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Aliases for RPUSD2 Gene

Aliases for RPUSD2 Gene

  • RNA Pseudouridylate Synthase Domain Containing 2 2 3 5
  • C15orf19 3 4
  • RNA Pseudouridylate Synthase Domain-Containing Protein 2 3
  • Chromosome 15 Open Reading Frame 19 2
  • C18B11 Homolog (44.9kD) 3
  • C18B11 3

External Ids for RPUSD2 Gene

Previous HGNC Symbols for RPUSD2 Gene

  • C15orf19

Previous GeneCards Identifiers for RPUSD2 Gene

  • GC15P038649
  • GC15P040861
  • GC15P017708

Summaries for RPUSD2 Gene

GeneCards Summary for RPUSD2 Gene

RPUSD2 (RNA Pseudouridylate Synthase Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and pseudouridine synthase activity.

Additional gene information for RPUSD2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPUSD2 Gene

Genomics for RPUSD2 Gene

Regulatory Elements for RPUSD2 Gene

Enhancers for RPUSD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H040519 1.2 Ensembl ENCODE 11.2 -49.3 -49290 0.6 HDGF ATF1 ZNF121 ZNF143 KLF7 ATF7 RUNX3 MCM3 REST PPARG CHST14 INO80 RPUSD2 CCDC32 ENSG00000259211 DNAJC17 BAHD1 BMF RPLP0P10 PLCB2
GH15H040592 1.2 ENCODE 11 +25.0 24975 2.7 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF207 CCDC32 INO80 ENSG00000259211 RPAP1 BAHD1 RTF1 DNAJC17 RPUSD2 EIF2AK4 BMF
GH15H040742 1.3 Ensembl ENCODE 10 +176.6 176631 7.4 PKNOX1 FOXA2 ATF1 ARID4B SIN3A TCF12 ZNF121 ZNF766 ELK1 ZNF143 CCDC32 RAD51 C15orf62 DNAJC17 ZFYVE19 RAD51-AS1 SPINT1 RHOV VPS18 ENSG00000251161
GH15H040785 1.3 Ensembl ENCODE dbSUPER 9.7 +218.2 218221 4.4 CTCF NFIB ZIC2 RAD21 CTBP1 GATA3 POLR2A FOS PRDM10 RUNX3 ZFYVE19 CCDC32 RMDN3 GCHFR SPINT1 RAD51 RAD51-AS1 RHOV VPS18 ENSG00000251161
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPUSD2 on UCSC Golden Path with GeneCards custom track

Promoters for RPUSD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000075539 307 1601 HDGF ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS

Genomic Locations for RPUSD2 Gene

Genomic Locations for RPUSD2 Gene
5,651 bases
Plus strand

Genomic View for RPUSD2 Gene

Genes around RPUSD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPUSD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPUSD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPUSD2 Gene

Proteins for RPUSD2 Gene

  • Protein details for RPUSD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA pseudouridylate synthase domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B4DDD1
    • Q7L989
    • Q92939
    • Q96IA7
    • Q96N50

    Protein attributes for RPUSD2 Gene

    545 amino acids
    Molecular mass:
    61311 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB07777.1; Type=Frameshift; Positions=494, 497; Evidence={ECO:0000305};

    Alternative splice isoforms for RPUSD2 Gene


neXtProt entry for RPUSD2 Gene

Post-translational modifications for RPUSD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPUSD2 Gene

No data available for DME Specific Peptides for RPUSD2 Gene

Domains & Families for RPUSD2 Gene

Gene Families for RPUSD2 Gene

Suggested Antigen Peptide Sequences for RPUSD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the pseudouridine synthase RluA family.
  • Belongs to the pseudouridine synthase RluA family.
genes like me logo Genes that share domains with RPUSD2: view

Function for RPUSD2 Gene

Phenotypes From GWAS Catalog for RPUSD2 Gene

Gene Ontology (GO) - Molecular Function for RPUSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0009982 pseudouridine synthase activity IBA --
GO:0019239 contributes_to deaminase activity IBA --
genes like me logo Genes that share ontologies with RPUSD2: view

Phenotypes for RPUSD2 Gene

genes like me logo Genes that share phenotypes with RPUSD2: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPUSD2 Gene

Localization for RPUSD2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPUSD2 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPUSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with RPUSD2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPUSD2 Gene

Pathways & Interactions for RPUSD2 Gene

SuperPathways for RPUSD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RPUSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000455 enzyme-directed rRNA pseudouridine synthesis IBA --
GO:0001522 pseudouridine synthesis IEA --
GO:0008150 biological_process ND --
GO:0009451 RNA modification IEA --
genes like me logo Genes that share ontologies with RPUSD2: view

No data available for Pathways by source and SIGNOR curated interactions for RPUSD2 Gene

Drugs & Compounds for RPUSD2 Gene

(1) Additional Compounds for RPUSD2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5-(b-D-Ribofuranosyl)uracil
  • 5-(b-delta-Ribofuranosyl)uracil
  • 5-b-D-Ribofuranosyl-Uracil
  • 5-beta-delta-Ribofuranosyl-Uracil
  • 5-Ribosyluracil
genes like me logo Genes that share compounds with RPUSD2: view

Transcripts for RPUSD2 Gene

Unigene Clusters for RPUSD2 Gene

RNA pseudouridylate synthase domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPUSD2 Gene

No ASD Table

Relevant External Links for RPUSD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPUSD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPUSD2 Gene

Protein differential expression in normal tissues from HIPED for RPUSD2 Gene

This gene is overexpressed in CD8 Tcells (13.0), Lymph node (12.2), Peripheral blood mononuclear cells (11.4), and Testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPUSD2 Gene

Protein tissue co-expression partners for RPUSD2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPUSD2 Gene:


SOURCE GeneReport for Unigene cluster for RPUSD2 Gene:


Evidence on tissue expression from TISSUES for RPUSD2 Gene

  • Lung(4.2)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with RPUSD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPUSD2 Gene

Orthologs for RPUSD2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPUSD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPUSD2 33 34
  • 99.63 (n)
(Canis familiaris)
Mammalia RPUSD2 34 33
  • 86.12 (n)
(Ornithorhynchus anatinus)
Mammalia RPUSD2 34
  • 86 (a)
(Bos Taurus)
Mammalia RPUSD2 34 33
  • 84.51 (n)
(Mus musculus)
Mammalia Rpusd2 16 34 33
  • 81.98 (n)
(Monodelphis domestica)
Mammalia RPUSD2 34
  • 69 (a)
(Gallus gallus)
Aves RPUSD2 33 34
  • 75.22 (n)
(Anolis carolinensis)
Reptilia RPUSD2 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19049 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.29407 33
(Danio rerio)
Actinopterygii LOC565088 33
  • 61.56 (n)
rpusd2 34
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta RluA-2 33 34
  • 53.45 (n)
RluA-1 34
  • 31 (a)
(Caenorhabditis elegans)
Secernentea K07E8.7 34
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUS9 34
  • 34 (a)
RIB2 34 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
-- 34
  • 27 (a)
Species where no ortholog for RPUSD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPUSD2 Gene

Gene Tree for RPUSD2 (if available)
Gene Tree for RPUSD2 (if available)

Paralogs for RPUSD2 Gene

No data available for Paralogs for RPUSD2 Gene

Variants for RPUSD2 Gene

Sequence variations from dbSNP and Humsavar for RPUSD2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1001100168 -- 40,572,658(+) CCATG(A/G)GAGGT intron-variant
rs1001541998 -- 40,571,073(+) CTGCA(A/G)CCTCC intron-variant
rs1001811025 -- 40,568,318(+) AGAGG(G/T)TTAAA upstream-variant-2KB
rs1001883335 -- 40,568,568(+) AAAAG(C/G)CTTGG upstream-variant-2KB
rs1002151269 -- 40,574,625(+) TCAAG(A/G/T)TTAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RPUSD2 Gene

Variant ID Type Subtype PubMed ID
nsv832984 CNV loss 17160897
esv34145 CNV loss 18971310
esv2760026 CNV loss 17122850

Variation tolerance for RPUSD2 Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPUSD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPUSD2 Gene

Disorders for RPUSD2 Gene

Relevant External Links for RPUSD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPUSD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPUSD2 Gene

Publications for RPUSD2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 60

Products for RPUSD2 Gene

Sources for RPUSD2 Gene

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