RPTOR Gene
protein-coding GIFtS: 62
GCID: GC17P078518
|
|
regulatory associated protein of MTOR, complex 1
| |
Aliases
for RPTOR gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Regulatory Associated Protein Of MTOR, Complex 11 2 | | RAPTOR3 5 | | KIAA13031 3 5 | | P150 Target Of Rapamycin (TOR)-Scaffold Protein Containing WD-Repeats2 | | KOG11 2 | | Regulatory-Associated Protein Of MTOR2 | | Mip11 2 | | Raptor3 | | Raptor3 | | P150 Target Of Rapamycin (TOR)-Scaffold Protein3 |
Export aliases for RPTOR gene to outside databasesPrevious GC identifers: GC17P076135 GC17P073954 |
Summaries
for RPTOR gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RPTOR:
This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulinlevels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryoticinitiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates thedownstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcriptvariants encoding different isoforms have been found for this gene. (provided by RefSeq, Sep 2009)
UniProtKB/Swiss-Prot: RPTOR_HUMAN, Q8N122Function: Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cellgrowth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold forrecruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growthfactor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to theactivation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling tomTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. ActivatedmTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis.mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 andtargeting it for degradation
Gene Wiki entry for RPTOR (KIAA1303)
|
Genomic Views
for RPTOR gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for RPTOR
Other transcription factors
Search SABiosciences Chromatin IP Primers for RPTOR
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPTOR |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25.3RPTOR Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P078518: view genomic region
(about GC identifiers)
Start:
|
78,518,619 bp from pter |
End:
|
78,940,173 bp from pter |
Size:
|
421,555 bases |
Orientation:
|
plus strand |
|
Proteins
for RPTOR gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RPTOR_HUMAN, Q8N122 (See
protein sequence)Recommended Name: Regulatory-associated protein of mTOR Size: 1335 amino acids; 149038 Da
Subunit: Interacts with MTOR (By similarity). Part of the mammalian target of rapamycin complex 1 (mTORC1) whichcontains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Bindsdirectly to 4EBP1 and RPS6KB1 independently of its association with MTOR. Binds preferentially to poorly ornon-phosphorylated forms of EIF4EBP1, and this binding is critical to the ability of MTOR to catalyze phosphorylation.Forms a complex with MTOR under both leucine-rich and -poor conditions. Interacts with ULK1 in a nutrient-dependentmanner; the interaction is reduced during starvation. Interacts (when phosphorylated by AMPK) with 14-3-3 protein,leading to inhibit its activity
Subcellular location: Cytoplasm. Lysosome. Note=Targeting to lysosomes depends on amino acid availability
Secondary accessions: B2RN36 Q8N4V9 Q8TB32 Q9P2P3Alternative splicing: 2 isoforms: Q8N122-1 Q8N122-2 Explore the universe of human proteins at neXtProt for RPTOR: NX_Q8N122
Post-translational modifications:
Insulin-stimulated phosphorylation at Ser-863 by MTOR and MAPK8 up-regulates mTORC1 activity. Osmotic stress alsoinduces phosphorylation at Ser-696, Thr-706 and Ser-863 by MAPK8. Ser-863 phosphorylation is required forphosphorylation at Ser-855 and Ser-859. In response to nutrient limitation, phosphorylated by AMPK; phosphorylationpromotes interaction with 14-3-3 proteins, leading to negative regulation of the mTORC1 complex. In response to growthfactors, phosphorylated at Ser-719, Ser-721 and Ser-722 by RPS6KA1, which stimulates mTORC1 activity1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N122
RPTOR Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001156506.1 NP_065812.1
ENSEMBL proteins: ENSP00000459701 ENSP00000460136 ENSP00000307272 ENSP00000442479 ENSP00000460940 ENSP00000440947 Reactome Protein details: Q8N122
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
RPTOR for ontologies About GeneDecksing
RPTOR Antibody Products:
Assay Products for RPTOR: |
Protein
Domains /
Families
for RPTOR gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPTOR for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q8N122ProtoNet protein and cluster: Q8N122 2 Blocks protein families: IPB000357 HEAT repeat IPB004083 Saccharomyces cerevisiae 175.8kDa hypothetical protein signature
UniProtKB/Swiss-Prot: RPTOR_HUMAN, Q8N122Similarity: Belongs to the WD repeat RAPTOR familySimilarity: Contains 7 WD repeats |
Function
for RPTOR gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RPTOR_HUMAN, Q8N122Function: Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cellgrowth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold forrecruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growthfactor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to theactivation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling tomTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. ActivatedmTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis.mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 andtargeting it for degradation
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPTOR (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for RPTOR | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPTOR |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPTOR |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001030 | RNA polymerase III type 1 promoter DNA binding |
IDA | -- | | GO:0001031 | RNA polymerase III type 2 promoter DNA binding |
IDA | -- | | GO:0001032 | RNA polymerase III type 3 promoter DNA binding |
IDA | -- | | GO:0001156 | TFIIIC-class transcription factor binding |
IDA | -- | | GO:0005515 | protein binding |
IPI | -- |
RPTOR for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RPTOR:
Animal Models:
Mouse knock-outs for RPTOR: Rptortm1Lex Rptortm1.1Rueg
14 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Rptor):
RPTOR for phenotypes About GeneDecksing
|
Pathways & Interactions
for RPTOR gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | IRS-related events | | | 2 | mTOR signalling | | | 3 | mTORC1-mediated signalling | | | 4 | Energy dependent regulation of mTOR by LKB1-AMPK | | | 5 | Development_CNTF receptor signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Cell Signaling Technology (CST) Pathways for RPTOR
5  BioSystems Pathways for RPTOR
5/16 
Reactome Pathways for RPTOR (see all 16)
2 
Kegg Pathways (Kegg details for RPTOR):
RPTOR for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPTOR
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/96 Interacting proteins for RPTOR (Q8N1221, 2, 3 ENSP000003072724) via UniProtKB, MINT, STRING, and/or I2D (see all 96)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| EIF4EBP1 | Q135411, 2, 3, ENSP000003406914 | EBI-1567928,EBI-74090 MINT-6549354 I2D:
score=5 STRING: ENSP00000340691 | | RICTOR | Q6R3272, 3, ENSP000003499594 | MINT-7556024 MINT-8150419 I2D:
score=2 STRING: ENSP00000349959 | | MLST8 | Q9BVC41, 3, ENSP000003718884 | EBI-1567928,EBI-1567843 I2D:
score=7 STRING: ENSP00000371888 | | MTOR | P423451, 2, 3, ENSP000003545584 | EBI-1567928,EBI-359260 MINT-7556099 MINT-7222801 MINT-7556024 MINT-8088311 MINT-8150419 I2D:
score=12 STRING: ENSP00000354558 | | MAPKAP1 | Q9BPZ72, 3, ENSP000002659604 | MINT-7556024 MINT-8150419 I2D:
score=1 STRING: ENSP00000265960 |
About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
RPTOR for ontologies About GeneDecksing
|
Drugs & Compounds
for RPTOR gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RPTOR for compounds About GeneDecksing
 Browse Tocris compounds for RPTOR
2 Novoseek chemical compound relationships for RPTOR gene About this table
Search CenterWatch for drugs/clinical trials and news about RPTOR
|
Transcripts
for RPTOR gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RPTOR gene (2 alternative transcripts): NM_001163034.1 NM_020761.2 Unigene Cluster for RPTOR: Regulatory associated protein of MTOR, complex 1 Hs.133044 [show with all ESTs]Unigene Representative Sequence: NM_02076112 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000574767 ENST00000577161 ENST00000570891(uc002jys.3) ENST00000306801(uc002jyt.1 uc010wug.1)
ENST00000544334 ENST00000573746 ENST00000572733 ENST00000575542(uc002jyu.1)
ENST00000576366 ENST00000573837 ENST00000573163 ENST00000537330(uc010wuf.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPTOR (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPTOR (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): RPTOR (NM_020761) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RPTOR | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPTOR |
Additional cDNA sequence: AB037724.1 AB082951.1 AK055912.1 AK295964.1 AK296321.1 AY090663.1 BC014502.1 BC025180.1 BC033258.1 BC033699.1 BC041079.1 BC064515.1 BC073898.1 BC136652.1 BC136654.1 GQ183898.1 9 DOTS entries: DT.413296 DT.100749451 DT.100836007 DT.100758660 DT.65285420 DT.100001522 DT.95274834 DT.95274839 DT.97772244 24/165 AceView cDNA sequences (see all 165): BM718442 BU187764 AB082951 AI028378 BM474228 BM809091 BM556894 CR608664 AA629126 BM455531 BM854064 CA310481 BC073898 BC064515 BM680224 BM914430 CF272460 BM725017 BU153684 BM981742 CA426914 AI479004 AI933619 BP365193
GeneLoc Exon Structure
|
Expression
for RPTOR gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RPTOR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RPTOR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RPTOR
SOURCE GeneReport for Unigene cluster: Hs.133044
UniProtKB/Swiss-Prot: RPTOR_HUMAN, Q8N122Tissue specificity: Highly expressed in skeletal muscle, and in a lesser extent in brain, lung, small intestine, kidneyand placenta
SABiosciences Expression via Pathway-Focused PCR Array including RPTOR:
Primer
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Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPTOR |
Orthologs
for RPTOR gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RPTOR gene from 10/32 species (see all 32) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Rptor1 , 5 |
regulatory associated protein of MTOR, complex 11, 5 |
87.44(n)1
96.63(a)1 |
|
11 (83.96 cM)5
743701 NM_028898.21 NP_083174.21
1196029055 |
chicken
(Gallus gallus) |
Aves |
RPTOR1 |
regulatory associated protein of MTOR, complex 1 |
82.92(n)
95.06(a) |
|
428674 XM_426232.3 XP_426232.2 |
lizard
(Anolis carolinensis) |
Reptilia |
---- |
-- |
95(a)91(a) |
many → 1many → 1 |
2(99854456-100048351) 2(99753322-99804756) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.120672 |
Transcribed sequence with weak similarity to protein more |
74.41(n) |
|
BX704129.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
rptor1 |
regulatory associated protein of MTOR, complex 1 |
74.81(n)
88.2(a) |
|
560455 XM_001919253.1 XP_001919288.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
raptor1 |
CG4320-PA |
54.33(n)
50.12(a) |
|
31543 NM_132066.1 NP_572294.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
daf-156 |
abnormal DAuer Formation family member (daf-15) |
23(a) |
1 ↔ 1 |
IV(9386191-9394905) |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
KOG1(YHR186C)4
KOG11 |
Subunit of TORC1, a rapamycin-sensitive complex involved more4
Kog1p1 |
45.04(n)1
39.68(a)1 |
|
8(480672-475999)4
8565931, 4 NP_012056.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
RAPTOR11 |
regulatory associated protein of mTOR |
50.29(n)
46.49(a) |
|
820032 NM_111719.2 NP_566335.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.37402 |
Oryza sativa (japonica cultivar-group) mRNA for dsRNA-binding more |
73.07(n) |
|
AY491431.1 |
ENSEMBL Gene Tree for RPTOR (if available)
TreeFam Gene Tree for RPTOR (if available) |
Paralogs
for RPTOR gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RPTOR gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RPTOR (78518619 - 78768619 bp, first 250kb of RPTOR)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 43 variations for RPTOR
15/16 CNVs (see all 16): 73071 73068 102559 73072 77756 88646 73067 77753 88651 73069 23533 102557 73056 73059 88650
15/27 Indels (see all 27): 77760 25940 25949 77761 88653 60249 102558 88652 25943 77759 88655 25942 45608 77754 77757 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPTOR |
|
Disorders
/ Diseases
for RPTOR gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPTOR for disorders About GeneDecksing
OMIM gene information: 607130
OMIM disorders: --
9  diseases for RPTOR: About MalaCardslens subluxation cytomegalovirus infection moyamoya disease psoriatic arthritis
tuberous sclerosis arthritis prostate cancer prostatitis
hepatitis
1 disease from the University of Copenhagen DISEASES database for RPTOR:Lens subluxation Human Genome Epidemiology (HuGE) Navigator: RPTOR (0 documents)
Export disorders for RPTOR gene to outside databases
|
Publications
for RPTOR gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RPTOR gene, integrated from 9 sources (see all 118):
(articles sorted by number of sources associating them with RPTOR) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. (PubMed id 12150926)1, 2, 3, 9 Hara K.... Yonezawa K. (2002)
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
- Regulation of mTOR complex 1 (mTORC1) by raptor Ser86 3 and multisite phosphorylation. (PubMed id 19864431)1, 2, 9 Foster K.G....Fingar D.C. (2010)
- Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation. (PubMed id 18722121)1, 2, 9 Carriere A....Roux P.P. (2008)
- Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function. (PubMed id 15066126)1, 2, 9 Oshiro N.... Yonezawa K. (2004)
- mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the growth machinery. (PubMed id 12150925)1, 2, 9 Kim D.-H.... Sabatini D.M. (2002)
- Osmotic stress regulates mammalian target of rapamycin (mTOR) complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor protein phos phorylation. (PubMed id 22493283)1, 2 Kwak D....Ryu S.H. (2012)
- Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. (PubMed id 19211835)1, 2 Hosokawa N....Mizushima N. (2009)
- AMPK phosphorylation of raptor mediates a metabolic checkpoint. (PubMed id 18439900)1, 2 Gwinn D.M....Shaw R.J. (2008)
- PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. (PubMed id 17386266)1, 2 Sancak Y....Sabatini D.M. (2007)
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External Searches for RPTOR gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing RPTOR gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing RPTOR gene
(According to HUGE)
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Specialized Databases showing RPTOR gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for RPTOR | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for RPTOR gene:
Search GeneIP for patents involving RPTOR
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RPTOR gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for RPTOR | | OriGene shRNA RFP for RPTOR | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RPTOR | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RPTOR | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RPTOR | | OriGene 3'-UTR Clone for RPTOR | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RPTOR | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RPTOR | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RPTOR | | OriGene Custom Protein Services for RPTOR | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RPTOR | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RPTOR | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RPTOR | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RPTOR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RPTOR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RPTOR |
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| | Antibodies & Assays for RPTOR (raptor) |
| | | | Search Tocris compounds for RPTOR |
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 | | | RPTOR Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RPTOR |
|  |  |  | | | | ThermoFisher Antibody for RPTOR |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RPTOR |
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