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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RQCD1 Gene

protein-coding   GIFtS: 58
GCID: GC02P219433

RCD1 Required For Cell Differentiation1 Homolog (S. Pombe)

(Previous names: rcd1 (required for cell differentiation, S.pombe) homolog...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RCD1 Required For Cell Differentiation1 Homolog (S. Pombe)1 2     CT1292
CNOT92 3 5     RCD-12
RCD12 3 5     Cell Differentiation Protein RCD1 Homolog2
Cancer/Testis Antigen 1291 2     Protein Involved In Sexual Development2
CCR4-NOT Transcription Complex Subunit 92 3     Rcd-13
Rcd1 (Required For Cell Differentiation, S.Pombe) Homolog 11     

External Ids:    HGNC: 104451   Entrez Gene: 91252   Ensembl: ENSG000001445807   OMIM: 6120545   UniProtKB: Q926003   

Export aliases for RQCD1 gene to outside databases

Previous GC identifers: GC02P217449 GC02P218154 GC02P219397 GC02P219636 GC02P219259 GC02P219141 GC02P211286


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RQCD1 Gene:
This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional
cofactor and a core protein of the CCR4-NOT complex. It may be involved in signal transduction as well as
retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been
described for this gene. (provided by RefSeq, Oct 2012)

GeneCards Summary for RQCD1 Gene: 
RQCD1 (RCD1 required for cell differentiation1 homolog (S. pombe)) is a protein-coding gene. Diseases associated with RQCD1 include breast cancer, and prostatitis, and among its related super-pathways are Deadenylation-dependent mRNA decay and Metabolism of RNA. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: RCD1_HUMAN, Q92600
Function: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to
various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression
during translational initiation and general transcription regulation. Additional complex functions may be a
consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent
transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as
poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind
poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect
ESR1-mediated transcription that is not only slightly increased, if at all




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RQCD1 gene promoter:
         SRF   AML1a   SRF (504 AA)   HNF-3beta   Nkx6-1   E2F-1   E2F   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRQCD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RQCD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RQCD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

RQCD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RQCD1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P219433:  view genomic region     (about GC identifiers)

Start:
219,433,303 bp from pter      End:
219,461,803 bp from pter
Size:
28,501 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RCD1_HUMAN, Q92600 (See protein sequence)
Recommended Name: Cell differentiation protein RCD1 homolog  
Size: 299 amino acids; 33631 Da
Subunit: Homodimer. Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the
participation of probably mutually exclusive catalytic subunits. Interacts with MYB, ATF2, RARA, RARB, RARG,
RXRA, RXRB and RXRG. Identified in a complex with ATF2 bound to target DNA (By similarity). Interacts with NANOS2
(By similarity). Directly interacts with ZNF335
Subcellular location: Nucleus (By similarity). Cytoplasm, P-body (By similarity). Note=NANOS2 promotes its
localization to P-body (By similarity)
Sequence caution: Sequence=AAH07102.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for RQCD1:
2FV2 (3D)    
Secondary accessions: B2RPI0 Q96IX4

Explore the universe of human proteins at neXtProt for RQCD1: NX_Q92600

Explore proteomics data for RQCD1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92600

  • RQCD1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RQCD1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001258563.1  NP_001258564.1  NP_005435.1  

    ENSEMBL proteins: 
     ENSP00000273064   ENSP00000415607   ENSP00000392394   ENSP00000295701   ENSP00000396938  
     ENSP00000441357   ENSP00000443687  
    Reactome Protein details: Q92600
    Human Recombinant Protein Products for RQCD1: 
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    Cloud-Clone Corp. Proteins for RQCD1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body ISS--
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0030014CCR4-NOT complex IDA19558367

    RQCD1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011989 ARM-like
     IPR007216 Rcd1
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q92600

    ProtoNet protein and cluster: Q92600

    UniProtKB/Swiss-Prot: RCD1_HUMAN, Q92600
    Similarity: Belongs to the RCD1 family


    RQCD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RCD1_HUMAN, Q92600
    Function: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to
    various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression
    during translational initiation and general transcription regulation. Additional complex functions may be a
    consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent
    transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as
    poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind
    poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect
    ESR1-mediated transcription that is not only slightly increased, if at all

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI18180299
         
    RQCD1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RQCD1:
     Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rqcd1):
     embryogenesis  homeostasis/metabolism  mortality/aging  nervous system  no phenotypic analysis 

    RQCD1 for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RQCD1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.49
    Deadenylation of mRNA0.47
    RNA degradation0.49
    2Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    3Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5        Reactome Pathways for RQCD1
        Deadenylation of mRNA
    Deadenylation-dependent mRNA decay
    Metabolism of RNA
    Metabolism of mRNA
    Gene Expression


    1         Kegg Pathway  (Kegg details for RQCD1):
        RNA degradation


    RQCD1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RQCD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/108 Interacting proteins for RQCD1 (Q926002, 3 ENSP000002730644) via UniProtKB, MINT, STRING, and/or I2D (see all 108)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3MINT-48431 I2D: score=2 
    CNOT6Q9ULM63, ENSP000002619514I2D: score=7 STRING: ENSP00000261951
    CNOT1A5YKK63, ENSP000003209494STRING: ENSP00000320949 I2D: score=6 
    CNOT8Q9UFF93, ENSP000002858964I2D: score=5 STRING: ENSP00000285896
    CNOT3O751753, ENSP000002212324I2D: score=4 STRING: ENSP00000221232
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006417regulation of translation IEA--

    RQCD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RQCD1 (RCD1)

    Search CenterWatch for drugs/clinical trials and news about RQCD1 / RCD1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RQCD1 gene (3 alternative transcripts): 
    NM_001271634.1  NM_001271635.1  NM_005444.2  

    Unigene Cluster for RQCD1:

    RCD1 required for cell differentiation1 homolog (S. pombe)
    Hs.148767  [show with all ESTs]
    Unigene Representative Sequence: NM_001271634
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273064 ENST00000433439 ENST00000432877 ENST00000295701(uc002vih.1)
    ENST00000489687 ENST00000473626 ENST00000418808 ENST00000509807(uc010zki.2)
    ENST00000542068(uc010zkh.2)
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    Additional mRNA sequence: 

    AK293281.1 AK296037.1 AK316567.1 BC007102.1 BC137455.1 BC137456.1 NR_073390.1 

    12 DOTS entries:

    DT.453332  DT.100041901  DT.91763932  DT.100814013  DT.91763931  DT.40281432  DT.428260  DT.120994763 
    DT.75103903  DT.91754652  DT.100814016  DT.95240553 

    24/172 AceView cDNA sequences (see all 172):

    BQ774207 BQ015183 CA426638 BM824320 CA487133 AI300982 AI685273 AW960803 
    AA160724 AI264086 BU617827 AI567462 AW135635 BM713829 NM_005444 AI051222 
    BU615355 CB108753 AI432674 AA987750 AA806815 AW207318 C02312 BM993615 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RQCD1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:                    -                                               -                     
    SP2:                    -                                                                     
    SP3:                                                                                          
    SP4:                                                                    -     -               
    SP5:                                                                                          


    ECgene alternative splicing isoforms for RQCD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RQCD1 expression in normal human tissues (normalized intensities)      RQCD1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTATTTTGA
    RQCD1 Expression
    About this image


    RQCD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal cavity   
     
     Neural Tube (Nervous System)
             Mesencephalic Ventricular Zone

    See RQCD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RQCD1

    SOURCE GeneReport for Unigene cluster: Hs.148767

    UniProtKB/Swiss-Prot: RCD1_HUMAN, Q92600
    Tissue specificity: Detected in spleen, thymus, prostate, testis, ovary and intestine

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RQCD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RQCD1 gene from 10/29 species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rqcd11 , 5 rcd1 (required for cell differentiation) homolog 1 more1, 5 92.2(n)1
    99.67(a)1
      1 (38.54 cM)5
    581841  NM_021383.51  NP_067358.11 
     745060585 
    chicken
    (Gallus gallus)
    Aves RQCD11 RCD1 required for cell differentiation1 homolog (S. more 83.19(n)
    99.56(a)
      424215  NM_001006521.1  NP_001006521.1 
    lizard
    (Anolis carolinensis)
    Reptilia RQCD16
    Uncharacterized protein
    99(a)
    1 ↔ 1
    1(88456066-88469713)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.137612 Xenopus laevis, clone IMAGE5543531, mRNA 80.29(n)    BC044281.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BM141305.12   -- 76.32(n)    BM141305.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG142133
    Rcd-11
    Required for cell differentiation 1 ortholog1 78(a)
    (best of 3)3
    66.79(n)1
    79.57(a)1
      18D113
    329661  NM_134491.21  NP_608335.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C26E6.33
    ntl-91
    cell differentiation family, Rcd1-like3
    Protein NTL-91
    67(a)3
    64.38(n)1
    73.29(a)1
      III(5016328-5019541)3
    1756691  NM_065647.51  NP_498048.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CAF40(YNL288W)4
    CAF401
    Evolutionarily conserved subunit of the CCR4-NOT complex more4
    Caf40p1
    56.26(n)1
    61.71(a)1
      14(90303-91424)4
    8554281, 4  NP_014111.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G208001 CCR4-NOT transcription complex subunit 9 59.75(n)
    67.47(a)
      821628  NM_112971.3  NP_188716.1 
    rice
    (Oryza sativa)
    Liliopsida NM_186338.12   -- 73.79(n)    NM_186338.1 


    ENSEMBL Gene Tree for RQCD1 (if available)
    TreeFam Gene Tree for RQCD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RQCD1 gene
    18/62 SIMAP similar genes for RQCD1 using alignment to 7 protein entries:     RCD1_HUMAN (see all proteins) (see all similar genes):
    HEXDC    C1orf143    CALCOCO2    NEK4    OK/SW-cl.41    TMEM209
    ZNF66    C14orf105    DUSP3    RHBG    PFKFB3    FLJ00047
    FP6651    PUS1    SLMO1    UBE2B    BIRC3    CLTA

    RQCD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/508 SNPs in RQCD1 are shown (see all 508)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1871908281,2
    --219435283(+) GTAACA/GTGGGG 4 -- int10--------
    rs5081571,2
    C,F,O,H--219435288(+) GTGGGG/AAAAAG 4 -- int122Minor allele frequency- A:0.46MN NA NS EA WA 2664
    rs1912548921,2
    --219435494(+) TGCATC/GTTTTA 4 -- int10--------
    rs1830017681,2
    C--219435576(+) CTTACA/C/GTTAAT 4 -- int10--------
    rs1887512121,2
    --219435704(+) AAAACA/GTAAAA 4 -- int10--------
    rs5134481,2
    C,F,H--219435842(+) GCAACA/CGTGCC 4 -- int116Minor allele frequency- C:0.03NS EA NA WA CSA 648
    rs1397123761,2
    --219435904(+) AAGTGC/TGTATC 4 -- int10--------
    rs1497704601,2
    --219435905(+) AGTGTA/GTATCT 4 -- int10--------
    rs1457751381,2
    --219435926(+) TTATCG/TCTTTT 4 -- int10--------
    rs22567451,2
    C,F,H--219436001(+) TAAGCT/CGGGTG 4 -- int117Minor allele frequency- C:0.01NS EA NA WA CSA 794

    HapMap Linkage Disequilibrium report for RQCD1 (219433303 - 219461803 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RQCD1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2721478CNV Deletion23290073
    nsv3168CNV Loss18451855
    nsv875861CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612054    OMIM disorders: --

    2 diseases for RQCD1:    About MalaCards
    breast cancer    prostatitis


    RQCD1 for disorders           About GeneDecksing


    Export disorders for RQCD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RQCD1 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with RQCD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel factor highly conserved among eukaryotes controls sexual development in fission yeast. (PubMed id 9447985)1, 2, 3 Okazaki N....Okayama H. (1998)
    2. Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1. (PubMed id 18180299)1, 2, 9 Garapaty S....Samuels H.H. (2008)
    3. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. C2ORF29/CNOT11 and CNOT10 form a new module of the CCR 4-NOT complex. (PubMed id 23232451)2 Mauxion F....Seraphin B. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis. (PubMed id 20878056)1 Ajiro M....Nakamura Y. (2010)
    10. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9125 HGNC: 10445 AceView: RQCD1 Ensembl:ENSG00000144580 euGenes: HUgn9125
    ECgene: RQCD1 Kegg: 9125 H-InvDB: RQCD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RQCD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RQCD1 gene:
    Search GeneIP for patents involving RQCD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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