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Aliases for RRAD Gene

Aliases for RRAD Gene

  • Ras-Related Associated With Diabetes 2 3 5
  • Ras Associated With Diabetes 3 4
  • RAD1 3 4
  • RAD 3 4
  • RAS (RAD And GEM) Like GTP Binding 3 3
  • REM3 3

External Ids for RRAD Gene

Previous GeneCards Identifiers for RRAD Gene

  • GC16M057650
  • GC16M067333
  • GC16M066691
  • GC16M066731
  • GC16M065513
  • GC16M066955
  • GC16M052829

Summaries for RRAD Gene

GeneCards Summary for RRAD Gene

RRAD (Ras-Related Associated With Diabetes) is a Protein Coding gene. Diseases associated with RRAD include diabetes mellitus, noninsulin-dependent. Among its related pathways are Gene Expression and Cell Cycle, Mitotic. GO annotations related to this gene include GTP binding and calmodulin binding. An important paralog of this gene is HRAS.

UniProtKB/Swiss-Prot for RRAD Gene

  • May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.

Gene Wiki entry for RRAD Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRAD Gene

Genomics for RRAD Gene

Regulatory Elements for RRAD Gene

Transcription factor binding sites by QIAGEN in the RRAD gene promoter:

Genomic Location for RRAD Gene

Chromosome:
16
Start:
66,921,679 bp from pter
End:
66,925,644 bp from pter
Size:
3,966 bases
Orientation:
Minus strand

Genomic View for RRAD Gene

Genes around RRAD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRAD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRAD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRAD Gene

Proteins for RRAD Gene

  • Protein details for RRAD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55042-RAD_HUMAN
    Recommended name:
    GTP-binding protein RAD
    Protein Accession:
    P55042
    Secondary Accessions:
    • Q96F39

    Protein attributes for RRAD Gene

    Size:
    308 amino acids
    Molecular mass:
    33245 Da
    Quaternary structure:
    • Interacts with calmodulin preferentially in the inactive, GDP-bound form. Binds CAMKII which is capable of phosphorylating RAD in vitro. Interacts with CAMK2D and CACNB2. Interaction with CACNB2 regulates the trafficking of CACNA1C to the cell membrane (By similarity).

    Three dimensional structures from OCA and Proteopedia for RRAD Gene

neXtProt entry for RRAD Gene

Proteomics data for RRAD Gene at MOPED

Post-translational modifications for RRAD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RRAD Gene

Antibody Products

No data available for DME Specific Peptides for RRAD Gene

Domains & Families for RRAD Gene

Gene Families for RRAD Gene

Suggested Antigen Peptide Sequences for RRAD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55042

UniProtKB/Swiss-Prot:

RAD_HUMAN :
  • Belongs to the small GTPase superfamily. RGK family.
Family:
  • Belongs to the small GTPase superfamily. RGK family.
genes like me logo Genes that share domains with RRAD: view

Function for RRAD Gene

Molecular function for RRAD Gene

GENATLAS Biochemistry:
Ras-GTPase activating protein family member,with high homology to GEM,overexpressed in non-insulin dependent diabetes mellitus (increasing insulin resistant)
UniProtKB/Swiss-Prot Function:
May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.
UniProtKB/Swiss-Prot Induction:
Down-regulated in failing hearts.

Gene Ontology (GO) - Molecular Function for RRAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10359610
genes like me logo Genes that share ontologies with RRAD: view
genes like me logo Genes that share phenotypes with RRAD: view

Animal Models for RRAD Gene

MGI Knock Outs for RRAD:

Animal Model Products

  • Taconic Biosciences Mouse Models for RRAD

miRNA for RRAD Gene

miRTarBase miRNAs that target RRAD

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RRAD Gene

Localization for RRAD Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRAD Gene

Cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RRAD Gene COMPARTMENTS Subcellular localization image for RRAD gene
Compartment Confidence
plasma membrane 4
nucleus 3
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RRAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with RRAD: view

Pathways & Interactions for RRAD Gene

genes like me logo Genes that share pathways with RRAD: view

Gene Ontology (GO) - Biological Process for RRAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with RRAD: view

No data available for SIGNOR curated interactions for RRAD Gene

Drugs & Compounds for RRAD Gene

(3) Drugs for RRAD Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for RRAD Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RRAD: view

Transcripts for RRAD Gene

Unigene Clusters for RRAD Gene

Ras-related associated with diabetes:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RRAD Gene

No ASD Table

Relevant External Links for RRAD Gene

GeneLoc Exon Structure for
RRAD
ECgene alternative splicing isoforms for
RRAD

Expression for RRAD Gene

mRNA expression in normal human tissues for RRAD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RRAD Gene

This gene is overexpressed in Muscle - Skeletal (x16.2), Heart - Left Ventricle (x6.8), and Heart - Atrial Appendage (x6.8).

Protein differential expression in normal tissues from HIPED for RRAD Gene

This gene is overexpressed in Gallbladder (23.7) and Fetal heart (18.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RRAD Gene



SOURCE GeneReport for Unigene cluster for RRAD Gene Hs.1027

mRNA Expression by UniProt/SwissProt for RRAD Gene

P55042-RAD_HUMAN
Tissue specificity: Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.
genes like me logo Genes that share expression patterns with RRAD: view

Protein tissue co-expression partners for RRAD Gene

Primer Products

In Situ Assay Products

Orthologs for RRAD Gene

This gene was present in the common ancestor of animals.

Orthologs for RRAD Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RRAD 35
  • 89.28 (n)
  • 96.11 (a)
RRAD 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RRAD 35
  • 86.64 (n)
  • 93.97 (a)
RRAD 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rrad 35
  • 85.8 (n)
  • 93.13 (a)
Rrad 16
Rrad 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RRAD 35
  • 99.24 (n)
  • 99.03 (a)
RRAD 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rrad 35
  • 85.68 (n)
  • 93.13 (a)
oppossum
(Monodelphis domestica)
Mammalia RRAD 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RRAD 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves RRAD 35
  • 70.02 (n)
  • 75.35 (a)
RRAD 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RRAD 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rrad 35
  • 64 (n)
  • 70.83 (a)
Str.9633 35
zebrafish
(Danio rerio)
Actinopterygii rrad 35
  • 68.18 (n)
  • 67.94 (a)
wufi06a10 35
rrad 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42541 36
  • 7 (a)
ManyToMany
Rgk1 36
  • 18 (a)
ManyToMany
Rgk2 36
  • 12 (a)
ManyToMany
Rgk3 36
  • 19 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y52B11A.4 36
  • 16 (a)
OneToMany
Species with no ortholog for RRAD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRAD Gene

ENSEMBL:
Gene Tree for RRAD (if available)
TreeFam:
Gene Tree for RRAD (if available)

Paralogs for RRAD Gene

Paralogs for RRAD Gene

(15) SIMAP similar genes for RRAD Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for RRAD Gene

genes like me logo Genes that share paralogs with RRAD: view

Variants for RRAD Gene

Sequence variations from dbSNP and Humsavar for RRAD Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs7198458 - 66,924,983(+) GACCC(G/T)GGGTC reference, missense
rs1062537 -- 66,921,728(-) AGCTA(C/T)TTGTT utr-variant-3-prime
rs1065763 -- 66,922,007(-) TGCCC(C/T)GGGTG utr-variant-3-prime
rs3743725 -- 66,921,531(+) GACCC(A/G/T)ATGCC downstream-variant-500B
rs4783744 -- 66,922,544(+) CCTGC(A/G)TTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RRAD Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
nsv827706 CNV Loss 20364138
nsv906791 CNV Loss 21882294
nsv906792 CNV Loss 21882294

Variation tolerance for RRAD Gene

Residual Variation Intolerance Score: 33.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RRAD Gene

HapMap Linkage Disequilibrium report
RRAD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRAD Gene

Disorders for RRAD Gene

MalaCards: The human disease database

(1) MalaCards diseases for RRAD Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
diabetes mellitus, noninsulin-dependent
  • diabetes mellitus, noninsulin-dependent, 2
- elite association - COSMIC cancer census association via MalaCards
Search RRAD in MalaCards View complete list of genes associated with diseases

Relevant External Links for RRAD

Genetic Association Database (GAD)
RRAD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RRAD
genes like me logo Genes that share disorders with RRAD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RRAD Gene

Publications for RRAD Gene

  1. Rad and Rad-related GTPases interact with calmodulin and calmodulin- dependent protein kinase II. (PMID: 9115241) Moyers J.S. … Kahn C.R. (J. Biol. Chem. 1997) 3 4 23 67
  2. Rad GTPase deficiency leads to cardiac hypertrophy. (PMID: 18056528) Chang L. … Chen Y.E. (Circulation 2007) 3 23
  3. Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation. (PMID: 10611312) Zhu J. … Kahn C.R. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 23
  4. Effects of phosphorylation on function of the Rad GTPase. (PMID: 9677319) Moyers J.S. … Kahn C.R. (Biochem. J. 1998) 3 23
  5. Rad, a novel Ras-related GTPase, interacts with skeletal muscle beta-tropomyosin. (PMID: 8557685) Zhu J. … Kahn C.R. (J. Biol. Chem. 1996) 3 23

Products for RRAD Gene

Sources for RRAD Gene

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