Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RQCD1 Gene

protein-coding   GIFtS: 56
GCID: GC02P219433

RCD1 required for cell differentiation1 homolog (S. pombe)

(Previous names: rcd1 (required for cell differentiation, S.pombe) homolog...)
 Explore 3 diseases affiliated with
RQCD1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RQCD1    

Aliases
for RQCD1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
RCD1 Required For Cell Differentiation1 Homolog (S. Pombe)1 2     Rcd1 (Required For Cell Differentiation, S.Pombe) Homolog 11
CNOT91 2 3 5     RCD-12
RCD11 2 3 5     Cancer/Testis Antigen 1292
CT1291 2     Cell Differentiation Protein RCD1 Homolog2
CCR4-NOT Transcription Complex Subunit 92 3     Protein Involved In Sexual Development2
RCD1+1     Rcd-13

External Ids:    HGNC: 104451   Entrez Gene: 91252   Ensembl: ENSG000001445807   OMIM: 6120545   UniProtKB: Q926003   

Export aliases for RQCD1 gene to outside databases

Previous GC identifers: GC02P217449 GC02P218154 GC02P219397 GC02P219636 GC02P219259 GC02P219141 GC02P211286


Summaries
for RQCD1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RQCD1:
This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional
cofactor and a core protein of the CCR4-NOT complex. It may be involved in signal transduction as well as retinoic
acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for
this gene. (provided by RefSeq, Oct 2012)

UniProtKB/Swiss-Prot: RCD1_HUMAN, Q92600
Function: Transcription factor that down-regulates MYB- and JUN-dependent transcription. May play a role in cell
differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the
physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional
activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly
increased, if at all




Genomic Views
for RQCD1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RQCD1 gene promoter:
         SRF   AML1a   SRF (504 AA)   HNF-3beta   Nkx6-1   E2F-1   E2F   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RQCD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RQCD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RQCD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

RQCD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RQCD1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P219433:  view genomic region     (about GC identifiers)

Start:
 219,433,303 bp from pter      End:
 219,461,803 bp from pter
Size:
 28,501 bases      Orientation:
 plus strand

Proteins
for RQCD1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RCD1_HUMAN, Q92600 (See protein sequence)
Recommended Name: Cell differentiation protein RCD1 homolog  
Size: 299 amino acids; 33631 Da
Subunit: Homodimer. Interacts with MYB, ATF2, RARA, RARB, RARG, RXRA, RXRB and RXRG. Identified in a complex with ATF2
bound to target DNA (By similarity). Interacts with NANOS2 (By similarity). Directly interacts with ZNF335
Subcellular location: Nucleus (By similarity). Cytoplasm, P-body (By similarity). Note=NANOS2 promotes its localization
to P-body (By similarity)
Sequence caution: Sequence=AAH07102.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for RQCD1:
2FV2 (3D)    
Secondary accessions: B2RPI0 Q96IX4

Explore the universe of human proteins at neXtProt for RQCD1: NX_Q92600

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92600

    • RQCD1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001258563.1  NP_001258564.1  NP_005435.1  

    ENSEMBL proteins: 
     ENSP00000273064   ENSP00000415607   ENSP00000392394   ENSP00000295701   ENSP00000396938  
     ENSP00000441357   ENSP00000443687  
    Reactome Protein details: Q92600
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: RQCD1
    OriGene Custom Protein Services for RQCD1 
    GenScript Custom Purified and Recombinant Proteins Services for RQCD1
    Novus Biologicals RQCD1 Proteins
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for RQCD1
    Uscn Proteins for RQCD1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body ISS--
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--


    RQCD1 for ontologies           About GeneDecksing



    RQCD1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RQCD1 
    GenScript Custom Superior Antibodies Services for RQCD1
    Novus Biologicals RQCD1 Antibody
    Search for Antibodies for RQCD1 at Abcam  
    Uscn Antibodies for RQCD1
    Search ThermoFisher Antibodies for RQCD1

    Assay Products for RQCD1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RQCD1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RQCD1

    Protein Domains /
    Families
    for RQCD1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RQCD1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011989 ARM-like
     IPR007216 Rcd1
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q92600

    ProtoNet protein and cluster: Q92600

    UniProtKB/Swiss-Prot: RCD1_HUMAN, Q92600
    Similarity: Belongs to the RCD1 family


    Function
    for RQCD1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RCD1_HUMAN, Q92600
    Function: Transcription factor that down-regulates MYB- and JUN-dependent transcription. May play a role in cell
    differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the
    physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional
    activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly
    increased, if at all

    miRNA
    Products:            		miRTarBase miRNAs that target RQCD1:
    hsa-mir-30a (MIRT005206)

    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RQCD1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RQCD1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RQCD1 (see all 7)
    OriGene shRNA RFP: RQCD1
    OriGene siRNA: RQCD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RQCD1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RQCD1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RQCD1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RQCD1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RQCD1 (NM_005444)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RQCD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RQCD1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for RQCD1
    Search LifeMap BioReagents cell lines for RQCD1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RQCD1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18180299


    RQCD1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for RQCD1:
     Synthetic lethal with Ras 

    Animal Models:
         5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Rqcd1):
     embryogenesis  homeostasis/metabolism  mortality/aging  nervous system  no phenotypic analysis 

    RQCD1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RQCD1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Deadenylation-dependent mRNA decay
    		Deadenylation-dependent mRNA decay1.00
    		Deadenylation of mRNA0.47
    		RNA degradation0.50
    2Metabolism of mRNA
    		Metabolism of mRNA1.00
    		Metabolism of RNA0.92
    3Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for RQCD1
        Deadenylation of mRNA
    Deadenylation-dependent mRNA decay
    Metabolism of RNA
    Metabolism of mRNA
    Gene Expression


    1         Kegg Pathway  (Kegg details for RQCD1):
        RNA degradation


    RQCD1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RQCD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/108 Interacting proteins for RQCD1 (Q926002, 3 ENSP000002730644) via UniProtKB, MINT, STRING, and/or I2D (see all 108)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3MINT-48431 I2D: score=2 
    CNOT6Q9ULM63, ENSP000002619514I2D: score=7 STRING: ENSP00000261951
    CNOT1A5YKK63, ENSP000003209494STRING: ENSP00000320949 I2D: score=6 
    CNOT8Q9UFF93, ENSP000002858964I2D: score=5 STRING: ENSP00000285896
    CNOT3O751753, ENSP000002212324I2D: score=4 STRING: ENSP00000221232
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007548sex differentiation TAS9447985


    RQCD1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RQCD1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RQCD1
    Search CenterWatch for drugs/clinical trials and news about RQCD1 / RCD1 

    Transcripts
    for RQCD1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RQCD1 gene (3 alternative transcripts): 
    NM_001271634.1  NM_001271635.1  NM_005444.2  

    Unigene Cluster for RQCD1:

    RCD1 required for cell differentiation1 homolog (S. pombe)
    Hs.148767  [show with all ESTs]
    Unigene Representative Sequence: NM_001271634
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273064 ENST00000433439 ENST00000432877 ENST00000295701(uc002vih.1)
    ENST00000489687 ENST00000473626 ENST00000418808 ENST00000509807(uc010zki.2)
    ENST00000542068(uc010zkh.2)

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RQCD1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RQCD1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RQCD1 (see all 7)
    OriGene shRNA RFP: RQCD1
    OriGene siRNA: RQCD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RQCD1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RQCD1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RQCD1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RQCD1 (NM_005444)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RQCD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RQCD1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RQCD1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RQCD1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RQCD1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RQCD1

    Additional cDNA sequence: 

    AK293281.1 AK296037.1 AK316567.1 BC007102.1 BC137455.1 BC137456.1 NR_073390.1 

    12 DOTS entries:

    DT.453332  DT.100041901  DT.91763932  DT.100814013  DT.91763931  DT.40281432  DT.428260  DT.120994763 
    DT.75103903  DT.91754652  DT.100814016  DT.95240553 

    24/172 AceView cDNA sequences (see all 172):

    CA314814 BQ000907 BM676889 H61129 BU617827 AA987750 AA806815 BQ774207 
    AW207318 CA426638 AA876303 AA337845 BU615355 BM993615 AW135635 BM713829 
    AI369159 CB161632 CA487133 BM824320 R88396 AI300982 AA478093 AA160724 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RQCD1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:                    -                                               -                     
    SP2:                    -                                                                     
    SP3:                                                                                          
    SP4:                                                                    -     -               
    SP5:                                                                                          


    ECgene alternative splicing isoforms for RQCD1

    Expression
    for RQCD1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RQCD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTATTTTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RQCD1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RQCD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RQCD1

    SOURCE GeneReport for Unigene cluster: Hs.148767

    UniProtKB/Swiss-Prot: RCD1_HUMAN, Q92600
    Tissue specificity: Detected in spleen, thymus, prostate, testis, ovary and intestine

        SABiosciences Custom PCR Arrays for RQCD1
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RQCD1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RQCD1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RQCD1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RQCD1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RQCD1

    Orthologs
    for RQCD1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RQCD1 gene from 10/39 species (see all 39)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rqcd11 , 5 rcd1 (required for cell differentiation) homolog 1 more1, 5 92.2(n)1
    99.67(a)1    		   1 (38.54 cM)5
    581841  NM_021383.51  NP_067358.11 
     745060585 
    chicken
    (Gallus gallus)    		 Aves RQCD11 RCD1 required for cell differentiation1 homolog (S. more 83.19(n)
    99.56(a)    		   424215  NM_001006521.1  NP_001006521.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RQCD16
    		 --
    		 99(a)
    		 1 ↔ 1
    		 1(88456066-88469355)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.137612 Xenopus laevis, clone IMAGE5543531, mRNA 80.29(n)    BC044281.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BM141305.12   -- 76.32(n)    BM141305.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG142133
    Rcd-11    		 Required for cell differentiation 1 ortholog1 78(a)
    (best of 3)3
    66.79(n)1
    79.57(a)1    		   18D113
    329661  NM_134491.21  NP_608335.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea C26E6.33
    ntl-91    		 cell differentiation family, Rcd1-like3
    Protein NTL-91    		 67(a)3
    64.38(n)1
    73.29(a)1    		   III(5016328-5019541)3
    1756691  NM_065647.51  NP_498048.21 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes CAF40(YNL288W)4
    CAF401    		 Evolutionarily conserved subunit of the CCR4-NOT complex more4
    Caf40p1    		 56.26(n)1
    61.71(a)1    		   14(90303-91424)4
    8554281, 4  NP_014111.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G208001 CCR4-NOT transcription complex subunit 9 59.75(n)
    67.47(a)    		   821628  NM_112971.3  NP_188716.1 
    rice
    (Oryza sativa)    		 Liliopsida NM_186338.12   -- 73.79(n)    NM_186338.1 


    ENSEMBL Gene Tree for RQCD1 (if available)
    TreeFam Gene Tree for RQCD1 (if available) 

    Paralogs
    for RQCD1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for RQCD1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/497 NCBI SNPs in RQCD1 are shown (see all 497)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1879690431,2
    		--219431926(+) CTTTTA/GTATCA 5 -- int1 us2k10--------
    rs1168055141,2
    		--219431976(+) GAATGC/TAACAC 5 -- int1 us2k11Minor allele frequency- T:0.01NA 120
    rs5810131,2
    		C,F,O,A,H,--219432040(+) AAACAT/GCAGGA 5 -- us2k1 int113Minor allele frequency- G:0.19NA WA CSA EA 379
    rs1918817201,2
    		--219432057(+) CAATGC/TTCCAT 5 -- us2k1 int10--------
    rs6604321,2
    		C,F,A,H,--219432127(+) GGCTTC/TAATTA 5 -- us2k1 int18Minor allele frequency- T:0.49NA WA EA 372
    rs1837352241,2
    		--219432139(+) TATCAA/CTATGG 5 -- int1 us2k10--------
    rs1866661261,2
    		--219432169(+) CACACC/TGCGCA 5 -- us2k1 int10--------
    rs1915216991,2
    		--219432170(+) ACACCA/GCGCAC 5 -- us2k1 int10--------
    rs1382278381,2
    		--219432232(+) CAACTA/GCCTAC 5 -- int1 us2k10--------
    rs4718461,2
    		C,F,A,H,--219432237(+) GCCTAC/TTTGAC 5 -- us2k1 int112Minor allele frequency- T:0.23NS EA NA WA 786

    HapMap Linkage Disequilibrium report for RQCD1 (219433303 - 219461803 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RQCD1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RQCD1
    DNA2.0 Custom Variant and Variant Library Synthesis for RQCD1

    Disorders / Diseases
    for RQCD1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RQCD1 for disorders           About GeneDecksing

    OMIM gene information: 612054    OMIM disorders: --

    3 diseases for RQCD1:    About MalaCards
    breast cancer    malaria    prostatitis


    Export disorders for RQCD1 gene to outside databases

    Publications
    for RQCD1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RQCD1 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with RQCD1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel factor highly conserved among eukaryotes controls sexual development in fission yeast. (PubMed id 9447985)1, 2, 3 Okazaki N....Okayama H. (1998)
    2. Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1. (PubMed id 18180299)1, 2, 9 Garapaty S....Samuels H.H. (2008)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis. (PubMed id 20878056)1 Ajiro M....Nakamura Y. (2010)
    8. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    10. Involvement of RQCD1 overexpression, a novel cancer-t estis antigen, in the Akt pathway in breast cancer cells. (PubMed id 19724902)1 Ajiro M....Nakamura Y. (2009)

    External Searches for RQCD1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RQCD1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9125 HGNC: 10445 AceView: RQCD1 Ensembl:ENSG00000144580 euGenes: HUgn9125
    ECgene: RQCD1 Kegg: 9125 H-InvDB: RQCD1

    Other Databases showing RQCD1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RQCD1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RQCD1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RQCD1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RQCD1 gene:
    Search GeneIP for patents involving RQCD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for RQCD1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for RQCD1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RQCD1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RQCD1  
     OriGene Protein Over-expression Lysate for RQCD1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for RQCD1   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RQCD1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RQCD1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RQCD1   OriGene Custom Protein Services for RQCD1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RQCD1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RQCD1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RQCD1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RQCD1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RQCD1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RQCD1
     GenScript Custom Purified and Recombinant Proteins Services for RQCD1 GenScript cDNA clones with any tag delivered in your preferred vector for RQCD1
     GenScript Custom Assay Services for RQCD1 GenScript Custom Superior Antibodies Services for RQCD1
     GenScript Custom overexpressing Cell Line Services for RQCD1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RQCD1 promoter
     Search Chromatin IP Primers for RQCD1
     RT2 qPCR Primer Assay in human, mouse, rat RQCD1
     Search GNC Networks for RQCD1
     SABiosciences Custom PCR Arrays for RQCD1
     Search Tocris compounds for RQCD1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RQCD1 antibodies
     RQCD1 proteins
     Search for Antibodies for RQCD1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for RQCD1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for RQCD1




     RQCD1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for RQCD1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RQCD1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for RQCD1
     SwitchGear Promoter luciferase reporter plasmids for RQCD1
     Search ThermoFisher Antibodies for RQCD1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RQCD1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      RQCD1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4