RPUSD2 Gene
protein-coding GIFtS: 44
GCID: GC15P040861
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RNA pseudouridylate synthase domain containing 2(Previous name: chromosome 15 open reading frame 19 )
(Previous symbol: C15orf19)
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Aliases
for RPUSD2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RNA Pseudouridylate Synthase Domain Containing 21 2 | | Chromosome 15 Open Reading Frame 191 | | C15orf191 2 3 | | C18B11 Homolog (44.9kD)2 | | C18B111 2 | | RNA Pseudouridylate Synthase Domain-Containing Protein 22 | | FLJ314091 | | |
Export aliases for RPUSD2 gene to outside databasesPrevious GC identifers: GC15P038649 GC15P017708 |
Summaries
for RPUSD2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RPUSD2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RPUSD2 gene promoter:
Egr-3 C/EBPbeta Pax-5 Tal-1beta E47 MEF-2A HEN1 HFH-1 aMEF-2 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RPUSD2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPUSD2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q13.3 Ensembl cytogenetic band: 15q15.1 HGNC cytogenetic band: 15q13.3RPUSD2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P040861: view genomic region
(about GC identifiers)
Start:
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40,861,499 bp from pter |
End:
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40,866,661 bp from pter |
Size:
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5,163 bases |
Orientation:
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plus strand |
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Proteins
for RPUSD2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RUSD2_HUMAN, Q8IZ73 (See
protein sequence)Recommended Name: RNA pseudouridylate synthase domain-containing protein 2 Size: 545 amino acids; 61311 Da
Sequence caution: Sequence=AAB07777.1; Type=Frameshift; Positions=494, 497;
Secondary accessions: Q7L989 Q92939 Q96IA7 Q96N50Explore the universe of human proteins at neXtProt for RPUSD2: NX_Q8IZ73
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IZ73
RPUSD2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689473.1
ENSEMBL proteins: ENSP00000323288 ENSP00000453036
Human Recombinant Protein Products for RPUSD2:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
RPUSD2 for ontologies About GeneDecksing
RPUSD2 Antibody Products:
Assay Products for RPUSD2: |
Protein
Domains /
Families
for RPUSD2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPUSD2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IZ73ProtoNet protein and cluster: Q8IZ73 1 Blocks protein family: IPB006224 Pseudouridine synthase
UniProtKB/Swiss-Prot: RUSD2_HUMAN, Q8IZ73Similarity: Belongs to the pseudouridine synthase RluA family |
Function
for RPUSD2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
RPUSD2 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPUSD2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPUSD2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RPUSD2 (NM_152260) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPUSD2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPUSD2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPUSD2 |
|
Pathways & Interactions
for RPUSD2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPUSD2
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/14 Interacting proteins for RPUSD2 (Q8IZ733 ENSP000003232884) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001522 | pseudouridine synthesis |
IEA | -- | | GO:0008150 | biological_process |
ND | -- |
RPUSD2 for ontologies About GeneDecksing
|
Drugs & Compounds
for RPUSD2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RPUSD2
1 HMDB Compound for RPUSD2 About this table
Search CenterWatch for drugs/clinical trials and news about RPUSD2 / RUSD2
|
Transcripts
for RPUSD2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RPUSD2 gene: NM_152260.1 Unigene Cluster for RPUSD2: RNA pseudouridylate synthase domain containing 2 Hs.173311 [show with all ESTs]Unigene Representative Sequence: BC0169672 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000315616(uc021sjh.1 uc001zmd.1) ENST00000559271
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPUSD2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPUSD2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RPUSD2 (NM_152260) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPUSD2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPUSD2 |
Additional cDNA sequence: AK055971.1 AK293145.1 AK301383.1 AK301706.1 BC007697.1 BC016967.1 2 DOTS entries: DT.212162 DT.91760453 24/94 AceView cDNA sequences (see all 94): BX281342 CR624718 CB144393 AA232194 BI831271 BX097963 BC016967 BM699145 BC007697 AL529117 AW025973 NM_152260 CR608473 CR597785 BQ054975 BM684008 AI499001 AW751147 AK055971 BX389974 BG389393 BG471838 BE796026 AI571208
GeneLoc Exon Structure
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Expression
for RPUSD2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RPUSD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RPUSD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPUSD2
SOURCE GeneReport for Unigene cluster: Hs.173311
SABiosciences Custom PCR Arrays for RPUSD2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPUSD2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RPUSD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPUSD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPUSD2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPUSD2 |
Orthologs
for RPUSD2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for RPUSD2 gene from 10/33 species (see all 33) About this table
ENSEMBL Gene Tree for RPUSD2 (if available)
TreeFam Gene Tree for RPUSD2 (if available) |
Paralogs
for RPUSD2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RPUSD2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RPUSD2 (40861499 - 40866661 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RPUSD2
2 CNVs: 47928 3959 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPUSD2 |
|
Disorders
/ Diseases
for RPUSD2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPUSD2 for disorders About GeneDecksing
3  diseases for RPUSD2: About MalaCardspneumonia tuberculosis mycobacterium tuberculosis
Export disorders for RPUSD2 gene to outside databases
|
Publications
for RPUSD2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RPUSD2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RPUSD2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for RPUSD2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing RPUSD2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RPUSD2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RPUSD2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RPUSD2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for RPUSD2 gene:
Search GeneIP for patents involving RPUSD2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RPUSD2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPUSD2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPUSD2 | | | OriGene Protein Over-expression Lysate for RPUSD2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RPUSD2 | | OriGene 3'-UTR Clone for RPUSD2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPUSD2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPUSD2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RPUSD2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPUSD2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPUSD2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPUSD2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPUSD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPUSD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPUSD2 |
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| | | | Search Tocris compounds for RPUSD2 |
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 | | | RPUSD2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPUSD2 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for RPUSD2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPUSD2 |
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