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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RRAD Gene

protein-coding   GIFtS: 53
GCID: GC16M066955

Ras-related associated with diabetes

 Explore 11 diseases affiliated with
RRAD via our new
 Human Malady Compendium 
Biological research products
for RRAD
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ras-Related Associated With Diabetes1 2     RAD12 3
RAD1 2 3     GTP-Binding Protein RAD2
REM31 2     RAS (RAD And GEM) Like GTP Binding 32
Ras Associated With Diabetes2 3     

External Ids:    HGNC: 104461   Entrez Gene: 62362   Ensembl: ENSG000001665927   OMIM: 1795035   UniProtKB: P550423   

Export aliases for RRAD gene to outside databases

Previous GC identifers: GC16M057650 GC16M067333 GC16M066691 GC16M066731 GC16M065513 GC16M052829


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RAD_HUMAN, P55042
Function: May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type
Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane
(By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits
phosphorylation and activation of CAMK2D

Gene Wiki entry for RRAD


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RRAD gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRRAD promoter sequence
   Search SABiosciences Chromatin IP Primers for RRAD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RRAD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22

RRAD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RRAD gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M066955:  view genomic region     (about GC identifiers)

Start:
66,955,582 bp from pter      End:
66,959,547 bp from pter
Size:
3,966 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RAD_HUMAN, P55042 (See protein sequence)
Recommended Name: GTP-binding protein RAD  
Size: 308 amino acids; 33245 Da
Subunit: Interacts with calmodulin preferentially in the inactive, GDP-bound form. Binds CAMKII which is capable of
phosphorylating RAD in vitro. Interacts with CAMK2D and CACNB2. Interaction with CACNB2 regulates the trafficking of
CACNA1C to the cell membrane (By similarity)
Subcellular location: Cell membrane (By similarity)
5 PDB 3D structures from and Proteopedia for RRAD:
2DPX (3D)        2GJS (3D)        3Q72 (3D)        3Q7P (3D)        3Q7Q (3D)    
Secondary accessions: Q96F39

Explore the universe of human proteins at neXtProt for RRAD: NX_P55042

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P55042

  • RRAD Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001122322.1  NP_004156.1  

    ENSEMBL proteins: 
     ENSP00000299759   ENSP00000461995   ENSP00000462559   ENSP00000388744  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 2): RRAD
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    Novus Biologicals RRAD Protein
    Novus Biologicals RRAD Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RRAD

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--


    RRAD for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RRAD


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RRAD for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017358 Small_GTPase_GEM/REM/Rad
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry P55042

    ProtoNet protein and cluster: P55042

    UniProtKB/Swiss-Prot: RAD_HUMAN, P55042
    Similarity: Belongs to the small GTPase superfamily. RGK family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: RAD_HUMAN, P55042
    Function: May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type
    Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane
    (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits
    phosphorylation and activation of CAMK2D
    Induction: Down-regulated in failing hearts

         Genatlas biochemistry entry for RRAD:
    Ras-GTPase activating protein family member,with high homology to GEM,overexpressed in non-insulin dependent diabetes
    mellitus (increasing insulin resistant)

    miRNA
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    OriGene 3'-UTR Clone (see all 2): RRAD
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RRAD
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate RRAD (see all 12):
    hsa-miR-30c hsa-miR-520d-5p hsa-miR-7-2* hsa-miR-30d hsa-miR-30a hsa-miR-7-1* hsa-miR-591 hsa-miR-30b
    SwitchGear 3'UTR luciferase reporter plasmidRRAD 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RRAD (see all 7)
    OriGene shRNA RFP: RRAD
    OriGene siRNA: RRAD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RRAD

    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRAD

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005516calmodulin binding IEA--
    GO:0005525GTP binding IEA--


    RRAD for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for RRAD:
     Decreased viability with pacli 

    Animal Models:
         Mouse knock-out Rradtm1Yec for RRAD
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rrad):
     cardiovascular system  muscle 

    RRAD for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Insulin Signaling
    Insulin Signaling1.00


    1 BioSystems Pathway for RRAD 
        Insulin Signaling


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RRAD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/15 Interacting proteins for RRAD (P550421, 3 ENSP000002997594) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    NME1P155313, ENSP000000130344I2D: score=2 STRING: ENSP00000013034
    TPM2P079513, ENSP000003542194I2D: score=2 STRING: ENSP00000354219
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0030308negative regulation of cell growth ----


    RRAD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RRAD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RRAD
    6 Novoseek chemical compound relationships for RRAD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 54.4 19 9115241 (4), 9677319 (3), 7876254 (2), 10611312 (1)
    gdp 42.6 2 9115241 (2)
    calcium 33.5 13 16298391 (3), 14623965 (2), 9115241 (2), 17605760 (1) (see all 6)
    serine 30.7 8 9677319 (3), 7876254 (2), 17605760 (1), 9115241 (1)
    threonine 24.3 4 7876254 (2), 9115241 (1)
    glucose 16.6 6 16537411 (3), 8798502 (2), 10611312 (1)

    Search CenterWatch for drugs/clinical trials and news about RRAD / RAD 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RRAD gene (2 alternative transcripts): 
    NM_001128850.1  NM_004165.2  

    Unigene Cluster for RRAD:

    Ras-related associated with diabetes
    Hs.1027  [show with all ESTs]
    Unigene Representative Sequence: BC057815
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299759 ENST00000567791 ENST00000568915 ENST00000566577 ENST00000420652(uc002eqn.2 uc002eqo.2)


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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate RRAD (see all 12):
    hsa-miR-30c hsa-miR-520d-5p hsa-miR-7-2* hsa-miR-30d hsa-miR-30a hsa-miR-7-1* hsa-miR-591 hsa-miR-30b
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    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RRAD
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): RRAD (NM_001128850)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RRAD 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RRAD
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RRAD

    Additional cDNA sequence: 

    AK290613.1 BC011645.2 BC057815.1 L24564.1 

    7 DOTS entries:

    DT.315209  DT.101970666  DT.99937691  DT.91820852  DT.92427621  DT.95170096  DT.95170097 

    24/383 AceView cDNA sequences (see all 383):

    BM698540 BG328694 BM673269 BG574709 CB177402 F31069 AI424543 BQ018199 
    BC001733 BE253892 AW134592 BU190223 AJ346200 BM091401 AA352310 BM424241 
    BQ269600 BE222628 AW139693 BX384231 AU142911 AW269858 BU076083 CA952743 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RRAD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGATTTTTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See RRAD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RRAD

    SOURCE GeneReport for Unigene cluster: Hs.1027

    UniProtKB/Swiss-Prot: RAD_HUMAN, P55042
    Tissue specificity: Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts
    in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RRAD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RRAD gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RRAD1 Ras-related associated with diabetes 70.37(n)
    75.69(a)
      415790  XM_414151.3  XP_414151.1 
    lizard
    (Anolis carolinensis)
    Reptilia RRAD6
    --
    68(a)
    1 ↔ 1
    GL343295.1(273020-279488)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.96332 Transcribed sequence with moderate similarity to protein more 77.13(n)    BX729225.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi06a102 wufi06a10 73.7(n)   327396  BC055120.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rgk11 CG9811-PB 51.34(n)
    42.65(a)
      37219  NM_137567.2  NP_611411.2 
    worm
    (Caenorhabditis elegans)
    Secernentea Y52B11A.46
    --
    10(a)
    1 → many
    I(10979600-11004276)


    ENSEMBL Gene Tree for RRAD (if available)
    TreeFam Gene Tree for RRAD (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RRAD gene
    REM12  RALA2  RIT22  RIT12  RRAS2  ERAS2  RALB2  NRAS2  
    REM22  KRAS2  GEM2  RRAS22  HRAS2  MRAS2  
    15 SIMAP similar genes for RRAD using alignment to 3 protein entries:     RAD_HUMAN (see all proteins):
    GEM    REM1    REM2    RALB    RALA    RIT1
    DIRAS2    RRAS2    NRAS    RAP1A    MRAS    RAP2B
    RERG    RAP1B    RAP2A

    RRAD for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RRAD
    PGOHUM00000262936


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/66 NCBI SNPs in RRAD are shown (see all 66    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1869303941,2
    --66955344(+) GCAACG/TCCAGG 2 -- ds50010--------
    rs1912065131,2
    --66955361(+) TGCAGA/CAAGAG 2 -- ds50010--------
    rs37437251,2
    C,F,H,--66955434(+) GACCCG/AATGCC 2 -- ds500119Minor allele frequency- A:0.07EA NS NA WA 3616
    rs1393020211,2
    --66955516(+) CCCCAC/TCCCTC 2 -- ds50010--------
    rs1832095581,2
    --66955523(+) CCTCAA/CCTTCA 2 -- ds50010--------
    rs1137160311,2
    --66955735(+) CGCTGA/CGGCTG 2 -- ut310--------
    rs1428020191,2
    --66955762(+) GCCTGC/TGCATG 2 -- ut310--------
    rs10657631,2
    --66955910(-) TGCCCC/TGGGTG 2 -- ut31 ese32Minor allele frequency- T:0.01MN 246
    rs2012455511,2
    --66955951(+) TTCGTC/TTCCCA 2 -- ut310--------
    rs2002550531,2
    --66955961(+) ACCATA/CGTGGG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for RRAD (66955582 - 66959547 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RRAD: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RRAD
    DNA2.0 Custom Variant and Variant Library Synthesis for RRAD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RRAD for disorders           About GeneDecksing

    OMIM gene information: 179503    OMIM disorders: --

    11 diseases for RRAD:    About MalaCards
    skeletal muscle regeneration    type 2 diabetes mellitus    glucose intolerance    amyotrophic lateral sclerosis
    insulin resistance    lateral sclerosis    diabetes mellitus    hepatic angiomyolipoma
    angiomyolipoma    breast cancer    hepatitis

    4 Novoseek disease relationships for RRAD gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin sensitivity 27.4 2 8603763 (1), 16537411 (1)
    niddm 20.3 6 8603763 (4), 16537411 (1)
    insulin resistance 14.4 3 16537411 (2), 8603763 (1)
    metastasis 0 3 10611312 (2), 9677319 (1)

    Genetic Association Database (GAD): RRAD

    Export disorders for RRAD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RRAD gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with RRAD)
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    1. Rad and Rad-related GTPases interact with calmodulin and calmodulin- dependent protein kinase II. (PubMed id 9115241)1, 2, 9 Moyers J.S.... Kahn C.R. (1997)
    2. Rad GTPase deficiency leads to cardiac hypertrophy. (PubMed id 18056528)1, 2, 9 Chang L....Chen Y.E. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Trinucleotide repeats at the rad locus. Allele distributions in NIDDM and mapping to a 3-cM region on chromosome 16q. (PubMed id 7859947)1, 3 Doria A....Krolewski A.S. (1995)
    5. Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans. (PubMed id 8248782)1, 2 Reynet C. and Kahn C.R. (1993)
    6. Rad, a novel Ras-related GTPase, interacts with skeletal muscle beta-tropomyosin. (PubMed id 8557685)1, 9 Zhu J....Kahn C.R. (1996)
    7. Effects of phosphorylation on function of the Rad GTPase. (PubMed id 9677319)1, 9 Moyers J.S....Kahn C.R. (1998)
    8. Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity. (PubMed id 7876254)1, 9 Zhu J....Kahn C.R. (1995)
    9. Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation. (PubMed id 10611312)1, 9 Zhu J....Kahn C.R. (1999)
    10. Overexpression of Rad inhibits glucose uptake in cultured muscle and fat cells. (PubMed id 8798502)1, 9 Moyers J.S....Kahn C.R. (1996)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6236 HGNC: 10446 AceView: RRADandCGI-128 Ensembl:ENSG00000166592 euGenes: HUgn6236
    ECgene: RRAD H-InvDB: RRAD

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for RRAD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RRAD Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
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