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Aliases for RPUSD2 Gene

Aliases for RPUSD2 Gene

  • RNA Pseudouridylate Synthase Domain Containing 2 2 3
  • C15orf19 3 4
  • RNA Pseudouridylate Synthase Domain-Containing Protein 2 3
  • Chromosome 15 Open Reading Frame 19 2
  • C18B11 Homolog (44.9kD) 3
  • C18B11 3

External Ids for RPUSD2 Gene

Previous HGNC Symbols for RPUSD2 Gene

  • C15orf19

Previous GeneCards Identifiers for RPUSD2 Gene

  • GC15P038649
  • GC15P040861
  • GC15P017708

Summaries for RPUSD2 Gene

GeneCards Summary for RPUSD2 Gene

RPUSD2 (RNA Pseudouridylate Synthase Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include RNA binding and pseudouridine synthase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPUSD2 Gene

Genomics for RPUSD2 Gene

Regulatory Elements for RPUSD2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPUSD2 Gene

Start:
40,569,293 bp from pter
End:
40,574,943 bp from pter
Size:
5,651 bases
Orientation:
Plus strand

Genomic View for RPUSD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPUSD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPUSD2 Gene

Proteins for RPUSD2 Gene

  • Protein details for RPUSD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZ73-RUSD2_HUMAN
    Recommended name:
    RNA pseudouridylate synthase domain-containing protein 2
    Protein Accession:
    Q8IZ73
    Secondary Accessions:
    • B4DDD1
    • Q7L989
    • Q92939
    • Q96IA7
    • Q96N50

    Protein attributes for RPUSD2 Gene

    Size:
    545 amino acids
    Molecular mass:
    61311 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB07777.1; Type=Frameshift; Positions=494, 497; Evidence={ECO:0000305};

    Alternative splice isoforms for RPUSD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPUSD2 Gene

Proteomics data for RPUSD2 Gene at MOPED

Post-translational modifications for RPUSD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPUSD2 Gene

No data available for DME Specific Peptides for RPUSD2 Gene

Domains for RPUSD2 Gene

Gene Families for RPUSD2 Gene

HGNC:
  • RPUSD :RNA pseudouridylate synthase domain containing

Suggested Antigen Peptide Sequences for RPUSD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IZ73

UniProtKB/Swiss-Prot:

RUSD2_HUMAN :
  • Q8IZ73
Family:
  • Belongs to the pseudouridine synthase RluA family.
genes like me logo Genes that share domains with RPUSD2: view

Function for RPUSD2 Gene

Gene Ontology (GO) - Molecular Function for RPUSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0009982 pseudouridine synthase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPUSD2: view

Animal Model Products

CRISPR Products

miRNA for RPUSD2 Gene

miRTarBase miRNAs that target RPUSD2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPUSD2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPUSD2 Gene

Localization for RPUSD2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPUSD2 Gene COMPARTMENTS Subcellular localization image for RPUSD2 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPUSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with RPUSD2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPUSD2 Gene

Pathways for RPUSD2 Gene

SuperPathways for RPUSD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RPUSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001522 pseudouridine synthesis IEA --
GO:0008150 biological_process ND --
GO:0009451 RNA modification --
genes like me logo Genes that share ontologies with RPUSD2: view

No data available for Pathways by source for RPUSD2 Gene

Compounds for RPUSD2 Gene

(1) HMDB Compounds for RPUSD2 Gene

Compound Synonyms Cas Number PubMed IDs
Pseudouridine
  • 5-(b-D-Ribofuranosyl)uracil
1445-07-4
genes like me logo Genes that share compounds with RPUSD2: view

Transcripts for RPUSD2 Gene

mRNA/cDNA for RPUSD2 Gene

Unigene Clusters for RPUSD2 Gene

RNA pseudouridylate synthase domain containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPUSD2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RPUSD2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPUSD2 Gene

No ASD Table

Relevant External Links for RPUSD2 Gene

GeneLoc Exon Structure for
RPUSD2
ECgene alternative splicing isoforms for
RPUSD2

Expression for RPUSD2 Gene

mRNA expression in normal human tissues for RPUSD2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPUSD2 Gene

SOURCE GeneReport for Unigene cluster for RPUSD2 Gene Hs.173311

genes like me logo Genes that share expressions with RPUSD2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPUSD2 Gene

Orthologs for RPUSD2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPUSD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPUSD2 35
  • 99.63 (n)
  • 99.27 (a)
RPUSD2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPUSD2 35
  • 84.51 (n)
  • 83.02 (a)
RPUSD2 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPUSD2 35
  • 86.12 (n)
  • 84.4 (a)
RPUSD2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpusd2 35
  • 81.98 (n)
  • 79.07 (a)
Rpusd2 16
Rpusd2 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPUSD2 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPUSD2 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPUSD2 35
  • 75.22 (n)
  • 78.32 (a)
RPUSD2 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPUSD2 36
  • 56 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.29407 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19049 35
zebrafish
(Danio rerio)
Actinopterygii LOC565088 35
  • 61.56 (n)
  • 61.71 (a)
rpusd2 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RluA-1 36
  • 31 (a)
OneToMany
RluA-2 35
  • 53.45 (n)
  • 51.2 (a)
RluA-2 36
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K07E8.7 36
  • 35 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUS9 36
  • 34 (a)
OneToMany
RIB2 36
  • 28 (a)
OneToMany
RIB2 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
-- 36
  • 27 (a)
OneToMany
Species with no ortholog for RPUSD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPUSD2 Gene

ENSEMBL:
Gene Tree for RPUSD2 (if available)
TreeFam:
Gene Tree for RPUSD2 (if available)

Paralogs for RPUSD2 Gene

No data available for Paralogs for RPUSD2 Gene

Variants for RPUSD2 Gene

Sequence variations from dbSNP and Humsavar for RPUSD2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1058734 -- 40,569,865(+) CTGGC(C/T)TACTA intron-variant, reference, synonymous-codon
rs1453182 -- 40,567,351(+) TACCT(C/T)TTGGG upstream-variant-2KB
rs1453183 -- 40,570,731(+) ATTTG(C/T)GTCAA intron-variant
rs2412525 -- 40,574,923(-) ttata(A/T)aaaat downstream-variant-500B
rs2959540 -- 40,569,880(+) GCCGC(C/G)GTCCG intron-variant, synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for RPUSD2 Gene

Variant ID Type Subtype PubMed ID
esv34145 CNV Loss 18971310
nsv832984 CNV Loss 17160897
dgv739e1 CNV Complex 17122850

Relevant External Links for RPUSD2 Gene

HapMap Linkage Disequilibrium report
RPUSD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPUSD2 Gene

Disorders for RPUSD2 Gene

No disorders were found for RPUSD2 Gene.

No data available for UniProtKB/Swiss-Prot for RPUSD2 Gene

Publications for RPUSD2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PMID: 17474147) Wu C. … Li S.S. (Proteomics 2007) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for RPUSD2 Gene

Sources for RPUSD2 Gene

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