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Aliases for RPSAP58 Gene

Aliases for RPSAP58 Gene

  • Ribosomal Protein SA Pseudogene 58 2 3
  • RPSA_30_1642 3

External Ids for RPSAP58 Gene

Previous GeneCards Identifiers for RPSAP58 Gene

  • GC19U901020
  • GC19P023946
  • GC19P023490

Summaries for RPSAP58 Gene

GeneCards Summary for RPSAP58 Gene

RPSAP58 (Ribosomal Protein SA Pseudogene 58) is a Pseudogene. Among its related pathways are Disease and IL6-mediated signaling events. An important paralog of this gene is RPSA.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPSAP58 Gene

Genomics for RPSAP58 Gene

Regulatory Elements for RPSAP58 Gene

Genomic Location for RPSAP58 Gene

Start:
23,763,005 bp from pter
End:
23,828,135 bp from pter
Size:
65,131 bases
Orientation:
Plus strand

Genomic View for RPSAP58 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPSAP58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPSAP58 Gene

Proteins for RPSAP58 Gene

  • Protein details for RPSAP58 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A6NE09
    Recommended name:
    40S ribosomal protein SA
    Protein Accession:
    A6NE09
    Secondary Accessions:

    Protein attributes for RPSAP58 Gene

    Size:
    295 amino acids
    Molecular mass:
    32909 Da
    Quaternary structure:
    • Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
    Miscellaneous:
    • This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.
  • Protein details for RPSAP58 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    C9JQR9
    Recommended name:
    Protein RPSAP58
    Protein Accession:
    C9JQR9
    Secondary Accessions:

    Protein attributes for RPSAP58 Gene

    Size:
    73 amino acids
    Molecular mass:
    8250 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RPSAP58 Gene

Proteomics data for RPSAP58 Gene at MOPED

Post-translational modifications for RPSAP58 Gene

  • Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
  • Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.

Other Protein References for RPSAP58 Gene

No data available for DME Specific Peptides for RPSAP58 Gene

Domains for RPSAP58 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RPSAP58: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RPSAP58 Gene

Function for RPSAP58 Gene

Gene Ontology (GO) - Molecular Function for RPSAP58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome --
GO:0005055 laminin receptor activity --
GO:0043236 laminin binding --
genes like me logo Genes that share ontologies with RPSAP58: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RPSAP58 Gene

Localization for RPSAP58 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPSAP58 Gene COMPARTMENTS Subcellular localization image for RPSAP58 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RPSAP58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005840 ribosome --
GO:0005886 plasma membrane --
GO:0015935 small ribosomal subunit --
genes like me logo Genes that share ontologies with RPSAP58: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPSAP58 Gene

Pathways for RPSAP58 Gene

SuperPathways for RPSAP58 Gene

Superpath Contained pathways
1 Influenza Viral RNA Transcription and Replication
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Cytokine production by Th17 cells in CF
4 Toll-like receptor signaling pathway
5 Bacterial infections in CF airways
genes like me logo Genes that share pathways with RPSAP58: view

Interacting Proteins for RPSAP58 Gene

Gene Ontology (GO) - Biological Process for RPSAP58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000028 ribosomal small subunit assembly --
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) --
GO:0000461 endonucleolytic cleavage to generate mature 3-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) --
GO:0006407 rRNA export from nucleus --
GO:0006412 translation --
genes like me logo Genes that share ontologies with RPSAP58: view

Transcripts for RPSAP58 Gene

mRNA/cDNA for RPSAP58 Gene

Unigene Clusters for RPSAP58 Gene

Ribosomal protein SA pseudogene 58:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPSAP58

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPSAP58 Gene

No ASD Table

Relevant External Links for RPSAP58 Gene

GeneLoc Exon Structure for
RPSAP58
ECgene alternative splicing isoforms for
RPSAP58

Expression for RPSAP58 Gene

mRNA expression in normal human tissues for RPSAP58 Gene

Protein differential expression in normal tissues for RPSAP58 Gene

This gene is overexpressed in Skin (41.1), Heart (17.0), and Saliva (6.8).

Integrated Proteomics: protein expression from PaxDb for RPSAP58 Gene

SOURCE GeneReport for Unigene cluster for RPSAP58 Gene Hs.560655

genes like me logo Genes that share expressions with RPSAP58: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPSAP58 Gene

Orthologs for RPSAP58 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPSAP58 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPSA 36
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 72 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Rpsa 36
  • 98 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RPSAP58 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPSA 36
  • 97 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 87 (a)
ManyToMany
-- 36
  • 91 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii zgc55831 35
rpsa 36
  • 88 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.508 35
fruit fly
(Drosophila melanogaster)
Insecta sta 36
  • 53 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rps-0 36
  • 56 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS0A 36
  • 55 (a)
ManyToMany
RPS0B 36
  • 56 (a)
ManyToMany
soybean
(Glycine max)
eudicotyledons Gma.3328 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
ManyToMany
CSA.5233 36
  • 66 (a)
ManyToMany
Species with no ortholog for RPSAP58:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPSAP58 Gene

ENSEMBL:
Gene Tree for RPSAP58 (if available)
TreeFam:
Gene Tree for RPSAP58 (if available)

Paralogs for RPSAP58 Gene

Paralogs for RPSAP58 Gene

Selected SIMAP similar genes for RPSAP58 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RPSAP58: view

Variants for RPSAP58 Gene

Sequence variations from dbSNP and Humsavar for RPSAP58 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1134225 -- 23,813,129(-) ttctc(C/T)caagt intron-variant
rs4283347 -- 23,811,350(+) TGTTA(C/T)ATAAC intron-variant
rs4287706 -- 23,800,203(+) tattt(A/T)atttt intron-variant
rs4293508 -- 23,800,873(+) cccca(A/G)agtgc intron-variant
rs4387719 -- 23,770,564(+) TGTGA(A/C)ATATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPSAP58 Gene

Variant ID Type Subtype PubMed ID
esv2751784 CNV Gain 17911159
nsv911466 CNV Gain 21882294
nsv524183 CNV Gain 19592680
esv2718381 CNV Deletion 23290073
dgv3821n71 CNV Gain 21882294
nsv911474 CNV Loss 21882294
esv2670676 CNV Deletion 23128226
esv4296 CNV Complex 18987735
esv2619335 CNV Deletion 19546169
esv2268001 CNV Deletion 18987734
esv9336 CNV Loss 19470904
esv2718383 CNV Deletion 23290073
nsv138127 CNV Loss 16902084
dgv556e201 CNV Deletion 23290073
esv2677185 CNV Deletion 23128226
esv2718386 CNV Deletion 23290073
nsv138104 CNV Loss 16902084
nsv2448 CNV Insertion 18451855

Relevant External Links for RPSAP58 Gene

HapMap Linkage Disequilibrium report
RPSAP58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPSAP58 Gene

Disorders for RPSAP58 Gene

No disorders were found for RPSAP58 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RPSAP58 Gene

Publications for RPSAP58 Gene

  1. Comparative analysis of processed ribosomal protein pseudogenes in four mammalian genomes. (PMID: 19123937) Balasubramanian S. … Gerstein M. (Genome Biol. 2009) 2 3
  2. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3

Products for RPSAP58 Gene

Sources for RPSAP58 Gene

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