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Aliases for RPUSD3 Gene

Aliases for RPUSD3 Gene

  • RNA Pseudouridylate Synthase Domain Containing 3 2 3 5

External Ids for RPUSD3 Gene

Previous GeneCards Identifiers for RPUSD3 Gene

  • GC03M009855
  • GC03M009856
  • GC03M009817
  • GC03M009879

Summaries for RPUSD3 Gene

GeneCards Summary for RPUSD3 Gene

RPUSD3 (RNA Pseudouridylate Synthase Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and pseudouridine synthase activity. An important paralog of this gene is RPUSD4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPUSD3 Gene

Genomics for RPUSD3 Gene

Regulatory Elements for RPUSD3 Gene

Promoters for RPUSD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPUSD3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPUSD3 Gene

Chromosome:
3
Start:
9,837,849 bp from pter
End:
9,844,602 bp from pter
Size:
6,754 bases
Orientation:
Minus strand

Genomic View for RPUSD3 Gene

Genes around RPUSD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPUSD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPUSD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPUSD3 Gene

Proteins for RPUSD3 Gene

  • Protein details for RPUSD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P087-RUSD3_HUMAN
    Recommended name:
    RNA pseudouridylate synthase domain-containing protein 3
    Protein Accession:
    Q6P087
    Secondary Accessions:
    • B4DS39
    • Q6P6A9
    • Q8N1B2
    • Q8NAV3

    Protein attributes for RPUSD3 Gene

    Size:
    351 amino acids
    Molecular mass:
    38461 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH62362.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH65741.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RPUSD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPUSD3 Gene

Proteomics data for RPUSD3 Gene at MOPED

Post-translational modifications for RPUSD3 Gene

  • Ubiquitination at Lys 68
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for RPUSD3 Gene

Domains & Families for RPUSD3 Gene

Gene Families for RPUSD3 Gene

Protein Domains for RPUSD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q6P087

UniProtKB/Swiss-Prot:

RUSD3_HUMAN :
  • Belongs to the pseudouridine synthase RluA family.
Family:
  • Belongs to the pseudouridine synthase RluA family.
genes like me logo Genes that share domains with RPUSD3: view

Function for RPUSD3 Gene

Gene Ontology (GO) - Molecular Function for RPUSD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0009982 pseudouridine synthase activity IEA,IBA --
GO:0019239 contributes_to deaminase activity IBA --
genes like me logo Genes that share ontologies with RPUSD3: view

Phenotypes for RPUSD3 Gene

genes like me logo Genes that share phenotypes with RPUSD3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RPUSD3

miRNA for RPUSD3 Gene

miRTarBase miRNAs that target RPUSD3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPUSD3 Gene

Localization for RPUSD3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPUSD3 Gene COMPARTMENTS Subcellular localization image for RPUSD3 gene
Compartment Confidence
mitochondrion 4
nucleus 3
cytosol 2
endoplasmic reticulum 1
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RPUSD3 Gene

Pathways & Interactions for RPUSD3 Gene

SuperPathways for RPUSD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RPUSD3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RPUSD3 Gene

Drugs & Compounds for RPUSD3 Gene

(1) Additional Compounds for RPUSD3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pseudouridine
  • 5-(b-D-Ribofuranosyl)uracil
  • 5-(b-delta-Ribofuranosyl)uracil
  • 5-b-D-Ribofuranosyl-Uracil
  • 5-beta-delta-Ribofuranosyl-Uracil
  • 5-Ribosyluracil
1445-07-4
genes like me logo Genes that share compounds with RPUSD3: view

Transcripts for RPUSD3 Gene

Unigene Clusters for RPUSD3 Gene

RNA pseudouridylate synthase domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPUSD3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - - - - - - -
SP9: - - -
SP10: - - - - - - - - -
SP11: - -
SP12: - - -
SP13: - - -
SP14: -
SP15: - -
SP16: -

ExUns: 11b · 11c · 11d ^ 12a · 12b · 12c
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - - -
SP9:
SP10:
SP11:
SP12: - - -
SP13:
SP14:
SP15:
SP16:

Relevant External Links for RPUSD3 Gene

GeneLoc Exon Structure for
RPUSD3
ECgene alternative splicing isoforms for
RPUSD3

Expression for RPUSD3 Gene

mRNA expression in normal human tissues for RPUSD3 Gene

Protein differential expression in normal tissues from HIPED for RPUSD3 Gene

This gene is overexpressed in Lung (52.2) and Breast (14.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RPUSD3 Gene



SOURCE GeneReport for Unigene cluster for RPUSD3 Gene Hs.33719

genes like me logo Genes that share expression patterns with RPUSD3: view

Protein tissue co-expression partners for RPUSD3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPUSD3 Gene

Orthologs for RPUSD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPUSD3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPUSD3 35
  • 84.06 (n)
  • 81.34 (a)
RPUSD3 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPUSD3 35
  • 85.75 (n)
  • 80.63 (a)
RPUSD3 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpusd3 35
  • 78.04 (n)
  • 72.89 (a)
Rpusd3 16
Rpusd3 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPUSD3 35
  • 92.77 (n)
  • 92.08 (a)
RPUSD3 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpusd3 35
  • 77.32 (n)
  • 73.67 (a)
oppossum
(Monodelphis domestica)
Mammalia RPUSD3 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPUSD3 36
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPUSD3 35
  • 57.4 (n)
  • 49.11 (a)
lizard
(Anolis carolinensis)
Reptilia RPUSD3 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpusd3 35
  • 53.26 (n)
  • 45.77 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3147 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3295 36
  • 17 (a)
OneToMany
Species with no ortholog for RPUSD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RPUSD3 Gene

ENSEMBL:
Gene Tree for RPUSD3 (if available)
TreeFam:
Gene Tree for RPUSD3 (if available)

Paralogs for RPUSD3 Gene

Paralogs for RPUSD3 Gene

genes like me logo Genes that share paralogs with RPUSD3: view

Variants for RPUSD3 Gene

Sequence variations from dbSNP and Humsavar for RPUSD3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs17855991 - 9,843,915(+) TGCGT(C/G)CTCGG reference, missense
rs34244989 -, - 9,840,591(+) AGAAG(C/G)AGCTG reference, missense
rs2426 -- 9,841,337(+) GAGAC(A/G)GGGTC intron-variant
rs1133340 -- 9,841,346(-) CCTGA(A/G)TGAGA intron-variant
rs2290306 -- 9,843,931(+) GGGCG(C/G)ACACC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for RPUSD3 Gene

Variant ID Type Subtype PubMed ID
nsv834615 CNV Loss 17160897

Variation tolerance for RPUSD3 Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPUSD3 Gene

HapMap Linkage Disequilibrium report
RPUSD3
Human Gene Mutation Database (HGMD)
RPUSD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPUSD3 Gene

Disorders for RPUSD3 Gene

Relevant External Links for RPUSD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPUSD3

No disorders were found for RPUSD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPUSD3 Gene

Publications for RPUSD3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. A systems-wide screen identifies substrates of the SCFI^TrCP ubiquitin ligase. (PMID: 25515538) Low T.Y. … Heck A.J. (Sci Signal 2014) 3

Products for RPUSD3 Gene

Sources for RPUSD3 Gene

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