding IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RRAD: view

Phenotypes for RRAD Gene

MGI mutant phenotypes for RRAD:
inferred from 1 alleles
GenomeRNAi human phenotypes for RRAD:
genes like me logo Genes that share phenotypes with RRAD: view

Animal Models for RRAD Gene

MGI Knock Outs for RRAD:

miRNA for RRAD Gene

miRTarBase miRNAs that target RRAD

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RRAD Gene

Localization for RRAD Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRAD Gene

Cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RRAD Gene COMPARTMENTS Subcellular localization image for RRAD gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for RRAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RRAD: view

Pathways for RRAD Gene

genes like me logo Genes that share pathways with RRAD: view

Gene Ontology (GO) - Biological Process for RRAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0008152 metabolic process TAS 8248782
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with RRAD: view

Compounds for RRAD Gene

(6) Novoseek inferred chemical compound relationships for RRAD Gene

Compound -log(P) Hits PubMed IDs
gtp 54.4 10
gdp 42.6 2
calcium 33.5 10
serine 30.7 7
threonine 24.3 3
genes like me logo Genes that share compounds with RRAD: view

Transcripts for RRAD Gene

Unigene Clusters for RRAD Gene

Ras-related associated with diabetes:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RRAD Gene

No ASD Table

Relevant External Links for RRAD Gene

GeneLoc Exon Structure for
RRAD
ECgene alternative splicing isoforms for
RRAD

Expression for RRAD Gene

mRNA expression in normal human tissues for RRAD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RRAD Gene

This gene is overexpressed in Muscle - Skeletal (16.2), Heart - Left Ventricle (6.8), and Heart - Atrial Appendage (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RRAD Gene

SOURCE GeneReport for Unigene cluster for RRAD Gene Hs.1027

mRNA Expression by UniProt/SwissProt for RRAD Gene

P55042-RAD_HUMAN
Tissue specificity: Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.
genes like me logo Genes that share expressions with RRAD: view

Orthologs for RRAD Gene

This gene was present in the common ancestor of animals.

Orthologs for RRAD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RRAD 35
  • 99.24 (n)
  • 99.03 (a)
RRAD 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RRAD 35
  • 89.28 (n)
  • 96.11 (a)
RRAD 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RRAD 35
  • 86.64 (n)
  • 93.97 (a)
RRAD 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rrad 35
  • 85.8 (n)
  • 93.13 (a)
Rrad 16
Rrad 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RRAD 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RRAD 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rrad 35
  • 85.68 (n)
  • 93.13 (a)
chicken
(Gallus gallus)
Aves RRAD 35
  • 70.02 (n)
  • 75.35 (a)
RRAD 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RRAD 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rrad 35
  • 64 (n)
  • 70.83 (a)
Str.9633 35
zebrafish
(Danio rerio)
Actinopterygii rrad 35
  • 68.18 (n)
  • 67.94 (a)
rrad 36
  • 67 (a)
OneToOne
wufi06a10 35
fruit fly
(Drosophila melanogaster)
Insecta CG42541 36
  • 7 (a)
ManyToMany
Rgk1 36
  • 18 (a)
ManyToMany
Rgk2 36
  • 12 (a)
ManyToMany
Rgk3 36
  • 19 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y52B11A.4 36
  • 16 (a)
OneToMany
Species with no ortholog for RRAD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRAD Gene

ENSEMBL:
Gene Tree for RRAD (if available)
TreeFam:
Gene Tree for RRAD (if available)

Paralogs for RRAD Gene

Paralogs for RRAD Gene

Selected SIMAP similar genes for RRAD Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for RRAD Gene

genes like me logo Genes that share paralogs with RRAD: view

Variants for RRAD Gene

Sequence variations from dbSNP and Humsavar for RRAD Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1062537 -- 66,921,728(-) AGCTA(C/T)TTGTT utr-variant-3-prime
rs1065763 -- 66,922,007(-) TGCCC(C/T)GGGTG utr-variant-3-prime
rs3743725 -- 66,921,531(+) GACCC(A/G)ATGCC downstream-variant-500B
rs4783744 -- 66,922,544(+) CCTGC(A/G)TTTAA intron-variant
rs7198458 - 66,924,983(+) GACCC(G/T)GGGTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RRAD Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
nsv827706 CNV Loss 20364138
nsv906791 CNV Loss 21882294
nsv906792 CNV Loss 21882294

Relevant External Links for RRAD Gene

HapMap Linkage Disequilibrium report
RRAD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRAD Gene

Disorders for RRAD Gene

(4) Novoseek inferred disease relationships for RRAD Gene

Disease -log(P) Hits PubMed IDs
insulin sensitivity 27.4 2
niddm 20.3 5
insulin resistance 14.4 3
metastasis 0 3

Relevant External Links for RRAD

Genetic Association Database (GAD)
RRAD
genes like me logo Genes that share disorders with RRAD: view

No data available for UniProtKB/Swiss-Prot for RRAD Gene

Publications for RRAD Gene

  1. Rad and Rad-related GTPases interact with calmodulin and calmodulin- dependent protein kinase II. (PMID: 9115241) Moyers J.S. … Kahn C.R. (J. Biol. Chem. 1997) 3 4 23
  2. Rad GTPase deficiency leads to cardiac hypertrophy. (PMID: 18056528) Chang L. … Chen Y.E. (Circulation 2007) 3 4 23
  3. Trinucleotide repeats at the rad locus. Allele distributions in NIDDM and mapping to a 3-cM region on chromosome 16q. (PMID: 7859947) Doria A. … Krolewski A.S. (Diabetes 1995) 2 3
  4. Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans. (PMID: 8248782) Reynet C. … Kahn C.R. (Science 1993) 3 4
  5. Effects of phosphorylation on function of the Rad GTPase. (PMID: 9677319) Moyers J.S. … Kahn C.R. (Biochem. J. 1998) 3 23

Products for RRAD Gene

Sources for RRAD Gene

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