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Aliases for RPSAP58 Gene

Aliases for RPSAP58 Gene

  • Ribosomal Protein SA Pseudogene 58 2 3
  • RPSA_30_1642 3

External Ids for RPSAP58 Gene

Previous GeneCards Identifiers for RPSAP58 Gene

  • GC19U901020
  • GC19P023946
  • GC19P023490

Summaries for RPSAP58 Gene

GeneCards Summary for RPSAP58 Gene

RPSAP58 (Ribosomal Protein SA Pseudogene 58) is a Pseudogene. Diseases associated with RPSAP58 include chronic wasting disease. Among its related pathways are Immune System and Infectious disease. GO annotations related to this gene include structural constituent of ribosome and laminin receptor activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPSAP58 Gene

Genomics for RPSAP58 Gene

Regulatory Elements for RPSAP58 Gene

Genomic Location for RPSAP58 Gene

23,763,014 bp from pter
23,828,135 bp from pter
65,122 bases
Plus strand

Genomic View for RPSAP58 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for RPSAP58 Gene

Proteins for RPSAP58 Gene

  • Protein details for RPSAP58 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein SA
    Protein Accession:

    Protein attributes for RPSAP58 Gene

    295 amino acids
    Molecular mass:
    32909 Da
    Quaternary structure:
    • Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
    • This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.
  • Protein details for RPSAP58 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein RPSAP58
    Protein Accession:

    Protein attributes for RPSAP58 Gene

    73 amino acids
    Molecular mass:
    8250 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RPSAP58 Gene

Proteomics data for RPSAP58 Gene at MOPED

Post-translational modifications for RPSAP58 Gene

  • Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
  • Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.

No data available for DME Specific Peptides for RPSAP58 Gene

Domains & Families for RPSAP58 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RPSAP58: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RPSAP58 Gene

Function for RPSAP58 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for RPSAP58 Gene

Localization for RPSAP58 Gene

Subcellular locations from

Jensen Localization Image for RPSAP58 Gene COMPARTMENTS Subcellular localization image for RPSAP58 gene
Compartment Confidence
extracellular 2
cytoskeleton 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RPSAP58 Gene

Pathways & Interactions for RPSAP58 Gene

SuperPathways for RPSAP58 Gene

Superpath Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Cytokine production by Th17 cells in CF
4 Toll-like receptor signaling pathway
5 Bacterial infections in CF airways
genes like me logo Genes that share pathways with RPSAP58: view

Interacting Proteins for RPSAP58 Gene

Gene Ontology (GO) - Biological Process for RPSAP58 Gene


No data available for SIGNOR curated interactions for RPSAP58 Gene

Drugs & Compounds for RPSAP58 Gene

No Compound Related Data Available

Transcripts for RPSAP58 Gene

mRNA/cDNA for RPSAP58 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2931) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPSAP58 Gene

Ribosomal protein SA pseudogene 58:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPSAP58 Gene

No ASD Table

Relevant External Links for RPSAP58 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPSAP58 Gene

mRNA expression in normal human tissues for RPSAP58 Gene

Protein differential expression in normal tissues from HIPED for RPSAP58 Gene

This gene is overexpressed in Skin (41.1), Heart (17.0), and Saliva (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from for RPSAP58 Gene

SOURCE GeneReport for Unigene cluster for RPSAP58 Gene Hs.560655

genes like me logo Genes that share expression patterns with RPSAP58: view

Protein tissue co-expression partners for RPSAP58 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPSAP58 Gene

Orthologs for RPSAP58 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPSAP58 Gene

Organism Taxonomy Gene Similarity Type Details
(Danio rerio)
Actinopterygii zgc55831 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.508 35
(Glycine max)
eudicotyledons Gma.3328 35
Species with no ortholog for RPSAP58:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPSAP58 Gene

Gene Tree for RPSAP58 (if available)
Gene Tree for RPSAP58 (if available)

Paralogs for RPSAP58 Gene

(2) SIMAP similar genes for RPSAP58 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RPSAP58: view

No data available for Paralogs for RPSAP58 Gene

Variants for RPSAP58 Gene

Sequence variations from dbSNP and Humsavar for RPSAP58 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1134225 -- 23,813,129(-) ttctc(C/T)caagt intron-variant
rs4283347 -- 23,811,350(+) TGTTA(C/T)ATAAC intron-variant
rs4287706 -- 23,800,203(+) tattt(A/T)atttt intron-variant
rs4293508 -- 23,800,873(+) cccca(A/G)agtgc intron-variant
rs4387719 -- 23,770,564(+) TGTGA(A/C)ATATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPSAP58 Gene

Variant ID Type Subtype PubMed ID
esv2751784 CNV Gain 17911159
nsv911466 CNV Gain 21882294
nsv524183 CNV Gain 19592680
esv2718381 CNV Deletion 23290073
dgv3821n71 CNV Gain 21882294
nsv911474 CNV Loss 21882294
esv2670676 CNV Deletion 23128226
esv4296 CNV Complex 18987735
esv2619335 CNV Deletion 19546169
esv2268001 CNV Deletion 18987734
esv9336 CNV Loss 19470904
esv2718383 CNV Deletion 23290073
nsv138127 CNV Loss 16902084
dgv556e201 CNV Deletion 23290073
esv2677185 CNV Deletion 23128226
esv2718386 CNV Deletion 23290073
nsv138104 CNV Loss 16902084
nsv2448 CNV Insertion 18451855

Variation tolerance for RPSAP58 Gene

Gene Damage Index Score: 11.48; 92.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPSAP58 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPSAP58 Gene

Disorders for RPSAP58 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPSAP58 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chronic wasting disease
  • wasting disease, chronic
- elite association

Relevant External Links for RPSAP58

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPSAP58: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPSAP58 Gene

Publications for RPSAP58 Gene

  1. Comparative analysis of processed ribosomal protein pseudogenes in four mammalian genomes. (PMID: 19123937) Balasubramanian S. … Gerstein M. (Genome Biol. 2009) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 67
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for RPSAP58 Gene

Sources for RPSAP58 Gene

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