Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPUSD4 Gene

Aliases for RPUSD4 Gene

  • RNA Pseudouridylate Synthase Domain Containing 4 2 3

External Ids for RPUSD4 Gene

Previous GeneCards Identifiers for RPUSD4 Gene

  • GC11M125578
  • GC11M126071
  • GC11M122013

Summaries for RPUSD4 Gene

GeneCards Summary for RPUSD4 Gene

RPUSD4 (RNA Pseudouridylate Synthase Domain Containing 4) is a Protein Coding gene. GO annotations related to this gene include RNA binding and pseudouridine synthase activity. An important paralog of this gene is RPUSD3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPUSD4 Gene

Genomics for RPUSD4 Gene

Regulatory Elements for RPUSD4 Gene

Genomic Location for RPUSD4 Gene

Start:
126,202,094 bp from pter
End:
126,211,692 bp from pter
Size:
9,599 bases
Orientation:
Minus strand

Genomic View for RPUSD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPUSD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPUSD4 Gene

Proteins for RPUSD4 Gene

  • Protein details for RPUSD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CM3-RUSD4_HUMAN
    Recommended name:
    RNA pseudouridylate synthase domain-containing protein 4
    Protein Accession:
    Q96CM3
    Secondary Accessions:
    • E9PML2
    • Q96K56

    Protein attributes for RPUSD4 Gene

    Size:
    377 amino acids
    Molecular mass:
    42205 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK308059; Type=Frameshift; Positions=101; Evidence={ECO:0000305};

    Alternative splice isoforms for RPUSD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPUSD4 Gene

Proteomics data for RPUSD4 Gene at MOPED

Post-translational modifications for RPUSD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPUSD4 Gene

No data available for DME Specific Peptides for RPUSD4 Gene

Domains for RPUSD4 Gene

Gene Families for RPUSD4 Gene

HGNC:
  • RPUSD :RNA pseudouridylate synthase domain containing

Suggested Antigen Peptide Sequences for RPUSD4 Gene

Graphical View of Domain Structure for InterPro Entry

Q96CM3

UniProtKB/Swiss-Prot:

RUSD4_HUMAN :
  • Q96CM3
Family:
  • Belongs to the pseudouridine synthase RluA family.
genes like me logo Genes that share domains with RPUSD4: view

Function for RPUSD4 Gene

Gene Ontology (GO) - Molecular Function for RPUSD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0005515 protein binding IPI 17577209
GO:0009982 pseudouridine synthase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPUSD4: view

miRNA for RPUSD4 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPUSD4 Gene

Localization for RPUSD4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPUSD4 Gene COMPARTMENTS Subcellular localization image for RPUSD4 gene
Compartment Confidence
mitochondrion 3
nucleus 1

Gene Ontology (GO) - Cellular Components for RPUSD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with RPUSD4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPUSD4 Gene

Pathways for RPUSD4 Gene

SuperPathways for RPUSD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RPUSD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001522 pseudouridine synthesis IEA --
GO:0009451 RNA modification --
genes like me logo Genes that share ontologies with RPUSD4: view

No data available for Pathways by source for RPUSD4 Gene

Compounds for RPUSD4 Gene

(1) HMDB Compounds for RPUSD4 Gene

Compound Synonyms Cas Number PubMed IDs
Pseudouridine
  • 5-(b-D-Ribofuranosyl)uracil
1445-07-4
genes like me logo Genes that share compounds with RPUSD4: view

Transcripts for RPUSD4 Gene

Unigene Clusters for RPUSD4 Gene

RNA pseudouridylate synthase domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPUSD4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b
SP1: - - -
SP2: - - - - -
SP3: - - - - - - - - -
SP4: -
SP5:
SP6: - - - - - -
SP7:
SP8: - - - - - - - - - -

Relevant External Links for RPUSD4 Gene

GeneLoc Exon Structure for
RPUSD4
ECgene alternative splicing isoforms for
RPUSD4

Expression for RPUSD4 Gene

mRNA expression in normal human tissues for RPUSD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RPUSD4 Gene

This gene is overexpressed in Muscle - Skeletal (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPUSD4 Gene

SOURCE GeneReport for Unigene cluster for RPUSD4 Gene Hs.150458

genes like me logo Genes that share expressions with RPUSD4: view

No data available for mRNA Expression by UniProt/SwissProt for RPUSD4 Gene

Orthologs for RPUSD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPUSD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPUSD4 35
  • 99.47 (n)
  • 99.47 (a)
RPUSD4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPUSD4 35
  • 84.75 (n)
  • 78.99 (a)
RPUSD4 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPUSD4 35
  • 85.23 (n)
  • 80.37 (a)
RPUSD4 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpusd4 35
  • 82.32 (n)
  • 78.51 (a)
Rpusd4 16
Rpusd4 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPUSD4 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPUSD4 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpusd4 35
  • 81.87 (n)
  • 79.58 (a)
chicken
(Gallus gallus)
Aves RPUSD4 35
  • 64.24 (n)
  • 61.08 (a)
RPUSD4 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPUSD4 36
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10103 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC734064 35
  • 56 (n)
  • 50.37 (a)
zebrafish
(Danio rerio)
Actinopterygii rpusd4 35
  • 57.02 (n)
  • 49.69 (a)
rpusd4 36
  • 44 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3295 36
  • 25 (a)
OneToMany
Species with no ortholog for RPUSD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPUSD4 Gene

ENSEMBL:
Gene Tree for RPUSD4 (if available)
TreeFam:
Gene Tree for RPUSD4 (if available)

Paralogs for RPUSD4 Gene

Paralogs for RPUSD4 Gene

genes like me logo Genes that share paralogs with RPUSD4: view

Variants for RPUSD4 Gene

Sequence variations from dbSNP and Humsavar for RPUSD4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs480153 -- 126,202,399(+) AGATA(C/T)GCTTC utr-variant-3-prime
rs486669 -- 126,208,049(+) CACAG(G/T)GGCAA intron-variant
rs510767 -- 126,208,390(+) AAACT(C/G/T)TGTGT intron-variant
rs534804 -- 126,205,873(+) CTTCT(A/G)CACTA intron-variant
rs535644 -- 126,205,948(+) GCTGA(C/T)AGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPUSD4 Gene

Variant ID Type Subtype PubMed ID
nsv536 CNV Loss 18451855

Relevant External Links for RPUSD4 Gene

HapMap Linkage Disequilibrium report
RPUSD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPUSD4 Gene

Disorders for RPUSD4 Gene

Relevant External Links for RPUSD4

Genetic Association Database (GAD)
RPUSD4
Human Genome Epidemiology (HuGE) Navigator
RPUSD4
genes like me logo Genes that share disorders with RPUSD4: view

No data available for UniProtKB/Swiss-Prot for RPUSD4 Gene

Publications for RPUSD4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. Identification of new mechanisms of cellular response to chemotherapy by tracking changes in post-translational modifications by ubiquitin and ubiquitin-like proteins. (PMID: 24654937) Bonacci T. … Soubeyran P. (J. Proteome Res. 2014) 3

Products for RPUSD4 Gene

Sources for RPUSD4 Gene

Back to Top

Content