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Aliases for RPUSD4 Gene

Aliases for RPUSD4 Gene

  • RNA Pseudouridylate Synthase Domain Containing 4 2 3

External Ids for RPUSD4 Gene

Previous GeneCards Identifiers for RPUSD4 Gene

  • GC11M125578
  • GC11M126071
  • GC11M122013

Summaries for RPUSD4 Gene

GeneCards Summary for RPUSD4 Gene

RPUSD4 (RNA Pseudouridylate Synthase Domain Containing 4) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and pseudouridine synthase activity. An important paralog of this gene is RPUSD3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPUSD4 Gene

Genomics for RPUSD4 Gene

Regulatory Elements for RPUSD4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPUSD4 Gene

Chromosome:
11
Start:
126,202,094 bp from pter
End:
126,211,692 bp from pter
Size:
9,599 bases
Orientation:
Minus strand

Genomic View for RPUSD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPUSD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPUSD4 Gene

Proteins for RPUSD4 Gene

  • Protein details for RPUSD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CM3-RUSD4_HUMAN
    Recommended name:
    RNA pseudouridylate synthase domain-containing protein 4
    Protein Accession:
    Q96CM3
    Secondary Accessions:
    • E9PML2
    • Q96K56

    Protein attributes for RPUSD4 Gene

    Size:
    377 amino acids
    Molecular mass:
    42205 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK308059; Type=Frameshift; Positions=101; Evidence={ECO:0000305};

    Alternative splice isoforms for RPUSD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPUSD4 Gene

Proteomics data for RPUSD4 Gene at MOPED

Post-translational modifications for RPUSD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPUSD4 Gene

No data available for DME Specific Peptides for RPUSD4 Gene

Domains & Families for RPUSD4 Gene

Gene Families for RPUSD4 Gene

Suggested Antigen Peptide Sequences for RPUSD4 Gene

Graphical View of Domain Structure for InterPro Entry

Q96CM3

UniProtKB/Swiss-Prot:

RUSD4_HUMAN :
  • Belongs to the pseudouridine synthase RluA family.
Family:
  • Belongs to the pseudouridine synthase RluA family.
genes like me logo Genes that share domains with RPUSD4: view

Function for RPUSD4 Gene

Gene Ontology (GO) - Molecular Function for RPUSD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0005515 protein binding IPI 17577209
GO:0009982 pseudouridine synthase activity IBA --
GO:0019239 contributes_to deaminase activity IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPUSD4: view

Phenotypes for RPUSD4 Gene

GenomeRNAi human phenotypes for RPUSD4:
genes like me logo Genes that share phenotypes with RPUSD4: view

Animal Model Products

miRNA for RPUSD4 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPUSD4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPUSD4 Gene

Localization for RPUSD4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPUSD4 Gene COMPARTMENTS Subcellular localization image for RPUSD4 gene
Compartment Confidence
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RPUSD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
genes like me logo Genes that share ontologies with RPUSD4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPUSD4 Gene

Pathways & Interactions for RPUSD4 Gene

SuperPathways for RPUSD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RPUSD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001522 pseudouridine synthesis --
GO:0009451 RNA modification --
GO:0031119 tRNA pseudouridine synthesis IBA --
genes like me logo Genes that share ontologies with RPUSD4: view

No data available for Pathways by source and SIGNOR curated interactions for RPUSD4 Gene

Drugs & Compounds for RPUSD4 Gene

(1) Additional Compounds for RPUSD4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pseudouridine
  • 5-(b-D-Ribofuranosyl)uracil
  • 5-(b-delta-Ribofuranosyl)uracil
  • 5-b-D-Ribofuranosyl-Uracil
  • 5-beta-delta-Ribofuranosyl-Uracil
  • 5-Ribosyluracil
1445-07-4
genes like me logo Genes that share compounds with RPUSD4: view

Transcripts for RPUSD4 Gene

Unigene Clusters for RPUSD4 Gene

RNA pseudouridylate synthase domain containing 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPUSD4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPUSD4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b
SP1: - - -
SP2: - - - - -
SP3: - - - - - - - - -
SP4: -
SP5:
SP6: - - - - - -
SP7:
SP8: - - - - - - - - - -

Relevant External Links for RPUSD4 Gene

GeneLoc Exon Structure for
RPUSD4
ECgene alternative splicing isoforms for
RPUSD4

Expression for RPUSD4 Gene

mRNA expression in normal human tissues for RPUSD4 Gene

mRNA differential expression in normal tissues according to GTEx for RPUSD4 Gene

This gene is overexpressed in Muscle - Skeletal (x7.2).

Protein differential expression in normal tissues from HIPED for RPUSD4 Gene

This gene is overexpressed in Pancreas (34.8), Lung (24.6), and Adrenal (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPUSD4 Gene



SOURCE GeneReport for Unigene cluster for RPUSD4 Gene Hs.150458

genes like me logo Genes that share expression patterns with RPUSD4: view

Protein tissue co-expression partners for RPUSD4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RPUSD4 Gene

Orthologs for RPUSD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPUSD4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPUSD4 35
  • 84.75 (n)
  • 78.99 (a)
RPUSD4 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPUSD4 35
  • 85.23 (n)
  • 80.37 (a)
RPUSD4 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpusd4 35
  • 82.32 (n)
  • 78.51 (a)
Rpusd4 16
Rpusd4 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPUSD4 35
  • 99.47 (n)
  • 99.47 (a)
RPUSD4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpusd4 35
  • 81.87 (n)
  • 79.58 (a)
oppossum
(Monodelphis domestica)
Mammalia RPUSD4 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPUSD4 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPUSD4 35
  • 64.24 (n)
  • 61.08 (a)
RPUSD4 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPUSD4 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC734064 35
  • 56 (n)
  • 50.37 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10103 35
zebrafish
(Danio rerio)
Actinopterygii rpusd4 35
  • 57.02 (n)
  • 49.69 (a)
rpusd4 36
  • 44 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3295 36
  • 25 (a)
OneToMany
Species with no ortholog for RPUSD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPUSD4 Gene

ENSEMBL:
Gene Tree for RPUSD4 (if available)
TreeFam:
Gene Tree for RPUSD4 (if available)

Paralogs for RPUSD4 Gene

Paralogs for RPUSD4 Gene

genes like me logo Genes that share paralogs with RPUSD4: view

Variants for RPUSD4 Gene

Sequence variations from dbSNP and Humsavar for RPUSD4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs480153 -- 126,202,399(+) AGATA(C/T)GCTTC utr-variant-3-prime
rs486669 -- 126,208,049(+) CACAG(G/T)GGCAA intron-variant
rs510767 -- 126,208,390(+) AAACT(C/G/T)TGTGT intron-variant
rs534804 -- 126,205,873(+) CTTCT(A/G)CACTA intron-variant
rs535644 -- 126,205,948(+) GCTGA(C/T)AGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPUSD4 Gene

Variant ID Type Subtype PubMed ID
nsv536 CNV Loss 18451855

Variation tolerance for RPUSD4 Gene

Residual Variation Intolerance Score: 58.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.11; 90.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPUSD4 Gene

HapMap Linkage Disequilibrium report
RPUSD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPUSD4 Gene

Disorders for RPUSD4 Gene

Relevant External Links for RPUSD4

Genetic Association Database (GAD)
RPUSD4
Human Genome Epidemiology (HuGE) Navigator
RPUSD4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPUSD4
genes like me logo Genes that share disorders with RPUSD4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPUSD4 Gene

Publications for RPUSD4 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 67
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 67
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz A.G. … Landthaler M. (Mol. Cell 2012) 67

Products for RPUSD4 Gene

Sources for RPUSD4 Gene

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